-- dump date 20140618_203326 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443218000001 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 443218000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218000003 Magnesium ion binding site [ion binding]; other site 443218000004 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 443218000005 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218000006 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000007 LGFP repeat; Region: LGFP; pfam08310 443218000008 LGFP repeat; Region: LGFP; pfam08310 443218000009 LGFP repeat; Region: LGFP; pfam08310 443218000010 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443218000011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443218000012 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218000013 catalytic residues [active] 443218000014 catalytic nucleophile [active] 443218000015 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218000016 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218000017 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218000018 Synaptic Site I dimer interface [polypeptide binding]; other site 443218000019 DNA binding site [nucleotide binding] 443218000020 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218000021 DNA-binding interface [nucleotide binding]; DNA binding site 443218000022 TrwC relaxase; Region: TrwC; pfam08751 443218000023 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218000024 AAA domain; Region: AAA_30; pfam13604 443218000025 Family description; Region: UvrD_C_2; pfam13538 443218000026 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443218000027 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218000028 Helix-turn-helix domain; Region: HTH_38; pfam13936 443218000029 Integrase core domain; Region: rve; pfam00665 443218000030 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218000031 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 443218000032 Cysteine-rich domain; Region: CCG; pfam02754 443218000033 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000034 LGFP repeat; Region: LGFP; pfam08310 443218000035 LGFP repeat; Region: LGFP; pfam08310 443218000036 LGFP repeat; Region: LGFP; pfam08310 443218000037 LGFP repeat; Region: LGFP; pfam08310 443218000038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000040 active site 443218000041 phosphorylation site [posttranslational modification] 443218000042 intermolecular recognition site; other site 443218000043 dimerization interface [polypeptide binding]; other site 443218000044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000045 DNA binding residues [nucleotide binding] 443218000046 dimerization interface [polypeptide binding]; other site 443218000047 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 443218000048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218000049 Histidine kinase; Region: HisKA_3; pfam07730 443218000050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218000051 ATP binding site [chemical binding]; other site 443218000052 Mg2+ binding site [ion binding]; other site 443218000053 G-X-G motif; other site 443218000054 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000055 active site 443218000056 ATP binding site [chemical binding]; other site 443218000057 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 443218000058 substrate binding site [chemical binding]; other site 443218000059 activation loop (A-loop); other site 443218000060 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 443218000061 active site 443218000062 zinc binding site [ion binding]; other site 443218000063 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 443218000064 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443218000065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218000066 AAA domain; Region: AAA_31; pfam13614 443218000067 P-loop; other site 443218000068 Magnesium ion binding site [ion binding]; other site 443218000069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218000070 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443218000071 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 443218000072 DNA binding site [nucleotide binding] 443218000073 dimer interface [polypeptide binding]; other site 443218000074 active site 443218000075 Int/Topo IB signature motif; other site 443218000076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218000077 AAA domain; Region: AAA_21; pfam13304 443218000078 Walker A/P-loop; other site 443218000079 ATP binding site [chemical binding]; other site 443218000080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218000081 Walker B; other site 443218000082 D-loop; other site 443218000083 H-loop/switch region; other site 443218000084 Helix-turn-helix domain; Region: HTH_17; cl17695 443218000085 RES domain; Region: RES; pfam08808 443218000086 Helix-turn-helix domain; Region: HTH_17; cl17695 443218000087 RES domain; Region: RES; pfam08808 443218000088 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 443218000089 active site 443218000090 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218000091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000092 non-specific DNA binding site [nucleotide binding]; other site 443218000093 salt bridge; other site 443218000094 sequence-specific DNA binding site [nucleotide binding]; other site 443218000095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218000096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000097 non-specific DNA binding site [nucleotide binding]; other site 443218000098 salt bridge; other site 443218000099 sequence-specific DNA binding site [nucleotide binding]; other site 443218000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000101 non-specific DNA binding site [nucleotide binding]; other site 443218000102 salt bridge; other site 443218000103 sequence-specific DNA binding site [nucleotide binding]; other site 443218000104 Cutinase; Region: Cutinase; pfam01083 443218000105 AAA-like domain; Region: AAA_10; pfam12846 443218000106 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 443218000107 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443218000108 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218000109 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218000110 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218000111 catalytic residue [active] 443218000112 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 443218000113 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 443218000114 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218000115 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218000116 Restriction endonuclease; Region: Mrr_cat; pfam04471 443218000117 TrwC relaxase; Region: TrwC; pfam08751 443218000118 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218000119 AAA domain; Region: AAA_30; pfam13604 443218000120 Family description; Region: UvrD_C_2; pfam13538 443218000121 Protein of unknown function (DUF904); Region: DUF904; pfam06005 443218000122 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443218000123 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 443218000124 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218000125 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 443218000126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218000127 nucleotide binding region [chemical binding]; other site 443218000128 ATP-binding site [chemical binding]; other site 443218000129 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443218000130 MULE transposase domain; Region: MULE; pfam10551 443218000131 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443218000132 Abortive infection C-terminus; Region: Abi_C; pfam14355 443218000133 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443218000134 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218000135 catalytic nucleophile [active] 443218000136 Predicted helicase [General function prediction only]; Region: COG4889 443218000137 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 443218000138 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443218000139 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443218000140 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443218000141 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443218000142 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443218000143 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 443218000144 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 443218000145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218000146 ATP binding site [chemical binding]; other site 443218000147 putative Mg++ binding site [ion binding]; other site 443218000148 Protein of unknown function DUF45; Region: DUF45; pfam01863 443218000149 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218000150 cyclase homology domain; Region: CHD; cd07302 443218000151 nucleotidyl binding site; other site 443218000152 metal binding site [ion binding]; metal-binding site 443218000153 dimer interface [polypeptide binding]; other site 443218000154 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 443218000155 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443218000156 putative active site [active] 443218000157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 443218000158 Integrase core domain; Region: rve; pfam00665 443218000159 DNA-sulfur modification-associated; Region: DndB; cl17621 443218000160 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443218000161 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218000162 catalytic residues [active] 443218000163 catalytic nucleophile [active] 443218000164 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218000165 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218000166 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218000167 Synaptic Site I dimer interface [polypeptide binding]; other site 443218000168 DNA binding site [nucleotide binding] 443218000169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218000170 DNA-binding interface [nucleotide binding]; DNA binding site 443218000171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000172 non-specific DNA binding site [nucleotide binding]; other site 443218000173 salt bridge; other site 443218000174 sequence-specific DNA binding site [nucleotide binding]; other site 443218000175 Domain of unknown function (DUF955); Region: DUF955; cl01076 443218000176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218000177 AAA domain; Region: AAA_21; pfam13304 443218000178 Walker A/P-loop; other site 443218000179 ATP binding site [chemical binding]; other site 443218000180 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 443218000181 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 443218000182 putative active site [active] 443218000183 putative metal-binding site [ion binding]; other site 443218000184 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443218000185 Part of AAA domain; Region: AAA_19; pfam13245 443218000186 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443218000187 Family description; Region: UvrD_C_2; pfam13538 443218000188 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 443218000189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000190 Walker A motif; other site 443218000191 ATP binding site [chemical binding]; other site 443218000192 Walker B motif; other site 443218000193 arginine finger; other site 443218000194 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443218000195 DnaA box-binding interface [nucleotide binding]; other site 443218000196 DNA polymerase III subunit beta; Validated; Region: PRK07761 443218000197 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443218000198 putative DNA binding surface [nucleotide binding]; other site 443218000199 dimer interface [polypeptide binding]; other site 443218000200 beta-clamp/clamp loader binding surface; other site 443218000201 beta-clamp/translesion DNA polymerase binding surface; other site 443218000202 recombination protein F; Reviewed; Region: recF; PRK00064 443218000203 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 443218000204 Walker A/P-loop; other site 443218000205 ATP binding site [chemical binding]; other site 443218000206 Q-loop/lid; other site 443218000207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218000208 ABC transporter signature motif; other site 443218000209 Walker B; other site 443218000210 D-loop; other site 443218000211 H-loop/switch region; other site 443218000212 Protein of unknown function (DUF721); Region: DUF721; cl02324 443218000213 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443218000214 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218000215 ATP binding site [chemical binding]; other site 443218000216 Mg2+ binding site [ion binding]; other site 443218000217 G-X-G motif; other site 443218000218 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443218000219 anchoring element; other site 443218000220 dimer interface [polypeptide binding]; other site 443218000221 ATP binding site [chemical binding]; other site 443218000222 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443218000223 active site 443218000224 putative metal-binding site [ion binding]; other site 443218000225 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443218000226 DNA gyrase subunit A; Validated; Region: PRK05560 443218000227 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443218000228 CAP-like domain; other site 443218000229 active site 443218000230 primary dimer interface [polypeptide binding]; other site 443218000231 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000234 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000235 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000237 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443218000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218000239 putative substrate translocation pore; other site 443218000240 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443218000241 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443218000242 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218000243 NAD(P) binding site [chemical binding]; other site 443218000244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218000245 active site 443218000246 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 443218000247 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218000248 ATP binding site [chemical binding]; other site 443218000249 Mg++ binding site [ion binding]; other site 443218000250 motif III; other site 443218000251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218000252 nucleotide binding region [chemical binding]; other site 443218000253 ATP-binding site [chemical binding]; other site 443218000254 Helix-turn-helix domain; Region: HTH_17; pfam12728 443218000255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218000256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218000258 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218000259 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218000260 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218000261 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218000262 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218000263 hydrophobic ligand binding site; other site 443218000264 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 443218000265 active site 443218000266 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 443218000267 putative septation inhibitor protein; Reviewed; Region: PRK00159 443218000268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443218000269 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218000270 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443218000271 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443218000272 glutamine binding [chemical binding]; other site 443218000273 catalytic triad [active] 443218000274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000275 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218000276 active site 443218000277 ATP binding site [chemical binding]; other site 443218000278 substrate binding site [chemical binding]; other site 443218000279 activation loop (A-loop); other site 443218000280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000282 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000283 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000284 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000285 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218000286 active site 443218000287 ATP binding site [chemical binding]; other site 443218000288 substrate binding site [chemical binding]; other site 443218000289 activation loop (A-loop); other site 443218000290 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443218000291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218000292 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443218000293 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443218000294 active site 443218000295 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443218000296 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218000297 phosphopeptide binding site; other site 443218000298 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443218000299 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443218000300 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218000301 phosphopeptide binding site; other site 443218000302 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443218000303 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443218000304 active site 443218000305 dimer interface [polypeptide binding]; other site 443218000306 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443218000307 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218000308 active site 443218000309 FMN binding site [chemical binding]; other site 443218000310 substrate binding site [chemical binding]; other site 443218000311 3Fe-4S cluster binding site [ion binding]; other site 443218000312 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443218000313 domain interface; other site 443218000314 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443218000315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218000316 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 443218000317 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 443218000318 putative active site [active] 443218000319 putative substrate binding site [chemical binding]; other site 443218000320 putative FMN binding site [chemical binding]; other site 443218000321 putative catalytic residues [active] 443218000322 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218000323 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000324 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443218000325 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 443218000326 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443218000327 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443218000328 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218000329 NAD(P) binding site [chemical binding]; other site 443218000330 catalytic residues [active] 443218000331 CsbD-like; Region: CsbD; cl17424 443218000332 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218000333 hydrophobic ligand binding site; other site 443218000334 Copper resistance protein D; Region: CopD; pfam05425 443218000335 CopC domain; Region: CopC; pfam04234 443218000336 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443218000337 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 443218000338 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 443218000339 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443218000340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000341 NAD(P) binding site [chemical binding]; other site 443218000342 active site 443218000343 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443218000344 MgtE intracellular N domain; Region: MgtE_N; pfam03448 443218000345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443218000346 Divalent cation transporter; Region: MgtE; pfam01769 443218000347 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443218000348 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443218000349 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443218000350 methionine sulfoxide reductase A; Provisional; Region: PRK00058 443218000351 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218000352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218000353 Walker A/P-loop; other site 443218000354 ATP binding site [chemical binding]; other site 443218000355 Q-loop/lid; other site 443218000356 ABC transporter signature motif; other site 443218000357 Walker B; other site 443218000358 D-loop; other site 443218000359 H-loop/switch region; other site 443218000360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218000361 Histidine kinase; Region: HisKA_3; pfam07730 443218000362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000364 active site 443218000365 phosphorylation site [posttranslational modification] 443218000366 intermolecular recognition site; other site 443218000367 dimerization interface [polypeptide binding]; other site 443218000368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000369 DNA binding residues [nucleotide binding] 443218000370 dimerization interface [polypeptide binding]; other site 443218000371 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 443218000372 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 443218000373 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443218000374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218000375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218000376 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218000377 Walker A/P-loop; other site 443218000378 ATP binding site [chemical binding]; other site 443218000379 Q-loop/lid; other site 443218000380 ABC transporter signature motif; other site 443218000381 Walker B; other site 443218000382 D-loop; other site 443218000383 H-loop/switch region; other site 443218000384 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 443218000385 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443218000386 oligomer interface [polypeptide binding]; other site 443218000387 tandem repeat interface [polypeptide binding]; other site 443218000388 active site residues [active] 443218000389 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218000390 active site residue [active] 443218000391 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 443218000392 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218000393 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443218000394 active site 443218000395 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443218000396 Ferritin-like domain; Region: Ferritin; pfam00210 443218000397 ferroxidase diiron center [ion binding]; other site 443218000398 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 443218000399 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 443218000400 dimerization interface [polypeptide binding]; other site 443218000401 substrate binding pocket [chemical binding]; other site 443218000402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218000403 CAAX protease self-immunity; Region: Abi; pfam02517 443218000404 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 443218000405 prephenate dehydratase; Provisional; Region: PRK11898 443218000406 Prephenate dehydratase; Region: PDT; pfam00800 443218000407 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443218000408 putative L-Phe binding site [chemical binding]; other site 443218000409 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218000410 catalytic core [active] 443218000411 EspG family; Region: ESX-1_EspG; pfam14011 443218000412 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443218000413 PPE family; Region: PPE; pfam00823 443218000414 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 443218000415 Septum formation; Region: Septum_form; pfam13845 443218000416 Septum formation; Region: Septum_form; pfam13845 443218000417 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443218000418 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443218000419 seryl-tRNA synthetase; Provisional; Region: PRK05431 443218000420 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443218000421 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443218000422 dimer interface [polypeptide binding]; other site 443218000423 active site 443218000424 motif 1; other site 443218000425 motif 2; other site 443218000426 motif 3; other site 443218000427 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218000428 CoenzymeA binding site [chemical binding]; other site 443218000429 subunit interaction site [polypeptide binding]; other site 443218000430 PHB binding site; other site 443218000431 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218000432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218000433 putative acyl-acceptor binding pocket; other site 443218000434 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218000435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218000436 putative acyl-acceptor binding pocket; other site 443218000437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218000438 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443218000439 active site 443218000440 motif I; other site 443218000441 motif II; other site 443218000442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 443218000443 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000444 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443218000445 amidase catalytic site [active] 443218000446 Zn binding residues [ion binding]; other site 443218000447 substrate binding site [chemical binding]; other site 443218000448 LGFP repeat; Region: LGFP; pfam08310 443218000449 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443218000450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218000451 UDP-galactopyranose mutase; Region: GLF; pfam03275 443218000452 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218000453 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218000454 active site 443218000455 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443218000456 active site 443218000457 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443218000458 Predicted esterase [General function prediction only]; Region: COG0627 443218000459 Putative esterase; Region: Esterase; pfam00756 443218000460 LGFP repeat; Region: LGFP; pfam08310 443218000461 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000462 LGFP repeat; Region: LGFP; pfam08310 443218000463 LGFP repeat; Region: LGFP; pfam08310 443218000464 Cutinase; Region: Cutinase; pfam01083 443218000465 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 443218000466 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443218000467 acyl-activating enzyme (AAE) consensus motif; other site 443218000468 active site 443218000469 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443218000470 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218000471 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443218000472 active site 443218000473 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443218000474 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443218000475 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443218000476 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218000477 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443218000478 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218000479 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443218000480 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443218000481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 443218000482 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218000483 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 443218000484 iron-sulfur cluster [ion binding]; other site 443218000485 [2Fe-2S] cluster binding site [ion binding]; other site 443218000486 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 443218000487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218000488 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443218000489 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218000490 short chain dehydrogenase; Provisional; Region: PRK07904 443218000491 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218000492 NAD(P) binding site [chemical binding]; other site 443218000493 active site 443218000494 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218000495 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000496 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443218000497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218000499 WHG domain; Region: WHG; pfam13305 443218000500 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 443218000501 putative hydrophobic ligand binding site [chemical binding]; other site 443218000502 Predicted membrane protein [Function unknown]; Region: COG2246 443218000503 GtrA-like protein; Region: GtrA; pfam04138 443218000504 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 443218000505 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 443218000506 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443218000507 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443218000508 substrate binding site; other site 443218000509 tetramer interface; other site 443218000510 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218000511 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218000512 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 443218000513 Histidine kinase; Region: HisKA_3; pfam07730 443218000514 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218000515 ATP binding site [chemical binding]; other site 443218000516 Mg2+ binding site [ion binding]; other site 443218000517 G-X-G motif; other site 443218000518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000520 active site 443218000521 phosphorylation site [posttranslational modification] 443218000522 intermolecular recognition site; other site 443218000523 dimerization interface [polypeptide binding]; other site 443218000524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000525 DNA binding residues [nucleotide binding] 443218000526 dimerization interface [polypeptide binding]; other site 443218000527 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443218000528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218000529 ABC-ATPase subunit interface; other site 443218000530 dimer interface [polypeptide binding]; other site 443218000531 putative PBP binding regions; other site 443218000532 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218000533 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218000534 Walker A/P-loop; other site 443218000535 ATP binding site [chemical binding]; other site 443218000536 Q-loop/lid; other site 443218000537 ABC transporter signature motif; other site 443218000538 Walker B; other site 443218000539 D-loop; other site 443218000540 H-loop/switch region; other site 443218000541 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218000542 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218000543 intersubunit interface [polypeptide binding]; other site 443218000544 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443218000545 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443218000546 NAD binding site [chemical binding]; other site 443218000547 substrate binding site [chemical binding]; other site 443218000548 homodimer interface [polypeptide binding]; other site 443218000549 active site 443218000550 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 443218000551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218000552 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 443218000553 Isochorismatase family; Region: Isochorismatase; pfam00857 443218000554 catalytic triad [active] 443218000555 conserved cis-peptide bond; other site 443218000556 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 443218000557 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 443218000558 acyl-activating enzyme (AAE) consensus motif; other site 443218000559 active site 443218000560 AMP binding site [chemical binding]; other site 443218000561 substrate binding site [chemical binding]; other site 443218000562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000563 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 443218000564 NAD(P) binding site [chemical binding]; other site 443218000565 active site 443218000566 isochorismate synthase DhbC; Validated; Region: PRK06923 443218000567 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443218000568 Condensation domain; Region: Condensation; pfam00668 443218000569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218000570 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218000571 acyl-activating enzyme (AAE) consensus motif; other site 443218000572 AMP binding site [chemical binding]; other site 443218000573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218000574 Condensation domain; Region: Condensation; pfam00668 443218000575 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218000576 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218000577 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218000578 acyl-activating enzyme (AAE) consensus motif; other site 443218000579 AMP binding site [chemical binding]; other site 443218000580 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218000581 Condensation domain; Region: Condensation; pfam00668 443218000582 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218000583 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218000584 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218000585 intersubunit interface [polypeptide binding]; other site 443218000586 Condensation domain; Region: Condensation; pfam00668 443218000587 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218000588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218000589 acyl-activating enzyme (AAE) consensus motif; other site 443218000590 AMP binding site [chemical binding]; other site 443218000591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218000592 Condensation domain; Region: Condensation; pfam00668 443218000593 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218000594 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 443218000595 enterobactin exporter EntS; Provisional; Region: PRK10489 443218000596 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218000597 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218000598 FAD binding pocket [chemical binding]; other site 443218000599 FAD binding motif [chemical binding]; other site 443218000600 phosphate binding motif [ion binding]; other site 443218000601 NAD binding pocket [chemical binding]; other site 443218000602 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 443218000603 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218000604 metal ion-dependent adhesion site (MIDAS); other site 443218000605 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 443218000606 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218000607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218000608 active site 443218000609 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443218000610 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443218000611 Walker A/P-loop; other site 443218000612 ATP binding site [chemical binding]; other site 443218000613 Q-loop/lid; other site 443218000614 ABC transporter signature motif; other site 443218000615 Walker B; other site 443218000616 D-loop; other site 443218000617 H-loop/switch region; other site 443218000618 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443218000619 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443218000620 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 443218000621 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443218000622 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443218000623 NAD(P) binding site [chemical binding]; other site 443218000624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218000625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218000626 putative DNA binding site [nucleotide binding]; other site 443218000627 putative Zn2+ binding site [ion binding]; other site 443218000628 short chain dehydrogenase; Provisional; Region: PRK06172 443218000629 classical (c) SDRs; Region: SDR_c; cd05233 443218000630 NAD(P) binding site [chemical binding]; other site 443218000631 active site 443218000632 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218000633 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218000634 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443218000635 SnoaL-like domain; Region: SnoaL_2; pfam12680 443218000636 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218000637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218000638 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218000639 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 443218000640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218000641 Predicted oxidoreductase [General function prediction only]; Region: COG3573 443218000642 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 443218000643 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218000644 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218000645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000647 NAD(P) binding site [chemical binding]; other site 443218000648 active site 443218000649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218000650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000651 classical (c) SDRs; Region: SDR_c; cd05233 443218000652 NAD(P) binding site [chemical binding]; other site 443218000653 active site 443218000654 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218000655 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443218000656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218000657 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 443218000658 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 443218000659 putative active site [active] 443218000660 Fe(II) binding site [ion binding]; other site 443218000661 putative dimer interface [polypeptide binding]; other site 443218000662 putative tetramer interface [polypeptide binding]; other site 443218000663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218000664 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218000665 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218000666 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218000667 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443218000668 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443218000669 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443218000670 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443218000671 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443218000672 active site 443218000673 catalytic residues [active] 443218000674 metal binding site [ion binding]; metal-binding site 443218000675 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443218000676 putative succinate dehydrogenase; Reviewed; Region: PRK12842 443218000677 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218000678 hydrophobic ligand binding site; other site 443218000679 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 443218000680 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218000681 active site 443218000682 metal binding site [ion binding]; metal-binding site 443218000683 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 443218000684 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 443218000685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218000686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218000687 homodimer interface [polypeptide binding]; other site 443218000688 catalytic residue [active] 443218000689 Serine hydrolase (FSH1); Region: FSH1; pfam03959 443218000690 haloalkane dehalogenase; Provisional; Region: PRK03204 443218000691 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218000692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218000693 dimerization interface [polypeptide binding]; other site 443218000694 putative DNA binding site [nucleotide binding]; other site 443218000695 putative Zn2+ binding site [ion binding]; other site 443218000696 hypothetical protein; Provisional; Region: PRK07758 443218000697 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 443218000698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218000699 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218000700 DNA binding residues [nucleotide binding] 443218000701 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218000702 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443218000703 catalytic triad [active] 443218000704 Thioesterase domain; Region: Thioesterase; pfam00975 443218000705 Predicted membrane protein [Function unknown]; Region: COG2323 443218000706 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 443218000707 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 443218000708 Amidase; Region: Amidase; cl11426 443218000709 prephenate dehydrogenase; Validated; Region: PRK06545 443218000710 prephenate dehydrogenase; Validated; Region: PRK08507 443218000711 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 443218000712 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443218000713 dimer interface [polypeptide binding]; other site 443218000714 catalytic motif [active] 443218000715 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443218000716 Excalibur calcium-binding domain; Region: Excalibur; smart00894 443218000717 Inner membrane protein CreD; Region: CreD; cl01844 443218000718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443218000720 phosphorylation site [posttranslational modification] 443218000721 intermolecular recognition site; other site 443218000722 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 443218000723 putative deacylase active site [active] 443218000724 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218000725 MMPL family; Region: MMPL; pfam03176 443218000726 MMPL family; Region: MMPL; pfam03176 443218000727 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443218000728 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 443218000729 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 443218000730 RDD family; Region: RDD; pfam06271 443218000731 Bacitracin resistance protein BacA; Region: BacA; pfam02673 443218000732 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 443218000733 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 443218000734 active site 443218000735 HIGH motif; other site 443218000736 nucleotide binding site [chemical binding]; other site 443218000737 active site 443218000738 KMSKS motif; other site 443218000739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218000740 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 443218000741 Sodium Bile acid symporter family; Region: SBF; cl17470 443218000742 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 443218000743 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 443218000744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218000745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218000746 homodimer interface [polypeptide binding]; other site 443218000747 catalytic residue [active] 443218000748 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218000750 S-adenosylmethionine binding site [chemical binding]; other site 443218000751 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 443218000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000753 Walker A motif; other site 443218000754 ATP binding site [chemical binding]; other site 443218000755 Walker B motif; other site 443218000756 arginine finger; other site 443218000757 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443218000758 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443218000759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218000760 S-adenosylmethionine binding site [chemical binding]; other site 443218000761 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218000762 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000763 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218000764 hydrophobic ligand binding site; other site 443218000765 hypothetical protein; Validated; Region: PRK00153 443218000766 recombination protein RecR; Reviewed; Region: recR; PRK00076 443218000767 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218000768 RecR protein; Region: RecR; pfam02132 443218000769 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443218000770 putative active site [active] 443218000771 putative metal-binding site [ion binding]; other site 443218000772 tetramer interface [polypeptide binding]; other site 443218000773 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443218000774 catalytic triad [active] 443218000775 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 443218000776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218000777 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443218000778 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 443218000779 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 443218000780 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 443218000781 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218000782 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218000783 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 443218000784 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 443218000785 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218000786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218000787 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218000788 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218000789 2-isopropylmalate synthase; Validated; Region: PRK03739 443218000790 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443218000791 active site 443218000792 catalytic residues [active] 443218000793 metal binding site [ion binding]; metal-binding site 443218000794 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443218000795 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443218000796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000797 aspartate kinase; Reviewed; Region: PRK06635 443218000798 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443218000799 putative nucleotide binding site [chemical binding]; other site 443218000800 putative catalytic residues [active] 443218000801 putative Mg ion binding site [ion binding]; other site 443218000802 putative aspartate binding site [chemical binding]; other site 443218000803 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443218000804 putative allosteric regulatory site; other site 443218000805 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443218000806 putative allosteric regulatory residue; other site 443218000807 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443218000808 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443218000809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218000810 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218000811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218000813 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218000814 active site 443218000815 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218000816 active site 443218000817 short chain dehydrogenase; Provisional; Region: PRK07825 443218000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000819 NAD(P) binding site [chemical binding]; other site 443218000820 active site 443218000821 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218000822 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218000823 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443218000824 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218000825 metal binding site 2 [ion binding]; metal-binding site 443218000826 putative DNA binding helix; other site 443218000827 metal binding site 1 [ion binding]; metal-binding site 443218000828 dimer interface [polypeptide binding]; other site 443218000829 structural Zn2+ binding site [ion binding]; other site 443218000830 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 443218000831 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 443218000832 tetramer interface [polypeptide binding]; other site 443218000833 heme binding pocket [chemical binding]; other site 443218000834 NADPH binding site [chemical binding]; other site 443218000835 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 443218000836 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 443218000837 dimerization interface [polypeptide binding]; other site 443218000838 DPS ferroxidase diiron center [ion binding]; other site 443218000839 ion pore; other site 443218000840 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443218000841 TrkA-N domain; Region: TrkA_N; pfam02254 443218000842 TrkA-C domain; Region: TrkA_C; pfam02080 443218000843 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 443218000844 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 443218000845 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443218000846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443218000847 putative active site [active] 443218000848 putative metal binding site [ion binding]; other site 443218000849 Transglycosylase; Region: Transgly; pfam00912 443218000850 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443218000851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443218000852 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000853 Transcription factor WhiB; Region: Whib; pfam02467 443218000854 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218000855 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443218000856 DTAP/Switch II; other site 443218000857 Switch I; other site 443218000858 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218000859 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443218000860 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218000861 DTAP/Switch II; other site 443218000862 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443218000863 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443218000864 homotrimer interaction site [polypeptide binding]; other site 443218000865 putative active site [active] 443218000866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218000867 catalytic core [active] 443218000868 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443218000869 putative active site [active] 443218000870 putative substrate binding site [chemical binding]; other site 443218000871 ATP binding site [chemical binding]; other site 443218000872 short chain dehydrogenase; Provisional; Region: PRK08251 443218000873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000874 NAD(P) binding site [chemical binding]; other site 443218000875 active site 443218000876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218000877 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218000878 active site 443218000879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218000880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443218000881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218000882 sequence-specific DNA binding site [nucleotide binding]; other site 443218000883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 443218000884 salt bridge; other site 443218000885 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443218000886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443218000887 ligand binding site [chemical binding]; other site 443218000888 flexible hinge region; other site 443218000889 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443218000890 putative switch regulator; other site 443218000891 non-specific DNA interactions [nucleotide binding]; other site 443218000892 DNA binding site [nucleotide binding] 443218000893 sequence specific DNA binding site [nucleotide binding]; other site 443218000894 putative cAMP binding site [chemical binding]; other site 443218000895 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 443218000896 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218000897 minor groove reading motif; other site 443218000898 helix-hairpin-helix signature motif; other site 443218000899 substrate binding pocket [chemical binding]; other site 443218000900 active site 443218000901 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 443218000902 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443218000903 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443218000904 catalytic residues [active] 443218000905 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443218000906 putative active site [active] 443218000907 putative CoA binding site [chemical binding]; other site 443218000908 nudix motif; other site 443218000909 metal binding site [ion binding]; metal-binding site 443218000910 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218000911 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443218000912 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218000913 PGAP1-like protein; Region: PGAP1; pfam07819 443218000914 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 443218000915 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218000916 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218000917 acetyl-CoA synthetase; Provisional; Region: PRK00174 443218000918 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 443218000919 active site 443218000920 CoA binding site [chemical binding]; other site 443218000921 acyl-activating enzyme (AAE) consensus motif; other site 443218000922 AMP binding site [chemical binding]; other site 443218000923 acetate binding site [chemical binding]; other site 443218000924 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218000925 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443218000926 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 443218000927 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443218000928 Type II/IV secretion system protein; Region: T2SE; pfam00437 443218000929 Walker A motif; other site 443218000930 ATP binding site [chemical binding]; other site 443218000931 Walker B motif; other site 443218000932 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443218000933 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 443218000934 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443218000935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218000936 ATP binding site [chemical binding]; other site 443218000937 putative Mg++ binding site [ion binding]; other site 443218000938 nucleotide binding region [chemical binding]; other site 443218000939 helicase superfamily c-terminal domain; Region: HELICc; smart00490 443218000940 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 443218000941 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218000942 active site 443218000943 catalytic triad [active] 443218000944 oxyanion hole [active] 443218000945 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 443218000946 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443218000947 active site 443218000948 interdomain interaction site; other site 443218000949 putative metal-binding site [ion binding]; other site 443218000950 nucleotide binding site [chemical binding]; other site 443218000951 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 443218000952 domain I; other site 443218000953 phosphate binding site [ion binding]; other site 443218000954 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443218000955 domain II; other site 443218000956 domain III; other site 443218000957 nucleotide binding site [chemical binding]; other site 443218000958 DNA binding groove [nucleotide binding] 443218000959 catalytic site [active] 443218000960 domain IV; other site 443218000961 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000962 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000963 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000964 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218000965 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218000966 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443218000967 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443218000968 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 443218000969 dimerization domain swap beta strand [polypeptide binding]; other site 443218000970 regulatory protein interface [polypeptide binding]; other site 443218000971 active site 443218000972 regulatory phosphorylation site [posttranslational modification]; other site 443218000973 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 443218000974 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 443218000975 active site 443218000976 P-loop; other site 443218000977 phosphorylation site [posttranslational modification] 443218000978 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 443218000979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443218000980 active site 443218000981 phosphorylation site [posttranslational modification] 443218000982 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443218000983 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443218000984 putative substrate binding site [chemical binding]; other site 443218000985 putative ATP binding site [chemical binding]; other site 443218000986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443218000987 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 443218000988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 443218000989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218000990 dimerization interface [polypeptide binding]; other site 443218000991 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218000992 cyclase homology domain; Region: CHD; cd07302 443218000993 nucleotidyl binding site; other site 443218000994 metal binding site [ion binding]; metal-binding site 443218000995 dimer interface [polypeptide binding]; other site 443218000996 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443218000997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000998 Walker A motif; other site 443218000999 ATP binding site [chemical binding]; other site 443218001000 Walker B motif; other site 443218001001 arginine finger; other site 443218001002 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 443218001003 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443218001004 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443218001005 heme binding site [chemical binding]; other site 443218001006 ferroxidase pore; other site 443218001007 ferroxidase diiron center [ion binding]; other site 443218001008 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 443218001009 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218001010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 443218001011 DNA-binding site [nucleotide binding]; DNA binding site 443218001012 FCD domain; Region: FCD; pfam07729 443218001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218001014 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 443218001015 Zn binding site [ion binding]; other site 443218001016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218001017 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218001018 acyl-activating enzyme (AAE) consensus motif; other site 443218001019 AMP binding site [chemical binding]; other site 443218001020 active site 443218001021 CoA binding site [chemical binding]; other site 443218001022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001023 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 443218001024 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218001025 putative trimer interface [polypeptide binding]; other site 443218001026 putative CoA binding site [chemical binding]; other site 443218001027 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218001028 putative trimer interface [polypeptide binding]; other site 443218001029 putative CoA binding site [chemical binding]; other site 443218001030 MarR family; Region: MarR_2; pfam12802 443218001031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218001032 MarR family; Region: MarR_2; cl17246 443218001033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218001034 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218001035 substrate binding pocket [chemical binding]; other site 443218001036 membrane-bound complex binding site; other site 443218001037 hinge residues; other site 443218001038 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443218001039 dimer interface [polypeptide binding]; other site 443218001040 substrate binding site [chemical binding]; other site 443218001041 metal binding sites [ion binding]; metal-binding site 443218001042 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 443218001043 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443218001044 putative hydrolase; Region: TIGR03624 443218001045 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443218001046 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443218001047 Ligand Binding Site [chemical binding]; other site 443218001048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218001049 active site 443218001050 FtsH Extracellular; Region: FtsH_ext; pfam06480 443218001051 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443218001052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001053 Walker A motif; other site 443218001054 ATP binding site [chemical binding]; other site 443218001055 Walker B motif; other site 443218001056 arginine finger; other site 443218001057 Peptidase family M41; Region: Peptidase_M41; pfam01434 443218001058 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 443218001059 homodecamer interface [polypeptide binding]; other site 443218001060 GTP cyclohydrolase I; Provisional; Region: PLN03044 443218001061 active site 443218001062 putative catalytic site residues [active] 443218001063 zinc binding site [ion binding]; other site 443218001064 GTP-CH-I/GFRP interaction surface; other site 443218001065 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218001066 dihydropteroate synthase; Region: DHPS; TIGR01496 443218001067 substrate binding pocket [chemical binding]; other site 443218001068 dimer interface [polypeptide binding]; other site 443218001069 inhibitor binding site; inhibition site 443218001070 Dihydroneopterin aldolase; Region: FolB; smart00905 443218001071 active site 443218001072 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443218001073 catalytic center binding site [active] 443218001074 ATP binding site [chemical binding]; other site 443218001075 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443218001076 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 443218001077 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443218001078 Rossmann-like domain; Region: Rossmann-like; pfam10727 443218001079 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443218001080 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443218001081 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443218001082 active site 443218001083 ATP-binding site [chemical binding]; other site 443218001084 pantoate-binding site; other site 443218001085 HXXH motif; other site 443218001086 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443218001087 tetramerization interface [polypeptide binding]; other site 443218001088 active site 443218001089 pantothenate kinase; Reviewed; Region: PRK13318 443218001090 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 443218001091 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218001092 active site residue [active] 443218001093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218001094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218001095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218001096 DNA binding residues [nucleotide binding] 443218001097 Asp23 family; Region: Asp23; pfam03780 443218001098 Asp23 family; Region: Asp23; cl00574 443218001099 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443218001100 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443218001101 dimer interface [polypeptide binding]; other site 443218001102 putative anticodon binding site; other site 443218001103 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443218001104 motif 1; other site 443218001105 dimer interface [polypeptide binding]; other site 443218001106 active site 443218001107 motif 2; other site 443218001108 motif 3; other site 443218001109 Lsr2; Region: Lsr2; pfam11774 443218001110 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443218001111 Clp amino terminal domain; Region: Clp_N; pfam02861 443218001112 Clp amino terminal domain; Region: Clp_N; pfam02861 443218001113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001114 Walker A motif; other site 443218001115 ATP binding site [chemical binding]; other site 443218001116 Walker B motif; other site 443218001117 arginine finger; other site 443218001118 UvrB/uvrC motif; Region: UVR; pfam02151 443218001119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001120 Walker A motif; other site 443218001121 ATP binding site [chemical binding]; other site 443218001122 Walker B motif; other site 443218001123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443218001124 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 443218001125 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 443218001126 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443218001127 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 443218001128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218001129 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218001130 catalytic site [active] 443218001131 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218001132 endonuclease III; Region: ENDO3c; smart00478 443218001133 minor groove reading motif; other site 443218001134 helix-hairpin-helix signature motif; other site 443218001135 substrate binding pocket [chemical binding]; other site 443218001136 active site 443218001137 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443218001138 active site clefts [active] 443218001139 zinc binding site [ion binding]; other site 443218001140 dimer interface [polypeptide binding]; other site 443218001141 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218001142 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 443218001143 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443218001144 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 443218001145 DNA repair protein RadA; Provisional; Region: PRK11823 443218001146 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443218001147 Walker A motif; other site 443218001148 ATP binding site [chemical binding]; other site 443218001149 Walker B motif; other site 443218001150 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443218001151 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443218001152 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443218001153 CDP-binding sites; other site 443218001154 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443218001155 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218001156 active site 443218001157 HIGH motif; other site 443218001158 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218001159 KMSKS motif; other site 443218001160 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443218001161 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218001162 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 443218001163 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443218001164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001165 active site 443218001166 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443218001167 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218001168 inhibitor-cofactor binding pocket; inhibition site 443218001169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218001170 catalytic residue [active] 443218001171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001172 catalytic core [active] 443218001173 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443218001174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443218001175 catalytic residues [active] 443218001176 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443218001177 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 443218001178 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443218001179 ResB-like family; Region: ResB; pfam05140 443218001180 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443218001181 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443218001182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218001183 P-loop; other site 443218001184 Magnesium ion binding site [ion binding]; other site 443218001185 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 443218001186 DNA binding residues [nucleotide binding] 443218001187 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443218001188 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443218001189 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443218001190 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218001191 catalytic residue [active] 443218001192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443218001193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218001194 Walker A/P-loop; other site 443218001195 ATP binding site [chemical binding]; other site 443218001196 Q-loop/lid; other site 443218001197 ABC transporter signature motif; other site 443218001198 Walker B; other site 443218001199 D-loop; other site 443218001200 H-loop/switch region; other site 443218001201 FtsX-like permease family; Region: FtsX; pfam02687 443218001202 Membrane protein of unknown function; Region: DUF360; cl00850 443218001203 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218001204 Helix-turn-helix domain; Region: HTH_38; pfam13936 443218001205 Integrase core domain; Region: rve; pfam00665 443218001206 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 443218001207 UbiA prenyltransferase family; Region: UbiA; pfam01040 443218001208 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 443218001209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218001210 acyl-activating enzyme (AAE) consensus motif; other site 443218001211 AMP binding site [chemical binding]; other site 443218001212 active site 443218001213 CoA binding site [chemical binding]; other site 443218001214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218001215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218001216 active site 443218001217 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443218001218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001219 substrate binding site [chemical binding]; other site 443218001220 oxyanion hole (OAH) forming residues; other site 443218001221 trimer interface [polypeptide binding]; other site 443218001222 Ferredoxin [Energy production and conversion]; Region: COG1146 443218001223 4Fe-4S binding domain; Region: Fer4; pfam00037 443218001224 ferredoxin-NADP+ reductase; Region: PLN02852 443218001225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218001226 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443218001227 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443218001228 active site 443218001229 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443218001230 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443218001231 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443218001232 dimer interface [polypeptide binding]; other site 443218001233 tetramer interface [polypeptide binding]; other site 443218001234 PYR/PP interface [polypeptide binding]; other site 443218001235 TPP binding site [chemical binding]; other site 443218001236 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443218001237 TPP-binding site; other site 443218001238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218001239 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443218001240 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443218001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218001242 S-adenosylmethionine binding site [chemical binding]; other site 443218001243 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218001244 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218001245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218001247 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443218001248 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443218001249 substrate binding pocket [chemical binding]; other site 443218001250 chain length determination region; other site 443218001251 substrate-Mg2+ binding site; other site 443218001252 catalytic residues [active] 443218001253 aspartate-rich region 1; other site 443218001254 active site lid residues [active] 443218001255 aspartate-rich region 2; other site 443218001256 heat shock protein HtpX; Provisional; Region: PRK03072 443218001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443218001258 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443218001259 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218001260 active site 443218001261 catalytic site [active] 443218001262 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218001263 active site 2 [active] 443218001264 active site 1 [active] 443218001265 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443218001266 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443218001267 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443218001268 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443218001269 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443218001270 putative homodimer interface [polypeptide binding]; other site 443218001271 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443218001272 heterodimer interface [polypeptide binding]; other site 443218001273 homodimer interface [polypeptide binding]; other site 443218001274 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443218001275 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443218001276 23S rRNA interface [nucleotide binding]; other site 443218001277 L7/L12 interface [polypeptide binding]; other site 443218001278 putative thiostrepton binding site; other site 443218001279 L25 interface [polypeptide binding]; other site 443218001280 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443218001281 mRNA/rRNA interface [nucleotide binding]; other site 443218001282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 443218001283 Integrase core domain; Region: rve; pfam00665 443218001284 Integrase core domain; Region: rve_3; pfam13683 443218001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001286 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443218001287 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443218001288 23S rRNA interface [nucleotide binding]; other site 443218001289 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443218001290 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443218001291 core dimer interface [polypeptide binding]; other site 443218001292 peripheral dimer interface [polypeptide binding]; other site 443218001293 L10 interface [polypeptide binding]; other site 443218001294 L11 interface [polypeptide binding]; other site 443218001295 putative EF-Tu interaction site [polypeptide binding]; other site 443218001296 putative EF-G interaction site [polypeptide binding]; other site 443218001297 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218001298 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443218001299 Walker A/P-loop; other site 443218001300 ATP binding site [chemical binding]; other site 443218001301 Q-loop/lid; other site 443218001302 ABC transporter signature motif; other site 443218001303 Walker B; other site 443218001304 D-loop; other site 443218001305 H-loop/switch region; other site 443218001306 Permease; Region: Permease; pfam02405 443218001307 Permease; Region: Permease; pfam02405 443218001308 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218001309 mce related protein; Region: MCE; pfam02470 443218001310 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001311 mce related protein; Region: MCE; pfam02470 443218001312 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001313 mce related protein; Region: MCE; pfam02470 443218001314 mce related protein; Region: MCE; pfam02470 443218001315 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001316 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001317 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001318 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218001319 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218001320 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443218001321 Walker A/P-loop; other site 443218001322 ATP binding site [chemical binding]; other site 443218001323 Q-loop/lid; other site 443218001324 ABC transporter signature motif; other site 443218001325 Walker B; other site 443218001326 D-loop; other site 443218001327 H-loop/switch region; other site 443218001328 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218001329 Permease; Region: Permease; pfam02405 443218001330 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218001331 Permease; Region: Permease; pfam02405 443218001332 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001333 mce related protein; Region: MCE; pfam02470 443218001334 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001335 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218001336 mce related protein; Region: MCE; pfam02470 443218001337 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001338 mce related protein; Region: MCE; pfam02470 443218001339 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001340 mce related protein; Region: MCE; pfam02470 443218001341 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001342 mce related protein; Region: MCE; pfam02470 443218001343 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001344 mce related protein; Region: MCE; pfam02470 443218001345 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001346 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443218001347 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443218001348 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443218001349 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443218001350 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443218001351 RPB10 interaction site [polypeptide binding]; other site 443218001352 RPB1 interaction site [polypeptide binding]; other site 443218001353 RPB11 interaction site [polypeptide binding]; other site 443218001354 RPB3 interaction site [polypeptide binding]; other site 443218001355 RPB12 interaction site [polypeptide binding]; other site 443218001356 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443218001357 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443218001358 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443218001359 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443218001360 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443218001361 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443218001362 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443218001363 G-loop; other site 443218001364 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443218001365 DNA binding site [nucleotide binding] 443218001366 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443218001367 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 443218001368 putative active site [active] 443218001369 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443218001370 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218001371 active site 443218001372 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 443218001373 active site 2 [active] 443218001374 active site 1 [active] 443218001375 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001376 catalytic core [active] 443218001377 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218001378 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443218001379 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218001380 hydrophobic ligand binding site; other site 443218001381 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 443218001382 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218001383 active site 443218001384 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218001385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001386 substrate binding site [chemical binding]; other site 443218001387 oxyanion hole (OAH) forming residues; other site 443218001388 trimer interface [polypeptide binding]; other site 443218001389 TIGR03084 family protein; Region: TIGR03084 443218001390 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443218001391 Wyosine base formation; Region: Wyosine_form; pfam08608 443218001392 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 443218001393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218001394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001395 active site 443218001396 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 443218001397 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218001398 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218001399 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218001400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218001401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218001402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443218001403 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218001404 carboxyltransferase (CT) interaction site; other site 443218001405 biotinylation site [posttranslational modification]; other site 443218001406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218001407 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218001408 active site 443218001409 enoyl-CoA hydratase; Provisional; Region: PRK07827 443218001410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001411 substrate binding site [chemical binding]; other site 443218001412 oxyanion hole (OAH) forming residues; other site 443218001413 trimer interface [polypeptide binding]; other site 443218001414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218001416 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218001417 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218001418 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443218001419 S17 interaction site [polypeptide binding]; other site 443218001420 S8 interaction site; other site 443218001421 16S rRNA interaction site [nucleotide binding]; other site 443218001422 streptomycin interaction site [chemical binding]; other site 443218001423 23S rRNA interaction site [nucleotide binding]; other site 443218001424 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443218001425 30S ribosomal protein S7; Validated; Region: PRK05302 443218001426 elongation factor G; Reviewed; Region: PRK00007 443218001427 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443218001428 G1 box; other site 443218001429 putative GEF interaction site [polypeptide binding]; other site 443218001430 GTP/Mg2+ binding site [chemical binding]; other site 443218001431 Switch I region; other site 443218001432 G2 box; other site 443218001433 G3 box; other site 443218001434 Switch II region; other site 443218001435 G4 box; other site 443218001436 G5 box; other site 443218001437 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443218001438 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443218001439 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443218001440 elongation factor Tu; Reviewed; Region: PRK00049 443218001441 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443218001442 G1 box; other site 443218001443 GEF interaction site [polypeptide binding]; other site 443218001444 GTP/Mg2+ binding site [chemical binding]; other site 443218001445 Switch I region; other site 443218001446 G2 box; other site 443218001447 G3 box; other site 443218001448 Switch II region; other site 443218001449 G4 box; other site 443218001450 G5 box; other site 443218001451 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443218001452 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443218001453 Antibiotic Binding Site [chemical binding]; other site 443218001454 Condensation domain; Region: Condensation; pfam00668 443218001455 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001456 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218001457 acyl-activating enzyme (AAE) consensus motif; other site 443218001458 AMP binding site [chemical binding]; other site 443218001459 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001460 Condensation domain; Region: Condensation; pfam00668 443218001461 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218001462 Condensation domain; Region: Condensation; pfam00668 443218001463 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218001464 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001465 acyl-activating enzyme (AAE) consensus motif; other site 443218001466 AMP binding site [chemical binding]; other site 443218001467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001468 Condensation domain; Region: Condensation; pfam00668 443218001469 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218001470 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001471 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001472 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218001473 acyl-activating enzyme (AAE) consensus motif; other site 443218001474 AMP binding site [chemical binding]; other site 443218001475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001476 Condensation domain; Region: Condensation; pfam00668 443218001477 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218001478 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001479 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001480 acyl-activating enzyme (AAE) consensus motif; other site 443218001481 AMP binding site [chemical binding]; other site 443218001482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001483 Condensation domain; Region: Condensation; pfam00668 443218001484 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218001485 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001486 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001487 acyl-activating enzyme (AAE) consensus motif; other site 443218001488 AMP binding site [chemical binding]; other site 443218001489 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001490 Condensation domain; Region: Condensation; pfam00668 443218001491 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218001492 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218001494 acyl-activating enzyme (AAE) consensus motif; other site 443218001495 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001496 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218001497 acyl-activating enzyme (AAE) consensus motif; other site 443218001498 AMP binding site [chemical binding]; other site 443218001499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001500 peptide synthase; Provisional; Region: PRK12467 443218001501 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001503 acyl-activating enzyme (AAE) consensus motif; other site 443218001504 AMP binding site [chemical binding]; other site 443218001505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001508 acyl-activating enzyme (AAE) consensus motif; other site 443218001509 AMP binding site [chemical binding]; other site 443218001510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001511 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218001512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001513 acyl-activating enzyme (AAE) consensus motif; other site 443218001514 AMP binding site [chemical binding]; other site 443218001515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001516 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218001517 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001518 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218001519 acyl-activating enzyme (AAE) consensus motif; other site 443218001520 AMP binding site [chemical binding]; other site 443218001521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218001522 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001523 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001524 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218001525 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001526 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218001527 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218001528 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218001529 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218001530 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218001531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218001532 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218001533 Walker A/P-loop; other site 443218001534 ATP binding site [chemical binding]; other site 443218001535 Q-loop/lid; other site 443218001536 ABC transporter signature motif; other site 443218001537 Walker B; other site 443218001538 D-loop; other site 443218001539 H-loop/switch region; other site 443218001540 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 443218001541 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443218001542 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218001543 CoenzymeA binding site [chemical binding]; other site 443218001544 subunit interaction site [polypeptide binding]; other site 443218001545 PHB binding site; other site 443218001546 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443218001547 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443218001548 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443218001549 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443218001550 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443218001551 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443218001552 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443218001553 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 443218001554 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443218001555 putative translocon binding site; other site 443218001556 protein-rRNA interface [nucleotide binding]; other site 443218001557 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443218001558 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443218001559 G-X-X-G motif; other site 443218001560 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443218001561 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443218001562 23S rRNA interface [nucleotide binding]; other site 443218001563 5S rRNA interface [nucleotide binding]; other site 443218001564 putative antibiotic binding site [chemical binding]; other site 443218001565 L25 interface [polypeptide binding]; other site 443218001566 L27 interface [polypeptide binding]; other site 443218001567 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443218001568 23S rRNA interface [nucleotide binding]; other site 443218001569 putative translocon interaction site; other site 443218001570 signal recognition particle (SRP54) interaction site; other site 443218001571 L23 interface [polypeptide binding]; other site 443218001572 trigger factor interaction site; other site 443218001573 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443218001574 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443218001575 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443218001576 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443218001577 RNA binding site [nucleotide binding]; other site 443218001578 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443218001579 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443218001580 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443218001581 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 443218001582 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443218001583 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443218001584 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443218001585 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443218001586 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443218001587 5S rRNA interface [nucleotide binding]; other site 443218001588 L27 interface [polypeptide binding]; other site 443218001589 23S rRNA interface [nucleotide binding]; other site 443218001590 L5 interface [polypeptide binding]; other site 443218001591 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443218001592 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443218001593 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443218001594 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443218001595 23S rRNA binding site [nucleotide binding]; other site 443218001596 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443218001597 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443218001598 SecY translocase; Region: SecY; pfam00344 443218001599 adenylate kinase; Reviewed; Region: adk; PRK00279 443218001600 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443218001601 AMP-binding site [chemical binding]; other site 443218001602 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443218001603 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218001604 active site 443218001605 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443218001606 rRNA binding site [nucleotide binding]; other site 443218001607 predicted 30S ribosome binding site; other site 443218001608 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 443218001609 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443218001610 30S ribosomal protein S11; Validated; Region: PRK05309 443218001611 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443218001612 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443218001613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218001614 RNA binding surface [nucleotide binding]; other site 443218001615 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443218001616 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443218001617 alphaNTD - beta interaction site [polypeptide binding]; other site 443218001618 alphaNTD homodimer interface [polypeptide binding]; other site 443218001619 alphaNTD - beta' interaction site [polypeptide binding]; other site 443218001620 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443218001621 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443218001622 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443218001623 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 443218001624 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443218001625 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 443218001626 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443218001627 Predicted membrane protein [Function unknown]; Region: COG4129 443218001628 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443218001629 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 443218001630 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443218001631 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443218001632 GDP-binding site [chemical binding]; other site 443218001633 ACT binding site; other site 443218001634 IMP binding site; other site 443218001635 ribonuclease Z; Reviewed; Region: PRK00055 443218001636 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218001637 Probable transposase; Region: OrfB_IS605; pfam01385 443218001638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443218001639 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218001640 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218001641 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443218001642 catalytic residues [active] 443218001643 catalytic nucleophile [active] 443218001644 Transport protein; Region: actII; TIGR00833 443218001645 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443218001646 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443218001647 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443218001648 4Fe-4S binding domain; Region: Fer4; pfam00037 443218001649 ferredoxin-NADP+ reductase; Region: PLN02852 443218001650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218001651 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218001652 catalytic residues [active] 443218001653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218001654 Domain of unknown function (DUF368); Region: DUF368; pfam04018 443218001655 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 443218001656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001657 ATP-grasp domain; Region: ATP-grasp; pfam02222 443218001658 Protein of unknown function (DUF456); Region: DUF456; pfam04306 443218001659 ferredoxin-NADP+ reductase; Region: PLN02852 443218001660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218001661 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 443218001662 active site residue [active] 443218001663 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 443218001664 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218001665 homodimer interface [polypeptide binding]; other site 443218001666 substrate-cofactor binding pocket; other site 443218001667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218001668 catalytic residue [active] 443218001669 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 443218001670 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218001671 phosphate acetyltransferase; Reviewed; Region: PRK05632 443218001672 DRTGG domain; Region: DRTGG; pfam07085 443218001673 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443218001674 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443218001675 propionate/acetate kinase; Provisional; Region: PRK12379 443218001676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218001677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218001678 active site 443218001679 ATP binding site [chemical binding]; other site 443218001680 substrate binding site [chemical binding]; other site 443218001681 activation loop (A-loop); other site 443218001682 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443218001683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218001684 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218001685 substrate binding pocket [chemical binding]; other site 443218001686 membrane-bound complex binding site; other site 443218001687 hinge residues; other site 443218001688 NUDIX domain; Region: NUDIX; pfam00293 443218001689 nudix motif; other site 443218001690 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443218001691 thiamine phosphate binding site [chemical binding]; other site 443218001692 active site 443218001693 pyrophosphate binding site [ion binding]; other site 443218001694 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443218001695 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443218001696 thiS-thiF/thiG interaction site; other site 443218001697 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443218001698 ThiS interaction site; other site 443218001699 putative active site [active] 443218001700 tetramer interface [polypeptide binding]; other site 443218001701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218001702 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 443218001703 Walker A/P-loop; other site 443218001704 ATP binding site [chemical binding]; other site 443218001705 Q-loop/lid; other site 443218001706 ABC transporter signature motif; other site 443218001707 Walker B; other site 443218001708 D-loop; other site 443218001709 H-loop/switch region; other site 443218001710 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443218001711 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443218001712 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 443218001713 PA/protease or protease-like domain interface [polypeptide binding]; other site 443218001714 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 443218001715 Peptidase family M28; Region: Peptidase_M28; pfam04389 443218001716 active site 443218001717 metal binding site [ion binding]; metal-binding site 443218001718 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218001719 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218001720 intersubunit interface [polypeptide binding]; other site 443218001721 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218001722 cyclase homology domain; Region: CHD; cd07302 443218001723 nucleotidyl binding site; other site 443218001724 metal binding site [ion binding]; metal-binding site 443218001725 dimer interface [polypeptide binding]; other site 443218001726 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443218001727 dimer interface [polypeptide binding]; other site 443218001728 substrate binding site [chemical binding]; other site 443218001729 ATP binding site [chemical binding]; other site 443218001730 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 443218001731 ThiC-associated domain; Region: ThiC-associated; pfam13667 443218001732 ThiC family; Region: ThiC; pfam01964 443218001733 Predicted acetyltransferase [General function prediction only]; Region: COG2388 443218001734 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443218001735 putative catalytic site [active] 443218001736 putative phosphate binding site [ion binding]; other site 443218001737 active site 443218001738 metal binding site A [ion binding]; metal-binding site 443218001739 DNA binding site [nucleotide binding] 443218001740 putative AP binding site [nucleotide binding]; other site 443218001741 putative metal binding site B [ion binding]; other site 443218001742 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443218001743 active site 443218001744 catalytic residues [active] 443218001745 metal binding site [ion binding]; metal-binding site 443218001746 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 443218001747 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218001748 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443218001749 E-class dimer interface [polypeptide binding]; other site 443218001750 P-class dimer interface [polypeptide binding]; other site 443218001751 active site 443218001752 Cu2+ binding site [ion binding]; other site 443218001753 Zn2+ binding site [ion binding]; other site 443218001754 carboxylate-amine ligase; Provisional; Region: PRK13517 443218001755 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443218001756 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 443218001757 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 443218001758 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 443218001759 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 443218001760 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218001761 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 443218001762 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 443218001763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218001764 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 443218001765 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218001766 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 443218001767 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 443218001768 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 443218001769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001770 Walker A motif; other site 443218001771 ATP binding site [chemical binding]; other site 443218001772 Walker B motif; other site 443218001773 arginine finger; other site 443218001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001775 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443218001776 Walker A motif; other site 443218001777 ATP binding site [chemical binding]; other site 443218001778 Walker B motif; other site 443218001779 arginine finger; other site 443218001780 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218001781 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443218001782 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443218001783 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443218001784 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443218001785 dimer interface [polypeptide binding]; other site 443218001786 putative functional site; other site 443218001787 putative MPT binding site; other site 443218001788 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218001789 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218001790 Transcriptional regulator PadR-like family; Region: PadR; cl17335 443218001791 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218001792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001793 NAD(P) binding site [chemical binding]; other site 443218001794 active site 443218001795 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 443218001796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218001797 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443218001798 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 443218001799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218001800 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443218001801 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443218001802 active site 443218001803 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443218001804 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218001805 ring oligomerisation interface [polypeptide binding]; other site 443218001806 ATP/Mg binding site [chemical binding]; other site 443218001807 stacking interactions; other site 443218001808 hinge regions; other site 443218001809 PBP superfamily domain; Region: PBP_like_2; cl17296 443218001810 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443218001811 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443218001812 Gas vesicle protein; Region: Gas_vesicle; cl02954 443218001813 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 443218001814 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 443218001815 Gas vesicle protein; Region: Gas_vesicle; pfam00741 443218001816 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 443218001817 Gas vesicle protein; Region: Gas_vesicle; pfam00741 443218001818 Gas vesicle protein K; Region: GvpK; pfam05121 443218001819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218001820 PHB binding site; other site 443218001821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218001823 active site 443218001824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218001826 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 443218001827 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218001828 Amidase; Region: Amidase; cl11426 443218001829 Amidase; Region: Amidase; cl11426 443218001830 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 443218001831 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 443218001832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218001833 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218001834 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218001835 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443218001836 short chain dehydrogenase; Provisional; Region: PRK05872 443218001837 classical (c) SDRs; Region: SDR_c; cd05233 443218001838 NAD(P) binding site [chemical binding]; other site 443218001839 active site 443218001840 allophanate hydrolase; Region: allophanate_hyd; TIGR02713 443218001841 Amidase; Region: Amidase; cl11426 443218001842 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 443218001843 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 443218001844 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443218001845 Walker A/P-loop; other site 443218001846 ATP binding site [chemical binding]; other site 443218001847 Q-loop/lid; other site 443218001848 ABC transporter signature motif; other site 443218001849 Walker B; other site 443218001850 D-loop; other site 443218001851 H-loop/switch region; other site 443218001852 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 443218001853 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443218001854 Walker A/P-loop; other site 443218001855 ATP binding site [chemical binding]; other site 443218001856 Q-loop/lid; other site 443218001857 ABC transporter signature motif; other site 443218001858 Walker B; other site 443218001859 D-loop; other site 443218001860 H-loop/switch region; other site 443218001861 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443218001862 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218001863 TM-ABC transporter signature motif; other site 443218001864 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218001865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443218001866 TM-ABC transporter signature motif; other site 443218001867 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218001868 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 443218001869 putative ligand binding site [chemical binding]; other site 443218001870 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218001871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218001872 non-specific DNA binding site [nucleotide binding]; other site 443218001873 salt bridge; other site 443218001874 sequence-specific DNA binding site [nucleotide binding]; other site 443218001875 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443218001876 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443218001877 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443218001878 isocitrate lyase; Provisional; Region: PRK15063 443218001879 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443218001880 tetramer interface [polypeptide binding]; other site 443218001881 active site 443218001882 Mg2+/Mn2+ binding site [ion binding]; other site 443218001883 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443218001884 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443218001885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218001886 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443218001887 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443218001888 THF binding site; other site 443218001889 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443218001890 substrate binding site [chemical binding]; other site 443218001891 THF binding site; other site 443218001892 zinc-binding site [ion binding]; other site 443218001893 Predicted membrane protein [Function unknown]; Region: COG2733 443218001894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218001895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218001896 non-specific DNA binding site [nucleotide binding]; other site 443218001897 salt bridge; other site 443218001898 sequence-specific DNA binding site [nucleotide binding]; other site 443218001899 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 443218001900 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443218001901 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218001902 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218001903 DNA binding residues [nucleotide binding] 443218001904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218001905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218001906 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 443218001907 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443218001908 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443218001909 putative active site [active] 443218001910 putative substrate binding site [chemical binding]; other site 443218001911 putative cosubstrate binding site; other site 443218001912 catalytic site [active] 443218001913 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443218001914 intersubunit interface [polypeptide binding]; other site 443218001915 active site 443218001916 catalytic residue [active] 443218001917 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443218001918 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443218001919 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443218001920 FAD binding domain; Region: FAD_binding_4; pfam01565 443218001921 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443218001922 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218001923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001924 NAD(P) binding site [chemical binding]; other site 443218001925 active site 443218001926 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218001927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001928 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443218001929 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 443218001930 putative ADP-binding pocket [chemical binding]; other site 443218001931 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 443218001932 4-coumarate--CoA ligase; Region: PLN02246 443218001933 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 443218001934 acyl-activating enzyme (AAE) consensus motif; other site 443218001935 active site 443218001936 putative CoA binding site [chemical binding]; other site 443218001937 AMP binding site [chemical binding]; other site 443218001938 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001939 catalytic core [active] 443218001940 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443218001941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218001942 dimer interface [polypeptide binding]; other site 443218001943 phosphorylation site [posttranslational modification] 443218001944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218001945 ATP binding site [chemical binding]; other site 443218001946 Mg2+ binding site [ion binding]; other site 443218001947 G-X-G motif; other site 443218001948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218001949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218001950 active site 443218001951 phosphorylation site [posttranslational modification] 443218001952 intermolecular recognition site; other site 443218001953 dimerization interface [polypeptide binding]; other site 443218001954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218001955 DNA binding site [nucleotide binding] 443218001956 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443218001957 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443218001958 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218001959 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443218001960 catalytic site [active] 443218001961 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443218001962 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443218001963 DNA binding domain, excisionase family; Region: excise; TIGR01764 443218001964 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443218001965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001966 NAD(P) binding site [chemical binding]; other site 443218001967 active site 443218001968 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218001969 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218001970 putative acyl-acceptor binding pocket; other site 443218001971 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218001972 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443218001973 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 443218001974 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 443218001975 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443218001976 tRNA; other site 443218001977 putative tRNA binding site [nucleotide binding]; other site 443218001978 putative NADP binding site [chemical binding]; other site 443218001979 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443218001980 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 443218001981 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443218001982 domain interfaces; other site 443218001983 active site 443218001984 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 443218001985 active site 443218001986 homodimer interface [polypeptide binding]; other site 443218001987 SAM binding site [chemical binding]; other site 443218001988 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443218001989 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443218001990 active site 443218001991 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443218001992 dimer interface [polypeptide binding]; other site 443218001993 active site 443218001994 Schiff base residues; other site 443218001995 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 443218001996 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 443218001997 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 443218001998 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 443218001999 putative active site [active] 443218002000 dimer interface [polypeptide binding]; other site 443218002001 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443218002002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218002003 putative PBP binding regions; other site 443218002004 ABC-ATPase subunit interface; other site 443218002005 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218002006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002007 Walker A/P-loop; other site 443218002008 ATP binding site [chemical binding]; other site 443218002009 Q-loop/lid; other site 443218002010 ABC transporter signature motif; other site 443218002011 Walker B; other site 443218002012 D-loop; other site 443218002013 H-loop/switch region; other site 443218002014 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218002015 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218002016 intersubunit interface [polypeptide binding]; other site 443218002017 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218002018 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218002019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218002020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218002021 DNA binding site [nucleotide binding] 443218002022 domain linker motif; other site 443218002023 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 443218002024 putative dimerization interface [polypeptide binding]; other site 443218002025 putative ligand binding site [chemical binding]; other site 443218002026 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 443218002027 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 443218002028 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218002029 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218002030 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443218002031 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443218002032 active site 443218002033 homotetramer interface [polypeptide binding]; other site 443218002034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218002035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218002036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002037 Walker A/P-loop; other site 443218002038 ATP binding site [chemical binding]; other site 443218002039 Q-loop/lid; other site 443218002040 ABC transporter signature motif; other site 443218002041 Walker B; other site 443218002042 D-loop; other site 443218002043 H-loop/switch region; other site 443218002044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218002045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218002046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002047 Walker A/P-loop; other site 443218002048 ATP binding site [chemical binding]; other site 443218002049 Q-loop/lid; other site 443218002050 ABC transporter signature motif; other site 443218002051 Walker B; other site 443218002052 D-loop; other site 443218002053 H-loop/switch region; other site 443218002054 MbtH-like protein; Region: MbtH; pfam03621 443218002055 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 443218002056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443218002057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443218002058 TPR motif; other site 443218002059 binding surface 443218002060 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443218002061 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218002062 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443218002063 nucleotide binding site/active site [active] 443218002064 HIT family signature motif; other site 443218002065 catalytic residue [active] 443218002066 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443218002067 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443218002068 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443218002069 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443218002070 aspartate aminotransferase; Provisional; Region: PRK05764 443218002071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218002072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218002073 homodimer interface [polypeptide binding]; other site 443218002074 catalytic residue [active] 443218002075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443218002076 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443218002077 synthetase active site [active] 443218002078 NTP binding site [chemical binding]; other site 443218002079 metal binding site [ion binding]; metal-binding site 443218002080 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 443218002081 Lyase; Region: Lyase_1; pfam00206 443218002082 tetramer interface [polypeptide binding]; other site 443218002083 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443218002084 HIT family signature motif; other site 443218002085 catalytic residue [active] 443218002086 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443218002087 active site 443218002088 ATP binding site [chemical binding]; other site 443218002089 substrate binding site [chemical binding]; other site 443218002090 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443218002091 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218002092 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 443218002093 catalytic residues [active] 443218002094 dimer interface [polypeptide binding]; other site 443218002095 Predicted deacetylase [General function prediction only]; Region: COG3233 443218002096 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 443218002097 putative active site [active] 443218002098 putative Zn binding site [ion binding]; other site 443218002099 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443218002100 FAD binding domain; Region: FAD_binding_2; pfam00890 443218002101 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443218002102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218002103 Walker A/P-loop; other site 443218002104 ATP binding site [chemical binding]; other site 443218002105 Q-loop/lid; other site 443218002106 ABC transporter signature motif; other site 443218002107 Walker B; other site 443218002108 D-loop; other site 443218002109 H-loop/switch region; other site 443218002110 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443218002111 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443218002112 FtsX-like permease family; Region: FtsX; pfam02687 443218002113 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443218002114 FtsX-like permease family; Region: FtsX; pfam02687 443218002115 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443218002116 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 443218002117 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 443218002118 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 443218002119 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443218002120 putative active site [active] 443218002121 catalytic triad [active] 443218002122 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218002123 Predicted membrane protein [Function unknown]; Region: COG4763 443218002124 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218002125 Protein of unknown function DUF58; Region: DUF58; pfam01882 443218002126 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218002127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218002128 Walker A motif; other site 443218002129 ATP binding site [chemical binding]; other site 443218002130 Walker B motif; other site 443218002131 arginine finger; other site 443218002132 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443218002133 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443218002134 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443218002135 dimerization interface [polypeptide binding]; other site 443218002136 ATP binding site [chemical binding]; other site 443218002137 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443218002138 dimerization interface [polypeptide binding]; other site 443218002139 ATP binding site [chemical binding]; other site 443218002140 Predicted membrane protein [Function unknown]; Region: COG4425 443218002141 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218002142 CAAX protease self-immunity; Region: Abi; pfam02517 443218002143 amidophosphoribosyltransferase; Provisional; Region: PRK07847 443218002144 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443218002145 active site 443218002146 tetramer interface [polypeptide binding]; other site 443218002147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218002148 active site 443218002149 short chain dehydrogenase; Provisional; Region: PRK06197 443218002150 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218002151 putative NAD(P) binding site [chemical binding]; other site 443218002152 active site 443218002153 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 443218002154 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443218002155 dimerization interface [polypeptide binding]; other site 443218002156 putative ATP binding site [chemical binding]; other site 443218002157 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 443218002158 L-asparaginase II; Region: Asparaginase_II; pfam06089 443218002159 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443218002160 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443218002161 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002162 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443218002163 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 443218002164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218002165 catalytic residue [active] 443218002166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002168 Predicted flavoprotein [General function prediction only]; Region: COG0431 443218002169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218002171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218002172 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 443218002173 active site 443218002174 catalytic residues [active] 443218002175 metal binding site [ion binding]; metal-binding site 443218002176 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218002177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218002178 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 443218002179 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443218002180 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443218002181 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443218002182 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218002183 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 443218002184 Walker A/P-loop; other site 443218002185 ATP binding site [chemical binding]; other site 443218002186 ABC transporter; Region: ABC_tran; pfam00005 443218002187 Q-loop/lid; other site 443218002188 ABC transporter signature motif; other site 443218002189 Walker B; other site 443218002190 D-loop; other site 443218002191 H-loop/switch region; other site 443218002192 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443218002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002194 Walker A/P-loop; other site 443218002195 ATP binding site [chemical binding]; other site 443218002196 Q-loop/lid; other site 443218002197 ABC transporter signature motif; other site 443218002198 Walker B; other site 443218002199 D-loop; other site 443218002200 H-loop/switch region; other site 443218002201 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 443218002202 elongation factor G; Reviewed; Region: PRK12740 443218002203 G1 box; other site 443218002204 putative GEF interaction site [polypeptide binding]; other site 443218002205 GTP/Mg2+ binding site [chemical binding]; other site 443218002206 Switch I region; other site 443218002207 G2 box; other site 443218002208 G3 box; other site 443218002209 Switch II region; other site 443218002210 G4 box; other site 443218002211 G5 box; other site 443218002212 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443218002213 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443218002214 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443218002215 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218002216 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443218002217 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 443218002218 NAD(P) binding site [chemical binding]; other site 443218002219 catalytic residues [active] 443218002220 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218002221 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218002222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218002223 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218002224 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218002225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218002226 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218002227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218002228 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218002229 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218002230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218002231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002233 active site 443218002234 enoyl-CoA hydratase; Provisional; Region: PRK08260 443218002235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002236 substrate binding site [chemical binding]; other site 443218002237 oxyanion hole (OAH) forming residues; other site 443218002238 trimer interface [polypeptide binding]; other site 443218002239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002241 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218002242 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218002243 acyl-activating enzyme (AAE) consensus motif; other site 443218002244 putative AMP binding site [chemical binding]; other site 443218002245 putative active site [active] 443218002246 putative CoA binding site [chemical binding]; other site 443218002247 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218002248 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218002249 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443218002250 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443218002251 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218002252 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218002253 FMN-binding pocket [chemical binding]; other site 443218002254 flavin binding motif; other site 443218002255 phosphate binding motif [ion binding]; other site 443218002256 beta-alpha-beta structure motif; other site 443218002257 NAD binding pocket [chemical binding]; other site 443218002258 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002259 catalytic loop [active] 443218002260 iron binding site [ion binding]; other site 443218002261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218002262 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218002263 short chain dehydrogenase; Provisional; Region: PRK05872 443218002264 classical (c) SDRs; Region: SDR_c; cd05233 443218002265 NAD(P) binding site [chemical binding]; other site 443218002266 active site 443218002267 hypothetical protein; Provisional; Region: PRK04233 443218002268 SEC-C motif; Region: SEC-C; pfam02810 443218002269 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 443218002270 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218002271 classical (c) SDRs; Region: SDR_c; cd05233 443218002272 NAD(P) binding site [chemical binding]; other site 443218002273 active site 443218002274 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 443218002275 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443218002276 heme-binding site [chemical binding]; other site 443218002277 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443218002278 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443218002279 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443218002280 active site residue [active] 443218002281 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443218002282 active site residue [active] 443218002283 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 443218002284 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218002285 catalytic residues [active] 443218002286 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443218002287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218002288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218002289 DNA binding site [nucleotide binding] 443218002290 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 443218002291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218002292 Coenzyme A binding pocket [chemical binding]; other site 443218002293 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443218002294 Coenzyme A binding pocket [chemical binding]; other site 443218002295 PBP superfamily domain; Region: PBP_like_2; cl17296 443218002296 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443218002297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002298 dimer interface [polypeptide binding]; other site 443218002299 conserved gate region; other site 443218002300 putative PBP binding loops; other site 443218002301 ABC-ATPase subunit interface; other site 443218002302 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443218002303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002304 dimer interface [polypeptide binding]; other site 443218002305 conserved gate region; other site 443218002306 putative PBP binding loops; other site 443218002307 ABC-ATPase subunit interface; other site 443218002308 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443218002309 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443218002310 Walker A/P-loop; other site 443218002311 ATP binding site [chemical binding]; other site 443218002312 Q-loop/lid; other site 443218002313 ABC transporter signature motif; other site 443218002314 Walker B; other site 443218002315 D-loop; other site 443218002316 H-loop/switch region; other site 443218002317 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443218002318 PhoU domain; Region: PhoU; pfam01895 443218002319 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 443218002320 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218002321 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443218002322 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443218002323 FMN binding site [chemical binding]; other site 443218002324 active site 443218002325 catalytic residues [active] 443218002326 substrate binding site [chemical binding]; other site 443218002327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218002328 Homeodomain-like domain; Region: HTH_23; cl17451 443218002329 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443218002330 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218002331 FMN binding site [chemical binding]; other site 443218002332 substrate binding site [chemical binding]; other site 443218002333 putative catalytic residue [active] 443218002334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002336 active site 443218002337 acyl-CoA synthetase; Validated; Region: PRK08316 443218002338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218002339 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218002340 acyl-activating enzyme (AAE) consensus motif; other site 443218002341 acyl-activating enzyme (AAE) consensus motif; other site 443218002342 putative AMP binding site [chemical binding]; other site 443218002343 putative active site [active] 443218002344 putative CoA binding site [chemical binding]; other site 443218002345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002347 active site 443218002348 lipid-transfer protein; Provisional; Region: PRK08256 443218002349 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002350 active site 443218002351 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 443218002352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002354 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218002355 classical (c) SDRs; Region: SDR_c; cd05233 443218002356 NAD(P) binding site [chemical binding]; other site 443218002357 active site 443218002358 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 443218002359 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218002360 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218002361 acyl-activating enzyme (AAE) consensus motif; other site 443218002362 acyl-activating enzyme (AAE) consensus motif; other site 443218002363 putative AMP binding site [chemical binding]; other site 443218002364 putative active site [active] 443218002365 putative CoA binding site [chemical binding]; other site 443218002366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218002367 classical (c) SDRs; Region: SDR_c; cd05233 443218002368 NAD(P) binding site [chemical binding]; other site 443218002369 active site 443218002370 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218002371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002372 substrate binding site [chemical binding]; other site 443218002373 oxyanion hole (OAH) forming residues; other site 443218002374 trimer interface [polypeptide binding]; other site 443218002375 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218002376 Predicted helicase [General function prediction only]; Region: COG4889 443218002377 short chain dehydrogenase; Provisional; Region: PRK07832 443218002378 classical (c) SDRs; Region: SDR_c; cd05233 443218002379 NAD(P) binding site [chemical binding]; other site 443218002380 active site 443218002381 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443218002382 active site 443218002383 catalytic triad [active] 443218002384 oxyanion hole [active] 443218002385 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218002386 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218002387 putative NAD(P) binding site [chemical binding]; other site 443218002388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002390 Winged helix-turn helix; Region: HTH_29; pfam13551 443218002391 Homeodomain-like domain; Region: HTH_32; pfam13565 443218002392 DDE superfamily endonuclease; Region: DDE_3; pfam13358 443218002393 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218002394 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218002395 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218002396 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443218002397 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218002398 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443218002399 GAF domain; Region: GAF; cl17456 443218002400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218002401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218002402 dimerization interface [polypeptide binding]; other site 443218002403 DNA binding residues [nucleotide binding] 443218002404 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218002405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218002406 NAD(P) binding site [chemical binding]; other site 443218002407 catalytic residues [active] 443218002408 short chain dehydrogenase; Provisional; Region: PRK06197 443218002409 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218002410 putative NAD(P) binding site [chemical binding]; other site 443218002411 active site 443218002412 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443218002413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218002414 active site 443218002415 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218002416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218002417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218002418 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002420 active site 443218002421 aminotransferase; Validated; Region: PRK07777 443218002422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218002423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218002424 homodimer interface [polypeptide binding]; other site 443218002425 catalytic residue [active] 443218002426 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443218002427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002428 dimer interface [polypeptide binding]; other site 443218002429 active site 443218002430 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443218002431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002432 substrate binding site [chemical binding]; other site 443218002433 oxyanion hole (OAH) forming residues; other site 443218002434 trimer interface [polypeptide binding]; other site 443218002435 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443218002436 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218002437 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443218002438 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443218002439 Sodium Bile acid symporter family; Region: SBF; cl17470 443218002440 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443218002441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002442 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218002443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002444 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218002445 Walker A/P-loop; other site 443218002446 ATP binding site [chemical binding]; other site 443218002447 Q-loop/lid; other site 443218002448 ABC transporter signature motif; other site 443218002449 Walker B; other site 443218002450 D-loop; other site 443218002451 H-loop/switch region; other site 443218002452 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218002453 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218002454 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443218002455 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 443218002456 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443218002457 acyl-activating enzyme (AAE) consensus motif; other site 443218002458 putative AMP binding site [chemical binding]; other site 443218002459 putative active site [active] 443218002460 putative CoA binding site [chemical binding]; other site 443218002461 Putative esterase; Region: Esterase; pfam00756 443218002462 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 443218002463 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 443218002464 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218002465 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443218002466 Walker A/P-loop; other site 443218002467 ATP binding site [chemical binding]; other site 443218002468 Q-loop/lid; other site 443218002469 ABC transporter signature motif; other site 443218002470 Walker B; other site 443218002471 D-loop; other site 443218002472 H-loop/switch region; other site 443218002473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002475 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218002476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218002477 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218002478 Walker A/P-loop; other site 443218002479 ATP binding site [chemical binding]; other site 443218002480 Q-loop/lid; other site 443218002481 ABC transporter signature motif; other site 443218002482 Walker B; other site 443218002483 D-loop; other site 443218002484 H-loop/switch region; other site 443218002485 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218002486 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443218002487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002489 WHG domain; Region: WHG; pfam13305 443218002490 short chain dehydrogenase; Provisional; Region: PRK06197 443218002491 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218002492 putative NAD(P) binding site [chemical binding]; other site 443218002493 active site 443218002494 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218002495 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218002496 putative di-iron ligands [ion binding]; other site 443218002497 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218002498 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218002499 FAD binding pocket [chemical binding]; other site 443218002500 FAD binding motif [chemical binding]; other site 443218002501 phosphate binding motif [ion binding]; other site 443218002502 beta-alpha-beta structure motif; other site 443218002503 NAD binding pocket [chemical binding]; other site 443218002504 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218002505 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002506 catalytic loop [active] 443218002507 iron binding site [ion binding]; other site 443218002508 GTPase RsgA; Reviewed; Region: PRK01889 443218002509 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443218002510 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443218002511 GTP/Mg2+ binding site [chemical binding]; other site 443218002512 G4 box; other site 443218002513 G5 box; other site 443218002514 G1 box; other site 443218002515 Switch I region; other site 443218002516 G2 box; other site 443218002517 G3 box; other site 443218002518 Switch II region; other site 443218002519 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443218002520 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443218002521 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443218002522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218002523 ATP binding site [chemical binding]; other site 443218002524 putative Mg++ binding site [ion binding]; other site 443218002525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218002526 nucleotide binding region [chemical binding]; other site 443218002527 ATP-binding site [chemical binding]; other site 443218002528 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 443218002529 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 443218002530 acyl-activating enzyme (AAE) consensus motif; other site 443218002531 putative AMP binding site [chemical binding]; other site 443218002532 putative active site [active] 443218002533 putative CoA binding site [chemical binding]; other site 443218002534 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443218002535 WYL domain; Region: WYL; cl14852 443218002536 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 443218002537 trimer interface [polypeptide binding]; other site 443218002538 dimer interface [polypeptide binding]; other site 443218002539 putative active site [active] 443218002540 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443218002541 MPT binding site; other site 443218002542 trimer interface [polypeptide binding]; other site 443218002543 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443218002544 MoaE homodimer interface [polypeptide binding]; other site 443218002545 MoaD interaction [polypeptide binding]; other site 443218002546 active site residues [active] 443218002547 EAL domain; Region: EAL; pfam00563 443218002548 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 443218002549 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218002550 anti sigma factor interaction site; other site 443218002551 regulatory phosphorylation site [posttranslational modification]; other site 443218002552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 443218002553 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 443218002554 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 443218002555 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443218002556 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443218002557 MoaE interaction surface [polypeptide binding]; other site 443218002558 MoeB interaction surface [polypeptide binding]; other site 443218002559 thiocarboxylated glycine; other site 443218002560 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443218002561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218002562 FeS/SAM binding site; other site 443218002563 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443218002564 hypothetical protein; Provisional; Region: PRK11770 443218002565 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443218002566 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443218002567 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443218002568 DNA-binding site [nucleotide binding]; DNA binding site 443218002569 RNA-binding motif; other site 443218002570 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 443218002571 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 443218002572 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443218002573 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443218002574 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443218002575 active site 443218002576 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 443218002577 MarR family; Region: MarR_2; cl17246 443218002578 hypothetical protein; Provisional; Region: PRK01346 443218002579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218002580 Coenzyme A binding pocket [chemical binding]; other site 443218002581 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218002582 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443218002583 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 443218002584 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443218002585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218002586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218002587 catalytic residue [active] 443218002588 citrate synthase 2; Provisional; Region: PRK12350 443218002589 Citrate synthase; Region: Citrate_synt; pfam00285 443218002590 oxalacetate binding site [chemical binding]; other site 443218002591 citrylCoA binding site [chemical binding]; other site 443218002592 coenzyme A binding site [chemical binding]; other site 443218002593 catalytic triad [active] 443218002594 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 443218002595 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443218002596 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443218002597 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443218002598 dimer interface [polypeptide binding]; other site 443218002599 Citrate synthase; Region: Citrate_synt; pfam00285 443218002600 active site 443218002601 citrylCoA binding site [chemical binding]; other site 443218002602 NADH binding [chemical binding]; other site 443218002603 cationic pore residues; other site 443218002604 oxalacetate/citrate binding site [chemical binding]; other site 443218002605 coenzyme A binding site [chemical binding]; other site 443218002606 catalytic triad [active] 443218002607 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443218002608 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218002609 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 443218002610 DNA photolyase; Region: DNA_photolyase; pfam00875 443218002611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218002612 S-adenosylmethionine binding site [chemical binding]; other site 443218002613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218002614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218002615 dimer interface [polypeptide binding]; other site 443218002616 phosphorylation site [posttranslational modification] 443218002617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218002618 ATP binding site [chemical binding]; other site 443218002619 Mg2+ binding site [ion binding]; other site 443218002620 G-X-G motif; other site 443218002621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218002622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218002623 active site 443218002624 phosphorylation site [posttranslational modification] 443218002625 intermolecular recognition site; other site 443218002626 dimerization interface [polypeptide binding]; other site 443218002627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218002628 DNA binding site [nucleotide binding] 443218002629 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 443218002630 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443218002631 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218002632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218002633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218002634 active site 443218002635 catalytic tetrad [active] 443218002636 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218002637 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002638 substrate binding site [chemical binding]; other site 443218002639 oxyanion hole (OAH) forming residues; other site 443218002640 trimer interface [polypeptide binding]; other site 443218002641 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443218002642 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443218002643 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218002644 Protein of unknown function, DUF393; Region: DUF393; cl01136 443218002645 Secretory lipase; Region: LIP; pfam03583 443218002646 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218002647 Permease; Region: Permease; pfam02405 443218002648 Permease; Region: Permease; pfam02405 443218002649 mce related protein; Region: MCE; pfam02470 443218002650 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002651 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002652 mce related protein; Region: MCE; pfam02470 443218002653 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002654 mce related protein; Region: MCE; pfam02470 443218002655 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002656 mce related protein; Region: MCE; pfam02470 443218002657 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002658 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002659 mce related protein; Region: MCE; pfam02470 443218002660 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002661 mce related protein; Region: MCE; pfam02470 443218002662 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218002663 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 443218002664 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 443218002665 Histidine kinase; Region: His_kinase; pfam06580 443218002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218002667 ATP binding site [chemical binding]; other site 443218002668 Mg2+ binding site [ion binding]; other site 443218002669 G-X-G motif; other site 443218002670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218002671 active site 443218002672 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443218002673 substrate binding site; other site 443218002674 dimer interface; other site 443218002675 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 443218002676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218002677 active site 443218002678 phosphorylation site [posttranslational modification] 443218002679 intermolecular recognition site; other site 443218002680 dimerization interface [polypeptide binding]; other site 443218002681 LytTr DNA-binding domain; Region: LytTR; smart00850 443218002682 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443218002683 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443218002684 Na binding site [ion binding]; other site 443218002685 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443218002686 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218002687 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443218002688 Na binding site [ion binding]; other site 443218002689 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443218002690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443218002691 substrate binding pocket [chemical binding]; other site 443218002692 catalytic triad [active] 443218002693 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218002694 hydrophobic ligand binding site; other site 443218002695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002696 mce related protein; Region: MCE; pfam02470 443218002697 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002698 mce related protein; Region: MCE; pfam02470 443218002699 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002700 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002701 mce related protein; Region: MCE; pfam02470 443218002702 mce related protein; Region: MCE; pfam02470 443218002703 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002704 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002705 mce related protein; Region: MCE; pfam02470 443218002706 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218002707 mce related protein; Region: MCE; pfam02470 443218002708 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002709 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218002710 Permease; Region: Permease; pfam02405 443218002711 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218002712 Permease; Region: Permease; pfam02405 443218002713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002715 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002716 active site 443218002717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002719 active site 443218002720 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218002721 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218002722 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 443218002723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002724 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002726 active site 443218002727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002729 active site 443218002730 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218002731 active site 443218002732 catalytic site [active] 443218002733 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002734 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002735 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 443218002736 putative active site [active] 443218002737 putative catalytic site [active] 443218002738 lipid-transfer protein; Provisional; Region: PRK07855 443218002739 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002740 active site 443218002741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218002742 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218002743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218002744 active site 443218002745 AAA ATPase domain; Region: AAA_16; pfam13191 443218002746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218002747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218002748 DNA binding residues [nucleotide binding] 443218002749 dimerization interface [polypeptide binding]; other site 443218002750 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 443218002751 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 443218002752 catalytic residues [active] 443218002753 Predicted flavoprotein [General function prediction only]; Region: COG0431 443218002754 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218002755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218002756 enoyl-CoA hydratase; Region: PLN02864 443218002757 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 443218002758 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443218002759 dimer interaction site [polypeptide binding]; other site 443218002760 substrate-binding tunnel; other site 443218002761 active site 443218002762 catalytic site [active] 443218002763 substrate binding site [chemical binding]; other site 443218002764 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218002765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218002766 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218002767 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218002768 FAD binding pocket [chemical binding]; other site 443218002769 FAD binding motif [chemical binding]; other site 443218002770 phosphate binding motif [ion binding]; other site 443218002771 beta-alpha-beta structure motif; other site 443218002772 NAD(p) ribose binding residues [chemical binding]; other site 443218002773 NAD binding pocket [chemical binding]; other site 443218002774 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218002775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002776 catalytic loop [active] 443218002777 iron binding site [ion binding]; other site 443218002778 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218002779 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 443218002780 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218002781 hydrophobic ligand binding site; other site 443218002782 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 443218002783 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443218002784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002785 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 443218002786 Flavin binding site [chemical binding]; other site 443218002787 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443218002788 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218002789 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443218002790 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 443218002791 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 443218002792 active site 443218002793 Fe binding site [ion binding]; other site 443218002794 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443218002795 short chain dehydrogenase; Provisional; Region: PRK06179 443218002796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002797 NAD(P) binding site [chemical binding]; other site 443218002798 active site 443218002799 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 443218002800 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 443218002801 putative molybdopterin cofactor binding site [chemical binding]; other site 443218002802 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 443218002803 putative molybdopterin cofactor binding site; other site 443218002804 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 443218002805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218002806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218002807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443218002808 dimerization interface [polypeptide binding]; other site 443218002809 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218002810 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218002811 acyl-CoA synthetase; Validated; Region: PRK06188 443218002812 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218002813 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218002814 putative active site [active] 443218002815 putative CoA binding site [chemical binding]; other site 443218002816 putative AMP binding site [chemical binding]; other site 443218002817 lipid-transfer protein; Provisional; Region: PRK08256 443218002818 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002819 active site 443218002820 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443218002821 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002822 active site 443218002823 lipid-transfer protein; Provisional; Region: PRK07937 443218002824 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218002825 active site 443218002826 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002827 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443218002828 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002829 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002830 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002831 short chain dehydrogenase; Provisional; Region: PRK07825 443218002832 classical (c) SDRs; Region: SDR_c; cd05233 443218002833 NAD(P) binding site [chemical binding]; other site 443218002834 active site 443218002835 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 443218002836 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002837 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218002838 active site 443218002839 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002840 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002845 active site 443218002846 enoyl-CoA hydratase; Provisional; Region: PRK08290 443218002847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002848 substrate binding site [chemical binding]; other site 443218002849 oxyanion hole (OAH) forming residues; other site 443218002850 trimer interface [polypeptide binding]; other site 443218002851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443218002852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218002853 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443218002854 acyl-activating enzyme (AAE) consensus motif; other site 443218002855 putative AMP binding site [chemical binding]; other site 443218002856 putative active site [active] 443218002857 putative CoA binding site [chemical binding]; other site 443218002858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002860 active site 443218002861 short chain dehydrogenase; Provisional; Region: PRK07831 443218002862 classical (c) SDRs; Region: SDR_c; cd05233 443218002863 NAD(P) binding site [chemical binding]; other site 443218002864 active site 443218002865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002867 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 443218002868 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002869 dimer interface [polypeptide binding]; other site 443218002870 active site 443218002871 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218002872 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218002873 Walker A/P-loop; other site 443218002874 ATP binding site [chemical binding]; other site 443218002875 Q-loop/lid; other site 443218002876 ABC transporter signature motif; other site 443218002877 Walker B; other site 443218002878 D-loop; other site 443218002879 H-loop/switch region; other site 443218002880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218002881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002882 dimer interface [polypeptide binding]; other site 443218002883 conserved gate region; other site 443218002884 putative PBP binding loops; other site 443218002885 ABC-ATPase subunit interface; other site 443218002886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002887 dimer interface [polypeptide binding]; other site 443218002888 conserved gate region; other site 443218002889 putative PBP binding loops; other site 443218002890 ABC-ATPase subunit interface; other site 443218002891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218002892 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218002893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218002894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218002895 DNA binding site [nucleotide binding] 443218002896 domain linker motif; other site 443218002897 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218002898 ligand binding site [chemical binding]; other site 443218002899 dimerization interface [polypeptide binding]; other site 443218002900 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218002901 Nitronate monooxygenase; Region: NMO; pfam03060 443218002902 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218002903 FMN binding site [chemical binding]; other site 443218002904 substrate binding site [chemical binding]; other site 443218002905 putative catalytic residue [active] 443218002906 Coenzyme A transferase; Region: CoA_trans; cl17247 443218002907 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443218002908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002909 enoyl-CoA hydratase; Provisional; Region: PRK06495 443218002910 substrate binding site [chemical binding]; other site 443218002911 oxyanion hole (OAH) forming residues; other site 443218002912 trimer interface [polypeptide binding]; other site 443218002913 short chain dehydrogenase; Provisional; Region: PRK07856 443218002914 classical (c) SDRs; Region: SDR_c; cd05233 443218002915 NAD(P) binding site [chemical binding]; other site 443218002916 active site 443218002917 short chain dehydrogenase; Provisional; Region: PRK07791 443218002918 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443218002919 homodimer interface [polypeptide binding]; other site 443218002920 NAD binding site [chemical binding]; other site 443218002921 active site 443218002922 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443218002923 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443218002924 active site 443218002925 FMN binding site [chemical binding]; other site 443218002926 substrate binding site [chemical binding]; other site 443218002927 putative catalytic residue [active] 443218002928 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218002929 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 443218002930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002931 dimer interface [polypeptide binding]; other site 443218002932 active site 443218002933 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218002934 Cytochrome P450; Region: p450; cl12078 443218002935 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218002936 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443218002937 [2Fe-2S] cluster binding site [ion binding]; other site 443218002938 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 443218002939 putative alpha subunit interface [polypeptide binding]; other site 443218002940 putative active site [active] 443218002941 putative substrate binding site [chemical binding]; other site 443218002942 Fe binding site [ion binding]; other site 443218002943 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218002944 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218002945 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218002946 homodimer interface [polypeptide binding]; other site 443218002947 NADP binding site [chemical binding]; other site 443218002948 substrate binding site [chemical binding]; other site 443218002949 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218002950 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218002951 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 443218002952 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 443218002953 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002954 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443218002955 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443218002956 glutamine binding [chemical binding]; other site 443218002957 catalytic triad [active] 443218002958 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 443218002959 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443218002960 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443218002961 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443218002962 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218002963 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218002964 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 443218002965 FAD binding site [chemical binding]; other site 443218002966 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218002967 dihydropteroate synthase; Region: DHPS; TIGR01496 443218002968 substrate binding pocket [chemical binding]; other site 443218002969 inhibitor binding site; inhibition site 443218002970 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218002971 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218002972 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218002973 homodimer interface [polypeptide binding]; other site 443218002974 NADP binding site [chemical binding]; other site 443218002975 substrate binding site [chemical binding]; other site 443218002976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218002977 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443218002978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218002979 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 443218002980 [2Fe-2S] cluster binding site [ion binding]; other site 443218002981 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443218002982 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218002983 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218002984 BCCT family transporter; Region: BCCT; pfam02028 443218002985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218002986 dimerization interface [polypeptide binding]; other site 443218002987 putative DNA binding site [nucleotide binding]; other site 443218002988 putative Zn2+ binding site [ion binding]; other site 443218002989 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443218002990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218002991 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443218002992 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218002993 Cytochrome P450; Region: p450; cl12078 443218002994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218002995 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443218002996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002997 active site 443218002998 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002999 lipid-transfer protein; Provisional; Region: PRK07937 443218003000 active site 443218003001 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218003002 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218003003 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218003004 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443218003005 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218003006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218003007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218003008 enoyl-CoA hydratase; Provisional; Region: PRK07799 443218003009 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218003010 substrate binding site [chemical binding]; other site 443218003011 oxyanion hole (OAH) forming residues; other site 443218003012 trimer interface [polypeptide binding]; other site 443218003013 acyl-CoA synthetase; Validated; Region: PRK07798 443218003014 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218003015 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 443218003016 acyl-activating enzyme (AAE) consensus motif; other site 443218003017 acyl-activating enzyme (AAE) consensus motif; other site 443218003018 putative AMP binding site [chemical binding]; other site 443218003019 putative active site [active] 443218003020 putative CoA binding site [chemical binding]; other site 443218003021 Nitronate monooxygenase; Region: NMO; pfam03060 443218003022 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218003023 FMN binding site [chemical binding]; other site 443218003024 substrate binding site [chemical binding]; other site 443218003025 putative catalytic residue [active] 443218003026 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 443218003027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218003028 NAD binding site [chemical binding]; other site 443218003029 catalytic residues [active] 443218003030 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218003031 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443218003032 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443218003033 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 443218003034 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443218003035 lipoyl attachment site [posttranslational modification]; other site 443218003036 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 443218003037 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 443218003038 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 443218003039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218003040 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443218003041 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218003042 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 443218003043 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 443218003044 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218003045 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218003046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218003047 dimer interface [polypeptide binding]; other site 443218003048 active site 443218003049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218003050 folate binding site [chemical binding]; other site 443218003051 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218003052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 443218003053 FCD domain; Region: FCD; pfam07729 443218003054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218003055 S-adenosylmethionine binding site [chemical binding]; other site 443218003056 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 443218003057 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443218003058 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443218003059 putative active site [active] 443218003060 putative substrate binding site [chemical binding]; other site 443218003061 putative cosubstrate binding site; other site 443218003062 catalytic site [active] 443218003063 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218003064 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218003065 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 443218003066 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218003067 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443218003068 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218003069 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218003070 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218003071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218003072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218003073 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 443218003074 [2Fe-2S] cluster binding site [ion binding]; other site 443218003075 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443218003076 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218003077 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218003078 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218003079 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443218003080 [2Fe-2S] cluster binding site [ion binding]; other site 443218003081 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218003082 hydrophobic ligand binding site; other site 443218003083 BCCT family transporter; Region: BCCT; pfam02028 443218003084 choline dehydrogenase; Validated; Region: PRK02106 443218003085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218003086 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218003087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218003088 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218003089 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218003090 active site 443218003091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218003092 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443218003093 FAD binding site [chemical binding]; other site 443218003094 substrate binding site [chemical binding]; other site 443218003095 catalytic base [active] 443218003096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003097 NAD(P) binding site [chemical binding]; other site 443218003098 active site 443218003099 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 443218003100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003101 NAD(P) binding site [chemical binding]; other site 443218003102 active site 443218003103 hypothetical protein; Validated; Region: PRK07121 443218003104 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443218003105 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443218003106 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443218003107 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443218003108 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443218003109 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443218003110 active site 443218003111 catalytic residues [active] 443218003112 metal binding site [ion binding]; metal-binding site 443218003113 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443218003114 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 443218003115 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443218003116 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 443218003117 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443218003118 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 443218003119 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218003120 dimer interface [polypeptide binding]; other site 443218003121 PYR/PP interface [polypeptide binding]; other site 443218003122 TPP binding site [chemical binding]; other site 443218003123 substrate binding site [chemical binding]; other site 443218003124 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443218003125 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443218003126 TPP-binding site [chemical binding]; other site 443218003127 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 443218003128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218003129 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443218003130 putative DNA binding site [nucleotide binding]; other site 443218003131 putative Zn2+ binding site [ion binding]; other site 443218003132 AsnC family; Region: AsnC_trans_reg; pfam01037 443218003133 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 443218003134 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218003135 dimer interface [polypeptide binding]; other site 443218003136 PYR/PP interface [polypeptide binding]; other site 443218003137 TPP binding site [chemical binding]; other site 443218003138 substrate binding site [chemical binding]; other site 443218003139 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443218003140 TPP-binding site; other site 443218003141 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443218003142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218003143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443218003144 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218003145 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443218003146 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443218003147 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218003148 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218003149 putative active site [active] 443218003150 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 443218003151 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443218003152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443218003153 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443218003154 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 443218003155 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443218003156 catalytic site [active] 443218003157 putative active site [active] 443218003158 putative substrate binding site [chemical binding]; other site 443218003159 dimer interface [polypeptide binding]; other site 443218003160 acyl-CoA synthetase; Validated; Region: PRK07788 443218003161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218003162 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218003163 acyl-activating enzyme (AAE) consensus motif; other site 443218003164 putative AMP binding site [chemical binding]; other site 443218003165 putative active site [active] 443218003166 putative CoA binding site [chemical binding]; other site 443218003167 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003169 NAD(P) binding site [chemical binding]; other site 443218003170 active site 443218003171 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 443218003172 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218003173 catalytic Zn binding site [ion binding]; other site 443218003174 NAD(P) binding site [chemical binding]; other site 443218003175 structural Zn binding site [ion binding]; other site 443218003176 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443218003177 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443218003178 active site 443218003179 FMN binding site [chemical binding]; other site 443218003180 2,4-decadienoyl-CoA binding site; other site 443218003181 catalytic residue [active] 443218003182 4Fe-4S cluster binding site [ion binding]; other site 443218003183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218003184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218003185 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218003186 Transcriptional regulator PadR-like family; Region: PadR; cl17335 443218003187 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218003188 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 443218003189 putative ADP-ribose binding site [chemical binding]; other site 443218003190 putative active site [active] 443218003191 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443218003192 Fasciclin domain; Region: Fasciclin; pfam02469 443218003193 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443218003194 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 443218003195 Moco binding site; other site 443218003196 metal coordination site [ion binding]; other site 443218003197 dimerization interface [polypeptide binding]; other site 443218003198 Putative zinc-finger; Region: zf-HC2; pfam13490 443218003199 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443218003200 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443218003201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218003202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218003203 DNA binding residues [nucleotide binding] 443218003204 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 443218003205 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443218003206 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218003207 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218003208 Copper resistance protein D; Region: CopD; cl00563 443218003209 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 443218003210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443218003211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443218003212 dimer interface [polypeptide binding]; other site 443218003213 ssDNA binding site [nucleotide binding]; other site 443218003214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443218003215 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443218003216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218003217 Walker A/P-loop; other site 443218003218 ATP binding site [chemical binding]; other site 443218003219 Q-loop/lid; other site 443218003220 ABC transporter signature motif; other site 443218003221 Walker B; other site 443218003222 D-loop; other site 443218003223 H-loop/switch region; other site 443218003224 ABC transporter; Region: ABC_tran_2; pfam12848 443218003225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218003226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218003227 active site 443218003228 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218003229 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218003230 active site 443218003231 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443218003232 apolar tunnel; other site 443218003233 heme binding site [chemical binding]; other site 443218003234 dimerization interface [polypeptide binding]; other site 443218003235 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443218003236 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443218003237 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003238 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443218003239 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218003240 active site 443218003241 Repair protein; Region: Repair_PSII; cl01535 443218003242 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443218003243 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443218003244 Zn binding site [ion binding]; other site 443218003245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443218003246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218003247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218003248 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 443218003249 Na binding site [ion binding]; other site 443218003250 putative glycosylation site [posttranslational modification]; other site 443218003251 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 443218003252 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443218003253 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443218003254 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 443218003255 urea carboxylase; Region: urea_carbox; TIGR02712 443218003256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218003257 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218003258 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 443218003259 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 443218003260 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 443218003261 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218003262 carboxyltransferase (CT) interaction site; other site 443218003263 biotinylation site [posttranslational modification]; other site 443218003264 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 443218003265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218003266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443218003267 Coenzyme A binding pocket [chemical binding]; other site 443218003268 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218003269 active site 443218003270 catalytic triad [active] 443218003271 oxyanion hole [active] 443218003272 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443218003273 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443218003274 catalytic residues [active] 443218003275 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 443218003276 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443218003277 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443218003278 putative DNA binding site [nucleotide binding]; other site 443218003279 putative catalytic residues [active] 443218003280 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218003281 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218003282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218003283 Predicted acetyltransferase [General function prediction only]; Region: COG2388 443218003284 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 443218003285 trigger factor; Provisional; Region: tig; PRK01490 443218003286 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443218003287 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443218003288 Clp protease; Region: CLP_protease; pfam00574 443218003289 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443218003290 oligomer interface [polypeptide binding]; other site 443218003291 active site residues [active] 443218003292 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443218003293 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443218003294 oligomer interface [polypeptide binding]; other site 443218003295 active site residues [active] 443218003296 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443218003297 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443218003298 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443218003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218003300 Walker A motif; other site 443218003301 ATP binding site [chemical binding]; other site 443218003302 Walker B motif; other site 443218003303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443218003304 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443218003305 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443218003306 trimer interface [polypeptide binding]; other site 443218003307 active site 443218003308 dimer interface [polypeptide binding]; other site 443218003309 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443218003310 GTP binding site; other site 443218003311 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 443218003312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218003313 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443218003314 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443218003315 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 443218003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003317 dimer interface [polypeptide binding]; other site 443218003318 conserved gate region; other site 443218003319 putative PBP binding loops; other site 443218003320 ABC-ATPase subunit interface; other site 443218003321 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 443218003322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443218003323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003324 dimer interface [polypeptide binding]; other site 443218003325 conserved gate region; other site 443218003326 putative PBP binding loops; other site 443218003327 ABC-ATPase subunit interface; other site 443218003328 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443218003329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443218003330 Walker A/P-loop; other site 443218003331 ATP binding site [chemical binding]; other site 443218003332 Q-loop/lid; other site 443218003333 ABC transporter signature motif; other site 443218003334 Walker B; other site 443218003335 D-loop; other site 443218003336 H-loop/switch region; other site 443218003337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443218003338 Walker A/P-loop; other site 443218003339 ATP binding site [chemical binding]; other site 443218003340 Q-loop/lid; other site 443218003341 ABC transporter signature motif; other site 443218003342 Walker B; other site 443218003343 D-loop; other site 443218003344 H-loop/switch region; other site 443218003345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443218003346 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003347 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218003348 siderophore binding site; other site 443218003349 Histone acetyltransferase [Transcription / Chromatin structure and dynamics]; Region: ELP3; COG1243 443218003350 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218003351 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218003352 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218003353 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218003354 Secretory lipase; Region: LIP; pfam03583 443218003355 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 443218003356 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 443218003357 Domain of unknown function DUF87; Region: DUF87; pfam01935 443218003358 AAA-like domain; Region: AAA_10; pfam12846 443218003359 Pirin-related protein [General function prediction only]; Region: COG1741 443218003360 Pirin; Region: Pirin; pfam02678 443218003361 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443218003362 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 443218003363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 443218003364 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443218003365 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 443218003366 dimer interface [polypeptide binding]; other site 443218003367 active site 443218003368 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218003369 catalytic residues [active] 443218003370 substrate binding site [chemical binding]; other site 443218003371 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443218003372 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443218003373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218003374 catalytic residue [active] 443218003375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218003376 active site residue [active] 443218003377 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218003378 Aminotransferase class-V; Region: Aminotran_5; pfam00266 443218003379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218003380 catalytic residue [active] 443218003381 hypothetical protein; Provisional; Region: PRK07206 443218003382 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 443218003383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218003384 S-adenosylmethionine binding site [chemical binding]; other site 443218003385 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218003386 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218003387 Serine hydrolase; Region: Ser_hydrolase; cl17834 443218003388 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218003389 Protein kinase domain; Region: Pkinase; pfam00069 443218003390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003391 active site 443218003392 ATP binding site [chemical binding]; other site 443218003393 substrate binding site [chemical binding]; other site 443218003394 activation loop (A-loop); other site 443218003395 AAA ATPase domain; Region: AAA_16; pfam13191 443218003396 AAA domain; Region: AAA_22; pfam13401 443218003397 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443218003398 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443218003399 HIGH motif; other site 443218003400 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443218003401 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443218003402 active site 443218003403 KMSKS motif; other site 443218003404 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443218003405 tRNA binding surface [nucleotide binding]; other site 443218003406 anticodon binding site; other site 443218003407 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443218003408 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443218003409 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003410 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003411 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443218003412 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443218003413 multimer interface [polypeptide binding]; other site 443218003414 active site 443218003415 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443218003416 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443218003417 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443218003418 homodimer interface [polypeptide binding]; other site 443218003419 oligonucleotide binding site [chemical binding]; other site 443218003420 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 443218003421 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443218003422 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 443218003423 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443218003424 GTP1/OBG; Region: GTP1_OBG; pfam01018 443218003425 Obg GTPase; Region: Obg; cd01898 443218003426 G1 box; other site 443218003427 GTP/Mg2+ binding site [chemical binding]; other site 443218003428 Switch I region; other site 443218003429 G2 box; other site 443218003430 G3 box; other site 443218003431 Switch II region; other site 443218003432 G4 box; other site 443218003433 G5 box; other site 443218003434 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 443218003435 gamma-glutamyl kinase; Provisional; Region: PRK05429 443218003436 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443218003437 nucleotide binding site [chemical binding]; other site 443218003438 homotetrameric interface [polypeptide binding]; other site 443218003439 putative phosphate binding site [ion binding]; other site 443218003440 putative allosteric binding site; other site 443218003441 PUA domain; Region: PUA; pfam01472 443218003442 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443218003443 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443218003444 active site 443218003445 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443218003446 arsenical-resistance protein; Region: acr3; TIGR00832 443218003447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218003448 dimerization interface [polypeptide binding]; other site 443218003449 putative DNA binding site [nucleotide binding]; other site 443218003450 putative Zn2+ binding site [ion binding]; other site 443218003451 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 443218003452 NAD-dependent deacetylase; Provisional; Region: PRK00481 443218003453 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 443218003454 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 443218003455 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218003456 inhibitor-cofactor binding pocket; inhibition site 443218003457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003458 catalytic residue [active] 443218003459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218003460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218003461 Coenzyme A binding pocket [chemical binding]; other site 443218003462 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218003463 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 443218003464 substrate binding site [chemical binding]; other site 443218003465 dimer interface [polypeptide binding]; other site 443218003466 ATP binding site [chemical binding]; other site 443218003467 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443218003468 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443218003469 putative catalytic cysteine [active] 443218003470 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443218003471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218003472 Walker A motif; other site 443218003473 ATP binding site [chemical binding]; other site 443218003474 Walker B motif; other site 443218003475 arginine finger; other site 443218003476 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218003477 metal ion-dependent adhesion site (MIDAS); other site 443218003478 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443218003479 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443218003480 active site 443218003481 (T/H)XGH motif; other site 443218003482 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 443218003483 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218003484 catalytic core [active] 443218003485 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443218003486 catalytic triad [active] 443218003487 EDD domain protein, DegV family; Region: DegV; TIGR00762 443218003488 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 443218003489 SLBB domain; Region: SLBB; pfam10531 443218003490 comEA protein; Region: comE; TIGR01259 443218003491 Helix-hairpin-helix motif; Region: HHH; pfam00633 443218003492 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443218003493 Competence protein; Region: Competence; pfam03772 443218003494 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218003495 hypothetical protein; Reviewed; Region: PRK07914 443218003496 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443218003497 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 443218003498 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 443218003499 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443218003500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443218003501 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443218003502 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443218003503 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443218003504 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443218003505 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443218003506 amidase catalytic site [active] 443218003507 Zn binding residues [ion binding]; other site 443218003508 substrate binding site [chemical binding]; other site 443218003509 GTP-binding protein LepA; Provisional; Region: PRK05433 443218003510 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443218003511 G1 box; other site 443218003512 putative GEF interaction site [polypeptide binding]; other site 443218003513 GTP/Mg2+ binding site [chemical binding]; other site 443218003514 Switch I region; other site 443218003515 G2 box; other site 443218003516 G3 box; other site 443218003517 Switch II region; other site 443218003518 G4 box; other site 443218003519 G5 box; other site 443218003520 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443218003521 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443218003522 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443218003523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218003524 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 443218003525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218003526 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 443218003527 NAD(P) binding site [chemical binding]; other site 443218003528 catalytic residues [active] 443218003529 choline dehydrogenase; Validated; Region: PRK02106 443218003530 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218003531 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218003532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218003533 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218003534 iron-sulfur cluster [ion binding]; other site 443218003535 [2Fe-2S] cluster binding site [ion binding]; other site 443218003536 classical (c) SDRs; Region: SDR_c; cd05233 443218003537 short chain dehydrogenase; Provisional; Region: PRK05650 443218003538 NAD(P) binding site [chemical binding]; other site 443218003539 active site 443218003540 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003541 mce related protein; Region: MCE; pfam02470 443218003542 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003543 mce related protein; Region: MCE; pfam02470 443218003544 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003545 mce related protein; Region: MCE; pfam02470 443218003546 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003547 mce related protein; Region: MCE; pfam02470 443218003548 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218003549 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003550 mce related protein; Region: MCE; pfam02470 443218003551 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218003552 mce related protein; Region: MCE; pfam02470 443218003553 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218003554 Permease; Region: Permease; pfam02405 443218003555 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443218003556 Permease; Region: Permease; pfam02405 443218003557 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218003558 hydrophobic ligand binding site; other site 443218003559 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443218003560 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218003561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218003562 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218003563 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218003564 acyl-activating enzyme (AAE) consensus motif; other site 443218003565 putative AMP binding site [chemical binding]; other site 443218003566 putative active site [active] 443218003567 putative CoA binding site [chemical binding]; other site 443218003568 Nitronate monooxygenase; Region: NMO; pfam03060 443218003569 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218003570 FMN binding site [chemical binding]; other site 443218003571 substrate binding site [chemical binding]; other site 443218003572 putative catalytic residue [active] 443218003573 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443218003574 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003575 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218003576 intersubunit interface [polypeptide binding]; other site 443218003577 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218003578 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218003579 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443218003580 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443218003581 sulfate transport protein; Provisional; Region: cysT; CHL00187 443218003582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003583 dimer interface [polypeptide binding]; other site 443218003584 conserved gate region; other site 443218003585 putative PBP binding loops; other site 443218003586 ABC-ATPase subunit interface; other site 443218003587 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443218003588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003589 dimer interface [polypeptide binding]; other site 443218003590 conserved gate region; other site 443218003591 putative PBP binding loops; other site 443218003592 ABC-ATPase subunit interface; other site 443218003593 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 443218003594 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 443218003595 Walker A/P-loop; other site 443218003596 ATP binding site [chemical binding]; other site 443218003597 Q-loop/lid; other site 443218003598 ABC transporter signature motif; other site 443218003599 Walker B; other site 443218003600 D-loop; other site 443218003601 H-loop/switch region; other site 443218003602 TOBE-like domain; Region: TOBE_3; pfam12857 443218003603 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 443218003604 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443218003605 CysD dimerization site [polypeptide binding]; other site 443218003606 G1 box; other site 443218003607 putative GEF interaction site [polypeptide binding]; other site 443218003608 GTP/Mg2+ binding site [chemical binding]; other site 443218003609 Switch I region; other site 443218003610 G2 box; other site 443218003611 G3 box; other site 443218003612 Switch II region; other site 443218003613 G4 box; other site 443218003614 G5 box; other site 443218003615 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443218003616 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443218003617 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443218003618 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218003619 Active Sites [active] 443218003620 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 443218003621 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218003622 Active Sites [active] 443218003623 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 443218003624 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218003625 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218003626 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443218003627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218003628 FeS/SAM binding site; other site 443218003629 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443218003630 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 443218003631 chaperone protein DnaJ; Provisional; Region: PRK14278 443218003632 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443218003633 HSP70 interaction site [polypeptide binding]; other site 443218003634 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443218003635 Zn binding sites [ion binding]; other site 443218003636 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443218003637 dimer interface [polypeptide binding]; other site 443218003638 RNA methyltransferase, RsmE family; Region: TIGR00046 443218003639 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 443218003640 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443218003641 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443218003642 PhoH-like protein; Region: PhoH; pfam02562 443218003643 metal-binding heat shock protein; Provisional; Region: PRK00016 443218003644 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218003645 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218003646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218003647 Transporter associated domain; Region: CorC_HlyC; smart01091 443218003648 GTPase Era; Reviewed; Region: era; PRK00089 443218003649 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443218003650 G1 box; other site 443218003651 GTP/Mg2+ binding site [chemical binding]; other site 443218003652 Switch I region; other site 443218003653 G2 box; other site 443218003654 Switch II region; other site 443218003655 G3 box; other site 443218003656 G4 box; other site 443218003657 G5 box; other site 443218003658 KH domain; Region: KH_2; pfam07650 443218003659 PBP superfamily domain; Region: PBP_like_2; cl17296 443218003660 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 443218003661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003662 dimer interface [polypeptide binding]; other site 443218003663 conserved gate region; other site 443218003664 putative PBP binding loops; other site 443218003665 ABC-ATPase subunit interface; other site 443218003666 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 443218003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003668 dimer interface [polypeptide binding]; other site 443218003669 conserved gate region; other site 443218003670 putative PBP binding loops; other site 443218003671 ABC-ATPase subunit interface; other site 443218003672 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 443218003673 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443218003674 Walker A/P-loop; other site 443218003675 ATP binding site [chemical binding]; other site 443218003676 Q-loop/lid; other site 443218003677 ABC transporter signature motif; other site 443218003678 Walker B; other site 443218003679 D-loop; other site 443218003680 H-loop/switch region; other site 443218003681 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 443218003682 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443218003683 Walker A/P-loop; other site 443218003684 ATP binding site [chemical binding]; other site 443218003685 Q-loop/lid; other site 443218003686 ABC transporter signature motif; other site 443218003687 Walker B; other site 443218003688 D-loop; other site 443218003689 H-loop/switch region; other site 443218003690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218003691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218003692 active site 443218003693 phosphorylation site [posttranslational modification] 443218003694 intermolecular recognition site; other site 443218003695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218003696 DNA binding site [nucleotide binding] 443218003697 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443218003698 Recombination protein O N terminal; Region: RecO_N; pfam11967 443218003699 Recombination protein O C terminal; Region: RecO_C; pfam02565 443218003700 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443218003701 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443218003702 catalytic residue [active] 443218003703 putative FPP diphosphate binding site; other site 443218003704 putative FPP binding hydrophobic cleft; other site 443218003705 dimer interface [polypeptide binding]; other site 443218003706 putative IPP diphosphate binding site; other site 443218003707 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218003708 metal binding site 2 [ion binding]; metal-binding site 443218003709 putative DNA binding helix; other site 443218003710 metal binding site 1 [ion binding]; metal-binding site 443218003711 dimer interface [polypeptide binding]; other site 443218003712 structural Zn2+ binding site [ion binding]; other site 443218003713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218003714 dimerization interface [polypeptide binding]; other site 443218003715 putative DNA binding site [nucleotide binding]; other site 443218003716 putative Zn2+ binding site [ion binding]; other site 443218003717 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443218003718 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443218003719 motif 1; other site 443218003720 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 443218003721 active site 443218003722 motif 2; other site 443218003723 motif 3; other site 443218003724 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443218003725 anticodon binding site; other site 443218003726 Repair protein; Region: Repair_PSII; pfam04536 443218003727 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218003728 putative active site [active] 443218003729 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443218003730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443218003731 Zn2+ binding site [ion binding]; other site 443218003732 Mg2+ binding site [ion binding]; other site 443218003733 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443218003734 DNA primase; Validated; Region: dnaG; PRK05667 443218003735 CHC2 zinc finger; Region: zf-CHC2; cl17510 443218003736 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443218003737 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443218003738 active site 443218003739 metal binding site [ion binding]; metal-binding site 443218003740 interdomain interaction site; other site 443218003741 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443218003742 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 443218003743 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218003744 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218003745 active site 443218003746 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218003747 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218003748 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443218003749 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218003750 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443218003751 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218003752 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443218003753 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443218003754 dimer interface [polypeptide binding]; other site 443218003755 active site 443218003756 acyl carrier protein; Provisional; Region: acpP; PRK00982 443218003757 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443218003758 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218003759 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218003760 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218003761 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443218003762 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443218003763 dimer interface [polypeptide binding]; other site 443218003764 TPP-binding site [chemical binding]; other site 443218003765 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 443218003766 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443218003767 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443218003768 dimer interface [polypeptide binding]; other site 443218003769 catalytic triad [active] 443218003770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218003771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003772 active site 443218003773 ATP binding site [chemical binding]; other site 443218003774 substrate binding site [chemical binding]; other site 443218003775 activation loop (A-loop); other site 443218003776 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218003777 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443218003778 IncA protein; Region: IncA; pfam04156 443218003779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218003780 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443218003781 Walker A/P-loop; other site 443218003782 ATP binding site [chemical binding]; other site 443218003783 Q-loop/lid; other site 443218003784 ABC transporter signature motif; other site 443218003785 Walker B; other site 443218003786 D-loop; other site 443218003787 H-loop/switch region; other site 443218003788 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443218003789 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443218003790 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443218003791 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443218003792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218003793 active site 443218003794 motif I; other site 443218003795 motif II; other site 443218003796 hypothetical protein; Provisional; Region: PRK07908 443218003797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218003798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003799 homodimer interface [polypeptide binding]; other site 443218003800 catalytic residue [active] 443218003801 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443218003802 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443218003803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443218003804 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443218003805 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443218003806 Putative zinc ribbon domain; Region: DUF164; pfam02591 443218003807 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 443218003808 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443218003809 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218003810 active site 443218003811 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218003812 catalytic core [active] 443218003813 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218003814 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 443218003815 amidase catalytic site [active] 443218003816 Zn binding residues [ion binding]; other site 443218003817 substrate binding site [chemical binding]; other site 443218003818 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443218003819 putative active site; other site 443218003820 putative metal binding residues [ion binding]; other site 443218003821 signature motif; other site 443218003822 putative triphosphate binding site [ion binding]; other site 443218003823 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443218003824 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443218003825 oligomerization interface [polypeptide binding]; other site 443218003826 active site 443218003827 metal binding site [ion binding]; metal-binding site 443218003828 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218003829 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218003830 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443218003831 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443218003832 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443218003833 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 443218003834 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218003835 metal binding triad; other site 443218003836 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218003837 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218003838 metal binding triad; other site 443218003839 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218003840 glutamine synthetase, type I; Region: GlnA; TIGR00653 443218003841 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443218003842 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443218003843 RDD family; Region: RDD; pfam06271 443218003844 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443218003845 lipoyl synthase; Provisional; Region: PRK05481 443218003846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218003847 FeS/SAM binding site; other site 443218003848 lipoate-protein ligase B; Provisional; Region: PRK14345 443218003849 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 443218003850 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 443218003851 putative NAD(P) binding site [chemical binding]; other site 443218003852 putative active site [active] 443218003853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218003854 E3 interaction surface; other site 443218003855 lipoyl attachment site [posttranslational modification]; other site 443218003856 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218003857 E3 interaction surface; other site 443218003858 lipoyl attachment site [posttranslational modification]; other site 443218003859 e3 binding domain; Region: E3_binding; pfam02817 443218003860 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443218003861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443218003862 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443218003863 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443218003864 interface (dimer of trimers) [polypeptide binding]; other site 443218003865 Substrate-binding/catalytic site; other site 443218003866 Zn-binding sites [ion binding]; other site 443218003867 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443218003868 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218003869 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443218003870 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443218003871 homodimer interface [polypeptide binding]; other site 443218003872 substrate-cofactor binding pocket; other site 443218003873 catalytic residue [active] 443218003874 cobalamin synthase; Reviewed; Region: cobS; PRK00235 443218003875 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443218003876 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443218003877 putative dimer interface [polypeptide binding]; other site 443218003878 active site pocket [active] 443218003879 putative cataytic base [active] 443218003880 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443218003881 homotrimer interface [polypeptide binding]; other site 443218003882 Walker A motif; other site 443218003883 GTP binding site [chemical binding]; other site 443218003884 Walker B motif; other site 443218003885 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443218003886 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 443218003887 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 443218003888 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218003889 substrate binding site [chemical binding]; other site 443218003890 ATP binding site [chemical binding]; other site 443218003891 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443218003892 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443218003893 active site 443218003894 dimer interface [polypeptide binding]; other site 443218003895 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443218003896 Ligand Binding Site [chemical binding]; other site 443218003897 Molecular Tunnel; other site 443218003898 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 443218003899 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443218003900 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443218003901 Predicted permease; Region: DUF318; cl17795 443218003902 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 443218003903 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443218003904 Qi binding site; other site 443218003905 intrachain domain interface; other site 443218003906 interchain domain interface [polypeptide binding]; other site 443218003907 heme bH binding site [chemical binding]; other site 443218003908 heme bL binding site [chemical binding]; other site 443218003909 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 443218003910 Qo binding site; other site 443218003911 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443218003912 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443218003913 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218003914 iron-sulfur cluster [ion binding]; other site 443218003915 [2Fe-2S] cluster binding site [ion binding]; other site 443218003916 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443218003917 Cytochrome c; Region: Cytochrom_C; pfam00034 443218003918 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443218003919 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443218003920 Subunit I/III interface [polypeptide binding]; other site 443218003921 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443218003922 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443218003923 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443218003924 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218003925 AsnC family; Region: AsnC_trans_reg; pfam01037 443218003926 hypothetical protein; Validated; Region: PRK07883 443218003927 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443218003928 active site 443218003929 catalytic site [active] 443218003930 substrate binding site [chemical binding]; other site 443218003931 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443218003932 GIY-YIG motif/motif A; other site 443218003933 active site 443218003934 catalytic site [active] 443218003935 putative DNA binding site [nucleotide binding]; other site 443218003936 metal binding site [ion binding]; metal-binding site 443218003937 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218003938 NlpC/P60 family; Region: NLPC_P60; pfam00877 443218003939 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218003940 NlpC/P60 family; Region: NLPC_P60; pfam00877 443218003941 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443218003942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218003943 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218003944 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218003945 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218003946 acyl-activating enzyme (AAE) consensus motif; other site 443218003947 putative AMP binding site [chemical binding]; other site 443218003948 putative active site [active] 443218003949 putative CoA binding site [chemical binding]; other site 443218003950 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443218003951 putative hydrophobic ligand binding site [chemical binding]; other site 443218003952 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443218003953 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218003954 DTAP/Switch II; other site 443218003955 Switch I; other site 443218003956 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 443218003957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443218003958 nucleotide binding site [chemical binding]; other site 443218003959 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218003960 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218003961 putative acyl-acceptor binding pocket; other site 443218003962 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 443218003963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003964 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218003965 active site 443218003966 ATP binding site [chemical binding]; other site 443218003967 substrate binding site [chemical binding]; other site 443218003968 activation loop (A-loop); other site 443218003969 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003970 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003971 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003972 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003973 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443218003974 active site lid residues [active] 443218003975 substrate binding pocket [chemical binding]; other site 443218003976 catalytic residues [active] 443218003977 substrate-Mg2+ binding site; other site 443218003978 aspartate-rich region 1; other site 443218003979 aspartate-rich region 2; other site 443218003980 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443218003981 phytoene desaturase; Region: crtI_fam; TIGR02734 443218003982 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443218003983 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443218003984 substrate binding pocket [chemical binding]; other site 443218003985 chain length determination region; other site 443218003986 substrate-Mg2+ binding site; other site 443218003987 catalytic residues [active] 443218003988 aspartate-rich region 1; other site 443218003989 active site lid residues [active] 443218003990 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443218003991 aspartate-rich region 2; other site 443218003992 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443218003993 FAD binding site [chemical binding]; other site 443218003994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218003995 active site 443218003996 Protein of unknown function (DUF422); Region: DUF422; pfam04240 443218003997 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218003998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218003999 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443218004000 Coenzyme A binding pocket [chemical binding]; other site 443218004001 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 443218004002 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443218004003 cell division protein MraZ; Reviewed; Region: PRK00326 443218004004 MraZ protein; Region: MraZ; pfam02381 443218004005 MraZ protein; Region: MraZ; pfam02381 443218004006 MraW methylase family; Region: Methyltransf_5; cl17771 443218004007 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 443218004008 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443218004009 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443218004010 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218004011 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443218004012 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218004013 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218004014 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218004015 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 443218004016 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218004017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218004018 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218004019 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443218004020 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443218004021 Mg++ binding site [ion binding]; other site 443218004022 putative catalytic motif [active] 443218004023 putative substrate binding site [chemical binding]; other site 443218004024 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218004025 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 443218004026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218004027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218004028 cell division protein FtsW; Region: ftsW; TIGR02614 443218004029 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 443218004030 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443218004031 active site 443218004032 homodimer interface [polypeptide binding]; other site 443218004033 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443218004034 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218004035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218004036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218004037 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443218004038 Cell division protein FtsQ; Region: FtsQ; pfam03799 443218004039 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 443218004040 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443218004041 nucleotide binding site [chemical binding]; other site 443218004042 SulA interaction site; other site 443218004043 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443218004044 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 443218004045 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 443218004046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218004047 catalytic residue [active] 443218004048 Protein of unknown function (DUF552); Region: DUF552; cl00775 443218004049 YGGT family; Region: YGGT; cl00508 443218004050 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443218004051 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443218004052 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 443218004053 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443218004054 active site 443218004055 catalytic site [active] 443218004056 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443218004057 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443218004058 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443218004059 active site 443218004060 catalytic site [active] 443218004061 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443218004062 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443218004063 ligand binding site; other site 443218004064 oligomer interface; other site 443218004065 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443218004066 dimer interface [polypeptide binding]; other site 443218004067 N-terminal domain interface [polypeptide binding]; other site 443218004068 sulfate 1 binding site; other site 443218004069 phosphoglucomutase; Validated; Region: PRK07564 443218004070 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 443218004071 active site 443218004072 substrate binding site [chemical binding]; other site 443218004073 metal binding site [ion binding]; metal-binding site 443218004074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443218004075 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443218004076 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443218004077 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218004078 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443218004079 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443218004080 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443218004081 active site 443218004082 homodimer interface [polypeptide binding]; other site 443218004083 catalytic site [active] 443218004084 acceptor binding site [chemical binding]; other site 443218004085 glycogen branching enzyme; Provisional; Region: PRK05402 443218004086 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 443218004087 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443218004088 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443218004089 active site 443218004090 catalytic site [active] 443218004091 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443218004092 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 443218004093 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 443218004094 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218004095 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 443218004096 active site 443218004097 catalytic triad [active] 443218004098 dimer interface [polypeptide binding]; other site 443218004099 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218004100 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218004101 Erythromycin esterase; Region: Erythro_esteras; pfam05139 443218004102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218004103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004104 short chain dehydrogenase; Provisional; Region: PRK07825 443218004105 NAD(P) binding site [chemical binding]; other site 443218004106 active site 443218004107 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218004108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218004109 Patatin-like phospholipase; Region: Patatin; pfam01734 443218004110 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218004111 Predicted membrane protein [Function unknown]; Region: COG2311 443218004112 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218004113 Protein of unknown function (DUF418); Region: DUF418; pfam04235 443218004114 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 443218004115 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443218004116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218004117 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218004118 tetramerization interface [polypeptide binding]; other site 443218004119 NAD(P) binding site [chemical binding]; other site 443218004120 catalytic residues [active] 443218004121 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443218004122 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218004123 inhibitor-cofactor binding pocket; inhibition site 443218004124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004125 catalytic residue [active] 443218004126 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 443218004127 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 443218004128 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218004129 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218004130 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443218004131 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 443218004132 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443218004133 HIGH motif; other site 443218004134 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443218004135 active site 443218004136 KMSKS motif; other site 443218004137 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443218004138 tRNA binding surface [nucleotide binding]; other site 443218004139 anticodon binding site; other site 443218004140 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 443218004141 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 443218004142 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443218004143 active site 443218004144 Predicted permeases [General function prediction only]; Region: RarD; COG2962 443218004145 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 443218004146 agmatinase; Region: agmatinase; TIGR01230 443218004147 oligomer interface [polypeptide binding]; other site 443218004148 putative active site [active] 443218004149 Mn binding site [ion binding]; other site 443218004150 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218004151 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 443218004152 putative active site [active] 443218004153 catalytic triad [active] 443218004154 putative dimer interface [polypeptide binding]; other site 443218004155 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443218004156 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443218004157 active site 443218004158 PHP Thumb interface [polypeptide binding]; other site 443218004159 metal binding site [ion binding]; metal-binding site 443218004160 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443218004161 generic binding surface II; other site 443218004162 generic binding surface I; other site 443218004163 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 443218004164 reactive center loop; other site 443218004165 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443218004166 threonine dehydratase; Validated; Region: PRK08639 443218004167 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443218004168 tetramer interface [polypeptide binding]; other site 443218004169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004170 catalytic residue [active] 443218004171 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218004172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218004173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218004174 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443218004175 active site 443218004176 catalytic site [active] 443218004177 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443218004178 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443218004179 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 443218004180 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443218004181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218004182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218004183 DNA binding residues [nucleotide binding] 443218004184 SnoaL-like domain; Region: SnoaL_4; pfam13577 443218004185 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 443218004186 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218004187 inhibitor-cofactor binding pocket; inhibition site 443218004188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004189 catalytic residue [active] 443218004190 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 443218004191 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 443218004192 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218004193 catalytic residue [active] 443218004194 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443218004195 biotin synthase; Validated; Region: PRK06256 443218004196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218004197 FeS/SAM binding site; other site 443218004198 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443218004199 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443218004200 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443218004201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218004202 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218004203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218004204 DNA binding residues [nucleotide binding] 443218004205 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 443218004206 putative methyltransferase; Provisional; Region: PRK14967 443218004207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004208 S-adenosylmethionine binding site [chemical binding]; other site 443218004209 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 443218004210 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218004211 anti sigma factor interaction site; other site 443218004212 regulatory phosphorylation site [posttranslational modification]; other site 443218004213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443218004214 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443218004215 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443218004216 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 443218004217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443218004218 active site 443218004219 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218004220 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 443218004221 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218004222 iron-sulfur cluster [ion binding]; other site 443218004223 [2Fe-2S] cluster binding site [ion binding]; other site 443218004224 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443218004225 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 443218004226 putative ADP-binding pocket [chemical binding]; other site 443218004227 CsbD-like; Region: CsbD; pfam05532 443218004228 Cytochrome P450; Region: p450; cl12078 443218004229 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218004230 FAD binding domain; Region: FAD_binding_4; pfam01565 443218004231 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443218004232 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 443218004233 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218004234 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 443218004235 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218004236 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218004237 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218004238 anti sigma factor interaction site; other site 443218004239 regulatory phosphorylation site [posttranslational modification]; other site 443218004240 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218004241 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443218004242 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218004243 hydrophobic ligand binding site; other site 443218004244 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218004245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218004246 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 443218004247 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218004248 NAD binding site [chemical binding]; other site 443218004249 catalytic Zn binding site [ion binding]; other site 443218004250 structural Zn binding site [ion binding]; other site 443218004251 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443218004252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218004253 motif II; other site 443218004254 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 443218004255 putative hydrophobic ligand binding site [chemical binding]; other site 443218004256 hydroperoxidase II; Provisional; Region: katE; PRK11249 443218004257 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 443218004258 heme binding pocket [chemical binding]; other site 443218004259 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 443218004260 domain interactions; other site 443218004261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004262 short chain dehydrogenase; Provisional; Region: PRK06701 443218004263 NAD(P) binding site [chemical binding]; other site 443218004264 active site 443218004265 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 443218004266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218004267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218004268 DNA binding site [nucleotide binding] 443218004269 domain linker motif; other site 443218004270 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218004271 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443218004272 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443218004273 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443218004274 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443218004275 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218004276 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218004277 active site 443218004278 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218004279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004281 putative substrate translocation pore; other site 443218004282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218004284 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443218004285 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 443218004286 quinolinate synthetase; Provisional; Region: PRK09375 443218004287 L-aspartate oxidase; Provisional; Region: PRK07804 443218004288 L-aspartate oxidase; Provisional; Region: PRK06175 443218004289 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218004290 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443218004291 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 443218004292 dimerization interface [polypeptide binding]; other site 443218004293 active site 443218004294 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218004295 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443218004296 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443218004297 active site 443218004298 catalytic residues [active] 443218004299 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218004300 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 443218004301 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443218004302 NAD binding site [chemical binding]; other site 443218004303 dimerization interface [polypeptide binding]; other site 443218004304 product binding site; other site 443218004305 substrate binding site [chemical binding]; other site 443218004306 zinc binding site [ion binding]; other site 443218004307 catalytic residues [active] 443218004308 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443218004309 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218004310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004311 homodimer interface [polypeptide binding]; other site 443218004312 catalytic residue [active] 443218004313 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443218004314 putative active site pocket [active] 443218004315 4-fold oligomerization interface [polypeptide binding]; other site 443218004316 metal binding residues [ion binding]; metal-binding site 443218004317 3-fold/trimer interface [polypeptide binding]; other site 443218004318 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443218004319 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443218004320 putative active site [active] 443218004321 oxyanion strand; other site 443218004322 catalytic triad [active] 443218004323 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443218004324 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443218004325 catalytic residues [active] 443218004326 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443218004327 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 443218004328 active site 443218004329 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443218004330 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443218004331 substrate binding site [chemical binding]; other site 443218004332 glutamase interaction surface [polypeptide binding]; other site 443218004333 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443218004334 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 443218004335 Tautomerase enzyme; Region: Tautomerase; pfam01361 443218004336 active site 1 [active] 443218004337 dimer interface [polypeptide binding]; other site 443218004338 hexamer interface [polypeptide binding]; other site 443218004339 active site 2 [active] 443218004340 GYD domain; Region: GYD; cl01743 443218004341 Protein of unknown function (DUF998); Region: DUF998; pfam06197 443218004342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218004343 anthranilate synthase component I; Provisional; Region: PRK13571 443218004344 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443218004345 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443218004346 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 443218004347 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443218004348 active site 443218004349 ribulose/triose binding site [chemical binding]; other site 443218004350 phosphate binding site [ion binding]; other site 443218004351 substrate (anthranilate) binding pocket [chemical binding]; other site 443218004352 product (indole) binding pocket [chemical binding]; other site 443218004353 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443218004354 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443218004355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004356 catalytic residue [active] 443218004357 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443218004358 substrate binding site [chemical binding]; other site 443218004359 active site 443218004360 catalytic residues [active] 443218004361 heterodimer interface [polypeptide binding]; other site 443218004362 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 443218004363 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443218004364 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443218004365 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443218004366 active site 443218004367 dimer interface [polypeptide binding]; other site 443218004368 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443218004369 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218004370 active site 443218004371 FMN binding site [chemical binding]; other site 443218004372 substrate binding site [chemical binding]; other site 443218004373 3Fe-4S cluster binding site [ion binding]; other site 443218004374 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443218004375 domain interface; other site 443218004376 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443218004377 pyruvate kinase; Provisional; Region: PRK06247 443218004378 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443218004379 active site 443218004380 domain interfaces; other site 443218004381 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 443218004382 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 443218004383 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218004384 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443218004385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218004386 active site 443218004387 phosphorylation site [posttranslational modification] 443218004388 intermolecular recognition site; other site 443218004389 dimerization interface [polypeptide binding]; other site 443218004390 ANTAR domain; Region: ANTAR; pfam03861 443218004391 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443218004392 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443218004393 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443218004394 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443218004395 Walker A/P-loop; other site 443218004396 ATP binding site [chemical binding]; other site 443218004397 Q-loop/lid; other site 443218004398 ABC transporter signature motif; other site 443218004399 Walker B; other site 443218004400 D-loop; other site 443218004401 H-loop/switch region; other site 443218004402 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443218004403 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443218004404 Walker A/P-loop; other site 443218004405 ATP binding site [chemical binding]; other site 443218004406 Q-loop/lid; other site 443218004407 ABC transporter signature motif; other site 443218004408 Walker B; other site 443218004409 D-loop; other site 443218004410 H-loop/switch region; other site 443218004411 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443218004412 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218004413 TM-ABC transporter signature motif; other site 443218004414 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443218004415 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443218004416 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218004417 TM-ABC transporter signature motif; other site 443218004418 DNA polymerase I; Provisional; Region: PRK05755 443218004419 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443218004420 active site 443218004421 metal binding site 1 [ion binding]; metal-binding site 443218004422 putative 5' ssDNA interaction site; other site 443218004423 metal binding site 3; metal-binding site 443218004424 metal binding site 2 [ion binding]; metal-binding site 443218004425 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443218004426 putative DNA binding site [nucleotide binding]; other site 443218004427 putative metal binding site [ion binding]; other site 443218004428 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443218004429 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443218004430 active site 443218004431 DNA binding site [nucleotide binding] 443218004432 catalytic site [active] 443218004433 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218004434 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218004435 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 443218004436 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443218004437 conserved cys residue [active] 443218004438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218004439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218004440 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443218004441 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 443218004442 tartrate dehydrogenase; Region: TTC; TIGR02089 443218004443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218004444 catalytic residues [active] 443218004445 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218004446 Serine hydrolase (FSH1); Region: FSH1; pfam03959 443218004447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004448 S-adenosylmethionine binding site [chemical binding]; other site 443218004449 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443218004450 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443218004451 RNA binding site [nucleotide binding]; other site 443218004452 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443218004453 RNA binding site [nucleotide binding]; other site 443218004454 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218004455 RNA binding site [nucleotide binding]; other site 443218004456 S1 RNA binding domain; Region: S1; pfam00575 443218004457 RNA binding site [nucleotide binding]; other site 443218004458 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 443218004459 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443218004460 CoA-binding site [chemical binding]; other site 443218004461 ATP-binding [chemical binding]; other site 443218004462 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 443218004463 Protein of unknown function (DUF402); Region: DUF402; cl00979 443218004464 excinuclease ABC subunit B; Provisional; Region: PRK05298 443218004465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218004466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218004467 nucleotide binding region [chemical binding]; other site 443218004468 ATP-binding site [chemical binding]; other site 443218004469 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443218004470 UvrB/uvrC motif; Region: UVR; pfam02151 443218004471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218004472 Ligand Binding Site [chemical binding]; other site 443218004473 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 443218004474 Part of AAA domain; Region: AAA_19; pfam13245 443218004475 PhoH-like protein; Region: PhoH; cl17668 443218004476 Family description; Region: UvrD_C_2; pfam13538 443218004477 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443218004478 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443218004479 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443218004480 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443218004481 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443218004482 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 443218004483 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443218004484 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443218004485 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443218004486 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 443218004487 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443218004488 23S rRNA binding site [nucleotide binding]; other site 443218004489 L21 binding site [polypeptide binding]; other site 443218004490 L13 binding site [polypeptide binding]; other site 443218004491 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218004492 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 443218004493 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443218004494 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443218004495 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443218004496 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443218004497 dimer interface [polypeptide binding]; other site 443218004498 motif 1; other site 443218004499 active site 443218004500 motif 2; other site 443218004501 motif 3; other site 443218004502 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443218004503 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443218004504 putative tRNA-binding site [nucleotide binding]; other site 443218004505 B3/4 domain; Region: B3_4; pfam03483 443218004506 tRNA synthetase B5 domain; Region: B5; pfam03484 443218004507 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443218004508 dimer interface [polypeptide binding]; other site 443218004509 motif 1; other site 443218004510 motif 3; other site 443218004511 motif 2; other site 443218004512 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443218004513 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 443218004514 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443218004515 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443218004516 heterotetramer interface [polypeptide binding]; other site 443218004517 active site pocket [active] 443218004518 cleavage site 443218004519 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443218004520 feedback inhibition sensing region; other site 443218004521 homohexameric interface [polypeptide binding]; other site 443218004522 nucleotide binding site [chemical binding]; other site 443218004523 N-acetyl-L-glutamate binding site [chemical binding]; other site 443218004524 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443218004525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218004526 inhibitor-cofactor binding pocket; inhibition site 443218004527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004528 catalytic residue [active] 443218004529 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443218004530 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443218004531 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443218004532 arginine repressor; Provisional; Region: PRK03341 443218004533 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 443218004534 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 443218004535 argininosuccinate synthase; Provisional; Region: PRK13820 443218004536 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443218004537 ANP binding site [chemical binding]; other site 443218004538 Substrate Binding Site II [chemical binding]; other site 443218004539 Substrate Binding Site I [chemical binding]; other site 443218004540 argininosuccinate lyase; Provisional; Region: PRK00855 443218004541 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443218004542 active sites [active] 443218004543 tetramer interface [polypeptide binding]; other site 443218004544 acyl-CoA synthetase; Validated; Region: PRK07868 443218004545 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218004546 acyl-activating enzyme (AAE) consensus motif; other site 443218004547 AMP binding site [chemical binding]; other site 443218004548 active site 443218004549 CoA binding site [chemical binding]; other site 443218004550 Uncharacterized conserved protein [Function unknown]; Region: COG2835 443218004551 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443218004552 active site 443218004553 DNA binding site [nucleotide binding] 443218004554 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443218004555 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443218004556 active site 443218004557 HIGH motif; other site 443218004558 dimer interface [polypeptide binding]; other site 443218004559 KMSKS motif; other site 443218004560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218004561 RNA binding surface [nucleotide binding]; other site 443218004562 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443218004563 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 443218004564 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443218004565 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443218004566 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 443218004567 RNA binding surface [nucleotide binding]; other site 443218004568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004569 S-adenosylmethionine binding site [chemical binding]; other site 443218004570 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 443218004571 ATP-NAD kinase; Region: NAD_kinase; pfam01513 443218004572 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 443218004573 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443218004574 Walker A/P-loop; other site 443218004575 ATP binding site [chemical binding]; other site 443218004576 Q-loop/lid; other site 443218004577 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443218004578 ABC transporter signature motif; other site 443218004579 Walker B; other site 443218004580 D-loop; other site 443218004581 H-loop/switch region; other site 443218004582 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 443218004583 Thiamine pyrophosphokinase; Region: TPK; cl08415 443218004584 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 443218004585 CTP synthetase; Validated; Region: pyrG; PRK05380 443218004586 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443218004587 Catalytic site [active] 443218004588 active site 443218004589 UTP binding site [chemical binding]; other site 443218004590 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443218004591 active site 443218004592 putative oxyanion hole; other site 443218004593 catalytic triad [active] 443218004594 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443218004595 dimer interface [polypeptide binding]; other site 443218004596 ADP-ribose binding site [chemical binding]; other site 443218004597 active site 443218004598 nudix motif; other site 443218004599 metal binding site [ion binding]; metal-binding site 443218004600 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443218004601 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218004602 active site 443218004603 DNA binding site [nucleotide binding] 443218004604 Int/Topo IB signature motif; other site 443218004605 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218004606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218004607 P-loop; other site 443218004608 Magnesium ion binding site [ion binding]; other site 443218004609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218004610 Magnesium ion binding site [ion binding]; other site 443218004611 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 443218004612 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 443218004613 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443218004614 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218004615 RNA binding surface [nucleotide binding]; other site 443218004616 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443218004617 active site 443218004618 cytidylate kinase; Provisional; Region: cmk; PRK00023 443218004619 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443218004620 CMP-binding site; other site 443218004621 The sites determining sugar specificity; other site 443218004622 GTP-binding protein Der; Reviewed; Region: PRK03003 443218004623 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443218004624 G1 box; other site 443218004625 GTP/Mg2+ binding site [chemical binding]; other site 443218004626 Switch I region; other site 443218004627 G2 box; other site 443218004628 Switch II region; other site 443218004629 G3 box; other site 443218004630 G4 box; other site 443218004631 G5 box; other site 443218004632 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443218004633 G1 box; other site 443218004634 GTP/Mg2+ binding site [chemical binding]; other site 443218004635 Switch I region; other site 443218004636 G2 box; other site 443218004637 G3 box; other site 443218004638 Switch II region; other site 443218004639 G4 box; other site 443218004640 G5 box; other site 443218004641 Predicted membrane protein [Function unknown]; Region: COG2323 443218004642 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218004643 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 443218004644 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 443218004645 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218004646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218004648 PAS fold; Region: PAS_3; pfam08447 443218004649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218004650 putative active site [active] 443218004651 heme pocket [chemical binding]; other site 443218004652 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443218004653 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 443218004654 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218004655 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 443218004656 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218004657 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218004658 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218004659 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218004660 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218004661 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218004662 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 443218004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004664 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443218004665 putative substrate translocation pore; other site 443218004666 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443218004667 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 443218004668 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218004669 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 443218004670 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443218004671 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443218004672 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443218004673 PII uridylyl-transferase; Provisional; Region: PRK03381 443218004674 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218004675 metal binding triad; other site 443218004676 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218004677 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 443218004678 signal recognition particle protein; Provisional; Region: PRK10867 443218004679 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443218004680 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443218004681 P loop; other site 443218004682 GTP binding site [chemical binding]; other site 443218004683 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443218004684 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443218004685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218004686 active site 443218004687 CAAX protease self-immunity; Region: Abi; pfam02517 443218004688 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 443218004689 hypothetical protein; Provisional; Region: PRK02821 443218004690 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 443218004691 G-X-X-G motif; other site 443218004692 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443218004693 RimM N-terminal domain; Region: RimM; pfam01782 443218004694 PRC-barrel domain; Region: PRC; pfam05239 443218004695 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443218004696 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 443218004697 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 443218004698 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 443218004699 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218004700 RNA binding site [nucleotide binding]; other site 443218004701 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443218004702 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443218004703 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443218004704 Catalytic site [active] 443218004705 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443218004706 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443218004707 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218004708 active site 443218004709 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443218004710 hypothetical protein; Reviewed; Region: PRK12497 443218004711 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443218004712 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443218004713 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443218004714 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443218004715 DNA protecting protein DprA; Region: dprA; TIGR00732 443218004716 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 443218004717 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443218004718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218004719 active site 443218004720 DNA binding site [nucleotide binding] 443218004721 Int/Topo IB signature motif; other site 443218004722 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443218004723 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218004724 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443218004725 rRNA interaction site [nucleotide binding]; other site 443218004726 S8 interaction site; other site 443218004727 elongation factor Ts; Provisional; Region: tsf; PRK09377 443218004728 UBA/TS-N domain; Region: UBA; pfam00627 443218004729 Elongation factor TS; Region: EF_TS; pfam00889 443218004730 Elongation factor TS; Region: EF_TS; pfam00889 443218004731 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443218004732 putative nucleotide binding site [chemical binding]; other site 443218004733 uridine monophosphate binding site [chemical binding]; other site 443218004734 homohexameric interface [polypeptide binding]; other site 443218004735 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443218004736 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443218004737 hinge region; other site 443218004738 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443218004739 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443218004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443218004741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004742 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218004743 S-adenosylmethionine binding site [chemical binding]; other site 443218004744 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 443218004745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218004746 FeS/SAM binding site; other site 443218004747 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 443218004748 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443218004749 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443218004750 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443218004751 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443218004752 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443218004753 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443218004754 active site 443218004755 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218004756 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 443218004757 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443218004758 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443218004759 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443218004760 Predicted acetyltransferase [General function prediction only]; Region: COG3393 443218004761 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 443218004762 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443218004763 methionine aminopeptidase; Provisional; Region: PRK12318 443218004764 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218004765 active site 443218004766 cobyric acid synthase; Provisional; Region: PRK00784 443218004767 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218004768 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443218004769 catalytic triad [active] 443218004770 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218004771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218004772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218004773 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218004774 FAD binding domain; Region: FAD_binding_4; pfam01565 443218004775 diacylglycerol kinase; Reviewed; Region: PRK11914 443218004776 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443218004777 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218004778 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218004779 Walker A/P-loop; other site 443218004780 ATP binding site [chemical binding]; other site 443218004781 Q-loop/lid; other site 443218004782 ABC transporter signature motif; other site 443218004783 Walker B; other site 443218004784 D-loop; other site 443218004785 H-loop/switch region; other site 443218004786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218004787 DNA-binding site [nucleotide binding]; DNA binding site 443218004788 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 443218004789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443218004790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218004791 DNA-binding site [nucleotide binding]; DNA binding site 443218004792 FCD domain; Region: FCD; cl11656 443218004793 mycothione reductase; Reviewed; Region: PRK07846 443218004794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218004795 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218004796 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218004797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218004798 malate:quinone oxidoreductase; Validated; Region: PRK05257 443218004799 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 443218004800 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 443218004801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218004802 Walker A motif; other site 443218004803 ATP binding site [chemical binding]; other site 443218004804 Walker B motif; other site 443218004805 arginine finger; other site 443218004806 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 443218004807 metal ion-dependent adhesion site (MIDAS); other site 443218004808 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443218004809 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443218004810 Walker A motif; other site 443218004811 homodimer interface [polypeptide binding]; other site 443218004812 ATP binding site [chemical binding]; other site 443218004813 hydroxycobalamin binding site [chemical binding]; other site 443218004814 Walker B motif; other site 443218004815 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443218004816 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218004817 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218004818 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443218004819 catalytic triad [active] 443218004820 siroheme synthase; Provisional; Region: cysG; PRK10637 443218004821 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 443218004822 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443218004823 active site 443218004824 SAM binding site [chemical binding]; other site 443218004825 homodimer interface [polypeptide binding]; other site 443218004826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004827 putative substrate translocation pore; other site 443218004828 hypothetical protein; Validated; Region: PRK02101 443218004829 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443218004830 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443218004831 motif 1; other site 443218004832 dimer interface [polypeptide binding]; other site 443218004833 active site 443218004834 motif 2; other site 443218004835 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 443218004836 putative deacylase active site [active] 443218004837 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443218004838 active site 443218004839 motif 3; other site 443218004840 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443218004841 anticodon binding site; other site 443218004842 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443218004843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004844 S-adenosylmethionine binding site [chemical binding]; other site 443218004845 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443218004846 dinuclear metal binding motif [ion binding]; other site 443218004847 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443218004848 Sm and related proteins; Region: Sm_like; cl00259 443218004849 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443218004850 putative oligomer interface [polypeptide binding]; other site 443218004851 putative RNA binding site [nucleotide binding]; other site 443218004852 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443218004853 NusA N-terminal domain; Region: NusA_N; pfam08529 443218004854 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443218004855 RNA binding site [nucleotide binding]; other site 443218004856 homodimer interface [polypeptide binding]; other site 443218004857 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443218004858 G-X-X-G motif; other site 443218004859 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443218004860 G-X-X-G motif; other site 443218004861 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 443218004862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218004863 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443218004864 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 443218004865 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443218004866 G1 box; other site 443218004867 putative GEF interaction site [polypeptide binding]; other site 443218004868 GTP/Mg2+ binding site [chemical binding]; other site 443218004869 Switch I region; other site 443218004870 G2 box; other site 443218004871 G3 box; other site 443218004872 Switch II region; other site 443218004873 G4 box; other site 443218004874 G5 box; other site 443218004875 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443218004876 Translation-initiation factor 2; Region: IF-2; pfam11987 443218004877 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443218004878 Protein of unknown function (DUF503); Region: DUF503; pfam04456 443218004879 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 443218004880 DHH family; Region: DHH; pfam01368 443218004881 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443218004882 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 443218004883 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443218004884 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443218004885 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218004886 active site 443218004887 metal binding site [ion binding]; metal-binding site 443218004888 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443218004889 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443218004890 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443218004891 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443218004892 RNA binding site [nucleotide binding]; other site 443218004893 active site 443218004894 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443218004895 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443218004896 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443218004897 non-specific DNA interactions [nucleotide binding]; other site 443218004898 DNA binding site [nucleotide binding] 443218004899 sequence specific DNA binding site [nucleotide binding]; other site 443218004900 putative cAMP binding site [chemical binding]; other site 443218004901 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443218004902 FeoA domain; Region: FeoA; pfam04023 443218004903 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443218004904 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218004905 ABC-ATPase subunit interface; other site 443218004906 dimer interface [polypeptide binding]; other site 443218004907 putative PBP binding regions; other site 443218004908 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218004909 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443218004910 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 443218004911 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218004912 metal binding site [ion binding]; metal-binding site 443218004913 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443218004914 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443218004915 active site 443218004916 Riboflavin kinase; Region: Flavokinase; pfam01687 443218004917 LabA_like proteins; Region: LabA_like; cd06167 443218004918 putative metal binding site [ion binding]; other site 443218004919 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443218004920 16S/18S rRNA binding site [nucleotide binding]; other site 443218004921 S13e-L30e interaction site [polypeptide binding]; other site 443218004922 25S rRNA binding site [nucleotide binding]; other site 443218004923 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443218004924 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443218004925 oligomer interface [polypeptide binding]; other site 443218004926 RNA binding site [nucleotide binding]; other site 443218004927 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443218004928 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443218004929 RNase E interface [polypeptide binding]; other site 443218004930 trimer interface [polypeptide binding]; other site 443218004931 active site 443218004932 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443218004933 putative nucleic acid binding region [nucleotide binding]; other site 443218004934 G-X-X-G motif; other site 443218004935 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443218004936 RNA binding site [nucleotide binding]; other site 443218004937 domain interface; other site 443218004938 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443218004939 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443218004940 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443218004941 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443218004942 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443218004943 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443218004944 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443218004945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218004946 HicB family; Region: HicB; pfam05534 443218004947 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443218004948 putative hydrophobic ligand binding site [chemical binding]; other site 443218004949 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443218004950 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443218004951 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443218004952 dimer interface [polypeptide binding]; other site 443218004953 active site 443218004954 catalytic residue [active] 443218004955 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443218004956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218004957 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443218004958 Putative sensor; Region: Sensor; pfam13796 443218004959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218004960 Histidine kinase; Region: HisKA_3; pfam07730 443218004961 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218004962 ATP binding site [chemical binding]; other site 443218004963 Mg2+ binding site [ion binding]; other site 443218004964 G-X-G motif; other site 443218004965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218004967 active site 443218004968 phosphorylation site [posttranslational modification] 443218004969 intermolecular recognition site; other site 443218004970 dimerization interface [polypeptide binding]; other site 443218004971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218004972 DNA binding residues [nucleotide binding] 443218004973 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218004974 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218004975 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 443218004976 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443218004977 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443218004978 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443218004979 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218004980 rod shape-determining protein MreB; Provisional; Region: PRK13930 443218004981 MreB and similar proteins; Region: MreB_like; cd10225 443218004982 nucleotide binding site [chemical binding]; other site 443218004983 Mg binding site [ion binding]; other site 443218004984 putative protofilament interaction site [polypeptide binding]; other site 443218004985 RodZ interaction site [polypeptide binding]; other site 443218004986 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218004987 NlpC/P60 family; Region: NLPC_P60; pfam00877 443218004988 Cupin domain; Region: Cupin_2; cl17218 443218004989 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218004990 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218004991 putative active site [active] 443218004992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218004993 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 443218004994 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443218004995 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443218004996 Proline dehydrogenase; Region: Pro_dh; cl03282 443218004997 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218004998 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218004999 NAD(P) binding site [chemical binding]; other site 443218005000 catalytic residues [active] 443218005001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218005002 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 443218005003 putative dimerization interface [polypeptide binding]; other site 443218005004 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443218005005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218005006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218005007 catalytic residue [active] 443218005008 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 443218005009 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 443218005010 5' nucleotidase family; Region: 5_nucleotid; cl17687 443218005011 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 443218005012 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 443218005013 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 443218005014 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218005015 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443218005016 active site 443218005017 catalytic site [active] 443218005018 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443218005019 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218005020 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218005021 Walker A/P-loop; other site 443218005022 ATP binding site [chemical binding]; other site 443218005023 Q-loop/lid; other site 443218005024 ABC transporter signature motif; other site 443218005025 Walker B; other site 443218005026 D-loop; other site 443218005027 H-loop/switch region; other site 443218005028 TOBE domain; Region: TOBE_2; pfam08402 443218005029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218005030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005031 dimer interface [polypeptide binding]; other site 443218005032 conserved gate region; other site 443218005033 putative PBP binding loops; other site 443218005034 ABC-ATPase subunit interface; other site 443218005035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005036 dimer interface [polypeptide binding]; other site 443218005037 conserved gate region; other site 443218005038 putative PBP binding loops; other site 443218005039 ABC-ATPase subunit interface; other site 443218005040 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218005041 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218005042 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218005043 active site 443218005044 catalytic site [active] 443218005045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218005046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218005047 DNA binding site [nucleotide binding] 443218005048 domain linker motif; other site 443218005049 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218005050 dimerization interface [polypeptide binding]; other site 443218005051 ligand binding site [chemical binding]; other site 443218005052 short chain dehydrogenase; Provisional; Region: PRK07814 443218005053 classical (c) SDRs; Region: SDR_c; cd05233 443218005054 NAD(P) binding site [chemical binding]; other site 443218005055 active site 443218005056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218005057 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218005058 active site 443218005059 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443218005060 Phosphotransferase enzyme family; Region: APH; pfam01636 443218005061 putative active site [active] 443218005062 putative substrate binding site [chemical binding]; other site 443218005063 ATP binding site [chemical binding]; other site 443218005064 Helix-turn-helix domain; Region: HTH_19; pfam12844 443218005065 sequence-specific DNA binding site [nucleotide binding]; other site 443218005066 salt bridge; other site 443218005067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218005069 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218005070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218005071 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 443218005072 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443218005073 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 443218005074 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443218005075 YCII-related domain; Region: YCII; cl00999 443218005076 YCII-related domain; Region: YCII; cl00999 443218005077 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218005078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218005079 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218005080 YCII-related domain; Region: YCII; cl00999 443218005081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218005082 Coenzyme A binding pocket [chemical binding]; other site 443218005083 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218005084 Competence-damaged protein; Region: CinA; pfam02464 443218005085 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443218005086 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443218005087 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218005088 homodimer interface [polypeptide binding]; other site 443218005089 active site 443218005090 TDP-binding site; other site 443218005091 acceptor substrate-binding pocket; other site 443218005092 Epoxide hydrolase N terminus; Region: EHN; pfam06441 443218005093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218005094 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 443218005095 recombinase A; Provisional; Region: recA; PRK09354 443218005096 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443218005097 hexamer interface [polypeptide binding]; other site 443218005098 Walker A motif; other site 443218005099 ATP binding site [chemical binding]; other site 443218005100 Walker B motif; other site 443218005101 recombination regulator RecX; Reviewed; Region: recX; PRK00117 443218005102 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 443218005103 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 443218005104 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 443218005105 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 443218005106 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 443218005107 Domain of unknown function (DUF897); Region: DUF897; cl01312 443218005108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218005109 dimerization interface [polypeptide binding]; other site 443218005110 putative Zn2+ binding site [ion binding]; other site 443218005111 putative DNA binding site [nucleotide binding]; other site 443218005112 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443218005113 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443218005114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218005115 FeS/SAM binding site; other site 443218005116 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218005117 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218005118 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218005119 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 443218005120 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443218005121 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443218005122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218005123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218005124 DNA binding site [nucleotide binding] 443218005125 domain linker motif; other site 443218005126 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 443218005127 putative dimerization interface [polypeptide binding]; other site 443218005128 putative ligand binding site [chemical binding]; other site 443218005129 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218005130 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218005131 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443218005132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005133 dimer interface [polypeptide binding]; other site 443218005134 conserved gate region; other site 443218005135 putative PBP binding loops; other site 443218005136 ABC-ATPase subunit interface; other site 443218005137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005139 dimer interface [polypeptide binding]; other site 443218005140 conserved gate region; other site 443218005141 putative PBP binding loops; other site 443218005142 ABC-ATPase subunit interface; other site 443218005143 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443218005144 active site 443218005145 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218005146 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218005147 Walker A/P-loop; other site 443218005148 ATP binding site [chemical binding]; other site 443218005149 Q-loop/lid; other site 443218005150 ABC transporter signature motif; other site 443218005151 Walker B; other site 443218005152 D-loop; other site 443218005153 H-loop/switch region; other site 443218005154 TOBE domain; Region: TOBE; pfam03459 443218005155 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218005156 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218005157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218005158 Transporter associated domain; Region: CorC_HlyC; pfam03471 443218005159 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218005160 FOG: CBS domain [General function prediction only]; Region: COG0517 443218005161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218005162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218005164 NAD(P) binding site [chemical binding]; other site 443218005165 active site 443218005166 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 443218005167 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443218005168 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443218005169 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 443218005170 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443218005171 HflX GTPase family; Region: HflX; cd01878 443218005172 G1 box; other site 443218005173 GTP/Mg2+ binding site [chemical binding]; other site 443218005174 Switch I region; other site 443218005175 G2 box; other site 443218005176 G3 box; other site 443218005177 Switch II region; other site 443218005178 G4 box; other site 443218005179 G5 box; other site 443218005180 LexA repressor; Validated; Region: PRK00215 443218005181 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443218005182 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443218005183 Catalytic site [active] 443218005184 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443218005185 ATP cone domain; Region: ATP-cone; pfam03477 443218005186 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 443218005187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005188 ATP binding site [chemical binding]; other site 443218005189 putative Mg++ binding site [ion binding]; other site 443218005190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005191 nucleotide binding region [chemical binding]; other site 443218005192 ATP-binding site [chemical binding]; other site 443218005193 Helicase associated domain (HA2); Region: HA2; pfam04408 443218005194 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 443218005195 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 443218005196 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 443218005197 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 443218005198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005199 NAD(P) binding site [chemical binding]; other site 443218005200 active site 443218005201 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218005202 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 443218005203 dimer interface [polypeptide binding]; other site 443218005204 active site 443218005205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218005206 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218005207 active site 443218005208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005209 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 443218005210 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218005211 active site 443218005212 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443218005213 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443218005214 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443218005215 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 443218005216 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218005217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005218 ATP binding site [chemical binding]; other site 443218005219 putative Mg++ binding site [ion binding]; other site 443218005220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005221 nucleotide binding region [chemical binding]; other site 443218005222 ATP-binding site [chemical binding]; other site 443218005223 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 443218005224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218005225 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443218005226 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443218005227 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443218005228 PAC2 family; Region: PAC2; pfam09754 443218005229 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 443218005230 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 443218005231 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 443218005232 NAD binding site [chemical binding]; other site 443218005233 homodimer interface [polypeptide binding]; other site 443218005234 active site 443218005235 substrate binding site [chemical binding]; other site 443218005236 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443218005237 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 443218005238 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443218005239 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443218005240 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 443218005241 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 443218005242 active site 443218005243 Zn binding site [ion binding]; other site 443218005244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218005245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218005246 Coenzyme A binding pocket [chemical binding]; other site 443218005247 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 443218005248 CoA binding domain; Region: CoA_binding_2; pfam13380 443218005249 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 443218005250 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 443218005251 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443218005252 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443218005253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218005254 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218005255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218005256 DNA binding residues [nucleotide binding] 443218005257 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443218005258 putative active site [active] 443218005259 dimerization interface [polypeptide binding]; other site 443218005260 putative tRNAtyr binding site [nucleotide binding]; other site 443218005261 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 443218005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218005263 S-adenosylmethionine binding site [chemical binding]; other site 443218005264 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443218005265 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 443218005266 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 443218005267 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443218005268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005269 ATP binding site [chemical binding]; other site 443218005270 putative Mg++ binding site [ion binding]; other site 443218005271 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443218005272 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443218005273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218005274 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218005275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218005276 DNA binding residues [nucleotide binding] 443218005277 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218005278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443218005279 nucleotide binding site [chemical binding]; other site 443218005280 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443218005281 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443218005282 active site 443218005283 dimerization interface [polypeptide binding]; other site 443218005284 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218005285 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 443218005286 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 443218005287 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443218005288 trimer interface [polypeptide binding]; other site 443218005289 active site 443218005290 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443218005291 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443218005292 TRAM domain; Region: TRAM; pfam01938 443218005293 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443218005294 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443218005295 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443218005296 TPP-binding site; other site 443218005297 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218005298 PYR/PP interface [polypeptide binding]; other site 443218005299 dimer interface [polypeptide binding]; other site 443218005300 TPP binding site [chemical binding]; other site 443218005301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218005302 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443218005303 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443218005304 catalytic site [active] 443218005305 putative active site [active] 443218005306 putative substrate binding site [chemical binding]; other site 443218005307 HRDC domain; Region: HRDC; cl02578 443218005308 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443218005309 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443218005310 substrate binding site [chemical binding]; other site 443218005311 active site 443218005312 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443218005313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218005314 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 443218005315 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 443218005316 SelR domain; Region: SelR; pfam01641 443218005317 Domain of unknown function (DUF389); Region: DUF389; pfam04087 443218005318 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443218005319 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218005320 hypothetical protein; Provisional; Region: PRK14059 443218005321 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443218005322 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443218005323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005324 Walker A motif; other site 443218005325 ATP binding site [chemical binding]; other site 443218005326 Walker B motif; other site 443218005327 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218005328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218005329 Coenzyme A binding pocket [chemical binding]; other site 443218005330 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 443218005331 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443218005332 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443218005333 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443218005334 active site 443218005335 dimer interface [polypeptide binding]; other site 443218005336 motif 1; other site 443218005337 motif 2; other site 443218005338 motif 3; other site 443218005339 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443218005340 anticodon binding site; other site 443218005341 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443218005342 nucleotide binding site/active site [active] 443218005343 HIT family signature motif; other site 443218005344 catalytic residue [active] 443218005345 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443218005346 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443218005347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443218005348 putative acyl-acceptor binding pocket; other site 443218005349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218005350 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218005351 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 443218005352 nudix motif; other site 443218005353 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443218005354 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443218005355 active site 443218005356 multimer interface [polypeptide binding]; other site 443218005357 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443218005358 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443218005359 active site 443218005360 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443218005361 catalytic triad [active] 443218005362 dimer interface [polypeptide binding]; other site 443218005363 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443218005364 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 443218005365 predicted active site [active] 443218005366 catalytic triad [active] 443218005367 hypothetical protein; Validated; Region: PRK00110 443218005368 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443218005369 active site 443218005370 putative DNA-binding cleft [nucleotide binding]; other site 443218005371 dimer interface [polypeptide binding]; other site 443218005372 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443218005373 RuvA N terminal domain; Region: RuvA_N; pfam01330 443218005374 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443218005375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005376 Walker A motif; other site 443218005377 ATP binding site [chemical binding]; other site 443218005378 Walker B motif; other site 443218005379 arginine finger; other site 443218005380 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443218005381 Preprotein translocase subunit; Region: YajC; cl00806 443218005382 protein-export membrane protein SecD; Region: secD; TIGR01129 443218005383 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443218005384 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443218005385 Protein export membrane protein; Region: SecD_SecF; pfam02355 443218005386 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443218005387 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443218005388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218005389 active site 443218005390 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 443218005391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443218005392 Zn2+ binding site [ion binding]; other site 443218005393 Mg2+ binding site [ion binding]; other site 443218005394 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443218005395 synthetase active site [active] 443218005396 NTP binding site [chemical binding]; other site 443218005397 metal binding site [ion binding]; metal-binding site 443218005398 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443218005399 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443218005400 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443218005401 active site 443218005402 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443218005403 active site 443218005404 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443218005405 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443218005406 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443218005407 dimer interface [polypeptide binding]; other site 443218005408 motif 1; other site 443218005409 active site 443218005410 motif 2; other site 443218005411 motif 3; other site 443218005412 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443218005413 anticodon binding site; other site 443218005414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218005415 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443218005416 FeS/SAM binding site; other site 443218005417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218005418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218005419 putative substrate translocation pore; other site 443218005420 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443218005421 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 443218005422 putative DNA binding site [nucleotide binding]; other site 443218005423 catalytic residue [active] 443218005424 putative H2TH interface [polypeptide binding]; other site 443218005425 putative catalytic residues [active] 443218005426 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218005427 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218005428 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443218005429 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443218005430 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443218005431 dimer interface [polypeptide binding]; other site 443218005432 anticodon binding site; other site 443218005433 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443218005434 homodimer interface [polypeptide binding]; other site 443218005435 motif 1; other site 443218005436 active site 443218005437 motif 2; other site 443218005438 GAD domain; Region: GAD; pfam02938 443218005439 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443218005440 active site 443218005441 motif 3; other site 443218005442 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 443218005443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443218005444 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443218005445 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443218005446 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443218005447 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443218005448 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443218005449 substrate binding site [chemical binding]; other site 443218005450 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218005451 Sulfatase; Region: Sulfatase; cl17466 443218005452 PhoD-like phosphatase; Region: PhoD; pfam09423 443218005453 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218005454 putative active site [active] 443218005455 putative metal binding site [ion binding]; other site 443218005456 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218005457 recombination factor protein RarA; Reviewed; Region: PRK13342 443218005458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005459 Walker A motif; other site 443218005460 ATP binding site [chemical binding]; other site 443218005461 Walker B motif; other site 443218005462 arginine finger; other site 443218005463 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443218005464 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443218005465 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443218005466 motif 1; other site 443218005467 active site 443218005468 motif 2; other site 443218005469 motif 3; other site 443218005470 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443218005471 DHHA1 domain; Region: DHHA1; pfam02272 443218005472 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 443218005473 YceG-like family; Region: YceG; pfam02618 443218005474 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 443218005475 dimerization interface [polypeptide binding]; other site 443218005476 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 443218005477 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443218005478 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443218005479 shikimate binding site; other site 443218005480 NAD(P) binding site [chemical binding]; other site 443218005481 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443218005482 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443218005483 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443218005484 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443218005485 Tetramer interface [polypeptide binding]; other site 443218005486 active site 443218005487 FMN-binding site [chemical binding]; other site 443218005488 shikimate kinase; Reviewed; Region: aroK; PRK00131 443218005489 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443218005490 ADP binding site [chemical binding]; other site 443218005491 magnesium binding site [ion binding]; other site 443218005492 putative shikimate binding site; other site 443218005493 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443218005494 active site 443218005495 dimer interface [polypeptide binding]; other site 443218005496 metal binding site [ion binding]; metal-binding site 443218005497 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218005498 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218005499 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443218005500 active site 443218005501 elongation factor P; Validated; Region: PRK00529 443218005502 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443218005503 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443218005504 RNA binding site [nucleotide binding]; other site 443218005505 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443218005506 RNA binding site [nucleotide binding]; other site 443218005507 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 443218005508 putative RNA binding site [nucleotide binding]; other site 443218005509 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443218005510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218005511 active site 443218005512 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443218005513 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443218005514 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443218005515 dihydroorotase; Validated; Region: pyrC; PRK09357 443218005516 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443218005517 active site 443218005518 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443218005519 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443218005520 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443218005521 catalytic site [active] 443218005522 subunit interface [polypeptide binding]; other site 443218005523 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443218005524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218005525 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218005526 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443218005527 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218005528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218005529 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443218005530 IMP binding site; other site 443218005531 dimer interface [polypeptide binding]; other site 443218005532 interdomain contacts; other site 443218005533 partial ornithine binding site; other site 443218005534 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443218005535 active site 443218005536 dimer interface [polypeptide binding]; other site 443218005537 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443218005538 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443218005539 catalytic site [active] 443218005540 G-X2-G-X-G-K; other site 443218005541 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 443218005542 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443218005543 Flavoprotein; Region: Flavoprotein; pfam02441 443218005544 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443218005545 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443218005546 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443218005547 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443218005548 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443218005549 primosome assembly protein PriA; Provisional; Region: PRK14873 443218005550 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218005551 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443218005552 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218005553 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218005554 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005555 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218005556 Lipase (class 2); Region: Lipase_2; pfam01674 443218005557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005558 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443218005559 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443218005560 putative active site [active] 443218005561 substrate binding site [chemical binding]; other site 443218005562 putative cosubstrate binding site; other site 443218005563 catalytic site [active] 443218005564 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443218005565 substrate binding site [chemical binding]; other site 443218005566 16S rRNA methyltransferase B; Provisional; Region: PRK14902 443218005567 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 443218005568 putative RNA binding site [nucleotide binding]; other site 443218005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218005570 S-adenosylmethionine binding site [chemical binding]; other site 443218005571 amidase; Provisional; Region: PRK07869 443218005572 Amidase; Region: Amidase; cl11426 443218005573 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 443218005574 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443218005575 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 443218005576 substrate binding site [chemical binding]; other site 443218005577 hexamer interface [polypeptide binding]; other site 443218005578 metal binding site [ion binding]; metal-binding site 443218005579 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443218005580 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443218005581 catalytic motif [active] 443218005582 Zn binding site [ion binding]; other site 443218005583 RibD C-terminal domain; Region: RibD_C; pfam01872 443218005584 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443218005585 Lumazine binding domain; Region: Lum_binding; pfam00677 443218005586 Lumazine binding domain; Region: Lum_binding; pfam00677 443218005587 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443218005588 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443218005589 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443218005590 dimerization interface [polypeptide binding]; other site 443218005591 active site 443218005592 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443218005593 homopentamer interface [polypeptide binding]; other site 443218005594 active site 443218005595 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443218005596 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443218005597 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443218005598 GIY-YIG motif/motif A; other site 443218005599 active site 443218005600 catalytic site [active] 443218005601 putative DNA binding site [nucleotide binding]; other site 443218005602 metal binding site [ion binding]; metal-binding site 443218005603 UvrB/uvrC motif; Region: UVR; pfam02151 443218005604 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443218005605 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 443218005606 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 443218005607 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 443218005608 phosphate binding site [ion binding]; other site 443218005609 putative substrate binding pocket [chemical binding]; other site 443218005610 dimer interface [polypeptide binding]; other site 443218005611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443218005612 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443218005613 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443218005614 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 443218005615 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443218005616 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443218005617 Phosphoglycerate kinase; Region: PGK; pfam00162 443218005618 substrate binding site [chemical binding]; other site 443218005619 hinge regions; other site 443218005620 ADP binding site [chemical binding]; other site 443218005621 catalytic site [active] 443218005622 triosephosphate isomerase; Provisional; Region: PRK14567 443218005623 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443218005624 substrate binding site [chemical binding]; other site 443218005625 dimer interface [polypeptide binding]; other site 443218005626 catalytic triad [active] 443218005627 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 443218005628 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 443218005629 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443218005630 putative active site [active] 443218005631 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443218005632 putative active site [active] 443218005633 transaldolase; Provisional; Region: PRK03903 443218005634 catalytic residue [active] 443218005635 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443218005636 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218005637 TPP-binding site [chemical binding]; other site 443218005638 dimer interface [polypeptide binding]; other site 443218005639 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218005640 PYR/PP interface [polypeptide binding]; other site 443218005641 dimer interface [polypeptide binding]; other site 443218005642 TPP binding site [chemical binding]; other site 443218005643 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218005644 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 443218005645 UbiA prenyltransferase family; Region: UbiA; pfam01040 443218005646 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443218005647 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443218005648 NADP binding site [chemical binding]; other site 443218005649 dimer interface [polypeptide binding]; other site 443218005650 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 443218005651 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 443218005652 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218005653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218005654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218005655 Walker A/P-loop; other site 443218005656 ATP binding site [chemical binding]; other site 443218005657 Q-loop/lid; other site 443218005658 ABC transporter signature motif; other site 443218005659 Walker B; other site 443218005660 D-loop; other site 443218005661 H-loop/switch region; other site 443218005662 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443218005663 Predicted transcriptional regulator [Transcription]; Region: COG2345 443218005664 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443218005665 FeS assembly protein SufB; Region: sufB; TIGR01980 443218005666 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 443218005667 FeS assembly protein SufD; Region: sufD; TIGR01981 443218005668 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 443218005669 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 443218005670 Walker A/P-loop; other site 443218005671 ATP binding site [chemical binding]; other site 443218005672 Q-loop/lid; other site 443218005673 ABC transporter signature motif; other site 443218005674 Walker B; other site 443218005675 D-loop; other site 443218005676 H-loop/switch region; other site 443218005677 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218005678 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443218005679 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218005680 catalytic residue [active] 443218005681 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443218005682 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443218005683 trimerization site [polypeptide binding]; other site 443218005684 active site 443218005685 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 443218005686 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 443218005687 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443218005688 lycopene cyclase; Region: lycopene_cycl; TIGR01789 443218005689 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 443218005690 classical (c) SDRs; Region: SDR_c; cd05233 443218005691 NAD(P) binding site [chemical binding]; other site 443218005692 active site 443218005693 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218005694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218005695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218005696 Walker A/P-loop; other site 443218005697 ATP binding site [chemical binding]; other site 443218005698 Q-loop/lid; other site 443218005699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218005700 ABC transporter signature motif; other site 443218005701 Walker B; other site 443218005702 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218005703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218005705 aconitate hydratase; Validated; Region: PRK09277 443218005706 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443218005707 substrate binding site [chemical binding]; other site 443218005708 ligand binding site [chemical binding]; other site 443218005709 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443218005710 substrate binding site [chemical binding]; other site 443218005711 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218005712 NlpC/P60 family; Region: NLPC_P60; pfam00877 443218005713 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218005714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005715 Walker A motif; other site 443218005716 ATP binding site [chemical binding]; other site 443218005717 Walker B motif; other site 443218005718 arginine finger; other site 443218005719 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218005720 Protein of unknown function DUF58; Region: DUF58; pfam01882 443218005721 hypothetical protein; Provisional; Region: PRK13685 443218005722 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 443218005723 von Willebrand factor type A domain; Region: VWA_2; pfam13519 443218005724 metal ion-dependent adhesion site (MIDAS); other site 443218005725 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443218005726 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443218005727 NAD(P) binding site [chemical binding]; other site 443218005728 homotetramer interface [polypeptide binding]; other site 443218005729 homodimer interface [polypeptide binding]; other site 443218005730 active site 443218005731 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 443218005732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005733 NAD(P) binding site [chemical binding]; other site 443218005734 active site 443218005735 ferrochelatase; Reviewed; Region: hemH; PRK00035 443218005736 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443218005737 C-terminal domain interface [polypeptide binding]; other site 443218005738 active site 443218005739 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443218005740 active site 443218005741 N-terminal domain interface [polypeptide binding]; other site 443218005742 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443218005743 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 443218005744 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443218005745 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443218005746 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218005747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218005748 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443218005749 DNA-binding interface [nucleotide binding]; DNA binding site 443218005750 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443218005751 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443218005752 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 443218005753 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 443218005754 heterodimer interface [polypeptide binding]; other site 443218005755 substrate interaction site [chemical binding]; other site 443218005756 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443218005757 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 443218005758 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 443218005759 active site 443218005760 substrate binding site [chemical binding]; other site 443218005761 coenzyme B12 binding site [chemical binding]; other site 443218005762 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443218005763 B12 binding site [chemical binding]; other site 443218005764 cobalt ligand [ion binding]; other site 443218005765 membrane ATPase/protein kinase; Provisional; Region: PRK09435 443218005766 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 443218005767 GTP/Mg2+ binding site [chemical binding]; other site 443218005768 G5 box; other site 443218005769 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443218005770 Walker A; other site 443218005771 G1 box; other site 443218005772 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218005773 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443218005774 Walker A/P-loop; other site 443218005775 ATP binding site [chemical binding]; other site 443218005776 Q-loop/lid; other site 443218005777 ABC transporter signature motif; other site 443218005778 Walker B; other site 443218005779 D-loop; other site 443218005780 H-loop/switch region; other site 443218005781 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218005782 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443218005783 Walker A/P-loop; other site 443218005784 ATP binding site [chemical binding]; other site 443218005785 Q-loop/lid; other site 443218005786 ABC transporter signature motif; other site 443218005787 Walker B; other site 443218005788 D-loop; other site 443218005789 H-loop/switch region; other site 443218005790 Cobalt transport protein; Region: CbiQ; cl00463 443218005791 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 443218005792 active site 443218005793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218005795 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218005796 dimer interface [polypeptide binding]; other site 443218005797 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218005798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218005799 active site 443218005800 ATP binding site [chemical binding]; other site 443218005801 substrate binding site [chemical binding]; other site 443218005802 activation loop (A-loop); other site 443218005803 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443218005804 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443218005805 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218005806 phosphopeptide binding site; other site 443218005807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218005808 DNA binding residues [nucleotide binding] 443218005809 dimerization interface [polypeptide binding]; other site 443218005810 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 443218005811 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218005812 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218005813 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443218005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005815 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443218005816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005817 active site 443218005818 hypothetical protein; Provisional; Region: PRK07906 443218005819 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443218005820 putative metal binding site [ion binding]; other site 443218005821 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443218005822 substrate binding site [chemical binding]; other site 443218005823 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 443218005824 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443218005825 quinone interaction residues [chemical binding]; other site 443218005826 active site 443218005827 catalytic residues [active] 443218005828 FMN binding site [chemical binding]; other site 443218005829 substrate binding site [chemical binding]; other site 443218005830 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443218005831 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 443218005832 heme binding pocket [chemical binding]; other site 443218005833 heme ligand [chemical binding]; other site 443218005834 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 443218005835 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218005836 catalytic core [active] 443218005837 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 443218005838 conserved hypothetical protein; Region: TIGR03843 443218005839 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218005840 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443218005841 active site 443218005842 HIGH motif; other site 443218005843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218005844 active site 443218005845 KMSKS motif; other site 443218005846 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 443218005847 putative tRNA binding surface [nucleotide binding]; other site 443218005848 PAC2 family; Region: PAC2; pfam09754 443218005849 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 443218005850 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 443218005851 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 443218005852 substrate binding pocket [chemical binding]; other site 443218005853 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 443218005854 B12 binding site [chemical binding]; other site 443218005855 cobalt ligand [ion binding]; other site 443218005856 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 443218005857 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443218005858 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443218005859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218005860 motif II; other site 443218005861 Protein of unknown function (DUF419); Region: DUF419; pfam04237 443218005862 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443218005863 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443218005864 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 443218005865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218005866 active site 443218005867 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 443218005868 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 443218005869 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218005870 Cupin domain; Region: Cupin_2; pfam07883 443218005871 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 443218005872 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443218005873 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 443218005874 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 443218005875 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218005876 [2Fe-2S] cluster binding site [ion binding]; other site 443218005877 iron-sulfur cluster [ion binding]; other site 443218005878 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 443218005879 nickel binding site [ion binding]; other site 443218005880 HupF/HypC family; Region: HupF_HypC; pfam01455 443218005881 Acylphosphatase; Region: Acylphosphatase; pfam00708 443218005882 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 443218005883 HypF finger; Region: zf-HYPF; pfam07503 443218005884 HypF finger; Region: zf-HYPF; pfam07503 443218005885 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 443218005886 HupF/HypC family; Region: HupF_HypC; pfam01455 443218005887 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 443218005888 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 443218005889 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 443218005890 dimerization interface [polypeptide binding]; other site 443218005891 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 443218005892 ATP binding site [chemical binding]; other site 443218005893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218005895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 443218005896 homodimer interface [polypeptide binding]; other site 443218005897 putative metal binding site [ion binding]; other site 443218005898 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443218005899 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443218005900 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443218005901 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218005902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218005903 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 443218005904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218005905 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218005906 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443218005907 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443218005908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218005909 S-adenosylmethionine binding site [chemical binding]; other site 443218005910 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 443218005911 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 443218005912 active site 443218005913 nucleophile elbow; other site 443218005914 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443218005915 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443218005916 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443218005917 active site 443218005918 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218005919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218005920 putative DNA binding site [nucleotide binding]; other site 443218005921 putative Zn2+ binding site [ion binding]; other site 443218005922 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443218005923 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443218005924 active site 443218005925 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443218005926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005927 ATP binding site [chemical binding]; other site 443218005928 putative Mg++ binding site [ion binding]; other site 443218005929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005930 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 443218005931 nucleotide binding region [chemical binding]; other site 443218005932 ATP-binding site [chemical binding]; other site 443218005933 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443218005934 active site 443218005935 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218005936 hydrophobic ligand binding site; other site 443218005937 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 443218005938 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443218005939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005940 ATP binding site [chemical binding]; other site 443218005941 putative Mg++ binding site [ion binding]; other site 443218005942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005943 nucleotide binding region [chemical binding]; other site 443218005944 ATP-binding site [chemical binding]; other site 443218005945 proteasome ATPase; Region: pup_AAA; TIGR03689 443218005946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005947 Walker A motif; other site 443218005948 ATP binding site [chemical binding]; other site 443218005949 Walker B motif; other site 443218005950 arginine finger; other site 443218005951 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 443218005952 Pup-like protein; Region: Pup; cl05289 443218005953 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 443218005954 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443218005955 active site 443218005956 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 443218005957 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443218005958 active site 443218005959 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443218005960 active site 443218005961 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 443218005962 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218005963 WYL domain; Region: WYL; pfam13280 443218005964 WYL domain; Region: WYL; pfam13280 443218005965 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 443218005966 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 443218005967 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443218005968 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218005969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005970 ATP binding site [chemical binding]; other site 443218005971 putative Mg++ binding site [ion binding]; other site 443218005972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005973 nucleotide binding region [chemical binding]; other site 443218005974 ATP-binding site [chemical binding]; other site 443218005975 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443218005976 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443218005977 aldehyde dehydrogenase family 7 member; Region: PLN02315 443218005978 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 443218005979 tetrameric interface [polypeptide binding]; other site 443218005980 NAD binding site [chemical binding]; other site 443218005981 catalytic residues [active] 443218005982 5'-3' exonuclease; Region: 53EXOc; smart00475 443218005983 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443218005984 active site 443218005985 metal binding site 1 [ion binding]; metal-binding site 443218005986 putative 5' ssDNA interaction site; other site 443218005987 metal binding site 3; metal-binding site 443218005988 metal binding site 2 [ion binding]; metal-binding site 443218005989 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443218005990 putative DNA binding site [nucleotide binding]; other site 443218005991 putative metal binding site [ion binding]; other site 443218005992 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218005993 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218005994 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 443218005995 active site 443218005996 Thioredoxin; Region: Thioredoxin_4; cl17273 443218005997 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443218005998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005999 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218006000 NAD(P) binding site [chemical binding]; other site 443218006001 active site 443218006002 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443218006003 active site 443218006004 putative homodimer interface [polypeptide binding]; other site 443218006005 SAM binding site [chemical binding]; other site 443218006006 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443218006007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218006008 S-adenosylmethionine binding site [chemical binding]; other site 443218006009 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443218006010 active site 443218006011 SAM binding site [chemical binding]; other site 443218006012 homodimer interface [polypeptide binding]; other site 443218006013 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 443218006014 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 443218006015 Uncharacterized conserved protein [Function unknown]; Region: COG1434 443218006016 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218006017 putative active site [active] 443218006018 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 443218006019 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443218006020 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 443218006021 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443218006022 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218006023 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443218006024 VPS10 domain; Region: VPS10; smart00602 443218006025 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443218006026 active site 443218006027 SAM binding site [chemical binding]; other site 443218006028 homodimer interface [polypeptide binding]; other site 443218006029 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443218006030 active site 443218006031 SAM binding site [chemical binding]; other site 443218006032 homodimer interface [polypeptide binding]; other site 443218006033 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 443218006034 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443218006035 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443218006036 putative homotetramer interface [polypeptide binding]; other site 443218006037 putative homodimer interface [polypeptide binding]; other site 443218006038 putative allosteric switch controlling residues; other site 443218006039 putative metal binding site [ion binding]; other site 443218006040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443218006041 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443218006042 metal-binding site [ion binding] 443218006043 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218006044 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443218006045 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443218006046 metal-binding site [ion binding] 443218006047 Domain of unknown function (DUF305); Region: DUF305; pfam03713 443218006048 precorrin-3B synthase; Region: CobG; TIGR02435 443218006049 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218006050 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218006051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218006052 acyl-activating enzyme (AAE) consensus motif; other site 443218006053 AMP binding site [chemical binding]; other site 443218006054 active site 443218006055 CoA binding site [chemical binding]; other site 443218006056 metabolite-proton symporter; Region: 2A0106; TIGR00883 443218006057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218006059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006060 DNA binding residues [nucleotide binding] 443218006061 dimerization interface [polypeptide binding]; other site 443218006062 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 443218006063 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443218006064 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443218006065 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 443218006066 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443218006067 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443218006068 shikimate binding site; other site 443218006069 NAD(P) binding site [chemical binding]; other site 443218006070 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218006071 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218006072 Walker A/P-loop; other site 443218006073 ATP binding site [chemical binding]; other site 443218006074 Q-loop/lid; other site 443218006075 ABC transporter signature motif; other site 443218006076 Walker B; other site 443218006077 D-loop; other site 443218006078 H-loop/switch region; other site 443218006079 TOBE domain; Region: TOBE_2; pfam08402 443218006080 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 443218006081 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006082 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218006083 catalytic site [active] 443218006084 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443218006085 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443218006086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218006087 Histidine kinase; Region: HisKA_3; pfam07730 443218006088 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218006089 ATP binding site [chemical binding]; other site 443218006090 Mg2+ binding site [ion binding]; other site 443218006091 G-X-G motif; other site 443218006092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218006093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006094 active site 443218006095 phosphorylation site [posttranslational modification] 443218006096 intermolecular recognition site; other site 443218006097 dimerization interface [polypeptide binding]; other site 443218006098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006099 dimerization interface [polypeptide binding]; other site 443218006100 DNA binding residues [nucleotide binding] 443218006101 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 443218006102 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443218006103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218006104 active site 443218006105 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 443218006106 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443218006107 putative active site [active] 443218006108 catalytic triad [active] 443218006109 putative dimer interface [polypeptide binding]; other site 443218006110 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443218006111 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443218006112 Ligand binding site; other site 443218006113 Putative Catalytic site; other site 443218006114 DXD motif; other site 443218006115 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 443218006116 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443218006117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218006118 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218006119 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 443218006120 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 443218006121 active site 443218006122 putative substrate binding pocket [chemical binding]; other site 443218006123 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006124 hydrophobic ligand binding site; other site 443218006125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006126 Peptidase family M48; Region: Peptidase_M48; cl12018 443218006127 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 443218006128 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 443218006129 alpha-gamma subunit interface [polypeptide binding]; other site 443218006130 beta-gamma subunit interface [polypeptide binding]; other site 443218006131 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 443218006132 gamma-beta subunit interface [polypeptide binding]; other site 443218006133 alpha-beta subunit interface [polypeptide binding]; other site 443218006134 urease subunit alpha; Reviewed; Region: ureC; PRK13206 443218006135 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 443218006136 subunit interactions [polypeptide binding]; other site 443218006137 active site 443218006138 flap region; other site 443218006139 UreF; Region: UreF; pfam01730 443218006140 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443218006141 UreD urease accessory protein; Region: UreD; cl00530 443218006142 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 443218006143 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443218006144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006145 dimer interface [polypeptide binding]; other site 443218006146 conserved gate region; other site 443218006147 putative PBP binding loops; other site 443218006148 ABC-ATPase subunit interface; other site 443218006149 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443218006150 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 443218006151 Walker A/P-loop; other site 443218006152 ATP binding site [chemical binding]; other site 443218006153 Q-loop/lid; other site 443218006154 ABC transporter signature motif; other site 443218006155 Walker B; other site 443218006156 D-loop; other site 443218006157 H-loop/switch region; other site 443218006158 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 443218006159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218006160 Uncharacterized conserved protein [Function unknown]; Region: COG1434 443218006161 putative active site [active] 443218006162 Predicted esterase [General function prediction only]; Region: COG0627 443218006163 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218006164 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443218006165 Walker A/P-loop; other site 443218006166 ATP binding site [chemical binding]; other site 443218006167 Q-loop/lid; other site 443218006168 ABC transporter signature motif; other site 443218006169 Walker B; other site 443218006170 D-loop; other site 443218006171 H-loop/switch region; other site 443218006172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006173 dimer interface [polypeptide binding]; other site 443218006174 conserved gate region; other site 443218006175 putative PBP binding loops; other site 443218006176 ABC-ATPase subunit interface; other site 443218006177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006178 dimer interface [polypeptide binding]; other site 443218006179 conserved gate region; other site 443218006180 putative PBP binding loops; other site 443218006181 ABC-ATPase subunit interface; other site 443218006182 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218006183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218006184 substrate binding pocket [chemical binding]; other site 443218006185 membrane-bound complex binding site; other site 443218006186 hinge residues; other site 443218006187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218006189 putative substrate translocation pore; other site 443218006190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218006191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218006192 active site 443218006193 ATP binding site [chemical binding]; other site 443218006194 substrate binding site [chemical binding]; other site 443218006195 activation loop (A-loop); other site 443218006196 Kelch domain; Region: Kelch; smart00612 443218006197 Kelch motif; Region: Kelch_1; pfam01344 443218006198 Galactose oxidase, central domain; Region: Kelch_3; cl02701 443218006199 Kelch domain; Region: Kelch; smart00612 443218006200 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 443218006201 Kelch motif; Region: Kelch_6; pfam13964 443218006202 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443218006203 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443218006204 [4Fe-4S] binding site [ion binding]; other site 443218006205 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006206 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006207 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006208 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443218006209 molybdopterin cofactor binding site; other site 443218006210 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443218006211 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443218006212 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 443218006213 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443218006214 short chain dehydrogenase; Provisional; Region: PRK08267 443218006215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006216 NAD(P) binding site [chemical binding]; other site 443218006217 active site 443218006218 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 443218006219 dimer interface [polypeptide binding]; other site 443218006220 putative tRNA-binding site [nucleotide binding]; other site 443218006221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218006222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443218006223 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 443218006224 nudix motif; other site 443218006225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218006226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006227 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218006228 Walker A/P-loop; other site 443218006229 ATP binding site [chemical binding]; other site 443218006230 Q-loop/lid; other site 443218006231 ABC transporter signature motif; other site 443218006232 Walker B; other site 443218006233 D-loop; other site 443218006234 H-loop/switch region; other site 443218006235 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218006236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006237 Walker A/P-loop; other site 443218006238 ATP binding site [chemical binding]; other site 443218006239 Q-loop/lid; other site 443218006240 ABC transporter signature motif; other site 443218006241 Walker B; other site 443218006242 D-loop; other site 443218006243 H-loop/switch region; other site 443218006244 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 443218006245 RNase_H superfamily; Region: RNase_H_2; pfam13482 443218006246 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 443218006247 AAA domain; Region: AAA_30; pfam13604 443218006248 AAA domain; Region: AAA_12; pfam13087 443218006249 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 443218006250 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 443218006251 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 443218006252 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443218006253 putative active site [active] 443218006254 putative dimer interface [polypeptide binding]; other site 443218006255 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 443218006256 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443218006257 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218006258 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218006259 minor groove reading motif; other site 443218006260 helix-hairpin-helix signature motif; other site 443218006261 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218006262 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218006263 Di-iron ligands [ion binding]; other site 443218006264 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 443218006265 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 443218006266 putative NAD(P) binding site [chemical binding]; other site 443218006267 putative substrate binding site [chemical binding]; other site 443218006268 catalytic Zn binding site [ion binding]; other site 443218006269 structural Zn binding site [ion binding]; other site 443218006270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443218006272 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443218006273 GAF domain; Region: GAF_3; pfam13492 443218006274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218006275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006276 ATP binding site [chemical binding]; other site 443218006277 Mg2+ binding site [ion binding]; other site 443218006278 G-X-G motif; other site 443218006279 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443218006280 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443218006281 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443218006282 phosphoenolpyruvate synthase; Validated; Region: PRK06464 443218006283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443218006284 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 443218006285 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443218006286 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218006287 dimer interface [polypeptide binding]; other site 443218006288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443218006289 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218006290 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218006291 Di-iron ligands [ion binding]; other site 443218006292 PRC-barrel domain; Region: PRC; pfam05239 443218006293 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 443218006294 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443218006295 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443218006296 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443218006297 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443218006298 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006299 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218006300 catalytic site [active] 443218006301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218006302 Ligand Binding Site [chemical binding]; other site 443218006303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218006304 Ligand Binding Site [chemical binding]; other site 443218006305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218006307 active site 443218006308 metal binding site [ion binding]; metal-binding site 443218006309 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218006310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006311 substrate binding site [chemical binding]; other site 443218006312 oxyanion hole (OAH) forming residues; other site 443218006313 trimer interface [polypeptide binding]; other site 443218006314 HSP90 family protein; Provisional; Region: PRK14083 443218006315 Predicted acetyltransferase [General function prediction only]; Region: COG3153 443218006316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218006318 putative substrate translocation pore; other site 443218006319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218006320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218006321 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 443218006322 putative dimerization interface [polypeptide binding]; other site 443218006323 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443218006324 active site 443218006325 metal binding site [ion binding]; metal-binding site 443218006326 nudix motif; other site 443218006327 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 443218006328 active site 443218006329 Peptidase family M50; Region: Peptidase_M50; pfam02163 443218006330 putative substrate binding region [chemical binding]; other site 443218006331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443218006332 oxidoreductase; Provisional; Region: PRK12743 443218006333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006334 NAD(P) binding site [chemical binding]; other site 443218006335 active site 443218006336 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218006337 active site 443218006338 nucleophile elbow; other site 443218006339 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443218006340 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443218006341 hypothetical protein; Provisional; Region: PRK10621 443218006342 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 443218006343 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218006344 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443218006345 PAS domain; Region: PAS_9; pfam13426 443218006346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443218006347 putative active site [active] 443218006348 heme pocket [chemical binding]; other site 443218006349 ANTAR domain; Region: ANTAR; pfam03861 443218006350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443218006351 FAD binding domain; Region: FAD_binding_4; pfam01565 443218006352 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443218006353 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443218006354 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 443218006355 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218006356 ring oligomerisation interface [polypeptide binding]; other site 443218006357 ATP/Mg binding site [chemical binding]; other site 443218006358 stacking interactions; other site 443218006359 hinge regions; other site 443218006360 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443218006361 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 443218006362 NAD binding site [chemical binding]; other site 443218006363 substrate binding site [chemical binding]; other site 443218006364 catalytic Zn binding site [ion binding]; other site 443218006365 structural Zn binding site [ion binding]; other site 443218006366 Domain of unknown function DUF59; Region: DUF59; pfam01883 443218006367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 443218006368 active site 443218006369 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 443218006370 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 443218006371 dimerization interface [polypeptide binding]; other site 443218006372 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 443218006373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006374 catalytic loop [active] 443218006375 iron binding site [ion binding]; other site 443218006376 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 443218006377 FAD binding pocket [chemical binding]; other site 443218006378 FAD binding motif [chemical binding]; other site 443218006379 phosphate binding motif [ion binding]; other site 443218006380 beta-alpha-beta structure motif; other site 443218006381 NAD binding pocket [chemical binding]; other site 443218006382 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 443218006383 dimerization interface [polypeptide binding]; other site 443218006384 putative path to active site cavity [active] 443218006385 diiron center [ion binding]; other site 443218006386 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 443218006387 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443218006388 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443218006389 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218006390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218006391 putative DNA binding site [nucleotide binding]; other site 443218006392 putative Zn2+ binding site [ion binding]; other site 443218006393 AsnC family; Region: AsnC_trans_reg; pfam01037 443218006394 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 443218006395 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218006396 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218006397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218006398 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443218006399 MarR family; Region: MarR_2; cl17246 443218006400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218006401 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443218006402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006404 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 443218006405 putative hydrophobic ligand binding site [chemical binding]; other site 443218006406 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443218006407 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218006408 homodimer interface [polypeptide binding]; other site 443218006409 active site 443218006410 TDP-binding site; other site 443218006411 acceptor substrate-binding pocket; other site 443218006412 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443218006413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218006415 DNA binding residues [nucleotide binding] 443218006416 SnoaL-like domain; Region: SnoaL_2; pfam12680 443218006417 RibD C-terminal domain; Region: RibD_C; cl17279 443218006418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218006419 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 443218006420 putative NAD(P) binding site [chemical binding]; other site 443218006421 Lipase maturation factor; Region: LMF1; pfam06762 443218006422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218006425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006427 WHG domain; Region: WHG; pfam13305 443218006428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006430 SCP-2 sterol transfer family; Region: SCP2; pfam02036 443218006431 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443218006432 active site 1 [active] 443218006433 dimer interface [polypeptide binding]; other site 443218006434 hexamer interface [polypeptide binding]; other site 443218006435 active site 2 [active] 443218006436 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443218006437 SCP-2 sterol transfer family; Region: SCP2; pfam02036 443218006438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006439 H-loop/switch region; other site 443218006440 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218006441 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 443218006442 acyl-activating enzyme (AAE) consensus motif; other site 443218006443 putative AMP binding site [chemical binding]; other site 443218006444 putative active site [active] 443218006445 putative CoA binding site [chemical binding]; other site 443218006446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218006447 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 443218006448 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218006449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218006450 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218006451 Transcriptional regulator PadR-like family; Region: PadR; cl17335 443218006452 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218006453 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218006454 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006455 substrate binding site [chemical binding]; other site 443218006456 oxyanion hole (OAH) forming residues; other site 443218006457 trimer interface [polypeptide binding]; other site 443218006458 enoyl-CoA hydratase; Provisional; Region: PRK06563 443218006459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006460 substrate binding site [chemical binding]; other site 443218006461 oxyanion hole (OAH) forming residues; other site 443218006462 trimer interface [polypeptide binding]; other site 443218006463 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 443218006464 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218006465 dimer interface [polypeptide binding]; other site 443218006466 active site 443218006467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006469 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443218006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006473 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218006474 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443218006475 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443218006476 active site 443218006477 FMN binding site [chemical binding]; other site 443218006478 2,4-decadienoyl-CoA binding site; other site 443218006479 catalytic residue [active] 443218006480 4Fe-4S cluster binding site [ion binding]; other site 443218006481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218006482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218006483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006484 active site 443218006485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006486 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218006487 catalytic site [active] 443218006488 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218006489 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218006490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006492 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006493 short chain dehydrogenase; Provisional; Region: PRK08267 443218006494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006495 NAD(P) binding site [chemical binding]; other site 443218006496 active site 443218006497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006501 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218006502 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443218006503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006504 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218006506 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218006507 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218006508 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443218006509 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218006510 NAD(P) binding site [chemical binding]; other site 443218006511 catalytic residues [active] 443218006512 short chain dehydrogenase; Provisional; Region: PRK07825 443218006513 classical (c) SDRs; Region: SDR_c; cd05233 443218006514 NAD(P) binding site [chemical binding]; other site 443218006515 active site 443218006516 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218006517 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218006518 acyl-activating enzyme (AAE) consensus motif; other site 443218006519 putative AMP binding site [chemical binding]; other site 443218006520 putative active site [active] 443218006521 putative CoA binding site [chemical binding]; other site 443218006522 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006523 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006524 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 443218006525 active site 443218006526 catalytic residues [active] 443218006527 L-arabinose isomerase; Provisional; Region: PRK02929 443218006528 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 443218006529 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443218006530 trimer interface [polypeptide binding]; other site 443218006531 substrate binding site [chemical binding]; other site 443218006532 Mn binding site [ion binding]; other site 443218006533 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 443218006534 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 443218006535 intersubunit interface [polypeptide binding]; other site 443218006536 active site 443218006537 Zn2+ binding site [ion binding]; other site 443218006538 ribulokinase; Provisional; Region: PRK04123 443218006539 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 443218006540 N- and C-terminal domain interface [polypeptide binding]; other site 443218006541 active site 443218006542 MgATP binding site [chemical binding]; other site 443218006543 catalytic site [active] 443218006544 metal binding site [ion binding]; metal-binding site 443218006545 carbohydrate binding site [chemical binding]; other site 443218006546 homodimer interface [polypeptide binding]; other site 443218006547 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218006548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218006549 DNA binding site [nucleotide binding] 443218006550 domain linker motif; other site 443218006551 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443218006552 ligand binding site [chemical binding]; other site 443218006553 dimerization interface (open form) [polypeptide binding]; other site 443218006554 dimerization interface (closed form) [polypeptide binding]; other site 443218006555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218006556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443218006557 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 443218006558 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218006559 putative active site [active] 443218006560 catalytic triad [active] 443218006561 putative dimer interface [polypeptide binding]; other site 443218006562 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 443218006563 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 443218006564 ligand binding site [chemical binding]; other site 443218006565 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443218006566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443218006567 TM-ABC transporter signature motif; other site 443218006568 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 443218006569 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443218006570 Walker A/P-loop; other site 443218006571 ATP binding site [chemical binding]; other site 443218006572 Q-loop/lid; other site 443218006573 ABC transporter signature motif; other site 443218006574 Walker B; other site 443218006575 D-loop; other site 443218006576 H-loop/switch region; other site 443218006577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443218006578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218006579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218006580 active site 443218006581 catalytic tetrad [active] 443218006582 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218006583 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218006584 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 443218006585 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 443218006586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218006587 motif II; other site 443218006588 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443218006589 homotrimer interaction site [polypeptide binding]; other site 443218006590 putative active site [active] 443218006591 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443218006592 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443218006593 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218006594 catalytic residue [active] 443218006595 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218006596 classical (c) SDRs; Region: SDR_c; cd05233 443218006597 NAD(P) binding site [chemical binding]; other site 443218006598 active site 443218006599 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 443218006600 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218006601 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218006602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218006603 DNA-binding site [nucleotide binding]; DNA binding site 443218006604 FCD domain; Region: FCD; pfam07729 443218006605 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 443218006606 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443218006607 putative active site [active] 443218006608 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218006609 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 443218006610 HD domain; Region: HD_4; pfam13328 443218006611 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443218006612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218006613 Cytochrome P450; Region: p450; cl12078 443218006614 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006615 hydrophobic ligand binding site; other site 443218006616 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006617 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218006618 FMN-binding pocket [chemical binding]; other site 443218006619 flavin binding motif; other site 443218006620 phosphate binding motif [ion binding]; other site 443218006621 beta-alpha-beta structure motif; other site 443218006622 NAD binding pocket [chemical binding]; other site 443218006623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006624 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218006625 catalytic loop [active] 443218006626 iron binding site [ion binding]; other site 443218006627 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006628 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006629 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443218006630 short chain dehydrogenase; Provisional; Region: PRK07825 443218006631 classical (c) SDRs; Region: SDR_c; cd05233 443218006632 NAD(P) binding site [chemical binding]; other site 443218006633 active site 443218006634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218006637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218006638 active site 443218006639 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218006640 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218006641 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218006642 acyl-activating enzyme (AAE) consensus motif; other site 443218006643 acyl-activating enzyme (AAE) consensus motif; other site 443218006644 putative AMP binding site [chemical binding]; other site 443218006645 putative active site [active] 443218006646 putative CoA binding site [chemical binding]; other site 443218006647 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 443218006648 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 443218006649 NAD(P) binding site [chemical binding]; other site 443218006650 catalytic residues [active] 443218006651 short chain dehydrogenase; Provisional; Region: PRK08278 443218006652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006653 NAD(P) binding site [chemical binding]; other site 443218006654 active site 443218006655 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218006656 CoenzymeA binding site [chemical binding]; other site 443218006657 subunit interaction site [polypeptide binding]; other site 443218006658 PHB binding site; other site 443218006659 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218006660 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218006661 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218006662 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 443218006663 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 443218006664 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443218006665 putative active site [active] 443218006666 putative FMN binding site [chemical binding]; other site 443218006667 putative substrate binding site [chemical binding]; other site 443218006668 putative catalytic residue [active] 443218006669 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 443218006670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218006671 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218006672 classical (c) SDRs; Region: SDR_c; cd05233 443218006673 NAD(P) binding site [chemical binding]; other site 443218006674 active site 443218006675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218006677 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218006678 putative NAD(P) binding site [chemical binding]; other site 443218006679 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218006680 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218006681 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006682 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218006683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218006684 S-adenosylmethionine binding site [chemical binding]; other site 443218006685 RibD C-terminal domain; Region: RibD_C; cl17279 443218006686 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443218006687 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443218006688 conserved cys residue [active] 443218006689 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 443218006690 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443218006691 conserved cys residue [active] 443218006692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006693 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 443218006694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218006695 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218006696 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 443218006697 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 443218006698 putative ligand binding residues [chemical binding]; other site 443218006699 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443218006700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218006701 ABC-ATPase subunit interface; other site 443218006702 dimer interface [polypeptide binding]; other site 443218006703 putative PBP binding regions; other site 443218006704 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 443218006705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218006706 Walker A/P-loop; other site 443218006707 ATP binding site [chemical binding]; other site 443218006708 Q-loop/lid; other site 443218006709 ABC transporter signature motif; other site 443218006710 Walker B; other site 443218006711 D-loop; other site 443218006712 H-loop/switch region; other site 443218006713 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218006715 Coenzyme A binding pocket [chemical binding]; other site 443218006716 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 443218006717 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218006718 NAD binding site [chemical binding]; other site 443218006719 substrate binding site [chemical binding]; other site 443218006720 putative active site [active] 443218006721 Cupin; Region: Cupin_6; pfam12852 443218006722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006724 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218006725 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218006726 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218006727 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218006728 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006729 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218006730 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 443218006731 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 443218006732 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 443218006733 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 443218006734 ligand binding site [chemical binding]; other site 443218006735 homodimer interface [polypeptide binding]; other site 443218006736 NAD(P) binding site [chemical binding]; other site 443218006737 trimer interface B [polypeptide binding]; other site 443218006738 trimer interface A [polypeptide binding]; other site 443218006739 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 443218006740 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218006741 putative active site [active] 443218006742 RibD C-terminal domain; Region: RibD_C; cl17279 443218006743 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443218006744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006746 ATP binding site [chemical binding]; other site 443218006747 Mg2+ binding site [ion binding]; other site 443218006748 G-X-G motif; other site 443218006749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218006750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006751 active site 443218006752 phosphorylation site [posttranslational modification] 443218006753 intermolecular recognition site; other site 443218006754 dimerization interface [polypeptide binding]; other site 443218006755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006756 DNA binding residues [nucleotide binding] 443218006757 dimerization interface [polypeptide binding]; other site 443218006758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006760 ABC transporter signature motif; other site 443218006761 ABC transporter signature motif; other site 443218006762 Walker B; other site 443218006763 Walker B; other site 443218006764 D-loop; other site 443218006765 D-loop; other site 443218006766 H-loop/switch region; other site 443218006767 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 443218006768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443218006769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218006770 Coenzyme A binding pocket [chemical binding]; other site 443218006771 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 443218006772 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 443218006773 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218006774 DNA binding residues [nucleotide binding] 443218006775 putative dimer interface [polypeptide binding]; other site 443218006776 HEAT repeats; Region: HEAT_2; pfam13646 443218006777 hypothetical protein; Provisional; Region: PRK06834 443218006778 TrkA-N domain; Region: TrkA_N; pfam02254 443218006779 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218006780 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 443218006781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218006785 putative substrate translocation pore; other site 443218006786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006787 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006789 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006790 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006791 hydrophobic ligand binding site; other site 443218006792 hypothetical protein; Validated; Region: PRK07198 443218006793 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 443218006794 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443218006795 dimerization interface [polypeptide binding]; other site 443218006796 active site 443218006797 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 443218006798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218006799 active site 443218006800 Amino acid permease; Region: AA_permease_2; pfam13520 443218006801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218006802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006803 DNA binding residues [nucleotide binding] 443218006804 dimerization interface [polypeptide binding]; other site 443218006805 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443218006806 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443218006807 NAD binding site [chemical binding]; other site 443218006808 catalytic Zn binding site [ion binding]; other site 443218006809 substrate binding site [chemical binding]; other site 443218006810 structural Zn binding site [ion binding]; other site 443218006811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218006812 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443218006813 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443218006814 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218006815 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443218006816 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443218006817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218006819 DNA binding residues [nucleotide binding] 443218006820 SnoaL-like domain; Region: SnoaL_2; pfam12680 443218006821 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006822 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218006824 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218006825 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218006826 active site 443218006827 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 443218006828 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443218006829 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443218006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006831 Walker A/P-loop; other site 443218006832 ATP binding site [chemical binding]; other site 443218006833 Q-loop/lid; other site 443218006834 AAA domain; Region: AAA_21; pfam13304 443218006835 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443218006836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006837 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443218006838 Walker A/P-loop; other site 443218006839 ATP binding site [chemical binding]; other site 443218006840 Q-loop/lid; other site 443218006841 ABC transporter signature motif; other site 443218006842 Walker B; other site 443218006843 D-loop; other site 443218006844 H-loop/switch region; other site 443218006845 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218006846 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006850 YCII-related domain; Region: YCII; cl00999 443218006851 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218006852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006853 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218006854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218006855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006856 active site 443218006857 phosphorylation site [posttranslational modification] 443218006858 intermolecular recognition site; other site 443218006859 dimerization interface [polypeptide binding]; other site 443218006860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218006861 DNA binding site [nucleotide binding] 443218006862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218006863 dimerization interface [polypeptide binding]; other site 443218006864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218006865 dimer interface [polypeptide binding]; other site 443218006866 phosphorylation site [posttranslational modification] 443218006867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006868 ATP binding site [chemical binding]; other site 443218006869 Mg2+ binding site [ion binding]; other site 443218006870 G-X-G motif; other site 443218006871 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 443218006872 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218006873 DNA binding residues [nucleotide binding] 443218006874 TOBE domain; Region: TOBE; cl01440 443218006875 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443218006876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443218006877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006878 dimer interface [polypeptide binding]; other site 443218006879 conserved gate region; other site 443218006880 putative PBP binding loops; other site 443218006881 ABC-ATPase subunit interface; other site 443218006882 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218006883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218006884 Walker A/P-loop; other site 443218006885 ATP binding site [chemical binding]; other site 443218006886 Q-loop/lid; other site 443218006887 ABC transporter signature motif; other site 443218006888 Walker B; other site 443218006889 D-loop; other site 443218006890 H-loop/switch region; other site 443218006891 TOBE domain; Region: TOBE; cl01440 443218006892 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 443218006893 Amidohydrolase; Region: Amidohydro_2; pfam04909 443218006894 YaeQ protein; Region: YaeQ; cl01913 443218006895 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 443218006896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218006897 membrane-bound complex binding site; other site 443218006898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218006899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218006900 dimer interface [polypeptide binding]; other site 443218006901 phosphorylation site [posttranslational modification] 443218006902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006903 Mg2+ binding site [ion binding]; other site 443218006904 G-X-G motif; other site 443218006905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218006906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006907 active site 443218006908 dimerization interface [polypeptide binding]; other site 443218006909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218006910 DNA binding site [nucleotide binding] 443218006911 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443218006912 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443218006913 transmembrane helices; other site 443218006914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218006915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218006916 active site 443218006917 SnoaL-like domain; Region: SnoaL_2; pfam12680 443218006918 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218006919 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443218006920 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218006921 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218006922 metal binding site 2 [ion binding]; metal-binding site 443218006923 putative DNA binding helix; other site 443218006924 metal binding site 1 [ion binding]; metal-binding site 443218006925 dimer interface [polypeptide binding]; other site 443218006926 structural Zn2+ binding site [ion binding]; other site 443218006927 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443218006928 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443218006929 dimer interface [polypeptide binding]; other site 443218006930 active site 443218006931 heme binding site [chemical binding]; other site 443218006932 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443218006933 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 443218006934 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 443218006935 Protein of unknown function (DUF429); Region: DUF429; cl12046 443218006936 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218006937 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006938 molybdopterin cofactor binding site; other site 443218006939 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006940 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218006941 putative molybdopterin cofactor binding site; other site 443218006942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006943 trimer interface [polypeptide binding]; other site 443218006944 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 443218006945 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218006946 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218006947 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 443218006948 putative hydrophobic ligand binding site [chemical binding]; other site 443218006949 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006950 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006951 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218006952 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218006953 acyl-activating enzyme (AAE) consensus motif; other site 443218006954 putative AMP binding site [chemical binding]; other site 443218006955 putative active site [active] 443218006956 putative CoA binding site [chemical binding]; other site 443218006957 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218006958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218006959 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218006960 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443218006961 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218006962 NAD(P) binding site [chemical binding]; other site 443218006963 catalytic residues [active] 443218006964 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218006965 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218006966 putative acyl-acceptor binding pocket; other site 443218006967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218006969 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006970 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006971 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218006972 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218006973 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443218006974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006975 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218006976 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218006977 Cytochrome P450; Region: p450; cl12078 443218006978 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006979 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218006980 FMN-binding pocket [chemical binding]; other site 443218006981 flavin binding motif; other site 443218006982 phosphate binding motif [ion binding]; other site 443218006983 beta-alpha-beta structure motif; other site 443218006984 NAD binding pocket [chemical binding]; other site 443218006985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006986 catalytic loop [active] 443218006987 iron binding site [ion binding]; other site 443218006988 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218006989 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218006990 iron-sulfur cluster [ion binding]; other site 443218006991 [2Fe-2S] cluster binding site [ion binding]; other site 443218006992 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218006993 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218006994 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006995 FAD binding pocket [chemical binding]; other site 443218006996 FAD binding motif [chemical binding]; other site 443218006997 phosphate binding motif [ion binding]; other site 443218006998 beta-alpha-beta structure motif; other site 443218006999 NAD binding pocket [chemical binding]; other site 443218007000 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007001 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218007002 catalytic loop [active] 443218007003 iron binding site [ion binding]; other site 443218007004 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218007005 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218007006 putative di-iron ligands [ion binding]; other site 443218007007 Protein of unknown function (DUF419); Region: DUF419; cl15265 443218007008 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218007009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007011 DNA binding residues [nucleotide binding] 443218007012 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443218007013 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218007014 DNA binding site [nucleotide binding] 443218007015 active site 443218007016 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 443218007017 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 443218007018 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 443218007019 MOSC domain; Region: MOSC; pfam03473 443218007020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218007021 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443218007022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218007023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443218007024 Walker A/P-loop; other site 443218007025 ATP binding site [chemical binding]; other site 443218007026 Q-loop/lid; other site 443218007027 ABC transporter signature motif; other site 443218007028 Walker B; other site 443218007029 D-loop; other site 443218007030 H-loop/switch region; other site 443218007031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218007032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218007033 substrate binding pocket [chemical binding]; other site 443218007034 membrane-bound complex binding site; other site 443218007035 hinge residues; other site 443218007036 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443218007037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007038 dimer interface [polypeptide binding]; other site 443218007039 conserved gate region; other site 443218007040 putative PBP binding loops; other site 443218007041 ABC-ATPase subunit interface; other site 443218007042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007043 dimer interface [polypeptide binding]; other site 443218007044 conserved gate region; other site 443218007045 putative PBP binding loops; other site 443218007046 ABC-ATPase subunit interface; other site 443218007047 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218007048 hydrophobic ligand binding site; other site 443218007049 acyl-CoA synthetase; Validated; Region: PRK07788 443218007050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218007051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218007052 acyl-activating enzyme (AAE) consensus motif; other site 443218007053 AMP binding site [chemical binding]; other site 443218007054 active site 443218007055 acyl-activating enzyme (AAE) consensus motif; other site 443218007056 CoA binding site [chemical binding]; other site 443218007057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218007058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218007059 putative acyl-acceptor binding pocket; other site 443218007060 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007061 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218007062 DNA binding residues [nucleotide binding] 443218007063 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218007064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218007065 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218007066 classical (c) SDRs; Region: SDR_c; cd05233 443218007067 NAD(P) binding site [chemical binding]; other site 443218007068 active site 443218007069 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218007070 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218007071 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218007072 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218007073 FAD binding pocket [chemical binding]; other site 443218007074 FAD binding motif [chemical binding]; other site 443218007075 phosphate binding motif [ion binding]; other site 443218007076 beta-alpha-beta structure motif; other site 443218007077 NAD(p) ribose binding residues [chemical binding]; other site 443218007078 NAD binding pocket [chemical binding]; other site 443218007079 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218007080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007081 catalytic loop [active] 443218007082 iron binding site [ion binding]; other site 443218007083 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 443218007084 classical (c) SDRs; Region: SDR_c; cd05233 443218007085 NAD(P) binding site [chemical binding]; other site 443218007086 active site 443218007087 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218007088 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218007089 active site 443218007090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007091 BioY family; Region: BioY; pfam02632 443218007092 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218007093 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443218007094 Walker A/P-loop; other site 443218007095 ATP binding site [chemical binding]; other site 443218007096 Q-loop/lid; other site 443218007097 ABC transporter signature motif; other site 443218007098 Walker B; other site 443218007099 D-loop; other site 443218007100 H-loop/switch region; other site 443218007101 Cobalt transport protein; Region: CbiQ; cl00463 443218007102 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 443218007103 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218007104 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443218007105 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443218007106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218007107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218007108 DNA binding site [nucleotide binding] 443218007109 domain linker motif; other site 443218007110 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218007111 ligand binding site [chemical binding]; other site 443218007112 dimerization interface [polypeptide binding]; other site 443218007113 Protein of unknown function (DUF419); Region: DUF419; pfam04237 443218007114 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 443218007115 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443218007116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007117 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218007118 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 443218007119 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218007120 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218007121 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443218007122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218007123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218007124 anti sigma factor interaction site; other site 443218007125 regulatory phosphorylation site [posttranslational modification]; other site 443218007126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218007127 active site 443218007128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218007129 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443218007130 GAF domain; Region: GAF; pfam01590 443218007131 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443218007132 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 443218007133 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218007134 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218007135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 443218007136 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443218007137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218007138 motif II; other site 443218007139 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 443218007140 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 443218007141 dimer interface [polypeptide binding]; other site 443218007142 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 443218007143 active site 443218007144 Fe binding site [ion binding]; other site 443218007145 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218007146 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218007147 putative acyl-acceptor binding pocket; other site 443218007148 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443218007149 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 443218007150 TPP-binding site [chemical binding]; other site 443218007151 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443218007152 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443218007153 PYR/PP interface [polypeptide binding]; other site 443218007154 dimer interface [polypeptide binding]; other site 443218007155 TPP binding site [chemical binding]; other site 443218007156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218007157 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218007158 putative dimer interface [polypeptide binding]; other site 443218007159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007160 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 443218007161 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443218007162 potential catalytic triad [active] 443218007163 conserved cys residue [active] 443218007164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218007165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218007166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443218007167 dimerization interface [polypeptide binding]; other site 443218007168 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218007169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218007170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007172 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218007173 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218007174 Isochorismatase family; Region: Isochorismatase; pfam00857 443218007175 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 443218007176 catalytic triad [active] 443218007177 conserved cis-peptide bond; other site 443218007178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007179 S-adenosylmethionine binding site [chemical binding]; other site 443218007180 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 443218007181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218007183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007184 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218007185 putative active site [active] 443218007186 putative metal binding site [ion binding]; other site 443218007187 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218007188 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218007189 iron-sulfur cluster [ion binding]; other site 443218007190 [2Fe-2S] cluster binding site [ion binding]; other site 443218007191 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218007192 active site 443218007193 FMN binding site [chemical binding]; other site 443218007194 substrate binding site [chemical binding]; other site 443218007195 3Fe-4S cluster binding site [ion binding]; other site 443218007196 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007197 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443218007198 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218007199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218007200 sequence-specific DNA binding site [nucleotide binding]; other site 443218007201 salt bridge; other site 443218007202 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218007203 active site 443218007204 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218007205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007206 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443218007207 FMN binding site [chemical binding]; other site 443218007208 dimer interface [polypeptide binding]; other site 443218007209 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443218007210 BCCT family transporter; Region: BCCT; cl00569 443218007211 choline dehydrogenase; Validated; Region: PRK02106 443218007212 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218007213 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 443218007214 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218007215 tetramerization interface [polypeptide binding]; other site 443218007216 NAD(P) binding site [chemical binding]; other site 443218007217 catalytic residues [active] 443218007218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007219 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 443218007220 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 443218007221 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443218007222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443218007223 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218007224 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443218007225 DNA polymerase IV; Validated; Region: PRK03858 443218007226 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218007227 active site 443218007228 DNA binding site [nucleotide binding] 443218007229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218007230 Cation efflux family; Region: Cation_efflux; cl00316 443218007231 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 443218007232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218007233 ATP binding site [chemical binding]; other site 443218007234 putative Mg++ binding site [ion binding]; other site 443218007235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218007236 nucleotide binding region [chemical binding]; other site 443218007237 ATP-binding site [chemical binding]; other site 443218007238 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443218007239 RibD C-terminal domain; Region: RibD_C; cl17279 443218007240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218007241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007242 putative acyltransferase; Provisional; Region: PRK05790 443218007243 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218007244 dimer interface [polypeptide binding]; other site 443218007245 active site 443218007246 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 443218007247 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 443218007248 L-tyrosine decarboxylase; Provisional; Region: PRK13520 443218007249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218007250 catalytic residue [active] 443218007251 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218007252 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 443218007253 active site 443218007254 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218007255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218007256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007257 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 443218007258 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218007259 active site 443218007260 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 443218007261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007262 substrate binding site [chemical binding]; other site 443218007263 oxyanion hole (OAH) forming residues; other site 443218007264 trimer interface [polypeptide binding]; other site 443218007265 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 443218007266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218007267 endonuclease III; Region: ENDO3c; smart00478 443218007268 minor groove reading motif; other site 443218007269 helix-hairpin-helix signature motif; other site 443218007270 active site 443218007271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218007272 phosphate binding site [ion binding]; other site 443218007273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218007274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218007275 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443218007276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007277 dimer interface [polypeptide binding]; other site 443218007278 conserved gate region; other site 443218007279 putative PBP binding loops; other site 443218007280 ABC-ATPase subunit interface; other site 443218007281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218007282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007283 dimer interface [polypeptide binding]; other site 443218007284 conserved gate region; other site 443218007285 putative PBP binding loops; other site 443218007286 ABC-ATPase subunit interface; other site 443218007287 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218007288 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218007289 Walker A/P-loop; other site 443218007290 ATP binding site [chemical binding]; other site 443218007291 Q-loop/lid; other site 443218007292 ABC transporter signature motif; other site 443218007293 Walker B; other site 443218007294 D-loop; other site 443218007295 H-loop/switch region; other site 443218007296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218007297 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 443218007298 ParB-like nuclease domain; Region: ParB; smart00470 443218007299 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 443218007300 Part of AAA domain; Region: AAA_19; pfam13245 443218007301 Family description; Region: UvrD_C_2; pfam13538 443218007302 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218007303 homotrimer interaction site [polypeptide binding]; other site 443218007304 putative active site [active] 443218007305 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218007306 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218007307 iron-sulfur cluster [ion binding]; other site 443218007308 [2Fe-2S] cluster binding site [ion binding]; other site 443218007309 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007310 hydrophobic ligand binding site; other site 443218007311 Anti-Sigma Factor A; Region: AsiA; pfam09010 443218007312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007313 hypothetical protein; Provisional; Region: PRK07064 443218007314 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218007315 PYR/PP interface [polypeptide binding]; other site 443218007316 dimer interface [polypeptide binding]; other site 443218007317 TPP binding site [chemical binding]; other site 443218007318 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443218007319 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443218007320 TPP-binding site [chemical binding]; other site 443218007321 short chain dehydrogenase; Provisional; Region: PRK07062 443218007322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007323 NAD(P) binding site [chemical binding]; other site 443218007324 active site 443218007325 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443218007326 classical (c) SDRs; Region: SDR_c; cd05233 443218007327 NAD(P) binding site [chemical binding]; other site 443218007328 active site 443218007329 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007330 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218007331 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218007332 dimer interface [polypeptide binding]; other site 443218007333 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218007334 active site 443218007335 metal binding site [ion binding]; metal-binding site 443218007336 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 443218007337 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 443218007338 putative active site [active] 443218007339 Mn binding site [ion binding]; other site 443218007340 putative oligomer interface [polypeptide binding]; other site 443218007341 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218007342 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218007343 FMN-binding pocket [chemical binding]; other site 443218007344 flavin binding motif; other site 443218007345 phosphate binding motif [ion binding]; other site 443218007346 beta-alpha-beta structure motif; other site 443218007347 NAD binding pocket [chemical binding]; other site 443218007348 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007349 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218007350 catalytic loop [active] 443218007351 iron binding site [ion binding]; other site 443218007352 Cupin domain; Region: Cupin_2; cl17218 443218007353 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218007354 homotrimer interaction site [polypeptide binding]; other site 443218007355 putative active site [active] 443218007356 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218007357 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 443218007358 NAD(P) binding site [chemical binding]; other site 443218007359 catalytic residues [active] 443218007360 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218007361 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 443218007362 Walker A/P-loop; other site 443218007363 ATP binding site [chemical binding]; other site 443218007364 Q-loop/lid; other site 443218007365 ABC transporter signature motif; other site 443218007366 Walker B; other site 443218007367 D-loop; other site 443218007368 H-loop/switch region; other site 443218007369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218007370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218007371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007372 dimer interface [polypeptide binding]; other site 443218007373 conserved gate region; other site 443218007374 putative PBP binding loops; other site 443218007375 ABC-ATPase subunit interface; other site 443218007376 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 443218007377 NMT1-like family; Region: NMT1_2; pfam13379 443218007378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218007379 MarR family; Region: MarR_2; cl17246 443218007380 YCII-related domain; Region: YCII; cl00999 443218007381 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218007382 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218007383 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443218007384 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218007385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007387 DNA binding residues [nucleotide binding] 443218007388 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218007389 Uncharacterized conserved protein [Function unknown]; Region: COG3379 443218007390 heat shock protein 90; Provisional; Region: PRK05218 443218007391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218007392 ATP binding site [chemical binding]; other site 443218007393 Mg2+ binding site [ion binding]; other site 443218007394 G-X-G motif; other site 443218007395 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 443218007396 active site 443218007397 homotetramer interface [polypeptide binding]; other site 443218007398 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218007399 CoenzymeA binding site [chemical binding]; other site 443218007400 subunit interaction site [polypeptide binding]; other site 443218007401 PHB binding site; other site 443218007402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 443218007403 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443218007404 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 443218007405 putative hydrophobic ligand binding site [chemical binding]; other site 443218007406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218007407 dimerization interface [polypeptide binding]; other site 443218007408 putative DNA binding site [nucleotide binding]; other site 443218007409 putative Zn2+ binding site [ion binding]; other site 443218007410 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 443218007411 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218007412 Putative serine esterase (DUF676); Region: DUF676; pfam05057 443218007413 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218007414 FAD binding domain; Region: FAD_binding_4; pfam01565 443218007415 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443218007416 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218007417 Amidase; Region: Amidase; cl11426 443218007418 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443218007419 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218007420 Ligand Binding Site [chemical binding]; other site 443218007421 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443218007422 LemA family; Region: LemA; cl00742 443218007423 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218007424 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218007425 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 443218007426 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 443218007427 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218007428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218007429 DNA-binding site [nucleotide binding]; DNA binding site 443218007430 FCD domain; Region: FCD; pfam07729 443218007431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218007432 RNA binding surface [nucleotide binding]; other site 443218007433 Secretory lipase; Region: LIP; pfam03583 443218007434 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 443218007435 intracellular protease, PfpI family; Region: PfpI; TIGR01382 443218007436 proposed catalytic triad [active] 443218007437 conserved cys residue [active] 443218007438 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 443218007439 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 443218007440 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218007441 hypothetical protein; Provisional; Region: PRK06753 443218007442 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007443 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218007444 DNA binding residues [nucleotide binding] 443218007445 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 443218007446 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218007447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007448 S-adenosylmethionine binding site [chemical binding]; other site 443218007449 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218007450 iron-sulfur cluster [ion binding]; other site 443218007451 [2Fe-2S] cluster binding site [ion binding]; other site 443218007452 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 443218007453 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218007454 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218007455 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443218007456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007458 DNA binding residues [nucleotide binding] 443218007459 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 443218007460 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 443218007461 putative dimer interface [polypeptide binding]; other site 443218007462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007465 FtsI repressor; Provisional; Region: PRK10883 443218007466 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443218007467 Multicopper oxidase; Region: Cu-oxidase; pfam00394 443218007468 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443218007469 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443218007470 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443218007471 putative substrate binding site [chemical binding]; other site 443218007472 putative ATP binding site [chemical binding]; other site 443218007473 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218007474 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443218007475 Transglycosylase; Region: Transgly; pfam00912 443218007476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218007477 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 443218007478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007479 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443218007480 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218007481 HTH domain; Region: HTH_11; pfam08279 443218007482 WYL domain; Region: WYL; pfam13280 443218007483 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 443218007484 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443218007485 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443218007486 putative active site [active] 443218007487 putative metal binding site [ion binding]; other site 443218007488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007489 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 443218007490 active site 443218007491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218007492 active site 1 [active] 443218007493 active site 2 [active] 443218007494 acyl-CoA synthetase; Validated; Region: PRK07788 443218007495 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218007496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218007497 acyl-activating enzyme (AAE) consensus motif; other site 443218007498 AMP binding site [chemical binding]; other site 443218007499 active site 443218007500 CoA binding site [chemical binding]; other site 443218007501 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 443218007502 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218007503 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218007504 TIGR03086 family protein; Region: TIGR03086 443218007505 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218007506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218007507 FAD binding domain; Region: FAD_binding_4; pfam01565 443218007508 Berberine and berberine like; Region: BBE; pfam08031 443218007509 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443218007510 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443218007511 Multicopper oxidase; Region: Cu-oxidase; pfam00394 443218007512 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443218007513 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 443218007514 POT family; Region: PTR2; cl17359 443218007515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007516 NRDE protein; Region: NRDE; cl01315 443218007517 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218007518 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218007519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007520 active site 443218007521 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218007522 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443218007523 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443218007524 trimer interface [polypeptide binding]; other site 443218007525 putative metal binding site [ion binding]; other site 443218007526 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 443218007527 putative catalytic residue [active] 443218007528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218007529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218007530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218007531 dimerization interface [polypeptide binding]; other site 443218007532 enoyl-CoA hydratase; Provisional; Region: PRK05862 443218007533 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007534 substrate binding site [chemical binding]; other site 443218007535 oxyanion hole (OAH) forming residues; other site 443218007536 trimer interface [polypeptide binding]; other site 443218007537 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443218007538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007539 NAD(P) binding site [chemical binding]; other site 443218007540 catalytic residues [active] 443218007541 short chain dehydrogenase; Provisional; Region: PRK07825 443218007542 classical (c) SDRs; Region: SDR_c; cd05233 443218007543 NAD(P) binding site [chemical binding]; other site 443218007544 active site 443218007545 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218007546 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218007547 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218007548 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218007549 FAD binding pocket [chemical binding]; other site 443218007550 FAD binding motif [chemical binding]; other site 443218007551 phosphate binding motif [ion binding]; other site 443218007552 beta-alpha-beta structure motif; other site 443218007553 NAD binding pocket [chemical binding]; other site 443218007554 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007555 catalytic loop [active] 443218007556 iron binding site [ion binding]; other site 443218007557 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218007558 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 443218007559 putative di-iron ligands [ion binding]; other site 443218007560 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218007561 Conserved membrane protein YqhR; Region: YqhR; pfam11085 443218007562 H+ Antiporter protein; Region: 2A0121; TIGR00900 443218007563 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 443218007564 putative FMN binding site [chemical binding]; other site 443218007565 NADPH bind site [chemical binding]; other site 443218007566 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 443218007567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218007568 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218007569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007570 substrate binding site [chemical binding]; other site 443218007571 oxyanion hole (OAH) forming residues; other site 443218007572 trimer interface [polypeptide binding]; other site 443218007573 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218007574 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443218007575 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218007576 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218007577 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443218007578 active site 443218007579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007580 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218007581 NAD(P) binding site [chemical binding]; other site 443218007582 active site 443218007583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007584 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007585 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218007586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007587 NAD(P) binding site [chemical binding]; other site 443218007588 active site 443218007589 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007590 hydrophobic ligand binding site; other site 443218007591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218007592 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 443218007593 Walker A/P-loop; other site 443218007594 ATP binding site [chemical binding]; other site 443218007595 Q-loop/lid; other site 443218007596 ABC transporter signature motif; other site 443218007597 Walker B; other site 443218007598 D-loop; other site 443218007599 H-loop/switch region; other site 443218007600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218007601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218007602 non-specific DNA binding site [nucleotide binding]; other site 443218007603 salt bridge; other site 443218007604 sequence-specific DNA binding site [nucleotide binding]; other site 443218007605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218007606 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443218007607 Walker A/P-loop; other site 443218007608 ATP binding site [chemical binding]; other site 443218007609 Q-loop/lid; other site 443218007610 ABC transporter signature motif; other site 443218007611 Walker B; other site 443218007612 D-loop; other site 443218007613 H-loop/switch region; other site 443218007614 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443218007615 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 443218007616 Walker A/P-loop; other site 443218007617 ATP binding site [chemical binding]; other site 443218007618 Q-loop/lid; other site 443218007619 ABC transporter signature motif; other site 443218007620 Walker B; other site 443218007621 D-loop; other site 443218007622 H-loop/switch region; other site 443218007623 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443218007624 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443218007625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007626 dimer interface [polypeptide binding]; other site 443218007627 conserved gate region; other site 443218007628 putative PBP binding loops; other site 443218007629 ABC-ATPase subunit interface; other site 443218007630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443218007631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007632 dimer interface [polypeptide binding]; other site 443218007633 conserved gate region; other site 443218007634 putative PBP binding loops; other site 443218007635 ABC-ATPase subunit interface; other site 443218007636 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443218007637 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 443218007638 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 443218007639 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218007640 putative substrate binding site [chemical binding]; other site 443218007641 putative ATP binding site [chemical binding]; other site 443218007642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443218007643 DNA-binding site [nucleotide binding]; DNA binding site 443218007644 RNA-binding motif; other site 443218007645 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218007646 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218007647 active site 2 [active] 443218007648 active site 1 [active] 443218007649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007651 WHG domain; Region: WHG; pfam13305 443218007652 potassium/proton antiporter; Reviewed; Region: PRK05326 443218007653 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443218007654 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218007655 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218007656 acyl-activating enzyme (AAE) consensus motif; other site 443218007657 putative AMP binding site [chemical binding]; other site 443218007658 putative active site [active] 443218007659 putative CoA binding site [chemical binding]; other site 443218007660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007662 active site 443218007663 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218007664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218007665 DNA-binding site [nucleotide binding]; DNA binding site 443218007666 FCD domain; Region: FCD; pfam07729 443218007667 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218007668 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443218007669 putative [Fe4-S4] binding site [ion binding]; other site 443218007670 putative molybdopterin cofactor binding site [chemical binding]; other site 443218007671 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218007672 putative molybdopterin cofactor binding site; other site 443218007673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007675 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443218007676 enoyl-CoA hydratase; Provisional; Region: PRK06688 443218007677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007678 substrate binding site [chemical binding]; other site 443218007679 oxyanion hole (OAH) forming residues; other site 443218007680 trimer interface [polypeptide binding]; other site 443218007681 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443218007682 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218007683 FMN binding site [chemical binding]; other site 443218007684 substrate binding site [chemical binding]; other site 443218007685 putative catalytic residue [active] 443218007686 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 443218007687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007688 substrate binding site [chemical binding]; other site 443218007689 oxyanion hole (OAH) forming residues; other site 443218007690 trimer interface [polypeptide binding]; other site 443218007691 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443218007692 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218007693 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443218007694 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218007695 dimer interface [polypeptide binding]; other site 443218007696 active site 443218007697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007701 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 443218007702 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 443218007703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007704 AlkA N-terminal domain; Region: AlkA_N; pfam06029 443218007705 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443218007706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218007707 minor groove reading motif; other site 443218007708 helix-hairpin-helix signature motif; other site 443218007709 substrate binding pocket [chemical binding]; other site 443218007710 active site 443218007711 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443218007712 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218007713 DNA binding site [nucleotide binding] 443218007714 active site 443218007715 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443218007716 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 443218007717 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443218007718 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 443218007719 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 443218007720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007722 active site 443218007723 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443218007724 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443218007725 tetrameric interface [polypeptide binding]; other site 443218007726 NAD binding site [chemical binding]; other site 443218007727 catalytic residues [active] 443218007728 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218007729 MarR family; Region: MarR; pfam01047 443218007730 Secretory lipase; Region: LIP; pfam03583 443218007731 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 443218007732 Strictosidine synthase; Region: Str_synth; pfam03088 443218007733 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 443218007734 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 443218007735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007736 S-adenosylmethionine binding site [chemical binding]; other site 443218007737 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 443218007738 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443218007739 active site 443218007740 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218007741 active site 443218007742 metal binding site [ion binding]; metal-binding site 443218007743 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218007744 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218007745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218007746 Transporter associated domain; Region: CorC_HlyC; pfam03471 443218007747 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218007748 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218007749 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218007750 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 443218007751 active site 443218007752 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 443218007753 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218007754 Protein of unknown function DUF58; Region: DUF58; pfam01882 443218007755 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218007756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218007757 Walker A motif; other site 443218007758 ATP binding site [chemical binding]; other site 443218007759 Walker B motif; other site 443218007760 arginine finger; other site 443218007761 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443218007762 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443218007763 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 443218007764 RDD family; Region: RDD; pfam06271 443218007765 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 443218007766 VanW like protein; Region: VanW; pfam04294 443218007767 DNA polymerase IV; Provisional; Region: PRK03348 443218007768 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218007769 active site 443218007770 DNA binding site [nucleotide binding] 443218007771 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 443218007772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218007773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218007774 catalytic residue [active] 443218007775 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007776 hydrophobic ligand binding site; other site 443218007777 active site 443218007778 catalytic triad [active] 443218007779 oxyanion hole [active] 443218007780 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443218007781 RDD family; Region: RDD; pfam06271 443218007782 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218007783 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007784 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007785 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 443218007786 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 443218007787 putative active site [active] 443218007788 metal binding site [ion binding]; metal-binding site 443218007789 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443218007790 putative catalytic site [active] 443218007791 putative metal binding site [ion binding]; other site 443218007792 putative phosphate binding site [ion binding]; other site 443218007793 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 443218007794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007795 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218007796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007797 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 443218007798 Septum formation; Region: Septum_form; pfam13845 443218007799 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443218007800 putative active site [active] 443218007801 putative CoA binding site [chemical binding]; other site 443218007802 nudix motif; other site 443218007803 metal binding site [ion binding]; metal-binding site 443218007804 choline dehydrogenase; Validated; Region: PRK02106 443218007805 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218007806 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443218007807 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007808 NAD(P) binding site [chemical binding]; other site 443218007809 catalytic residues [active] 443218007810 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218007811 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218007812 active site 443218007813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218007814 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 443218007815 Walker A/P-loop; other site 443218007816 ATP binding site [chemical binding]; other site 443218007817 Q-loop/lid; other site 443218007818 ABC transporter signature motif; other site 443218007819 Walker B; other site 443218007820 D-loop; other site 443218007821 H-loop/switch region; other site 443218007822 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443218007823 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218007824 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 443218007825 putative NAD(P) binding site [chemical binding]; other site 443218007826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007827 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218007829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007830 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443218007831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007833 DNA binding residues [nucleotide binding] 443218007834 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218007835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218007836 putative acyl-acceptor binding pocket; other site 443218007837 Amino acid permease; Region: AA_permease_2; pfam13520 443218007838 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218007839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218007840 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218007842 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218007843 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 443218007844 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 443218007845 tetrameric interface [polypeptide binding]; other site 443218007846 NAD binding site [chemical binding]; other site 443218007847 catalytic residues [active] 443218007848 substrate binding site [chemical binding]; other site 443218007849 DsrE/DsrF-like family; Region: DrsE; pfam02635 443218007850 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007851 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007852 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443218007853 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218007854 active site 443218007855 TDP-binding site; other site 443218007856 acceptor substrate-binding pocket; other site 443218007857 homodimer interface [polypeptide binding]; other site 443218007858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218007859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007860 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218007861 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218007862 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218007863 active site 443218007864 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443218007865 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 443218007866 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443218007867 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218007868 phosphate binding site [ion binding]; other site 443218007869 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 443218007870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218007871 phosphate binding site [ion binding]; other site 443218007872 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218007873 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218007874 active site 443218007875 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218007876 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443218007877 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 443218007878 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443218007879 putative NADP binding site [chemical binding]; other site 443218007880 active site 443218007881 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 443218007882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218007883 putative DNA binding site [nucleotide binding]; other site 443218007884 putative Zn2+ binding site [ion binding]; other site 443218007885 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443218007886 putative hydrophobic ligand binding site [chemical binding]; other site 443218007887 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007888 hydrophobic ligand binding site; other site 443218007889 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007890 DNA binding residues [nucleotide binding] 443218007891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007892 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218007893 DNA binding residues [nucleotide binding] 443218007894 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218007895 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218007896 FAD binding pocket [chemical binding]; other site 443218007897 FAD binding motif [chemical binding]; other site 443218007898 phosphate binding motif [ion binding]; other site 443218007899 NAD binding pocket [chemical binding]; other site 443218007900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218007901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218007902 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007903 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 443218007904 NAD(P) binding site [chemical binding]; other site 443218007905 catalytic residues [active] 443218007906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007908 active site 443218007909 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443218007910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218007911 inhibitor-cofactor binding pocket; inhibition site 443218007912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218007913 catalytic residue [active] 443218007914 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218007915 Amino acid permease; Region: AA_permease_2; pfam13520 443218007916 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 443218007917 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218007918 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218007919 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218007920 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 443218007921 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 443218007922 active site 443218007923 DNA binding site [nucleotide binding] 443218007924 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 443218007925 DNA binding site [nucleotide binding] 443218007926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007928 S-adenosylmethionine binding site [chemical binding]; other site 443218007929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218007930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218007931 ATP binding site [chemical binding]; other site 443218007932 Mg2+ binding site [ion binding]; other site 443218007933 G-X-G motif; other site 443218007934 Predicted membrane protein [Function unknown]; Region: COG4270 443218007935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007936 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218007937 active site 443218007938 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443218007939 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218007940 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443218007941 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443218007942 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218007943 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443218007944 putative DNA binding site [nucleotide binding]; other site 443218007945 putative Zn2+ binding site [ion binding]; other site 443218007946 AsnC family; Region: AsnC_trans_reg; pfam01037 443218007947 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 443218007948 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 443218007949 dimer interface [polypeptide binding]; other site 443218007950 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 443218007951 active site 443218007952 Fe binding site [ion binding]; other site 443218007953 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218007954 Ligand Binding Site [chemical binding]; other site 443218007955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007956 S-adenosylmethionine binding site [chemical binding]; other site 443218007957 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 443218007958 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443218007959 fumarylacetoacetase; Region: PLN02856 443218007960 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 443218007961 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443218007962 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 443218007963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218007964 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443218007965 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443218007966 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218007967 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218007968 metabolite-proton symporter; Region: 2A0106; TIGR00883 443218007969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007970 putative substrate translocation pore; other site 443218007971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218007972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218007973 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 443218007974 putative substrate binding pocket [chemical binding]; other site 443218007975 dimerization interface [polypeptide binding]; other site 443218007976 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 443218007977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218007978 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218007979 RibD C-terminal domain; Region: RibD_C; cl17279 443218007980 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443218007981 CAAX protease self-immunity; Region: Abi; pfam02517 443218007982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218007983 MarR family; Region: MarR_2; pfam12802 443218007984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218007986 putative substrate translocation pore; other site 443218007987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007988 endonuclease IV; Provisional; Region: PRK01060 443218007989 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443218007990 AP (apurinic/apyrimidinic) site pocket; other site 443218007991 DNA interaction; other site 443218007992 Metal-binding active site; metal-binding site 443218007993 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007994 NAD(P) binding site [chemical binding]; other site 443218007995 catalytic residues [active] 443218007996 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218007997 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 443218007998 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218007999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218008000 catalytic residue [active] 443218008001 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 443218008002 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 443218008003 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218008004 Na binding site [ion binding]; other site 443218008005 Beta-lactamase; Region: Beta-lactamase; pfam00144 443218008006 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218008007 biotin carboxylase-like protein; Validated; Region: PRK06524 443218008008 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218008009 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 443218008010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008011 putative substrate translocation pore; other site 443218008012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218008014 dimerization interface [polypeptide binding]; other site 443218008015 putative DNA binding site [nucleotide binding]; other site 443218008016 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218008017 putative Zn2+ binding site [ion binding]; other site 443218008018 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218008019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443218008020 nucleotide binding site [chemical binding]; other site 443218008021 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443218008022 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218008023 ATP binding site [chemical binding]; other site 443218008024 substrate binding site [chemical binding]; other site 443218008025 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443218008026 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443218008027 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443218008028 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443218008029 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443218008030 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443218008031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218008032 motif II; other site 443218008033 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218008034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008036 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443218008037 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218008038 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218008039 active site 443218008040 catalytic triad [active] 443218008041 oxyanion hole [active] 443218008042 Protein of unknown function DUF72; Region: DUF72; pfam01904 443218008043 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 443218008044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008046 DNA binding residues [nucleotide binding] 443218008047 dimerization interface [polypeptide binding]; other site 443218008048 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218008049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218008050 Domain of unknown function (DUF427); Region: DUF427; cl00998 443218008051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443218008052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008054 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218008055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218008056 catalytic loop [active] 443218008057 iron binding site [ion binding]; other site 443218008058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218008059 Cytochrome P450; Region: p450; cl12078 443218008060 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218008061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218008062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218008063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218008064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008065 putative substrate translocation pore; other site 443218008066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218008067 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 443218008068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218008069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218008070 DNA binding residues [nucleotide binding] 443218008071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008073 AAA domain; Region: AAA_23; pfam13476 443218008074 Walker A/P-loop; other site 443218008075 ATP binding site [chemical binding]; other site 443218008076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008077 ABC transporter signature motif; other site 443218008078 Walker B; other site 443218008079 D-loop; other site 443218008080 H-loop/switch region; other site 443218008081 Protein of unknown function DUF262; Region: DUF262; pfam03235 443218008082 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218008083 Uncharacterized conserved protein [Function unknown]; Region: COG3472 443218008084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218008085 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 443218008086 Walker A motif; other site 443218008087 ATP binding site [chemical binding]; other site 443218008088 Walker B motif; other site 443218008089 Uncharacterized conserved protein [Function unknown]; Region: COG3410 443218008090 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 443218008091 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 443218008092 PLD-like domain; Region: PLDc_2; pfam13091 443218008093 putative homodimer interface [polypeptide binding]; other site 443218008094 putative active site [active] 443218008095 catalytic site [active] 443218008096 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 443218008097 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218008098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218008099 ATP binding site [chemical binding]; other site 443218008100 putative Mg++ binding site [ion binding]; other site 443218008101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218008102 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443218008103 nucleotide binding region [chemical binding]; other site 443218008104 ATP-binding site [chemical binding]; other site 443218008105 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218008106 Active Sites [active] 443218008107 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 443218008108 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443218008109 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443218008110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218008111 catalytic residue [active] 443218008112 Protein of unknown function DUF262; Region: DUF262; pfam03235 443218008113 Uncharacterized conserved protein [Function unknown]; Region: COG1479 443218008114 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443218008115 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443218008116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008117 S-adenosylmethionine binding site [chemical binding]; other site 443218008118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008120 DNA binding residues [nucleotide binding] 443218008121 dimerization interface [polypeptide binding]; other site 443218008122 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218008123 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218008124 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218008125 TIGR03086 family protein; Region: TIGR03086 443218008126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008128 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218008129 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 443218008130 metal binding site [ion binding]; metal-binding site 443218008131 transcriptional regulator NarP; Provisional; Region: PRK10403 443218008132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443218008133 active site 443218008134 phosphorylation site [posttranslational modification] 443218008135 intermolecular recognition site; other site 443218008136 dimerization interface [polypeptide binding]; other site 443218008137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008138 DNA binding residues [nucleotide binding] 443218008139 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443218008140 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 443218008141 PQQ-like domain; Region: PQQ_2; pfam13360 443218008142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218008143 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218008144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008146 DNA binding residues [nucleotide binding] 443218008147 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 443218008148 dimerization interface [polypeptide binding]; other site 443218008149 DNA binding residues [nucleotide binding] 443218008150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218008151 non-specific DNA binding site [nucleotide binding]; other site 443218008152 salt bridge; other site 443218008153 sequence-specific DNA binding site [nucleotide binding]; other site 443218008154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008155 Walker A/P-loop; other site 443218008156 ATP binding site [chemical binding]; other site 443218008157 FOG: WD40 repeat [General function prediction only]; Region: COG2319 443218008158 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 443218008159 structural tetrad; other site 443218008160 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 443218008161 structural tetrad; other site 443218008162 FOG: WD40 repeat [General function prediction only]; Region: COG2319 443218008163 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 443218008164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008166 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443218008167 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 443218008168 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 443218008169 putative active site [active] 443218008170 putative metal binding site [ion binding]; other site 443218008171 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443218008172 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443218008173 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 443218008174 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443218008175 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218008176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218008177 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218008178 acyl-activating enzyme (AAE) consensus motif; other site 443218008179 putative AMP binding site [chemical binding]; other site 443218008180 putative active site [active] 443218008181 putative CoA binding site [chemical binding]; other site 443218008182 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 443218008183 putative acyl-acceptor binding pocket; other site 443218008184 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218008185 Cytochrome P450; Region: p450; cl12078 443218008186 Ferredoxin [Energy production and conversion]; Region: COG1146 443218008187 4Fe-4S binding domain; Region: Fer4; pfam00037 443218008188 ferredoxin-NADP+ reductase; Region: PLN02852 443218008189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008191 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218008192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218008193 Walker A/P-loop; other site 443218008194 ATP binding site [chemical binding]; other site 443218008195 Q-loop/lid; other site 443218008196 ABC transporter signature motif; other site 443218008197 Walker B; other site 443218008198 D-loop; other site 443218008199 H-loop/switch region; other site 443218008200 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218008201 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218008202 putative active site [active] 443218008203 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218008204 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443218008205 AAA ATPase domain; Region: AAA_16; pfam13191 443218008206 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 443218008207 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218008208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218008209 active site 443218008210 metal binding site [ion binding]; metal-binding site 443218008211 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218008212 nudix motif; other site 443218008213 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 443218008214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 443218008215 MarR family; Region: MarR_2; pfam12802 443218008216 Cupin domain; Region: Cupin_2; pfam07883 443218008217 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443218008218 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218008219 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 443218008220 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443218008221 putative ligand binding site [chemical binding]; other site 443218008222 putative NAD binding site [chemical binding]; other site 443218008223 catalytic site [active] 443218008224 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218008225 catalytic core [active] 443218008226 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218008227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218008228 nucleotide binding site [chemical binding]; other site 443218008229 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218008230 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 443218008231 putative N- and C-terminal domain interface [polypeptide binding]; other site 443218008232 putative active site [active] 443218008233 MgATP binding site [chemical binding]; other site 443218008234 catalytic site [active] 443218008235 metal binding site [ion binding]; metal-binding site 443218008236 putative xylulose binding site [chemical binding]; other site 443218008237 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443218008238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218008239 polyol permease family; Region: 2A0118; TIGR00897 443218008240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008241 putative substrate translocation pore; other site 443218008242 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443218008243 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 443218008244 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 443218008245 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218008246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008248 short chain dehydrogenase; Provisional; Region: PRK06197 443218008249 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218008250 putative NAD(P) binding site [chemical binding]; other site 443218008251 active site 443218008252 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 443218008253 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 443218008254 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218008255 putative active site [active] 443218008256 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443218008257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008258 S-adenosylmethionine binding site [chemical binding]; other site 443218008259 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443218008260 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443218008261 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443218008262 dimer interface [polypeptide binding]; other site 443218008263 active site 443218008264 CoA binding pocket [chemical binding]; other site 443218008265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218008266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218008267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218008268 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443218008269 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443218008270 dimer interface [polypeptide binding]; other site 443218008271 active site 443218008272 CoA binding pocket [chemical binding]; other site 443218008273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008275 Protease prsW family; Region: PrsW-protease; pfam13367 443218008276 Bacterial PH domain; Region: DUF304; pfam03703 443218008277 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 443218008278 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443218008279 putative active site [active] 443218008280 catalytic site [active] 443218008281 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 443218008282 putative active site [active] 443218008283 catalytic site [active] 443218008284 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 443218008285 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 443218008286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218008287 non-specific DNA binding site [nucleotide binding]; other site 443218008288 salt bridge; other site 443218008289 sequence-specific DNA binding site [nucleotide binding]; other site 443218008290 Cupin domain; Region: Cupin_2; pfam07883 443218008291 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 443218008292 nucleotide binding site [chemical binding]; other site 443218008293 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443218008294 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443218008295 active site 443218008296 DNA binding site [nucleotide binding] 443218008297 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443218008298 DNA binding site [nucleotide binding] 443218008299 Patatin-like phospholipase; Region: Patatin; pfam01734 443218008300 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218008301 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218008302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218008303 Cytochrome P450; Region: p450; cl12078 443218008304 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008306 putative substrate translocation pore; other site 443218008307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218008309 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218008310 hypothetical protein; Provisional; Region: PRK06849 443218008311 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218008312 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443218008313 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443218008314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218008315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218008316 Yqey-like protein; Region: YqeY; pfam09424 443218008317 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218008318 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 443218008319 Domain of unknown function (DUF305); Region: DUF305; pfam03713 443218008320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218008321 Cytochrome P450; Region: p450; cl12078 443218008322 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218008323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443218008324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218008325 protein binding site [polypeptide binding]; other site 443218008326 Putative transcription activator [Transcription]; Region: TenA; COG0819 443218008327 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218008328 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 443218008329 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443218008330 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443218008331 putative NAD(P) binding site [chemical binding]; other site 443218008332 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 443218008333 Fe-S cluster binding site [ion binding]; other site 443218008334 DNA binding site [nucleotide binding] 443218008335 active site 443218008336 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 443218008337 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218008338 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 443218008339 NAD binding site [chemical binding]; other site 443218008340 Phe binding site; other site 443218008341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008342 S-adenosylmethionine binding site [chemical binding]; other site 443218008343 benzoate transport; Region: 2A0115; TIGR00895 443218008344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008345 putative substrate translocation pore; other site 443218008346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008348 Protein of unknown function (DUF952); Region: DUF952; pfam06108 443218008349 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443218008350 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443218008351 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218008352 Uncharacterized conserved protein [Function unknown]; Region: COG1739 443218008353 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 443218008354 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 443218008355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218008356 dimerization interface [polypeptide binding]; other site 443218008357 putative DNA binding site [nucleotide binding]; other site 443218008358 putative Zn2+ binding site [ion binding]; other site 443218008359 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218008360 hydrophobic ligand binding site; other site 443218008361 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218008362 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218008363 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218008365 active site 443218008366 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443218008367 active site 443218008368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443218008369 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443218008370 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443218008371 BCCT family transporter; Region: BCCT; pfam02028 443218008372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218008374 active site 443218008375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218008377 active site 443218008378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008379 active site 443218008380 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443218008381 putative active site [active] 443218008382 putative catalytic site [active] 443218008383 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 443218008384 Iron-sulfur protein interface; other site 443218008385 proximal heme binding site [chemical binding]; other site 443218008386 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 443218008387 Iron-sulfur protein interface; other site 443218008388 proximal heme binding site [chemical binding]; other site 443218008389 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 443218008390 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443218008391 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 443218008392 L-aspartate oxidase; Provisional; Region: PRK06175 443218008393 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218008394 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 443218008395 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443218008396 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443218008397 Family description; Region: UvrD_C_2; pfam13538 443218008398 Phosphotransferase enzyme family; Region: APH; pfam01636 443218008399 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443218008400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443218008401 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 443218008402 AAA domain; Region: AAA_30; pfam13604 443218008403 Family description; Region: UvrD_C_2; pfam13538 443218008404 Amino acid permease; Region: AA_permease_2; pfam13520 443218008405 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218008406 iron-sulfur cluster [ion binding]; other site 443218008407 [2Fe-2S] cluster binding site [ion binding]; other site 443218008408 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 443218008409 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443218008410 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218008411 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 443218008412 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 443218008413 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 443218008414 ethanolamine permease; Region: 2A0305; TIGR00908 443218008415 enoyl-CoA hydratase; Provisional; Region: PRK06142 443218008416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008417 substrate binding site [chemical binding]; other site 443218008418 oxyanion hole (OAH) forming residues; other site 443218008419 trimer interface [polypeptide binding]; other site 443218008420 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443218008421 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218008422 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 443218008423 oligomer interface [polypeptide binding]; other site 443218008424 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443218008425 EspG family; Region: ESX-1_EspG; pfam14011 443218008426 Condensation domain; Region: Condensation; pfam00668 443218008427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218008428 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 443218008429 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443218008430 DinB superfamily; Region: DinB_2; pfam12867 443218008431 Domain of unknown function (DUF202); Region: DUF202; cl09954 443218008432 HNH endonuclease; Region: HNH_4; pfam13395 443218008433 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 443218008434 diiron binding motif [ion binding]; other site 443218008435 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 443218008436 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443218008437 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443218008438 TrkA-N domain; Region: TrkA_N; pfam02254 443218008439 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443218008440 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443218008441 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 443218008442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008443 NAD(P) binding site [chemical binding]; other site 443218008444 active site 443218008445 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218008446 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218008447 catalytic residues [active] 443218008448 catalytic nucleophile [active] 443218008449 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218008450 Probable transposase; Region: OrfB_IS605; pfam01385 443218008451 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218008452 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 443218008453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 443218008454 MOSC domain; Region: MOSC; pfam03473 443218008455 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218008456 Cytochrome P450; Region: p450; cl12078 443218008457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008459 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443218008460 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443218008461 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218008462 active site 443218008463 catalytic site [active] 443218008464 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 443218008465 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 443218008466 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 443218008467 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218008468 putative NAD(P) binding site [chemical binding]; other site 443218008469 putative active site [active] 443218008470 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 443218008471 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218008472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008473 Walker A/P-loop; other site 443218008474 ATP binding site [chemical binding]; other site 443218008475 ABC transporter signature motif; other site 443218008476 Walker B; other site 443218008477 D-loop; other site 443218008478 H-loop/switch region; other site 443218008479 ABC transporter; Region: ABC_tran_2; pfam12848 443218008480 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218008481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218008482 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443218008483 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218008484 Walker A/P-loop; other site 443218008485 ATP binding site [chemical binding]; other site 443218008486 Q-loop/lid; other site 443218008487 ABC transporter signature motif; other site 443218008488 Walker B; other site 443218008489 D-loop; other site 443218008490 H-loop/switch region; other site 443218008491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218008492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218008493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008494 Walker A/P-loop; other site 443218008495 ATP binding site [chemical binding]; other site 443218008496 Q-loop/lid; other site 443218008497 ABC transporter signature motif; other site 443218008498 Walker B; other site 443218008499 D-loop; other site 443218008500 H-loop/switch region; other site 443218008501 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443218008502 Aspartase; Region: Aspartase; cd01357 443218008503 active sites [active] 443218008504 tetramer interface [polypeptide binding]; other site 443218008505 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 443218008506 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443218008507 NAD binding site [chemical binding]; other site 443218008508 ligand binding site [chemical binding]; other site 443218008509 catalytic site [active] 443218008510 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 443218008511 tartrate dehydrogenase; Provisional; Region: PRK08194 443218008512 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218008513 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218008514 NAD(P) binding site [chemical binding]; other site 443218008515 catalytic residues [active] 443218008516 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 443218008517 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218008518 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 443218008519 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 443218008520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218008521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218008522 substrate binding pocket [chemical binding]; other site 443218008523 membrane-bound complex binding site; other site 443218008524 hinge residues; other site 443218008525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443218008526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218008527 dimer interface [polypeptide binding]; other site 443218008528 conserved gate region; other site 443218008529 putative PBP binding loops; other site 443218008530 ABC-ATPase subunit interface; other site 443218008531 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218008532 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443218008533 Walker A/P-loop; other site 443218008534 ATP binding site [chemical binding]; other site 443218008535 Q-loop/lid; other site 443218008536 ABC transporter signature motif; other site 443218008537 Walker B; other site 443218008538 D-loop; other site 443218008539 H-loop/switch region; other site 443218008540 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 443218008541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443218008542 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 443218008543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218008544 inhibitor-cofactor binding pocket; inhibition site 443218008545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008546 catalytic residue [active] 443218008547 succinic semialdehyde dehydrogenase; Region: PLN02278 443218008548 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218008549 tetramerization interface [polypeptide binding]; other site 443218008550 NAD(P) binding site [chemical binding]; other site 443218008551 catalytic residues [active] 443218008552 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218008553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008554 DNA-binding site [nucleotide binding]; DNA binding site 443218008555 FCD domain; Region: FCD; pfam07729 443218008556 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218008557 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 443218008558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008559 DNA-binding site [nucleotide binding]; DNA binding site 443218008560 FCD domain; Region: FCD; pfam07729 443218008561 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 443218008562 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218008563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008564 DNA-binding site [nucleotide binding]; DNA binding site 443218008565 FCD domain; Region: FCD; pfam07729 443218008566 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443218008567 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218008568 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218008569 catalytic residue [active] 443218008570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218008571 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443218008572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008573 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218008574 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443218008575 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443218008576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218008577 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443218008578 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443218008579 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443218008580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218008581 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 443218008582 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 443218008583 CGNR zinc finger; Region: zf-CGNR; pfam11706 443218008584 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218008585 HTH domain; Region: HTH_11; pfam08279 443218008586 WYL domain; Region: WYL; pfam13280 443218008587 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218008588 homotrimer interaction site [polypeptide binding]; other site 443218008589 putative active site [active] 443218008590 Protein of unknown function, DUF488; Region: DUF488; pfam04343 443218008591 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218008592 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 443218008593 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 443218008594 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218008595 acyl-activating enzyme (AAE) consensus motif; other site 443218008596 AMP binding site [chemical binding]; other site 443218008597 active site 443218008598 CoA binding site [chemical binding]; other site 443218008599 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443218008600 Short C-terminal domain; Region: SHOCT; pfam09851 443218008601 glutaminase; Provisional; Region: PRK00971 443218008602 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 443218008603 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218008604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218008605 Walker A/P-loop; other site 443218008606 ATP binding site [chemical binding]; other site 443218008607 Q-loop/lid; other site 443218008608 ABC transporter signature motif; other site 443218008609 Walker B; other site 443218008610 D-loop; other site 443218008611 H-loop/switch region; other site 443218008612 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443218008613 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443218008614 Pirin-related protein [General function prediction only]; Region: COG1741 443218008615 Pirin; Region: Pirin; pfam02678 443218008616 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443218008617 Pirin-related protein [General function prediction only]; Region: COG1741 443218008618 Pirin; Region: Pirin; pfam02678 443218008619 Predicted acetyltransferase [General function prediction only]; Region: COG2388 443218008620 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443218008621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218008622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008623 homodimer interface [polypeptide binding]; other site 443218008624 catalytic residue [active] 443218008625 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 443218008626 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 443218008627 [4Fe-4S] binding site [ion binding]; other site 443218008628 molybdopterin cofactor binding site; other site 443218008629 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 443218008630 molybdopterin cofactor binding site; other site 443218008631 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 443218008632 Flavodoxin; Region: Flavodoxin_1; pfam00258 443218008633 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 443218008634 FAD binding pocket [chemical binding]; other site 443218008635 FAD binding motif [chemical binding]; other site 443218008636 catalytic residues [active] 443218008637 NAD binding pocket [chemical binding]; other site 443218008638 phosphate binding motif [ion binding]; other site 443218008639 beta-alpha-beta structure motif; other site 443218008640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008641 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218008642 active site 443218008643 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218008644 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 443218008645 putative di-iron ligands [ion binding]; other site 443218008646 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218008647 Predicted membrane protein [Function unknown]; Region: COG2311 443218008648 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218008649 Protein of unknown function (DUF418); Region: DUF418; pfam04235 443218008650 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443218008651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008652 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443218008653 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443218008654 CopC domain; Region: CopC; pfam04234 443218008655 Copper resistance protein D; Region: CopD; pfam05425 443218008656 YtkA-like; Region: YtkA; pfam13115 443218008657 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 443218008658 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218008659 TIGR03086 family protein; Region: TIGR03086 443218008660 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218008661 MarR family; Region: MarR_2; cl17246 443218008662 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218008663 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218008664 siderophore binding site; other site 443218008665 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218008666 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218008667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218008668 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218008669 Walker A/P-loop; other site 443218008670 ATP binding site [chemical binding]; other site 443218008671 Q-loop/lid; other site 443218008672 ABC transporter signature motif; other site 443218008673 Walker B; other site 443218008674 D-loop; other site 443218008675 H-loop/switch region; other site 443218008676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008677 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218008678 NAD(P) binding site [chemical binding]; other site 443218008679 active site 443218008680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008681 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218008682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218008684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008685 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218008686 short chain dehydrogenase; Provisional; Region: PRK08278 443218008687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008688 NAD(P) binding site [chemical binding]; other site 443218008689 active site 443218008690 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 443218008691 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218008692 putative di-iron ligands [ion binding]; other site 443218008693 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218008694 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218008695 FAD binding pocket [chemical binding]; other site 443218008696 FAD binding motif [chemical binding]; other site 443218008697 phosphate binding motif [ion binding]; other site 443218008698 beta-alpha-beta structure motif; other site 443218008699 NAD(p) ribose binding residues [chemical binding]; other site 443218008700 NAD binding pocket [chemical binding]; other site 443218008701 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218008702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218008703 catalytic loop [active] 443218008704 iron binding site [ion binding]; other site 443218008705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218008706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008707 enoyl-CoA hydratase; Provisional; Region: PRK06688 443218008708 substrate binding site [chemical binding]; other site 443218008709 oxyanion hole (OAH) forming residues; other site 443218008710 trimer interface [polypeptide binding]; other site 443218008711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218008712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218008713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218008715 active site 443218008716 phosphorylation site [posttranslational modification] 443218008717 intermolecular recognition site; other site 443218008718 dimerization interface [polypeptide binding]; other site 443218008719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008720 DNA binding residues [nucleotide binding] 443218008721 dimerization interface [polypeptide binding]; other site 443218008722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218008723 Histidine kinase; Region: HisKA_3; pfam07730 443218008724 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218008725 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218008726 nudix motif; other site 443218008727 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218008728 META domain; Region: META; pfam03724 443218008729 META domain; Region: META; pfam03724 443218008730 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218008731 TIGR03086 family protein; Region: TIGR03086 443218008732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218008734 active site 443218008735 phosphorylation site [posttranslational modification] 443218008736 intermolecular recognition site; other site 443218008737 dimerization interface [polypeptide binding]; other site 443218008738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008739 DNA binding residues [nucleotide binding] 443218008740 dimerization interface [polypeptide binding]; other site 443218008741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218008742 Histidine kinase; Region: HisKA_3; pfam07730 443218008743 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443218008744 ATP binding site [chemical binding]; other site 443218008745 Mg2+ binding site [ion binding]; other site 443218008746 G-X-G motif; other site 443218008747 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218008748 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218008749 Walker A/P-loop; other site 443218008750 ATP binding site [chemical binding]; other site 443218008751 Q-loop/lid; other site 443218008752 ABC transporter signature motif; other site 443218008753 Walker B; other site 443218008754 D-loop; other site 443218008755 H-loop/switch region; other site 443218008756 YceI-like domain; Region: YceI; pfam04264 443218008757 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443218008758 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 443218008759 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 443218008760 putative FMN binding site [chemical binding]; other site 443218008761 NADPH bind site [chemical binding]; other site 443218008762 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 443218008763 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443218008764 catalytic triad [active] 443218008765 Domain of unknown function (DUF309); Region: DUF309; pfam03745 443218008766 Fructosamine kinase; Region: Fructosamin_kin; cl17579 443218008767 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 443218008768 putative FMN binding site [chemical binding]; other site 443218008769 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443218008770 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443218008771 putative dimer interface [polypeptide binding]; other site 443218008772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 443218008773 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 443218008774 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 443218008775 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 443218008776 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443218008777 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 443218008778 SCP-2 sterol transfer family; Region: SCP2; pfam02036 443218008779 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 443218008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008781 S-adenosylmethionine binding site [chemical binding]; other site 443218008782 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 443218008783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008784 S-adenosylmethionine binding site [chemical binding]; other site 443218008785 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 443218008786 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443218008787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218008788 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218008789 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 443218008790 nucleophilic elbow; other site 443218008791 catalytic triad; other site 443218008792 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218008793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218008794 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218008795 CoenzymeA binding site [chemical binding]; other site 443218008796 subunit interaction site [polypeptide binding]; other site 443218008797 PHB binding site; other site 443218008798 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 443218008799 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443218008800 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218008801 dimer interface [polypeptide binding]; other site 443218008802 putative PBP binding regions; other site 443218008803 ABC-ATPase subunit interface; other site 443218008804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218008805 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 443218008806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218008807 ABC-ATPase subunit interface; other site 443218008808 dimer interface [polypeptide binding]; other site 443218008809 putative PBP binding regions; other site 443218008810 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218008811 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218008812 Walker A/P-loop; other site 443218008813 ATP binding site [chemical binding]; other site 443218008814 Q-loop/lid; other site 443218008815 ABC transporter signature motif; other site 443218008816 Walker B; other site 443218008817 D-loop; other site 443218008818 H-loop/switch region; other site 443218008819 Penicillinase repressor; Region: Pencillinase_R; pfam03965 443218008820 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 443218008821 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443218008822 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443218008823 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443218008824 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443218008825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218008826 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443218008827 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443218008828 active site 443218008829 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218008830 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218008831 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218008832 Transporter associated domain; Region: CorC_HlyC; smart01091 443218008833 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218008834 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218008835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218008836 malate synthase G; Provisional; Region: PRK02999 443218008837 active site 443218008838 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443218008839 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443218008840 putative active site [active] 443218008841 putative metal binding site [ion binding]; other site 443218008842 glycine dehydrogenase; Provisional; Region: PRK05367 443218008843 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443218008844 tetramer interface [polypeptide binding]; other site 443218008845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008846 catalytic residue [active] 443218008847 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443218008848 tetramer interface [polypeptide binding]; other site 443218008849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008850 catalytic residue [active] 443218008851 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 443218008852 DNA binding residues [nucleotide binding] 443218008853 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218008854 putative dimer interface [polypeptide binding]; other site 443218008855 Bifunctional nuclease; Region: DNase-RNase; pfam02577 443218008856 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443218008857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218008858 DNA binding residues [nucleotide binding] 443218008859 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 443218008860 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443218008861 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218008862 phosphopeptide binding site; other site 443218008863 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443218008864 lipoyl attachment site [posttranslational modification]; other site 443218008865 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218008866 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 443218008867 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218008868 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443218008869 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443218008870 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443218008871 Walker A/P-loop; other site 443218008872 ATP binding site [chemical binding]; other site 443218008873 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 443218008874 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443218008875 ABC transporter signature motif; other site 443218008876 Walker B; other site 443218008877 D-loop; other site 443218008878 H-loop/switch region; other site 443218008879 acylphosphatase; Provisional; Region: PRK14422 443218008880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008881 putative substrate translocation pore; other site 443218008882 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443218008883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218008884 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218008885 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218008886 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218008887 putative NAD(P) binding site [chemical binding]; other site 443218008888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218008890 short chain dehydrogenase; Validated; Region: PRK08264 443218008891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008892 NAD(P) binding site [chemical binding]; other site 443218008893 active site 443218008894 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443218008895 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443218008896 DNA binding site [nucleotide binding] 443218008897 catalytic residue [active] 443218008898 H2TH interface [polypeptide binding]; other site 443218008899 putative catalytic residues [active] 443218008900 turnover-facilitating residue; other site 443218008901 intercalation triad [nucleotide binding]; other site 443218008902 8OG recognition residue [nucleotide binding]; other site 443218008903 putative reading head residues; other site 443218008904 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218008905 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218008906 ribonuclease III; Reviewed; Region: rnc; PRK00102 443218008907 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443218008908 dimerization interface [polypeptide binding]; other site 443218008909 active site 443218008910 metal binding site [ion binding]; metal-binding site 443218008911 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443218008912 dsRNA binding site [nucleotide binding]; other site 443218008913 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 443218008914 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443218008915 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443218008916 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443218008917 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443218008918 active site 443218008919 (T/H)XGH motif; other site 443218008920 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 443218008921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008922 S-adenosylmethionine binding site [chemical binding]; other site 443218008923 pyruvate carboxylase; Reviewed; Region: PRK12999 443218008924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218008925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218008926 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443218008927 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443218008928 active site 443218008929 catalytic residues [active] 443218008930 metal binding site [ion binding]; metal-binding site 443218008931 homodimer binding site [polypeptide binding]; other site 443218008932 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218008933 carboxyltransferase (CT) interaction site; other site 443218008934 biotinylation site [posttranslational modification]; other site 443218008935 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 443218008936 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443218008937 generic binding surface II; other site 443218008938 ssDNA binding site; other site 443218008939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218008940 ATP binding site [chemical binding]; other site 443218008941 putative Mg++ binding site [ion binding]; other site 443218008942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218008943 nucleotide binding region [chemical binding]; other site 443218008944 ATP-binding site [chemical binding]; other site 443218008945 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 443218008946 DAK2 domain; Region: Dak2; pfam02734 443218008947 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443218008948 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443218008949 ligand binding site [chemical binding]; other site 443218008950 active site 443218008951 UGI interface [polypeptide binding]; other site 443218008952 catalytic site [active] 443218008953 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443218008954 putative active site [active] 443218008955 putative catalytic site [active] 443218008956 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218008957 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443218008958 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 443218008959 acyl-activating enzyme (AAE) consensus motif; other site 443218008960 putative AMP binding site [chemical binding]; other site 443218008961 putative active site [active] 443218008962 putative CoA binding site [chemical binding]; other site 443218008963 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 443218008964 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 443218008965 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 443218008966 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218008967 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008968 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218008969 FAD binding site [chemical binding]; other site 443218008970 homotetramer interface [polypeptide binding]; other site 443218008971 substrate binding pocket [chemical binding]; other site 443218008972 catalytic base [active] 443218008973 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218008974 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218008975 putative di-iron ligands [ion binding]; other site 443218008976 thiamine monophosphate kinase; Provisional; Region: PRK05731 443218008977 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443218008978 ATP binding site [chemical binding]; other site 443218008979 dimerization interface [polypeptide binding]; other site 443218008980 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443218008981 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443218008982 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443218008983 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 443218008984 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443218008985 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443218008986 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443218008987 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 443218008988 polyphosphate kinase; Provisional; Region: PRK05443 443218008989 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443218008990 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443218008991 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443218008992 putative domain interface [polypeptide binding]; other site 443218008993 putative active site [active] 443218008994 catalytic site [active] 443218008995 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443218008996 putative active site [active] 443218008997 catalytic site [active] 443218008998 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443218008999 active site 443218009000 Ap6A binding site [chemical binding]; other site 443218009001 nudix motif; other site 443218009002 metal binding site [ion binding]; metal-binding site 443218009003 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218009004 catalytic core [active] 443218009005 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443218009006 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443218009007 substrate binding site [chemical binding]; other site 443218009008 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443218009009 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443218009010 substrate binding site [chemical binding]; other site 443218009011 ligand binding site [chemical binding]; other site 443218009012 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218009013 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443218009014 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218009015 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443218009016 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443218009017 HIGH motif; other site 443218009018 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443218009019 active site 443218009020 KMSKS motif; other site 443218009021 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443218009022 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443218009023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443218009024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218009025 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 443218009026 tartrate dehydrogenase; Region: TTC; TIGR02089 443218009027 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443218009028 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443218009029 ligand binding site [chemical binding]; other site 443218009030 NAD binding site [chemical binding]; other site 443218009031 dimerization interface [polypeptide binding]; other site 443218009032 catalytic site [active] 443218009033 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443218009034 putative L-serine binding site [chemical binding]; other site 443218009035 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443218009036 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443218009037 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443218009038 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443218009039 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443218009040 dimer interface [polypeptide binding]; other site 443218009041 putative valine binding site [chemical binding]; other site 443218009042 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443218009043 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443218009044 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218009045 PYR/PP interface [polypeptide binding]; other site 443218009046 dimer interface [polypeptide binding]; other site 443218009047 TPP binding site [chemical binding]; other site 443218009048 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443218009049 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443218009050 TPP-binding site [chemical binding]; other site 443218009051 dimer interface [polypeptide binding]; other site 443218009052 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443218009053 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 443218009054 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 443218009055 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443218009056 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443218009057 GatB domain; Region: GatB_Yqey; smart00845 443218009058 6-phosphofructokinase; Provisional; Region: PRK03202 443218009059 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443218009060 active site 443218009061 ADP/pyrophosphate binding site [chemical binding]; other site 443218009062 dimerization interface [polypeptide binding]; other site 443218009063 allosteric effector site; other site 443218009064 fructose-1,6-bisphosphate binding site; other site 443218009065 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443218009066 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443218009067 transmembrane helices; other site 443218009068 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443218009069 PAS domain; Region: PAS; smart00091 443218009070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218009071 ATP binding site [chemical binding]; other site 443218009072 Mg2+ binding site [ion binding]; other site 443218009073 G-X-G motif; other site 443218009074 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443218009075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218009076 active site 443218009077 phosphorylation site [posttranslational modification] 443218009078 intermolecular recognition site; other site 443218009079 dimerization interface [polypeptide binding]; other site 443218009080 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443218009081 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218009082 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443218009083 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 443218009084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218009086 Cytochrome P450; Region: p450; cl12078 443218009087 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218009088 putative acetyltransferase; Provisional; Region: PRK03624 443218009089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218009090 Coenzyme A binding pocket [chemical binding]; other site 443218009091 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443218009092 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443218009093 nucleotide binding pocket [chemical binding]; other site 443218009094 K-X-D-G motif; other site 443218009095 catalytic site [active] 443218009096 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443218009097 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443218009098 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443218009099 Dimer interface [polypeptide binding]; other site 443218009100 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 443218009101 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443218009102 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443218009103 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443218009104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218009105 catalytic residue [active] 443218009106 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218009107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218009108 putative acyl-acceptor binding pocket; other site 443218009109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 443218009110 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443218009111 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443218009112 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443218009113 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443218009114 Ligand binding site [chemical binding]; other site 443218009115 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443218009116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009117 S-adenosylmethionine binding site [chemical binding]; other site 443218009118 Uncharacterized conserved protein [Function unknown]; Region: COG1543 443218009119 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443218009120 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 443218009121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218009122 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218009123 short chain dehydrogenase; Provisional; Region: PRK07825 443218009124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218009125 NAD(P) binding site [chemical binding]; other site 443218009126 active site 443218009127 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443218009128 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443218009129 trimer interface [polypeptide binding]; other site 443218009130 active site 443218009131 substrate binding site [chemical binding]; other site 443218009132 CoA binding site [chemical binding]; other site 443218009133 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 443218009134 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443218009135 hexamer interface [polypeptide binding]; other site 443218009136 ligand binding site [chemical binding]; other site 443218009137 putative active site [active] 443218009138 NAD(P) binding site [chemical binding]; other site 443218009139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009140 S-adenosylmethionine binding site [chemical binding]; other site 443218009141 enoyl-CoA hydratase; Provisional; Region: PRK05862 443218009142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009143 substrate binding site [chemical binding]; other site 443218009144 oxyanion hole (OAH) forming residues; other site 443218009145 trimer interface [polypeptide binding]; other site 443218009146 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218009147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218009148 Walker A/P-loop; other site 443218009149 ATP binding site [chemical binding]; other site 443218009150 Q-loop/lid; other site 443218009151 ABC transporter signature motif; other site 443218009152 Walker B; other site 443218009153 D-loop; other site 443218009154 H-loop/switch region; other site 443218009155 glycogen branching enzyme; Provisional; Region: PRK05402 443218009156 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443218009157 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443218009158 active site 443218009159 catalytic site [active] 443218009160 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443218009161 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443218009162 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443218009163 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 443218009164 Domain of unknown function DUF77; Region: DUF77; pfam01910 443218009165 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443218009166 putative acyltransferase; Provisional; Region: PRK05790 443218009167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218009168 dimer interface [polypeptide binding]; other site 443218009169 active site 443218009170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009171 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443218009172 dimer interface [polypeptide binding]; other site 443218009173 substrate binding site [chemical binding]; other site 443218009174 metal binding site [ion binding]; metal-binding site 443218009175 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443218009176 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218009177 TPP-binding site [chemical binding]; other site 443218009178 dimer interface [polypeptide binding]; other site 443218009179 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218009180 PYR/PP interface [polypeptide binding]; other site 443218009181 dimer interface [polypeptide binding]; other site 443218009182 TPP binding site [chemical binding]; other site 443218009183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218009184 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 443218009185 hypothetical protein; Provisional; Region: PRK03298 443218009186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218009187 dimerization interface [polypeptide binding]; other site 443218009188 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218009189 cyclase homology domain; Region: CHD; cd07302 443218009190 nucleotidyl binding site; other site 443218009191 metal binding site [ion binding]; metal-binding site 443218009192 dimer interface [polypeptide binding]; other site 443218009193 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218009194 RibD C-terminal domain; Region: RibD_C; cl17279 443218009195 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443218009196 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443218009197 hinge; other site 443218009198 active site 443218009199 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 443218009200 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 443218009201 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443218009202 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 443218009203 gamma subunit interface [polypeptide binding]; other site 443218009204 LBP interface [polypeptide binding]; other site 443218009205 epsilon subunit interface [polypeptide binding]; other site 443218009206 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443218009207 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443218009208 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443218009209 alpha subunit interaction interface [polypeptide binding]; other site 443218009210 Walker A motif; other site 443218009211 ATP binding site [chemical binding]; other site 443218009212 Walker B motif; other site 443218009213 inhibitor binding site; inhibition site 443218009214 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443218009215 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443218009216 core domain interface [polypeptide binding]; other site 443218009217 delta subunit interface [polypeptide binding]; other site 443218009218 epsilon subunit interface [polypeptide binding]; other site 443218009219 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443218009220 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443218009221 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 443218009222 beta subunit interaction interface [polypeptide binding]; other site 443218009223 Walker A motif; other site 443218009224 ATP binding site [chemical binding]; other site 443218009225 Walker B motif; other site 443218009226 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443218009227 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 443218009228 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 443218009229 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443218009230 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443218009231 ATP synthase subunit C; Region: ATP-synt_C; cl00466 443218009232 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443218009233 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443218009234 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443218009235 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443218009236 Mg++ binding site [ion binding]; other site 443218009237 putative catalytic motif [active] 443218009238 substrate binding site [chemical binding]; other site 443218009239 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218009240 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218009241 dimer interface [polypeptide binding]; other site 443218009242 active site 443218009243 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218009244 folate binding site [chemical binding]; other site 443218009245 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443218009246 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443218009247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009248 S-adenosylmethionine binding site [chemical binding]; other site 443218009249 peptide chain release factor 1; Validated; Region: prfA; PRK00591 443218009250 PCRF domain; Region: PCRF; pfam03462 443218009251 RF-1 domain; Region: RF-1; pfam00472 443218009252 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 443218009253 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 443218009254 transcription termination factor Rho; Provisional; Region: PRK12608 443218009255 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218009256 RNA binding site [nucleotide binding]; other site 443218009257 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443218009258 multimer interface [polypeptide binding]; other site 443218009259 Walker A motif; other site 443218009260 ATP binding site [chemical binding]; other site 443218009261 Walker B motif; other site 443218009262 homoserine kinase; Provisional; Region: PRK01212 443218009263 threonine synthase; Reviewed; Region: PRK06721 443218009264 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443218009265 homodimer interface [polypeptide binding]; other site 443218009266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009267 catalytic residue [active] 443218009268 homoserine dehydrogenase; Provisional; Region: PRK06349 443218009269 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443218009270 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443218009271 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443218009272 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443218009273 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443218009274 active site 443218009275 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218009276 substrate binding site [chemical binding]; other site 443218009277 catalytic residues [active] 443218009278 dimer interface [polypeptide binding]; other site 443218009279 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443218009280 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443218009281 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443218009282 active site 443218009283 HIGH motif; other site 443218009284 KMSK motif region; other site 443218009285 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 443218009286 tRNA binding surface [nucleotide binding]; other site 443218009287 anticodon binding site; other site 443218009288 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 443218009289 Domain of unknown function (DUF305); Region: DUF305; pfam03713 443218009290 HEAT repeats; Region: HEAT_2; pfam13646 443218009291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009292 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 443218009293 Lipase (class 2); Region: Lipase_2; pfam01674 443218009294 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218009295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009297 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443218009298 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 443218009299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009300 active site 443218009301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218009303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218009304 dimerization interface [polypeptide binding]; other site 443218009305 DNA binding residues [nucleotide binding] 443218009306 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218009307 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218009308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218009309 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443218009310 acyl-activating enzyme (AAE) consensus motif; other site 443218009311 putative AMP binding site [chemical binding]; other site 443218009312 putative active site [active] 443218009313 putative CoA binding site [chemical binding]; other site 443218009314 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218009315 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009316 substrate binding site [chemical binding]; other site 443218009317 oxyanion hole (OAH) forming residues; other site 443218009318 trimer interface [polypeptide binding]; other site 443218009319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218009320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218009321 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443218009322 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443218009323 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218009324 intersubunit interface [polypeptide binding]; other site 443218009325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218009326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218009327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218009328 putative substrate translocation pore; other site 443218009329 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443218009330 HIT family signature motif; other site 443218009331 catalytic residue [active] 443218009332 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 443218009333 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218009334 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 443218009335 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 443218009336 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 443218009337 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443218009338 conserved cys residue [active] 443218009339 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 443218009340 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443218009341 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218009342 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 443218009343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218009344 ATP binding site [chemical binding]; other site 443218009345 Mg++ binding site [ion binding]; other site 443218009346 motif III; other site 443218009347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009348 nucleotide binding region [chemical binding]; other site 443218009349 ATP-binding site [chemical binding]; other site 443218009350 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 443218009351 putative RNA binding site [nucleotide binding]; other site 443218009352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218009353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443218009354 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443218009355 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218009356 nucleophile elbow; other site 443218009357 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218009358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009359 substrate binding site [chemical binding]; other site 443218009360 oxyanion hole (OAH) forming residues; other site 443218009361 trimer interface [polypeptide binding]; other site 443218009362 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218009363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009364 active site 443218009365 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 443218009366 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 443218009367 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 443218009368 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 443218009369 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 443218009370 putative dimer interface [polypeptide binding]; other site 443218009371 N-terminal domain interface [polypeptide binding]; other site 443218009372 putative substrate binding pocket (H-site) [chemical binding]; other site 443218009373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218009374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218009375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218009376 Walker A/P-loop; other site 443218009377 ATP binding site [chemical binding]; other site 443218009378 Q-loop/lid; other site 443218009379 ABC transporter signature motif; other site 443218009380 Walker B; other site 443218009381 D-loop; other site 443218009382 H-loop/switch region; other site 443218009383 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218009384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218009385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218009386 Walker A/P-loop; other site 443218009387 ATP binding site [chemical binding]; other site 443218009388 Q-loop/lid; other site 443218009389 ABC transporter signature motif; other site 443218009390 Walker B; other site 443218009391 D-loop; other site 443218009392 H-loop/switch region; other site 443218009393 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443218009394 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443218009395 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443218009396 TPP-binding site [chemical binding]; other site 443218009397 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443218009398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009400 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218009401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218009402 short chain dehydrogenase; Provisional; Region: PRK07832 443218009403 classical (c) SDRs; Region: SDR_c; cd05233 443218009404 NAD(P) binding site [chemical binding]; other site 443218009405 active site 443218009406 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 443218009407 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443218009408 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 443218009409 NAD(P) binding pocket [chemical binding]; other site 443218009410 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 443218009411 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443218009412 active site 443218009413 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443218009414 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 443218009415 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443218009416 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218009417 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218009418 Domain of unknown function DUF59; Region: DUF59; pfam01883 443218009419 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443218009420 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 443218009421 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218009422 sec-independent translocase; Provisional; Region: PRK03100 443218009423 Putative zinc-finger; Region: zf-HC2; pfam13490 443218009424 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 443218009425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218009426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218009427 DNA binding residues [nucleotide binding] 443218009428 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443218009429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009430 S-adenosylmethionine binding site [chemical binding]; other site 443218009431 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443218009432 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443218009433 ligand binding site; other site 443218009434 oligomer interface; other site 443218009435 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443218009436 sulfate 1 binding site; other site 443218009437 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 443218009438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009439 S-adenosylmethionine binding site [chemical binding]; other site 443218009440 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443218009441 interface (dimer of trimers) [polypeptide binding]; other site 443218009442 Substrate-binding/catalytic site; other site 443218009443 Zn-binding sites [ion binding]; other site 443218009444 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 443218009445 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 443218009446 DivIVA domain; Region: DivI1A_domain; TIGR03544 443218009447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443218009448 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443218009449 Ligand binding site; other site 443218009450 Putative Catalytic site; other site 443218009451 DXD motif; other site 443218009452 dihydropteroate synthase; Region: DHPS; TIGR01496 443218009453 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218009454 substrate binding pocket [chemical binding]; other site 443218009455 dimer interface [polypeptide binding]; other site 443218009456 inhibitor binding site; inhibition site 443218009457 Ion channel; Region: Ion_trans_2; pfam07885 443218009458 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443218009459 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 443218009460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218009461 MarR family; Region: MarR_2; pfam12802 443218009462 MMPL family; Region: MMPL; pfam03176 443218009463 MMPL family; Region: MMPL; pfam03176 443218009464 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 443218009465 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443218009466 metal binding site [ion binding]; metal-binding site 443218009467 putative dimer interface [polypeptide binding]; other site 443218009468 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443218009469 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443218009470 putative trimer interface [polypeptide binding]; other site 443218009471 putative CoA binding site [chemical binding]; other site 443218009472 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443218009473 acyl-CoA synthetase; Validated; Region: PRK07787 443218009474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218009475 acyl-activating enzyme (AAE) consensus motif; other site 443218009476 AMP binding site [chemical binding]; other site 443218009477 active site 443218009478 CoA binding site [chemical binding]; other site 443218009479 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 443218009480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218009481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009482 homodimer interface [polypeptide binding]; other site 443218009483 catalytic residue [active] 443218009484 Ferredoxin [Energy production and conversion]; Region: COG1146 443218009485 4Fe-4S binding domain; Region: Fer4; pfam00037 443218009486 FO synthase; Reviewed; Region: fbiC; PRK09234 443218009487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218009488 FeS/SAM binding site; other site 443218009489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218009490 FeS/SAM binding site; other site 443218009491 Uncharacterized conserved protein [Function unknown]; Region: COG3402 443218009492 Bacterial PH domain; Region: DUF304; pfam03703 443218009493 Bacterial PH domain; Region: DUF304; pfam03703 443218009494 Bacterial PH domain; Region: DUF304; cl01348 443218009495 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 443218009496 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443218009497 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443218009498 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443218009499 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443218009500 G1 box; other site 443218009501 putative GEF interaction site [polypeptide binding]; other site 443218009502 GTP/Mg2+ binding site [chemical binding]; other site 443218009503 Switch I region; other site 443218009504 G2 box; other site 443218009505 G3 box; other site 443218009506 Switch II region; other site 443218009507 G4 box; other site 443218009508 G5 box; other site 443218009509 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443218009510 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443218009511 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443218009512 active site 443218009513 8-oxo-dGMP binding site [chemical binding]; other site 443218009514 nudix motif; other site 443218009515 metal binding site [ion binding]; metal-binding site 443218009516 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218009517 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 443218009518 Walker A/P-loop; other site 443218009519 ATP binding site [chemical binding]; other site 443218009520 Q-loop/lid; other site 443218009521 ABC transporter signature motif; other site 443218009522 Walker B; other site 443218009523 D-loop; other site 443218009524 H-loop/switch region; other site 443218009525 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 443218009526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218009527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218009528 dimer interface [polypeptide binding]; other site 443218009529 conserved gate region; other site 443218009530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218009531 ABC-ATPase subunit interface; other site 443218009532 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 443218009533 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443218009534 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 443218009535 aromatic arch; other site 443218009536 DCoH dimer interaction site [polypeptide binding]; other site 443218009537 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 443218009538 DCoH tetramer interaction site [polypeptide binding]; other site 443218009539 substrate binding site [chemical binding]; other site 443218009540 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 443218009541 Na2 binding site [ion binding]; other site 443218009542 putative substrate binding site 1 [chemical binding]; other site 443218009543 Na binding site 1 [ion binding]; other site 443218009544 putative substrate binding site 2 [chemical binding]; other site 443218009545 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218009546 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218009547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218009548 catalytic residue [active] 443218009549 mannosyltransferase; Provisional; Region: pimE; PRK13375 443218009550 NAD-dependent deacetylase; Provisional; Region: PRK00481 443218009551 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 443218009552 NAD+ binding site [chemical binding]; other site 443218009553 substrate binding site [chemical binding]; other site 443218009554 Zn binding site [ion binding]; other site 443218009555 PspC domain; Region: PspC; pfam04024 443218009556 DNA polymerase IV; Validated; Region: PRK03352 443218009557 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218009558 active site 443218009559 DNA binding site [nucleotide binding] 443218009560 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218009561 GTP-binding protein YchF; Reviewed; Region: PRK09601 443218009562 YchF GTPase; Region: YchF; cd01900 443218009563 G1 box; other site 443218009564 GTP/Mg2+ binding site [chemical binding]; other site 443218009565 Switch I region; other site 443218009566 G2 box; other site 443218009567 Switch II region; other site 443218009568 G3 box; other site 443218009569 G4 box; other site 443218009570 G5 box; other site 443218009571 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 443218009572 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 443218009573 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 443218009574 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443218009575 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443218009576 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443218009577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218009578 Walker A/P-loop; other site 443218009579 ATP binding site [chemical binding]; other site 443218009580 Q-loop/lid; other site 443218009581 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 443218009582 ABC transporter signature motif; other site 443218009583 Walker B; other site 443218009584 D-loop; other site 443218009585 H-loop/switch region; other site 443218009586 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 443218009587 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443218009588 active site 443218009589 metal binding site [ion binding]; metal-binding site 443218009590 DNA binding site [nucleotide binding] 443218009591 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 443218009592 RmuC family; Region: RmuC; pfam02646 443218009593 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443218009594 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443218009595 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 443218009596 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443218009597 generic binding surface II; other site 443218009598 generic binding surface I; other site 443218009599 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 443218009600 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443218009601 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443218009602 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 443218009603 putative active site [active] 443218009604 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443218009605 Class II fumarases; Region: Fumarase_classII; cd01362 443218009606 active site 443218009607 tetramer interface [polypeptide binding]; other site 443218009608 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443218009609 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443218009610 putative active site [active] 443218009611 PhoH-like protein; Region: PhoH; pfam02562 443218009612 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218009613 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218009614 dimer interface [polypeptide binding]; other site 443218009615 active site 443218009616 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218009617 folate binding site [chemical binding]; other site 443218009618 pantothenate kinase; Provisional; Region: PRK05439 443218009619 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 443218009620 ATP-binding site [chemical binding]; other site 443218009621 CoA-binding site [chemical binding]; other site 443218009622 Mg2+-binding site [ion binding]; other site 443218009623 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443218009624 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443218009625 catalytic residue [active] 443218009626 putative FPP diphosphate binding site; other site 443218009627 putative FPP binding hydrophobic cleft; other site 443218009628 dimer interface [polypeptide binding]; other site 443218009629 putative IPP diphosphate binding site; other site 443218009630 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443218009631 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 443218009632 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218009633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009634 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218009635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218009636 Walker A/P-loop; other site 443218009637 ATP binding site [chemical binding]; other site 443218009638 Q-loop/lid; other site 443218009639 ABC transporter signature motif; other site 443218009640 Walker B; other site 443218009641 D-loop; other site 443218009642 H-loop/switch region; other site 443218009643 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443218009644 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443218009645 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 443218009646 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443218009647 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443218009648 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443218009649 catalytic residues [active] 443218009650 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 443218009651 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443218009652 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443218009653 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443218009654 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443218009655 Predicted flavoprotein [General function prediction only]; Region: COG0431 443218009656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218009657 cystathionine gamma-synthase; Provisional; Region: PRK07811 443218009658 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218009659 homodimer interface [polypeptide binding]; other site 443218009660 substrate-cofactor binding pocket; other site 443218009661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009662 catalytic residue [active] 443218009663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009665 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 443218009666 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009667 active site 443218009668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009669 enoyl-CoA hydratase; Provisional; Region: PRK07799 443218009670 substrate binding site [chemical binding]; other site 443218009671 oxyanion hole (OAH) forming residues; other site 443218009672 trimer interface [polypeptide binding]; other site 443218009673 enoyl-CoA hydratase; Provisional; Region: PRK12478 443218009674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009675 substrate binding site [chemical binding]; other site 443218009676 oxyanion hole (OAH) forming residues; other site 443218009677 trimer interface [polypeptide binding]; other site 443218009678 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 443218009679 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 443218009680 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443218009681 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218009682 TPP-binding site [chemical binding]; other site 443218009683 dimer interface [polypeptide binding]; other site 443218009684 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218009685 PYR/PP interface [polypeptide binding]; other site 443218009686 dimer interface [polypeptide binding]; other site 443218009687 TPP binding site [chemical binding]; other site 443218009688 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218009689 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443218009690 putative active site [active] 443218009691 transaldolase; Provisional; Region: PRK03903 443218009692 catalytic residue [active] 443218009693 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218009694 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443218009695 putative [Fe4-S4] binding site [ion binding]; other site 443218009696 putative molybdopterin cofactor binding site [chemical binding]; other site 443218009697 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218009698 putative molybdopterin cofactor binding site; other site 443218009699 FAD binding domain; Region: FAD_binding_4; pfam01565 443218009700 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443218009701 classical (c) SDRs; Region: SDR_c; cd05233 443218009702 NAD(P) binding site [chemical binding]; other site 443218009703 active site 443218009704 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 443218009705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218009707 active site 443218009708 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443218009709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218009710 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218009711 active site residue [active] 443218009712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009713 S-adenosylmethionine binding site [chemical binding]; other site 443218009714 DoxX-like family; Region: DoxX_2; pfam13564 443218009715 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 443218009716 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 443218009717 DNA binding residues [nucleotide binding] 443218009718 dimer interface [polypeptide binding]; other site 443218009719 [2Fe-2S] cluster binding site [ion binding]; other site 443218009720 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443218009721 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443218009722 dimer interface [polypeptide binding]; other site 443218009723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009724 catalytic residue [active] 443218009725 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443218009726 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443218009727 active site 443218009728 catalytic triad [active] 443218009729 oxyanion hole [active] 443218009730 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 443218009731 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218009732 dimer interface [polypeptide binding]; other site 443218009733 active site 443218009734 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218009735 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443218009736 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 443218009737 active site 443218009738 trimer interface [polypeptide binding]; other site 443218009739 allosteric site; other site 443218009740 active site lid [active] 443218009741 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443218009742 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 443218009743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009744 active site 443218009745 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218009746 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218009747 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443218009748 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443218009749 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 443218009750 dimerization domain swap beta strand [polypeptide binding]; other site 443218009751 regulatory protein interface [polypeptide binding]; other site 443218009752 active site 443218009753 regulatory phosphorylation site [posttranslational modification]; other site 443218009754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 443218009755 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 443218009756 active site turn [active] 443218009757 phosphorylation site [posttranslational modification] 443218009758 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 443218009759 HPr interaction site; other site 443218009760 glycerol kinase (GK) interaction site [polypeptide binding]; other site 443218009761 active site 443218009762 phosphorylation site [posttranslational modification] 443218009763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218009764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218009765 active site 443218009766 catalytic tetrad [active] 443218009767 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443218009768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009769 DNA-binding site [nucleotide binding]; DNA binding site 443218009770 UTRA domain; Region: UTRA; pfam07702 443218009771 Bax inhibitor 1 like; Region: BaxI_1; cl17691 443218009772 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 443218009773 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218009774 putative dimer interface [polypeptide binding]; other site 443218009775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009776 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218009777 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443218009778 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443218009779 Uncharacterized conserved protein [Function unknown]; Region: COG1507 443218009780 Septum formation initiator; Region: DivIC; pfam04977 443218009781 enolase; Provisional; Region: eno; PRK00077 443218009782 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443218009783 dimer interface [polypeptide binding]; other site 443218009784 metal binding site [ion binding]; metal-binding site 443218009785 substrate binding pocket [chemical binding]; other site 443218009786 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443218009787 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218009788 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218009789 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 443218009790 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443218009791 homodimer interface [polypeptide binding]; other site 443218009792 metal binding site [ion binding]; metal-binding site 443218009793 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443218009794 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443218009795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218009796 ATP binding site [chemical binding]; other site 443218009797 putative Mg++ binding site [ion binding]; other site 443218009798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009799 nucleotide binding region [chemical binding]; other site 443218009800 ATP-binding site [chemical binding]; other site 443218009801 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443218009802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218009804 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 443218009805 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443218009806 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443218009807 Substrate binding site; other site 443218009808 Mg++ binding site; other site 443218009809 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443218009810 active site 443218009811 substrate binding site [chemical binding]; other site 443218009812 CoA binding site [chemical binding]; other site 443218009813 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443218009814 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443218009815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218009816 active site 443218009817 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 443218009818 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443218009819 5S rRNA interface [nucleotide binding]; other site 443218009820 CTC domain interface [polypeptide binding]; other site 443218009821 L16 interface [polypeptide binding]; other site 443218009822 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443218009823 putative active site [active] 443218009824 catalytic residue [active] 443218009825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 443218009826 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443218009827 acyl-activating enzyme (AAE) consensus motif; other site 443218009828 active site 443218009829 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 443218009830 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 443218009831 G1 box; other site 443218009832 putative GEF interaction site [polypeptide binding]; other site 443218009833 GTP/Mg2+ binding site [chemical binding]; other site 443218009834 Switch I region; other site 443218009835 G2 box; other site 443218009836 G3 box; other site 443218009837 Switch II region; other site 443218009838 G4 box; other site 443218009839 G5 box; other site 443218009840 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443218009841 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443218009842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009843 DNA-binding site [nucleotide binding]; DNA binding site 443218009844 FCD domain; Region: FCD; pfam07729 443218009845 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 443218009846 AAA domain; Region: AAA_33; pfam13671 443218009847 ATP-binding site [chemical binding]; other site 443218009848 Gluconate-6-phosphate binding site [chemical binding]; other site 443218009849 fructuronate transporter; Provisional; Region: PRK10034; cl15264 443218009850 GntP family permease; Region: GntP_permease; pfam02447 443218009851 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443218009852 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218009853 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 443218009854 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218009855 putative dimer interface [polypeptide binding]; other site 443218009856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218009858 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218009859 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 443218009860 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218009861 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218009862 ABC transporter; Region: ABC_tran_2; pfam12848 443218009863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443218009864 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443218009865 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443218009866 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443218009867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009868 S-adenosylmethionine binding site [chemical binding]; other site 443218009869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 443218009870 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443218009871 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443218009872 G5 domain; Region: G5; pfam07501 443218009873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218009874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218009875 catalytic residue [active] 443218009876 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443218009877 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443218009878 active site 443218009879 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 443218009880 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443218009881 active site 443218009882 KMSKS motif; other site 443218009883 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443218009884 tRNA binding surface [nucleotide binding]; other site 443218009885 anticodon binding site; other site 443218009886 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 443218009887 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 443218009888 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218009889 Predicted methyltransferases [General function prediction only]; Region: COG0313 443218009890 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443218009891 putative SAM binding site [chemical binding]; other site 443218009892 putative homodimer interface [polypeptide binding]; other site 443218009893 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443218009894 Predicted membrane protein [Function unknown]; Region: COG2259 443218009895 DoxX-like family; Region: DoxX_2; pfam13564 443218009896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009897 DNA-binding site [nucleotide binding]; DNA binding site 443218009898 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 443218009899 ArsC family; Region: ArsC; pfam03960 443218009900 catalytic residues [active] 443218009901 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218009902 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 443218009903 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 443218009904 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443218009905 BCCT family transporter; Region: BCCT; pfam02028 443218009906 high affinity sulphate transporter 1; Region: sulP; TIGR00815 443218009907 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443218009908 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443218009909 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443218009910 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 443218009911 putative hydrophobic ligand binding site [chemical binding]; other site 443218009912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218009913 Coenzyme A binding pocket [chemical binding]; other site 443218009914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218009915 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 443218009916 ATP binding site [chemical binding]; other site 443218009917 putative Mg++ binding site [ion binding]; other site 443218009918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009919 nucleotide binding region [chemical binding]; other site 443218009920 ATP-binding site [chemical binding]; other site 443218009921 DEAD/H associated; Region: DEAD_assoc; pfam08494 443218009922 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443218009923 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443218009924 putative DNA binding site [nucleotide binding]; other site 443218009925 catalytic residue [active] 443218009926 putative H2TH interface [polypeptide binding]; other site 443218009927 putative catalytic residues [active] 443218009928 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218009929 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218009930 RES domain; Region: RES; cl02411 443218009931 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443218009932 DNA binding site [nucleotide binding] 443218009933 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218009934 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218009935 intersubunit interface [polypeptide binding]; other site 443218009936 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443218009937 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 443218009938 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443218009939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218009940 ABC-ATPase subunit interface; other site 443218009941 dimer interface [polypeptide binding]; other site 443218009942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009943 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 443218009944 active site 443218009945 ChaB; Region: ChaB; pfam06150 443218009946 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 443218009947 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218009948 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443218009949 Walker A/P-loop; other site 443218009950 ATP binding site [chemical binding]; other site 443218009951 Q-loop/lid; other site 443218009952 ABC transporter signature motif; other site 443218009953 Walker B; other site 443218009954 D-loop; other site 443218009955 H-loop/switch region; other site 443218009956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443218009957 FtsX-like permease family; Region: FtsX; pfam02687 443218009958 FtsX-like permease family; Region: FtsX; pfam02687 443218009959 Domain of unknown function DUF302; Region: DUF302; cl01364 443218009960 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443218009961 putative homodimer interface [polypeptide binding]; other site 443218009962 putative homotetramer interface [polypeptide binding]; other site 443218009963 putative allosteric switch controlling residues; other site 443218009964 putative metal binding site [ion binding]; other site 443218009965 putative homodimer-homodimer interface [polypeptide binding]; other site 443218009966 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 443218009967 MarR family; Region: MarR_2; pfam12802 443218009968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218009969 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218009970 Walker A/P-loop; other site 443218009971 ATP binding site [chemical binding]; other site 443218009972 Q-loop/lid; other site 443218009973 ABC transporter signature motif; other site 443218009974 Walker B; other site 443218009975 D-loop; other site 443218009976 H-loop/switch region; other site 443218009977 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443218009978 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 443218009979 short chain dehydrogenase; Provisional; Region: PRK07832 443218009980 classical (c) SDRs; Region: SDR_c; cd05233 443218009981 NAD(P) binding site [chemical binding]; other site 443218009982 active site 443218009983 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 443218009984 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443218009985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443218009986 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443218009987 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443218009988 dimer interface [polypeptide binding]; other site 443218009989 putative functional site; other site 443218009990 putative MPT binding site; other site 443218009991 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 443218009992 active site 443218009993 tetramer interface; other site 443218009994 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443218009995 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 443218009996 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 443218009997 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218009998 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218009999 catalytic residues [active] 443218010000 catalytic nucleophile [active] 443218010001 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218010002 Probable transposase; Region: OrfB_IS605; pfam01385 443218010003 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218010004 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 443218010005 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 443218010006 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443218010007 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443218010008 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 443218010009 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443218010010 MPT binding site; other site 443218010011 trimer interface [polypeptide binding]; other site 443218010012 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218010013 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443218010014 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218010015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218010016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218010017 dimerization interface [polypeptide binding]; other site 443218010018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218010019 dimer interface [polypeptide binding]; other site 443218010020 phosphorylation site [posttranslational modification] 443218010021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010022 ATP binding site [chemical binding]; other site 443218010023 Mg2+ binding site [ion binding]; other site 443218010024 G-X-G motif; other site 443218010025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218010026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010027 active site 443218010028 phosphorylation site [posttranslational modification] 443218010029 intermolecular recognition site; other site 443218010030 dimerization interface [polypeptide binding]; other site 443218010031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218010032 DNA binding site [nucleotide binding] 443218010033 Predicted membrane protein [Function unknown]; Region: COG2860 443218010034 UPF0126 domain; Region: UPF0126; pfam03458 443218010035 UPF0126 domain; Region: UPF0126; pfam03458 443218010036 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 443218010037 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218010038 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443218010039 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443218010040 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 443218010041 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 443218010042 30S ribosomal protein S18; Provisional; Region: PRK13401 443218010043 Predicted permeases [General function prediction only]; Region: COG0679 443218010044 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443218010045 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443218010046 purine monophosphate binding site [chemical binding]; other site 443218010047 dimer interface [polypeptide binding]; other site 443218010048 putative catalytic residues [active] 443218010049 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443218010050 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443218010051 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443218010052 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443218010053 active site 443218010054 substrate binding site [chemical binding]; other site 443218010055 cosubstrate binding site; other site 443218010056 catalytic site [active] 443218010057 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443218010058 CoA binding domain; Region: CoA_binding; smart00881 443218010059 CoA-ligase; Region: Ligase_CoA; pfam00549 443218010060 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443218010061 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443218010062 CoA-ligase; Region: Ligase_CoA; pfam00549 443218010063 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443218010064 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218010065 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443218010066 Part of AAA domain; Region: AAA_19; pfam13245 443218010067 Family description; Region: UvrD_C_2; pfam13538 443218010068 hypothetical protein; Provisional; Region: PRK07857 443218010069 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218010070 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218010071 tetramerization interface [polypeptide binding]; other site 443218010072 NAD(P) binding site [chemical binding]; other site 443218010073 catalytic residues [active] 443218010074 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 443218010075 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443218010076 active site 443218010077 dimer interface [polypeptide binding]; other site 443218010078 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443218010079 dimer interface [polypeptide binding]; other site 443218010080 active site 443218010081 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218010082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218010083 active site 443218010084 ATP binding site [chemical binding]; other site 443218010085 substrate binding site [chemical binding]; other site 443218010086 activation loop (A-loop); other site 443218010087 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 443218010088 active site 443218010089 SAM binding site [chemical binding]; other site 443218010090 homodimer interface [polypeptide binding]; other site 443218010091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010093 Cutinase; Region: Cutinase; pfam01083 443218010094 Cutinase; Region: Cutinase; pfam01083 443218010095 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218010096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218010097 DNA-binding site [nucleotide binding]; DNA binding site 443218010098 FCD domain; Region: FCD; pfam07729 443218010099 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218010100 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218010101 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 443218010102 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443218010103 NAD binding site [chemical binding]; other site 443218010104 ligand binding site [chemical binding]; other site 443218010105 catalytic site [active] 443218010106 putative amidase; Provisional; Region: PRK06169 443218010107 Amidase; Region: Amidase; pfam01425 443218010108 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443218010109 heme-binding site [chemical binding]; other site 443218010110 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218010111 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218010112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010113 active site 443218010114 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218010115 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443218010116 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218010117 Walker A/P-loop; other site 443218010118 ATP binding site [chemical binding]; other site 443218010119 Q-loop/lid; other site 443218010120 ABC transporter signature motif; other site 443218010121 Walker B; other site 443218010122 D-loop; other site 443218010123 H-loop/switch region; other site 443218010124 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218010125 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218010126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010128 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 443218010129 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218010130 inhibitor-cofactor binding pocket; inhibition site 443218010131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218010132 catalytic residue [active] 443218010133 succinic semialdehyde dehydrogenase; Region: PLN02278 443218010134 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218010135 tetramerization interface [polypeptide binding]; other site 443218010136 NAD(P) binding site [chemical binding]; other site 443218010137 catalytic residues [active] 443218010138 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218010139 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218010140 putative di-iron ligands [ion binding]; other site 443218010141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218010142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218010143 substrate binding pocket [chemical binding]; other site 443218010144 membrane-bound complex binding site; other site 443218010145 hinge residues; other site 443218010146 glutamate dehydrogenase; Provisional; Region: PRK09414 443218010147 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218010148 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 443218010149 NAD(P) binding site [chemical binding]; other site 443218010150 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218010151 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218010152 putative di-iron ligands [ion binding]; other site 443218010153 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218010154 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218010155 FAD binding pocket [chemical binding]; other site 443218010156 FAD binding motif [chemical binding]; other site 443218010157 phosphate binding motif [ion binding]; other site 443218010158 beta-alpha-beta structure motif; other site 443218010159 NAD binding pocket [chemical binding]; other site 443218010160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218010161 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218010162 catalytic loop [active] 443218010163 iron binding site [ion binding]; other site 443218010164 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 443218010165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010166 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 443218010167 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443218010168 catalytic triad [active] 443218010169 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218010170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010172 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 443218010173 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443218010174 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 443218010175 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218010176 phosphate binding site [ion binding]; other site 443218010177 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 443218010178 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218010179 active site 2 [active] 443218010180 active site 1 [active] 443218010181 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443218010182 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218010183 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 443218010184 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 443218010185 putative NAD(P) binding site [chemical binding]; other site 443218010186 active site 443218010187 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 443218010188 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218010189 active site 443218010190 Glucitol operon activator protein (GutM); Region: GutM; cl01890 443218010191 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443218010192 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443218010193 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443218010194 active site 443218010195 dimerization interface [polypeptide binding]; other site 443218010196 ribonuclease PH; Reviewed; Region: rph; PRK00173 443218010197 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443218010198 hexamer interface [polypeptide binding]; other site 443218010199 active site 443218010200 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443218010201 glutamate racemase; Provisional; Region: PRK00865 443218010202 Rhomboid family; Region: Rhomboid; cl11446 443218010203 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443218010204 putative active site pocket [active] 443218010205 cleavage site 443218010206 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443218010207 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 443218010208 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443218010209 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443218010210 active site 443218010211 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443218010212 Isochorismatase family; Region: Isochorismatase; pfam00857 443218010213 catalytic triad [active] 443218010214 metal binding site [ion binding]; metal-binding site 443218010215 conserved cis-peptide bond; other site 443218010216 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443218010217 DEAD/DEAH box helicase; Region: DEAD; pfam00270 443218010218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218010219 putative Mg++ binding site [ion binding]; other site 443218010220 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443218010221 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 443218010222 dimer interface [polypeptide binding]; other site 443218010223 putative active site [active] 443218010224 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218010225 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 443218010226 phosphoserine phosphatase SerB; Region: serB; TIGR00338 443218010227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218010228 motif II; other site 443218010229 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443218010230 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443218010231 D-pathway; other site 443218010232 Putative ubiquinol binding site [chemical binding]; other site 443218010233 Low-spin heme (heme b) binding site [chemical binding]; other site 443218010234 Putative water exit pathway; other site 443218010235 Binuclear center (heme o3/CuB) [ion binding]; other site 443218010236 K-pathway; other site 443218010237 Putative proton exit pathway; other site 443218010238 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218010239 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218010240 siderophore binding site; other site 443218010241 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443218010242 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443218010243 NADP+ binding site [chemical binding]; other site 443218010244 folate binding site [chemical binding]; other site 443218010245 thymidylate synthase; Reviewed; Region: thyA; PRK01827 443218010246 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 443218010247 dimerization interface [polypeptide binding]; other site 443218010248 active site 443218010249 MarR family; Region: MarR_2; pfam12802 443218010250 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218010251 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 443218010252 putative ligand binding site [chemical binding]; other site 443218010253 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 443218010254 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 443218010255 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 443218010256 multimer interface [polypeptide binding]; other site 443218010257 active site 443218010258 catalytic triad [active] 443218010259 dimer interface [polypeptide binding]; other site 443218010260 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443218010261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218010262 Walker A motif; other site 443218010263 ATP binding site [chemical binding]; other site 443218010264 Walker B motif; other site 443218010265 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443218010266 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 443218010267 nudix motif; other site 443218010268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218010269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218010270 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 443218010271 putative dimerization interface [polypeptide binding]; other site 443218010272 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 443218010273 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 443218010274 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 443218010275 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443218010276 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443218010277 dimer interface [polypeptide binding]; other site 443218010278 putative radical transfer pathway; other site 443218010279 diiron center [ion binding]; other site 443218010280 tyrosyl radical; other site 443218010281 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443218010282 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 443218010283 NAD binding site [chemical binding]; other site 443218010284 substrate binding site [chemical binding]; other site 443218010285 catalytic Zn binding site [ion binding]; other site 443218010286 tetramer interface [polypeptide binding]; other site 443218010287 structural Zn binding site [ion binding]; other site 443218010288 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218010289 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443218010290 MarR family; Region: MarR_2; cl17246 443218010291 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218010292 Phosphotransferase enzyme family; Region: APH; pfam01636 443218010293 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443218010294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218010295 RNA binding surface [nucleotide binding]; other site 443218010296 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 443218010297 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 443218010298 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443218010299 active site 443218010300 dimer interface [polypeptide binding]; other site 443218010301 catalytic residues [active] 443218010302 effector binding site; other site 443218010303 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443218010304 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 443218010305 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218010306 catalytic residues [active] 443218010307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010309 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 443218010310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218010311 Walker A/P-loop; other site 443218010312 ATP binding site [chemical binding]; other site 443218010313 Q-loop/lid; other site 443218010314 ABC transporter signature motif; other site 443218010315 Walker B; other site 443218010316 D-loop; other site 443218010317 H-loop/switch region; other site 443218010318 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 443218010319 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443218010320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 443218010321 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 443218010322 Predicted flavoprotein [General function prediction only]; Region: COG0431 443218010323 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218010324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218010327 MarR family; Region: MarR; pfam01047 443218010328 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 443218010329 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443218010330 homodimer interface [polypeptide binding]; other site 443218010331 NAD binding pocket [chemical binding]; other site 443218010332 ATP binding pocket [chemical binding]; other site 443218010333 Mg binding site [ion binding]; other site 443218010334 active-site loop [active] 443218010335 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443218010336 putative active site [active] 443218010337 redox center [active] 443218010338 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218010339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010340 Restriction endonuclease NaeI; Region: NaeI; pfam09126 443218010341 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 443218010342 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 443218010343 cofactor binding site; other site 443218010344 DNA binding site [nucleotide binding] 443218010345 substrate interaction site [chemical binding]; other site 443218010346 Uncharacterized conserved protein [Function unknown]; Region: COG2966 443218010347 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 443218010348 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218010349 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 443218010350 additional DNA contacts [nucleotide binding]; other site 443218010351 active site 443218010352 zinc binding site [ion binding]; other site 443218010353 DNA intercalation site [nucleotide binding]; other site 443218010354 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443218010355 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 443218010356 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 443218010357 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218010358 NAD(P) binding site [chemical binding]; other site 443218010359 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443218010360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218010361 S-adenosylmethionine binding site [chemical binding]; other site 443218010362 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218010363 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443218010364 active site 443218010365 catalytic site [active] 443218010366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218010367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218010368 DNA binding site [nucleotide binding] 443218010369 domain linker motif; other site 443218010370 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443218010371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218010372 putative DNA binding site [nucleotide binding]; other site 443218010373 putative Zn2+ binding site [ion binding]; other site 443218010374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443218010375 nucleotide binding site [chemical binding]; other site 443218010376 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 443218010377 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443218010378 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443218010379 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443218010380 phosphogluconate dehydratase; Validated; Region: PRK09054 443218010381 6-phosphogluconate dehydratase; Region: edd; TIGR01196 443218010382 glucokinase; Provisional; Region: glk; PRK00292 443218010383 glucokinase, proteobacterial type; Region: glk; TIGR00749 443218010384 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 443218010385 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 443218010386 active site 443218010387 intersubunit interface [polypeptide binding]; other site 443218010388 catalytic residue [active] 443218010389 EamA-like transporter family; Region: EamA; pfam00892 443218010390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218010391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218010392 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 443218010393 dimer interface [polypeptide binding]; other site 443218010394 ligand binding site [chemical binding]; other site 443218010395 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443218010396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218010397 Coenzyme A binding pocket [chemical binding]; other site 443218010398 RDD family; Region: RDD; pfam06271 443218010399 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443218010400 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443218010401 trehalose synthase; Region: treS_nterm; TIGR02456 443218010402 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443218010403 active site 443218010404 catalytic site [active] 443218010405 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218010406 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218010407 active site 2 [active] 443218010408 active site 1 [active] 443218010409 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443218010410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010412 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 443218010413 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 443218010414 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 443218010415 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 443218010416 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443218010417 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 443218010418 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443218010419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218010420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218010421 S-adenosylmethionine binding site [chemical binding]; other site 443218010422 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 443218010423 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443218010424 RibD C-terminal domain; Region: RibD_C; cl17279 443218010425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218010426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443218010427 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 443218010428 active site 443218010429 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 443218010430 putative NAD(P) binding site [chemical binding]; other site 443218010431 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218010432 Thioredoxin; Region: Thioredoxin_4; cl17273 443218010433 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 443218010434 Nucleoside recognition; Region: Gate; pfam07670 443218010435 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 443218010436 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218010437 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443218010438 SmpB-tmRNA interface; other site 443218010439 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443218010440 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 443218010441 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443218010442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218010443 Walker A/P-loop; other site 443218010444 ATP binding site [chemical binding]; other site 443218010445 Q-loop/lid; other site 443218010446 ABC transporter signature motif; other site 443218010447 Walker B; other site 443218010448 D-loop; other site 443218010449 H-loop/switch region; other site 443218010450 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443218010451 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443218010452 RF-1 domain; Region: RF-1; pfam00472 443218010453 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218010454 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 443218010455 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443218010456 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443218010457 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 443218010458 active site 443218010459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010461 active site 443218010462 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010464 active site 443218010465 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443218010466 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 443218010467 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218010468 short chain dehydrogenase; Provisional; Region: PRK07825 443218010469 classical (c) SDRs; Region: SDR_c; cd05233 443218010470 NAD(P) binding site [chemical binding]; other site 443218010471 active site 443218010472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010474 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 443218010475 hypothetical protein; Validated; Region: PRK00068 443218010476 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443218010477 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218010478 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443218010479 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443218010480 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 443218010481 Protein of unknown function DUF45; Region: DUF45; cl00636 443218010482 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 443218010483 ABC1 family; Region: ABC1; pfam03109 443218010484 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443218010485 active site 443218010486 ATP binding site [chemical binding]; other site 443218010487 Transcription factor WhiB; Region: Whib; pfam02467 443218010488 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443218010489 Part of AAA domain; Region: AAA_19; pfam13245 443218010490 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 443218010491 Family description; Region: UvrD_C_2; pfam13538 443218010492 HRDC domain; Region: HRDC; pfam00570 443218010493 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218010494 catalytic residues [active] 443218010495 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443218010496 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443218010497 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443218010498 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443218010499 putative NADH binding site [chemical binding]; other site 443218010500 putative active site [active] 443218010501 nudix motif; other site 443218010502 putative metal binding site [ion binding]; other site 443218010503 Ion channel; Region: Ion_trans_2; pfam07885 443218010504 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 443218010505 TrkA-N domain; Region: TrkA_N; pfam02254 443218010506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010507 NAD(P) binding site [chemical binding]; other site 443218010508 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443218010509 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 443218010510 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443218010511 Part of AAA domain; Region: AAA_19; pfam13245 443218010512 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 443218010513 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 443218010514 Condensation domain; Region: Condensation; pfam00668 443218010515 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218010516 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218010517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218010518 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218010519 catalytic site [active] 443218010520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218010521 active site 443218010522 DNA binding site [nucleotide binding] 443218010523 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443218010524 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443218010525 putative active site [active] 443218010526 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443218010527 putative active site [active] 443218010528 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 443218010529 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443218010530 active site 443218010531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 443218010532 DNA binding site [nucleotide binding] 443218010533 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 443218010534 nitrite reductase subunit NirD; Provisional; Region: PRK14989 443218010535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010536 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443218010537 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443218010538 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218010539 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 443218010540 cyanate transporter; Region: CynX; TIGR00896 443218010541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218010542 putative substrate translocation pore; other site 443218010543 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443218010544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218010545 DNA-binding site [nucleotide binding]; DNA binding site 443218010546 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443218010547 TIGR02569 family protein; Region: TIGR02569_actnb 443218010548 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443218010549 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443218010550 ATP binding site [chemical binding]; other site 443218010551 substrate interface [chemical binding]; other site 443218010552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218010553 active site residue [active] 443218010554 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 443218010555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010557 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 443218010558 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443218010559 dinuclear metal binding motif [ion binding]; other site 443218010560 helicase 45; Provisional; Region: PTZ00424 443218010561 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218010562 ATP binding site [chemical binding]; other site 443218010563 Mg++ binding site [ion binding]; other site 443218010564 motif III; other site 443218010565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218010566 nucleotide binding region [chemical binding]; other site 443218010567 ATP-binding site [chemical binding]; other site 443218010568 PQQ-like domain; Region: PQQ_2; pfam13360 443218010569 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218010570 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218010571 P-loop; other site 443218010572 Magnesium ion binding site [ion binding]; other site 443218010573 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218010574 Magnesium ion binding site [ion binding]; other site 443218010575 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443218010576 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443218010577 Transcription factor WhiB; Region: Whib; pfam02467 443218010578 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443218010579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218010580 PAS fold; Region: PAS_4; pfam08448 443218010581 putative active site [active] 443218010582 heme pocket [chemical binding]; other site 443218010583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443218010584 Histidine kinase; Region: HisKA_2; pfam07568 443218010585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010586 ATP binding site [chemical binding]; other site 443218010587 Mg2+ binding site [ion binding]; other site 443218010588 G-X-G motif; other site 443218010589 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218010590 carboxyltransferase (CT) interaction site; other site 443218010591 biotinylation site [posttranslational modification]; other site 443218010592 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 443218010593 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443218010594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218010595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218010596 DNA binding residues [nucleotide binding] 443218010597 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 443218010598 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443218010599 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443218010600 hinge; other site 443218010601 active site 443218010602 Predicted GTPases [General function prediction only]; Region: COG1162 443218010603 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443218010604 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443218010605 GTP/Mg2+ binding site [chemical binding]; other site 443218010606 G4 box; other site 443218010607 G5 box; other site 443218010608 G1 box; other site 443218010609 Switch I region; other site 443218010610 G2 box; other site 443218010611 G3 box; other site 443218010612 Switch II region; other site 443218010613 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218010614 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218010615 putative di-iron ligands [ion binding]; other site 443218010616 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218010617 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218010618 FAD binding pocket [chemical binding]; other site 443218010619 FAD binding motif [chemical binding]; other site 443218010620 phosphate binding motif [ion binding]; other site 443218010621 beta-alpha-beta structure motif; other site 443218010622 NAD binding pocket [chemical binding]; other site 443218010623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218010624 catalytic loop [active] 443218010625 iron binding site [ion binding]; other site 443218010626 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218010627 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218010628 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443218010629 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443218010630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443218010631 nucleotide binding region [chemical binding]; other site 443218010632 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443218010633 30S subunit binding site; other site 443218010634 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443218010635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218010636 active site 443218010637 lipoprotein LpqB; Provisional; Region: PRK13616 443218010638 Sporulation and spore germination; Region: Germane; pfam10646 443218010639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218010640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218010641 dimer interface [polypeptide binding]; other site 443218010642 phosphorylation site [posttranslational modification] 443218010643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010644 ATP binding site [chemical binding]; other site 443218010645 Mg2+ binding site [ion binding]; other site 443218010646 G-X-G motif; other site 443218010647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218010648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010649 active site 443218010650 phosphorylation site [posttranslational modification] 443218010651 intermolecular recognition site; other site 443218010652 dimerization interface [polypeptide binding]; other site 443218010653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218010654 DNA binding site [nucleotide binding] 443218010655 thymidylate kinase; Validated; Region: tmk; PRK00698 443218010656 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443218010657 TMP-binding site; other site 443218010658 ATP-binding site [chemical binding]; other site 443218010659 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443218010660 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443218010661 homotetramer interface [polypeptide binding]; other site 443218010662 ligand binding site [chemical binding]; other site 443218010663 catalytic site [active] 443218010664 NAD binding site [chemical binding]; other site 443218010665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218010667 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218010668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010669 Rubredoxin [Energy production and conversion]; Region: COG1773 443218010670 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443218010671 iron binding site [ion binding]; other site 443218010672 Rubredoxin [Energy production and conversion]; Region: COG1773 443218010673 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443218010674 iron binding site [ion binding]; other site 443218010675 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218010676 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218010677 Di-iron ligands [ion binding]; other site 443218010678 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443218010679 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443218010680 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443218010681 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443218010682 active site 443218010683 substrate binding site [chemical binding]; other site 443218010684 metal binding site [ion binding]; metal-binding site 443218010685 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443218010686 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 443218010687 Transcription factor WhiB; Region: Whib; pfam02467 443218010688 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 443218010689 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443218010690 phosphate binding site [ion binding]; other site 443218010691 dimer interface [polypeptide binding]; other site 443218010692 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 443218010693 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 443218010694 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 443218010695 FMN binding site [chemical binding]; other site 443218010696 dimer interface [polypeptide binding]; other site 443218010697 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 443218010698 nudix motif; other site 443218010699 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443218010700 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443218010701 active site 443218010702 Substrate binding site; other site 443218010703 Mg++ binding site; other site 443218010704 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218010705 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218010706 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443218010707 Probable Catalytic site; other site 443218010708 metal-binding site 443218010709 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443218010710 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443218010711 NADP binding site [chemical binding]; other site 443218010712 active site 443218010713 putative substrate binding site [chemical binding]; other site 443218010714 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443218010715 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218010716 TIGR03089 family protein; Region: TIGR03089 443218010717 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 443218010718 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 443218010719 probable active site [active] 443218010720 rhodanese superfamily protein; Provisional; Region: PRK05320 443218010721 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443218010722 active site residue [active] 443218010723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010725 active site 443218010726 phosphorylation site [posttranslational modification] 443218010727 intermolecular recognition site; other site 443218010728 dimerization interface [polypeptide binding]; other site 443218010729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010730 DNA binding residues [nucleotide binding] 443218010731 dimerization interface [polypeptide binding]; other site 443218010732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218010733 Histidine kinase; Region: HisKA_3; pfam07730 443218010734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010735 ATP binding site [chemical binding]; other site 443218010736 Mg2+ binding site [ion binding]; other site 443218010737 G-X-G motif; other site 443218010738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010739 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218010740 FAD binding site [chemical binding]; other site 443218010741 homotetramer interface [polypeptide binding]; other site 443218010742 substrate binding pocket [chemical binding]; other site 443218010743 catalytic base [active] 443218010744 AIR carboxylase; Region: AIRC; pfam00731 443218010745 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 443218010746 ATP-grasp domain; Region: ATP-grasp; pfam02222 443218010747 Predicted membrane protein [Function unknown]; Region: COG2246 443218010748 GtrA-like protein; Region: GtrA; pfam04138 443218010749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218010750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218010751 dimer interface [polypeptide binding]; other site 443218010752 phosphorylation site [posttranslational modification] 443218010753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010754 Mg2+ binding site [ion binding]; other site 443218010755 G-X-G motif; other site 443218010756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218010757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010758 active site 443218010759 phosphorylation site [posttranslational modification] 443218010760 intermolecular recognition site; other site 443218010761 dimerization interface [polypeptide binding]; other site 443218010762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218010763 DNA binding site [nucleotide binding] 443218010764 Bacterial PH domain; Region: DUF304; pfam03703 443218010765 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443218010766 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 443218010767 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443218010768 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218010769 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443218010770 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218010771 Maf-like protein; Region: Maf; pfam02545 443218010772 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443218010773 active site 443218010774 dimer interface [polypeptide binding]; other site 443218010775 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218010776 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443218010777 intersubunit interface [polypeptide binding]; other site 443218010778 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443218010779 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443218010780 active site residue [active] 443218010781 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443218010782 active site residue [active] 443218010783 Fe-S metabolism associated domain; Region: SufE; cl00951 443218010784 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218010785 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218010786 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443218010787 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443218010788 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218010789 carboxyltransferase (CT) interaction site; other site 443218010790 biotinylation site [posttranslational modification]; other site 443218010791 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218010792 Secretory lipase; Region: LIP; pfam03583 443218010793 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218010794 glycerol kinase; Provisional; Region: glpK; PRK00047 443218010795 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 443218010796 N- and C-terminal domain interface [polypeptide binding]; other site 443218010797 active site 443218010798 MgATP binding site [chemical binding]; other site 443218010799 catalytic site [active] 443218010800 metal binding site [ion binding]; metal-binding site 443218010801 putative homotetramer interface [polypeptide binding]; other site 443218010802 glycerol binding site [chemical binding]; other site 443218010803 homodimer interface [polypeptide binding]; other site 443218010804 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443218010805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218010806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218010808 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443218010809 dimerization interface [polypeptide binding]; other site 443218010810 putative active site pocket [active] 443218010811 putative catalytic residue [active] 443218010812 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218010813 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 443218010814 Walker A/P-loop; other site 443218010815 ATP binding site [chemical binding]; other site 443218010816 Q-loop/lid; other site 443218010817 ABC transporter signature motif; other site 443218010818 Walker B; other site 443218010819 D-loop; other site 443218010820 H-loop/switch region; other site 443218010821 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 443218010822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010823 dimer interface [polypeptide binding]; other site 443218010824 conserved gate region; other site 443218010825 ABC-ATPase subunit interface; other site 443218010826 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 443218010827 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218010828 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443218010829 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 443218010830 metal binding site [ion binding]; metal-binding site 443218010831 putative dimer interface [polypeptide binding]; other site 443218010832 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218010833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218010834 substrate binding site [chemical binding]; other site 443218010835 oxyanion hole (OAH) forming residues; other site 443218010836 trimer interface [polypeptide binding]; other site 443218010837 AMP-binding enzyme; Region: AMP-binding; pfam00501 443218010838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218010839 active site 443218010840 CoA binding site [chemical binding]; other site 443218010841 AMP binding site [chemical binding]; other site 443218010842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218010843 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 443218010844 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443218010845 hypothetical protein; Provisional; Region: PRK14851 443218010846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218010847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010848 NAD(P) binding site [chemical binding]; other site 443218010849 active site 443218010850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010852 active site 443218010853 phosphorylation site [posttranslational modification] 443218010854 intermolecular recognition site; other site 443218010855 dimerization interface [polypeptide binding]; other site 443218010856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010857 DNA binding residues [nucleotide binding] 443218010858 dimerization interface [polypeptide binding]; other site 443218010859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218010860 Ligand Binding Site [chemical binding]; other site 443218010861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218010862 Ligand Binding Site [chemical binding]; other site 443218010863 purine nucleoside phosphorylase; Provisional; Region: PRK08202 443218010864 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443218010865 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443218010866 active site 443218010867 substrate binding site [chemical binding]; other site 443218010868 metal binding site [ion binding]; metal-binding site 443218010869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218010870 active site 443218010871 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218010872 NlpC/P60 family; Region: NLPC_P60; pfam00877 443218010873 adenosine deaminase; Provisional; Region: PRK09358 443218010874 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443218010875 active site 443218010876 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443218010877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218010878 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218010879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443218010880 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218010881 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218010882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010883 dimer interface [polypeptide binding]; other site 443218010884 conserved gate region; other site 443218010885 putative PBP binding loops; other site 443218010886 ABC-ATPase subunit interface; other site 443218010887 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218010888 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 443218010889 Walker A/P-loop; other site 443218010890 ATP binding site [chemical binding]; other site 443218010891 Q-loop/lid; other site 443218010892 ABC transporter signature motif; other site 443218010893 Walker B; other site 443218010894 D-loop; other site 443218010895 H-loop/switch region; other site 443218010896 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 443218010897 NMT1-like family; Region: NMT1_2; pfam13379 443218010898 membrane-bound complex binding site; other site 443218010899 hinge residues; other site 443218010900 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 443218010901 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443218010902 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218010903 AsnC family; Region: AsnC_trans_reg; pfam01037 443218010904 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443218010905 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443218010906 substrate binding site [chemical binding]; other site 443218010907 ligand binding site [chemical binding]; other site 443218010908 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443218010909 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443218010910 substrate binding site [chemical binding]; other site 443218010911 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 443218010912 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 443218010913 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218010914 dimer interface [polypeptide binding]; other site 443218010915 PYR/PP interface [polypeptide binding]; other site 443218010916 TPP binding site [chemical binding]; other site 443218010917 substrate binding site [chemical binding]; other site 443218010918 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443218010919 TPP-binding site; other site 443218010920 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443218010921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218010922 H-loop/switch region; other site 443218010923 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 443218010924 NMT1-like family; Region: NMT1_2; pfam13379 443218010925 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443218010926 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 443218010927 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443218010928 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 443218010929 active site 443218010930 non-prolyl cis peptide bond; other site 443218010931 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010932 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443218010933 active site 443218010934 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 443218010935 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443218010936 active site 443218010937 non-prolyl cis peptide bond; other site 443218010938 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218010939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010940 dimer interface [polypeptide binding]; other site 443218010941 conserved gate region; other site 443218010942 putative PBP binding loops; other site 443218010943 ABC-ATPase subunit interface; other site 443218010944 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218010945 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 443218010946 Walker A/P-loop; other site 443218010947 ATP binding site [chemical binding]; other site 443218010948 Q-loop/lid; other site 443218010949 ABC transporter signature motif; other site 443218010950 Walker B; other site 443218010951 D-loop; other site 443218010952 H-loop/switch region; other site 443218010953 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 443218010954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218010955 membrane-bound complex binding site; other site 443218010956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443218010957 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218010958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218010959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218010960 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218010961 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218010962 Protein of unknown function (DUF998); Region: DUF998; pfam06197 443218010963 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218010964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218010965 Walker A/P-loop; other site 443218010966 ATP binding site [chemical binding]; other site 443218010967 Q-loop/lid; other site 443218010968 ABC transporter signature motif; other site 443218010969 Walker B; other site 443218010970 D-loop; other site 443218010971 H-loop/switch region; other site 443218010972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218010973 Histidine kinase; Region: HisKA_3; pfam07730 443218010974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010975 ATP binding site [chemical binding]; other site 443218010976 Mg2+ binding site [ion binding]; other site 443218010977 G-X-G motif; other site 443218010978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010980 active site 443218010981 phosphorylation site [posttranslational modification] 443218010982 intermolecular recognition site; other site 443218010983 dimerization interface [polypeptide binding]; other site 443218010984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010985 DNA binding residues [nucleotide binding] 443218010986 dimerization interface [polypeptide binding]; other site 443218010987 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 443218010988 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443218010989 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443218010990 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443218010991 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443218010992 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 443218010993 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 443218010994 active site 443218010995 dimer interface [polypeptide binding]; other site 443218010996 non-prolyl cis peptide bond; other site 443218010997 insertion regions; other site 443218010998 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443218010999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011000 active site 443218011001 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 443218011002 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 443218011003 active site 443218011004 dimer interface [polypeptide binding]; other site 443218011005 non-prolyl cis peptide bond; other site 443218011006 insertion regions; other site 443218011007 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443218011008 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443218011009 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443218011010 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218011011 E3 interaction surface; other site 443218011012 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443218011013 active site 443218011014 catalytic motif [active] 443218011015 Zn binding site [ion binding]; other site 443218011016 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443218011017 putative Iron-sulfur protein interface [polypeptide binding]; other site 443218011018 putative proximal heme binding site [chemical binding]; other site 443218011019 putative SdhD-like interface [polypeptide binding]; other site 443218011020 putative distal heme binding site [chemical binding]; other site 443218011021 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443218011022 putative Iron-sulfur protein interface [polypeptide binding]; other site 443218011023 putative proximal heme binding site [chemical binding]; other site 443218011024 putative SdhC-like subunit interface [polypeptide binding]; other site 443218011025 putative distal heme binding site [chemical binding]; other site 443218011026 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443218011027 L-aspartate oxidase; Provisional; Region: PRK06175 443218011028 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218011029 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443218011030 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443218011031 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 443218011032 nudix motif; other site 443218011033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218011034 DNA binding site [nucleotide binding] 443218011035 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 443218011036 putative ligand binding site [chemical binding]; other site 443218011037 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443218011038 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218011039 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218011041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218011042 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218011043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011045 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 443218011046 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443218011047 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443218011048 catalytic triad [active] 443218011049 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218011050 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218011051 acyl-activating enzyme (AAE) consensus motif; other site 443218011052 putative AMP binding site [chemical binding]; other site 443218011053 putative active site [active] 443218011054 putative CoA binding site [chemical binding]; other site 443218011055 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218011056 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 443218011057 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218011058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011059 NAD(P) binding site [chemical binding]; other site 443218011060 active site 443218011061 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218011062 classical (c) SDRs; Region: SDR_c; cd05233 443218011063 NAD(P) binding site [chemical binding]; other site 443218011064 active site 443218011065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011067 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218011068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218011069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218011070 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218011071 FAD binding domain; Region: FAD_binding_4; pfam01565 443218011072 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443218011073 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 443218011074 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443218011075 dimer interface [polypeptide binding]; other site 443218011076 active site 443218011077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218011078 substrate binding site [chemical binding]; other site 443218011079 catalytic residue [active] 443218011080 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 443218011081 putative FMN binding site [chemical binding]; other site 443218011082 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443218011083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218011084 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443218011085 Walker A/P-loop; other site 443218011086 ATP binding site [chemical binding]; other site 443218011087 Q-loop/lid; other site 443218011088 ABC transporter signature motif; other site 443218011089 Walker B; other site 443218011090 D-loop; other site 443218011091 H-loop/switch region; other site 443218011092 multicopper oxidase; Provisional; Region: PRK10965 443218011093 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443218011094 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443218011095 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 443218011096 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218011097 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218011098 FAD binding pocket [chemical binding]; other site 443218011099 FAD binding motif [chemical binding]; other site 443218011100 phosphate binding motif [ion binding]; other site 443218011101 NAD binding pocket [chemical binding]; other site 443218011102 Secretory lipase; Region: LIP; pfam03583 443218011103 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443218011104 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443218011105 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443218011106 Walker A/P-loop; other site 443218011107 ATP binding site [chemical binding]; other site 443218011108 Q-loop/lid; other site 443218011109 ABC transporter signature motif; other site 443218011110 Walker B; other site 443218011111 D-loop; other site 443218011112 H-loop/switch region; other site 443218011113 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443218011114 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443218011115 Walker A/P-loop; other site 443218011116 ATP binding site [chemical binding]; other site 443218011117 Q-loop/lid; other site 443218011118 ABC transporter signature motif; other site 443218011119 Walker B; other site 443218011120 D-loop; other site 443218011121 H-loop/switch region; other site 443218011122 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218011123 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443218011124 acyl-activating enzyme (AAE) consensus motif; other site 443218011125 putative AMP binding site [chemical binding]; other site 443218011126 putative active site [active] 443218011127 putative CoA binding site [chemical binding]; other site 443218011128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443218011129 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218011130 TM-ABC transporter signature motif; other site 443218011131 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443218011132 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218011133 TM-ABC transporter signature motif; other site 443218011134 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218011135 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 443218011136 ligand binding site [chemical binding]; other site 443218011137 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443218011138 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443218011139 Walker A/P-loop; other site 443218011140 ATP binding site [chemical binding]; other site 443218011141 Q-loop/lid; other site 443218011142 ABC transporter signature motif; other site 443218011143 Walker B; other site 443218011144 D-loop; other site 443218011145 H-loop/switch region; other site 443218011146 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443218011147 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443218011148 TM-ABC transporter signature motif; other site 443218011149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 443218011150 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 443218011151 putative ligand binding site [chemical binding]; other site 443218011152 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443218011153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218011154 DNA-binding site [nucleotide binding]; DNA binding site 443218011155 UTRA domain; Region: UTRA; pfam07702 443218011156 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218011157 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 443218011158 substrate binding site [chemical binding]; other site 443218011159 ATP binding site [chemical binding]; other site 443218011160 KduI/IolB family; Region: KduI; pfam04962 443218011161 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 443218011162 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218011163 PYR/PP interface [polypeptide binding]; other site 443218011164 dimer interface [polypeptide binding]; other site 443218011165 TPP binding site [chemical binding]; other site 443218011166 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443218011167 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 443218011168 TPP-binding site; other site 443218011169 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218011170 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443218011171 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218011172 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443218011173 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443218011174 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218011175 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443218011176 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443218011177 tetrameric interface [polypeptide binding]; other site 443218011178 NAD binding site [chemical binding]; other site 443218011179 catalytic residues [active] 443218011180 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443218011181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218011182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443218011183 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443218011184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011188 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443218011189 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443218011190 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 443218011191 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443218011192 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443218011193 active site 443218011194 HIGH motif; other site 443218011195 dimer interface [polypeptide binding]; other site 443218011196 KMSKS motif; other site 443218011197 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 443218011198 putative active site [active] 443218011199 putative catalytic site [active] 443218011200 putative DNA binding site [nucleotide binding]; other site 443218011201 putative phosphate binding site [ion binding]; other site 443218011202 metal binding site A [ion binding]; metal-binding site 443218011203 putative AP binding site [nucleotide binding]; other site 443218011204 putative metal binding site B [ion binding]; other site 443218011205 MFS transport protein AraJ; Provisional; Region: PRK10091 443218011206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218011207 putative substrate translocation pore; other site 443218011208 isocitrate dehydrogenase; Validated; Region: PRK08299 443218011209 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443218011210 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218011211 homodimer interface [polypeptide binding]; other site 443218011212 substrate-cofactor binding pocket; other site 443218011213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218011214 catalytic residue [active] 443218011215 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443218011216 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443218011217 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 443218011218 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218011219 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218011220 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218011221 homodimer interface [polypeptide binding]; other site 443218011222 NADP binding site [chemical binding]; other site 443218011223 substrate binding site [chemical binding]; other site 443218011224 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443218011225 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443218011226 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443218011227 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443218011228 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218011229 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011231 active site 443218011232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011234 active site 443218011235 short chain dehydrogenase; Provisional; Region: PRK07791 443218011236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011237 NAD(P) binding site [chemical binding]; other site 443218011238 active site 443218011239 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218011240 active site 443218011241 catalytic site [active] 443218011242 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218011243 active site 2 [active] 443218011244 active site 1 [active] 443218011245 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218011246 hydrophobic ligand binding site; other site 443218011247 lipid-transfer protein; Provisional; Region: PRK08256 443218011248 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218011249 active site 443218011250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011252 enoyl-CoA hydratase; Provisional; Region: PRK09245 443218011253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218011254 substrate binding site [chemical binding]; other site 443218011255 oxyanion hole (OAH) forming residues; other site 443218011256 trimer interface [polypeptide binding]; other site 443218011257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218011258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218011259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218011260 active site 443218011261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218011262 catalytic tetrad [active] 443218011263 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218011264 cyclase homology domain; Region: CHD; cd07302 443218011265 nucleotidyl binding site; other site 443218011266 metal binding site [ion binding]; metal-binding site 443218011267 dimer interface [polypeptide binding]; other site 443218011268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218011269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218011270 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 443218011271 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 443218011272 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443218011273 active site 443218011274 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443218011275 generic binding surface II; other site 443218011276 generic binding surface I; other site 443218011277 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218011278 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218011279 DNA binding residues [nucleotide binding] 443218011280 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443218011281 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443218011282 putative dimer interface [polypeptide binding]; other site 443218011283 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218011284 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218011285 DNA Polymerase Y-family; Region: PolY_like; cd03468 443218011286 active site 443218011287 DNA binding site [nucleotide binding] 443218011288 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218011289 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218011290 active site 443218011291 ATP binding site [chemical binding]; other site 443218011292 substrate binding site [chemical binding]; other site 443218011293 activation loop (A-loop); other site 443218011294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011296 active site 443218011297 phosphorylation site [posttranslational modification] 443218011298 intermolecular recognition site; other site 443218011299 dimerization interface [polypeptide binding]; other site 443218011300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011301 DNA binding residues [nucleotide binding] 443218011302 dimerization interface [polypeptide binding]; other site 443218011303 PspC domain; Region: PspC; cl00864 443218011304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218011305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218011306 ATP binding site [chemical binding]; other site 443218011307 Mg2+ binding site [ion binding]; other site 443218011308 G-X-G motif; other site 443218011309 PspC domain; Region: PspC; pfam04024 443218011310 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443218011311 active site 443218011312 GMP synthase; Reviewed; Region: guaA; PRK00074 443218011313 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443218011314 AMP/PPi binding site [chemical binding]; other site 443218011315 candidate oxyanion hole; other site 443218011316 catalytic triad [active] 443218011317 potential glutamine specificity residues [chemical binding]; other site 443218011318 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443218011319 ATP Binding subdomain [chemical binding]; other site 443218011320 Ligand Binding sites [chemical binding]; other site 443218011321 Dimerization subdomain; other site 443218011322 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 443218011323 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443218011324 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218011325 Na binding site [ion binding]; other site 443218011326 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218011327 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218011328 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443218011329 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443218011330 active site 443218011331 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443218011332 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218011333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443218011334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443218011335 active site 443218011336 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 443218011337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218011338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218011339 DNA binding residues [nucleotide binding] 443218011340 Transcription factor WhiB; Region: Whib; pfam02467 443218011341 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443218011342 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218011343 ring oligomerisation interface [polypeptide binding]; other site 443218011344 ATP/Mg binding site [chemical binding]; other site 443218011345 stacking interactions; other site 443218011346 hinge regions; other site 443218011347 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443218011348 oligomerisation interface [polypeptide binding]; other site 443218011349 mobile loop; other site 443218011350 roof hairpin; other site 443218011351 UGMP family protein; Validated; Region: PRK09604 443218011352 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443218011353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218011354 Coenzyme A binding pocket [chemical binding]; other site 443218011355 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443218011356 Glycoprotease family; Region: Peptidase_M22; pfam00814 443218011357 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 443218011358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443218011359 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218011360 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218011361 TAP-like protein; Region: Abhydrolase_4; pfam08386 443218011362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443218011363 alanine racemase; Reviewed; Region: alr; PRK00053 443218011364 active site 443218011365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218011366 dimer interface [polypeptide binding]; other site 443218011367 substrate binding site [chemical binding]; other site 443218011368 catalytic residues [active] 443218011369 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443218011370 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443218011371 putative substrate binding site [chemical binding]; other site 443218011372 putative ATP binding site [chemical binding]; other site 443218011373 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443218011374 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443218011375 glutaminase active site [active] 443218011376 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443218011377 dimer interface [polypeptide binding]; other site 443218011378 active site 443218011379 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443218011380 dimer interface [polypeptide binding]; other site 443218011381 active site 443218011382 chlorophyllase; Region: PLN00021 443218011383 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 443218011384 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443218011385 active site 443218011386 substrate binding site [chemical binding]; other site 443218011387 metal binding site [ion binding]; metal-binding site 443218011388 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443218011389 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443218011390 23S rRNA interface [nucleotide binding]; other site 443218011391 L3 interface [polypeptide binding]; other site 443218011392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443218011393 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443218011394 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 443218011395 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443218011396 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443218011397 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443218011398 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443218011399 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443218011400 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 443218011401 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443218011402 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443218011403 active site 443218011404 catalytic residues [active] 443218011405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011407 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443218011408 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 443218011409 active site 443218011410 intersubunit interface [polypeptide binding]; other site 443218011411 zinc binding site [ion binding]; other site 443218011412 Na+ binding site [ion binding]; other site 443218011413 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 443218011414 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218011415 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443218011416 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443218011417 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443218011418 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218011419 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218011420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218011421 putative acyl-acceptor binding pocket; other site 443218011422 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 443218011423 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443218011424 putative acyl-acceptor binding pocket; other site 443218011425 YibE/F-like protein; Region: YibE_F; pfam07907 443218011426 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443218011427 putative active site [active] 443218011428 redox center [active] 443218011429 Thioredoxin; Region: Thioredoxin_4; pfam13462 443218011430 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443218011431 enoyl-CoA hydratase; Provisional; Region: PRK07509 443218011432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218011433 substrate binding site [chemical binding]; other site 443218011434 oxyanion hole (OAH) forming residues; other site 443218011435 trimer interface [polypeptide binding]; other site 443218011436 Condensation domain; Region: Condensation; pfam00668 443218011437 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218011438 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011439 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218011440 acyl-activating enzyme (AAE) consensus motif; other site 443218011441 AMP binding site [chemical binding]; other site 443218011442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011443 Condensation domain; Region: Condensation; pfam00668 443218011444 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443218011445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011446 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011447 acyl-activating enzyme (AAE) consensus motif; other site 443218011448 AMP binding site [chemical binding]; other site 443218011449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011450 peptide synthase; Provisional; Region: PRK12467 443218011451 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011452 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011453 acyl-activating enzyme (AAE) consensus motif; other site 443218011454 AMP binding site [chemical binding]; other site 443218011455 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011458 acyl-activating enzyme (AAE) consensus motif; other site 443218011459 AMP binding site [chemical binding]; other site 443218011460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011461 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218011462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011463 acyl-activating enzyme (AAE) consensus motif; other site 443218011464 AMP binding site [chemical binding]; other site 443218011465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011466 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218011467 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218011469 acyl-activating enzyme (AAE) consensus motif; other site 443218011470 AMP binding site [chemical binding]; other site 443218011471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218011472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218011473 active site 443218011474 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218011475 classical (c) SDRs; Region: SDR_c; cd05233 443218011476 NAD(P) binding site [chemical binding]; other site 443218011477 active site 443218011478 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443218011479 Clp amino terminal domain; Region: Clp_N; pfam02861 443218011480 Clp amino terminal domain; Region: Clp_N; pfam02861 443218011481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218011482 Walker A motif; other site 443218011483 ATP binding site [chemical binding]; other site 443218011484 Walker B motif; other site 443218011485 arginine finger; other site 443218011486 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 443218011487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218011488 Walker A motif; other site 443218011489 ATP binding site [chemical binding]; other site 443218011490 Walker B motif; other site 443218011491 arginine finger; other site 443218011492 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443218011493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011495 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 443218011496 DNA binding residues [nucleotide binding] 443218011497 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218011498 putative dimer interface [polypeptide binding]; other site 443218011499 chaperone protein DnaJ; Provisional; Region: PRK14279 443218011500 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443218011501 HSP70 interaction site [polypeptide binding]; other site 443218011502 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443218011503 Zn binding sites [ion binding]; other site 443218011504 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443218011505 dimer interface [polypeptide binding]; other site 443218011506 GrpE; Region: GrpE; pfam01025 443218011507 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443218011508 dimer interface [polypeptide binding]; other site 443218011509 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443218011510 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443218011511 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 443218011512 nucleotide binding site [chemical binding]; other site 443218011513 NEF interaction site [polypeptide binding]; other site 443218011514 SBD interface [polypeptide binding]; other site 443218011515 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443218011516 Dynamin family; Region: Dynamin_N; pfam00350 443218011517 G1 box; other site 443218011518 GTP/Mg2+ binding site [chemical binding]; other site 443218011519 G2 box; other site 443218011520 Switch I region; other site 443218011521 G3 box; other site 443218011522 Switch II region; other site 443218011523 G4 box; other site 443218011524 G5 box; other site 443218011525 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443218011526 Dynamin family; Region: Dynamin_N; pfam00350 443218011527 G1 box; other site 443218011528 GTP/Mg2+ binding site [chemical binding]; other site 443218011529 G2 box; other site 443218011530 Switch I region; other site 443218011531 G3 box; other site 443218011532 Switch II region; other site 443218011533 G4 box; other site 443218011534 G5 box; other site 443218011535 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218011536 nucleotide binding site [chemical binding]; other site 443218011537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443218011538 Walker A motif; other site 443218011539 ATP binding site [chemical binding]; other site 443218011540 Walker B motif; other site 443218011541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011543 DNA binding residues [nucleotide binding] 443218011544 dimerization interface [polypeptide binding]; other site 443218011545 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218011546 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443218011547 4Fe-4S binding domain; Region: Fer4; cl02805 443218011548 4Fe-4S binding domain; Region: Fer4; pfam00037 443218011549 Cysteine-rich domain; Region: CCG; pfam02754 443218011550 Cysteine-rich domain; Region: CCG; pfam02754 443218011551 histidinol-phosphate aminotransferase; Provisional; Region: PRK14807 443218011552 aminotransferase AlaT; Validated; Region: PRK09265 443218011553 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218011554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218011555 homodimer interface [polypeptide binding]; other site 443218011556 catalytic residue [active] 443218011557 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218011558 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443218011559 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443218011560 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443218011561 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443218011562 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218011563 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218011564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218011565 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443218011566 Methyltransferase domain; Region: Methyltransf_24; pfam13578 443218011567 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443218011568 trimer interface [polypeptide binding]; other site 443218011569 active site 443218011570 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 443218011571 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218011572 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218011573 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 443218011574 FAD binding site [chemical binding]; other site 443218011575 substrate binding site [chemical binding]; other site 443218011576 catalytic residues [active] 443218011577 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218011578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218011579 Walker A/P-loop; other site 443218011580 ATP binding site [chemical binding]; other site 443218011581 Q-loop/lid; other site 443218011582 ABC transporter signature motif; other site 443218011583 Walker B; other site 443218011584 Predicted membrane protein [Function unknown]; Region: COG1511 443218011585 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443218011586 Predicted membrane protein [Function unknown]; Region: COG1511 443218011587 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218011588 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443218011589 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 443218011590 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 443218011591 NADP binding site [chemical binding]; other site 443218011592 dimer interface [polypeptide binding]; other site 443218011593 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 443218011594 VanW like protein; Region: VanW; pfam04294 443218011595 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 443218011596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218011597 dimer interface [polypeptide binding]; other site 443218011598 active site 443218011599 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 443218011600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011601 NAD(P) binding site [chemical binding]; other site 443218011602 active site 443218011603 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218011604 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218011605 active site 2 [active] 443218011606 active site 1 [active] 443218011607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011609 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443218011610 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443218011611 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218011612 Ligand Binding Site [chemical binding]; other site 443218011613 isochorismate synthase DhbC; Validated; Region: PRK06923 443218011614 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443218011615 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 443218011616 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 443218011617 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 443218011618 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 443218011619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218011620 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218011621 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218011622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218011623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011624 S-adenosylmethionine binding site [chemical binding]; other site 443218011625 Dodecin; Region: Dodecin; pfam07311 443218011626 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218011627 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443218011628 active site 443218011629 substrate-binding site [chemical binding]; other site 443218011630 metal-binding site [ion binding] 443218011631 GTP binding site [chemical binding]; other site 443218011632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011633 S-adenosylmethionine binding site [chemical binding]; other site 443218011634 LabA_like proteins; Region: LabA_like; cd06167 443218011635 putative metal binding site [ion binding]; other site 443218011636 MMPL family; Region: MMPL; pfam03176 443218011637 MMPL family; Region: MMPL; pfam03176 443218011638 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 443218011639 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 443218011640 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 443218011641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218011642 dimerization interface [polypeptide binding]; other site 443218011643 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218011644 cyclase homology domain; Region: CHD; cd07302 443218011645 nucleotidyl binding site; other site 443218011646 metal binding site [ion binding]; metal-binding site 443218011647 dimer interface [polypeptide binding]; other site 443218011648 Predicted integral membrane protein [Function unknown]; Region: COG0392 443218011649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218011650 dimerization interface [polypeptide binding]; other site 443218011651 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218011652 cyclase homology domain; Region: CHD; cd07302 443218011653 nucleotidyl binding site; other site 443218011654 metal binding site [ion binding]; metal-binding site 443218011655 dimer interface [polypeptide binding]; other site 443218011656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218011657 dimerization interface [polypeptide binding]; other site 443218011658 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218011659 cyclase homology domain; Region: CHD; cd07302 443218011660 nucleotidyl binding site; other site 443218011661 metal binding site [ion binding]; metal-binding site 443218011662 dimer interface [polypeptide binding]; other site 443218011663 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443218011664 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443218011665 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443218011666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443218011667 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443218011668 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218011669 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218011670 Pirin; Region: Pirin; pfam02678 443218011671 Pirin-related protein [General function prediction only]; Region: COG1741 443218011672 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218011673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011674 S-adenosylmethionine binding site [chemical binding]; other site 443218011675 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218011676 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443218011677 catalytic residues [active] 443218011678 catalytic nucleophile [active] 443218011679 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218011680 Probable transposase; Region: OrfB_IS605; pfam01385 443218011681 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218011682 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 443218011683 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443218011684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218011685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218011686 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218011687 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443218011688 hypothetical protein; Provisional; Region: PRK11622 443218011689 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 443218011690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218011691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218011692 putative PBP binding loops; other site 443218011693 ABC-ATPase subunit interface; other site 443218011694 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218011695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218011696 Walker A/P-loop; other site 443218011697 ATP binding site [chemical binding]; other site 443218011698 Q-loop/lid; other site 443218011699 ABC transporter signature motif; other site 443218011700 Walker B; other site 443218011701 D-loop; other site 443218011702 H-loop/switch region; other site 443218011703 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443218011704 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 443218011705 dimer interface [polypeptide binding]; other site 443218011706 active site 443218011707 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218011708 catalytic residues [active] 443218011709 substrate binding site [chemical binding]; other site 443218011710 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 443218011711 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 443218011712 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443218011713 dimer interface [polypeptide binding]; other site 443218011714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218011715 catalytic residue [active] 443218011716 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218011717 ATPase involved in DNA repair; Region: DUF3686; pfam12458 443218011718 AAA domain; Region: AAA_22; pfam13401 443218011719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218011720 Walker A motif; other site 443218011721 ATP binding site [chemical binding]; other site 443218011722 Walker B motif; other site 443218011723 arginine finger; other site 443218011724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 443218011725 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 443218011726 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 443218011727 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443218011728 active site 443218011729 Zn binding site [ion binding]; other site 443218011730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443218011731 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443218011732 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443218011733 Predicted membrane protein [Function unknown]; Region: COG4763 443218011734 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443218011735 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218011736 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218011737 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218011738 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218011739 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443218011740 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443218011741 active site 443218011742 DNA binding site [nucleotide binding] 443218011743 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443218011744 DNA binding site [nucleotide binding] 443218011745 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218011746 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443218011747 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443218011748 nucleotide binding site [chemical binding]; other site 443218011749 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 443218011750 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443218011751 active site 443218011752 DNA binding site [nucleotide binding] 443218011753 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443218011754 DNA binding site [nucleotide binding] 443218011755 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443218011756 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443218011757 putative DNA binding site [nucleotide binding]; other site 443218011758 putative homodimer interface [polypeptide binding]; other site 443218011759 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 443218011760 allantoicase; Provisional; Region: PRK13257 443218011761 Allantoicase repeat; Region: Allantoicase; pfam03561 443218011762 Allantoicase repeat; Region: Allantoicase; pfam03561 443218011763 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 443218011764 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 443218011765 active site 443218011766 catalytic site [active] 443218011767 tetramer interface [polypeptide binding]; other site 443218011768 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 443218011769 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 443218011770 Na binding site [ion binding]; other site 443218011771 substrate binding site [chemical binding]; other site 443218011772 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218011773 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218011774 dimerization interface [polypeptide binding]; other site 443218011775 putative DNA binding site [nucleotide binding]; other site 443218011776 putative Zn2+ binding site [ion binding]; other site 443218011777 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 443218011778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218011779 putative metal binding site [ion binding]; other site 443218011780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218011781 catalytic loop [active] 443218011782 iron binding site [ion binding]; other site 443218011783 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443218011784 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 443218011785 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 443218011786 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443218011787 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 443218011788 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 443218011789 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 443218011790 active site 443218011791 putative substrate binding pocket [chemical binding]; other site 443218011792 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 443218011793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218011794 short chain dehydrogenase; Provisional; Region: PRK05872 443218011795 classical (c) SDRs; Region: SDR_c; cd05233 443218011796 NAD(P) binding site [chemical binding]; other site 443218011797 active site 443218011798 guanine deaminase; Region: guan_deamin; TIGR02967 443218011799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218011800 active site 443218011801 urate oxidase; Region: urate_oxi; TIGR03383 443218011802 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 443218011803 active site 443218011804 putative OHCU decarboxylase; Provisional; Region: PRK13798 443218011805 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443218011806 Ligand binding site; other site 443218011807 metal-binding site 443218011808 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 443218011809 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218011810 DNA binding residues [nucleotide binding] 443218011811 drug binding residues [chemical binding]; other site 443218011812 dimer interface [polypeptide binding]; other site 443218011813 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 443218011814 beta-clamp/clamp loader binding surface; other site 443218011815 beta-clamp/translesion DNA polymerase binding surface; other site 443218011816 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218011817 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218011819 short chain dehydrogenase; Provisional; Region: PRK06914 443218011820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011821 NAD(P) binding site [chemical binding]; other site 443218011822 active site 443218011823 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 443218011824 NmrA-like family; Region: NmrA; pfam05368 443218011825 NADP binding site [chemical binding]; other site 443218011826 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218011828 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218011829 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443218011830 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 443218011831 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443218011832 tetramer interface [polypeptide binding]; other site 443218011833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218011834 catalytic residue [active] 443218011835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218011836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218011837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218011838 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218011839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218011840 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 443218011841 nucleotide binding site [chemical binding]; other site 443218011842 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218011843 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218011844 intersubunit interface [polypeptide binding]; other site 443218011845 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443218011846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218011847 ABC-ATPase subunit interface; other site 443218011848 dimer interface [polypeptide binding]; other site 443218011849 putative PBP binding regions; other site 443218011850 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 443218011851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218011852 ABC-ATPase subunit interface; other site 443218011853 dimer interface [polypeptide binding]; other site 443218011854 putative PBP binding regions; other site 443218011855 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218011856 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218011857 Walker A/P-loop; other site 443218011858 ATP binding site [chemical binding]; other site 443218011859 Q-loop/lid; other site 443218011860 ABC transporter signature motif; other site 443218011861 Walker B; other site 443218011862 D-loop; other site 443218011863 H-loop/switch region; other site 443218011864 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443218011865 dimer interface [polypeptide binding]; other site 443218011866 [2Fe-2S] cluster binding site [ion binding]; other site 443218011867 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 443218011868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218011869 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218011870 lipoyl synthase; Provisional; Region: PRK05481 443218011871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218011872 FeS/SAM binding site; other site 443218011873 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443218011874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011875 acetoin reductases; Region: 23BDH; TIGR02415 443218011876 NAD(P) binding site [chemical binding]; other site 443218011877 active site 443218011878 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 443218011879 ATP-NAD kinase; Region: NAD_kinase; pfam01513 443218011880 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 443218011881 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443218011882 tetramer interface [polypeptide binding]; other site 443218011883 TPP-binding site [chemical binding]; other site 443218011884 heterodimer interface [polypeptide binding]; other site 443218011885 phosphorylation loop region [posttranslational modification] 443218011886 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443218011887 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443218011888 alpha subunit interface [polypeptide binding]; other site 443218011889 TPP binding site [chemical binding]; other site 443218011890 heterodimer interface [polypeptide binding]; other site 443218011891 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218011892 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 443218011893 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218011894 E3 interaction surface; other site 443218011895 lipoyl attachment site [posttranslational modification]; other site 443218011896 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443218011897 catalytic site [active] 443218011898 GAF domain; Region: GAF; pfam01590 443218011899 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 443218011900 putative OHCU decarboxylase; Provisional; Region: PRK13798 443218011901 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443218011902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218011904 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 443218011905 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443218011906 NAD binding site [chemical binding]; other site 443218011907 homodimer interface [polypeptide binding]; other site 443218011908 homotetramer interface [polypeptide binding]; other site 443218011909 active site 443218011910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443218011911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011912 S-adenosylmethionine binding site [chemical binding]; other site 443218011913 Protein of unknown function (DUF779); Region: DUF779; pfam05610 443218011914 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 443218011915 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218011916 NAD(P) binding site [chemical binding]; other site 443218011917 catalytic residues [active] 443218011918 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 443218011919 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218011920 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 443218011921 putative NAD(P) binding site [chemical binding]; other site 443218011922 catalytic Zn binding site [ion binding]; other site 443218011923 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218011924 Predicted membrane protein [Function unknown]; Region: COG1511 443218011925 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443218011926 Predicted membrane protein [Function unknown]; Region: COG1511 443218011927 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218011928 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443218011929 Transcriptional regulator PadR-like family; Region: PadR; cl17335 443218011930 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218011931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218011932 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218011933 Walker A/P-loop; other site 443218011934 ATP binding site [chemical binding]; other site 443218011935 Q-loop/lid; other site 443218011936 ABC transporter signature motif; other site 443218011937 Walker B; other site 443218011938 D-loop; other site 443218011939 H-loop/switch region; other site 443218011940 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218011941 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218011942 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218011943 Amidase; Region: Amidase; cl11426 443218011944 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 443218011945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218011946 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443218011947 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 443218011948 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218011949 carboxyltransferase (CT) interaction site; other site 443218011950 biotinylation site [posttranslational modification]; other site 443218011951 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 443218011952 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 443218011953 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443218011954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011955 active site 443218011956 phosphorylation site [posttranslational modification] 443218011957 intermolecular recognition site; other site 443218011958 dimerization interface [polypeptide binding]; other site 443218011959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218011960 DNA binding site [nucleotide binding] 443218011961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218011962 phosphorylation site [posttranslational modification] 443218011963 dimer interface [polypeptide binding]; other site 443218011964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218011965 ATP binding site [chemical binding]; other site 443218011966 Mg2+ binding site [ion binding]; other site 443218011967 G-X-G motif; other site 443218011968 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 443218011969 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 443218011970 Ion transport protein; Region: Ion_trans; pfam00520 443218011971 hypothetical protein; Provisional; Region: PRK07907 443218011972 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 443218011973 metal binding site [ion binding]; metal-binding site 443218011974 putative dimer interface [polypeptide binding]; other site 443218011975 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443218011976 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 443218011977 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443218011978 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218011979 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218011980 catalytic residue [active] 443218011981 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443218011982 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218011983 NAD(P) binding site [chemical binding]; other site 443218011984 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 443218011985 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 443218011986 active site 443218011987 zinc binding site [ion binding]; other site 443218011988 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 443218011989 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 443218011990 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 443218011991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218011992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218011993 Walker A/P-loop; other site 443218011994 ATP binding site [chemical binding]; other site 443218011995 Q-loop/lid; other site 443218011996 ABC transporter signature motif; other site 443218011997 Walker B; other site 443218011998 D-loop; other site 443218011999 H-loop/switch region; other site 443218012000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443218012001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218012002 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218012003 Walker A/P-loop; other site 443218012004 ATP binding site [chemical binding]; other site 443218012005 Q-loop/lid; other site 443218012006 ABC transporter signature motif; other site 443218012007 Walker B; other site 443218012008 D-loop; other site 443218012009 H-loop/switch region; other site 443218012010 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443218012011 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218012012 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443218012013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443218012014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218012015 catalytic residue [active] 443218012016 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 443218012017 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 443218012018 TrwC relaxase; Region: TrwC; pfam08751 443218012019 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218012020 AAA domain; Region: AAA_30; pfam13604 443218012021 Family description; Region: UvrD_C_2; pfam13538 443218012022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218012023 non-specific DNA binding site [nucleotide binding]; other site 443218012024 salt bridge; other site 443218012025 sequence-specific DNA binding site [nucleotide binding]; other site 443218012026 Domain of unknown function (DUF955); Region: DUF955; cl01076 443218012027 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 443218012028 AAA domain; Region: AAA_30; pfam13604 443218012029 Family description; Region: UvrD_C_2; pfam13538 443218012030 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443218012031 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 443218012032 Lsr2; Region: Lsr2; pfam11774 443218012033 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218012034 Helix-turn-helix domain; Region: HTH_38; pfam13936 443218012035 Integrase core domain; Region: rve; pfam00665 443218012036 Lsr2; Region: Lsr2; pfam11774 443218012037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012038 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218012039 CoenzymeA binding site [chemical binding]; other site 443218012040 subunit interaction site [polypeptide binding]; other site 443218012041 PHB binding site; other site 443218012042 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218012043 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218012044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218012045 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443218012046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218012047 catalytic loop [active] 443218012048 iron binding site [ion binding]; other site 443218012049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218012050 Cytochrome P450; Region: p450; cl12078 443218012051 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218012052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218012053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218012054 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 443218012055 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443218012056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218012058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443218012059 MULE transposase domain; Region: MULE; pfam10551 443218012060 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443218012061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218012062 motif II; other site 443218012063 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443218012064 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443218012065 Cytochrome P450; Region: p450; cl12078 443218012066 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443218012067 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218012068 catalytic residues [active] 443218012069 catalytic nucleophile [active] 443218012070 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218012071 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218012072 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218012073 Synaptic Site I dimer interface [polypeptide binding]; other site 443218012074 DNA binding site [nucleotide binding] 443218012075 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218012076 DNA-binding interface [nucleotide binding]; DNA binding site 443218012077 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 443218012078 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 443218012079 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 443218012080 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 443218012081 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 443218012082 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443218012083 putative active site [active] 443218012084 HlyD family secretion protein; Region: HlyD_3; pfam13437 443218012085 AAA ATPase domain; Region: AAA_16; pfam13191 443218012086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218012087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218012088 DNA binding residues [nucleotide binding] 443218012089 dimerization interface [polypeptide binding]; other site 443218012090 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 443218012091 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443218012092 active site 443218012093 NAD binding site [chemical binding]; other site 443218012094 metal binding site [ion binding]; metal-binding site 443218012095 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218012096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218012097 Walker A motif; other site 443218012098 ATP binding site [chemical binding]; other site 443218012099 Walker B motif; other site 443218012100 arginine finger; other site 443218012101 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 443218012102 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 443218012103 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218012104 metal ion-dependent adhesion site (MIDAS); other site 443218012105 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443218012106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218012107 S-adenosylmethionine binding site [chemical binding]; other site 443218012108 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443218012109 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443218012110 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218012111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218012112 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218012113 FAD binding site [chemical binding]; other site 443218012114 homotetramer interface [polypeptide binding]; other site 443218012115 substrate binding pocket [chemical binding]; other site 443218012116 catalytic base [active] 443218012117 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218012118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012119 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 443218012120 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 443218012121 Na binding site [ion binding]; other site 443218012122 putative substrate binding site [chemical binding]; other site 443218012123 Predicted membrane protein [Function unknown]; Region: COG1288 443218012124 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 443218012125 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218012126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218012127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218012128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218012129 active site 443218012130 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443218012131 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218012132 FMN binding site [chemical binding]; other site 443218012133 substrate binding site [chemical binding]; other site 443218012134 putative catalytic residue [active] 443218012135 enoyl-CoA hydratase; Provisional; Region: PRK08260 443218012136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218012137 substrate binding site [chemical binding]; other site 443218012138 oxyanion hole (OAH) forming residues; other site 443218012139 trimer interface [polypeptide binding]; other site 443218012140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218012141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012143 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218012144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218012145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218012146 active site 443218012147 phosphorylation site [posttranslational modification] 443218012148 intermolecular recognition site; other site 443218012149 dimerization interface [polypeptide binding]; other site 443218012150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218012151 DNA binding residues [nucleotide binding] 443218012152 dimerization interface [polypeptide binding]; other site 443218012153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218012154 Histidine kinase; Region: HisKA_3; pfam07730 443218012155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218012156 ATP binding site [chemical binding]; other site 443218012157 Mg2+ binding site [ion binding]; other site 443218012158 G-X-G motif; other site 443218012159 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443218012160 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443218012161 active site 443218012162 NAD binding site [chemical binding]; other site 443218012163 metal binding site [ion binding]; metal-binding site 443218012164 mycofactocin precursor; Region: mycofactocin; TIGR03969 443218012165 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443218012166 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443218012167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218012168 FeS/SAM binding site; other site 443218012169 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443218012170 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443218012171 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218012172 phosphate binding site [ion binding]; other site 443218012173 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443218012174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218012175 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218012176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443218012177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218012178 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443218012179 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218012180 anti sigma factor interaction site; other site 443218012181 regulatory phosphorylation site [posttranslational modification]; other site 443218012182 GAF domain; Region: GAF; pfam01590 443218012183 GAF domain; Region: GAF_2; pfam13185 443218012184 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443218012185 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 443218012186 active site 443218012187 EXLDI protein; Region: EXLDI; TIGR04342 443218012188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218012189 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218012190 Walker A/P-loop; other site 443218012191 ATP binding site [chemical binding]; other site 443218012192 Q-loop/lid; other site 443218012193 ABC transporter signature motif; other site 443218012194 Walker B; other site 443218012195 D-loop; other site 443218012196 H-loop/switch region; other site 443218012197 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443218012198 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443218012199 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 443218012200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218012201 acyl-activating enzyme (AAE) consensus motif; other site 443218012202 AMP binding site [chemical binding]; other site 443218012203 active site 443218012204 CoA binding site [chemical binding]; other site 443218012205 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443218012206 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443218012207 putative active site [active] 443218012208 putative catalytic site [active] 443218012209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218012210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218012211 active site 443218012212 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218012213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218012214 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443218012215 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443218012216 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218012217 carboxyltransferase (CT) interaction site; other site 443218012218 biotinylation site [posttranslational modification]; other site 443218012219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218012220 UMP phosphatase; Provisional; Region: PRK10444 443218012221 active site 443218012222 motif I; other site 443218012223 motif II; other site 443218012224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218012225 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 443218012226 amphipathic channel; other site 443218012227 Asn-Pro-Ala signature motifs; other site 443218012228 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218012229 glycerol kinase; Provisional; Region: glpK; PRK00047 443218012230 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 443218012231 N- and C-terminal domain interface [polypeptide binding]; other site 443218012232 active site 443218012233 MgATP binding site [chemical binding]; other site 443218012234 catalytic site [active] 443218012235 metal binding site [ion binding]; metal-binding site 443218012236 putative homotetramer interface [polypeptide binding]; other site 443218012237 glycerol binding site [chemical binding]; other site 443218012238 homodimer interface [polypeptide binding]; other site 443218012239 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443218012240 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218012241 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218012242 glycerol kinase; Region: glycerol_kin; TIGR01311 443218012243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218012244 nucleotide binding site [chemical binding]; other site 443218012245 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 443218012246 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443218012247 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443218012248 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443218012249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012251 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443218012252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218012253 active site 443218012254 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443218012255 classical (c) SDRs; Region: SDR_c; cd05233 443218012256 NAD(P) binding site [chemical binding]; other site 443218012257 active site 443218012258 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 443218012259 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443218012260 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443218012261 phosphate binding site [ion binding]; other site 443218012262 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443218012263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218012264 FeS/SAM binding site; other site 443218012265 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443218012266 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443218012267 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218012268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012269 AMP-binding domain protein; Validated; Region: PRK08315 443218012270 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443218012271 acyl-activating enzyme (AAE) consensus motif; other site 443218012272 putative AMP binding site [chemical binding]; other site 443218012273 putative active site [active] 443218012274 putative CoA binding site [chemical binding]; other site 443218012275 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 443218012276 Na2 binding site [ion binding]; other site 443218012277 putative substrate binding site 1 [chemical binding]; other site 443218012278 Na binding site 1 [ion binding]; other site 443218012279 putative substrate binding site 2 [chemical binding]; other site 443218012280 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218012281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218012282 putative DNA binding site [nucleotide binding]; other site 443218012283 putative Zn2+ binding site [ion binding]; other site 443218012284 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218012285 MIP family channel proteins; Region: MIP; TIGR00861 443218012286 amphipathic channel; other site 443218012287 Asn-Pro-Ala signature motifs; other site 443218012288 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 443218012289 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 443218012290 DAK2 domain; Region: Dak2; cl03685 443218012291 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 443218012292 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 443218012293 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443218012294 dimerization domain swap beta strand [polypeptide binding]; other site 443218012295 regulatory protein interface [polypeptide binding]; other site 443218012296 active site 443218012297 regulatory phosphorylation site [posttranslational modification]; other site 443218012298 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218012299 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218012300 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443218012301 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443218012302 short chain dehydrogenase; Provisional; Region: PRK05866 443218012303 classical (c) SDRs; Region: SDR_c; cd05233 443218012304 NAD(P) binding site [chemical binding]; other site 443218012305 active site 443218012306 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218012307 cyclase homology domain; Region: CHD; cd07302 443218012308 nucleotidyl binding site; other site 443218012309 metal binding site [ion binding]; metal-binding site 443218012310 dimer interface [polypeptide binding]; other site 443218012311 H+ Antiporter protein; Region: 2A0121; TIGR00900 443218012312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218012313 putative substrate translocation pore; other site 443218012314 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218012315 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443218012316 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 443218012317 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443218012318 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 443218012319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218012320 dimerization interface [polypeptide binding]; other site 443218012321 putative DNA binding site [nucleotide binding]; other site 443218012322 putative Zn2+ binding site [ion binding]; other site 443218012323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443218012324 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443218012325 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443218012326 NAD binding site [chemical binding]; other site 443218012327 catalytic Zn binding site [ion binding]; other site 443218012328 substrate binding site [chemical binding]; other site 443218012329 structural Zn binding site [ion binding]; other site 443218012330 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218012331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218012332 NAD(P) binding site [chemical binding]; other site 443218012333 active site 443218012334 Predicted transcriptional regulators [Transcription]; Region: COG1733 443218012335 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443218012336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218012337 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443218012338 Walker A/P-loop; other site 443218012339 ATP binding site [chemical binding]; other site 443218012340 Q-loop/lid; other site 443218012341 ABC transporter signature motif; other site 443218012342 Walker B; other site 443218012343 D-loop; other site 443218012344 H-loop/switch region; other site 443218012345 TOBE domain; Region: TOBE_2; pfam08402 443218012346 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218012348 dimer interface [polypeptide binding]; other site 443218012349 conserved gate region; other site 443218012350 putative PBP binding loops; other site 443218012351 ABC-ATPase subunit interface; other site 443218012352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218012353 dimer interface [polypeptide binding]; other site 443218012354 conserved gate region; other site 443218012355 putative PBP binding loops; other site 443218012356 ABC-ATPase subunit interface; other site 443218012357 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218012358 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218012359 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 443218012360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218012361 DNA binding residues [nucleotide binding] 443218012362 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 443218012363 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218012364 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 443218012365 inhibitor binding site; inhibition site 443218012366 catalytic Zn binding site [ion binding]; other site 443218012367 structural Zn binding site [ion binding]; other site 443218012368 NADP binding site [chemical binding]; other site 443218012369 tetramer interface [polypeptide binding]; other site 443218012370 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 443218012371 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 443218012372 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 443218012373 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218012374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443218012375 nucleotide binding site [chemical binding]; other site 443218012376 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218012377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218012378 non-specific DNA binding site [nucleotide binding]; other site 443218012379 salt bridge; other site 443218012380 sequence-specific DNA binding site [nucleotide binding]; other site 443218012381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012383 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443218012384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218012385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218012386 active site 443218012387 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218012388 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 443218012389 DNA binding residues [nucleotide binding] 443218012390 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218012391 dimer interface [polypeptide binding]; other site 443218012392 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 443218012393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218012394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218012395 active site 443218012396 phosphorylation site [posttranslational modification] 443218012397 intermolecular recognition site; other site 443218012398 dimerization interface [polypeptide binding]; other site 443218012399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218012400 DNA binding residues [nucleotide binding] 443218012401 dimerization interface [polypeptide binding]; other site 443218012402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218012403 Histidine kinase; Region: HisKA_3; pfam07730 443218012404 Small T antigen; Reviewed; Region: PHA03102 443218012405 CsbD-like; Region: CsbD; pfam05532 443218012406 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443218012407 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443218012408 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218012409 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218012410 FMN-binding pocket [chemical binding]; other site 443218012411 flavin binding motif; other site 443218012412 phosphate binding motif [ion binding]; other site 443218012413 beta-alpha-beta structure motif; other site 443218012414 NAD binding pocket [chemical binding]; other site 443218012415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218012416 catalytic loop [active] 443218012417 iron binding site [ion binding]; other site 443218012418 hypothetical protein; Provisional; Region: PRK07945 443218012419 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443218012420 active site 443218012421 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 443218012422 Response regulator receiver domain; Region: Response_reg; pfam00072 443218012423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218012424 active site 443218012425 phosphorylation site [posttranslational modification] 443218012426 intermolecular recognition site; other site 443218012427 dimerization interface [polypeptide binding]; other site 443218012428 FOG: CBS domain [General function prediction only]; Region: COG0517 443218012429 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 443218012430 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218012431 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443218012432 NAD(P) binding site [chemical binding]; other site 443218012433 GXWXG protein; Region: GXWXG; pfam14231 443218012434 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 443218012435 peptide synthase; Provisional; Region: PRK12316 443218012436 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012437 acyl-activating enzyme (AAE) consensus motif; other site 443218012438 AMP binding site [chemical binding]; other site 443218012439 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218012440 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218012441 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218012442 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012443 acyl-activating enzyme (AAE) consensus motif; other site 443218012444 AMP binding site [chemical binding]; other site 443218012445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218012446 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012447 acyl-activating enzyme (AAE) consensus motif; other site 443218012448 AMP binding site [chemical binding]; other site 443218012449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218012450 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218012451 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012452 acyl-activating enzyme (AAE) consensus motif; other site 443218012453 AMP binding site [chemical binding]; other site 443218012454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218012455 Condensation domain; Region: Condensation; pfam00668 443218012456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218012457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012458 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443218012459 acyl-activating enzyme (AAE) consensus motif; other site 443218012460 AMP binding site [chemical binding]; other site 443218012461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218012462 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218012463 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218012464 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443218012465 acyl-activating enzyme (AAE) consensus motif; other site 443218012466 AMP binding site [chemical binding]; other site 443218012467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443218012468 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 443218012469 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443218012470 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 443218012471 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443218012472 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443218012473 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 443218012474 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443218012475 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443218012476 putative dimer interface [polypeptide binding]; other site 443218012477 [2Fe-2S] cluster binding site [ion binding]; other site 443218012478 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 443218012479 SLBB domain; Region: SLBB; pfam10531 443218012480 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 443218012481 NADH dehydrogenase subunit G; Validated; Region: PRK07860 443218012482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218012483 catalytic loop [active] 443218012484 iron binding site [ion binding]; other site 443218012485 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 443218012486 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218012487 molybdopterin cofactor binding site; other site 443218012488 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 443218012489 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443218012490 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443218012491 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 443218012492 4Fe-4S binding domain; Region: Fer4; pfam00037 443218012493 4Fe-4S binding domain; Region: Fer4; pfam00037 443218012494 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443218012495 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 443218012496 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443218012497 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443218012498 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218012499 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218012500 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443218012501 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218012502 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443218012503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443218012504 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218012505 cyclase homology domain; Region: CHD; cd07302 443218012506 nucleotidyl binding site; other site 443218012507 metal binding site [ion binding]; metal-binding site 443218012508 dimer interface [polypeptide binding]; other site 443218012509 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218012510 cyclase homology domain; Region: CHD; cd07302 443218012511 nucleotidyl binding site; other site 443218012512 metal binding site [ion binding]; metal-binding site 443218012513 dimer interface [polypeptide binding]; other site 443218012514 Clp amino terminal domain; Region: Clp_N; pfam02861 443218012515 Clp amino terminal domain; Region: Clp_N; pfam02861 443218012516 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443218012517 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443218012518 TrkA-N domain; Region: TrkA_N; pfam02254 443218012519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218012520 putative DNA binding site [nucleotide binding]; other site 443218012521 putative Zn2+ binding site [ion binding]; other site 443218012522 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 443218012523 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218012524 DNA binding residues [nucleotide binding] 443218012525 cyclase homology domain; Region: CHD; cd07302 443218012526 nucleotidyl binding site; other site 443218012527 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218012528 metal binding site [ion binding]; metal-binding site 443218012529 dimer interface [polypeptide binding]; other site 443218012530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218012531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218012532 active site 443218012533 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218012534 active site 2 [active] 443218012535 active site 1 [active] 443218012536 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218012537 active site 2 [active] 443218012538 active site 1 [active] 443218012539 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 443218012540 short chain dehydrogenase; Provisional; Region: PRK08278 443218012541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218012542 NAD(P) binding site [chemical binding]; other site 443218012543 active site 443218012544 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218012545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218012546 substrate binding site [chemical binding]; other site 443218012547 trimer interface [polypeptide binding]; other site 443218012548 oxyanion hole (OAH) forming residues; other site 443218012549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218012550 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218012551 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218012552 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 443218012553 acyl-activating enzyme (AAE) consensus motif; other site 443218012554 putative AMP binding site [chemical binding]; other site 443218012555 putative active site [active] 443218012556 putative CoA binding site [chemical binding]; other site 443218012557 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443218012558 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218012559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218012560 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443218012561 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 443218012562 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443218012563 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 443218012564 AAA ATPase domain; Region: AAA_16; pfam13191 443218012565 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218012566 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218012567 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 443218012568 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443218012569 putative active site [active] 443218012570 putative FMN binding site [chemical binding]; other site 443218012571 putative substrate binding site [chemical binding]; other site 443218012572 putative catalytic residue [active] 443218012573 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218012574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012575 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218012576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218012577 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218012578 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218012579 putative di-iron ligands [ion binding]; other site 443218012580 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218012581 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 443218012582 FAD binding pocket [chemical binding]; other site 443218012583 conserved FAD binding motif [chemical binding]; other site 443218012584 phosphate binding motif [ion binding]; other site 443218012585 beta-alpha-beta structure motif; other site 443218012586 NAD binding pocket [chemical binding]; other site 443218012587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218012588 catalytic loop [active] 443218012589 iron binding site [ion binding]; other site 443218012590 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443218012591 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 443218012592 putative active site [active] 443218012593 metal binding site [ion binding]; metal-binding site 443218012594 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218012595 classical (c) SDRs; Region: SDR_c; cd05233 443218012596 NAD(P) binding site [chemical binding]; other site 443218012597 active site 443218012598 AAA ATPase domain; Region: AAA_16; pfam13191 443218012599 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 443218012600 short chain dehydrogenase; Provisional; Region: PRK07825 443218012601 classical (c) SDRs; Region: SDR_c; cd05233 443218012602 NAD(P) binding site [chemical binding]; other site 443218012603 active site 443218012604 GAF domain; Region: GAF; pfam01590 443218012605 GAF domain; Region: GAF_2; pfam13185 443218012606 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443218012607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 443218012608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 443218012609 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 443218012610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 443218012611 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 443218012612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443218012613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218012614 ATP binding site [chemical binding]; other site 443218012615 Mg2+ binding site [ion binding]; other site 443218012616 G-X-G motif; other site 443218012617 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443218012618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218012619 active site 443218012620 phosphorylation site [posttranslational modification] 443218012621 intermolecular recognition site; other site 443218012622 dimerization interface [polypeptide binding]; other site 443218012623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218012624 NAD(P) binding site [chemical binding]; other site 443218012625 active site 443218012626 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218012627 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443218012628 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218012629 short chain dehydrogenase; Provisional; Region: PRK07201 443218012630 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 443218012631 putative NAD(P) binding site [chemical binding]; other site 443218012632 active site 443218012633 putative substrate binding site [chemical binding]; other site 443218012634 classical (c) SDRs; Region: SDR_c; cd05233 443218012635 NAD(P) binding site [chemical binding]; other site 443218012636 active site 443218012637 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443218012638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443218012639 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443218012640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218012641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443218012642 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 443218012643 dimerization interface [polypeptide binding]; other site 443218012644 substrate binding pocket [chemical binding]; other site 443218012645 short chain dehydrogenase; Provisional; Region: PRK12744 443218012646 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 443218012647 NADP binding site [chemical binding]; other site 443218012648 homodimer interface [polypeptide binding]; other site 443218012649 active site 443218012650 substrate binding site [chemical binding]; other site 443218012651 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 443218012652 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 443218012653 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443218012654 acyl-CoA synthetase; Validated; Region: PRK07788 443218012655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218012656 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443218012657 active site 443218012658 CoA binding site [chemical binding]; other site 443218012659 AMP binding site [chemical binding]; other site 443218012660 Secretory lipase; Region: LIP; pfam03583 443218012661 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443218012662 DinB superfamily; Region: DinB_2; pfam12867 443218012663 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 443218012664 putative hydrophobic ligand binding site [chemical binding]; other site 443218012665 aconitate hydratase; Validated; Region: PRK07229 443218012666 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443218012667 substrate binding site [chemical binding]; other site 443218012668 ligand binding site [chemical binding]; other site 443218012669 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 443218012670 substrate binding site [chemical binding]; other site 443218012671 Predicted membrane protein [Function unknown]; Region: COG4763 443218012672 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443218012673 Glutaminase; Region: Glutaminase; cl00907 443218012674 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 443218012675 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218012676 MarR family; Region: MarR; pfam01047 443218012677 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 443218012678 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 443218012679 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 443218012680 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 443218012681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443218012682 Walker A/P-loop; other site 443218012683 ATP binding site [chemical binding]; other site 443218012684 Q-loop/lid; other site 443218012685 ABC transporter signature motif; other site 443218012686 Walker B; other site 443218012687 D-loop; other site 443218012688 H-loop/switch region; other site 443218012689 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443218012690 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 443218012691 homotrimer interaction site [polypeptide binding]; other site 443218012692 putative active site [active] 443218012693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443218012694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218012695 Coenzyme A binding pocket [chemical binding]; other site 443218012696 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443218012697 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218012698 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443218012699 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218012700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218012701 dimerization interface [polypeptide binding]; other site 443218012702 putative DNA binding site [nucleotide binding]; other site 443218012703 putative Zn2+ binding site [ion binding]; other site 443218012704 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443218012705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443218012706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218012707 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218012708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218012709 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443218012710 YCII-related domain; Region: YCII; cl00999 443218012711 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443218012712 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 443218012713 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 443218012714 NAD(P) binding site [chemical binding]; other site 443218012715 LDH/MDH dimer interface [polypeptide binding]; other site 443218012716 substrate binding site [chemical binding]; other site 443218012717 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218012718 CoenzymeA binding site [chemical binding]; other site 443218012719 subunit interaction site [polypeptide binding]; other site 443218012720 PHB binding site; other site 443218012721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443218012723 Cupin domain; Region: Cupin_2; pfam07883 443218012724 replicative DNA helicase; Provisional; Region: PRK05636 443218012725 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443218012726 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443218012727 Walker A motif; other site 443218012728 ATP binding site [chemical binding]; other site 443218012729 Walker B motif; other site 443218012730 DNA binding loops [nucleotide binding] 443218012731 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443218012732 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443218012733 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443218012734 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 443218012735 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443218012736 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443218012737 dimer interface [polypeptide binding]; other site 443218012738 ssDNA binding site [nucleotide binding]; other site 443218012739 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443218012740 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 443218012741 endonuclease IV; Provisional; Region: PRK01060 443218012742 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443218012743 AP (apurinic/apyrimidinic) site pocket; other site 443218012744 DNA interaction; other site 443218012745 Metal-binding active site; metal-binding site 443218012746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218012747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218012748 DNA binding residues [nucleotide binding] 443218012749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218012750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218012751 ATP binding site [chemical binding]; other site 443218012752 Mg2+ binding site [ion binding]; other site 443218012753 G-X-G motif; other site 443218012754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 443218012755 DNA binding residues [nucleotide binding] 443218012756 dimerization interface [polypeptide binding]; other site 443218012757 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218012758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218012759 DNA binding residues [nucleotide binding] 443218012760 Proline dehydrogenase; Region: Pro_dh; cl03282 443218012761 Predicted integral membrane protein [Function unknown]; Region: COG5650 443218012762 Transglycosylase; Region: Transgly; pfam00912 443218012763 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443218012764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443218012765 Predicted transcriptional regulators [Transcription]; Region: COG1695 443218012766 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443218012767 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 443218012768 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 443218012769 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 443218012770 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 443218012771 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218012772 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218012773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218012774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218012775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218012776 dimer interface [polypeptide binding]; other site 443218012777 conserved gate region; other site 443218012778 putative PBP binding loops; other site 443218012779 ABC-ATPase subunit interface; other site 443218012780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218012781 dimer interface [polypeptide binding]; other site 443218012782 conserved gate region; other site 443218012783 putative PBP binding loops; other site 443218012784 ABC-ATPase subunit interface; other site 443218012785 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443218012786 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218012787 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 443218012788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443218012789 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218012790 short chain dehydrogenase; Provisional; Region: PRK08219 443218012791 classical (c) SDRs; Region: SDR_c; cd05233 443218012792 NAD(P) binding site [chemical binding]; other site 443218012793 active site 443218012794 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443218012795 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012796 active site 443218012797 HIGH motif; other site 443218012798 nucleotide binding site [chemical binding]; other site 443218012799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443218012800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012801 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012802 active site 443218012803 KMSKS motif; other site 443218012804 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443218012805 tRNA binding surface [nucleotide binding]; other site 443218012806 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443218012807 SdpI/YhfL protein family; Region: SdpI; pfam13630 443218012808 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218012809 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218012810 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 443218012811 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 443218012812 L-lysine aminotransferase; Provisional; Region: PRK08297 443218012813 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218012814 inhibitor-cofactor binding pocket; inhibition site 443218012815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218012816 catalytic residue [active] 443218012817 hypothetical protein; Validated; Region: PRK00228 443218012818 H+ Antiporter protein; Region: 2A0121; TIGR00900 443218012819 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443218012820 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443218012821 active site 443218012822 NTP binding site [chemical binding]; other site 443218012823 metal binding triad [ion binding]; metal-binding site 443218012824 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443218012825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443218012826 Zn2+ binding site [ion binding]; other site 443218012827 Mg2+ binding site [ion binding]; other site 443218012828 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443218012829 active site 443218012830 metal binding site [ion binding]; metal-binding site 443218012831 Ap6A binding site [chemical binding]; other site 443218012832 integral membrane protein MviN; Region: mviN; TIGR01695 443218012833 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443218012834 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 443218012835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218012836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218012837 DNA binding residues [nucleotide binding] 443218012838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012839 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218012840 DNA-binding interface [nucleotide binding]; DNA binding site 443218012841 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443218012842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443218012843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218012844 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218012845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443218012846 catalytic residues [active] 443218012847 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 443218012848 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443218012849 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443218012850 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443218012851 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443218012852 active site 443218012853 metal binding site [ion binding]; metal-binding site 443218012854 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 443218012855 ParB-like nuclease domain; Region: ParB; smart00470 443218012856 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218012857 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218012858 Magnesium ion binding site [ion binding]; other site 443218012859 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 443218012860 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443218012861 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 443218012862 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443218012863 G-X-X-G motif; other site 443218012864 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443218012865 RxxxH motif; other site 443218012866 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 443218012867 Haemolytic domain; Region: Haemolytic; cl00506 443218012868 Ribosomal protein L34; Region: Ribosomal_L34; cl00370