-- dump date 20140618_203409 -- class Genbank::misc_feature -- table misc_feature_note -- id note 46234000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 46234000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 46234000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234000004 Walker A motif; other site 46234000005 ATP binding site [chemical binding]; other site 46234000006 Walker B motif; other site 46234000007 arginine finger; other site 46234000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 46234000009 DnaA box-binding interface [nucleotide binding]; other site 46234000010 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 46234000011 nucleoside/Zn binding site; other site 46234000012 dimer interface [polypeptide binding]; other site 46234000013 catalytic motif [active] 46234000014 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 46234000015 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234000016 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234000017 active site 46234000018 XisI protein; Region: XisI; pfam08869 46234000019 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234000020 YcfA-like protein; Region: YcfA; pfam07927 46234000021 DNA methylase; Region: N6_N4_Mtase; cl17433 46234000022 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234000023 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 46234000024 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 46234000025 homotetramer interface [polypeptide binding]; other site 46234000026 ligand binding site [chemical binding]; other site 46234000027 catalytic site [active] 46234000028 NAD binding site [chemical binding]; other site 46234000029 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 46234000030 Mechanosensitive ion channel; Region: MS_channel; pfam00924 46234000031 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234000032 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234000033 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 46234000034 Response regulator receiver domain; Region: Response_reg; pfam00072 46234000035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000036 active site 46234000037 phosphorylation site [posttranslational modification] 46234000038 intermolecular recognition site; other site 46234000039 dimerization interface [polypeptide binding]; other site 46234000040 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 46234000041 metal ion-dependent adhesion site (MIDAS); other site 46234000042 Protein phosphatase 2C; Region: PP2C_2; pfam13672 46234000043 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 46234000044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 46234000045 active site 46234000046 ATP binding site [chemical binding]; other site 46234000047 substrate binding site [chemical binding]; other site 46234000048 activation loop (A-loop); other site 46234000049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000050 binding surface 46234000051 TPR repeat; Region: TPR_11; pfam13414 46234000052 TPR motif; other site 46234000053 TPR repeat; Region: TPR_11; pfam13414 46234000054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000055 TPR motif; other site 46234000056 TPR repeat; Region: TPR_11; pfam13414 46234000057 binding surface 46234000058 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 46234000059 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 46234000060 substrate binding site; other site 46234000061 Predicted dehydrogenase [General function prediction only]; Region: COG0579 46234000062 hydroxyglutarate oxidase; Provisional; Region: PRK11728 46234000063 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 46234000064 extended (e) SDRs; Region: SDR_e; cd08946 46234000065 NAD(P) binding site [chemical binding]; other site 46234000066 active site 46234000067 substrate binding site [chemical binding]; other site 46234000068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234000069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234000070 active site 46234000071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234000072 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 46234000073 active site 46234000074 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 46234000075 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 46234000076 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 46234000077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 46234000078 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 46234000079 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234000080 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 46234000081 putative ADP-binding pocket [chemical binding]; other site 46234000082 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 46234000083 Chain length determinant protein; Region: Wzz; cl15801 46234000084 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 46234000085 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 46234000086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234000087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234000088 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 46234000089 Walker A/P-loop; other site 46234000090 ATP binding site [chemical binding]; other site 46234000091 Q-loop/lid; other site 46234000092 ABC transporter signature motif; other site 46234000093 Walker B; other site 46234000094 D-loop; other site 46234000095 H-loop/switch region; other site 46234000096 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234000097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234000098 active site 46234000099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234000100 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234000101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234000102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234000103 active site 46234000104 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 46234000105 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 46234000106 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 46234000107 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 46234000108 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 46234000109 active site 46234000110 Zn binding site [ion binding]; other site 46234000111 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234000112 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234000113 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234000114 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234000115 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 46234000116 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234000117 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234000118 structural tetrad; other site 46234000119 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234000120 putative active site [active] 46234000121 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 46234000122 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 46234000123 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 46234000124 dimer interface [polypeptide binding]; other site 46234000125 motif 1; other site 46234000126 active site 46234000127 motif 2; other site 46234000128 motif 3; other site 46234000129 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 46234000130 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 46234000131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234000132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234000133 active site 46234000134 ATP binding site [chemical binding]; other site 46234000135 substrate binding site [chemical binding]; other site 46234000136 activation loop (A-loop); other site 46234000137 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234000138 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234000139 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 46234000140 Response regulator receiver domain; Region: Response_reg; pfam00072 46234000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000142 active site 46234000143 phosphorylation site [posttranslational modification] 46234000144 intermolecular recognition site; other site 46234000145 dimerization interface [polypeptide binding]; other site 46234000146 polyphosphate kinase; Provisional; Region: PRK05443 46234000147 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 46234000148 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 46234000149 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 46234000150 putative domain interface [polypeptide binding]; other site 46234000151 putative active site [active] 46234000152 catalytic site [active] 46234000153 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 46234000154 putative domain interface [polypeptide binding]; other site 46234000155 putative active site [active] 46234000156 catalytic site [active] 46234000157 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234000158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234000159 active site 46234000160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234000161 dimer interface [polypeptide binding]; other site 46234000162 phosphorylation site [posttranslational modification] 46234000163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234000164 ATP binding site [chemical binding]; other site 46234000165 Mg2+ binding site [ion binding]; other site 46234000166 G-X-G motif; other site 46234000167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000168 binding surface 46234000169 TPR motif; other site 46234000170 TPR repeat; Region: TPR_11; pfam13414 46234000171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000172 TPR repeat; Region: TPR_11; pfam13414 46234000173 binding surface 46234000174 TPR motif; other site 46234000175 TPR repeat; Region: TPR_11; pfam13414 46234000176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234000177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000178 active site 46234000179 phosphorylation site [posttranslational modification] 46234000180 intermolecular recognition site; other site 46234000181 dimerization interface [polypeptide binding]; other site 46234000182 DNA gyrase subunit A; Validated; Region: PRK05560 46234000183 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 46234000184 CAP-like domain; other site 46234000185 active site 46234000186 primary dimer interface [polypeptide binding]; other site 46234000187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234000188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234000189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234000190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234000191 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 46234000192 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 46234000193 putative sugar binding sites [chemical binding]; other site 46234000194 Q-X-W motif; other site 46234000195 AAA ATPase domain; Region: AAA_16; pfam13191 46234000196 AAA domain; Region: AAA_22; pfam13401 46234000197 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234000198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000199 binding surface 46234000200 TPR motif; other site 46234000201 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234000202 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234000203 YcfA-like protein; Region: YcfA; cl00752 46234000204 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 46234000205 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 46234000206 light-harvesting-like protein 3; Provisional; Region: PLN00014 46234000207 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 46234000208 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 46234000209 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 46234000210 inhibitor-cofactor binding pocket; inhibition site 46234000211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234000212 catalytic residue [active] 46234000213 Protein of unknown function (DUF561); Region: DUF561; pfam04481 46234000214 Rubrerythrin [Energy production and conversion]; Region: COG1592 46234000215 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 46234000216 binuclear metal center [ion binding]; other site 46234000217 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 46234000218 iron binding site [ion binding]; other site 46234000219 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 46234000220 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 46234000221 NAD(P) binding site [chemical binding]; other site 46234000222 catalytic residues [active] 46234000223 Caspase domain; Region: Peptidase_C14; pfam00656 46234000224 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 46234000225 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 46234000226 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 46234000227 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 46234000228 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 46234000229 dihydrodipicolinate synthase; Region: dapA; TIGR00674 46234000230 dimer interface [polypeptide binding]; other site 46234000231 active site 46234000232 catalytic residue [active] 46234000233 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 46234000234 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 46234000235 trigger factor; Provisional; Region: tig; PRK01490 46234000236 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 46234000237 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 46234000238 Clp protease; Region: CLP_protease; pfam00574 46234000239 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 46234000240 oligomer interface [polypeptide binding]; other site 46234000241 active site residues [active] 46234000242 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 46234000243 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 46234000244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234000245 Walker A motif; other site 46234000246 ATP binding site [chemical binding]; other site 46234000247 Walker B motif; other site 46234000248 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 46234000249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234000250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234000251 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 46234000252 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 46234000253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 46234000254 catalytic core [active] 46234000255 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 46234000256 catalytic core [active] 46234000257 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 46234000258 MltA specific insert domain; Region: MltA; pfam03562 46234000259 3D domain; Region: 3D; pfam06725 46234000260 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 46234000261 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 46234000262 active site 46234000263 intersubunit interface [polypeptide binding]; other site 46234000264 catalytic residue [active] 46234000265 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 46234000266 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 46234000267 MOSC domain; Region: MOSC; pfam03473 46234000268 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 46234000269 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 46234000270 Catalytic site [active] 46234000271 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 46234000272 dihydroorotase; Provisional; Region: PRK07575 46234000273 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 46234000274 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 46234000275 active site 46234000276 TPR repeat; Region: TPR_11; pfam13414 46234000277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000278 binding surface 46234000279 TPR motif; other site 46234000280 TPR repeat; Region: TPR_11; pfam13414 46234000281 TPR repeat; Region: TPR_11; pfam13414 46234000282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000283 binding surface 46234000284 TPR motif; other site 46234000285 TPR repeat; Region: TPR_11; pfam13414 46234000286 TPR repeat; Region: TPR_11; pfam13414 46234000287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000288 binding surface 46234000289 TPR motif; other site 46234000290 TPR repeat; Region: TPR_11; pfam13414 46234000291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000292 binding surface 46234000293 TPR motif; other site 46234000294 TPR repeat; Region: TPR_11; pfam13414 46234000295 TPR repeat; Region: TPR_11; pfam13414 46234000296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000297 binding surface 46234000298 TPR motif; other site 46234000299 TPR repeat; Region: TPR_11; pfam13414 46234000300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000301 binding surface 46234000302 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234000303 TPR motif; other site 46234000304 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234000305 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234000306 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 46234000307 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234000308 putative active site [active] 46234000309 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 46234000310 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 46234000311 putative substrate binding pocket [chemical binding]; other site 46234000312 dimer interface [polypeptide binding]; other site 46234000313 phosphate binding site [ion binding]; other site 46234000314 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 46234000315 active site 46234000316 putative DNA-binding cleft [nucleotide binding]; other site 46234000317 dimer interface [polypeptide binding]; other site 46234000318 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 46234000319 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 46234000320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234000321 ATP binding site [chemical binding]; other site 46234000322 putative Mg++ binding site [ion binding]; other site 46234000323 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 46234000324 Transposase IS200 like; Region: Y1_Tnp; pfam01797 46234000325 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 46234000326 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234000327 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 46234000328 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 46234000329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234000330 dimer interface [polypeptide binding]; other site 46234000331 conserved gate region; other site 46234000332 putative PBP binding loops; other site 46234000333 ABC-ATPase subunit interface; other site 46234000334 Predicted membrane protein [Function unknown]; Region: COG3431 46234000335 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 46234000336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 46234000337 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 46234000338 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 46234000339 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234000340 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 46234000341 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 46234000342 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 46234000343 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 46234000344 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234000345 putative active site [active] 46234000346 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 46234000347 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 46234000348 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234000349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000350 active site 46234000351 phosphorylation site [posttranslational modification] 46234000352 intermolecular recognition site; other site 46234000353 dimerization interface [polypeptide binding]; other site 46234000354 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 46234000355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234000356 putative active site [active] 46234000357 heme pocket [chemical binding]; other site 46234000358 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 46234000359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234000360 putative active site [active] 46234000361 heme pocket [chemical binding]; other site 46234000362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234000363 dimer interface [polypeptide binding]; other site 46234000364 phosphorylation site [posttranslational modification] 46234000365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234000366 ATP binding site [chemical binding]; other site 46234000367 Mg2+ binding site [ion binding]; other site 46234000368 G-X-G motif; other site 46234000369 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 46234000370 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 46234000371 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 46234000372 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 46234000373 elongation factor Tu; Region: tufA; CHL00071 46234000374 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 46234000375 G1 box; other site 46234000376 GEF interaction site [polypeptide binding]; other site 46234000377 GTP/Mg2+ binding site [chemical binding]; other site 46234000378 Switch I region; other site 46234000379 G2 box; other site 46234000380 G3 box; other site 46234000381 Switch II region; other site 46234000382 G4 box; other site 46234000383 G5 box; other site 46234000384 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 46234000385 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 46234000386 Antibiotic Binding Site [chemical binding]; other site 46234000387 elongation factor G; Reviewed; Region: PRK00007 46234000388 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 46234000389 G1 box; other site 46234000390 putative GEF interaction site [polypeptide binding]; other site 46234000391 GTP/Mg2+ binding site [chemical binding]; other site 46234000392 Switch I region; other site 46234000393 G2 box; other site 46234000394 G3 box; other site 46234000395 Switch II region; other site 46234000396 G4 box; other site 46234000397 G5 box; other site 46234000398 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 46234000399 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 46234000400 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 46234000401 30S ribosomal protein S7; Validated; Region: PRK05302 46234000402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 46234000403 S17 interaction site [polypeptide binding]; other site 46234000404 S8 interaction site; other site 46234000405 16S rRNA interaction site [nucleotide binding]; other site 46234000406 streptomycin interaction site [chemical binding]; other site 46234000407 23S rRNA interaction site [nucleotide binding]; other site 46234000408 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 46234000409 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 46234000410 Cupin domain; Region: Cupin_2; cl17218 46234000411 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 46234000412 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 46234000413 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 46234000414 active site 46234000415 dimer interface [polypeptide binding]; other site 46234000416 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 46234000417 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 46234000418 active site 46234000419 FMN binding site [chemical binding]; other site 46234000420 substrate binding site [chemical binding]; other site 46234000421 3Fe-4S cluster binding site [ion binding]; other site 46234000422 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 46234000423 domain interface; other site 46234000424 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 46234000425 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 46234000426 NodB motif; other site 46234000427 active site 46234000428 catalytic site [active] 46234000429 metal binding site [ion binding]; metal-binding site 46234000430 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 46234000431 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 46234000432 Ligand binding site; other site 46234000433 Putative Catalytic site; other site 46234000434 DXD motif; other site 46234000435 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 46234000436 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 46234000437 Predicted membrane protein [Function unknown]; Region: COG3463 46234000438 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 46234000439 Predicted integral membrane protein [Function unknown]; Region: COG5542 46234000440 Predicted integral membrane protein [Function unknown]; Region: COG5542 46234000441 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 46234000442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234000443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 46234000444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234000445 NAD(P) binding site [chemical binding]; other site 46234000446 active site 46234000447 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 46234000448 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 46234000449 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 46234000450 inhibitor-cofactor binding pocket; inhibition site 46234000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234000452 catalytic residue [active] 46234000453 Uncharacterized conserved protein [Function unknown]; Region: COG0432 46234000454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234000455 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 46234000456 NAD binding site [chemical binding]; other site 46234000457 substrate binding site [chemical binding]; other site 46234000458 homodimer interface [polypeptide binding]; other site 46234000459 active site 46234000460 Protein of unknown function (DUF563); Region: DUF563; pfam04577 46234000461 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 46234000462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234000463 active site 46234000464 motif I; other site 46234000465 motif II; other site 46234000466 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 46234000467 TPP-binding site [chemical binding]; other site 46234000468 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 46234000469 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 46234000470 PYR/PP interface [polypeptide binding]; other site 46234000471 dimer interface [polypeptide binding]; other site 46234000472 TPP binding site [chemical binding]; other site 46234000473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 46234000474 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 46234000475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234000476 active site 46234000477 motif I; other site 46234000478 motif II; other site 46234000479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234000480 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 46234000481 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 46234000482 active site 46234000483 homodimer interface [polypeptide binding]; other site 46234000484 catalytic site [active] 46234000485 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 46234000486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234000487 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 46234000488 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 46234000489 dimer interface [polypeptide binding]; other site 46234000490 active site 46234000491 N-terminal domain of RfaE; Region: RfaE_N; cd02172 46234000492 putative active site [active] 46234000493 (T/H)XGH motif; other site 46234000494 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 46234000495 substrate binding site [chemical binding]; other site 46234000496 ATP binding site [chemical binding]; other site 46234000497 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234000498 extended (e) SDRs; Region: SDR_e; cd08946 46234000499 NAD(P) binding site [chemical binding]; other site 46234000500 active site 46234000501 substrate binding site [chemical binding]; other site 46234000502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234000503 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 46234000504 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 46234000505 active site 46234000506 substrate binding site [chemical binding]; other site 46234000507 ATP binding site [chemical binding]; other site 46234000508 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 46234000509 nudix motif; other site 46234000510 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 46234000511 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 46234000512 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 46234000513 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 46234000514 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 46234000515 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 46234000516 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 46234000517 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 46234000518 lipoprotein signal peptidase; Provisional; Region: PRK14787 46234000519 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234000520 phosphopeptide binding site; other site 46234000521 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 46234000522 Transglycosylase; Region: Transgly; pfam00912 46234000523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 46234000524 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 46234000525 RRXRR protein; Region: RRXRR; pfam14239 46234000526 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234000527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234000528 active site 46234000529 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 46234000530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234000531 active site 46234000532 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 46234000533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234000534 dimer interface [polypeptide binding]; other site 46234000535 conserved gate region; other site 46234000536 putative PBP binding loops; other site 46234000537 ABC-ATPase subunit interface; other site 46234000538 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 46234000539 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 46234000540 active site 46234000541 catalytic residues [active] 46234000542 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 46234000543 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 46234000544 substrate binding site [chemical binding]; other site 46234000545 hexamer interface [polypeptide binding]; other site 46234000546 metal binding site [ion binding]; metal-binding site 46234000547 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 46234000548 exoribonuclease R; Provisional; Region: PRK11642 46234000549 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 46234000550 Zn binding site [ion binding]; other site 46234000551 toxin interface [polypeptide binding]; other site 46234000552 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 46234000553 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 46234000554 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 46234000555 hinge; other site 46234000556 active site 46234000557 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 46234000558 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234000559 putative catalytic residue [active] 46234000560 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 46234000561 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 46234000562 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 46234000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234000564 dimer interface [polypeptide binding]; other site 46234000565 conserved gate region; other site 46234000566 putative PBP binding loops; other site 46234000567 ABC-ATPase subunit interface; other site 46234000568 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 46234000569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 46234000570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234000571 dimer interface [polypeptide binding]; other site 46234000572 conserved gate region; other site 46234000573 putative PBP binding loops; other site 46234000574 ABC-ATPase subunit interface; other site 46234000575 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 46234000576 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 46234000577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234000578 catalytic residue [active] 46234000579 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 46234000580 Uncharacterized conserved protein [Function unknown]; Region: COG0432 46234000581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234000582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000583 active site 46234000584 phosphorylation site [posttranslational modification] 46234000585 intermolecular recognition site; other site 46234000586 dimerization interface [polypeptide binding]; other site 46234000587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234000588 DNA binding site [nucleotide binding] 46234000589 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 46234000590 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 46234000591 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 46234000592 ResB-like family; Region: ResB; pfam05140 46234000593 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 46234000594 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 46234000595 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 46234000596 nudix motif; other site 46234000597 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 46234000598 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 46234000599 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 46234000600 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 46234000601 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 46234000602 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 46234000603 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 46234000604 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 46234000605 active site 46234000606 dimer interface [polypeptide binding]; other site 46234000607 motif 1; other site 46234000608 motif 2; other site 46234000609 motif 3; other site 46234000610 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 46234000611 anticodon binding site; other site 46234000612 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 46234000613 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 46234000614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234000615 non-specific DNA binding site [nucleotide binding]; other site 46234000616 salt bridge; other site 46234000617 sequence-specific DNA binding site [nucleotide binding]; other site 46234000618 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 46234000619 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 46234000620 catalytic site [active] 46234000621 putative active site [active] 46234000622 putative substrate binding site [chemical binding]; other site 46234000623 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 46234000624 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 46234000625 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 46234000626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234000627 catalytic residue [active] 46234000628 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 46234000629 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 46234000630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234000631 Walker A motif; other site 46234000632 ATP binding site [chemical binding]; other site 46234000633 Walker B motif; other site 46234000634 arginine finger; other site 46234000635 GxxExxY protein; Region: GxxExxY; TIGR04256 46234000636 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 46234000637 putative rRNA binding site [nucleotide binding]; other site 46234000638 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 46234000639 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 46234000640 putative homodimer interface [polypeptide binding]; other site 46234000641 putative active site pocket [active] 46234000642 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 46234000643 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234000644 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 46234000645 OstA-like protein; Region: OstA; cl00844 46234000646 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 46234000647 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 46234000648 NADPH bind site [chemical binding]; other site 46234000649 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 46234000650 putative FMN binding site [chemical binding]; other site 46234000651 NADPH bind site [chemical binding]; other site 46234000652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234000653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234000654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234000655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234000656 active site 46234000657 substrate binding site [chemical binding]; other site 46234000658 ATP binding site [chemical binding]; other site 46234000659 activation loop (A-loop); other site 46234000660 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 46234000661 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 46234000662 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 46234000663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234000664 Walker A/P-loop; other site 46234000665 ATP binding site [chemical binding]; other site 46234000666 Q-loop/lid; other site 46234000667 ABC transporter signature motif; other site 46234000668 Walker B; other site 46234000669 D-loop; other site 46234000670 H-loop/switch region; other site 46234000671 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234000672 structural tetrad; other site 46234000673 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234000674 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234000675 structural tetrad; other site 46234000676 WD40 repeats; Region: WD40; smart00320 46234000677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 46234000678 metal binding site [ion binding]; metal-binding site 46234000679 active site 46234000680 I-site; other site 46234000681 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 46234000682 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 46234000683 Substrate binding site; other site 46234000684 Cupin domain; Region: Cupin_2; cl17218 46234000685 Transcriptional regulator [Transcription]; Region: LytR; COG1316 46234000686 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 46234000687 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000688 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234000689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000690 integral membrane protein MviN; Region: mviN; TIGR01695 46234000691 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 46234000692 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 46234000693 MgtE intracellular N domain; Region: MgtE_N; smart00924 46234000694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 46234000695 Divalent cation transporter; Region: MgtE; cl00786 46234000696 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 46234000697 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 46234000698 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 46234000699 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234000700 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000701 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234000702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000703 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000704 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234000705 Uncharacterized conserved protein [Function unknown]; Region: COG0062 46234000706 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 46234000707 putative substrate binding site [chemical binding]; other site 46234000708 putative ATP binding site [chemical binding]; other site 46234000709 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 46234000710 peripheral dimer interface [polypeptide binding]; other site 46234000711 core dimer interface [polypeptide binding]; other site 46234000712 L10 interface [polypeptide binding]; other site 46234000713 L11 interface [polypeptide binding]; other site 46234000714 putative EF-Tu interaction site [polypeptide binding]; other site 46234000715 putative EF-G interaction site [polypeptide binding]; other site 46234000716 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 46234000717 23S rRNA interface [nucleotide binding]; other site 46234000718 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 46234000719 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 46234000720 mRNA/rRNA interface [nucleotide binding]; other site 46234000721 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 46234000722 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 46234000723 23S rRNA interface [nucleotide binding]; other site 46234000724 L7/L12 interface [polypeptide binding]; other site 46234000725 putative thiostrepton binding site; other site 46234000726 L25 interface [polypeptide binding]; other site 46234000727 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 46234000728 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 46234000729 putative homodimer interface [polypeptide binding]; other site 46234000730 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 46234000731 heterodimer interface [polypeptide binding]; other site 46234000732 homodimer interface [polypeptide binding]; other site 46234000733 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 46234000734 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 46234000735 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 46234000736 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 46234000737 HflX GTPase family; Region: HflX; cd01878 46234000738 G1 box; other site 46234000739 GTP/Mg2+ binding site [chemical binding]; other site 46234000740 Switch I region; other site 46234000741 G2 box; other site 46234000742 G3 box; other site 46234000743 Switch II region; other site 46234000744 G4 box; other site 46234000745 G5 box; other site 46234000746 PemK-like protein; Region: PemK; pfam02452 46234000747 Translationally controlled tumour protein; Region: TCTP; cl08291 46234000748 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234000749 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 46234000750 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 46234000751 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 46234000752 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 46234000753 GxxExxY protein; Region: GxxExxY; TIGR04256 46234000754 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 46234000755 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 46234000756 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 46234000757 putative active site [active] 46234000758 catalytic residue [active] 46234000759 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 46234000760 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 46234000761 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 46234000762 active site 46234000763 metal binding site [ion binding]; metal-binding site 46234000764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 46234000765 FIST N domain; Region: FIST; pfam08495 46234000766 FIST C domain; Region: FIST_C; pfam10442 46234000767 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 46234000768 DNA methylase; Region: N6_N4_Mtase; pfam01555 46234000769 DNA methylase; Region: N6_N4_Mtase; pfam01555 46234000770 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 46234000771 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 46234000772 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 46234000773 adaptive-response sensory kinase; Validated; Region: PRK09303 46234000774 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 46234000775 tetramer interface [polypeptide binding]; other site 46234000776 dimer interface [polypeptide binding]; other site 46234000777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234000778 dimer interface [polypeptide binding]; other site 46234000779 phosphorylation site [posttranslational modification] 46234000780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234000781 ATP binding site [chemical binding]; other site 46234000782 Mg2+ binding site [ion binding]; other site 46234000783 G-X-G motif; other site 46234000784 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 46234000785 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 46234000786 Putative addiction module component; Region: Unstab_antitox; cl09921 46234000787 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 46234000788 GUN4-like; Region: GUN4; pfam05419 46234000789 S-layer homology domain; Region: SLH; pfam00395 46234000790 S-layer homology domain; Region: SLH; pfam00395 46234000791 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 46234000792 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234000793 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234000794 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 46234000795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234000796 FeS/SAM binding site; other site 46234000797 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 46234000798 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 46234000799 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 46234000800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234000801 RNA binding surface [nucleotide binding]; other site 46234000802 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 46234000803 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 46234000804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234000805 putative substrate translocation pore; other site 46234000806 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 46234000807 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 46234000808 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 46234000809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234000810 S-adenosylmethionine binding site [chemical binding]; other site 46234000811 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 46234000812 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234000813 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234000814 active site 46234000815 substrate binding site [chemical binding]; other site 46234000816 ATP binding site [chemical binding]; other site 46234000817 activation loop (A-loop); other site 46234000818 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 46234000819 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234000820 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 46234000821 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234000822 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234000823 TPR repeat; Region: TPR_11; pfam13414 46234000824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000825 binding surface 46234000826 TPR motif; other site 46234000827 TPR repeat; Region: TPR_11; pfam13414 46234000828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234000829 TPR repeat; Region: TPR_11; pfam13414 46234000830 binding surface 46234000831 TPR motif; other site 46234000832 XisI protein; Region: XisI; pfam08869 46234000833 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234000834 YcfA-like protein; Region: YcfA; pfam07927 46234000835 Uncharacterized conserved protein [Function unknown]; Region: COG2361 46234000836 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 46234000837 active site 46234000838 NTP binding site [chemical binding]; other site 46234000839 metal binding triad [ion binding]; metal-binding site 46234000840 antibiotic binding site [chemical binding]; other site 46234000841 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 46234000842 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 46234000843 active site 46234000844 catalytic site [active] 46234000845 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 46234000846 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 46234000847 putative catalytic site [active] 46234000848 putative phosphate binding site [ion binding]; other site 46234000849 active site 46234000850 metal binding site A [ion binding]; metal-binding site 46234000851 DNA binding site [nucleotide binding] 46234000852 putative AP binding site [nucleotide binding]; other site 46234000853 putative metal binding site B [ion binding]; other site 46234000854 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 46234000855 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 46234000856 NAD(P) binding site [chemical binding]; other site 46234000857 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234000858 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234000859 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 46234000860 active site 46234000861 multifunctional aminopeptidase A; Provisional; Region: PRK00913 46234000862 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 46234000863 interface (dimer of trimers) [polypeptide binding]; other site 46234000864 Substrate-binding/catalytic site; other site 46234000865 Zn-binding sites [ion binding]; other site 46234000866 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 46234000867 putative efflux protein, MATE family; Region: matE; TIGR00797 46234000868 putative phosphate acyltransferase; Provisional; Region: PRK05331 46234000869 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 46234000870 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 46234000871 dimer interface [polypeptide binding]; other site 46234000872 active site 46234000873 CoA binding pocket [chemical binding]; other site 46234000874 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 46234000875 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234000876 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 46234000877 Fatty acid desaturase; Region: FA_desaturase; pfam00487 46234000878 Di-iron ligands [ion binding]; other site 46234000879 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 46234000880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 46234000881 dimerization interface [polypeptide binding]; other site 46234000882 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 46234000883 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 46234000884 putative acyl-acceptor binding pocket; other site 46234000885 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234000886 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 46234000887 cofactor binding site; other site 46234000888 DNA binding site [nucleotide binding] 46234000889 substrate interaction site [chemical binding]; other site 46234000890 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 46234000891 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 46234000892 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 46234000893 trmE is a tRNA modification GTPase; Region: trmE; cd04164 46234000894 G1 box; other site 46234000895 GTP/Mg2+ binding site [chemical binding]; other site 46234000896 Switch I region; other site 46234000897 G2 box; other site 46234000898 Switch II region; other site 46234000899 G3 box; other site 46234000900 G4 box; other site 46234000901 G5 box; other site 46234000902 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 46234000903 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 46234000904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234000905 ATP binding site [chemical binding]; other site 46234000906 Mg2+ binding site [ion binding]; other site 46234000907 G-X-G motif; other site 46234000908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000909 active site 46234000910 phosphorylation site [posttranslational modification] 46234000911 intermolecular recognition site; other site 46234000912 dimerization interface [polypeptide binding]; other site 46234000913 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234000914 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234000915 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 46234000916 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 46234000917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234000918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234000919 active site 46234000920 phosphorylation site [posttranslational modification] 46234000921 intermolecular recognition site; other site 46234000922 dimerization interface [polypeptide binding]; other site 46234000923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234000924 DNA binding residues [nucleotide binding] 46234000925 dimerization interface [polypeptide binding]; other site 46234000926 Predicted permeases [General function prediction only]; Region: COG0795 46234000927 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 46234000928 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 46234000929 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 46234000930 Walker A/P-loop; other site 46234000931 ATP binding site [chemical binding]; other site 46234000932 Q-loop/lid; other site 46234000933 ABC transporter signature motif; other site 46234000934 Walker B; other site 46234000935 D-loop; other site 46234000936 H-loop/switch region; other site 46234000937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 46234000938 OstA-like protein; Region: OstA; pfam03968 46234000939 Domain of unknown function (DUF309); Region: DUF309; pfam03745 46234000940 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 46234000941 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 46234000942 Protein of unknown function DUF58; Region: DUF58; pfam01882 46234000943 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 46234000944 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 46234000945 Winged helix-turn helix; Region: HTH_29; pfam13551 46234000946 Homeodomain-like domain; Region: HTH_23; pfam13384 46234000947 Winged helix-turn helix; Region: HTH_33; pfam13592 46234000948 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 46234000949 ligand binding site [chemical binding]; other site 46234000950 flexible hinge region; other site 46234000951 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234000952 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 46234000953 putative active site [active] 46234000954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234000955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234000956 Walker A/P-loop; other site 46234000957 ATP binding site [chemical binding]; other site 46234000958 Q-loop/lid; other site 46234000959 ABC transporter signature motif; other site 46234000960 Walker B; other site 46234000961 D-loop; other site 46234000962 H-loop/switch region; other site 46234000963 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234000964 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 46234000965 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234000966 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 46234000967 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 46234000968 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234000969 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 46234000970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234000971 FeS/SAM binding site; other site 46234000972 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 46234000973 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 46234000974 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234000975 ATP-grasp domain; Region: ATP-grasp_4; cl17255 46234000976 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 46234000977 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 46234000978 active site 46234000979 Zn binding site [ion binding]; other site 46234000980 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 46234000981 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 46234000982 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 46234000983 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 46234000984 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 46234000985 Bacterial sugar transferase; Region: Bac_transf; pfam02397 46234000986 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 46234000987 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 46234000988 NAD binding site [chemical binding]; other site 46234000989 homodimer interface [polypeptide binding]; other site 46234000990 active site 46234000991 substrate binding site [chemical binding]; other site 46234000992 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 46234000993 Chain length determinant protein; Region: Wzz; pfam02706 46234000994 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 46234000995 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 46234000996 ParA/MinD ATPase like; Region: ParA; pfam10609 46234000997 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234000998 putative active site [active] 46234000999 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 46234001000 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 46234001001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234001002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234001003 S-adenosylmethionine binding site [chemical binding]; other site 46234001004 putative glycosyl transferase; Provisional; Region: PRK10063 46234001005 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 46234001006 metal-binding site 46234001007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 46234001008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234001009 active site 46234001010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234001011 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234001012 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234001013 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 46234001014 Predicted ATPase [General function prediction only]; Region: COG4637 46234001015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234001016 Walker A/P-loop; other site 46234001017 ATP binding site [chemical binding]; other site 46234001018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234001019 Q-loop/lid; other site 46234001020 ABC transporter signature motif; other site 46234001021 Walker B; other site 46234001022 D-loop; other site 46234001023 H-loop/switch region; other site 46234001024 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 46234001025 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 46234001026 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 46234001027 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 46234001028 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 46234001029 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 46234001030 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 46234001031 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 46234001032 dimer interface [polypeptide binding]; other site 46234001033 active site 46234001034 glycine-pyridoxal phosphate binding site [chemical binding]; other site 46234001035 folate binding site [chemical binding]; other site 46234001036 Mg chelatase-related protein; Region: TIGR00368 46234001037 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 46234001038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234001039 Walker A motif; other site 46234001040 ATP binding site [chemical binding]; other site 46234001041 Walker B motif; other site 46234001042 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 46234001043 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001044 putative active site [active] 46234001045 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001046 putative active site [active] 46234001047 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234001048 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 46234001049 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 46234001050 nucleotide binding site/active site [active] 46234001051 HIT family signature motif; other site 46234001052 catalytic residue [active] 46234001053 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 46234001054 protein I interface; other site 46234001055 D2 interface; other site 46234001056 protein T interface; other site 46234001057 chlorophyll binding site; other site 46234001058 beta carotene binding site; other site 46234001059 pheophytin binding site; other site 46234001060 manganese-stabilizing polypeptide interface; other site 46234001061 CP43 interface; other site 46234001062 protein L interface; other site 46234001063 oxygen evolving complex binding site; other site 46234001064 bromide binding site; other site 46234001065 quinone binding site; other site 46234001066 Fe binding site [ion binding]; other site 46234001067 core light harvesting interface; other site 46234001068 cytochrome b559 alpha subunit interface; other site 46234001069 cytochrome c-550 interface; other site 46234001070 protein J interface; other site 46234001071 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 46234001072 putative hydrophobic ligand binding site [chemical binding]; other site 46234001073 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 46234001074 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 46234001075 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 46234001076 catalytic site [active] 46234001077 putative active site [active] 46234001078 putative substrate binding site [chemical binding]; other site 46234001079 TPR repeat; Region: TPR_11; pfam13414 46234001080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234001081 binding surface 46234001082 TPR motif; other site 46234001083 TPR repeat; Region: TPR_11; pfam13414 46234001084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234001085 binding surface 46234001086 TPR motif; other site 46234001087 TPR repeat; Region: TPR_11; pfam13414 46234001088 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234001089 Tetratricopeptide repeat; Region: TPR_1; pfam00515 46234001090 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234001091 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 46234001092 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 46234001093 plastocyanin; Provisional; Region: PRK02710 46234001094 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234001095 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234001096 catalytic residues [active] 46234001097 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 46234001098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234001099 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 46234001100 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 46234001101 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 46234001102 intersubunit interface [polypeptide binding]; other site 46234001103 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 46234001104 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 46234001105 active site 46234001106 substrate binding site [chemical binding]; other site 46234001107 metal binding site [ion binding]; metal-binding site 46234001108 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 46234001109 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 46234001110 active site 46234001111 substrate binding site [chemical binding]; other site 46234001112 cosubstrate binding site; other site 46234001113 catalytic site [active] 46234001114 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 46234001115 hypothetical protein; Validated; Region: PRK07413 46234001116 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 46234001117 Walker A motif; other site 46234001118 homodimer interface [polypeptide binding]; other site 46234001119 ATP binding site [chemical binding]; other site 46234001120 hydroxycobalamin binding site [chemical binding]; other site 46234001121 Walker B motif; other site 46234001122 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 46234001123 Walker A motif; other site 46234001124 homodimer interface [polypeptide binding]; other site 46234001125 ATP binding site [chemical binding]; other site 46234001126 hydroxycobalamin binding site [chemical binding]; other site 46234001127 Walker B motif; other site 46234001128 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234001129 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234001130 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001131 putative active site [active] 46234001132 Cobalt transport protein; Region: CbiQ; pfam02361 46234001133 GTP-binding protein Der; Reviewed; Region: PRK00093 46234001134 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 46234001135 G1 box; other site 46234001136 GTP/Mg2+ binding site [chemical binding]; other site 46234001137 Switch I region; other site 46234001138 G2 box; other site 46234001139 Switch II region; other site 46234001140 G3 box; other site 46234001141 G4 box; other site 46234001142 G5 box; other site 46234001143 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 46234001144 G1 box; other site 46234001145 GTP/Mg2+ binding site [chemical binding]; other site 46234001146 Switch I region; other site 46234001147 G2 box; other site 46234001148 G3 box; other site 46234001149 Switch II region; other site 46234001150 G4 box; other site 46234001151 G5 box; other site 46234001152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234001154 active site 46234001155 phosphorylation site [posttranslational modification] 46234001156 intermolecular recognition site; other site 46234001157 dimerization interface [polypeptide binding]; other site 46234001158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234001159 DNA binding site [nucleotide binding] 46234001160 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 46234001161 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 46234001162 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 46234001163 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 46234001164 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 46234001165 active site 46234001166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 46234001167 metal binding site 2 [ion binding]; metal-binding site 46234001168 putative DNA binding helix; other site 46234001169 metal binding site 1 [ion binding]; metal-binding site 46234001170 dimer interface [polypeptide binding]; other site 46234001171 structural Zn2+ binding site [ion binding]; other site 46234001172 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 46234001173 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 46234001174 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 46234001175 putative active site [active] 46234001176 catalytic triad [active] 46234001177 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 46234001178 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 46234001179 KWG Leptospira; Region: KWG; pfam07656 46234001180 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234001181 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 46234001182 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 46234001183 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 46234001184 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 46234001185 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 46234001186 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 46234001187 putative active site [active] 46234001188 homotetrameric interface [polypeptide binding]; other site 46234001189 metal binding site [ion binding]; metal-binding site 46234001190 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234001191 HicB family; Region: HicB; pfam05534 46234001192 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 46234001193 Ligand Binding Site [chemical binding]; other site 46234001194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 46234001195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 46234001196 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 46234001197 Mg binding site [ion binding]; other site 46234001198 nucleotide binding site [chemical binding]; other site 46234001199 putative protofilament interface [polypeptide binding]; other site 46234001200 folate/biopterin transporter; Region: fbt; TIGR00788 46234001201 BT1 family; Region: BT1; pfam03092 46234001202 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 46234001203 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 46234001204 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 46234001205 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 46234001206 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 46234001207 NAD(P) binding site [chemical binding]; other site 46234001208 Predicted ATPase [General function prediction only]; Region: COG4637 46234001209 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 46234001210 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 46234001211 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 46234001212 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 46234001213 putative active site [active] 46234001214 substrate binding site [chemical binding]; other site 46234001215 putative cosubstrate binding site; other site 46234001216 catalytic site [active] 46234001217 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 46234001218 substrate binding site [chemical binding]; other site 46234001219 ABC-2 type transporter; Region: ABC2_membrane; cl17235 46234001220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 46234001221 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 46234001222 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234001223 catalytic triad [active] 46234001224 cobyric acid synthase; Provisional; Region: PRK00784 46234001225 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 46234001226 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 46234001227 catalytic triad [active] 46234001228 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234001229 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234001230 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234001231 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234001232 LVIVD repeat; Region: LVIVD; pfam08309 46234001233 LVIVD repeat; Region: LVIVD; pfam08309 46234001234 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234001235 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234001236 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234001237 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234001238 cell division protein; Validated; Region: ftsH; CHL00176 46234001239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234001240 Walker A motif; other site 46234001241 ATP binding site [chemical binding]; other site 46234001242 Walker B motif; other site 46234001243 arginine finger; other site 46234001244 Peptidase family M41; Region: Peptidase_M41; pfam01434 46234001245 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234001246 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001247 putative active site [active] 46234001248 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 46234001249 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 46234001250 HIGH motif; other site 46234001251 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 46234001252 active site 46234001253 KMSKS motif; other site 46234001254 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 46234001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 46234001256 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 46234001257 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 46234001258 RNase_H superfamily; Region: RNase_H_2; pfam13482 46234001259 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 46234001260 diiron binding motif [ion binding]; other site 46234001261 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 46234001262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 46234001263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234001264 dimer interface [polypeptide binding]; other site 46234001265 conserved gate region; other site 46234001266 putative PBP binding loops; other site 46234001267 ABC-ATPase subunit interface; other site 46234001268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 46234001269 conserved hypothetical protein; Region: TIGR03492 46234001270 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234001271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234001272 active site 46234001273 phosphorylation site [posttranslational modification] 46234001274 intermolecular recognition site; other site 46234001275 dimerization interface [polypeptide binding]; other site 46234001276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234001277 DNA binding residues [nucleotide binding] 46234001278 dimerization interface [polypeptide binding]; other site 46234001279 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234001280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234001281 active site 46234001282 phosphorylation site [posttranslational modification] 46234001283 intermolecular recognition site; other site 46234001284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234001285 dimerization interface [polypeptide binding]; other site 46234001286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234001287 dimer interface [polypeptide binding]; other site 46234001288 phosphorylation site [posttranslational modification] 46234001289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234001290 ATP binding site [chemical binding]; other site 46234001291 Mg2+ binding site [ion binding]; other site 46234001292 G-X-G motif; other site 46234001293 Response regulator receiver domain; Region: Response_reg; pfam00072 46234001294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234001295 active site 46234001296 phosphorylation site [posttranslational modification] 46234001297 intermolecular recognition site; other site 46234001298 dimerization interface [polypeptide binding]; other site 46234001299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234001300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234001301 dimer interface [polypeptide binding]; other site 46234001302 phosphorylation site [posttranslational modification] 46234001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 46234001304 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 46234001305 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001306 putative active site [active] 46234001307 MoxR-like ATPases [General function prediction only]; Region: COG0714 46234001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234001309 Walker A motif; other site 46234001310 ATP binding site [chemical binding]; other site 46234001311 Walker B motif; other site 46234001312 arginine finger; other site 46234001313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 46234001314 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234001315 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234001316 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 46234001317 Subunit I/III interface [polypeptide binding]; other site 46234001318 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 46234001319 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 46234001320 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 46234001321 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 46234001322 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 46234001323 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 46234001324 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 46234001325 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 46234001326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234001327 non-specific DNA binding site [nucleotide binding]; other site 46234001328 salt bridge; other site 46234001329 sequence-specific DNA binding site [nucleotide binding]; other site 46234001330 gamma-glutamyl kinase; Provisional; Region: PRK05429 46234001331 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 46234001332 nucleotide binding site [chemical binding]; other site 46234001333 homotetrameric interface [polypeptide binding]; other site 46234001334 putative phosphate binding site [ion binding]; other site 46234001335 putative allosteric binding site; other site 46234001336 PUA domain; Region: PUA; pfam01472 46234001337 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 46234001338 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 46234001339 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 46234001340 Walker A/P-loop; other site 46234001341 ATP binding site [chemical binding]; other site 46234001342 Q-loop/lid; other site 46234001343 ABC transporter signature motif; other site 46234001344 Walker B; other site 46234001345 D-loop; other site 46234001346 H-loop/switch region; other site 46234001347 TOBE domain; Region: TOBE; pfam03459 46234001348 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 46234001349 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 46234001350 putative NAD(P) binding site [chemical binding]; other site 46234001351 active site 46234001352 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 46234001353 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 46234001354 XisH protein; Region: XisH; pfam08814 46234001355 XisI protein; Region: XisI; pfam08869 46234001356 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234001357 YcfA-like protein; Region: YcfA; pfam07927 46234001358 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 46234001359 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 46234001360 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 46234001361 generic binding surface I; other site 46234001362 generic binding surface II; other site 46234001363 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234001364 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 46234001365 carboxyltransferase (CT) interaction site; other site 46234001366 biotinylation site [posttranslational modification]; other site 46234001367 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234001368 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 46234001369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 46234001370 ligand binding site [chemical binding]; other site 46234001371 flexible hinge region; other site 46234001372 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234001373 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 46234001374 putative active site [active] 46234001375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234001376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234001377 Walker A/P-loop; other site 46234001378 ATP binding site [chemical binding]; other site 46234001379 Q-loop/lid; other site 46234001380 ABC transporter signature motif; other site 46234001381 Walker B; other site 46234001382 D-loop; other site 46234001383 H-loop/switch region; other site 46234001384 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 46234001385 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 46234001386 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234001387 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 46234001388 catalytic triad [active] 46234001389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234001390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234001391 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 46234001392 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 46234001393 active site 46234001394 interdomain interaction site; other site 46234001395 putative metal-binding site [ion binding]; other site 46234001396 nucleotide binding site [chemical binding]; other site 46234001397 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 46234001398 domain I; other site 46234001399 DNA binding groove [nucleotide binding] 46234001400 phosphate binding site [ion binding]; other site 46234001401 domain II; other site 46234001402 domain III; other site 46234001403 nucleotide binding site [chemical binding]; other site 46234001404 catalytic site [active] 46234001405 domain IV; other site 46234001406 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234001407 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234001408 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234001409 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234001410 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001411 putative active site [active] 46234001412 Uncharacterized conserved protein [Function unknown]; Region: COG1565 46234001413 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 46234001414 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 46234001415 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 46234001416 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 46234001417 dimer interface [polypeptide binding]; other site 46234001418 ssDNA binding site [nucleotide binding]; other site 46234001419 tetramer (dimer of dimers) interface [polypeptide binding]; other site 46234001420 Family 4 glycosyl hydrolase C-terminal domain; Region: Glyco_hydro_4C; pfam11975 46234001421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234001422 non-specific DNA binding site [nucleotide binding]; other site 46234001423 salt bridge; other site 46234001424 sequence-specific DNA binding site [nucleotide binding]; other site 46234001425 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 46234001426 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 46234001427 Walker A/P-loop; other site 46234001428 ATP binding site [chemical binding]; other site 46234001429 Q-loop/lid; other site 46234001430 ABC transporter signature motif; other site 46234001431 Walker B; other site 46234001432 D-loop; other site 46234001433 H-loop/switch region; other site 46234001434 DevC protein; Region: devC; TIGR01185 46234001435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234001436 FtsX-like permease family; Region: FtsX; pfam02687 46234001437 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 46234001438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234001439 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234001440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 46234001441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 46234001442 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 46234001443 Domain of unknown function DUF148; Region: DUF148; pfam02520 46234001444 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 46234001445 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 46234001446 active site 46234001447 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234001448 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 46234001449 homodimer interface [polypeptide binding]; other site 46234001450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234001451 catalytic residue [active] 46234001452 AAA ATPase domain; Region: AAA_16; pfam13191 46234001453 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234001454 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234001455 active site 46234001456 metal binding site [ion binding]; metal-binding site 46234001457 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 46234001458 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 46234001459 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234001460 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234001461 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234001462 active site 46234001463 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234001464 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 46234001465 active site 46234001466 Predicted membrane protein [Function unknown]; Region: COG2324 46234001467 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 46234001468 ribosomal protein L21; Region: rpl21; CHL00075 46234001469 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 46234001470 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 46234001471 TPR repeat; Region: TPR_11; pfam13414 46234001472 TPR repeat; Region: TPR_11; pfam13414 46234001473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234001474 TPR motif; other site 46234001475 binding surface 46234001476 TPR repeat; Region: TPR_11; pfam13414 46234001477 TPR repeat; Region: TPR_11; pfam13414 46234001478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234001479 binding surface 46234001480 TPR motif; other site 46234001481 TPR repeat; Region: TPR_11; pfam13414 46234001482 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 46234001483 Putative zinc-finger; Region: zf-HC2; pfam13490 46234001484 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 46234001485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234001486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234001487 DNA binding residues [nucleotide binding] 46234001488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 46234001489 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 46234001490 Late competence development protein ComFB; Region: ComFB; pfam10719 46234001491 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 46234001492 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234001493 NAD synthetase; Provisional; Region: PRK13981 46234001494 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 46234001495 multimer interface [polypeptide binding]; other site 46234001496 active site 46234001497 catalytic triad [active] 46234001498 protein interface 1 [polypeptide binding]; other site 46234001499 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 46234001500 homodimer interface [polypeptide binding]; other site 46234001501 NAD binding pocket [chemical binding]; other site 46234001502 ATP binding pocket [chemical binding]; other site 46234001503 Mg binding site [ion binding]; other site 46234001504 active-site loop [active] 46234001505 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 46234001506 nudix motif; other site 46234001507 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 46234001508 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 46234001509 active site 46234001510 (T/H)XGH motif; other site 46234001511 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 46234001512 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 46234001513 Aspartase; Region: Aspartase; cd01357 46234001514 active sites [active] 46234001515 tetramer interface [polypeptide binding]; other site 46234001516 cell division protein; Validated; Region: ftsH; CHL00176 46234001517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234001518 Walker A motif; other site 46234001519 ATP binding site [chemical binding]; other site 46234001520 Walker B motif; other site 46234001521 arginine finger; other site 46234001522 Peptidase family M41; Region: Peptidase_M41; pfam01434 46234001523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234001524 Probable transposase; Region: OrfB_IS605; pfam01385 46234001525 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 46234001526 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 46234001527 Tetramer interface [polypeptide binding]; other site 46234001528 active site 46234001529 FMN-binding site [chemical binding]; other site 46234001530 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 46234001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234001532 S-adenosylmethionine binding site [chemical binding]; other site 46234001533 Tic22-like family; Region: Tic22; cl04468 46234001534 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 46234001535 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 46234001536 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 46234001537 putative switch regulator; other site 46234001538 non-specific DNA interactions [nucleotide binding]; other site 46234001539 DNA binding site [nucleotide binding] 46234001540 sequence specific DNA binding site [nucleotide binding]; other site 46234001541 putative cAMP binding site [chemical binding]; other site 46234001542 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 46234001543 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 46234001544 putative dimer interface [polypeptide binding]; other site 46234001545 active site pocket [active] 46234001546 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 46234001547 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 46234001548 Nucleoside recognition; Region: Gate; pfam07670 46234001549 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 46234001550 Phytochelatin synthase; Region: Phytochelatin; pfam05023 46234001551 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 46234001552 Domain of unknown function DUF20; Region: UPF0118; pfam01594 46234001553 Transcriptional regulator [Transcription]; Region: LytR; COG1316 46234001554 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 46234001555 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 46234001556 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 46234001557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234001558 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234001559 active site 46234001560 ATP binding site [chemical binding]; other site 46234001561 substrate binding site [chemical binding]; other site 46234001562 activation loop (A-loop); other site 46234001563 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 46234001564 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 46234001565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234001566 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 46234001567 putative active site [active] 46234001568 heme pocket [chemical binding]; other site 46234001569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234001570 dimer interface [polypeptide binding]; other site 46234001571 phosphorylation site [posttranslational modification] 46234001572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234001573 ATP binding site [chemical binding]; other site 46234001574 Mg2+ binding site [ion binding]; other site 46234001575 G-X-G motif; other site 46234001576 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 46234001577 Peptidase family M50; Region: Peptidase_M50; pfam02163 46234001578 active site 46234001579 putative substrate binding region [chemical binding]; other site 46234001580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 46234001581 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 46234001582 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 46234001583 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 46234001584 Flavoprotein; Region: Flavoprotein; pfam02441 46234001585 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 46234001586 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 46234001587 Predicted esterase [General function prediction only]; Region: COG0400 46234001588 putative hydrolase; Provisional; Region: PRK11460 46234001589 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 46234001590 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 46234001591 purine monophosphate binding site [chemical binding]; other site 46234001592 dimer interface [polypeptide binding]; other site 46234001593 putative catalytic residues [active] 46234001594 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 46234001595 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 46234001596 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 46234001597 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 46234001598 AAA ATPase domain; Region: AAA_16; pfam13191 46234001599 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 46234001600 catalytic site [active] 46234001601 putative active site [active] 46234001602 putative substrate binding site [chemical binding]; other site 46234001603 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 46234001604 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 46234001605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 46234001606 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 46234001607 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234001608 P-loop; other site 46234001609 Magnesium ion binding site [ion binding]; other site 46234001610 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234001611 Magnesium ion binding site [ion binding]; other site 46234001612 TIGR04255 family protein; Region: sporadTIGR04255 46234001613 Glutaminase; Region: Glutaminase; cl00907 46234001614 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 46234001615 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 46234001616 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 46234001617 Pantoate-beta-alanine ligase; Region: PanC; cd00560 46234001618 active site 46234001619 ATP-binding site [chemical binding]; other site 46234001620 pantoate-binding site; other site 46234001621 HXXH motif; other site 46234001622 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 46234001623 CMP-binding site; other site 46234001624 The sites determining sugar specificity; other site 46234001625 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 46234001626 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 46234001627 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 46234001628 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 46234001629 O-Antigen ligase; Region: Wzy_C; pfam04932 46234001630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 46234001631 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 46234001632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 46234001633 DnaJ domain; Region: DnaJ; pfam00226 46234001634 HSP70 interaction site [polypeptide binding]; other site 46234001635 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 46234001636 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 46234001637 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 46234001638 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 46234001639 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 46234001640 cytochrome b subunit interaction site [polypeptide binding]; other site 46234001641 [2Fe-2S] cluster binding site [ion binding]; other site 46234001642 apocytochrome f; Reviewed; Region: PRK02693 46234001643 cytochrome f; Region: petA; CHL00037 46234001644 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 46234001645 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 46234001646 active site 46234001647 trimer interface [polypeptide binding]; other site 46234001648 allosteric site; other site 46234001649 active site lid [active] 46234001650 hexamer (dimer of trimers) interface [polypeptide binding]; other site 46234001651 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 46234001652 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 46234001653 Walker A/P-loop; other site 46234001654 ATP binding site [chemical binding]; other site 46234001655 Q-loop/lid; other site 46234001656 ABC transporter signature motif; other site 46234001657 Walker B; other site 46234001658 D-loop; other site 46234001659 H-loop/switch region; other site 46234001660 DevC protein; Region: devC; TIGR01185 46234001661 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234001662 FtsX-like permease family; Region: FtsX; pfam02687 46234001663 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 46234001664 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234001665 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 46234001666 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234001667 active site 46234001668 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234001669 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 46234001670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234001671 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 46234001672 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 46234001673 putative NADP binding site [chemical binding]; other site 46234001674 active site 46234001675 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 46234001676 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 46234001677 active site 46234001678 Acyl transferase domain; Region: Acyl_transf_1; cl08282 46234001679 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 46234001680 FMN binding site [chemical binding]; other site 46234001681 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 46234001682 substrate binding site [chemical binding]; other site 46234001683 putative catalytic residue [active] 46234001684 acyltransferase PapA5; Provisional; Region: PRK09294 46234001685 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234001686 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 46234001687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 46234001688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 46234001689 catalytic residue [active] 46234001690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 46234001691 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 46234001692 pyrroline-5-carboxylate reductase; Region: PLN02688 46234001693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 46234001694 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234001695 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 46234001696 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 46234001697 G1 box; other site 46234001698 GTP/Mg2+ binding site [chemical binding]; other site 46234001699 G2 box; other site 46234001700 Switch I region; other site 46234001701 G3 box; other site 46234001702 Switch II region; other site 46234001703 G4 box; other site 46234001704 YcfA-like protein; Region: YcfA; pfam07927 46234001705 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234001706 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234001707 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234001708 DEAD-like helicases superfamily; Region: DEXDc; smart00487 46234001709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234001710 ATP binding site [chemical binding]; other site 46234001711 putative Mg++ binding site [ion binding]; other site 46234001712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234001713 nucleotide binding region [chemical binding]; other site 46234001714 ATP-binding site [chemical binding]; other site 46234001715 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 46234001716 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234001717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234001718 binding surface 46234001719 TPR motif; other site 46234001720 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234001721 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 46234001722 phosphate binding site [ion binding]; other site 46234001723 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 46234001724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234001725 ATP binding site [chemical binding]; other site 46234001726 putative Mg++ binding site [ion binding]; other site 46234001727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234001728 nucleotide binding region [chemical binding]; other site 46234001729 ATP-binding site [chemical binding]; other site 46234001730 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 46234001731 Protein of unknown function (DUF790); Region: DUF790; pfam05626 46234001732 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 46234001733 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234001734 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 46234001735 putative active site [active] 46234001736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234001737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234001738 Walker A/P-loop; other site 46234001739 ATP binding site [chemical binding]; other site 46234001740 Q-loop/lid; other site 46234001741 ABC transporter signature motif; other site 46234001742 Walker B; other site 46234001743 D-loop; other site 46234001744 H-loop/switch region; other site 46234001745 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234001746 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234001747 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 46234001748 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 46234001749 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 46234001750 Zn binding site [ion binding]; other site 46234001751 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 46234001752 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 46234001753 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 46234001754 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 46234001755 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 46234001756 Walker A/P-loop; other site 46234001757 ATP binding site [chemical binding]; other site 46234001758 Q-loop/lid; other site 46234001759 ABC transporter signature motif; other site 46234001760 Walker B; other site 46234001761 D-loop; other site 46234001762 H-loop/switch region; other site 46234001763 Basal layer antifungal peptide (BAP); Region: BAP; pfam06639 46234001764 TOBE domain; Region: TOBE_2; pfam08402 46234001765 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 46234001766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 46234001767 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 46234001768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234001769 dimer interface [polypeptide binding]; other site 46234001770 conserved gate region; other site 46234001771 putative PBP binding loops; other site 46234001772 ABC-ATPase subunit interface; other site 46234001773 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 46234001774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 46234001775 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 46234001776 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234001777 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234001778 structural tetrad; other site 46234001779 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 46234001780 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 46234001781 Walker A/P-loop; other site 46234001782 ATP binding site [chemical binding]; other site 46234001783 Q-loop/lid; other site 46234001784 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 46234001785 ABC transporter signature motif; other site 46234001786 Walker B; other site 46234001787 D-loop; other site 46234001788 H-loop/switch region; other site 46234001789 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 46234001790 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 46234001791 hinge; other site 46234001792 active site 46234001793 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 46234001794 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 46234001795 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 46234001796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 46234001797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 46234001798 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 46234001799 putative dimerization interface [polypeptide binding]; other site 46234001800 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 46234001801 Protein of unknown function (DUF497); Region: DUF497; pfam04365 46234001802 YcfA-like protein; Region: YcfA; pfam07927 46234001803 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234001804 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 46234001805 putative active site [active] 46234001806 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 46234001807 magnesium chelatase subunit H; Provisional; Region: PRK12493 46234001808 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 46234001809 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 46234001810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234001811 non-specific DNA binding site [nucleotide binding]; other site 46234001812 salt bridge; other site 46234001813 sequence-specific DNA binding site [nucleotide binding]; other site 46234001814 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 46234001815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234001816 S-adenosylmethionine binding site [chemical binding]; other site 46234001817 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 46234001818 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001819 putative active site [active] 46234001820 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 46234001821 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 46234001822 putative active site [active] 46234001823 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 46234001824 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 46234001825 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 46234001826 dimer interface [polypeptide binding]; other site 46234001827 active site 46234001828 Schiff base residues; other site 46234001829 Tic20-like protein; Region: Tic20; pfam09685 46234001830 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 46234001831 metal binding site 2 [ion binding]; metal-binding site 46234001832 putative DNA binding helix; other site 46234001833 metal binding site 1 [ion binding]; metal-binding site 46234001834 dimer interface [polypeptide binding]; other site 46234001835 structural Zn2+ binding site [ion binding]; other site 46234001836 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 46234001837 catalytic triad [active] 46234001838 dimer interface [polypeptide binding]; other site 46234001839 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 46234001840 Phosphotransferase enzyme family; Region: APH; pfam01636 46234001841 substrate binding site [chemical binding]; other site 46234001842 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 46234001843 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 46234001844 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 46234001845 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 46234001846 active site 46234001847 dimer interface [polypeptide binding]; other site 46234001848 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 46234001849 dimer interface [polypeptide binding]; other site 46234001850 active site 46234001851 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 46234001852 active site 46234001853 dimer interface [polypeptide binding]; other site 46234001854 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 46234001855 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 46234001856 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 46234001857 TM-ABC transporter signature motif; other site 46234001858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234001859 putative active site [active] 46234001860 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 46234001861 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 46234001862 Walker A/P-loop; other site 46234001863 ATP binding site [chemical binding]; other site 46234001864 Q-loop/lid; other site 46234001865 ABC transporter signature motif; other site 46234001866 Walker B; other site 46234001867 D-loop; other site 46234001868 H-loop/switch region; other site 46234001869 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234001870 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 46234001871 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 46234001872 G1 box; other site 46234001873 GTP/Mg2+ binding site [chemical binding]; other site 46234001874 Switch I region; other site 46234001875 G2 box; other site 46234001876 Switch II region; other site 46234001877 G3 box; other site 46234001878 G4 box; other site 46234001879 G5 box; other site 46234001880 Domain of unknown function (DUF697); Region: DUF697; pfam05128 46234001881 CP12 domain; Region: CP12; pfam02672 46234001882 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234001883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234001884 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234001885 WD domain, G-beta repeat; Region: WD40; pfam00400 46234001886 WD domain, G-beta repeat; Region: WD40; pfam00400 46234001887 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234001888 structural tetrad; other site 46234001889 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234001890 structural tetrad; other site 46234001891 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 46234001892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234001893 RNA binding surface [nucleotide binding]; other site 46234001894 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 46234001895 Predicted membrane protein [Function unknown]; Region: COG4330 46234001896 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 46234001897 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 46234001898 G1 box; other site 46234001899 putative GEF interaction site [polypeptide binding]; other site 46234001900 GTP/Mg2+ binding site [chemical binding]; other site 46234001901 Switch I region; other site 46234001902 G2 box; other site 46234001903 G3 box; other site 46234001904 Switch II region; other site 46234001905 G4 box; other site 46234001906 G5 box; other site 46234001907 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 46234001908 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234001909 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 46234001910 RNA recognition motif; Region: RRM; smart00360 46234001911 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 46234001912 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 46234001913 putative ADP-binding pocket [chemical binding]; other site 46234001914 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 46234001915 Domain of unknown function (DUF814); Region: DUF814; pfam05670 46234001916 S-layer homology domain; Region: SLH; pfam00395 46234001917 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 46234001918 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 46234001919 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 46234001920 metal binding site [ion binding]; metal-binding site 46234001921 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 46234001922 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 46234001923 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 46234001924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 46234001925 ABC-ATPase subunit interface; other site 46234001926 dimer interface [polypeptide binding]; other site 46234001927 putative PBP binding regions; other site 46234001928 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 46234001929 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 46234001930 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234001931 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 46234001932 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 46234001933 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 46234001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 46234001935 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234001936 Calx-beta domain; Region: Calx-beta; cl02522 46234001937 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234001938 Predicted methyltransferases [General function prediction only]; Region: COG0313 46234001939 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 46234001940 putative SAM binding site [chemical binding]; other site 46234001941 putative homodimer interface [polypeptide binding]; other site 46234001942 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 46234001943 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 46234001944 substrate binding site [chemical binding]; other site 46234001945 ATP binding site [chemical binding]; other site 46234001946 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 46234001947 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 46234001948 active site 46234001949 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 46234001950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234001951 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 46234001952 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 46234001953 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 46234001954 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 46234001955 Walker A/P-loop; other site 46234001956 ATP binding site [chemical binding]; other site 46234001957 Q-loop/lid; other site 46234001958 ABC transporter signature motif; other site 46234001959 Walker B; other site 46234001960 D-loop; other site 46234001961 H-loop/switch region; other site 46234001962 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 46234001963 NMT1-like family; Region: NMT1_2; pfam13379 46234001964 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 46234001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234001966 dimer interface [polypeptide binding]; other site 46234001967 conserved gate region; other site 46234001968 putative PBP binding loops; other site 46234001969 ABC-ATPase subunit interface; other site 46234001970 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 46234001971 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 46234001972 dimerization interface [polypeptide binding]; other site 46234001973 active site 46234001974 metal binding site [ion binding]; metal-binding site 46234001975 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 46234001976 XisH protein; Region: XisH; pfam08814 46234001977 XisI protein; Region: XisI; pfam08869 46234001978 GUN4-like; Region: GUN4; pfam05419 46234001979 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 46234001980 isocitrate dehydrogenase; Validated; Region: PRK07362 46234001981 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 46234001982 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 46234001983 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 46234001984 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 46234001985 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 46234001986 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 46234001987 catalytic motif [active] 46234001988 Catalytic residue [active] 46234001989 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 46234001990 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 46234001991 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 46234001992 catalytic site [active] 46234001993 subunit interface [polypeptide binding]; other site 46234001994 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 46234001995 anti sigma factor interaction site; other site 46234001996 regulatory phosphorylation site [posttranslational modification]; other site 46234001997 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 46234001998 active site 46234001999 metal binding site [ion binding]; metal-binding site 46234002000 dimerization interface [polypeptide binding]; other site 46234002001 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 46234002002 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 46234002003 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 46234002004 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 46234002005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234002006 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 46234002007 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 46234002008 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 46234002009 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 46234002010 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 46234002011 catalytic residues [active] 46234002012 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 46234002013 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234002014 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234002015 TPR repeat; Region: TPR_11; pfam13414 46234002016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002017 TPR motif; other site 46234002018 binding surface 46234002019 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 46234002020 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 46234002021 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 46234002022 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 46234002023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 46234002024 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 46234002025 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 46234002026 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 46234002027 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234002028 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234002029 active site 46234002030 ATP binding site [chemical binding]; other site 46234002031 substrate binding site [chemical binding]; other site 46234002032 activation loop (A-loop); other site 46234002033 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234002034 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234002035 CAAX protease self-immunity; Region: Abi; pfam02517 46234002036 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 46234002037 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 46234002038 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 46234002039 B12 binding site [chemical binding]; other site 46234002040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234002041 FeS/SAM binding site; other site 46234002042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 46234002043 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 46234002044 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 46234002045 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 46234002046 homodimer interface [polypeptide binding]; other site 46234002047 oligonucleotide binding site [chemical binding]; other site 46234002048 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 46234002049 RNA/DNA hybrid binding site [nucleotide binding]; other site 46234002050 active site 46234002051 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 46234002052 prephenate dehydratase; Provisional; Region: PRK11898 46234002053 Prephenate dehydratase; Region: PDT; pfam00800 46234002054 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 46234002055 putative L-Phe binding site [chemical binding]; other site 46234002056 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 46234002057 active site 46234002058 catalytic triad [active] 46234002059 oxyanion hole [active] 46234002060 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 46234002061 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 46234002062 putative substrate binding pocket [chemical binding]; other site 46234002063 AC domain interface; other site 46234002064 catalytic triad [active] 46234002065 AB domain interface; other site 46234002066 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 46234002067 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 46234002068 putative active site [active] 46234002069 oxyanion strand; other site 46234002070 catalytic triad [active] 46234002071 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 46234002072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002073 S-adenosylmethionine binding site [chemical binding]; other site 46234002074 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 46234002075 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 46234002076 Cytochrome c; Region: Cytochrom_C; pfam00034 46234002077 Tubulin like; Region: Tubulin_2; pfam13809 46234002078 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 46234002079 ligand binding site [chemical binding]; other site 46234002080 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 46234002081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 46234002082 ATP binding site [chemical binding]; other site 46234002083 putative Mg++ binding site [ion binding]; other site 46234002084 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 46234002085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234002086 AAA domain; Region: AAA_21; pfam13304 46234002087 Walker A/P-loop; other site 46234002088 ATP binding site [chemical binding]; other site 46234002089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234002090 non-specific DNA binding site [nucleotide binding]; other site 46234002091 salt bridge; other site 46234002092 sequence-specific DNA binding site [nucleotide binding]; other site 46234002093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 46234002094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 46234002095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234002096 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 46234002097 putative NAD(P) binding site [chemical binding]; other site 46234002098 active site 46234002099 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 46234002100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234002101 putative ADP-binding pocket [chemical binding]; other site 46234002102 Bacterial sugar transferase; Region: Bac_transf; pfam02397 46234002103 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 46234002104 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 46234002105 NADP-binding site; other site 46234002106 homotetramer interface [polypeptide binding]; other site 46234002107 substrate binding site [chemical binding]; other site 46234002108 homodimer interface [polypeptide binding]; other site 46234002109 active site 46234002110 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 46234002111 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 46234002112 NADP binding site [chemical binding]; other site 46234002113 active site 46234002114 putative substrate binding site [chemical binding]; other site 46234002115 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 46234002116 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 46234002117 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 46234002118 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234002119 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 46234002120 active site clefts [active] 46234002121 zinc binding site [ion binding]; other site 46234002122 dimer interface [polypeptide binding]; other site 46234002123 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 46234002124 MPN+ (JAMM) motif; other site 46234002125 Zinc-binding site [ion binding]; other site 46234002126 hypothetical protein; Validated; Region: PRK07411 46234002127 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 46234002128 ATP binding site [chemical binding]; other site 46234002129 substrate interface [chemical binding]; other site 46234002130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 46234002131 active site residue [active] 46234002132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234002133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234002134 active site 46234002135 phosphorylation site [posttranslational modification] 46234002136 intermolecular recognition site; other site 46234002137 dimerization interface [polypeptide binding]; other site 46234002138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234002139 DNA binding site [nucleotide binding] 46234002140 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 46234002141 putative catalytic site [active] 46234002142 putative metal binding site [ion binding]; other site 46234002143 putative phosphate binding site [ion binding]; other site 46234002144 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 46234002145 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 46234002146 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 46234002147 Ycf39; Provisional; Region: ycf39; CHL00194 46234002148 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 46234002149 NAD(P) binding site [chemical binding]; other site 46234002150 putative active site [active] 46234002151 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 46234002152 ATP-NAD kinase; Region: NAD_kinase; pfam01513 46234002153 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 46234002154 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 46234002155 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 46234002156 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234002157 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234002158 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234002159 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234002160 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234002161 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234002162 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 46234002163 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234002164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234002165 active site 46234002166 ATP binding site [chemical binding]; other site 46234002167 substrate binding site [chemical binding]; other site 46234002168 activation loop (A-loop); other site 46234002169 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 46234002170 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 46234002171 Putative restriction endonuclease; Region: Uma2; pfam05685 46234002172 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 46234002173 XisH protein; Region: XisH; pfam08814 46234002174 XisI protein; Region: XisI; pfam08869 46234002175 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 46234002176 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 46234002177 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 46234002178 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 46234002179 RNA binding site [nucleotide binding]; other site 46234002180 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 46234002181 Part of AAA domain; Region: AAA_19; pfam13245 46234002182 Predicted membrane protein [Function unknown]; Region: COG1950 46234002183 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 46234002184 cytochrome c6; Provisional; Region: PRK13697 46234002185 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 46234002186 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 46234002187 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 46234002188 active site 46234002189 catalytic tetrad [active] 46234002190 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002191 putative active site [active] 46234002192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234002193 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 46234002194 active site 46234002195 metal binding site [ion binding]; metal-binding site 46234002196 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 46234002197 active site 46234002198 metal binding site [ion binding]; metal-binding site 46234002199 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 46234002200 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234002201 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234002202 active site 46234002203 ATP binding site [chemical binding]; other site 46234002204 substrate binding site [chemical binding]; other site 46234002205 activation loop (A-loop); other site 46234002206 Bacterial SH3 domain homologues; Region: SH3b; smart00287 46234002207 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002208 putative active site [active] 46234002209 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 46234002210 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 46234002211 protein binding surface [polypeptide binding]; other site 46234002212 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 46234002213 protein binding surface [polypeptide binding]; other site 46234002214 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 46234002215 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 46234002216 protein binding surface [polypeptide binding]; other site 46234002217 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 46234002218 protein binding surface [polypeptide binding]; other site 46234002219 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 46234002220 protein binding surface [polypeptide binding]; other site 46234002221 XisI protein; Region: XisI; pfam08869 46234002222 Amidinotransferase; Region: Amidinotransf; cl12043 46234002223 PIN domain; Region: PIN; pfam01850 46234002224 putative active site [active] 46234002225 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 46234002226 active site flap/lid [active] 46234002227 nucleophilic elbow; other site 46234002228 catalytic triad [active] 46234002229 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 46234002230 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234002231 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 46234002232 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 46234002233 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 46234002234 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 46234002235 substrate binding site [chemical binding]; other site 46234002236 active site 46234002237 catalytic residues [active] 46234002238 heterodimer interface [polypeptide binding]; other site 46234002239 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 46234002240 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 46234002241 ChaB; Region: ChaB; cl01887 46234002242 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 46234002243 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 46234002244 NodB motif; other site 46234002245 active site 46234002246 catalytic site [active] 46234002247 metal binding site [ion binding]; metal-binding site 46234002248 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234002249 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234002250 active site 46234002251 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 46234002252 ABC1 family; Region: ABC1; cl17513 46234002253 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 46234002254 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 46234002255 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 46234002256 TrkA-N domain; Region: TrkA_N; pfam02254 46234002257 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 46234002258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 46234002259 active site 46234002260 catalytic tetrad [active] 46234002261 prolyl-tRNA synthetase; Provisional; Region: PRK09194 46234002262 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 46234002263 dimer interface [polypeptide binding]; other site 46234002264 motif 1; other site 46234002265 active site 46234002266 motif 2; other site 46234002267 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 46234002268 putative deacylase active site [active] 46234002269 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 46234002270 active site 46234002271 motif 3; other site 46234002272 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 46234002273 anticodon binding site; other site 46234002274 Phosphate acyltransferases; Region: PlsC; smart00563 46234002275 PIN domain; Region: PIN; pfam01850 46234002276 putative active site [active] 46234002277 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 46234002278 dimer interface [polypeptide binding]; other site 46234002279 [2Fe-2S] cluster binding site [ion binding]; other site 46234002280 NifT/FixU protein; Region: NifT; pfam06988 46234002281 NifZ domain; Region: NifZ; pfam04319 46234002282 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 46234002283 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 46234002284 active site 46234002285 catalytic residues [active] 46234002286 metal binding site [ion binding]; metal-binding site 46234002287 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 46234002288 serine O-acetyltransferase; Region: cysE; TIGR01172 46234002289 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 46234002290 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 46234002291 trimer interface [polypeptide binding]; other site 46234002292 active site 46234002293 substrate binding site [chemical binding]; other site 46234002294 CoA binding site [chemical binding]; other site 46234002295 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 46234002296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 46234002297 threonine dehydratase; Reviewed; Region: PRK09224 46234002298 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 46234002299 tetramer interface [polypeptide binding]; other site 46234002300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234002301 catalytic residue [active] 46234002302 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 46234002303 putative Ile/Val binding site [chemical binding]; other site 46234002304 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 46234002305 putative Ile/Val binding site [chemical binding]; other site 46234002306 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 46234002307 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 46234002308 hydrolase, alpha/beta fold family protein; Region: PLN02824 46234002309 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 46234002310 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 46234002311 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 46234002312 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 46234002313 shikimate binding site; other site 46234002314 NAD(P) binding site [chemical binding]; other site 46234002315 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 46234002316 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 46234002317 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 46234002318 CoA binding domain; Region: CoA_binding; smart00881 46234002319 CoA-ligase; Region: Ligase_CoA; pfam00549 46234002320 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 46234002321 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 46234002322 iron-sulfur cluster [ion binding]; other site 46234002323 [2Fe-2S] cluster binding site [ion binding]; other site 46234002324 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 46234002325 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 46234002326 metal-binding site [ion binding] 46234002327 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234002328 Soluble P-type ATPase [General function prediction only]; Region: COG4087 46234002329 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 46234002330 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 46234002331 active site 46234002332 Zn binding site [ion binding]; other site 46234002333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 46234002334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 46234002335 membrane protein; Provisional; Region: PRK14419 46234002336 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 46234002337 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 46234002338 Permease; Region: Permease; cl00510 46234002339 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 46234002340 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 46234002341 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 46234002342 tandem repeat interface [polypeptide binding]; other site 46234002343 oligomer interface [polypeptide binding]; other site 46234002344 active site residues [active] 46234002345 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 46234002346 homotrimer interaction site [polypeptide binding]; other site 46234002347 active site 46234002348 YcfA-like protein; Region: YcfA; pfam07927 46234002349 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234002350 Peptidase M30; Region: Peptidase_M30; pfam10460 46234002351 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234002352 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 46234002353 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 46234002354 putative di-iron ligands [ion binding]; other site 46234002355 pyruvate kinase; Provisional; Region: PRK06354 46234002356 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 46234002357 domain interfaces; other site 46234002358 active site 46234002359 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 46234002360 chaperone protein DnaJ; Provisional; Region: PRK14299 46234002361 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234002362 HSP70 interaction site [polypeptide binding]; other site 46234002363 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 46234002364 substrate binding site [polypeptide binding]; other site 46234002365 dimer interface [polypeptide binding]; other site 46234002366 AAA domain; Region: AAA_33; pfam13671 46234002367 AAA domain; Region: AAA_17; pfam13207 46234002368 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 46234002369 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 46234002370 ligand binding site; other site 46234002371 oligomer interface; other site 46234002372 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 46234002373 dimer interface [polypeptide binding]; other site 46234002374 N-terminal domain interface [polypeptide binding]; other site 46234002375 sulfate 1 binding site; other site 46234002376 DNA methylase; Region: N6_N4_Mtase; cl17433 46234002377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 46234002378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234002379 non-specific DNA binding site [nucleotide binding]; other site 46234002380 salt bridge; other site 46234002381 sequence-specific DNA binding site [nucleotide binding]; other site 46234002382 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002383 putative active site [active] 46234002384 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234002385 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234002386 structural tetrad; other site 46234002387 Interferon-induced transmembrane protein; Region: CD225; pfam04505 46234002388 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 46234002389 recombination protein RecR; Reviewed; Region: recR; PRK00076 46234002390 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 46234002391 RecR protein; Region: RecR; pfam02132 46234002392 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 46234002393 putative active site [active] 46234002394 putative metal-binding site [ion binding]; other site 46234002395 tetramer interface [polypeptide binding]; other site 46234002396 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234002397 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234002398 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234002399 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 46234002400 active site 46234002401 dinuclear metal binding site [ion binding]; other site 46234002402 dimerization interface [polypeptide binding]; other site 46234002403 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 46234002404 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 46234002405 mercuric reductase; Validated; Region: PRK06370 46234002406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 46234002407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234002408 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 46234002409 Uncharacterized conserved protein [Function unknown]; Region: COG0398 46234002410 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 46234002411 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 46234002412 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 46234002413 Probable Catalytic site; other site 46234002414 RRXRR protein; Region: RRXRR; pfam14239 46234002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234002416 Walker A motif; other site 46234002417 ATP binding site [chemical binding]; other site 46234002418 Walker B motif; other site 46234002419 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234002420 protein-splicing catalytic site; other site 46234002421 thioester formation/cholesterol transfer; other site 46234002422 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 46234002423 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234002424 protein-splicing catalytic site; other site 46234002425 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 46234002426 DNA polymerase III subunit delta'; Validated; Region: PRK08485 46234002427 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 46234002428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002429 binding surface 46234002430 TPR motif; other site 46234002431 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234002432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002433 binding surface 46234002434 TPR motif; other site 46234002435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002436 binding surface 46234002437 TPR motif; other site 46234002438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002439 binding surface 46234002440 TPR motif; other site 46234002441 CHAT domain; Region: CHAT; cl17868 46234002442 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 46234002443 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 46234002444 PemK-like protein; Region: PemK; pfam02452 46234002445 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 46234002446 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 46234002447 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 46234002448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 46234002449 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 46234002450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 46234002451 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 46234002452 catalytic site [active] 46234002453 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 46234002454 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 46234002455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234002456 NAD(P) binding site [chemical binding]; other site 46234002457 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 46234002458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234002459 NADH(P)-binding; Region: NAD_binding_10; pfam13460 46234002460 active site 46234002461 Uncharacterized conserved protein [Function unknown]; Region: COG3791 46234002462 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 46234002463 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002464 putative active site [active] 46234002465 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 46234002466 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 46234002467 domain interfaces; other site 46234002468 active site 46234002469 glycogen synthase; Provisional; Region: glgA; PRK00654 46234002470 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 46234002471 ADP-binding pocket [chemical binding]; other site 46234002472 homodimer interface [polypeptide binding]; other site 46234002473 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 46234002474 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 46234002475 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 46234002476 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 46234002477 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 46234002478 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 46234002479 ligand binding site [chemical binding]; other site 46234002480 NAD binding site [chemical binding]; other site 46234002481 dimerization interface [polypeptide binding]; other site 46234002482 catalytic site [active] 46234002483 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 46234002484 aspartate racemase; Region: asp_race; TIGR00035 46234002485 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234002486 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 46234002487 active site 46234002488 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234002489 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 46234002490 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234002492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002493 S-adenosylmethionine binding site [chemical binding]; other site 46234002494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 46234002495 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 46234002496 inhibitor-cofactor binding pocket; inhibition site 46234002497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234002498 catalytic residue [active] 46234002499 Condensation domain; Region: Condensation; pfam00668 46234002500 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002501 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002503 acyl-activating enzyme (AAE) consensus motif; other site 46234002504 AMP binding site [chemical binding]; other site 46234002505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002506 Condensation domain; Region: Condensation; pfam00668 46234002507 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002508 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002509 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234002510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002511 S-adenosylmethionine binding site [chemical binding]; other site 46234002512 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234002513 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 46234002514 active site 46234002515 Acyl transferase domain; Region: Acyl_transf_1; cl08282 46234002516 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 46234002517 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002519 S-adenosylmethionine binding site [chemical binding]; other site 46234002520 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 46234002521 KR domain; Region: KR; pfam08659 46234002522 putative NADP binding site [chemical binding]; other site 46234002523 active site 46234002524 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 46234002525 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 46234002526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234002527 active site 46234002528 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 46234002529 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 46234002530 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 46234002531 KR domain; Region: KR; pfam08659 46234002532 putative NADP binding site [chemical binding]; other site 46234002533 active site 46234002534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 46234002535 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 46234002536 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 46234002537 acyl-activating enzyme (AAE) consensus motif; other site 46234002538 putative AMP binding site [chemical binding]; other site 46234002539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002540 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234002541 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 46234002542 active site 46234002543 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234002544 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 46234002545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234002546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002547 S-adenosylmethionine binding site [chemical binding]; other site 46234002548 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 46234002549 KR domain; Region: KR; pfam08659 46234002550 putative NADP binding site [chemical binding]; other site 46234002551 active site 46234002552 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 46234002553 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002554 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234002555 acyl-activating enzyme (AAE) consensus motif; other site 46234002556 AMP binding site [chemical binding]; other site 46234002557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002558 S-adenosylmethionine binding site [chemical binding]; other site 46234002559 Microcystin synthetase C terminal; Region: McyA_C; pfam12593 46234002560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234002561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002562 Condensation domain; Region: Condensation; pfam00668 46234002563 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002564 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 46234002565 acyl-activating enzyme (AAE) consensus motif; other site 46234002566 AMP binding site [chemical binding]; other site 46234002567 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002568 Condensation domain; Region: Condensation; pfam00668 46234002569 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002570 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234002571 Condensation domain; Region: Condensation; pfam00668 46234002572 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002573 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002574 acyl-activating enzyme (AAE) consensus motif; other site 46234002575 AMP binding site [chemical binding]; other site 46234002576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002577 Condensation domain; Region: Condensation; pfam00668 46234002578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002579 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234002581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234002582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002583 acyl-activating enzyme (AAE) consensus motif; other site 46234002584 acyl-activating enzyme (AAE) consensus motif; other site 46234002585 AMP binding site [chemical binding]; other site 46234002586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002587 Condensation domain; Region: Condensation; pfam00668 46234002588 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002589 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002590 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002591 acyl-activating enzyme (AAE) consensus motif; other site 46234002592 AMP binding site [chemical binding]; other site 46234002593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002594 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 46234002595 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 46234002596 active site 46234002597 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 46234002598 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 46234002599 active site 46234002600 SAM binding site [chemical binding]; other site 46234002601 homodimer interface [polypeptide binding]; other site 46234002602 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 46234002603 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 46234002604 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 46234002605 active site 46234002606 (T/H)XGH motif; other site 46234002607 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 46234002608 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 46234002609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 46234002610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002612 binding surface 46234002613 TPR motif; other site 46234002614 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002616 binding surface 46234002617 TPR motif; other site 46234002618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002621 binding surface 46234002622 TPR motif; other site 46234002623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002624 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 46234002625 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 46234002626 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 46234002627 SmpB-tmRNA interface; other site 46234002628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234002630 active site 46234002631 phosphorylation site [posttranslational modification] 46234002632 intermolecular recognition site; other site 46234002633 dimerization interface [polypeptide binding]; other site 46234002634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234002635 DNA binding residues [nucleotide binding] 46234002636 dimerization interface [polypeptide binding]; other site 46234002637 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 46234002638 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 46234002639 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 46234002640 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 46234002641 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 46234002642 Ion channel; Region: Ion_trans_2; pfam07885 46234002643 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 46234002644 TrkA-N domain; Region: TrkA_N; pfam02254 46234002645 TrkA-C domain; Region: TrkA_C; pfam02080 46234002646 acetylornithine aminotransferase; Provisional; Region: PRK02627 46234002647 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 46234002648 inhibitor-cofactor binding pocket; inhibition site 46234002649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234002650 catalytic residue [active] 46234002651 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 46234002652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 46234002653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234002654 non-specific DNA binding site [nucleotide binding]; other site 46234002655 salt bridge; other site 46234002656 sequence-specific DNA binding site [nucleotide binding]; other site 46234002657 Restriction endonuclease PvuII; Region: Endonuc-PvuII; pfam09225 46234002658 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234002659 DNA methylase; Region: N6_N4_Mtase; pfam01555 46234002660 S-layer homology domain; Region: SLH; pfam00395 46234002661 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 46234002662 hypothetical protein; Provisional; Region: PRK10621 46234002663 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 46234002664 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 46234002665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234002666 FeS/SAM binding site; other site 46234002667 phosphodiesterase YaeI; Provisional; Region: PRK11340 46234002668 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 46234002669 putative active site [active] 46234002670 putative metal binding site [ion binding]; other site 46234002671 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234002672 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234002673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234002674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234002675 DNA binding residues [nucleotide binding] 46234002676 dimerization interface [polypeptide binding]; other site 46234002677 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 46234002678 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 46234002679 tartrate dehydrogenase; Region: TTC; TIGR02089 46234002680 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 46234002681 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 46234002682 substrate binding site [chemical binding]; other site 46234002683 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 46234002684 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 46234002685 substrate binding site [chemical binding]; other site 46234002686 ligand binding site [chemical binding]; other site 46234002687 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002688 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234002689 acyl-activating enzyme (AAE) consensus motif; other site 46234002690 AMP binding site [chemical binding]; other site 46234002691 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002692 Condensation domain; Region: Condensation; pfam00668 46234002693 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002694 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002695 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002696 acyl-activating enzyme (AAE) consensus motif; other site 46234002697 AMP binding site [chemical binding]; other site 46234002698 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002699 Condensation domain; Region: Condensation; pfam00668 46234002700 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002701 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234002702 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002703 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234002704 acyl-activating enzyme (AAE) consensus motif; other site 46234002705 AMP binding site [chemical binding]; other site 46234002706 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002707 Condensation domain; Region: Condensation; pfam00668 46234002708 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002709 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002710 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002711 acyl-activating enzyme (AAE) consensus motif; other site 46234002712 AMP binding site [chemical binding]; other site 46234002713 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002714 Condensation domain; Region: Condensation; pfam00668 46234002715 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002716 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234002717 Condensation domain; Region: Condensation; pfam00668 46234002718 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002719 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 46234002720 acyl-activating enzyme (AAE) consensus motif; other site 46234002721 AMP binding site [chemical binding]; other site 46234002722 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002723 Condensation domain; Region: Condensation; pfam00668 46234002724 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002725 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002726 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002727 acyl-activating enzyme (AAE) consensus motif; other site 46234002728 AMP binding site [chemical binding]; other site 46234002729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002730 Condensation domain; Region: Condensation; pfam00668 46234002731 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002732 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002733 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 46234002734 acyl-activating enzyme (AAE) consensus motif; other site 46234002735 AMP binding site [chemical binding]; other site 46234002736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234002737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002738 S-adenosylmethionine binding site [chemical binding]; other site 46234002739 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234002740 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002741 Condensation domain; Region: Condensation; pfam00668 46234002742 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234002743 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234002744 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234002745 acyl-activating enzyme (AAE) consensus motif; other site 46234002746 AMP binding site [chemical binding]; other site 46234002747 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234002748 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 46234002749 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 46234002750 active site 46234002751 catalytic residues [active] 46234002752 metal binding site [ion binding]; metal-binding site 46234002753 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 46234002754 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 46234002755 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 46234002756 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 46234002757 GUN4-like; Region: GUN4; pfam05419 46234002758 aspartate aminotransferase; Provisional; Region: PRK05764 46234002759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234002760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234002761 homodimer interface [polypeptide binding]; other site 46234002762 catalytic residue [active] 46234002763 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234002764 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 46234002765 putative metal binding site; other site 46234002766 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234002767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234002768 TPR motif; other site 46234002769 TPR repeat; Region: TPR_11; pfam13414 46234002770 binding surface 46234002771 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 46234002772 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 46234002773 GIY-YIG motif/motif A; other site 46234002774 active site 46234002775 catalytic site [active] 46234002776 putative DNA binding site [nucleotide binding]; other site 46234002777 metal binding site [ion binding]; metal-binding site 46234002778 UvrB/uvrC motif; Region: UVR; pfam02151 46234002779 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 46234002780 hypothetical protein; Validated; Region: PRK00110 46234002781 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002782 putative active site [active] 46234002783 glucokinase; Provisional; Region: glk; PRK00292 46234002784 glucokinase, proteobacterial type; Region: glk; TIGR00749 46234002785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 46234002786 catalytic core [active] 46234002787 aspartate aminotransferase; Provisional; Region: PRK05957 46234002788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234002790 homodimer interface [polypeptide binding]; other site 46234002791 catalytic residue [active] 46234002792 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 46234002793 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002794 putative active site [active] 46234002795 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234002796 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234002797 Transposase IS200 like; Region: Y1_Tnp; cl00848 46234002798 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 46234002799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234002800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234002801 ketol-acid reductoisomerase; Provisional; Region: PRK05479 46234002802 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 46234002803 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 46234002804 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 46234002805 Amidase; Region: Amidase; pfam01425 46234002806 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 46234002807 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 46234002808 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 46234002809 putative active site [active] 46234002810 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 46234002811 putative active site [active] 46234002812 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 46234002813 active site 46234002814 SAM binding site [chemical binding]; other site 46234002815 homodimer interface [polypeptide binding]; other site 46234002816 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234002817 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234002818 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 46234002819 Uncharacterized conserved protein [Function unknown]; Region: COG2442 46234002820 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 46234002821 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 46234002822 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234002823 putative active site [active] 46234002824 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 46234002825 putative addiction module antidote; Region: doc_partner; TIGR02609 46234002826 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 46234002827 Response regulator receiver domain; Region: Response_reg; pfam00072 46234002828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234002829 active site 46234002830 phosphorylation site [posttranslational modification] 46234002831 intermolecular recognition site; other site 46234002832 dimerization interface [polypeptide binding]; other site 46234002833 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 46234002834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234002835 RNA binding surface [nucleotide binding]; other site 46234002836 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 46234002837 active site 46234002838 Phycobilisome protein; Region: Phycobilisome; cl08227 46234002839 phycocyanin alpha subunit; Reviewed; Region: cpcA; CHL00170 46234002840 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234002841 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 46234002842 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 46234002843 HEAT repeats; Region: HEAT_2; pfam13646 46234002844 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 46234002845 HEAT repeats; Region: HEAT_2; pfam13646 46234002846 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 46234002847 HEAT repeats; Region: HEAT_2; pfam13646 46234002848 HEAT repeats; Region: HEAT_2; pfam13646 46234002849 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234002850 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234002851 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234002852 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234002853 methionine sulfoxide reductase B; Provisional; Region: PRK00222 46234002854 SelR domain; Region: SelR; pfam01641 46234002855 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 46234002856 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 46234002857 putative active site [active] 46234002858 putative dimer interface [polypeptide binding]; other site 46234002859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 46234002860 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 46234002861 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 46234002862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 46234002863 sulfate transport protein; Provisional; Region: cysT; CHL00187 46234002864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234002865 dimer interface [polypeptide binding]; other site 46234002866 conserved gate region; other site 46234002867 putative PBP binding loops; other site 46234002868 ABC-ATPase subunit interface; other site 46234002869 sulfate transport protein; Provisional; Region: cysT; CHL00187 46234002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234002871 dimer interface [polypeptide binding]; other site 46234002872 conserved gate region; other site 46234002873 putative PBP binding loops; other site 46234002874 ABC-ATPase subunit interface; other site 46234002875 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 46234002876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234002877 Probable transposase; Region: OrfB_IS605; pfam01385 46234002878 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234002879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234002880 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 46234002881 Walker A/P-loop; other site 46234002882 ATP binding site [chemical binding]; other site 46234002883 ABC transporter; Region: ABC_tran; pfam00005 46234002884 Q-loop/lid; other site 46234002885 ABC transporter signature motif; other site 46234002886 Walker B; other site 46234002887 D-loop; other site 46234002888 H-loop/switch region; other site 46234002889 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 46234002890 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 46234002891 dimer interface [polypeptide binding]; other site 46234002892 ADP-ribose binding site [chemical binding]; other site 46234002893 active site 46234002894 nudix motif; other site 46234002895 metal binding site [ion binding]; metal-binding site 46234002896 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 46234002897 catalytic center binding site [active] 46234002898 ATP binding site [chemical binding]; other site 46234002899 Transglycosylase; Region: Transgly; pfam00912 46234002900 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 46234002901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 46234002902 16S rRNA methyltransferase B; Provisional; Region: PRK14901 46234002903 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 46234002904 putative RNA binding site [nucleotide binding]; other site 46234002905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234002906 S-adenosylmethionine binding site [chemical binding]; other site 46234002907 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 46234002908 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 46234002909 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 46234002910 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234002911 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 46234002912 putative active site [active] 46234002913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234002914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234002915 Walker A/P-loop; other site 46234002916 ATP binding site [chemical binding]; other site 46234002917 Q-loop/lid; other site 46234002918 ABC transporter signature motif; other site 46234002919 Walker B; other site 46234002920 D-loop; other site 46234002921 H-loop/switch region; other site 46234002922 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 46234002923 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 46234002924 nucleotide binding site [chemical binding]; other site 46234002925 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 46234002926 putative dimer interface [polypeptide binding]; other site 46234002927 putative [2Fe-2S] cluster binding site [ion binding]; other site 46234002928 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 46234002929 Repair protein; Region: Repair_PSII; pfam04536 46234002930 precorrin-8X methylmutase; Validated; Region: PRK05953 46234002931 Precorrin-8X methylmutase; Region: CbiC; pfam02570 46234002932 dihydrodipicolinate reductase; Provisional; Region: PRK00048 46234002933 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 46234002934 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 46234002935 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 46234002936 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 46234002937 nucleotide binding site [chemical binding]; other site 46234002938 putative NEF/HSP70 interaction site [polypeptide binding]; other site 46234002939 SBD interface [polypeptide binding]; other site 46234002940 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 46234002941 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 46234002942 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 46234002943 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 46234002944 Ycf46; Provisional; Region: ycf46; CHL00195 46234002945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234002946 Walker A motif; other site 46234002947 ATP binding site [chemical binding]; other site 46234002948 Walker B motif; other site 46234002949 arginine finger; other site 46234002950 HEAT repeats; Region: HEAT_2; pfam13646 46234002951 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234002952 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234002953 HEPN domain; Region: HEPN; cl00824 46234002954 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 46234002955 active site 46234002956 NTP binding site [chemical binding]; other site 46234002957 metal binding triad [ion binding]; metal-binding site 46234002958 antibiotic binding site [chemical binding]; other site 46234002959 stationary phase growth adaptation protein; Provisional; Region: PRK09717 46234002960 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 46234002961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 46234002962 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 46234002963 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 46234002964 active site 46234002965 HIGH motif; other site 46234002966 KMSKS motif; other site 46234002967 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 46234002968 anticodon binding site; other site 46234002969 tRNA binding surface [nucleotide binding]; other site 46234002970 Uncharacterized conserved protein [Function unknown]; Region: COG1432 46234002971 LabA_like proteins; Region: LabA; cd10911 46234002972 putative metal binding site [ion binding]; other site 46234002973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 46234002974 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 46234002975 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 46234002976 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 46234002977 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 46234002978 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234002979 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234002980 catalytic residues [active] 46234002981 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 46234002982 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 46234002983 active site 46234002984 Uncharacterized conserved protein [Function unknown]; Region: COG1434 46234002985 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 46234002986 putative active site [active] 46234002987 AAA ATPase domain; Region: AAA_16; pfam13191 46234002988 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234002989 structural tetrad; other site 46234002990 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234002991 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234002992 structural tetrad; other site 46234002993 AAA ATPase domain; Region: AAA_16; pfam13191 46234002994 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 46234002995 Domain of unknown function DUF20; Region: UPF0118; pfam01594 46234002996 2TM domain; Region: 2TM; pfam13239 46234002997 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 46234002998 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234002999 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 46234003000 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 46234003001 GIY-YIG motif/motif A; other site 46234003002 putative active site [active] 46234003003 putative metal binding site [ion binding]; other site 46234003004 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 46234003005 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234003006 homoserine kinase; Provisional; Region: PRK01212 46234003007 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 46234003008 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 46234003009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234003010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003011 active site 46234003012 ATP binding site [chemical binding]; other site 46234003013 substrate binding site [chemical binding]; other site 46234003014 activation loop (A-loop); other site 46234003015 TPR repeat; Region: TPR_11; pfam13414 46234003016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003017 binding surface 46234003018 TPR motif; other site 46234003019 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234003020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003021 binding surface 46234003022 TPR motif; other site 46234003023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003024 binding surface 46234003025 TPR motif; other site 46234003026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003027 binding surface 46234003028 TPR motif; other site 46234003029 This domain is found in peptide chain release factors; Region: PCRF; smart00937 46234003030 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 46234003031 RF-1 domain; Region: RF-1; pfam00472 46234003032 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 46234003033 metal-binding heat shock protein; Provisional; Region: PRK00016 46234003034 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 46234003035 four helix bundle protein; Region: TIGR02436 46234003036 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 46234003037 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 46234003038 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 46234003039 glutamine binding [chemical binding]; other site 46234003040 catalytic triad [active] 46234003041 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 46234003042 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 46234003043 Family description; Region: VCBS; pfam13517 46234003044 Family description; Region: VCBS; pfam13517 46234003045 Family description; Region: VCBS; pfam13517 46234003046 Family description; Region: VCBS; pfam13517 46234003047 Family description; Region: VCBS; pfam13517 46234003048 proline aminopeptidase P II; Provisional; Region: PRK10879 46234003049 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 46234003050 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 46234003051 active site 46234003052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234003053 AAA domain; Region: AAA_22; pfam13401 46234003054 Walker A motif; other site 46234003055 ATP binding site [chemical binding]; other site 46234003056 Walker B motif; other site 46234003057 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234003058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234003059 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 46234003060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234003061 Coenzyme A binding pocket [chemical binding]; other site 46234003062 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234003063 UGMP family protein; Validated; Region: PRK09604 46234003064 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 46234003065 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 46234003066 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 46234003067 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 46234003068 putative phosphoketolase; Provisional; Region: PRK05261 46234003069 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 46234003070 TPP-binding site; other site 46234003071 XFP C-terminal domain; Region: XFP_C; pfam09363 46234003072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003073 binding surface 46234003074 TPR motif; other site 46234003075 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234003076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003077 binding surface 46234003078 TPR motif; other site 46234003079 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234003080 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234003081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003082 binding surface 46234003083 TPR motif; other site 46234003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 46234003085 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 46234003086 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 46234003087 MoxR-like ATPases [General function prediction only]; Region: COG0714 46234003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234003089 ATP binding site [chemical binding]; other site 46234003090 Walker A motif; other site 46234003091 Walker B motif; other site 46234003092 arginine finger; other site 46234003093 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 46234003094 Protein of unknown function DUF58; Region: DUF58; pfam01882 46234003095 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 46234003096 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 46234003097 Predicted membrane protein/domain [Function unknown]; Region: COG1714 46234003098 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 46234003099 DNA polymerase III subunit delta; Validated; Region: PRK07452 46234003100 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 46234003101 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 46234003102 K+ potassium transporter; Region: K_trans; cl15781 46234003103 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 46234003104 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 46234003105 GIY-YIG motif/motif A; other site 46234003106 active site 46234003107 catalytic site [active] 46234003108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 46234003109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234003110 dimer interface [polypeptide binding]; other site 46234003111 putative metal binding site [ion binding]; other site 46234003112 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 46234003113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 46234003114 active site 46234003115 nucleotide binding site [chemical binding]; other site 46234003116 HIGH motif; other site 46234003117 KMSKS motif; other site 46234003118 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 46234003119 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 46234003120 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 46234003121 ABC1 family; Region: ABC1; cl17513 46234003122 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 46234003123 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 46234003124 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 46234003125 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 46234003126 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 46234003127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 46234003128 Walker A motif; other site 46234003129 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234003130 protein-splicing catalytic site; other site 46234003131 thioester formation/cholesterol transfer; other site 46234003132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234003133 non-specific DNA binding site [nucleotide binding]; other site 46234003134 salt bridge; other site 46234003135 sequence-specific DNA binding site [nucleotide binding]; other site 46234003136 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234003137 protein-splicing catalytic site; other site 46234003138 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 46234003139 Walker B motif; other site 46234003140 DNA binding loops [nucleotide binding] 46234003141 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234003142 protein-splicing catalytic site; other site 46234003143 thioester formation/cholesterol transfer; other site 46234003144 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 46234003145 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 46234003146 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 46234003147 NurA nuclease; Region: NurA; smart00933 46234003148 TPR repeat; Region: TPR_11; pfam13414 46234003149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003150 binding surface 46234003151 TPR motif; other site 46234003152 TPR repeat; Region: TPR_11; pfam13414 46234003153 TPR repeat; Region: TPR_11; pfam13414 46234003154 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 46234003155 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234003156 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234003157 phosphopeptide binding site; other site 46234003158 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 46234003159 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003160 GUN4-like; Region: GUN4; pfam05419 46234003161 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003162 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234003163 Transposase IS200 like; Region: Y1_Tnp; pfam01797 46234003164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234003165 Probable transposase; Region: OrfB_IS605; pfam01385 46234003166 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234003167 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234003168 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003169 active site 46234003170 ATP binding site [chemical binding]; other site 46234003171 substrate binding site [chemical binding]; other site 46234003172 activation loop (A-loop); other site 46234003173 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 46234003174 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 46234003175 ABC-ATPase subunit interface; other site 46234003176 dimer interface [polypeptide binding]; other site 46234003177 putative PBP binding regions; other site 46234003178 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 46234003179 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 46234003180 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 46234003181 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 46234003182 metal binding site [ion binding]; metal-binding site 46234003183 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 46234003184 diiron binding motif [ion binding]; other site 46234003185 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 46234003186 heme binding pocket [chemical binding]; other site 46234003187 heme ligand [chemical binding]; other site 46234003188 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 46234003189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234003190 FeS/SAM binding site; other site 46234003191 HemN C-terminal domain; Region: HemN_C; pfam06969 46234003192 Predicted membrane protein [Function unknown]; Region: COG2261 46234003193 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 46234003194 Peptidase family M50; Region: Peptidase_M50; pfam02163 46234003195 active site 46234003196 putative substrate binding region [chemical binding]; other site 46234003197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 46234003198 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003199 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 46234003200 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 46234003201 active site 46234003202 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 46234003203 homodecamer interface [polypeptide binding]; other site 46234003204 GTP cyclohydrolase I; Provisional; Region: PLN03044 46234003205 active site 46234003206 putative catalytic site residues [active] 46234003207 zinc binding site [ion binding]; other site 46234003208 GTP-CH-I/GFRP interaction surface; other site 46234003209 short chain dehydrogenase; Provisional; Region: PRK07454 46234003210 classical (c) SDRs; Region: SDR_c; cd05233 46234003211 NAD(P) binding site [chemical binding]; other site 46234003212 active site 46234003213 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 46234003214 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 46234003215 acyl-ACP reductase; Provisional; Region: PRK14982 46234003216 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 46234003217 NAD(P) binding pocket [chemical binding]; other site 46234003218 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 46234003219 dinuclear metal binding motif [ion binding]; other site 46234003220 PIN domain; Region: PIN_3; cl17397 46234003221 XisI protein; Region: XisI; pfam08869 46234003222 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 46234003223 aromatic arch; other site 46234003224 DCoH dimer interaction site [polypeptide binding]; other site 46234003225 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 46234003226 DCoH tetramer interaction site [polypeptide binding]; other site 46234003227 substrate binding site [chemical binding]; other site 46234003228 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 46234003229 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 46234003230 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 46234003231 homodimer interface [polypeptide binding]; other site 46234003232 NADP binding site [chemical binding]; other site 46234003233 substrate binding site [chemical binding]; other site 46234003234 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 46234003235 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 46234003236 substrate binding pocket [chemical binding]; other site 46234003237 chain length determination region; other site 46234003238 substrate-Mg2+ binding site; other site 46234003239 catalytic residues [active] 46234003240 aspartate-rich region 1; other site 46234003241 active site lid residues [active] 46234003242 aspartate-rich region 2; other site 46234003243 Divergent PAP2 family; Region: DUF212; pfam02681 46234003244 Predicted permeases [General function prediction only]; Region: COG0795 46234003245 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 46234003246 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 46234003247 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 46234003248 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 46234003249 active site 46234003250 hydrophilic channel; other site 46234003251 dimerization interface [polypeptide binding]; other site 46234003252 catalytic residues [active] 46234003253 active site lid [active] 46234003254 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234003255 putative active site [active] 46234003256 Caspase domain; Region: Peptidase_C14; pfam00656 46234003257 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 46234003258 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234003259 putative ligand binding site [chemical binding]; other site 46234003260 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234003261 putative active site [active] 46234003262 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 46234003263 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 46234003264 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 46234003265 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234003266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234003267 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 46234003268 Walker A/P-loop; other site 46234003269 ATP binding site [chemical binding]; other site 46234003270 Q-loop/lid; other site 46234003271 ABC transporter signature motif; other site 46234003272 Walker B; other site 46234003273 D-loop; other site 46234003274 H-loop/switch region; other site 46234003275 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 46234003276 ligand binding surface [chemical binding]; other site 46234003277 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234003278 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234003279 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234003280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234003281 sequence-specific DNA binding site [nucleotide binding]; other site 46234003282 salt bridge; other site 46234003283 Peptidase family M48; Region: Peptidase_M48; cl12018 46234003284 2TM domain; Region: 2TM; pfam13239 46234003285 peptide chain release factor 1; Validated; Region: prfA; PRK00591 46234003286 This domain is found in peptide chain release factors; Region: PCRF; smart00937 46234003287 RF-1 domain; Region: RF-1; pfam00472 46234003288 ribosomal protein L31; Validated; Region: rpl31; CHL00136 46234003289 ribosomal protein S9; Region: rps9; CHL00079 46234003290 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 46234003291 23S rRNA interface [nucleotide binding]; other site 46234003292 L3 interface [polypeptide binding]; other site 46234003293 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 46234003294 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 46234003295 dimerization interface 3.5A [polypeptide binding]; other site 46234003296 active site 46234003297 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 46234003298 RNA polymerase alpha subunit; Region: rpoA; CHL00013 46234003299 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 46234003300 alphaNTD - beta interaction site [polypeptide binding]; other site 46234003301 alphaNTD homodimer interface [polypeptide binding]; other site 46234003302 alphaNTD - beta' interaction site [polypeptide binding]; other site 46234003303 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 46234003304 30S ribosomal protein S11; Validated; Region: PRK05309 46234003305 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 46234003306 30S ribosomal protein S13; Region: bact_S13; TIGR03631 46234003307 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 46234003308 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 46234003309 rRNA binding site [nucleotide binding]; other site 46234003310 predicted 30S ribosome binding site; other site 46234003311 adenylate kinase; Provisional; Region: adk; PRK02496 46234003312 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 46234003313 AMP-binding site [chemical binding]; other site 46234003314 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 46234003315 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 46234003316 SecY translocase; Region: SecY; pfam00344 46234003317 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 46234003318 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 46234003319 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 46234003320 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 46234003321 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 46234003322 5S rRNA interface [nucleotide binding]; other site 46234003323 L27 interface [polypeptide binding]; other site 46234003324 23S rRNA interface [nucleotide binding]; other site 46234003325 L5 interface [polypeptide binding]; other site 46234003326 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 46234003327 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 46234003328 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 46234003329 ribosomal protein S8; Region: rps8; CHL00042 46234003330 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 46234003331 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 46234003332 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 46234003333 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 46234003334 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 46234003335 RNA binding site [nucleotide binding]; other site 46234003336 ribosomal protein L14; Region: rpl14; CHL00057 46234003337 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 46234003338 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 46234003339 23S rRNA interface [nucleotide binding]; other site 46234003340 putative translocon interaction site; other site 46234003341 signal recognition particle (SRP54) interaction site; other site 46234003342 L23 interface [polypeptide binding]; other site 46234003343 trigger factor interaction site; other site 46234003344 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 46234003345 23S rRNA interface [nucleotide binding]; other site 46234003346 5S rRNA interface [nucleotide binding]; other site 46234003347 putative antibiotic binding site [chemical binding]; other site 46234003348 L25 interface [polypeptide binding]; other site 46234003349 L27 interface [polypeptide binding]; other site 46234003350 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 46234003351 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 46234003352 G-X-X-G motif; other site 46234003353 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 46234003354 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 46234003355 putative translocon binding site; other site 46234003356 protein-rRNA interface [nucleotide binding]; other site 46234003357 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 46234003358 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 46234003359 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 46234003360 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 46234003361 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 46234003362 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 46234003363 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 46234003364 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 46234003365 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234003366 putative active site [active] 46234003367 AAA ATPase domain; Region: AAA_16; pfam13191 46234003368 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234003369 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 46234003370 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 46234003371 putative catalytic cysteine [active] 46234003372 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 46234003373 homopentamer interface [polypeptide binding]; other site 46234003374 active site 46234003375 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 46234003376 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 46234003377 DHH family; Region: DHH; pfam01368 46234003378 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 46234003380 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 46234003381 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 46234003382 active site 46234003383 NTP binding site [chemical binding]; other site 46234003384 metal binding triad [ion binding]; metal-binding site 46234003385 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 46234003386 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 46234003387 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234003388 putative active site [active] 46234003389 Predicted helicase [General function prediction only]; Region: COG4889 46234003390 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 46234003391 ABC1 family; Region: ABC1; cl17513 46234003392 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 46234003393 active site 46234003394 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 46234003395 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 46234003396 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 46234003397 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 46234003398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234003399 Soluble P-type ATPase [General function prediction only]; Region: COG4087 46234003400 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 46234003401 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 46234003402 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234003403 DNA binding site [nucleotide binding] 46234003404 substrate interaction site [chemical binding]; other site 46234003405 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234003406 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 46234003407 intersubunit interface [polypeptide binding]; other site 46234003408 active site 46234003409 catalytic residue [active] 46234003410 Recombination protein O N terminal; Region: RecO_N; pfam11967 46234003411 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 46234003412 Recombination protein O C terminal; Region: RecO_C; pfam02565 46234003413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234003414 H+ Antiporter protein; Region: 2A0121; TIGR00900 46234003415 putative substrate translocation pore; other site 46234003416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234003417 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234003418 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 46234003419 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 46234003420 Uncharacterized conserved protein [Function unknown]; Region: COG4301 46234003421 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 46234003422 active site 46234003423 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 46234003424 phosphoglyceromutase; Provisional; Region: PRK05434 46234003425 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 46234003426 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 46234003427 Predicted transcriptional regulator [Transcription]; Region: COG2944 46234003428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234003429 non-specific DNA binding site [nucleotide binding]; other site 46234003430 salt bridge; other site 46234003431 sequence-specific DNA binding site [nucleotide binding]; other site 46234003432 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 46234003433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 46234003434 molybdopterin cofactor binding site; other site 46234003435 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 46234003436 putative molybdopterin cofactor binding site; other site 46234003437 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 46234003438 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 46234003439 RNA binding site [nucleotide binding]; other site 46234003440 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 46234003441 RNA binding site [nucleotide binding]; other site 46234003442 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 46234003443 RNA binding site [nucleotide binding]; other site 46234003444 Dienelactone hydrolase family; Region: DLH; pfam01738 46234003445 Predicted transcriptional regulators [Transcription]; Region: COG1725 46234003446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 46234003447 DNA-binding site [nucleotide binding]; DNA binding site 46234003448 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 46234003449 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 46234003450 active site 46234003451 dimerization interface [polypeptide binding]; other site 46234003452 Staphylococcal nuclease homologues; Region: SNc; smart00318 46234003453 Catalytic site; other site 46234003454 Staphylococcal nuclease homologue; Region: SNase; pfam00565 46234003455 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 46234003456 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234003457 catalytic loop [active] 46234003458 iron binding site [ion binding]; other site 46234003459 Uncharacterized conserved protein [Function unknown]; Region: COG1432 46234003460 LabA_like proteins; Region: LabA; cd10911 46234003461 putative metal binding site [ion binding]; other site 46234003462 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 46234003463 S-layer homology domain; Region: SLH; pfam00395 46234003464 S-layer homology domain; Region: SLH; pfam00395 46234003465 S-layer homology domain; Region: SLH; pfam00395 46234003466 S-layer homology domain; Region: SLH; pfam00395 46234003467 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 46234003468 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 46234003469 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 46234003470 thiamine phosphate binding site [chemical binding]; other site 46234003471 active site 46234003472 pyrophosphate binding site [ion binding]; other site 46234003473 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 46234003474 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 46234003475 thiS-thiF/thiG interaction site; other site 46234003476 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 46234003477 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 46234003478 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 46234003479 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 46234003480 CbbX; Provisional; Region: cbbX; CHL00181 46234003481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234003482 Walker A motif; other site 46234003483 ATP binding site [chemical binding]; other site 46234003484 Walker B motif; other site 46234003485 arginine finger; other site 46234003486 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 46234003487 Protein export membrane protein; Region: SecD_SecF; cl14618 46234003488 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 46234003489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234003490 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234003491 Predicted membrane protein [Function unknown]; Region: COG4371 46234003492 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 46234003493 oligomerization interface [polypeptide binding]; other site 46234003494 active site 46234003495 metal binding site [ion binding]; metal-binding site 46234003496 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 46234003497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 46234003498 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 46234003499 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 46234003500 homodimer interface [polypeptide binding]; other site 46234003501 active site 46234003502 heterodimer interface [polypeptide binding]; other site 46234003503 catalytic residue [active] 46234003504 metal binding site [ion binding]; metal-binding site 46234003505 RbcX protein; Region: RcbX; pfam02341 46234003506 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 46234003507 multimerization interface [polypeptide binding]; other site 46234003508 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 46234003509 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 46234003510 putative active site [active] 46234003511 Calx-beta domain; Region: Calx-beta; cl02522 46234003512 Calx-beta domain; Region: Calx-beta; cl02522 46234003513 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 46234003514 PUCC protein; Region: PUCC; pfam03209 46234003515 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 46234003516 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 46234003517 putative multimerization interface [polypeptide binding]; other site 46234003518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234003519 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 46234003520 catalytic residue [active] 46234003521 YCII-related domain; Region: YCII; cl00999 46234003522 Uncharacterized conserved protein [Function unknown]; Region: COG3937 46234003523 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 46234003524 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 46234003525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234003526 putative ADP-binding pocket [chemical binding]; other site 46234003527 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 46234003528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234003529 dimer interface [polypeptide binding]; other site 46234003530 conserved gate region; other site 46234003531 putative PBP binding loops; other site 46234003532 ABC-ATPase subunit interface; other site 46234003533 AAA domain; Region: AAA_21; pfam13304 46234003534 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 46234003535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234003537 homodimer interface [polypeptide binding]; other site 46234003538 catalytic residue [active] 46234003539 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 46234003540 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234003541 catalytic residues [active] 46234003542 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 46234003543 4Fe-4S binding domain; Region: Fer4; pfam00037 46234003544 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 46234003545 Uncharacterized conserved protein [Function unknown]; Region: COG5607 46234003546 Protein of unknown function (DUF483); Region: DUF483; cl17805 46234003547 Methyltransferase domain; Region: Methyltransf_25; pfam13649 46234003548 S-adenosylmethionine binding site [chemical binding]; other site 46234003549 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 46234003550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234003551 FeS/SAM binding site; other site 46234003552 KilA-N domain; Region: KilA-N; pfam04383 46234003553 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 46234003554 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 46234003555 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 46234003556 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 46234003557 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 46234003558 active site 46234003559 Zn binding site [ion binding]; other site 46234003560 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 46234003561 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 46234003562 active site 46234003563 dimer interface [polypeptide binding]; other site 46234003564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234003565 active site 46234003566 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 46234003567 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 46234003568 putative active site [active] 46234003569 catalytic site [active] 46234003570 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 46234003571 putative active site [active] 46234003572 catalytic site [active] 46234003573 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 46234003574 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 46234003575 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 46234003576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234003577 catalytic residue [active] 46234003578 Predicted membrane protein [Function unknown]; Region: COG1950 46234003579 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 46234003580 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234003581 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234003582 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 46234003583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234003584 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 46234003585 hypothetical protein; Provisional; Region: PRK04194 46234003586 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 46234003587 DNA adenine methylase (dam); Region: dam; TIGR00571 46234003588 Protein of unknown function (DUF751); Region: DUF751; pfam05421 46234003589 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 46234003590 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 46234003591 PetN; Region: PetN; cl15376 46234003592 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 46234003593 active site 46234003594 catalytic site [active] 46234003595 substrate binding site [chemical binding]; other site 46234003596 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 46234003597 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 46234003598 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 46234003599 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234003600 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 46234003601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234003602 motif II; other site 46234003603 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 46234003604 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 46234003605 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 46234003606 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 46234003607 Ligand binding site; other site 46234003608 Putative Catalytic site; other site 46234003609 DXD motif; other site 46234003610 Predicted membrane protein [Function unknown]; Region: COG2246 46234003611 GtrA-like protein; Region: GtrA; pfam04138 46234003612 FO synthase subunit 2; Reviewed; Region: PRK07360 46234003613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234003614 FeS/SAM binding site; other site 46234003615 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 46234003616 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 46234003617 NifU-like domain; Region: NifU; pfam01106 46234003618 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 46234003619 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 46234003620 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 46234003621 putative active site [active] 46234003622 catalytic site [active] 46234003623 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 46234003624 dimer interface [polypeptide binding]; other site 46234003625 active site 46234003626 aspartate-rich active site metal binding site; other site 46234003627 allosteric magnesium binding site [ion binding]; other site 46234003628 Schiff base residues; other site 46234003629 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 46234003630 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 46234003631 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 46234003632 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 46234003633 homodecamer interface [polypeptide binding]; other site 46234003634 GTP cyclohydrolase I; Provisional; Region: PLN03044 46234003635 active site 46234003636 putative catalytic site residues [active] 46234003637 zinc binding site [ion binding]; other site 46234003638 GTP-CH-I/GFRP interaction surface; other site 46234003639 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 46234003640 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 46234003641 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 46234003642 active site 46234003643 metal binding site [ion binding]; metal-binding site 46234003644 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 46234003645 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 46234003646 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 46234003647 anti sigma factor interaction site; other site 46234003648 regulatory phosphorylation site [posttranslational modification]; other site 46234003649 Thf1-like protein; Reviewed; Region: PRK13266 46234003650 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 46234003651 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 46234003652 nickel binding site [ion binding]; other site 46234003653 SET domain; Region: SET; pfam00856 46234003654 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 46234003655 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 46234003656 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 46234003657 active site 46234003658 catalytic residues [active] 46234003659 DNA binding site [nucleotide binding] 46234003660 Int/Topo IB signature motif; other site 46234003661 Leucine rich repeat variant; Region: LRV; pfam01816 46234003662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 46234003663 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 46234003664 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234003665 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234003666 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 46234003667 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 46234003668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234003669 RNA binding surface [nucleotide binding]; other site 46234003670 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 46234003671 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 46234003672 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 46234003673 GTP binding site; other site 46234003674 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 46234003675 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 46234003676 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 46234003677 Predicted helicase [General function prediction only]; Region: COG4889 46234003678 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 46234003679 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 46234003680 dimer interface [polypeptide binding]; other site 46234003681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234003682 catalytic residue [active] 46234003683 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 46234003684 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 46234003685 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 46234003686 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 46234003687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234003688 S-adenosylmethionine binding site [chemical binding]; other site 46234003689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234003690 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 46234003691 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 46234003692 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 46234003693 dimerization interface [polypeptide binding]; other site 46234003694 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 46234003695 ATP binding site [chemical binding]; other site 46234003696 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 46234003697 active site 1 [active] 46234003698 dimer interface [polypeptide binding]; other site 46234003699 hexamer interface [polypeptide binding]; other site 46234003700 active site 2 [active] 46234003701 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 46234003702 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 46234003703 HupF/HypC family; Region: HupF_HypC; pfam01455 46234003704 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 46234003705 Acylphosphatase; Region: Acylphosphatase; pfam00708 46234003706 HypF finger; Region: zf-HYPF; pfam07503 46234003707 HypF finger; Region: zf-HYPF; pfam07503 46234003708 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 46234003709 XisH protein; Region: XisH; pfam08814 46234003710 XisI protein; Region: XisI; pfam08869 46234003711 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234003712 active site 46234003713 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 46234003714 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 46234003715 putative catalytic residues [active] 46234003716 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 46234003717 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 46234003718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234003719 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 46234003720 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 46234003721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234003722 FAD dependent oxidoreductase; Region: DAO; pfam01266 46234003723 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 46234003724 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003725 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 46234003726 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 46234003728 Recombinase; Region: Recombinase; pfam07508 46234003729 adenylate kinase; Provisional; Region: adk; PRK02496 46234003730 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 46234003731 AMP-binding site [chemical binding]; other site 46234003732 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 46234003733 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234003734 catalytic residues [active] 46234003735 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003736 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 46234003737 CP12 domain; Region: CP12; cl14670 46234003738 FOG: CBS domain [General function prediction only]; Region: COG0517 46234003739 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 46234003740 CP12 domain; Region: CP12; pfam02672 46234003741 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 46234003742 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 46234003743 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 46234003744 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 46234003745 Fasciclin domain; Region: Fasciclin; pfam02469 46234003746 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 46234003747 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 46234003748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234003749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234003750 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234003751 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003752 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003753 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234003754 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 46234003755 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 46234003756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234003757 sequence-specific DNA binding site [nucleotide binding]; other site 46234003758 salt bridge; other site 46234003759 Domain of unknown function (DUF955); Region: DUF955; pfam06114 46234003760 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 46234003761 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 46234003762 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 46234003763 active site 46234003764 catalytic triad [active] 46234003765 oxyanion hole [active] 46234003766 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 46234003767 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 46234003768 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 46234003769 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234003770 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003771 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 46234003772 protein binding site [polypeptide binding]; other site 46234003773 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 46234003774 putative homodimer interface [polypeptide binding]; other site 46234003775 putative homotetramer interface [polypeptide binding]; other site 46234003776 putative metal binding site [ion binding]; other site 46234003777 putative homodimer-homodimer interface [polypeptide binding]; other site 46234003778 putative allosteric switch controlling residues; other site 46234003779 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 46234003780 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 46234003781 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 46234003782 nucleophilic elbow; other site 46234003783 nucleophilic elbow; other site 46234003784 catalytic triad; other site 46234003785 catalytic triad; other site 46234003786 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 46234003787 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 46234003788 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 46234003789 RNA methyltransferase, RsmE family; Region: TIGR00046 46234003790 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 46234003791 TPR repeat; Region: TPR_11; pfam13414 46234003792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003793 binding surface 46234003794 TPR motif; other site 46234003795 TPR repeat; Region: TPR_11; pfam13414 46234003796 TPR repeat; Region: TPR_11; pfam13414 46234003797 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234003798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234003799 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 46234003800 active site 46234003801 S2 subsite; other site 46234003802 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 46234003803 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 46234003804 active site 46234003805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 46234003806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 46234003807 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 46234003808 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 46234003809 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234003810 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234003811 acyl-activating enzyme (AAE) consensus motif; other site 46234003812 AMP binding site [chemical binding]; other site 46234003813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234003814 Condensation domain; Region: Condensation; pfam00668 46234003815 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234003816 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234003817 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234003818 acyl-activating enzyme (AAE) consensus motif; other site 46234003819 AMP binding site [chemical binding]; other site 46234003820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234003821 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234003822 H+ Antiporter protein; Region: 2A0121; TIGR00900 46234003823 Predicted membrane protein [Function unknown]; Region: COG4709 46234003824 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 46234003825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234003826 catalytic loop [active] 46234003827 iron binding site [ion binding]; other site 46234003828 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 46234003829 Stage II sporulation protein; Region: SpoIID; pfam08486 46234003830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234003831 non-specific DNA binding site [nucleotide binding]; other site 46234003832 salt bridge; other site 46234003833 sequence-specific DNA binding site [nucleotide binding]; other site 46234003834 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 46234003835 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 46234003836 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 46234003837 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 46234003838 anti sigma factor interaction site; other site 46234003839 regulatory phosphorylation site [posttranslational modification]; other site 46234003840 Response regulator receiver domain; Region: Response_reg; pfam00072 46234003841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234003842 active site 46234003843 phosphorylation site [posttranslational modification] 46234003844 intermolecular recognition site; other site 46234003845 dimerization interface [polypeptide binding]; other site 46234003846 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 46234003847 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 46234003848 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 46234003849 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 46234003850 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 46234003851 substrate binding site [chemical binding]; other site 46234003852 glutamase interaction surface [polypeptide binding]; other site 46234003853 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 46234003854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234003855 Walker A motif; other site 46234003856 ATP binding site [chemical binding]; other site 46234003857 Walker B motif; other site 46234003858 arginine finger; other site 46234003859 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 46234003860 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003861 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234003862 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234003863 TPR repeat; Region: TPR_11; pfam13414 46234003864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003865 binding surface 46234003866 TPR motif; other site 46234003867 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234003868 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234003869 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003870 active site 46234003871 ATP binding site [chemical binding]; other site 46234003872 substrate binding site [chemical binding]; other site 46234003873 activation loop (A-loop); other site 46234003874 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 46234003875 anti sigma factor interaction site; other site 46234003876 regulatory phosphorylation site [posttranslational modification]; other site 46234003877 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 46234003878 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 46234003879 argininosuccinate synthase; Provisional; Region: PRK13820 46234003880 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 46234003881 ANP binding site [chemical binding]; other site 46234003882 Substrate Binding Site II [chemical binding]; other site 46234003883 Substrate Binding Site I [chemical binding]; other site 46234003884 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234003885 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 46234003886 Probable Catalytic site; other site 46234003887 metal-binding site 46234003888 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 46234003889 dimer interface [polypeptide binding]; other site 46234003890 motif 1; other site 46234003891 active site 46234003892 motif 2; other site 46234003893 motif 3; other site 46234003894 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 46234003895 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 46234003896 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 46234003897 Competence protein; Region: Competence; pfam03772 46234003898 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 46234003899 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 46234003900 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 46234003901 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 46234003902 active site 46234003903 TDP-binding site; other site 46234003904 acceptor substrate-binding pocket; other site 46234003905 homodimer interface [polypeptide binding]; other site 46234003906 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 46234003907 Cytochrome P450; Region: p450; pfam00067 46234003908 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 46234003909 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 46234003910 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 46234003911 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 46234003912 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234003913 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 46234003914 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234003915 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234003916 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234003917 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003918 active site 46234003919 ATP binding site [chemical binding]; other site 46234003920 substrate binding site [chemical binding]; other site 46234003921 activation loop (A-loop); other site 46234003922 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234003923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003924 active site 46234003925 ATP binding site [chemical binding]; other site 46234003926 substrate binding site [chemical binding]; other site 46234003927 activation loop (A-loop); other site 46234003928 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 46234003929 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 46234003930 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 46234003931 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234003932 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 46234003933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 46234003934 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 46234003935 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 46234003936 GTPase Era; Reviewed; Region: era; PRK00089 46234003937 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 46234003938 G1 box; other site 46234003939 GTP/Mg2+ binding site [chemical binding]; other site 46234003940 Switch I region; other site 46234003941 G2 box; other site 46234003942 Switch II region; other site 46234003943 G3 box; other site 46234003944 G4 box; other site 46234003945 G5 box; other site 46234003946 KH domain; Region: KH_2; pfam07650 46234003947 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 46234003948 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 46234003949 folate binding site [chemical binding]; other site 46234003950 NADP+ binding site [chemical binding]; other site 46234003951 TPR repeat; Region: TPR_11; pfam13414 46234003952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003953 binding surface 46234003954 TPR motif; other site 46234003955 TPR repeat; Region: TPR_11; pfam13414 46234003956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234003957 binding surface 46234003958 TPR motif; other site 46234003959 hypothetical protein; Provisional; Region: PRK02724 46234003960 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 46234003961 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234003962 active site 46234003963 substrate binding site [chemical binding]; other site 46234003964 ATP binding site [chemical binding]; other site 46234003965 activation loop (A-loop); other site 46234003966 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234003967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234003968 structural tetrad; other site 46234003969 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 46234003970 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 46234003971 active site 46234003972 catalytic site [active] 46234003973 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 46234003974 calcium/proton exchanger (cax); Region: cax; TIGR00378 46234003975 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 46234003976 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234003977 methionine aminopeptidase; Provisional; Region: PRK12318 46234003978 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 46234003979 active site 46234003980 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 46234003981 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234003982 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234003983 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234003984 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234003985 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234003986 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234003987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234003988 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 46234003989 active site 46234003990 metal binding site [ion binding]; metal-binding site 46234003991 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 46234003992 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 46234003993 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 46234003994 trimer interface [polypeptide binding]; other site 46234003995 putative metal binding site [ion binding]; other site 46234003996 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 46234003997 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 46234003998 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234003999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 46234004000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 46234004001 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 46234004002 Cell division protein FtsA; Region: FtsA; cl17206 46234004003 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 46234004004 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 46234004005 AMIN domain; Region: AMIN; pfam11741 46234004006 Secretin and TonB N terminus short domain; Region: STN; pfam07660 46234004007 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 46234004008 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 46234004009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234004010 active site 46234004011 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 46234004012 Predicted transcriptional regulator [Transcription]; Region: COG1959 46234004013 Transcriptional regulator; Region: Rrf2; cl17282 46234004014 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 46234004015 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 46234004016 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 46234004017 Cl- selectivity filter; other site 46234004018 Cl- binding residues [ion binding]; other site 46234004019 pore gating glutamate residue; other site 46234004020 dimer interface [polypeptide binding]; other site 46234004021 FOG: CBS domain [General function prediction only]; Region: COG0517 46234004022 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 46234004023 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 46234004024 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 46234004025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234004026 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 46234004027 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 46234004028 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 46234004029 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 46234004030 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 46234004031 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 46234004032 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 46234004033 tartrate dehydrogenase; Region: TTC; TIGR02089 46234004034 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 46234004035 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 46234004036 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 46234004037 Protein of unknown function (DUF1308); Region: DUF1308; pfam07000 46234004038 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 46234004039 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 46234004040 metal binding site [ion binding]; metal-binding site 46234004041 dimer interface [polypeptide binding]; other site 46234004042 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 46234004043 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 46234004044 Walker A/P-loop; other site 46234004045 ATP binding site [chemical binding]; other site 46234004046 Q-loop/lid; other site 46234004047 ABC transporter signature motif; other site 46234004048 Walker B; other site 46234004049 D-loop; other site 46234004050 H-loop/switch region; other site 46234004051 5-oxoprolinase; Region: PLN02666 46234004052 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 46234004053 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 46234004054 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 46234004055 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 46234004056 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 46234004057 dimer interface [polypeptide binding]; other site 46234004058 putative functional site; other site 46234004059 putative MPT binding site; other site 46234004060 FtsH Extracellular; Region: FtsH_ext; pfam06480 46234004061 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 46234004062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234004063 Walker A motif; other site 46234004064 ATP binding site [chemical binding]; other site 46234004065 Walker B motif; other site 46234004066 arginine finger; other site 46234004067 Peptidase family M41; Region: Peptidase_M41; pfam01434 46234004068 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 46234004069 propionate/acetate kinase; Provisional; Region: PRK12379 46234004070 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 46234004071 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 46234004072 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 46234004073 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 46234004074 Surface antigen; Region: Bac_surface_Ag; pfam01103 46234004075 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234004076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234004077 TPR motif; other site 46234004078 binding surface 46234004079 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 46234004081 TIR domain; Region: TIR_2; pfam13676 46234004082 TIR domain; Region: TIR_2; pfam13676 46234004083 TIR domain; Region: TIR_2; pfam13676 46234004084 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 46234004085 CHASE2 domain; Region: CHASE2; pfam05226 46234004086 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 46234004087 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 46234004088 DEAD-like helicases superfamily; Region: DEXDc; smart00487 46234004089 ATP binding site [chemical binding]; other site 46234004090 Mg++ binding site [ion binding]; other site 46234004091 motif III; other site 46234004092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234004093 nucleotide binding region [chemical binding]; other site 46234004094 ATP-binding site [chemical binding]; other site 46234004095 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234004096 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 46234004097 DNA polymerase III subunit beta; Validated; Region: PRK05643 46234004098 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 46234004099 putative DNA binding surface [nucleotide binding]; other site 46234004100 dimer interface [polypeptide binding]; other site 46234004101 beta-clamp/clamp loader binding surface; other site 46234004102 beta-clamp/translesion DNA polymerase binding surface; other site 46234004103 cytochrome c-550; Provisional; Region: psbV; PRK13618 46234004104 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 46234004105 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 46234004106 putative acyl-acceptor binding pocket; other site 46234004107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234004108 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234004109 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 46234004110 putative NAD(P) binding site [chemical binding]; other site 46234004111 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234004112 HSP70 interaction site [polypeptide binding]; other site 46234004113 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234004114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004116 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004117 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 46234004118 DNA polymerase III subunit delta'; Validated; Region: PRK07399 46234004119 AAA ATPase domain; Region: AAA_16; pfam13191 46234004120 DNA polymerase III subunit delta'; Validated; Region: PRK08485 46234004121 thymidylate kinase; Validated; Region: tmk; PRK00698 46234004122 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 46234004123 TMP-binding site; other site 46234004124 ATP-binding site [chemical binding]; other site 46234004125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 46234004126 nudix motif; other site 46234004127 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 46234004128 Domain of unknown function DUF20; Region: UPF0118; pfam01594 46234004129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234004130 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234004131 Probable transposase; Region: OrfB_IS605; pfam01385 46234004132 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234004133 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 46234004134 active site 46234004135 NAD binding site [chemical binding]; other site 46234004136 metal binding site [ion binding]; metal-binding site 46234004137 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 46234004138 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 46234004139 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 46234004140 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 46234004141 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 46234004142 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 46234004143 TrkA-N domain; Region: TrkA_N; pfam02254 46234004144 TrkA-C domain; Region: TrkA_C; pfam02080 46234004145 Sm and related proteins; Region: Sm_like; cl00259 46234004146 heptamer interface [polypeptide binding]; other site 46234004147 Sm1 motif; other site 46234004148 hexamer interface [polypeptide binding]; other site 46234004149 RNA binding site [nucleotide binding]; other site 46234004150 Sm2 motif; other site 46234004151 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 46234004152 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 46234004153 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 46234004154 CHAT domain; Region: CHAT; pfam12770 46234004155 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 46234004156 Nitrogen regulatory protein P-II; Region: P-II; smart00938 46234004157 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 46234004158 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 46234004159 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 46234004160 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 46234004161 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 46234004162 protein binding site [polypeptide binding]; other site 46234004163 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 46234004164 Catalytic dyad [active] 46234004165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 46234004166 septum formation inhibitor; Reviewed; Region: minC; PRK00513 46234004167 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 46234004168 septum site-determining protein MinD; Region: minD_bact; TIGR01968 46234004169 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 46234004170 Switch I; other site 46234004171 Switch II; other site 46234004172 cell division topological specificity factor MinE; Provisional; Region: PRK13988 46234004173 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 46234004174 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 46234004175 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234004176 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004177 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234004178 Tetratricopeptide repeat; Region: TPR_10; pfam13374 46234004179 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234004181 binding surface 46234004182 TPR motif; other site 46234004183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234004184 AAA ATPase domain; Region: AAA_16; pfam13191 46234004185 NB-ARC domain; Region: NB-ARC; pfam00931 46234004186 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 46234004187 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 46234004188 16S/18S rRNA binding site [nucleotide binding]; other site 46234004189 S13e-L30e interaction site [polypeptide binding]; other site 46234004190 25S rRNA binding site [nucleotide binding]; other site 46234004191 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 46234004192 Stage II sporulation protein; Region: SpoIID; pfam08486 46234004193 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 46234004194 Chain length determinant protein; Region: Wzz; cl15801 46234004195 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 46234004196 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234004197 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 46234004198 nitrilase; Region: PLN02798 46234004199 putative active site [active] 46234004200 catalytic triad [active] 46234004201 dimer interface [polypeptide binding]; other site 46234004202 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 46234004203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234004204 motif II; other site 46234004205 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 46234004206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 46234004207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234004208 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 46234004209 active site 46234004210 catalytic triad [active] 46234004211 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 46234004212 Predicted permeases [General function prediction only]; Region: COG0795 46234004213 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 46234004214 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 46234004215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 46234004216 putative acyl-acceptor binding pocket; other site 46234004217 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 46234004218 GSH binding site [chemical binding]; other site 46234004219 catalytic residues [active] 46234004220 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 46234004221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234004222 substrate binding pocket [chemical binding]; other site 46234004223 membrane-bound complex binding site; other site 46234004224 hinge residues; other site 46234004225 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 46234004226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004227 dimer interface [polypeptide binding]; other site 46234004228 conserved gate region; other site 46234004229 putative PBP binding loops; other site 46234004230 ABC-ATPase subunit interface; other site 46234004231 Restriction endonuclease; Region: Mrr_cat; pfam04471 46234004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004233 dimer interface [polypeptide binding]; other site 46234004234 conserved gate region; other site 46234004235 putative PBP binding loops; other site 46234004236 ABC-ATPase subunit interface; other site 46234004237 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 46234004238 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 46234004239 Walker A/P-loop; other site 46234004240 ATP binding site [chemical binding]; other site 46234004241 Q-loop/lid; other site 46234004242 ABC transporter signature motif; other site 46234004243 Walker B; other site 46234004244 D-loop; other site 46234004245 H-loop/switch region; other site 46234004246 Uncharacterized conserved protein [Function unknown]; Region: COG1479 46234004247 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234004248 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234004249 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 46234004250 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234004251 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 46234004252 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234004253 structural tetrad; other site 46234004254 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 46234004255 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 46234004256 P-loop, Walker A motif; other site 46234004257 Base recognition motif; other site 46234004258 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 46234004259 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 46234004260 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 46234004261 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 46234004262 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 46234004263 Walker A/P-loop; other site 46234004264 ATP binding site [chemical binding]; other site 46234004265 Q-loop/lid; other site 46234004266 ABC transporter signature motif; other site 46234004267 Walker B; other site 46234004268 D-loop; other site 46234004269 H-loop/switch region; other site 46234004270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004271 dimer interface [polypeptide binding]; other site 46234004272 ABC-ATPase subunit interface; other site 46234004273 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 46234004274 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 46234004275 active site 46234004276 NTP binding site [chemical binding]; other site 46234004277 metal binding triad [ion binding]; metal-binding site 46234004278 antibiotic binding site [chemical binding]; other site 46234004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 46234004280 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 46234004281 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 46234004282 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 46234004283 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 46234004284 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 46234004285 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234004286 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 46234004287 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234004288 GAF domain; Region: GAF; pfam01590 46234004289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234004290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234004291 dimer interface [polypeptide binding]; other site 46234004292 phosphorylation site [posttranslational modification] 46234004293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234004294 ATP binding site [chemical binding]; other site 46234004295 Mg2+ binding site [ion binding]; other site 46234004296 G-X-G motif; other site 46234004297 PsaD; Region: PsaD; pfam02531 46234004298 anthranilate synthase component I; Provisional; Region: PRK13565 46234004299 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 46234004300 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 46234004301 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 46234004302 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 46234004303 CoA-binding site [chemical binding]; other site 46234004304 ATP-binding [chemical binding]; other site 46234004305 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 46234004306 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 46234004307 active site 46234004308 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 46234004309 active site 46234004310 SAM binding site [chemical binding]; other site 46234004311 homodimer interface [polypeptide binding]; other site 46234004312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234004313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234004314 active site 46234004315 phosphorylation site [posttranslational modification] 46234004316 intermolecular recognition site; other site 46234004317 dimerization interface [polypeptide binding]; other site 46234004318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234004319 DNA binding residues [nucleotide binding] 46234004320 dimerization interface [polypeptide binding]; other site 46234004321 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 46234004322 Double zinc ribbon; Region: DZR; pfam12773 46234004323 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 46234004324 active site 46234004325 Protein phosphatase 2C; Region: PP2C; pfam00481 46234004326 CHAT domain; Region: CHAT; cl17868 46234004327 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234004328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234004329 phosphopeptide binding site; other site 46234004330 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234004331 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234004332 phosphopeptide binding site; other site 46234004333 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 46234004334 Predicted membrane protein [Function unknown]; Region: COG3431 46234004335 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 46234004336 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 46234004337 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 46234004338 B12 binding site [chemical binding]; other site 46234004339 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 46234004340 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 46234004341 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 46234004342 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 46234004343 active site 46234004344 HIGH motif; other site 46234004345 dimer interface [polypeptide binding]; other site 46234004346 KMSKS motif; other site 46234004347 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 46234004348 FAD binding site [chemical binding]; other site 46234004349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234004350 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234004351 active site 46234004352 ATP binding site [chemical binding]; other site 46234004353 substrate binding site [chemical binding]; other site 46234004354 activation loop (A-loop); other site 46234004355 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 46234004356 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 46234004357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 46234004358 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 46234004359 NAD(P) binding site [chemical binding]; other site 46234004360 homotetramer interface [polypeptide binding]; other site 46234004361 homodimer interface [polypeptide binding]; other site 46234004362 active site 46234004363 Calx-beta domain; Region: Calx-beta; cl02522 46234004364 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004365 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004366 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004367 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 46234004368 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 46234004369 Mg++ binding site [ion binding]; other site 46234004370 putative catalytic motif [active] 46234004371 substrate binding site [chemical binding]; other site 46234004372 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 46234004373 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 46234004374 ring oligomerisation interface [polypeptide binding]; other site 46234004375 ATP/Mg binding site [chemical binding]; other site 46234004376 stacking interactions; other site 46234004377 hinge regions; other site 46234004378 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 46234004379 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 46234004380 cobalamin binding residues [chemical binding]; other site 46234004381 putative BtuC binding residues; other site 46234004382 dimer interface [polypeptide binding]; other site 46234004383 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 46234004384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234004385 acyl-activating enzyme (AAE) consensus motif; other site 46234004386 active site 46234004387 AMP binding site [chemical binding]; other site 46234004388 CoA binding site [chemical binding]; other site 46234004389 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 46234004390 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 46234004391 NAD(P) binding site [chemical binding]; other site 46234004392 catalytic residues [active] 46234004393 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 46234004394 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 46234004395 dimer interface [polypeptide binding]; other site 46234004396 motif 1; other site 46234004397 active site 46234004398 motif 2; other site 46234004399 motif 3; other site 46234004400 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 46234004401 anticodon binding site; other site 46234004402 SnoaL-like domain; Region: SnoaL_2; pfam12680 46234004403 Uncharacterized conserved protein [Function unknown]; Region: COG1742 46234004404 aspartate kinase; Provisional; Region: PRK07431 46234004405 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 46234004406 putative nucleotide binding site [chemical binding]; other site 46234004407 putative catalytic residues [active] 46234004408 putative Mg ion binding site [ion binding]; other site 46234004409 putative aspartate binding site [chemical binding]; other site 46234004410 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 46234004411 putative allosteric regulatory site; other site 46234004412 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 46234004413 putative allosteric regulatory residue; other site 46234004414 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 46234004415 putative allosteric regulatory site; other site 46234004416 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 46234004417 PBP superfamily domain; Region: PBP_like_2; cl17296 46234004418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 46234004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004420 dimer interface [polypeptide binding]; other site 46234004421 conserved gate region; other site 46234004422 putative PBP binding loops; other site 46234004423 ABC-ATPase subunit interface; other site 46234004424 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 46234004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004426 dimer interface [polypeptide binding]; other site 46234004427 conserved gate region; other site 46234004428 putative PBP binding loops; other site 46234004429 ABC-ATPase subunit interface; other site 46234004430 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 46234004431 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 46234004432 Walker A/P-loop; other site 46234004433 ATP binding site [chemical binding]; other site 46234004434 Q-loop/lid; other site 46234004435 ABC transporter signature motif; other site 46234004436 Walker B; other site 46234004437 D-loop; other site 46234004438 H-loop/switch region; other site 46234004439 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 46234004440 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234004441 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234004442 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 46234004443 PBP superfamily domain; Region: PBP_like_2; cl17296 46234004444 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 46234004445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004446 dimer interface [polypeptide binding]; other site 46234004447 conserved gate region; other site 46234004448 putative PBP binding loops; other site 46234004449 ABC-ATPase subunit interface; other site 46234004450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 46234004451 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 46234004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234004453 dimer interface [polypeptide binding]; other site 46234004454 conserved gate region; other site 46234004455 putative PBP binding loops; other site 46234004456 ABC-ATPase subunit interface; other site 46234004457 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 46234004458 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 46234004459 Walker A/P-loop; other site 46234004460 ATP binding site [chemical binding]; other site 46234004461 Q-loop/lid; other site 46234004462 ABC transporter signature motif; other site 46234004463 Walker B; other site 46234004464 D-loop; other site 46234004465 H-loop/switch region; other site 46234004466 Uncharacterized conserved protein [Function unknown]; Region: COG2968 46234004467 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 46234004468 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 46234004469 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 46234004470 dimer interface [polypeptide binding]; other site 46234004471 ssDNA binding site [nucleotide binding]; other site 46234004472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 46234004473 rod shape-determining protein MreB; Provisional; Region: PRK13927 46234004474 MreB and similar proteins; Region: MreB_like; cd10225 46234004475 nucleotide binding site [chemical binding]; other site 46234004476 Mg binding site [ion binding]; other site 46234004477 putative protofilament interaction site [polypeptide binding]; other site 46234004478 RodZ interaction site [polypeptide binding]; other site 46234004479 rod shape-determining protein MreC; Provisional; Region: PRK13922 46234004480 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 46234004481 rod shape-determining protein MreC; Region: MreC; pfam04085 46234004482 Uncharacterized conserved protein [Function unknown]; Region: COG1432 46234004483 LabA_like proteins; Region: LabA; cd10911 46234004484 putative metal binding site [ion binding]; other site 46234004485 2-isopropylmalate synthase; Validated; Region: PRK00915 46234004486 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 46234004487 active site 46234004488 catalytic residues [active] 46234004489 metal binding site [ion binding]; metal-binding site 46234004490 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 46234004491 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234004492 AccI restriction endonuclease; Region: RE_AccI; pfam09545 46234004493 AccI restriction endonuclease; Region: RE_AccI; pfam09545 46234004494 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 46234004495 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 46234004496 Substrate binding site; other site 46234004497 Mg++ binding site; other site 46234004498 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 46234004499 active site 46234004500 substrate binding site [chemical binding]; other site 46234004501 CoA binding site [chemical binding]; other site 46234004502 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 46234004503 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234004504 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234004505 structural tetrad; other site 46234004506 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234004507 structural tetrad; other site 46234004508 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234004509 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234004510 structural tetrad; other site 46234004511 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 46234004512 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 46234004513 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 46234004514 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 46234004515 active site residue [active] 46234004516 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 46234004517 active site residue [active] 46234004518 glutathione reductase; Validated; Region: PRK06116 46234004519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 46234004520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234004521 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 46234004522 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234004523 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 46234004524 cofactor binding site; other site 46234004525 DNA binding site [nucleotide binding] 46234004526 substrate interaction site [chemical binding]; other site 46234004527 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 46234004528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234004530 homodimer interface [polypeptide binding]; other site 46234004531 catalytic residue [active] 46234004532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 46234004533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234004534 Coenzyme A binding pocket [chemical binding]; other site 46234004535 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 46234004536 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234004537 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 46234004538 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 46234004539 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 46234004540 classical (c) SDRs; Region: SDR_c; cd05233 46234004541 short chain dehydrogenase; Provisional; Region: PRK07041 46234004542 NAD(P) binding site [chemical binding]; other site 46234004543 active site 46234004544 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234004545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234004546 S-adenosylmethionine binding site [chemical binding]; other site 46234004547 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 46234004548 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004549 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 46234004550 acyl-activating enzyme (AAE) consensus motif; other site 46234004551 AMP binding site [chemical binding]; other site 46234004552 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004553 hydroxyglutarate oxidase; Provisional; Region: PRK11728 46234004554 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 46234004555 Condensation domain; Region: Condensation; pfam00668 46234004556 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234004557 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004558 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004559 acyl-activating enzyme (AAE) consensus motif; other site 46234004560 AMP binding site [chemical binding]; other site 46234004561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004562 Condensation domain; Region: Condensation; pfam00668 46234004563 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234004564 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004565 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004566 acyl-activating enzyme (AAE) consensus motif; other site 46234004567 AMP binding site [chemical binding]; other site 46234004568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004569 Condensation domain; Region: Condensation; pfam00668 46234004570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234004571 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004572 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004573 acyl-activating enzyme (AAE) consensus motif; other site 46234004574 AMP binding site [chemical binding]; other site 46234004575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234004576 S-adenosylmethionine binding site [chemical binding]; other site 46234004577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234004578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004579 Condensation domain; Region: Condensation; pfam00668 46234004580 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234004581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004583 acyl-activating enzyme (AAE) consensus motif; other site 46234004584 AMP binding site [chemical binding]; other site 46234004585 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234004587 S-adenosylmethionine binding site [chemical binding]; other site 46234004588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234004589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004590 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 46234004591 putative active site [active] 46234004592 putative substrate binding site [chemical binding]; other site 46234004593 putative cosubstrate binding site; other site 46234004594 catalytic site [active] 46234004595 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 46234004596 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004597 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234004598 acyl-activating enzyme (AAE) consensus motif; other site 46234004599 AMP binding site [chemical binding]; other site 46234004600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004601 Condensation domain; Region: Condensation; pfam00668 46234004602 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234004603 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234004604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234004605 acyl-activating enzyme (AAE) consensus motif; other site 46234004606 AMP binding site [chemical binding]; other site 46234004607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234004608 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 46234004609 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 46234004610 arginine-tRNA ligase; Region: PLN02286 46234004611 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 46234004612 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 46234004613 active site 46234004614 HIGH motif; other site 46234004615 KMSK motif region; other site 46234004616 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 46234004617 tRNA binding surface [nucleotide binding]; other site 46234004618 anticodon binding site; other site 46234004619 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 46234004620 MutS domain III; Region: MutS_III; pfam05192 46234004621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234004622 Walker A/P-loop; other site 46234004623 ATP binding site [chemical binding]; other site 46234004624 Q-loop/lid; other site 46234004625 ABC transporter signature motif; other site 46234004626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234004627 D-loop; other site 46234004628 H-loop/switch region; other site 46234004629 Smr domain; Region: Smr; pfam01713 46234004630 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 46234004631 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 46234004632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234004633 active site 46234004634 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234004635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234004636 active site 46234004637 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 46234004638 dimer interface [polypeptide binding]; other site 46234004639 catalytic triad [active] 46234004640 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 46234004641 EamA-like transporter family; Region: EamA; pfam00892 46234004642 EamA-like transporter family; Region: EamA; pfam00892 46234004643 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 46234004644 MoaE homodimer interface [polypeptide binding]; other site 46234004645 MoaD interaction [polypeptide binding]; other site 46234004646 active site residues [active] 46234004647 Uncharacterized conserved protein [Function unknown]; Region: COG3339 46234004648 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 46234004649 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 46234004650 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 46234004651 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 46234004652 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 46234004653 putative NAD(P) binding site [chemical binding]; other site 46234004654 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 46234004655 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 46234004656 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 46234004657 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 46234004658 putative active site [active] 46234004659 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 46234004660 Caspase domain; Region: Peptidase_C14; pfam00656 46234004661 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 46234004662 ATP-sulfurylase; Region: ATPS; cd00517 46234004663 active site 46234004664 HXXH motif; other site 46234004665 flexible loop; other site 46234004666 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234004667 Cadherin repeat-like domain; Region: CA_like; cl15786 46234004668 Ca2+ binding site [ion binding]; other site 46234004669 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 46234004670 active site 46234004671 catalytic triad [active] 46234004672 oxyanion hole [active] 46234004673 Cadherin repeat-like domain; Region: CA_like; cl15786 46234004674 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234004675 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004676 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004677 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234004678 Calx-beta domain; Region: Calx-beta; pfam03160 46234004679 Family description; Region: VCBS; pfam13517 46234004680 Family description; Region: VCBS; pfam13517 46234004681 Family description; Region: VCBS; pfam13517 46234004682 PA14 domain; Region: PA14; cl08459 46234004683 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 46234004684 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 46234004685 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234004686 YcfA-like protein; Region: YcfA; pfam07927 46234004687 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 46234004688 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 46234004689 putative active site [active] 46234004690 catalytic site [active] 46234004691 putative metal binding site [ion binding]; other site 46234004692 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 46234004693 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 46234004694 putative active site [active] 46234004695 catalytic site [active] 46234004696 putative metal binding site [ion binding]; other site 46234004697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 46234004698 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234004699 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 46234004700 HNH endonuclease; Region: HNH_2; pfam13391 46234004701 DNA repair protein RadA; Provisional; Region: PRK11823 46234004702 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 46234004703 Walker A motif/ATP binding site; other site 46234004704 ATP binding site [chemical binding]; other site 46234004705 Walker B motif; other site 46234004706 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 46234004707 Ycf27; Reviewed; Region: orf27; CHL00148 46234004708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234004709 active site 46234004710 phosphorylation site [posttranslational modification] 46234004711 intermolecular recognition site; other site 46234004712 dimerization interface [polypeptide binding]; other site 46234004713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234004714 DNA binding site [nucleotide binding] 46234004715 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 46234004716 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 46234004717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234004718 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 46234004719 Cytochrome P450; Region: p450; pfam00067 46234004720 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 46234004721 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 46234004722 TPP-binding site [chemical binding]; other site 46234004723 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 46234004724 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234004725 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004728 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004729 Abi-like protein; Region: Abi_2; pfam07751 46234004730 PemK-like protein; Region: PemK; pfam02452 46234004731 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 46234004732 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 46234004733 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 46234004734 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 46234004735 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234004736 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234004737 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234004738 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234004739 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 46234004740 PemK-like protein; Region: PemK; pfam02452 46234004741 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234004742 oligomeric interface; other site 46234004743 putative active site [active] 46234004744 homodimer interface [polypeptide binding]; other site 46234004745 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234004746 putative active site [active] 46234004747 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 46234004748 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 46234004749 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 46234004750 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 46234004751 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 46234004752 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234004753 DRTGG domain; Region: DRTGG; pfam07085 46234004754 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 46234004755 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004756 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 46234004757 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004758 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 46234004759 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004760 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 46234004761 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004762 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 46234004763 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234004764 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 46234004765 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 46234004766 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 46234004767 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 46234004768 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 46234004769 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234004770 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 46234004771 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 46234004772 DXD motif; other site 46234004773 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 46234004774 CoA binding domain; Region: CoA_binding_2; pfam13380 46234004775 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 46234004776 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 46234004777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 46234004778 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 46234004779 nickel binding site [ion binding]; other site 46234004780 classical (c) SDRs; Region: SDR_c; cd05233 46234004781 active site 46234004782 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234004783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234004786 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 46234004787 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 46234004788 FOG: CBS domain [General function prediction only]; Region: COG0517 46234004789 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 46234004790 CP12 domain; Region: CP12; pfam02672 46234004791 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 46234004792 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 46234004793 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234004794 catalytic loop [active] 46234004795 iron binding site [ion binding]; other site 46234004796 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 46234004797 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 46234004798 dimer interface [polypeptide binding]; other site 46234004799 [2Fe-2S] cluster binding site [ion binding]; other site 46234004800 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 46234004801 SLBB domain; Region: SLBB; pfam10531 46234004802 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 46234004803 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 46234004804 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 46234004805 putative dimer interface [polypeptide binding]; other site 46234004806 [2Fe-2S] cluster binding site [ion binding]; other site 46234004807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 46234004808 Ligand Binding Site [chemical binding]; other site 46234004809 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 46234004810 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 46234004811 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 46234004812 Ligand Binding Site [chemical binding]; other site 46234004813 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 46234004814 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 46234004815 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234004816 Soluble P-type ATPase [General function prediction only]; Region: COG4087 46234004817 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 46234004818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234004819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234004820 ATP binding site [chemical binding]; other site 46234004821 Mg2+ binding site [ion binding]; other site 46234004822 G-X-G motif; other site 46234004823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234004824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234004825 active site 46234004826 phosphorylation site [posttranslational modification] 46234004827 intermolecular recognition site; other site 46234004828 dimerization interface [polypeptide binding]; other site 46234004829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234004830 DNA binding residues [nucleotide binding] 46234004831 dimerization interface [polypeptide binding]; other site 46234004832 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234004833 oligomeric interface; other site 46234004834 homodimer interface [polypeptide binding]; other site 46234004835 putative active site [active] 46234004836 Uncharacterized conserved protein [Function unknown]; Region: COG4279 46234004837 SWIM zinc finger; Region: SWIM; pfam04434 46234004838 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 46234004839 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234004840 SNF2 Helicase protein; Region: DUF3670; pfam12419 46234004841 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 46234004842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234004843 ATP binding site [chemical binding]; other site 46234004844 putative Mg++ binding site [ion binding]; other site 46234004845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234004846 nucleotide binding region [chemical binding]; other site 46234004847 ATP-binding site [chemical binding]; other site 46234004848 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234004849 putative active site [active] 46234004850 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 46234004851 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 46234004852 RNase E interface [polypeptide binding]; other site 46234004853 trimer interface [polypeptide binding]; other site 46234004854 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 46234004855 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 46234004856 RNase E interface [polypeptide binding]; other site 46234004857 trimer interface [polypeptide binding]; other site 46234004858 active site 46234004859 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 46234004860 putative nucleic acid binding region [nucleotide binding]; other site 46234004861 G-X-X-G motif; other site 46234004862 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 46234004863 RNA binding site [nucleotide binding]; other site 46234004864 domain interface; other site 46234004865 argininosuccinate lyase; Provisional; Region: PRK00855 46234004866 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 46234004867 active sites [active] 46234004868 tetramer interface [polypeptide binding]; other site 46234004869 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 46234004870 AIR carboxylase; Region: AIRC; smart01001 46234004871 Mechanosensitive ion channel; Region: MS_channel; pfam00924 46234004872 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 46234004873 Mechanosensitive ion channel; Region: MS_channel; pfam00924 46234004874 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 46234004875 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 46234004876 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 46234004877 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 46234004878 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234004879 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 46234004880 homotrimer interaction site [polypeptide binding]; other site 46234004881 zinc binding site [ion binding]; other site 46234004882 CDP-binding sites; other site 46234004883 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 46234004884 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 46234004885 proposed catalytic triad [active] 46234004886 active site nucleophile [active] 46234004887 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 46234004888 ATP-grasp domain; Region: ATP-grasp_4; cl17255 46234004889 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234004890 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234004891 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 46234004892 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234004893 P loop; other site 46234004894 Nucleotide binding site [chemical binding]; other site 46234004895 DTAP/Switch II; other site 46234004896 Switch I; other site 46234004897 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 46234004898 UbiA prenyltransferase family; Region: UbiA; pfam01040 46234004899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234004900 binding surface 46234004901 TPR motif; other site 46234004902 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 46234004903 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 46234004904 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 46234004905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234004906 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 46234004907 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 46234004908 putative hydrophobic ligand binding site [chemical binding]; other site 46234004909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 46234004910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 46234004911 active site 46234004912 catalytic tetrad [active] 46234004913 Response regulator receiver domain; Region: Response_reg; pfam00072 46234004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234004915 active site 46234004916 phosphorylation site [posttranslational modification] 46234004917 intermolecular recognition site; other site 46234004918 dimerization interface [polypeptide binding]; other site 46234004919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234004920 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234004921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 46234004922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 46234004923 metal binding site [ion binding]; metal-binding site 46234004924 active site 46234004925 I-site; other site 46234004926 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 46234004927 putative binding surface; other site 46234004928 active site 46234004929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234004930 active site 46234004931 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 46234004932 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 46234004933 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 46234004934 beta-phosphoglucomutase; Region: bPGM; TIGR01990 46234004935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234004936 sucrose synthase; Region: sucr_synth; TIGR02470 46234004937 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 46234004938 putative ADP-binding pocket [chemical binding]; other site 46234004939 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 46234004940 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 46234004941 dimer interface [polypeptide binding]; other site 46234004942 PYR/PP interface [polypeptide binding]; other site 46234004943 TPP binding site [chemical binding]; other site 46234004944 substrate binding site [chemical binding]; other site 46234004945 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 46234004946 Domain of unknown function; Region: EKR; smart00890 46234004947 4Fe-4S binding domain; Region: Fer4_6; pfam12837 46234004948 4Fe-4S binding domain; Region: Fer4; pfam00037 46234004949 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 46234004950 TPP-binding site [chemical binding]; other site 46234004951 dimer interface [polypeptide binding]; other site 46234004952 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 46234004953 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 46234004954 putative active site [active] 46234004955 putative FMN binding site [chemical binding]; other site 46234004956 putative substrate binding site [chemical binding]; other site 46234004957 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 46234004958 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 46234004959 active site 46234004960 ADP/pyrophosphate binding site [chemical binding]; other site 46234004961 dimerization interface [polypeptide binding]; other site 46234004962 allosteric effector site; other site 46234004963 fructose-1,6-bisphosphate binding site; other site 46234004964 FOG: CBS domain [General function prediction only]; Region: COG0517 46234004965 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 46234004966 PAS fold; Region: PAS; pfam00989 46234004967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234004968 putative active site [active] 46234004969 heme pocket [chemical binding]; other site 46234004970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234004971 PAS fold; Region: PAS_3; pfam08447 46234004972 putative active site [active] 46234004973 heme pocket [chemical binding]; other site 46234004974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234004975 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 46234004976 putative active site [active] 46234004977 heme pocket [chemical binding]; other site 46234004978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234004979 dimer interface [polypeptide binding]; other site 46234004980 phosphorylation site [posttranslational modification] 46234004981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234004982 ATP binding site [chemical binding]; other site 46234004983 Mg2+ binding site [ion binding]; other site 46234004984 G-X-G motif; other site 46234004985 Response regulator receiver domain; Region: Response_reg; pfam00072 46234004986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234004987 active site 46234004988 phosphorylation site [posttranslational modification] 46234004989 intermolecular recognition site; other site 46234004990 dimerization interface [polypeptide binding]; other site 46234004991 pyruvate kinase; Validated; Region: PRK08187 46234004992 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 46234004993 domain interfaces; other site 46234004994 active site 46234004995 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 46234004996 phosphoenolpyruvate synthase; Validated; Region: PRK06464 46234004997 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 46234004998 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 46234004999 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 46234005000 isoleucyl-tRNA synthetase; Region: PLN02843 46234005001 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 46234005002 HIGH motif; other site 46234005003 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 46234005004 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 46234005005 active site 46234005006 KMSKS motif; other site 46234005007 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 46234005008 tRNA binding surface [nucleotide binding]; other site 46234005009 anticodon binding site; other site 46234005010 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 46234005011 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 46234005012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234005013 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 46234005014 active site 46234005015 catalytic residues [active] 46234005016 DNA binding site [nucleotide binding] 46234005017 Int/Topo IB signature motif; other site 46234005018 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 46234005019 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 46234005020 Protein of unknown function, DUF608; Region: DUF608; pfam04685 46234005021 Homeodomain-like domain; Region: HTH_23; pfam13384 46234005022 Winged helix-turn helix; Region: HTH_29; pfam13551 46234005023 Homeodomain-like domain; Region: HTH_32; pfam13565 46234005024 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 46234005025 ligand binding site [chemical binding]; other site 46234005026 flexible hinge region; other site 46234005027 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234005028 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 46234005029 putative active site [active] 46234005030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234005031 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 46234005032 Walker A/P-loop; other site 46234005033 ATP binding site [chemical binding]; other site 46234005034 Q-loop/lid; other site 46234005035 ABC transporter signature motif; other site 46234005036 Walker B; other site 46234005037 D-loop; other site 46234005038 H-loop/switch region; other site 46234005039 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234005040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234005041 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234005042 hypothetical protein; Provisional; Region: PRK09256 46234005043 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 46234005044 excinuclease ABC subunit B; Provisional; Region: PRK05298 46234005045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234005046 ATP binding site [chemical binding]; other site 46234005047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234005048 nucleotide binding region [chemical binding]; other site 46234005049 ATP-binding site [chemical binding]; other site 46234005050 Ultra-violet resistance protein B; Region: UvrB; pfam12344 46234005051 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005052 putative active site [active] 46234005053 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 46234005054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005055 Walker A/P-loop; other site 46234005056 ATP binding site [chemical binding]; other site 46234005057 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005058 putative active site [active] 46234005059 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 46234005060 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 46234005061 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234005062 active site 46234005063 DGQHR domain; Region: DGQHR; TIGR03187 46234005064 DNA-sulfur modification-associated; Region: DndB; cl17621 46234005065 hypothetical protein; Provisional; Region: PRK06850 46234005066 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 46234005067 Active Sites [active] 46234005068 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 46234005069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005070 Walker A/P-loop; other site 46234005071 ATP binding site [chemical binding]; other site 46234005072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005073 ABC transporter signature motif; other site 46234005074 Walker B; other site 46234005075 D-loop; other site 46234005076 H-loop/switch region; other site 46234005077 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 46234005078 AmpG-like permease; Region: 2A0125; TIGR00901 46234005079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234005080 Probable transposase; Region: OrfB_IS605; pfam01385 46234005081 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234005082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234005083 Coenzyme A binding pocket [chemical binding]; other site 46234005084 HEAT repeats; Region: HEAT_2; pfam13646 46234005085 HEAT repeats; Region: HEAT_2; pfam13646 46234005086 HEAT repeats; Region: HEAT_2; pfam13646 46234005087 Cache domain; Region: Cache_1; pfam02743 46234005088 HAMP domain; Region: HAMP; pfam00672 46234005089 dimerization interface [polypeptide binding]; other site 46234005090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234005091 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 46234005092 putative active site [active] 46234005093 heme pocket [chemical binding]; other site 46234005094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234005095 putative active site [active] 46234005096 heme pocket [chemical binding]; other site 46234005097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234005098 PAS fold; Region: PAS_3; pfam08447 46234005099 putative active site [active] 46234005100 heme pocket [chemical binding]; other site 46234005101 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 46234005102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 46234005103 metal binding site [ion binding]; metal-binding site 46234005104 active site 46234005105 I-site; other site 46234005106 Response regulator receiver domain; Region: Response_reg; pfam00072 46234005107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234005108 active site 46234005109 phosphorylation site [posttranslational modification] 46234005110 intermolecular recognition site; other site 46234005111 dimerization interface [polypeptide binding]; other site 46234005112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 46234005113 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 46234005114 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 46234005115 Protein of unknown function (DUF512); Region: DUF512; pfam04459 46234005116 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 46234005117 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 46234005118 ABC1 family; Region: ABC1; cl17513 46234005119 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 46234005120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 46234005121 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 46234005122 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 46234005123 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005124 putative active site [active] 46234005125 hydrolase, alpha/beta fold family protein; Region: PLN02824 46234005126 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234005127 S-layer homology domain; Region: SLH; pfam00395 46234005128 S-layer homology domain; Region: SLH; pfam00395 46234005129 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 46234005130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234005131 motif II; other site 46234005132 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234005133 structural tetrad; other site 46234005134 PQQ-like domain; Region: PQQ_2; pfam13360 46234005135 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 46234005136 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 46234005137 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 46234005138 P-loop; other site 46234005139 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 46234005140 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 46234005141 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 46234005142 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 46234005143 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 46234005144 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 46234005145 DEAD-like helicases superfamily; Region: DEXDc; smart00487 46234005146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234005147 ATP binding site [chemical binding]; other site 46234005148 putative Mg++ binding site [ion binding]; other site 46234005149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234005150 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 46234005151 nucleotide binding region [chemical binding]; other site 46234005152 ATP-binding site [chemical binding]; other site 46234005153 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 46234005154 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 46234005155 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 46234005156 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 46234005157 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 46234005158 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 46234005159 ATP-binding site [chemical binding]; other site 46234005160 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 46234005161 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 46234005162 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 46234005163 active site 46234005164 Substrate binding site; other site 46234005165 Mg++ binding site; other site 46234005166 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 46234005167 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 46234005168 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 46234005169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234005170 Probable transposase; Region: OrfB_IS605; pfam01385 46234005171 YciI-like protein; Reviewed; Region: PRK12864 46234005172 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 46234005173 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 46234005174 putative tRNA-binding site [nucleotide binding]; other site 46234005175 B3/4 domain; Region: B3_4; pfam03483 46234005176 tRNA synthetase B5 domain; Region: B5; smart00874 46234005177 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 46234005178 dimer interface [polypeptide binding]; other site 46234005179 motif 1; other site 46234005180 motif 3; other site 46234005181 motif 2; other site 46234005182 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 46234005183 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005184 putative active site [active] 46234005185 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234005186 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234005187 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234005188 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234005189 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005190 putative active site [active] 46234005191 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 46234005192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234005193 Walker A motif; other site 46234005194 ATP binding site [chemical binding]; other site 46234005195 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 46234005196 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234005197 AAA ATPase domain; Region: AAA_16; pfam13191 46234005198 WD domain, G-beta repeat; Region: WD40; pfam00400 46234005199 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234005200 structural tetrad; other site 46234005201 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234005202 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234005203 structural tetrad; other site 46234005204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234005205 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234005206 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 46234005207 Walker A/P-loop; other site 46234005208 ATP binding site [chemical binding]; other site 46234005209 Q-loop/lid; other site 46234005210 ABC transporter signature motif; other site 46234005211 Walker B; other site 46234005212 D-loop; other site 46234005213 H-loop/switch region; other site 46234005214 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 46234005215 RNA/DNA hybrid binding site [nucleotide binding]; other site 46234005216 active site 46234005217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234005218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 46234005219 Coenzyme A binding pocket [chemical binding]; other site 46234005220 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 46234005221 Ligand Binding Site [chemical binding]; other site 46234005222 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 46234005223 Ligand Binding Site [chemical binding]; other site 46234005224 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 46234005225 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 46234005226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234005227 catalytic loop [active] 46234005228 iron binding site [ion binding]; other site 46234005229 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 46234005230 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 46234005231 cobalamin synthase; Reviewed; Region: cobS; PRK00235 46234005232 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 46234005233 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 46234005234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234005235 active site 46234005236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234005237 Coenzyme A binding pocket [chemical binding]; other site 46234005238 AAA domain; Region: AAA_21; pfam13304 46234005239 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 46234005240 protein I interface; other site 46234005241 D2 interface; other site 46234005242 protein T interface; other site 46234005243 chlorophyll binding site; other site 46234005244 beta carotene binding site; other site 46234005245 pheophytin binding site; other site 46234005246 manganese-stabilizing polypeptide interface; other site 46234005247 CP43 interface; other site 46234005248 protein L interface; other site 46234005249 oxygen evolving complex binding site; other site 46234005250 bromide binding site; other site 46234005251 quinone binding site; other site 46234005252 Fe binding site [ion binding]; other site 46234005253 core light harvesting interface; other site 46234005254 cytochrome b559 alpha subunit interface; other site 46234005255 cytochrome c-550 interface; other site 46234005256 protein J interface; other site 46234005257 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 46234005258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234005259 FeS/SAM binding site; other site 46234005260 MAPEG family; Region: MAPEG; cl09190 46234005261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 46234005262 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 46234005263 TPR repeat; Region: TPR_11; pfam13414 46234005264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234005265 binding surface 46234005266 TPR motif; other site 46234005267 TPR repeat; Region: TPR_11; pfam13414 46234005268 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 46234005269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 46234005270 D-xylulose kinase; Region: XylB; TIGR01312 46234005271 nucleotide binding site [chemical binding]; other site 46234005272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234005273 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234005274 phosphopeptide binding site; other site 46234005275 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234005276 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234005277 active site 46234005278 ATP binding site [chemical binding]; other site 46234005279 substrate binding site [chemical binding]; other site 46234005280 activation loop (A-loop); other site 46234005281 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234005282 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234005283 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234005284 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 46234005285 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 46234005286 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234005287 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234005288 active site 46234005289 ATP binding site [chemical binding]; other site 46234005290 substrate binding site [chemical binding]; other site 46234005291 activation loop (A-loop); other site 46234005292 GUN4-like; Region: GUN4; pfam05419 46234005293 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 46234005294 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 46234005295 23S rRNA binding site [nucleotide binding]; other site 46234005296 L21 binding site [polypeptide binding]; other site 46234005297 L13 binding site [polypeptide binding]; other site 46234005298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234005299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 46234005300 substrate binding pocket [chemical binding]; other site 46234005301 membrane-bound complex binding site; other site 46234005302 hinge residues; other site 46234005303 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234005304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234005305 binding surface 46234005306 TPR motif; other site 46234005307 TPR repeat; Region: TPR_11; pfam13414 46234005308 tyramine oxidase; Provisional; Region: tynA; PRK11504 46234005309 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 46234005310 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 46234005311 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 46234005312 geranylgeranyl reductase; Region: ChlP; TIGR02028 46234005313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 46234005314 hypothetical protein; Provisional; Region: PRK07236 46234005315 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 46234005316 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 46234005317 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234005318 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005319 putative active site [active] 46234005320 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234005321 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 46234005322 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 46234005323 active site 46234005324 HIGH motif; other site 46234005325 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 46234005326 KMSKS motif; other site 46234005327 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 46234005328 tRNA binding surface [nucleotide binding]; other site 46234005329 anticodon binding site; other site 46234005330 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 46234005331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234005332 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 46234005333 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 46234005334 active site 46234005335 metal binding site [ion binding]; metal-binding site 46234005336 interdomain interaction site; other site 46234005337 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 46234005338 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 46234005339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234005340 Coenzyme A binding pocket [chemical binding]; other site 46234005341 WD40 repeats; Region: WD40; smart00320 46234005342 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234005343 structural tetrad; other site 46234005344 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234005345 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234005346 structural tetrad; other site 46234005347 TIR domain; Region: TIR_2; pfam13676 46234005348 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234005349 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234005350 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 46234005351 ParA-like protein; Provisional; Region: PHA02518 46234005352 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234005353 P-loop; other site 46234005354 Magnesium ion binding site [ion binding]; other site 46234005355 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 46234005356 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 46234005357 DNA binding residues [nucleotide binding] 46234005358 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 46234005359 catalytic residues [active] 46234005360 catalytic nucleophile [active] 46234005361 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 46234005362 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 46234005363 GatB domain; Region: GatB_Yqey; smart00845 46234005364 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 46234005365 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 46234005366 Abortive infection C-terminus; Region: Abi_C; pfam14355 46234005367 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 46234005368 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 46234005369 HIGH motif; other site 46234005370 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 46234005371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 46234005372 active site 46234005373 KMSKS motif; other site 46234005374 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 46234005375 tRNA binding surface [nucleotide binding]; other site 46234005376 Caspase domain; Region: Peptidase_C14; pfam00656 46234005377 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234005378 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234005379 proton extrusion protein PcxA; Provisional; Region: PRK02507 46234005380 proteasome-activating nucleotidase; Provisional; Region: PRK03992 46234005381 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 46234005382 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234005383 P loop; other site 46234005384 Nucleotide binding site [chemical binding]; other site 46234005385 DTAP/Switch II; other site 46234005386 Switch I; other site 46234005387 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234005388 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 46234005389 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 46234005390 G1 box; other site 46234005391 GTP/Mg2+ binding site [chemical binding]; other site 46234005392 G2 box; other site 46234005393 Switch I region; other site 46234005394 G3 box; other site 46234005395 Switch II region; other site 46234005396 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 46234005397 Uncharacterized conserved protein [Function unknown]; Region: COG2947 46234005398 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 46234005399 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 46234005400 substrate binding site [chemical binding]; other site 46234005401 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 46234005402 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 46234005403 substrate binding site [chemical binding]; other site 46234005404 ligand binding site [chemical binding]; other site 46234005405 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 46234005406 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 46234005407 dimer interface [polypeptide binding]; other site 46234005408 anticodon binding site; other site 46234005409 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 46234005410 homodimer interface [polypeptide binding]; other site 46234005411 motif 1; other site 46234005412 active site 46234005413 motif 2; other site 46234005414 GAD domain; Region: GAD; pfam02938 46234005415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 46234005416 active site 46234005417 motif 3; other site 46234005418 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234005419 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005420 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005421 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234005422 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005423 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 46234005424 DctM-like transporters; Region: DctM; pfam06808 46234005425 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 46234005426 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005427 putative active site [active] 46234005428 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 46234005429 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 46234005430 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234005431 Putative addiction module component; Region: Unstab_antitox; cl09921 46234005432 PIN domain; Region: PIN_3; cl17397 46234005433 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 46234005434 Sulfatase; Region: Sulfatase; pfam00884 46234005435 Domain of unknown function (DUF202); Region: DUF202; cl09954 46234005436 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 46234005437 bile acid transporter; Region: bass; TIGR00841 46234005438 Predicted GTPase [General function prediction only]; Region: COG3596 46234005439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005440 YfjP GTPase; Region: YfjP; cd11383 46234005441 G1 box; other site 46234005442 Walker A/P-loop; other site 46234005443 GTP/Mg2+ binding site [chemical binding]; other site 46234005444 ATP binding site [chemical binding]; other site 46234005445 Switch I region; other site 46234005446 G2 box; other site 46234005447 Switch II region; other site 46234005448 G3 box; other site 46234005449 G4 box; other site 46234005450 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 46234005451 heme binding pocket [chemical binding]; other site 46234005452 heme ligand [chemical binding]; other site 46234005453 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 46234005454 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 46234005455 active site 46234005456 substrate binding site [chemical binding]; other site 46234005457 metal binding site [ion binding]; metal-binding site 46234005458 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 46234005459 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 46234005460 dimer interface [polypeptide binding]; other site 46234005461 decamer (pentamer of dimers) interface [polypeptide binding]; other site 46234005462 catalytic triad [active] 46234005463 AAA domain; Region: AAA_21; pfam13304 46234005464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005465 Walker B; other site 46234005466 D-loop; other site 46234005467 H-loop/switch region; other site 46234005468 Protein of unknown function DUF104; Region: DUF104; pfam01954 46234005469 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 46234005470 Amidinotransferase; Region: Amidinotransf; cl12043 46234005471 Uncharacterized conserved protein [Function unknown]; Region: COG1915 46234005472 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 46234005473 homodimer interface [polypeptide binding]; other site 46234005474 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 46234005475 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234005476 active site 46234005477 ATP binding site [chemical binding]; other site 46234005478 substrate binding site [chemical binding]; other site 46234005479 activation loop (A-loop); other site 46234005480 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234005481 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234005482 Putative restriction endonuclease; Region: Uma2; pfam05685 46234005483 putative active site [active] 46234005484 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234005485 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234005486 active site 46234005487 metal binding site [ion binding]; metal-binding site 46234005488 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 46234005489 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234005490 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234005491 magnesium chelatase subunit H; Provisional; Region: PLN03241 46234005492 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 46234005493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234005494 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 46234005495 FtsX-like permease family; Region: FtsX; pfam02687 46234005496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 46234005497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234005498 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234005499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234005500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005501 Walker A/P-loop; other site 46234005502 ATP binding site [chemical binding]; other site 46234005503 Q-loop/lid; other site 46234005504 ABC transporter signature motif; other site 46234005505 Walker B; other site 46234005506 D-loop; other site 46234005507 H-loop/switch region; other site 46234005508 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 46234005509 molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355 46234005510 ATP binding site [chemical binding]; other site 46234005511 substrate interface [chemical binding]; other site 46234005512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234005513 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234005514 Probable transposase; Region: OrfB_IS605; pfam01385 46234005515 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234005516 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 46234005517 YcaO-like family; Region: YcaO; pfam02624 46234005518 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 46234005519 putative FMN binding site [chemical binding]; other site 46234005520 NADPH bind site [chemical binding]; other site 46234005521 S-layer homology domain; Region: SLH; pfam00395 46234005522 S-layer homology domain; Region: SLH; pfam00395 46234005523 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 46234005524 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 46234005525 active site 46234005526 8-oxo-dGMP binding site [chemical binding]; other site 46234005527 nudix motif; other site 46234005528 metal binding site [ion binding]; metal-binding site 46234005529 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 46234005530 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 46234005531 putative sugar binding sites [chemical binding]; other site 46234005532 Q-X-W motif; other site 46234005533 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234005534 AAA ATPase domain; Region: AAA_16; pfam13191 46234005535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234005536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234005537 TPR motif; other site 46234005538 binding surface 46234005539 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234005540 FOG: CBS domain [General function prediction only]; Region: COG0517 46234005541 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 46234005542 HEAT repeats; Region: HEAT_2; pfam13646 46234005543 HEAT repeats; Region: HEAT_2; pfam13646 46234005544 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 46234005545 triosephosphate isomerase; Provisional; Region: PRK14565 46234005546 substrate binding site [chemical binding]; other site 46234005547 dimer interface [polypeptide binding]; other site 46234005548 catalytic triad [active] 46234005549 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 46234005550 dihydropteroate synthase; Region: DHPS; TIGR01496 46234005551 substrate binding pocket [chemical binding]; other site 46234005552 dimer interface [polypeptide binding]; other site 46234005553 inhibitor binding site; inhibition site 46234005554 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 46234005555 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 46234005556 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 46234005557 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 46234005558 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 46234005559 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 46234005560 Walker A/P-loop; other site 46234005561 ATP binding site [chemical binding]; other site 46234005562 Q-loop/lid; other site 46234005563 ABC transporter signature motif; other site 46234005564 Walker B; other site 46234005565 D-loop; other site 46234005566 H-loop/switch region; other site 46234005567 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 46234005568 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 46234005569 putative active site pocket [active] 46234005570 4-fold oligomerization interface [polypeptide binding]; other site 46234005571 metal binding residues [ion binding]; metal-binding site 46234005572 3-fold/trimer interface [polypeptide binding]; other site 46234005573 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 46234005574 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 46234005575 NAD binding site [chemical binding]; other site 46234005576 homotetramer interface [polypeptide binding]; other site 46234005577 homodimer interface [polypeptide binding]; other site 46234005578 substrate binding site [chemical binding]; other site 46234005579 active site 46234005580 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 46234005581 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 46234005582 ligand binding site [chemical binding]; other site 46234005583 flexible hinge region; other site 46234005584 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 46234005585 putative switch regulator; other site 46234005586 non-specific DNA interactions [nucleotide binding]; other site 46234005587 DNA binding site [nucleotide binding] 46234005588 sequence specific DNA binding site [nucleotide binding]; other site 46234005589 putative cAMP binding site [chemical binding]; other site 46234005590 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 46234005591 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 46234005592 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 46234005593 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 46234005594 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 46234005595 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 46234005596 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234005597 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234005598 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 46234005599 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 46234005600 Peptidase family U32; Region: Peptidase_U32; pfam01136 46234005601 Collagenase; Region: DUF3656; pfam12392 46234005602 Peptidase family U32; Region: Peptidase_U32; cl03113 46234005603 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 46234005604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 46234005605 G1 box; other site 46234005606 GTP/Mg2+ binding site [chemical binding]; other site 46234005607 G2 box; other site 46234005608 Switch I region; other site 46234005609 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 46234005610 G3 box; other site 46234005611 Switch II region; other site 46234005612 G4 box; other site 46234005613 KGK domain; Region: KGK; pfam08872 46234005614 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234005615 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234005616 active site 46234005617 Bacterial SH3 domain; Region: SH3_3; pfam08239 46234005618 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234005619 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234005620 active site 46234005621 metal binding site [ion binding]; metal-binding site 46234005622 CTP synthetase; Validated; Region: pyrG; PRK05380 46234005623 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 46234005624 Catalytic site [active] 46234005625 active site 46234005626 UTP binding site [chemical binding]; other site 46234005627 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 46234005628 active site 46234005629 putative oxyanion hole; other site 46234005630 catalytic triad [active] 46234005631 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 46234005632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 46234005633 nucleotide binding site [chemical binding]; other site 46234005634 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 46234005635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234005636 dimer interface [polypeptide binding]; other site 46234005637 conserved gate region; other site 46234005638 ABC-ATPase subunit interface; other site 46234005639 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 46234005640 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 46234005641 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234005642 Methyltransferase domain; Region: Methyltransf_24; pfam13578 46234005643 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234005644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234005645 Putative restriction endonuclease; Region: Uma2; pfam05685 46234005646 putative active site [active] 46234005647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 46234005648 binding surface 46234005649 TPR motif; other site 46234005650 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 46234005651 Walker A/P-loop; other site 46234005652 ATP binding site [chemical binding]; other site 46234005653 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 46234005654 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 46234005655 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 46234005656 ABC transporter signature motif; other site 46234005657 Walker B; other site 46234005658 D-loop; other site 46234005659 H-loop/switch region; other site 46234005660 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234005661 oligomeric interface; other site 46234005662 putative active site [active] 46234005663 homodimer interface [polypeptide binding]; other site 46234005664 Predicted ATPase [General function prediction only]; Region: COG4637 46234005665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005666 Walker A/P-loop; other site 46234005667 ATP binding site [chemical binding]; other site 46234005668 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 46234005669 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234005670 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234005671 oligomeric interface; other site 46234005672 putative active site [active] 46234005673 homodimer interface [polypeptide binding]; other site 46234005674 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 46234005675 PRC-barrel domain; Region: PRC; pfam05239 46234005676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 46234005677 PRC-barrel domain; Region: PRC; pfam05239 46234005678 PRC-barrel domain; Region: PRC; pfam05239 46234005679 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 46234005680 Domain of unknown function DUF21; Region: DUF21; pfam01595 46234005681 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 46234005682 Transporter associated domain; Region: CorC_HlyC; smart01091 46234005683 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 46234005684 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 46234005685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234005686 ATP binding site [chemical binding]; other site 46234005687 putative Mg++ binding site [ion binding]; other site 46234005688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234005689 nucleotide binding region [chemical binding]; other site 46234005690 ATP-binding site [chemical binding]; other site 46234005691 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 46234005692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005693 AAA domain; Region: AAA_21; pfam13304 46234005694 Walker A/P-loop; other site 46234005695 ATP binding site [chemical binding]; other site 46234005696 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005697 putative active site [active] 46234005698 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 46234005699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234005700 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234005701 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 46234005702 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 46234005703 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 46234005704 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234005705 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 46234005706 Domain of unknown function DUF20; Region: UPF0118; pfam01594 46234005707 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 46234005708 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 46234005709 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 46234005710 active site 46234005711 Substrate binding site; other site 46234005712 Mg++ binding site; other site 46234005713 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 46234005714 putative trimer interface [polypeptide binding]; other site 46234005715 putative CoA binding site [chemical binding]; other site 46234005716 arginine decarboxylase; Provisional; Region: PRK05354 46234005717 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 46234005718 dimer interface [polypeptide binding]; other site 46234005719 active site 46234005720 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 46234005721 catalytic residues [active] 46234005722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 46234005723 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 46234005724 active site 46234005725 multimer interface [polypeptide binding]; other site 46234005726 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 46234005727 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 46234005728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234005730 active site 46234005731 phosphorylation site [posttranslational modification] 46234005732 intermolecular recognition site; other site 46234005733 dimerization interface [polypeptide binding]; other site 46234005734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234005735 DNA binding site [nucleotide binding] 46234005736 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 46234005737 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 46234005738 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 46234005739 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 46234005740 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 46234005741 Walker A/P-loop; other site 46234005742 ATP binding site [chemical binding]; other site 46234005743 Q-loop/lid; other site 46234005744 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 46234005745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005746 ABC transporter signature motif; other site 46234005747 Walker B; other site 46234005748 D-loop; other site 46234005749 H-loop/switch region; other site 46234005750 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234005751 AAA-like domain; Region: AAA_10; pfam12846 46234005752 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 46234005753 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234005754 oligomeric interface; other site 46234005755 putative active site [active] 46234005756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234005757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234005758 dimer interface [polypeptide binding]; other site 46234005759 phosphorylation site [posttranslational modification] 46234005760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234005761 ATP binding site [chemical binding]; other site 46234005762 Mg2+ binding site [ion binding]; other site 46234005763 G-X-G motif; other site 46234005764 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 46234005765 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 46234005766 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 46234005767 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234005768 putative active site [active] 46234005769 seryl-tRNA synthetase; Provisional; Region: PRK05431 46234005770 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 46234005771 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 46234005772 dimer interface [polypeptide binding]; other site 46234005773 active site 46234005774 motif 1; other site 46234005775 motif 2; other site 46234005776 motif 3; other site 46234005777 Nuclease-related domain; Region: NERD; pfam08378 46234005778 Part of AAA domain; Region: AAA_19; pfam13245 46234005779 Family description; Region: UvrD_C_2; pfam13538 46234005780 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 46234005781 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 46234005782 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 46234005783 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 46234005784 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 46234005785 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 46234005786 active site 46234005787 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 46234005788 protein binding site [polypeptide binding]; other site 46234005789 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 46234005790 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 46234005791 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 46234005792 minor groove reading motif; other site 46234005793 helix-hairpin-helix signature motif; other site 46234005794 substrate binding pocket [chemical binding]; other site 46234005795 active site 46234005796 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 46234005797 ribosomal protein S14; Region: rps14; CHL00074 46234005798 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 46234005799 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 46234005800 active site 46234005801 catalytic residues [active] 46234005802 metal binding site [ion binding]; metal-binding site 46234005803 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234005804 oligomeric interface; other site 46234005805 putative active site [active] 46234005806 homodimer interface [polypeptide binding]; other site 46234005807 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 46234005808 Predicted transcriptional regulator [Transcription]; Region: COG3682 46234005809 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 46234005810 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 46234005811 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 46234005812 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 46234005813 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 46234005814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234005815 dimer interface [polypeptide binding]; other site 46234005816 conserved gate region; other site 46234005817 putative PBP binding loops; other site 46234005818 ABC-ATPase subunit interface; other site 46234005819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005820 Walker A/P-loop; other site 46234005821 ATP binding site [chemical binding]; other site 46234005822 ABC transporter; Region: ABC_tran; pfam00005 46234005823 Q-loop/lid; other site 46234005824 ABC transporter signature motif; other site 46234005825 Walker B; other site 46234005826 D-loop; other site 46234005827 H-loop/switch region; other site 46234005828 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 46234005829 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 46234005830 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 46234005831 putative active site [active] 46234005832 Src Homology 3 domain superfamily; Region: SH3; cl17036 46234005833 peptide ligand binding site [polypeptide binding]; other site 46234005834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005835 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234005836 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005838 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234005839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005840 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 46234005841 putative hexamer interface [polypeptide binding]; other site 46234005842 putative hexagonal pore; other site 46234005843 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 46234005844 Hexamer interface [polypeptide binding]; other site 46234005845 Hexagonal pore residue; other site 46234005846 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 46234005847 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 46234005848 putative trimer interface [polypeptide binding]; other site 46234005849 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 46234005850 trimer interface [polypeptide binding]; other site 46234005851 active site 46234005852 substrate binding site [chemical binding]; other site 46234005853 putative CoA binding site [chemical binding]; other site 46234005854 CoA binding site [chemical binding]; other site 46234005855 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 46234005856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 46234005857 Flavodoxin; Region: Flavodoxin_1; pfam00258 46234005858 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 46234005859 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 46234005860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 46234005861 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 46234005862 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 46234005863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 46234005864 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 46234005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234005866 S-adenosylmethionine binding site [chemical binding]; other site 46234005867 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234005868 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234005869 active site 46234005870 ATP binding site [chemical binding]; other site 46234005871 substrate binding site [chemical binding]; other site 46234005872 activation loop (A-loop); other site 46234005873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234005874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234005875 active site 46234005876 ATP binding site [chemical binding]; other site 46234005877 substrate binding site [chemical binding]; other site 46234005878 activation loop (A-loop); other site 46234005879 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 46234005880 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 46234005881 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 46234005882 Family description; Region: UvrD_C_2; pfam13538 46234005883 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 46234005884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234005885 ATP binding site [chemical binding]; other site 46234005886 Mg2+ binding site [ion binding]; other site 46234005887 G-X-G motif; other site 46234005888 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 46234005889 ATP binding site [chemical binding]; other site 46234005890 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 46234005891 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 46234005892 active site residue [active] 46234005893 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 46234005894 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 46234005895 active site 46234005896 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234005897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234005898 S-adenosylmethionine synthetase; Validated; Region: PRK05250 46234005899 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 46234005900 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 46234005901 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 46234005902 CHAT domain; Region: CHAT; cl17868 46234005903 XisH protein; Region: XisH; pfam08814 46234005904 XisI protein; Region: XisI; pfam08869 46234005905 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 46234005906 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234005907 putative ligand binding site [chemical binding]; other site 46234005908 phosphoribulokinase; Provisional; Region: PRK07429 46234005909 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 46234005910 active site 46234005911 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 46234005912 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 46234005913 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 46234005914 dimerization interface [polypeptide binding]; other site 46234005915 FAD binding pocket [chemical binding]; other site 46234005916 FAD binding motif [chemical binding]; other site 46234005917 catalytic residues [active] 46234005918 NAD binding pocket [chemical binding]; other site 46234005919 phosphate binding motif [ion binding]; other site 46234005920 beta-alpha-beta structure motif; other site 46234005921 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 46234005922 homoserine dehydrogenase; Provisional; Region: PRK06349 46234005923 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 46234005924 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 46234005925 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 46234005926 LVIVD repeat; Region: LVIVD; pfam08309 46234005927 LVIVD repeat; Region: LVIVD; pfam08309 46234005928 LVIVD repeat; Region: LVIVD; pfam08309 46234005929 LVIVD repeat; Region: LVIVD; pfam08309 46234005930 LVIVD repeat; Region: LVIVD; pfam08309 46234005931 LVIVD repeat; Region: LVIVD; pfam08309 46234005932 LVIVD repeat; Region: LVIVD; pfam08309 46234005933 LVIVD repeat; Region: LVIVD; pfam08309 46234005934 LVIVD repeat; Region: LVIVD; pfam08309 46234005935 LVIVD repeat; Region: LVIVD; pfam08309 46234005936 LVIVD repeat; Region: LVIVD; pfam08309 46234005937 LVIVD repeat; Region: LVIVD; pfam08309 46234005938 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234005939 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234005940 Ca2+ binding site [ion binding]; other site 46234005941 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234005942 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 46234005943 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 46234005944 Part of AAA domain; Region: AAA_19; pfam13245 46234005945 Family description; Region: UvrD_C_2; pfam13538 46234005946 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 46234005947 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 46234005948 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 46234005949 Verru_Chthon cassette protein C; Region: TIGR02599 46234005950 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 46234005951 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 46234005952 Lipase (class 2); Region: Lipase_2; pfam01674 46234005953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234005954 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 46234005955 active site 46234005956 metal binding site [ion binding]; metal-binding site 46234005957 Integral membrane protein DUF92; Region: DUF92; pfam01940 46234005958 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 46234005959 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 46234005960 Ycf35; Provisional; Region: ycf35; CHL00193 46234005961 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 46234005962 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 46234005963 amidase catalytic site [active] 46234005964 Zn binding residues [ion binding]; other site 46234005965 substrate binding site [chemical binding]; other site 46234005966 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234005967 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234005968 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234005969 RloB-like protein; Region: RloB; pfam13707 46234005970 AAA domain; Region: AAA_21; pfam13304 46234005971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234005972 ABC transporter signature motif; other site 46234005973 Walker B; other site 46234005974 D-loop; other site 46234005975 H-loop/switch region; other site 46234005976 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 46234005977 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 46234005978 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 46234005979 dimerization interface [polypeptide binding]; other site 46234005980 active site 46234005981 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234005982 DNA methylase; Region: N6_N4_Mtase; pfam01555 46234005983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234005984 non-specific DNA binding site [nucleotide binding]; other site 46234005985 salt bridge; other site 46234005986 sequence-specific DNA binding site [nucleotide binding]; other site 46234005987 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 46234005988 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 46234005989 enolase; Provisional; Region: eno; PRK00077 46234005990 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 46234005991 dimer interface [polypeptide binding]; other site 46234005992 metal binding site [ion binding]; metal-binding site 46234005993 substrate binding pocket [chemical binding]; other site 46234005994 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 46234005995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234005996 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234005997 binding surface 46234005998 TPR motif; other site 46234005999 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006000 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 46234006001 XisI protein; Region: XisI; pfam08869 46234006002 XisH protein; Region: XisH; pfam08814 46234006003 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 46234006004 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234006005 putative active site [active] 46234006006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234006007 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 46234006008 dimer interface [polypeptide binding]; other site 46234006009 active site 46234006010 metal binding site [ion binding]; metal-binding site 46234006011 glutathione binding site [chemical binding]; other site 46234006012 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 46234006013 Clp amino terminal domain; Region: Clp_N; pfam02861 46234006014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234006015 Walker A motif; other site 46234006016 ATP binding site [chemical binding]; other site 46234006017 Walker B motif; other site 46234006018 arginine finger; other site 46234006019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234006020 Walker A motif; other site 46234006021 ATP binding site [chemical binding]; other site 46234006022 Walker B motif; other site 46234006023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 46234006024 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 46234006026 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234006027 Tetratricopeptide repeat; Region: TPR_10; pfam13374 46234006028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006030 binding surface 46234006031 TPR motif; other site 46234006032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006035 binding surface 46234006036 TPR motif; other site 46234006037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006040 binding surface 46234006041 TPR motif; other site 46234006042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234006043 heat shock protein 90; Provisional; Region: PRK05218 46234006044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006045 ATP binding site [chemical binding]; other site 46234006046 Mg2+ binding site [ion binding]; other site 46234006047 G-X-G motif; other site 46234006048 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 46234006049 Protein of unknown function (DUF497); Region: DUF497; pfam04365 46234006050 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 46234006051 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 46234006052 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 46234006053 active site 46234006054 metal binding site [ion binding]; metal-binding site 46234006055 Domain of unknown function (DUF305); Region: DUF305; pfam03713 46234006056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234006058 active site 46234006059 phosphorylation site [posttranslational modification] 46234006060 intermolecular recognition site; other site 46234006061 dimerization interface [polypeptide binding]; other site 46234006062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234006063 DNA binding site [nucleotide binding] 46234006064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234006065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234006066 phosphorylation site [posttranslational modification] 46234006067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006068 ATP binding site [chemical binding]; other site 46234006069 Mg2+ binding site [ion binding]; other site 46234006070 G-X-G motif; other site 46234006071 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 46234006072 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 46234006073 dimer interface [polypeptide binding]; other site 46234006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234006075 catalytic residue [active] 46234006076 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 46234006077 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 46234006078 putative active site cavity [active] 46234006079 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234006080 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 46234006081 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 46234006082 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 46234006083 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 46234006084 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234006085 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234006086 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234006087 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 46234006088 metal binding site 2 [ion binding]; metal-binding site 46234006089 putative DNA binding helix; other site 46234006090 metal binding site 1 [ion binding]; metal-binding site 46234006091 dimer interface [polypeptide binding]; other site 46234006092 structural Zn2+ binding site [ion binding]; other site 46234006093 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 46234006094 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 46234006095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234006096 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 46234006097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234006098 DNA binding residues [nucleotide binding] 46234006099 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 46234006100 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 46234006101 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 46234006102 lipoyl synthase; Provisional; Region: PRK05481 46234006103 HsdM N-terminal domain; Region: HsdM_N; pfam12161 46234006104 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 46234006105 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234006106 YcfA-like protein; Region: YcfA; cl00752 46234006107 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 46234006108 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 46234006109 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 46234006110 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 46234006111 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 46234006112 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 46234006113 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234006114 DEAD-like helicases superfamily; Region: DEXDc; smart00487 46234006115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234006116 ATP binding site [chemical binding]; other site 46234006117 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 46234006118 putative Mg++ binding site [ion binding]; other site 46234006119 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 46234006120 Staphylococcal nuclease homologues; Region: SNc; smart00318 46234006121 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 46234006122 Catalytic site; other site 46234006123 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 46234006124 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 46234006125 glutaminase active site [active] 46234006126 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 46234006127 dimer interface [polypeptide binding]; other site 46234006128 active site 46234006129 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 46234006130 dimer interface [polypeptide binding]; other site 46234006131 active site 46234006132 photosystem I subunit VII; Region: psaC; CHL00065 46234006133 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 46234006134 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 46234006135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 46234006136 Walker A/P-loop; other site 46234006137 ATP binding site [chemical binding]; other site 46234006138 Q-loop/lid; other site 46234006139 ABC transporter signature motif; other site 46234006140 Walker B; other site 46234006141 D-loop; other site 46234006142 H-loop/switch region; other site 46234006143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 46234006144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 46234006145 Walker A/P-loop; other site 46234006146 ATP binding site [chemical binding]; other site 46234006147 Q-loop/lid; other site 46234006148 ABC transporter signature motif; other site 46234006149 Walker B; other site 46234006150 D-loop; other site 46234006151 H-loop/switch region; other site 46234006152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 46234006153 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234006154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234006155 S-adenosylmethionine binding site [chemical binding]; other site 46234006156 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 46234006157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234006158 Coenzyme A binding pocket [chemical binding]; other site 46234006159 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 46234006160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 46234006161 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 46234006162 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234006163 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 46234006164 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 46234006165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 46234006166 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 46234006167 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 46234006168 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 46234006169 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 46234006170 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 46234006171 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 46234006172 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 46234006173 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 46234006174 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 46234006175 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 46234006176 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 46234006177 citrate synthase; Provisional; Region: PRK14036 46234006178 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 46234006179 dimer interface [polypeptide binding]; other site 46234006180 active site 46234006181 citrylCoA binding site [chemical binding]; other site 46234006182 oxalacetate/citrate binding site [chemical binding]; other site 46234006183 coenzyme A binding site [chemical binding]; other site 46234006184 catalytic triad [active] 46234006185 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 46234006186 catalytic core [active] 46234006187 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 46234006188 putative active site [active] 46234006189 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 46234006190 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 46234006191 DHH family; Region: DHH; pfam01368 46234006192 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234006193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234006194 active site 46234006195 alanine racemase; Reviewed; Region: alr; PRK00053 46234006196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 46234006197 active site 46234006198 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 46234006199 dimer interface [polypeptide binding]; other site 46234006200 substrate binding site [chemical binding]; other site 46234006201 catalytic residues [active] 46234006202 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 46234006203 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234006204 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234006205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 46234006206 dimer interface [polypeptide binding]; other site 46234006207 putative CheW interface [polypeptide binding]; other site 46234006208 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 46234006209 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 46234006210 putative binding surface; other site 46234006211 active site 46234006212 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 46234006213 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 46234006214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006215 ATP binding site [chemical binding]; other site 46234006216 Mg2+ binding site [ion binding]; other site 46234006217 G-X-G motif; other site 46234006218 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 46234006219 Response regulator receiver domain; Region: Response_reg; pfam00072 46234006220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234006221 active site 46234006222 phosphorylation site [posttranslational modification] 46234006223 intermolecular recognition site; other site 46234006224 dimerization interface [polypeptide binding]; other site 46234006225 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 46234006226 nudix motif; other site 46234006227 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 46234006228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 46234006229 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 46234006230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 46234006231 dimer interface [polypeptide binding]; other site 46234006232 conserved gate region; other site 46234006233 ABC-ATPase subunit interface; other site 46234006234 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 46234006235 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 46234006236 Walker A/P-loop; other site 46234006237 ATP binding site [chemical binding]; other site 46234006238 Q-loop/lid; other site 46234006239 ABC transporter signature motif; other site 46234006240 Walker B; other site 46234006241 D-loop; other site 46234006242 H-loop/switch region; other site 46234006243 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 46234006244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234006245 substrate binding pocket [chemical binding]; other site 46234006246 membrane-bound complex binding site; other site 46234006247 hinge residues; other site 46234006248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006249 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234006250 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 46234006251 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 46234006252 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 46234006253 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 46234006254 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 46234006255 lipoyl attachment site [posttranslational modification]; other site 46234006256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234006257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234006258 S-adenosylmethionine binding site [chemical binding]; other site 46234006259 PLD-like domain; Region: PLDc_2; pfam13091 46234006260 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 46234006261 putative active site [active] 46234006262 catalytic site [active] 46234006263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234006264 non-specific DNA binding site [nucleotide binding]; other site 46234006265 salt bridge; other site 46234006266 sequence-specific DNA binding site [nucleotide binding]; other site 46234006267 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 46234006268 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 46234006269 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 46234006270 dimer interface [polypeptide binding]; other site 46234006271 active site 46234006272 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 46234006273 active site 46234006274 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 46234006275 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 46234006276 D1 interface; other site 46234006277 chlorophyll binding site; other site 46234006278 pheophytin binding site; other site 46234006279 beta carotene binding site; other site 46234006280 cytochrome b559 beta interface; other site 46234006281 quinone binding site; other site 46234006282 cytochrome b559 alpha interface; other site 46234006283 protein J interface; other site 46234006284 protein H interface; other site 46234006285 protein X interface; other site 46234006286 core light harvesting protein interface; other site 46234006287 protein L interface; other site 46234006288 CP43 interface; other site 46234006289 protein T interface; other site 46234006290 Fe binding site [ion binding]; other site 46234006291 protein M interface; other site 46234006292 Mn-stabilizing polypeptide interface; other site 46234006293 bromide binding site; other site 46234006294 cytochrome c-550 interface; other site 46234006295 photosystem II 44 kDa protein; Region: psbC; CHL00035 46234006296 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 46234006297 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 46234006298 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 46234006299 Ligand Binding Site [chemical binding]; other site 46234006300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234006301 GAF domain; Region: GAF; pfam01590 46234006302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234006303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234006304 dimer interface [polypeptide binding]; other site 46234006305 phosphorylation site [posttranslational modification] 46234006306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006307 ATP binding site [chemical binding]; other site 46234006308 Mg2+ binding site [ion binding]; other site 46234006309 G-X-G motif; other site 46234006310 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 46234006311 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 46234006312 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 46234006313 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 46234006314 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234006315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234006316 active site 46234006317 phosphorylation site [posttranslational modification] 46234006318 intermolecular recognition site; other site 46234006319 dimerization interface [polypeptide binding]; other site 46234006320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006322 ATP binding site [chemical binding]; other site 46234006323 Mg2+ binding site [ion binding]; other site 46234006324 G-X-G motif; other site 46234006325 Response regulator receiver domain; Region: Response_reg; pfam00072 46234006326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234006327 active site 46234006328 phosphorylation site [posttranslational modification] 46234006329 intermolecular recognition site; other site 46234006330 dimerization interface [polypeptide binding]; other site 46234006331 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 46234006332 GAF domain; Region: GAF; pfam01590 46234006333 Phytochrome region; Region: PHY; pfam00360 46234006334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234006335 dimer interface [polypeptide binding]; other site 46234006336 phosphorylation site [posttranslational modification] 46234006337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234006338 ATP binding site [chemical binding]; other site 46234006339 Mg2+ binding site [ion binding]; other site 46234006340 G-X-G motif; other site 46234006341 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 46234006342 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 46234006343 iron-sulfur cluster [ion binding]; other site 46234006344 [2Fe-2S] cluster binding site [ion binding]; other site 46234006345 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 46234006346 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 46234006347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234006348 Walker A motif; other site 46234006349 ATP binding site [chemical binding]; other site 46234006350 Walker B motif; other site 46234006351 arginine finger; other site 46234006352 Phosphotransferase enzyme family; Region: APH; pfam01636 46234006353 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 46234006354 substrate binding site [chemical binding]; other site 46234006355 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 46234006356 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 46234006357 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 46234006358 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 46234006359 protein binding site [polypeptide binding]; other site 46234006360 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 46234006361 Catalytic dyad [active] 46234006362 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 46234006363 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006364 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006365 active site 46234006366 ATP binding site [chemical binding]; other site 46234006367 substrate binding site [chemical binding]; other site 46234006368 activation loop (A-loop); other site 46234006369 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 46234006370 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 46234006371 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234006372 catalytic triad [active] 46234006373 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 46234006374 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 46234006375 CheB methylesterase; Region: CheB_methylest; pfam01339 46234006376 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 46234006377 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 46234006378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234006379 S-adenosylmethionine binding site [chemical binding]; other site 46234006380 PAS domain; Region: PAS_9; pfam13426 46234006381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234006382 putative active site [active] 46234006383 heme pocket [chemical binding]; other site 46234006384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234006385 PAS domain; Region: PAS_9; pfam13426 46234006386 putative active site [active] 46234006387 heme pocket [chemical binding]; other site 46234006388 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 46234006389 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234006390 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 46234006391 catalytic triad [active] 46234006392 hypothetical protein; Provisional; Region: PRK02509 46234006393 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 46234006394 Uncharacterized conserved protein [Function unknown]; Region: COG1615 46234006395 carotene isomerase; Region: carot_isom; TIGR02730 46234006396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234006397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234006398 active site 46234006399 YGGT family; Region: YGGT; pfam02325 46234006400 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234006401 putative active site [active] 46234006402 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 46234006403 heterotetramer interface [polypeptide binding]; other site 46234006404 active site pocket [active] 46234006405 cleavage site 46234006406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006407 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006408 active site 46234006409 ATP binding site [chemical binding]; other site 46234006410 substrate binding site [chemical binding]; other site 46234006411 activation loop (A-loop); other site 46234006412 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234006413 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234006414 structural tetrad; other site 46234006415 DNA binding domain, excisionase family; Region: excise; TIGR01764 46234006416 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 46234006417 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 46234006418 putative NAD(P) binding site [chemical binding]; other site 46234006419 catalytic Zn binding site [ion binding]; other site 46234006420 glutamine synthetase, type I; Region: GlnA; TIGR00653 46234006421 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 46234006422 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 46234006423 allophycocyanin, beta subunit; Region: apcB; TIGR01337 46234006424 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 46234006425 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 46234006426 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234006427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006428 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234006429 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 46234006430 Probable Catalytic site; other site 46234006431 metal-binding site 46234006432 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234006433 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 46234006434 Probable Catalytic site; other site 46234006435 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234006436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006437 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 46234006438 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 46234006439 active site 46234006440 homodimer interface [polypeptide binding]; other site 46234006441 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 46234006442 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 46234006443 NAD(P) binding site [chemical binding]; other site 46234006444 homodimer interface [polypeptide binding]; other site 46234006445 substrate binding site [chemical binding]; other site 46234006446 active site 46234006447 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 46234006448 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 46234006449 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 46234006450 NADP binding site [chemical binding]; other site 46234006451 active site 46234006452 putative substrate binding site [chemical binding]; other site 46234006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234006454 S-adenosylmethionine binding site [chemical binding]; other site 46234006455 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 46234006456 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 46234006457 Walker A/P-loop; other site 46234006458 ATP binding site [chemical binding]; other site 46234006459 Q-loop/lid; other site 46234006460 ABC transporter signature motif; other site 46234006461 Walker B; other site 46234006462 D-loop; other site 46234006463 H-loop/switch region; other site 46234006464 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 46234006465 putative carbohydrate binding site [chemical binding]; other site 46234006466 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 46234006467 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 46234006468 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 46234006469 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234006470 active site 46234006471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234006472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234006474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234006475 active site 46234006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 46234006477 ABC-2 type transporter; Region: ABC2_membrane; cl17235 46234006478 thiamine monophosphate kinase; Provisional; Region: PRK05731 46234006479 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 46234006480 ATP binding site [chemical binding]; other site 46234006481 dimerization interface [polypeptide binding]; other site 46234006482 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 46234006483 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 46234006484 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 46234006485 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 46234006486 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 46234006487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234006488 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234006489 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 46234006490 FAD binding domain; Region: FAD_binding_4; pfam01565 46234006491 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 46234006492 hypothetical protein; Validated; Region: PRK00153 46234006493 AAA domain; Region: AAA_21; pfam13304 46234006494 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 46234006495 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 46234006496 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 46234006497 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 46234006498 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 46234006499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234006500 Caspase domain; Region: Peptidase_C14; pfam00656 46234006501 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 46234006502 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234006503 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 46234006504 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234006505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234006506 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 46234006507 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 46234006508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 46234006509 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 46234006510 DHH family; Region: DHH; pfam01368 46234006511 DHHA1 domain; Region: DHHA1; pfam02272 46234006512 CAAX protease self-immunity; Region: Abi; pfam02517 46234006513 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 46234006514 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 46234006515 metal-binding site [ion binding] 46234006516 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234006517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234006518 active site 46234006519 motif I; other site 46234006520 motif II; other site 46234006521 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 46234006522 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 46234006523 putative NAD(P) binding site [chemical binding]; other site 46234006524 putative active site [active] 46234006525 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 46234006526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 46234006527 active site 46234006528 catalytic tetrad [active] 46234006529 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234006530 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234006531 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006532 Ca2+ binding site [ion binding]; other site 46234006533 Cadherin repeat-like domain; Region: CA_like; cl15786 46234006534 Ca2+ binding site [ion binding]; other site 46234006535 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006536 Ca2+ binding site [ion binding]; other site 46234006537 legume lectins, lectin-like receptor kinases, arcelin, concanavalinA, and alpha-amylase inhibitor; Region: lectin_legume_LecRK_Arcelin_ConA; cd06899 46234006538 homodimer interaction site [polypeptide binding]; other site 46234006539 homotetramer interaction site [polypeptide binding]; other site 46234006540 N-linked glycosylation site; other site 46234006541 metal binding site [ion binding]; metal-binding site 46234006542 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 46234006543 RHS Repeat; Region: RHS_repeat; cl11982 46234006544 RHS Repeat; Region: RHS_repeat; pfam05593 46234006545 RHS Repeat; Region: RHS_repeat; pfam05593 46234006546 RHS Repeat; Region: RHS_repeat; pfam05593 46234006547 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 46234006548 RHS Repeat; Region: RHS_repeat; pfam05593 46234006549 RHS Repeat; Region: RHS_repeat; pfam05593 46234006550 RHS Repeat; Region: RHS_repeat; pfam05593 46234006551 RHS Repeat; Region: RHS_repeat; cl11982 46234006552 RHS Repeat; Region: RHS_repeat; pfam05593 46234006553 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 46234006554 RHS Repeat; Region: RHS_repeat; pfam05593 46234006555 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 46234006556 RHS Repeat; Region: RHS_repeat; pfam05593 46234006557 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 46234006558 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 46234006559 putative active site [active] 46234006560 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 46234006561 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234006562 TPR repeat; Region: TPR_11; pfam13414 46234006563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006564 binding surface 46234006565 TPR motif; other site 46234006566 TPR repeat; Region: TPR_11; pfam13414 46234006567 TPR repeat; Region: TPR_11; pfam13414 46234006568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006569 binding surface 46234006570 TPR motif; other site 46234006571 TPR repeat; Region: TPR_11; pfam13414 46234006572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006573 binding surface 46234006574 TPR motif; other site 46234006575 TPR repeat; Region: TPR_11; pfam13414 46234006576 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 46234006577 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 46234006578 dimer interface [polypeptide binding]; other site 46234006579 decamer (pentamer of dimers) interface [polypeptide binding]; other site 46234006580 catalytic triad [active] 46234006581 peroxidatic and resolving cysteines [active] 46234006582 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 46234006583 putative catalytic residues [active] 46234006584 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234006585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006586 TPR repeat; Region: TPR_11; pfam13414 46234006587 binding surface 46234006588 TPR motif; other site 46234006589 TPR repeat; Region: TPR_11; pfam13414 46234006590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006591 binding surface 46234006592 TPR motif; other site 46234006593 TPR repeat; Region: TPR_11; pfam13414 46234006594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006595 TPR motif; other site 46234006596 binding surface 46234006597 TPR repeat; Region: TPR_11; pfam13414 46234006598 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234006599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234006600 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234006601 Probable transposase; Region: OrfB_IS605; pfam01385 46234006602 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234006603 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234006604 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234006605 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 46234006606 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 46234006607 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 46234006608 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 46234006609 substrate binding site; other site 46234006610 metal-binding site 46234006611 Oligomer interface; other site 46234006612 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 46234006613 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 46234006614 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 46234006615 NADP binding site [chemical binding]; other site 46234006616 active site 46234006617 putative substrate binding site [chemical binding]; other site 46234006618 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 46234006619 Uncharacterized conserved protein [Function unknown]; Region: COG1434 46234006620 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 46234006621 putative active site [active] 46234006622 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234006623 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006625 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234006626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006627 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234006628 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234006630 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 46234006631 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 46234006632 HD domain; Region: HD_5; pfam13487 46234006633 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 46234006634 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 46234006635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234006636 FeS/SAM binding site; other site 46234006637 Protein of unknown function (DUF760); Region: DUF760; pfam05542 46234006638 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 46234006639 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 46234006640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234006641 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 46234006642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234006643 DNA binding residues [nucleotide binding] 46234006644 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 46234006645 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 46234006646 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 46234006647 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 46234006648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 46234006649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 46234006650 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 46234006651 IMP binding site; other site 46234006652 dimer interface [polypeptide binding]; other site 46234006653 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 46234006654 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 46234006655 dimerization interface [polypeptide binding]; other site 46234006656 DPS ferroxidase diiron center [ion binding]; other site 46234006657 ion pore; other site 46234006658 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 46234006659 dimer interface [polypeptide binding]; other site 46234006660 [2Fe-2S] cluster binding site [ion binding]; other site 46234006661 Restriction endonuclease; Region: Mrr_cat; pfam04471 46234006662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006663 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006664 active site 46234006665 ATP binding site [chemical binding]; other site 46234006666 substrate binding site [chemical binding]; other site 46234006667 activation loop (A-loop); other site 46234006668 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 46234006669 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 46234006670 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234006671 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 46234006672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234006673 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234006674 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234006675 Hexamer interface [polypeptide binding]; other site 46234006676 Hexagonal pore residue; other site 46234006677 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234006678 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234006679 Hexamer interface [polypeptide binding]; other site 46234006680 Hexagonal pore residue; other site 46234006681 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 46234006682 Hexamer/Pentamer interface [polypeptide binding]; other site 46234006683 central pore; other site 46234006684 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 46234006685 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 46234006686 trimer interface [polypeptide binding]; other site 46234006687 active site 46234006688 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 46234006689 putative multimerization interface [polypeptide binding]; other site 46234006690 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 46234006691 putative multimerization interface [polypeptide binding]; other site 46234006692 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 46234006693 putative multimerization interface [polypeptide binding]; other site 46234006694 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 46234006695 putative trimer interface [polypeptide binding]; other site 46234006696 putative CoA binding site [chemical binding]; other site 46234006697 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234006698 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234006699 Hexamer interface [polypeptide binding]; other site 46234006700 Hexagonal pore residue; other site 46234006701 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234006702 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234006703 Hexamer interface [polypeptide binding]; other site 46234006704 Hexagonal pore residue; other site 46234006705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234006706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234006707 active site 46234006708 phosphorylation site [posttranslational modification] 46234006709 intermolecular recognition site; other site 46234006710 dimerization interface [polypeptide binding]; other site 46234006711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234006712 DNA binding site [nucleotide binding] 46234006713 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 46234006714 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 46234006715 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 46234006716 homodimer interface [polypeptide binding]; other site 46234006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234006718 catalytic residue [active] 46234006719 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 46234006720 active site 46234006721 ribulose/triose binding site [chemical binding]; other site 46234006722 phosphate binding site [ion binding]; other site 46234006723 substrate (anthranilate) binding pocket [chemical binding]; other site 46234006724 product (indole) binding pocket [chemical binding]; other site 46234006725 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 46234006726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234006727 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 46234006728 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 46234006729 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 46234006730 RNA binding site [nucleotide binding]; other site 46234006731 active site 46234006732 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 46234006733 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 46234006734 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 46234006735 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 46234006736 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 46234006737 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 46234006738 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 46234006739 DNA protecting protein DprA; Region: dprA; TIGR00732 46234006740 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 46234006741 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 46234006742 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 46234006743 Walker A/P-loop; other site 46234006744 ATP binding site [chemical binding]; other site 46234006745 Q-loop/lid; other site 46234006746 ABC transporter signature motif; other site 46234006747 Walker B; other site 46234006748 D-loop; other site 46234006749 H-loop/switch region; other site 46234006750 Ferredoxin [Energy production and conversion]; Region: COG1146 46234006751 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 46234006752 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 46234006753 dimer interface [polypeptide binding]; other site 46234006754 motif 1; other site 46234006755 active site 46234006756 motif 2; other site 46234006757 motif 3; other site 46234006758 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 46234006759 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234006760 HSP70 interaction site [polypeptide binding]; other site 46234006761 TPR repeat; Region: TPR_11; pfam13414 46234006762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234006763 binding surface 46234006764 TPR motif; other site 46234006765 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234006766 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234006767 ribonuclease Z; Region: RNase_Z; TIGR02651 46234006768 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 46234006769 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 46234006770 catalytic triad [active] 46234006771 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 46234006772 four helix bundle protein; Region: TIGR02436 46234006773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 46234006774 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 46234006775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234006776 catalytic residue [active] 46234006777 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 46234006778 Family of unknown function (DUF490); Region: DUF490; pfam04357 46234006779 Family of unknown function (DUF490); Region: DUF490; pfam04357 46234006780 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 46234006781 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 46234006782 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 46234006783 putative active site [active] 46234006784 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 46234006785 tetramer (dimer of dimers) interface [polypeptide binding]; other site 46234006786 active site 46234006787 dimer interface [polypeptide binding]; other site 46234006788 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 46234006789 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 46234006790 metal binding site [ion binding]; metal-binding site 46234006791 dimer interface [polypeptide binding]; other site 46234006792 AAA domain; Region: AAA_26; pfam13500 46234006793 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 46234006794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234006795 Probable transposase; Region: OrfB_IS605; pfam01385 46234006796 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 46234006797 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006799 active site 46234006800 ATP binding site [chemical binding]; other site 46234006801 substrate binding site [chemical binding]; other site 46234006802 activation loop (A-loop); other site 46234006803 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 46234006804 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 46234006805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234006806 active site 46234006807 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 46234006808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 46234006809 Zn2+ binding site [ion binding]; other site 46234006810 Mg2+ binding site [ion binding]; other site 46234006811 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006812 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006813 active site 46234006814 ATP binding site [chemical binding]; other site 46234006815 substrate binding site [chemical binding]; other site 46234006816 activation loop (A-loop); other site 46234006817 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 46234006818 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 46234006819 G1 box; other site 46234006820 putative GEF interaction site [polypeptide binding]; other site 46234006821 GTP/Mg2+ binding site [chemical binding]; other site 46234006822 Switch I region; other site 46234006823 G2 box; other site 46234006824 G3 box; other site 46234006825 Switch II region; other site 46234006826 G4 box; other site 46234006827 G5 box; other site 46234006828 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 46234006829 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 46234006830 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 46234006831 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 46234006832 Cl- selectivity filter; other site 46234006833 Cl- binding residues [ion binding]; other site 46234006834 pore gating glutamate residue; other site 46234006835 dimer interface [polypeptide binding]; other site 46234006836 H+/Cl- coupling transport residue; other site 46234006837 FOG: CBS domain [General function prediction only]; Region: COG0517 46234006838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 46234006839 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 46234006840 Ligand Binding Site [chemical binding]; other site 46234006841 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 46234006842 Ligand Binding Site [chemical binding]; other site 46234006843 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234006844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234006845 active site 46234006846 ATP binding site [chemical binding]; other site 46234006847 substrate binding site [chemical binding]; other site 46234006848 activation loop (A-loop); other site 46234006849 GUN4-like; Region: GUN4; pfam05419 46234006850 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 46234006851 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 46234006852 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 46234006853 Fe-S cluster binding site [ion binding]; other site 46234006854 active site 46234006855 competence damage-inducible protein A; Provisional; Region: PRK00549 46234006856 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 46234006857 putative MPT binding site; other site 46234006858 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 46234006859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006860 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 46234006861 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 46234006862 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 46234006863 NADP-binding site; other site 46234006864 homotetramer interface [polypeptide binding]; other site 46234006865 substrate binding site [chemical binding]; other site 46234006866 homodimer interface [polypeptide binding]; other site 46234006867 active site 46234006868 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234006869 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 46234006870 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 46234006871 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234006872 putative active site [active] 46234006873 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234006874 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 46234006875 inhibitor binding site; inhibition site 46234006876 catalytic motif [active] 46234006877 Catalytic residue [active] 46234006878 Active site flap [active] 46234006879 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 46234006880 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 46234006881 Walker A/P-loop; other site 46234006882 ATP binding site [chemical binding]; other site 46234006883 Q-loop/lid; other site 46234006884 ABC transporter signature motif; other site 46234006885 Walker B; other site 46234006886 D-loop; other site 46234006887 H-loop/switch region; other site 46234006888 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 46234006889 putative carbohydrate binding site [chemical binding]; other site 46234006890 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 46234006891 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 46234006892 inhibitor-cofactor binding pocket; inhibition site 46234006893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234006894 catalytic residue [active] 46234006895 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 46234006896 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 46234006897 Coenzyme A binding pocket [chemical binding]; other site 46234006898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006899 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234006900 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234006901 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 46234006902 metal-binding site 46234006903 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234006904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006905 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234006906 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234006907 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234006908 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234006909 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234006910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006911 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 46234006912 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234006913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006914 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 46234006915 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 46234006916 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234006917 active site 46234006918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006919 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234006920 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234006921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 46234006923 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 46234006924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234006926 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 46234006927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234006928 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 46234006929 putative ADP-binding pocket [chemical binding]; other site 46234006930 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234006931 putative active site [active] 46234006932 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234006933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234006934 S-adenosylmethionine binding site [chemical binding]; other site 46234006935 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 46234006936 putative metal binding site; other site 46234006937 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 46234006938 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 46234006939 putative active site [active] 46234006940 Uncharacterized conserved protein [Function unknown]; Region: COG1434 46234006941 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 46234006942 putative active site [active] 46234006943 putative acyl transferase; Provisional; Region: PRK10502 46234006944 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 46234006945 putative trimer interface [polypeptide binding]; other site 46234006946 putative active site [active] 46234006947 putative substrate binding site [chemical binding]; other site 46234006948 putative CoA binding site [chemical binding]; other site 46234006949 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 46234006950 Chain length determinant protein; Region: Wzz; pfam02706 46234006951 Chain length determinant protein; Region: Wzz; cl15801 46234006952 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 46234006953 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234006954 Nucleotide binding site [chemical binding]; other site 46234006955 P loop; other site 46234006956 DTAP/Switch II; other site 46234006957 Switch I; other site 46234006958 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 46234006959 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 46234006960 active site 46234006961 substrate binding site [chemical binding]; other site 46234006962 FMN binding site [chemical binding]; other site 46234006963 putative catalytic residues [active] 46234006964 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 46234006965 methionine sulfoxide reductase A; Provisional; Region: PRK00058 46234006966 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 46234006967 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 46234006968 30S subunit binding site; other site 46234006969 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 46234006970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234006971 catalytic triad [active] 46234006972 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006973 Ca2+ binding site [ion binding]; other site 46234006974 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006975 Ca2+ binding site [ion binding]; other site 46234006976 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234006977 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006978 Ca2+ binding site [ion binding]; other site 46234006979 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234006980 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006981 Ca2+ binding site [ion binding]; other site 46234006982 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 46234006983 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 46234006984 Ca2+ binding site [ion binding]; other site 46234006985 Calx-beta domain; Region: Calx-beta; pfam03160 46234006986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 46234006987 HEPN domain; Region: HEPN; cl00824 46234006988 AAA domain; Region: AAA_31; pfam13614 46234006989 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234006990 P-loop; other site 46234006991 Magnesium ion binding site [ion binding]; other site 46234006992 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234006993 GTPase CgtA; Reviewed; Region: obgE; PRK12299 46234006994 GTP1/OBG; Region: GTP1_OBG; pfam01018 46234006995 Obg GTPase; Region: Obg; cd01898 46234006996 G1 box; other site 46234006997 GTP/Mg2+ binding site [chemical binding]; other site 46234006998 Switch I region; other site 46234006999 G2 box; other site 46234007000 G3 box; other site 46234007001 Switch II region; other site 46234007002 G4 box; other site 46234007003 G5 box; other site 46234007004 tellurium resistance terB-like protein; Region: terB_like; cd07177 46234007005 metal binding site [ion binding]; metal-binding site 46234007006 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 46234007007 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 46234007008 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 46234007009 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 46234007010 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 46234007011 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 46234007012 C-terminal domain interface [polypeptide binding]; other site 46234007013 glycogen branching enzyme; Provisional; Region: PRK05402 46234007014 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 46234007015 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 46234007016 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 46234007017 active site 46234007018 catalytic site [active] 46234007019 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 46234007020 Probable transposase; Region: OrfB_IS605; pfam01385 46234007021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234007022 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 46234007023 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 46234007024 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 46234007025 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 46234007026 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 46234007027 intersubunit interface [polypeptide binding]; other site 46234007028 active site 46234007029 zinc binding site [ion binding]; other site 46234007030 Na+ binding site [ion binding]; other site 46234007031 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234007032 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 46234007033 homotrimer interface [polypeptide binding]; other site 46234007034 Walker A motif; other site 46234007035 GTP binding site [chemical binding]; other site 46234007036 Walker B motif; other site 46234007037 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 46234007038 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 46234007039 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234007040 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234007041 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 46234007042 Putative methyltransferase; Region: Methyltransf_4; cl17290 46234007043 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234007044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234007045 S-adenosylmethionine binding site [chemical binding]; other site 46234007046 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 46234007047 active site residue [active] 46234007048 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 46234007049 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 46234007050 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 46234007051 trimer interface [polypeptide binding]; other site 46234007052 active site 46234007053 substrate binding site [chemical binding]; other site 46234007054 CoA binding site [chemical binding]; other site 46234007055 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 46234007056 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 46234007057 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 46234007058 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 46234007059 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 46234007060 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 46234007061 putative active site [active] 46234007062 putative NTP binding site [chemical binding]; other site 46234007063 putative nucleic acid binding site [nucleotide binding]; other site 46234007064 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 46234007065 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234007066 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234007067 active site 46234007068 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 46234007069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234007070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234007071 homodimer interface [polypeptide binding]; other site 46234007072 catalytic residue [active] 46234007073 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 46234007074 RimM N-terminal domain; Region: RimM; pfam01782 46234007075 PRC-barrel domain; Region: PRC; pfam05239 46234007076 Ferritin-like domain; Region: Ferritin; pfam00210 46234007077 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 46234007078 dinuclear metal binding motif [ion binding]; other site 46234007079 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 46234007080 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 46234007081 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 46234007082 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 46234007083 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234007084 putative active site [active] 46234007085 TPR repeat; Region: TPR_11; pfam13414 46234007086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007087 binding surface 46234007088 TPR motif; other site 46234007089 TPR repeat; Region: TPR_11; pfam13414 46234007090 TPR repeat; Region: TPR_11; pfam13414 46234007091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007092 binding surface 46234007093 TPR motif; other site 46234007094 TPR repeat; Region: TPR_11; pfam13414 46234007095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007096 binding surface 46234007097 TPR motif; other site 46234007098 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 46234007099 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 46234007100 PDGLE domain; Region: PDGLE; pfam13190 46234007101 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 46234007102 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234007103 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 46234007104 Walker A/P-loop; other site 46234007105 ATP binding site [chemical binding]; other site 46234007106 Q-loop/lid; other site 46234007107 ABC transporter signature motif; other site 46234007108 Walker B; other site 46234007109 D-loop; other site 46234007110 H-loop/switch region; other site 46234007111 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 46234007112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234007113 ATP binding site [chemical binding]; other site 46234007114 putative Mg++ binding site [ion binding]; other site 46234007115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234007116 nucleotide binding region [chemical binding]; other site 46234007117 ATP-binding site [chemical binding]; other site 46234007118 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 46234007119 active site 46234007120 dimer interface [polypeptide binding]; other site 46234007121 catalytic nucleophile [active] 46234007122 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 46234007123 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 46234007124 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 46234007125 quinone interaction residues [chemical binding]; other site 46234007126 active site 46234007127 catalytic residues [active] 46234007128 FMN binding site [chemical binding]; other site 46234007129 substrate binding site [chemical binding]; other site 46234007130 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 46234007131 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 46234007132 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 46234007133 catalytic motif [active] 46234007134 Zn binding site [ion binding]; other site 46234007135 RibD C-terminal domain; Region: RibD_C; cl17279 46234007136 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 46234007137 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234007138 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007140 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007141 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234007142 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234007144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234007145 active site 46234007146 phosphorylation site [posttranslational modification] 46234007147 intermolecular recognition site; other site 46234007148 dimerization interface [polypeptide binding]; other site 46234007149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234007150 DNA binding site [nucleotide binding] 46234007151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234007152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234007153 dimer interface [polypeptide binding]; other site 46234007154 phosphorylation site [posttranslational modification] 46234007155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234007156 ATP binding site [chemical binding]; other site 46234007157 Mg2+ binding site [ion binding]; other site 46234007158 G-X-G motif; other site 46234007159 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 46234007160 PhoU domain; Region: PhoU; pfam01895 46234007161 PhoU domain; Region: PhoU; pfam01895 46234007162 S-layer homology domain; Region: SLH; pfam00395 46234007163 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 46234007164 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 46234007165 FAD binding domain; Region: FAD_binding_4; pfam01565 46234007166 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 46234007167 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 46234007168 Cysteine-rich domain; Region: CCG; pfam02754 46234007169 Cysteine-rich domain; Region: CCG; pfam02754 46234007170 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234007171 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 46234007172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234007173 S-adenosylmethionine binding site [chemical binding]; other site 46234007174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234007175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234007176 active site 46234007177 ATP binding site [chemical binding]; other site 46234007178 substrate binding site [chemical binding]; other site 46234007179 activation loop (A-loop); other site 46234007180 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234007181 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234007182 phosphoribulokinase; Provisional; Region: PRK07429 46234007183 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 46234007184 active site 46234007185 hypothetical protein; Reviewed; Region: PRK00024 46234007186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 46234007187 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 46234007188 MPN+ (JAMM) motif; other site 46234007189 Zinc-binding site [ion binding]; other site 46234007190 Uncharacterized conserved protein [Function unknown]; Region: COG4095 46234007191 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 46234007192 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 46234007193 B12 binding site [chemical binding]; other site 46234007194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234007195 FeS/SAM binding site; other site 46234007196 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234007197 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234007198 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234007199 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 46234007200 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 46234007201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 46234007202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 46234007203 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234007204 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234007205 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234007206 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234007207 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234007208 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234007209 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 46234007210 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 46234007211 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 46234007212 motif 1; other site 46234007213 active site 46234007214 motif 2; other site 46234007215 motif 3; other site 46234007216 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 46234007217 DHHA1 domain; Region: DHHA1; pfam02272 46234007218 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234007219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007221 AAA domain; Region: AAA_21; pfam13304 46234007222 Walker A/P-loop; other site 46234007223 Walker A/P-loop; other site 46234007224 ATP binding site [chemical binding]; other site 46234007225 ATP binding site [chemical binding]; other site 46234007226 Q-loop/lid; other site 46234007227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007228 ABC transporter signature motif; other site 46234007229 Walker B; other site 46234007230 D-loop; other site 46234007231 H-loop/switch region; other site 46234007232 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 46234007233 active site 46234007234 metal binding site [ion binding]; metal-binding site 46234007235 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234007236 putative active site [active] 46234007237 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 46234007238 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 46234007239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234007240 catalytic residue [active] 46234007241 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 46234007242 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 46234007243 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 46234007244 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 46234007245 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 46234007246 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234007247 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 46234007248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234007249 active site 46234007250 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 46234007251 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 46234007252 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 46234007253 Active site cavity [active] 46234007254 catalytic acid [active] 46234007255 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 46234007256 Predicted membrane protein [Function unknown]; Region: COG1950 46234007257 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234007258 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234007259 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234007260 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234007261 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234007262 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234007263 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234007264 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234007265 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234007266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234007267 S-adenosylmethionine binding site [chemical binding]; other site 46234007268 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 46234007269 Glucose inhibited division protein A; Region: GIDA; pfam01134 46234007270 YcfA-like protein; Region: YcfA; cl00752 46234007271 L-asparaginase II; Region: Asparaginase_II; cl01842 46234007272 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 46234007273 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 46234007274 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 46234007275 anti sigma factor interaction site; other site 46234007276 regulatory phosphorylation site [posttranslational modification]; other site 46234007277 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 46234007278 Bacterial sugar transferase; Region: Bac_transf; pfam02397 46234007279 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 46234007280 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 46234007281 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 46234007282 putative active site [active] 46234007283 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 46234007284 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 46234007285 tRNA; other site 46234007286 putative tRNA binding site [nucleotide binding]; other site 46234007287 putative NADP binding site [chemical binding]; other site 46234007288 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 46234007289 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 46234007290 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 46234007291 Ligand Binding Site [chemical binding]; other site 46234007292 Molecular Tunnel; other site 46234007293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007294 AAA domain; Region: AAA_21; pfam13304 46234007295 Walker A/P-loop; other site 46234007296 ATP binding site [chemical binding]; other site 46234007297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007298 Q-loop/lid; other site 46234007299 ABC transporter signature motif; other site 46234007300 Walker B; other site 46234007301 D-loop; other site 46234007302 H-loop/switch region; other site 46234007303 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 46234007304 active site 46234007305 metal binding site [ion binding]; metal-binding site 46234007306 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 46234007307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 46234007308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 46234007309 catalytic residue [active] 46234007310 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 46234007311 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 46234007312 Ligand Binding Site [chemical binding]; other site 46234007313 Molecular Tunnel; other site 46234007314 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 46234007315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234007316 Walker A motif; other site 46234007317 ATP binding site [chemical binding]; other site 46234007318 Walker B motif; other site 46234007319 arginine finger; other site 46234007320 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 46234007321 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 46234007322 metal ion-dependent adhesion site (MIDAS); other site 46234007323 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234007324 transaldolase-like protein; Provisional; Region: PTZ00411 46234007325 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 46234007326 active site 46234007327 dimer interface [polypeptide binding]; other site 46234007328 catalytic residue [active] 46234007329 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 46234007330 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 46234007331 domain interfaces; other site 46234007332 active site 46234007333 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 46234007334 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 46234007335 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 46234007336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234007337 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234007338 Probable transposase; Region: OrfB_IS605; pfam01385 46234007339 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234007340 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 46234007341 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 46234007342 catalytic site [active] 46234007343 G-X2-G-X-G-K; other site 46234007344 hypothetical protein; Provisional; Region: PRK04323 46234007345 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 46234007346 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 46234007347 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 46234007348 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 46234007349 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 46234007350 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 46234007351 substrate binding pocket [chemical binding]; other site 46234007352 chain length determination region; other site 46234007353 substrate-Mg2+ binding site; other site 46234007354 catalytic residues [active] 46234007355 aspartate-rich region 1; other site 46234007356 active site lid residues [active] 46234007357 aspartate-rich region 2; other site 46234007358 glutamate racemase; Provisional; Region: PRK00865 46234007359 AMIN domain; Region: AMIN; pfam11741 46234007360 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234007361 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234007362 active site 46234007363 metal binding site [ion binding]; metal-binding site 46234007364 AMIN domain; Region: AMIN; pfam11741 46234007365 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234007366 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234007367 active site 46234007368 metal binding site [ion binding]; metal-binding site 46234007369 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 46234007370 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 46234007371 Proline dehydrogenase; Region: Pro_dh; pfam01619 46234007372 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 46234007373 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 46234007374 Glutamate binding site [chemical binding]; other site 46234007375 homodimer interface [polypeptide binding]; other site 46234007376 NAD binding site [chemical binding]; other site 46234007377 catalytic residues [active] 46234007378 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234007379 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234007380 TPR repeat; Region: TPR_11; pfam13414 46234007381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007382 TPR motif; other site 46234007383 binding surface 46234007384 TPR repeat; Region: TPR_11; pfam13414 46234007385 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 46234007386 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 46234007387 Chromate transporter; Region: Chromate_transp; pfam02417 46234007388 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 46234007389 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 46234007390 putative active site [active] 46234007391 catalytic site [active] 46234007392 putative metal binding site [ion binding]; other site 46234007393 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 46234007394 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 46234007395 nucleotide binding pocket [chemical binding]; other site 46234007396 K-X-D-G motif; other site 46234007397 catalytic site [active] 46234007398 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 46234007399 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 46234007400 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 46234007401 Dimer interface [polypeptide binding]; other site 46234007402 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 46234007403 Fasciclin domain; Region: Fasciclin; pfam02469 46234007404 cobalt transport protein CbiM; Validated; Region: PRK08319 46234007405 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 46234007406 cobalt transport protein CbiN; Provisional; Region: PRK02898 46234007407 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 46234007408 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234007409 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 46234007410 Walker A/P-loop; other site 46234007411 ATP binding site [chemical binding]; other site 46234007412 Q-loop/lid; other site 46234007413 ABC transporter signature motif; other site 46234007414 Walker B; other site 46234007415 D-loop; other site 46234007416 H-loop/switch region; other site 46234007417 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 46234007418 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 46234007419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234007420 active site 46234007421 TPR repeat; Region: TPR_11; pfam13414 46234007422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007423 binding surface 46234007424 TPR motif; other site 46234007425 TPR repeat; Region: TPR_11; pfam13414 46234007426 TPR repeat; Region: TPR_11; pfam13414 46234007427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007428 binding surface 46234007429 TPR motif; other site 46234007430 TPR repeat; Region: TPR_11; pfam13414 46234007431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007432 binding surface 46234007433 TPR motif; other site 46234007434 TPR repeat; Region: TPR_11; pfam13414 46234007435 TPR repeat; Region: TPR_11; pfam13414 46234007436 Tetratricopeptide repeat; Region: TPR_1; pfam00515 46234007437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007438 binding surface 46234007439 TPR motif; other site 46234007440 TPR repeat; Region: TPR_11; pfam13414 46234007441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007442 binding surface 46234007443 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234007444 TPR motif; other site 46234007445 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 46234007446 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 46234007447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007448 AAA domain; Region: AAA_21; pfam13304 46234007449 Walker A/P-loop; other site 46234007450 ATP binding site [chemical binding]; other site 46234007451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234007452 Q-loop/lid; other site 46234007453 ABC transporter signature motif; other site 46234007454 Walker B; other site 46234007455 D-loop; other site 46234007456 H-loop/switch region; other site 46234007457 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 46234007458 active site 46234007459 metal binding site [ion binding]; metal-binding site 46234007460 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 46234007461 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 46234007462 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 46234007463 UbiA prenyltransferase family; Region: UbiA; pfam01040 46234007464 GAF domain; Region: GAF_3; pfam13492 46234007465 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 46234007466 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 46234007467 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234007468 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 46234007469 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 46234007470 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 46234007471 P loop; other site 46234007472 GTP binding site [chemical binding]; other site 46234007473 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 46234007474 putative RNA binding site [nucleotide binding]; other site 46234007475 Uncharacterized conserved protein [Function unknown]; Region: COG2928 46234007476 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 46234007477 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 46234007478 active site 46234007479 homodimer interface [polypeptide binding]; other site 46234007480 SnoaL-like domain; Region: SnoaL_2; pfam12680 46234007481 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 46234007482 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 46234007483 putative NAD(P) binding site [chemical binding]; other site 46234007484 homodimer interface [polypeptide binding]; other site 46234007485 homotetramer interface [polypeptide binding]; other site 46234007486 active site 46234007487 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234007488 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234007489 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 46234007490 Ligand Binding Site [chemical binding]; other site 46234007491 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 46234007492 Phosphoglycerate kinase; Region: PGK; pfam00162 46234007493 substrate binding site [chemical binding]; other site 46234007494 hinge regions; other site 46234007495 ADP binding site [chemical binding]; other site 46234007496 catalytic site [active] 46234007497 PemK-like protein; Region: PemK; pfam02452 46234007498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234007499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234007500 active site 46234007501 ATP binding site [chemical binding]; other site 46234007502 substrate binding site [chemical binding]; other site 46234007503 activation loop (A-loop); other site 46234007504 Cytochrome b562; Region: Cytochrom_B562; cl01546 46234007505 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 46234007506 putative active site [active] 46234007507 homotetrameric interface [polypeptide binding]; other site 46234007508 metal binding site [ion binding]; metal-binding site 46234007509 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234007510 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234007511 putative active site [active] 46234007512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 46234007513 SPFH domain / Band 7 family; Region: Band_7; pfam01145 46234007514 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 46234007515 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 46234007516 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234007517 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 46234007518 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 46234007519 gamma subunit interface [polypeptide binding]; other site 46234007520 epsilon subunit interface [polypeptide binding]; other site 46234007521 LBP interface [polypeptide binding]; other site 46234007522 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 46234007523 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 46234007524 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 46234007525 alpha subunit interaction interface [polypeptide binding]; other site 46234007526 Walker A motif; other site 46234007527 ATP binding site [chemical binding]; other site 46234007528 Walker B motif; other site 46234007529 inhibitor binding site; inhibition site 46234007530 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 46234007531 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 46234007532 Phage-related protein [Function unknown]; Region: COG4695; cl01923 46234007533 Uncharacterized conserved protein [Function unknown]; Region: COG2912 46234007534 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 46234007535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 46234007536 binding surface 46234007537 TPR motif; other site 46234007538 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234007539 Dynamin family; Region: Dynamin_N; pfam00350 46234007540 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 46234007541 G1 box; other site 46234007542 GTP/Mg2+ binding site [chemical binding]; other site 46234007543 Switch I region; other site 46234007544 G2 box; other site 46234007545 Switch II region; other site 46234007546 G3 box; other site 46234007547 G4 box; other site 46234007548 G5 box; other site 46234007549 Domain of unknown function (DUF697); Region: DUF697; pfam05128 46234007550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 46234007551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 46234007552 Walker A/P-loop; other site 46234007553 ATP binding site [chemical binding]; other site 46234007554 Q-loop/lid; other site 46234007555 ABC transporter signature motif; other site 46234007556 Walker B; other site 46234007557 D-loop; other site 46234007558 H-loop/switch region; other site 46234007559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234007560 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 46234007561 FtsX-like permease family; Region: FtsX; pfam02687 46234007562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 46234007563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234007564 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234007565 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 46234007566 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 46234007567 active site 46234007568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234007569 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 46234007570 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 46234007571 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 46234007572 Malic enzyme, N-terminal domain; Region: malic; pfam00390 46234007573 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 46234007574 putative NAD(P) binding site [chemical binding]; other site 46234007575 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 46234007576 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 46234007577 putative ADP-binding pocket [chemical binding]; other site 46234007578 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 46234007579 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 46234007580 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 46234007581 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 46234007582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234007583 motif II; other site 46234007584 recombinase A; Provisional; Region: recA; PRK09354 46234007585 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 46234007586 hexamer interface [polypeptide binding]; other site 46234007587 Walker A motif; other site 46234007588 ATP binding site [chemical binding]; other site 46234007589 Walker B motif; other site 46234007590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234007591 ATP binding site [chemical binding]; other site 46234007592 putative Mg++ binding site [ion binding]; other site 46234007593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234007594 nucleotide binding region [chemical binding]; other site 46234007595 ATP-binding site [chemical binding]; other site 46234007596 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 46234007597 active site 46234007598 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 46234007599 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 46234007600 acyl-activating enzyme (AAE) consensus motif; other site 46234007601 putative AMP binding site [chemical binding]; other site 46234007602 putative active site [active] 46234007603 putative CoA binding site [chemical binding]; other site 46234007604 O-succinylbenzoate synthase; Provisional; Region: PRK02714 46234007605 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 46234007606 active site 46234007607 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 46234007608 UbiA prenyltransferase family; Region: UbiA; pfam01040 46234007609 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 46234007610 chorismate binding enzyme; Region: Chorismate_bind; cl10555 46234007611 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 46234007612 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 46234007613 putative catalytic cysteine [active] 46234007614 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007615 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007616 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007617 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007618 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007619 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007620 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 46234007621 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 46234007622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234007623 Walker A motif; other site 46234007624 ATP binding site [chemical binding]; other site 46234007625 Walker B motif; other site 46234007626 arginine finger; other site 46234007627 Gas vesicle protein; Region: Gas_vesicle; pfam00741 46234007628 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 46234007629 Gas vesicle protein K; Region: GvpK; pfam05121 46234007630 Gas vesicle protein; Region: Gas_vesicle; pfam00741 46234007631 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 46234007632 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 46234007633 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 46234007634 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234007635 P loop; other site 46234007636 Nucleotide binding site [chemical binding]; other site 46234007637 DTAP/Switch II; other site 46234007638 Switch I; other site 46234007639 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 46234007640 DTAP/Switch II; other site 46234007641 Switch I; other site 46234007642 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 46234007643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234007644 Walker A motif; other site 46234007645 ATP binding site [chemical binding]; other site 46234007646 Walker B motif; other site 46234007647 arginine finger; other site 46234007648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234007649 Walker A motif; other site 46234007650 ATP binding site [chemical binding]; other site 46234007651 Walker B motif; other site 46234007652 arginine finger; other site 46234007653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 46234007654 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234007655 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 46234007656 carotene isomerase; Region: carot_isom; TIGR02730 46234007657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234007658 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 46234007659 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 46234007660 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 46234007661 homodimer interface [polypeptide binding]; other site 46234007662 metal binding site [ion binding]; metal-binding site 46234007663 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 46234007664 homodimer interface [polypeptide binding]; other site 46234007665 active site 46234007666 putative chemical substrate binding site [chemical binding]; other site 46234007667 metal binding site [ion binding]; metal-binding site 46234007668 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 46234007669 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 46234007670 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 46234007671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234007672 ATP binding site [chemical binding]; other site 46234007673 putative Mg++ binding site [ion binding]; other site 46234007674 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 46234007675 putative active site [active] 46234007676 Fic family protein [Function unknown]; Region: COG3177 46234007677 Fic/DOC family; Region: Fic; pfam02661 46234007678 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 46234007679 HsdM N-terminal domain; Region: HsdM_N; pfam12161 46234007680 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234007681 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 46234007682 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 46234007683 FAD binding domain; Region: FAD_binding_4; pfam01565 46234007684 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 46234007685 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 46234007686 putative active site [active] 46234007687 Ycf46; Provisional; Region: ycf46; CHL00195 46234007688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234007689 Walker A motif; other site 46234007690 ATP binding site [chemical binding]; other site 46234007691 Walker B motif; other site 46234007692 arginine finger; other site 46234007693 Bacterial SH3 domain; Region: SH3_3; cl17532 46234007694 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 46234007695 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 46234007696 dimer interface [polypeptide binding]; other site 46234007697 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 46234007698 active site 46234007699 Fe binding site [ion binding]; other site 46234007700 short chain dehydrogenase; Provisional; Region: PRK07326 46234007701 classical (c) SDRs; Region: SDR_c; cd05233 46234007702 NAD(P) binding site [chemical binding]; other site 46234007703 active site 46234007704 LabA_like proteins; Region: LabA_like; cd06167 46234007705 putative metal binding site [ion binding]; other site 46234007706 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 46234007707 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 46234007708 generic binding surface II; other site 46234007709 generic binding surface I; other site 46234007710 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234007711 putative active site [active] 46234007712 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234007713 YcfA-like protein; Region: YcfA; pfam07927 46234007714 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 46234007715 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 46234007716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234007717 catalytic residue [active] 46234007718 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 46234007719 RuvA N terminal domain; Region: RuvA_N; pfam01330 46234007720 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 46234007721 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 46234007722 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 46234007723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234007724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007725 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 46234007726 structural tetrad; other site 46234007727 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234007728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234007729 structural tetrad; other site 46234007730 TIR domain; Region: TIR_2; pfam13676 46234007731 CHAT domain; Region: CHAT; pfam12770 46234007732 AAA ATPase domain; Region: AAA_16; pfam13191 46234007733 Walker A motif; other site 46234007734 ATP binding site [chemical binding]; other site 46234007735 Walker B motif; other site 46234007736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007737 binding surface 46234007738 TPR repeat; Region: TPR_11; pfam13414 46234007739 TPR motif; other site 46234007740 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234007741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234007742 binding surface 46234007743 TPR motif; other site 46234007744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234007745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234007746 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 46234007747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234007748 substrate binding pocket [chemical binding]; other site 46234007749 membrane-bound complex binding site; other site 46234007750 hinge residues; other site 46234007751 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234007752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007753 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234007754 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 46234007755 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 46234007756 NADH(P)-binding; Region: NAD_binding_10; pfam13460 46234007757 NAD(P) binding site [chemical binding]; other site 46234007758 putative active site [active] 46234007759 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234007760 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234007761 active site 46234007762 ATP binding site [chemical binding]; other site 46234007763 substrate binding site [chemical binding]; other site 46234007764 activation loop (A-loop); other site 46234007765 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234007766 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234007767 acetolactate synthase; Reviewed; Region: PRK08322 46234007768 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 46234007769 PYR/PP interface [polypeptide binding]; other site 46234007770 dimer interface [polypeptide binding]; other site 46234007771 TPP binding site [chemical binding]; other site 46234007772 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 46234007773 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 46234007774 TPP-binding site [chemical binding]; other site 46234007775 dimer interface [polypeptide binding]; other site 46234007776 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 46234007777 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 46234007778 NAD(P) binding site [chemical binding]; other site 46234007779 catalytic residues [active] 46234007780 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 46234007781 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 46234007782 GTP/Mg2+ binding site [chemical binding]; other site 46234007783 G4 box; other site 46234007784 G5 box; other site 46234007785 G1 box; other site 46234007786 Switch I region; other site 46234007787 G2 box; other site 46234007788 G3 box; other site 46234007789 Switch II region; other site 46234007790 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 46234007791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 46234007792 active site 46234007793 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234007794 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234007795 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234007796 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 46234007797 AMP binding site [chemical binding]; other site 46234007798 metal binding site [ion binding]; metal-binding site 46234007799 active site 46234007800 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 46234007801 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 46234007802 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 46234007803 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 46234007804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234007805 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 46234007806 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 46234007807 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 46234007808 Walker A motif; other site 46234007809 ATP binding site [chemical binding]; other site 46234007810 Walker B motif; other site 46234007811 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 46234007812 tetramer interface [polypeptide binding]; other site 46234007813 dimer interface [polypeptide binding]; other site 46234007814 Transposase IS200 like; Region: Y1_Tnp; cl00848 46234007815 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 46234007816 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 46234007817 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 46234007818 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 46234007819 putative ligand binding site [chemical binding]; other site 46234007820 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 46234007821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234007822 motif II; other site 46234007823 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 46234007824 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 46234007825 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 46234007826 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 46234007827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234007828 Coenzyme A binding pocket [chemical binding]; other site 46234007829 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234007830 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 46234007831 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 46234007832 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 46234007833 protein binding site [polypeptide binding]; other site 46234007834 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 46234007835 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 46234007836 Protein of unknown function (DUF423); Region: DUF423; pfam04241 46234007837 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 46234007838 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 46234007839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234007840 ATP binding site [chemical binding]; other site 46234007841 putative Mg++ binding site [ion binding]; other site 46234007842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234007843 nucleotide binding region [chemical binding]; other site 46234007844 ATP-binding site [chemical binding]; other site 46234007845 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 46234007846 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 46234007847 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 46234007848 Catalytic site [active] 46234007849 ornithine carbamoyltransferase; Provisional; Region: PRK00779 46234007850 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 46234007851 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 46234007852 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234007853 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234007854 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234007855 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234007856 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 46234007857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 46234007858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234007859 non-specific DNA binding site [nucleotide binding]; other site 46234007860 salt bridge; other site 46234007861 sequence-specific DNA binding site [nucleotide binding]; other site 46234007862 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234007863 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234007864 Predicted ATPase [General function prediction only]; Region: COG4637 46234007865 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 46234007866 Nuclease-related domain; Region: NERD; pfam08378 46234007867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234007868 active site 46234007869 ATP binding site [chemical binding]; other site 46234007870 substrate binding site [chemical binding]; other site 46234007871 activation loop (A-loop); other site 46234007872 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234007873 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234007874 active site 46234007875 ATP binding site [chemical binding]; other site 46234007876 substrate binding site [chemical binding]; other site 46234007877 activation loop (A-loop); other site 46234007878 AAA-like domain; Region: AAA_10; pfam12846 46234007879 Zonular occludens toxin (Zot); Region: Zot; cl17485 46234007880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234007881 active site 46234007882 phosphorylation site [posttranslational modification] 46234007883 intermolecular recognition site; other site 46234007884 Radical SAM superfamily; Region: Radical_SAM; pfam04055 46234007885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234007886 FeS/SAM binding site; other site 46234007887 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234007888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 46234007889 active site 46234007890 phosphorylation site [posttranslational modification] 46234007891 intermolecular recognition site; other site 46234007892 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 46234007893 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 46234007894 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 46234007895 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 46234007896 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234007897 oligomeric interface; other site 46234007898 putative active site [active] 46234007899 homodimer interface [polypeptide binding]; other site 46234007900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 46234007901 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 46234007902 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 46234007903 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 46234007904 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 46234007905 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 46234007906 active site 46234007907 catalytic site [active] 46234007908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234007909 S-adenosylmethionine binding site [chemical binding]; other site 46234007910 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 46234007911 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 46234007912 Ligand binding site; other site 46234007913 Putative Catalytic site; other site 46234007914 DXD motif; other site 46234007915 Predicted membrane protein [Function unknown]; Region: COG2246 46234007916 GtrA-like protein; Region: GtrA; pfam04138 46234007917 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 46234007918 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 46234007919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234007920 acyl-activating enzyme (AAE) consensus motif; other site 46234007921 active site 46234007922 AMP binding site [chemical binding]; other site 46234007923 CoA binding site [chemical binding]; other site 46234007924 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 46234007925 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 46234007926 Putative esterase; Region: Esterase; pfam00756 46234007927 H+ Antiporter protein; Region: 2A0121; TIGR00900 46234007928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234007929 putative substrate translocation pore; other site 46234007930 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 46234007931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234007932 NAD(P) binding site [chemical binding]; other site 46234007933 active site 46234007934 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 46234007935 Condensation domain; Region: Condensation; pfam00668 46234007936 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234007937 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234007938 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007939 acyl-activating enzyme (AAE) consensus motif; other site 46234007940 AMP binding site [chemical binding]; other site 46234007941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007942 Condensation domain; Region: Condensation; pfam00668 46234007943 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234007944 Condensation domain; Region: Condensation; pfam00668 46234007945 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007946 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234007947 acyl-activating enzyme (AAE) consensus motif; other site 46234007948 AMP binding site [chemical binding]; other site 46234007949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007950 Condensation domain; Region: Condensation; pfam00668 46234007951 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234007952 peptide synthase; Provisional; Region: PRK12467 46234007953 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007954 acyl-activating enzyme (AAE) consensus motif; other site 46234007955 AMP binding site [chemical binding]; other site 46234007956 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007958 acyl-activating enzyme (AAE) consensus motif; other site 46234007959 AMP binding site [chemical binding]; other site 46234007960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007961 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 46234007962 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 46234007963 acyl-activating enzyme (AAE) consensus motif; other site 46234007964 AMP binding site [chemical binding]; other site 46234007965 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007966 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234007967 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 46234007968 NAD binding site [chemical binding]; other site 46234007969 homotetramer interface [polypeptide binding]; other site 46234007970 homodimer interface [polypeptide binding]; other site 46234007971 active site 46234007972 substrate binding site [chemical binding]; other site 46234007973 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 46234007974 glycosyltransferase, MGT family; Region: MGT; TIGR01426 46234007975 active site 46234007976 TDP-binding site; other site 46234007977 acceptor substrate-binding pocket; other site 46234007978 homodimer interface [polypeptide binding]; other site 46234007979 Cupin-like domain; Region: Cupin_8; pfam13621 46234007980 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 46234007981 MbtH-like protein; Region: MbtH; cl01279 46234007982 Condensation domain; Region: Condensation; pfam00668 46234007983 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007984 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234007985 acyl-activating enzyme (AAE) consensus motif; other site 46234007986 AMP binding site [chemical binding]; other site 46234007987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007988 Condensation domain; Region: Condensation; pfam00668 46234007989 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234007990 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 46234007991 acyl-activating enzyme (AAE) consensus motif; other site 46234007992 AMP binding site [chemical binding]; other site 46234007993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234007994 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 46234007995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234007996 active site 46234007997 Condensation domain; Region: Condensation; pfam00668 46234007998 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234007999 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234008000 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234008001 acyl-activating enzyme (AAE) consensus motif; other site 46234008002 AMP binding site [chemical binding]; other site 46234008003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234008004 S-adenosylmethionine binding site [chemical binding]; other site 46234008005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 46234008006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234008007 Condensation domain; Region: Condensation; pfam00668 46234008008 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 46234008009 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 46234008010 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 46234008011 acyl-activating enzyme (AAE) consensus motif; other site 46234008012 AMP binding site [chemical binding]; other site 46234008013 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234008014 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 46234008015 H+ Antiporter protein; Region: 2A0121; TIGR00900 46234008016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234008017 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234008018 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234008019 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 46234008020 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 46234008021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234008022 catalytic residue [active] 46234008023 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 46234008024 FeS assembly protein SufD; Region: sufD; TIGR01981 46234008025 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 46234008026 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 46234008027 Walker A/P-loop; other site 46234008028 ATP binding site [chemical binding]; other site 46234008029 Q-loop/lid; other site 46234008030 ABC transporter signature motif; other site 46234008031 Walker B; other site 46234008032 D-loop; other site 46234008033 H-loop/switch region; other site 46234008034 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 46234008035 putative ABC transporter; Region: ycf24; CHL00085 46234008036 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 46234008037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 46234008038 putative DNA binding site [nucleotide binding]; other site 46234008039 putative Zn2+ binding site [ion binding]; other site 46234008040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234008041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008042 TPR motif; other site 46234008043 binding surface 46234008044 CHAT domain; Region: CHAT; pfam12770 46234008045 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234008046 putative active site [active] 46234008047 PemK-like protein; Region: PemK; pfam02452 46234008048 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234008049 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 46234008050 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234008051 putative active site [active] 46234008052 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 46234008053 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 46234008054 Sulfate transporter family; Region: Sulfate_transp; pfam00916 46234008055 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 46234008056 Uncharacterized conserved protein [Function unknown]; Region: COG0393 46234008057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008058 binding surface 46234008059 TPR repeat; Region: TPR_11; pfam13414 46234008060 TPR motif; other site 46234008061 TPR repeat; Region: TPR_11; pfam13414 46234008062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008063 binding surface 46234008064 TPR motif; other site 46234008065 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 46234008066 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 46234008067 putative substrate binding site [chemical binding]; other site 46234008068 putative ATP binding site [chemical binding]; other site 46234008069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234008070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234008071 DNA binding residues [nucleotide binding] 46234008072 dimerization interface [polypeptide binding]; other site 46234008073 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 46234008074 L-aspartate oxidase; Provisional; Region: PRK06175 46234008075 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 46234008076 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008077 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234008078 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234008079 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008080 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234008081 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008083 binding surface 46234008084 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234008085 TPR motif; other site 46234008086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008087 binding surface 46234008088 TPR motif; other site 46234008089 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234008090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008091 TPR motif; other site 46234008092 binding surface 46234008093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008094 binding surface 46234008095 TPR motif; other site 46234008096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008097 TPR motif; other site 46234008098 binding surface 46234008099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008100 binding surface 46234008101 TPR repeat; Region: TPR_11; pfam13414 46234008102 TPR motif; other site 46234008103 TPR repeat; Region: TPR_11; pfam13414 46234008104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008105 TPR motif; other site 46234008106 binding surface 46234008107 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234008108 Tetratricopeptide repeat; Region: TPR_1; pfam00515 46234008109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008110 TPR motif; other site 46234008111 binding surface 46234008112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008113 binding surface 46234008114 TPR motif; other site 46234008115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008116 binding surface 46234008117 TPR motif; other site 46234008118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234008119 Probable transposase; Region: OrfB_IS605; pfam01385 46234008120 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234008121 Bacterial Ig-like domain; Region: Big_5; pfam13205 46234008122 TIGR03943 family protein; Region: TIGR03943 46234008123 Predicted permeases [General function prediction only]; Region: COG0701 46234008124 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008125 GUN4-like; Region: GUN4; pfam05419 46234008126 Uncharacterized conserved protein [Function unknown]; Region: COG2006 46234008127 Domain of unknown function (DUF362); Region: DUF362; pfam04015 46234008128 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 46234008129 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 46234008130 active site 46234008131 catalytic triad [active] 46234008132 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 46234008133 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 46234008134 dimer interface [polypeptide binding]; other site 46234008135 catalytic residues [active] 46234008136 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 46234008137 UreF; Region: UreF; pfam01730 46234008138 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234008139 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 46234008140 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 46234008141 Uncharacterized conserved protein [Function unknown]; Region: COG0327 46234008142 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 46234008143 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 46234008144 arsenical-resistance protein; Region: acr3; TIGR00832 46234008145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234008146 putative substrate translocation pore; other site 46234008147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 46234008148 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 46234008149 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 46234008150 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 46234008151 PBP superfamily domain; Region: PBP_like_2; cl17296 46234008152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234008153 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234008154 Probable transposase; Region: OrfB_IS605; pfam01385 46234008155 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234008156 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 46234008157 GTP/Mg2+ binding site [chemical binding]; other site 46234008158 G4 box; other site 46234008159 G5 box; other site 46234008160 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 46234008161 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 46234008162 G1 box; other site 46234008163 G1 box; other site 46234008164 GTP/Mg2+ binding site [chemical binding]; other site 46234008165 G3 box; other site 46234008166 Switch II region; other site 46234008167 G4 box; other site 46234008168 G5 box; other site 46234008169 Domain of unknown function (DUF697); Region: DUF697; pfam05128 46234008170 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 46234008171 substrate binding pocket [chemical binding]; other site 46234008172 substrate-Mg2+ binding site; other site 46234008173 aspartate-rich region 1; other site 46234008174 aspartate-rich region 2; other site 46234008175 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 46234008176 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 46234008177 B12 binding site [chemical binding]; other site 46234008178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234008179 FeS/SAM binding site; other site 46234008180 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 46234008181 putative active site [active] 46234008182 YdjC motif; other site 46234008183 Mg binding site [ion binding]; other site 46234008184 putative homodimer interface [polypeptide binding]; other site 46234008185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234008186 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234008187 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234008188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234008189 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234008190 HSP70 interaction site [polypeptide binding]; other site 46234008191 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 46234008192 AAA ATPase domain; Region: AAA_16; pfam13191 46234008193 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 46234008194 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 46234008195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234008196 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234008197 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 46234008198 Walker A/P-loop; other site 46234008199 ATP binding site [chemical binding]; other site 46234008200 Q-loop/lid; other site 46234008201 ABC transporter signature motif; other site 46234008202 Walker B; other site 46234008203 D-loop; other site 46234008204 H-loop/switch region; other site 46234008205 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 46234008206 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 46234008207 ligand binding site; other site 46234008208 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 46234008209 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 46234008210 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 46234008211 S-adenosylmethionine binding site [chemical binding]; other site 46234008212 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 46234008213 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 46234008214 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 46234008215 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 46234008216 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 46234008217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234008218 active site 46234008219 phosphorylation site [posttranslational modification] 46234008220 intermolecular recognition site; other site 46234008221 dimerization interface [polypeptide binding]; other site 46234008222 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 46234008223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 46234008224 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 46234008225 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 46234008226 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 46234008227 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 46234008228 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234008229 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 46234008230 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 46234008231 inhibitor-cofactor binding pocket; inhibition site 46234008232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008233 catalytic residue [active] 46234008234 WbqC-like protein family; Region: WbqC; pfam08889 46234008235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 46234008236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234008237 Coenzyme A binding pocket [chemical binding]; other site 46234008238 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 46234008239 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234008240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234008241 active site 46234008242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234008243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234008244 Walker A/P-loop; other site 46234008245 ATP binding site [chemical binding]; other site 46234008246 Q-loop/lid; other site 46234008247 ABC transporter signature motif; other site 46234008248 Walker B; other site 46234008249 D-loop; other site 46234008250 H-loop/switch region; other site 46234008251 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 46234008252 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234008253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234008254 active site 46234008255 Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins...; Region: Sina; cd03829 46234008256 substrate binding site [chemical binding]; other site 46234008257 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234008258 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 46234008259 active site 46234008260 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234008261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008262 Core-2/I-Branching enzyme; Region: Branch; pfam02485 46234008263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008264 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234008265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008266 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234008267 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234008268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 46234008269 active site 46234008270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234008272 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 46234008273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008274 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234008275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008276 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 46234008277 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 46234008278 active site 46234008279 ribulose/triose binding site [chemical binding]; other site 46234008280 phosphate binding site [ion binding]; other site 46234008281 substrate (anthranilate) binding pocket [chemical binding]; other site 46234008282 product (indole) binding pocket [chemical binding]; other site 46234008283 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 46234008284 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 46234008285 NAD binding site [chemical binding]; other site 46234008286 substrate binding site [chemical binding]; other site 46234008287 homodimer interface [polypeptide binding]; other site 46234008288 active site 46234008289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008290 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234008291 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 46234008292 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 46234008293 Uncharacterized conserved protein [Function unknown]; Region: COG3937 46234008294 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 46234008295 Subunit I/III interface [polypeptide binding]; other site 46234008296 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 46234008297 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 46234008298 D-pathway; other site 46234008299 Putative ubiquinol binding site [chemical binding]; other site 46234008300 Low-spin heme (heme b) binding site [chemical binding]; other site 46234008301 Putative water exit pathway; other site 46234008302 Binuclear center (heme o3/CuB) [ion binding]; other site 46234008303 K-pathway; other site 46234008304 Putative proton exit pathway; other site 46234008305 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 46234008306 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 46234008307 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 46234008308 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 46234008309 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 46234008310 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 46234008311 UbiA prenyltransferase family; Region: UbiA; pfam01040 46234008312 Uncharacterized conserved protein [Function unknown]; Region: COG1543 46234008313 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 46234008314 active site 46234008315 substrate binding site [chemical binding]; other site 46234008316 catalytic site [active] 46234008317 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 46234008318 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 46234008319 active site 46234008320 NAD binding site [chemical binding]; other site 46234008321 metal binding site [ion binding]; metal-binding site 46234008322 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 46234008323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234008324 S-adenosylmethionine binding site [chemical binding]; other site 46234008325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 46234008326 hypothetical protein; Provisional; Region: PRK06849 46234008327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234008328 ATP-grasp domain; Region: ATP-grasp_4; cl17255 46234008329 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 46234008330 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 46234008331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 46234008332 GTPase RsgA; Reviewed; Region: PRK12289 46234008333 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 46234008334 RNA binding site [nucleotide binding]; other site 46234008335 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 46234008336 GTPase/Zn-binding domain interface [polypeptide binding]; other site 46234008337 GTP/Mg2+ binding site [chemical binding]; other site 46234008338 G4 box; other site 46234008339 G5 box; other site 46234008340 G1 box; other site 46234008341 Switch I region; other site 46234008342 G2 box; other site 46234008343 G3 box; other site 46234008344 Switch II region; other site 46234008345 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 46234008346 CPxP motif; other site 46234008347 chaperone protein DnaJ; Provisional; Region: PRK14293 46234008348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234008349 HSP70 interaction site [polypeptide binding]; other site 46234008350 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 46234008351 Zn binding sites [ion binding]; other site 46234008352 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 46234008353 dimer interface [polypeptide binding]; other site 46234008354 molecular chaperone DnaK; Provisional; Region: PRK13411 46234008355 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 46234008356 nucleotide binding site [chemical binding]; other site 46234008357 NEF interaction site [polypeptide binding]; other site 46234008358 SBD interface [polypeptide binding]; other site 46234008359 GrpE; Region: GrpE; pfam01025 46234008360 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 46234008361 dimer interface [polypeptide binding]; other site 46234008362 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 46234008363 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 46234008364 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 46234008365 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 46234008366 Walker A motif; other site 46234008367 ATP binding site [chemical binding]; other site 46234008368 Walker B motif; other site 46234008369 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 46234008370 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 46234008371 Walker A motif; other site 46234008372 ATP binding site [chemical binding]; other site 46234008373 Walker B motif; other site 46234008374 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 46234008375 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 46234008376 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 46234008377 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 46234008378 NAD(P) binding pocket [chemical binding]; other site 46234008379 DNA polymerase I; Provisional; Region: PRK05755 46234008380 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 46234008381 active site 46234008382 metal binding site 1 [ion binding]; metal-binding site 46234008383 putative 5' ssDNA interaction site; other site 46234008384 metal binding site 3; metal-binding site 46234008385 metal binding site 2 [ion binding]; metal-binding site 46234008386 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 46234008387 putative DNA binding site [nucleotide binding]; other site 46234008388 putative metal binding site [ion binding]; other site 46234008389 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 46234008390 active site 46234008391 catalytic site [active] 46234008392 substrate binding site [chemical binding]; other site 46234008393 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 46234008394 active site 46234008395 DNA binding site [nucleotide binding] 46234008396 catalytic site [active] 46234008397 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 46234008398 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 46234008399 FMN binding site [chemical binding]; other site 46234008400 active site 46234008401 catalytic residues [active] 46234008402 substrate binding site [chemical binding]; other site 46234008403 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 46234008404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234008405 active site 46234008406 motif I; other site 46234008407 motif II; other site 46234008408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 46234008409 DALR anticodon binding domain; Region: DALR_1; smart00836 46234008410 anticodon binding site; other site 46234008411 tRNA binding surface [nucleotide binding]; other site 46234008412 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 46234008413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 46234008414 putative switch regulator; other site 46234008415 non-specific DNA interactions [nucleotide binding]; other site 46234008416 DNA binding site [nucleotide binding] 46234008417 sequence specific DNA binding site [nucleotide binding]; other site 46234008418 putative cAMP binding site [chemical binding]; other site 46234008419 PBP superfamily domain; Region: PBP_like_2; pfam12849 46234008420 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 46234008421 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 46234008422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 46234008423 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 46234008424 putative dimerization interface [polypeptide binding]; other site 46234008425 Predicted membrane protein [Function unknown]; Region: COG4094 46234008426 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234008427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234008428 catalytic residues [active] 46234008429 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 46234008430 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 46234008431 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234008432 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 46234008433 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234008434 putative active site [active] 46234008435 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 46234008436 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234008437 DNA methylase; Region: N6_N4_Mtase; pfam01555 46234008438 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234008439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234008440 S-adenosylmethionine binding site [chemical binding]; other site 46234008441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 46234008442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 46234008443 active site 46234008444 catalytic tetrad [active] 46234008445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234008446 H+ Antiporter protein; Region: 2A0121; TIGR00900 46234008447 putative substrate translocation pore; other site 46234008448 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 46234008449 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 46234008450 PYR/PP interface [polypeptide binding]; other site 46234008451 dimer interface [polypeptide binding]; other site 46234008452 TPP binding site [chemical binding]; other site 46234008453 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 46234008454 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 46234008455 TPP-binding site [chemical binding]; other site 46234008456 dimer interface [polypeptide binding]; other site 46234008457 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 46234008458 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 46234008459 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 46234008460 putative active site [active] 46234008461 RRXRR protein; Region: RRXRR; pfam14239 46234008462 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234008463 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234008464 active site 46234008465 TPR repeat; Region: TPR_11; pfam13414 46234008466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008467 binding surface 46234008468 TPR motif; other site 46234008469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008470 binding surface 46234008471 TPR repeat; Region: TPR_11; pfam13414 46234008472 TPR motif; other site 46234008473 TPR repeat; Region: TPR_11; pfam13414 46234008474 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 46234008475 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 46234008476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234008477 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 46234008478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234008479 DNA binding residues [nucleotide binding] 46234008480 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 46234008481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234008482 Mg2+ binding site [ion binding]; other site 46234008483 G-X-G motif; other site 46234008484 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 46234008485 anchoring element; other site 46234008486 dimer interface [polypeptide binding]; other site 46234008487 ATP binding site [chemical binding]; other site 46234008488 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234008489 protein-splicing catalytic site; other site 46234008490 thioester formation/cholesterol transfer; other site 46234008491 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 46234008492 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234008493 protein-splicing catalytic site; other site 46234008494 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 46234008495 active site 46234008496 putative metal-binding site [ion binding]; other site 46234008497 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 46234008498 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 46234008499 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 46234008500 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 46234008501 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 46234008502 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 46234008503 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 46234008504 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 46234008505 G-X-X-G motif; other site 46234008506 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 46234008507 RxxxH motif; other site 46234008508 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 46234008509 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 46234008510 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 46234008511 Bacterial PH domain; Region: DUF304; pfam03703 46234008512 ribonuclease P; Reviewed; Region: rnpA; PRK03031 46234008513 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 46234008514 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 46234008515 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 46234008516 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 46234008517 ligand binding site [chemical binding]; other site 46234008518 homodimer interface [polypeptide binding]; other site 46234008519 NAD(P) binding site [chemical binding]; other site 46234008520 trimer interface B [polypeptide binding]; other site 46234008521 trimer interface A [polypeptide binding]; other site 46234008522 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 46234008523 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 46234008524 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 46234008525 Protein of unknown function DUF91; Region: DUF91; cl00709 46234008526 PemK-like protein; Region: PemK; cl00995 46234008527 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 46234008528 YcfA-like protein; Region: YcfA; pfam07927 46234008529 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234008530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234008531 HSP70 interaction site [polypeptide binding]; other site 46234008532 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 46234008533 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 46234008534 dimer interface [polypeptide binding]; other site 46234008535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008536 catalytic residue [active] 46234008537 Predicted transcriptional regulator [Transcription]; Region: COG1959 46234008538 Transcriptional regulator; Region: Rrf2; pfam02082 46234008539 S-layer homology domain; Region: SLH; pfam00395 46234008540 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 46234008541 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 46234008542 D1 interface; other site 46234008543 chlorophyll binding site; other site 46234008544 pheophytin binding site; other site 46234008545 beta carotene binding site; other site 46234008546 cytochrome b559 beta interface; other site 46234008547 quinone binding site; other site 46234008548 cytochrome b559 alpha interface; other site 46234008549 protein J interface; other site 46234008550 protein H interface; other site 46234008551 protein X interface; other site 46234008552 core light harvesting protein interface; other site 46234008553 protein L interface; other site 46234008554 CP43 interface; other site 46234008555 protein T interface; other site 46234008556 Fe binding site [ion binding]; other site 46234008557 protein M interface; other site 46234008558 Mn-stabilizing polypeptide interface; other site 46234008559 bromide binding site; other site 46234008560 cytochrome c-550 interface; other site 46234008561 hypothetical protein; Provisional; Region: PRK13683 46234008562 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234008563 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 46234008564 Walker A/P-loop; other site 46234008565 ATP binding site [chemical binding]; other site 46234008566 Q-loop/lid; other site 46234008567 ABC transporter signature motif; other site 46234008568 Walker B; other site 46234008569 D-loop; other site 46234008570 H-loop/switch region; other site 46234008571 YacP-like NYN domain; Region: NYN_YacP; cl01491 46234008572 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 46234008573 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 46234008574 N-terminal plug; other site 46234008575 ligand-binding site [chemical binding]; other site 46234008576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234008577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008578 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 46234008579 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 46234008580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 46234008581 active site 46234008582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 46234008583 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 46234008584 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 46234008585 active site 46234008586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234008587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234008588 NAD(P) binding site [chemical binding]; other site 46234008589 active site 46234008590 DevC protein; Region: devC; TIGR01185 46234008591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234008592 FtsX-like permease family; Region: FtsX; pfam02687 46234008593 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 46234008594 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234008595 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234008596 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234008597 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 46234008598 active site 46234008599 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 46234008600 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234008601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 46234008602 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 46234008603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234008604 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 46234008605 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 46234008606 putative NADP binding site [chemical binding]; other site 46234008607 active site 46234008608 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234008609 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 46234008610 active site 46234008611 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 46234008612 active site 46234008613 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 46234008614 Acyl transferase domain; Region: Acyl_transf_1; cl08282 46234008615 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 46234008616 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 46234008617 FMN binding site [chemical binding]; other site 46234008618 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 46234008619 substrate binding site [chemical binding]; other site 46234008620 putative catalytic residue [active] 46234008621 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 46234008622 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 46234008623 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 46234008624 putative NAD(P) binding site [chemical binding]; other site 46234008625 active site 46234008626 putative substrate binding site [chemical binding]; other site 46234008627 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 46234008628 classical (c) SDRs; Region: SDR_c; cd05233 46234008629 NAD(P) binding site [chemical binding]; other site 46234008630 active site 46234008631 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 46234008632 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 46234008633 DNA binding site [nucleotide binding] 46234008634 catalytic residue [active] 46234008635 H2TH interface [polypeptide binding]; other site 46234008636 putative catalytic residues [active] 46234008637 turnover-facilitating residue; other site 46234008638 intercalation triad [nucleotide binding]; other site 46234008639 8OG recognition residue [nucleotide binding]; other site 46234008640 putative reading head residues; other site 46234008641 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 46234008642 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 46234008643 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 46234008644 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 46234008645 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 46234008646 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 46234008647 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 46234008648 Mg++ binding site [ion binding]; other site 46234008649 putative catalytic motif [active] 46234008650 putative substrate binding site [chemical binding]; other site 46234008651 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234008652 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234008653 active site 46234008654 ATP binding site [chemical binding]; other site 46234008655 substrate binding site [chemical binding]; other site 46234008656 activation loop (A-loop); other site 46234008657 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234008658 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234008660 TPR repeat; Region: TPR_11; pfam13414 46234008661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008662 binding surface 46234008663 TPR motif; other site 46234008664 TPR repeat; Region: TPR_11; pfam13414 46234008665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008666 binding surface 46234008667 TPR motif; other site 46234008668 TPR repeat; Region: TPR_11; pfam13414 46234008669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008670 binding surface 46234008671 TPR motif; other site 46234008672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008673 binding surface 46234008674 TPR motif; other site 46234008675 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234008676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008677 binding surface 46234008678 TPR motif; other site 46234008679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008680 binding surface 46234008681 TPR motif; other site 46234008682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008683 binding surface 46234008684 TPR motif; other site 46234008685 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234008686 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 46234008687 MPT binding site; other site 46234008688 trimer interface [polypeptide binding]; other site 46234008689 Psb28 protein; Region: Psb28; cl04326 46234008690 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 46234008691 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 46234008692 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 46234008693 active site 46234008694 dimer interface [polypeptide binding]; other site 46234008695 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 46234008696 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 46234008697 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 46234008698 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 46234008699 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 46234008700 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234008701 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 46234008702 NAD binding site [chemical binding]; other site 46234008703 putative substrate binding site 2 [chemical binding]; other site 46234008704 putative substrate binding site 1 [chemical binding]; other site 46234008705 active site 46234008706 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234008707 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234008708 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 46234008709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234008710 motif II; other site 46234008711 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 46234008712 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 46234008713 HIGH motif; other site 46234008714 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 46234008715 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 46234008716 active site 46234008717 KMSKS motif; other site 46234008718 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 46234008719 tRNA binding surface [nucleotide binding]; other site 46234008720 anticodon binding site; other site 46234008721 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 46234008722 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 46234008723 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 46234008724 putative active site [active] 46234008725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234008726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234008727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234008728 Walker A/P-loop; other site 46234008729 ATP binding site [chemical binding]; other site 46234008730 Q-loop/lid; other site 46234008731 ABC transporter signature motif; other site 46234008732 Walker B; other site 46234008733 D-loop; other site 46234008734 H-loop/switch region; other site 46234008735 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 46234008736 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234008737 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234008738 putative acyl-acceptor binding pocket; other site 46234008739 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 46234008740 Phosphate acyltransferases; Region: PlsC; smart00563 46234008741 Protein of unknown function (DUF938); Region: DUF938; pfam06080 46234008742 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 46234008743 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 46234008744 active site residue [active] 46234008745 glycine dehydrogenase; Provisional; Region: PRK05367 46234008746 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 46234008747 tetramer interface [polypeptide binding]; other site 46234008748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008749 catalytic residue [active] 46234008750 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 46234008751 tetramer interface [polypeptide binding]; other site 46234008752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008753 catalytic residue [active] 46234008754 GxxExxY protein; Region: GxxExxY; TIGR04256 46234008755 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 46234008756 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234008757 oligomeric interface; other site 46234008758 putative active site [active] 46234008759 homodimer interface [polypeptide binding]; other site 46234008760 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 46234008761 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 46234008762 L-aspartate oxidase; Provisional; Region: PRK07395 46234008763 L-aspartate oxidase; Provisional; Region: PRK06175 46234008764 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 46234008765 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 46234008766 AAA ATPase domain; Region: AAA_16; pfam13191 46234008767 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 46234008768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234008769 binding surface 46234008770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234008771 TPR motif; other site 46234008772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234008773 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 46234008774 catalytic triad [active] 46234008775 putative active site [active] 46234008776 threonine synthase; Reviewed; Region: PRK06721 46234008777 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 46234008778 homodimer interface [polypeptide binding]; other site 46234008779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008780 catalytic residue [active] 46234008781 agmatinase; Region: agmatinase; TIGR01230 46234008782 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 46234008783 putative active site [active] 46234008784 Mn binding site [ion binding]; other site 46234008785 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 46234008786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234008787 S-adenosylmethionine binding site [chemical binding]; other site 46234008788 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 46234008789 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 46234008790 ligand binding site [chemical binding]; other site 46234008791 NAD binding site [chemical binding]; other site 46234008792 dimerization interface [polypeptide binding]; other site 46234008793 catalytic site [active] 46234008794 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 46234008795 putative L-serine binding site [chemical binding]; other site 46234008796 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 46234008797 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 46234008798 dimer interface [polypeptide binding]; other site 46234008799 tetramer interface [polypeptide binding]; other site 46234008800 PYR/PP interface [polypeptide binding]; other site 46234008801 TPP binding site [chemical binding]; other site 46234008802 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 46234008803 TPP-binding site; other site 46234008804 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 46234008805 homooctamer interface [polypeptide binding]; other site 46234008806 active site 46234008807 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 46234008808 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 46234008809 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234008810 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 46234008811 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 46234008812 CoenzymeA binding site [chemical binding]; other site 46234008813 subunit interaction site [polypeptide binding]; other site 46234008814 PHB binding site; other site 46234008815 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 46234008816 DEAD-like helicases superfamily; Region: DEXDc; smart00487 46234008817 ATP binding site [chemical binding]; other site 46234008818 Mg++ binding site [ion binding]; other site 46234008819 motif III; other site 46234008820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234008821 nucleotide binding region [chemical binding]; other site 46234008822 ATP-binding site [chemical binding]; other site 46234008823 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 46234008824 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 46234008825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234008826 FeS/SAM binding site; other site 46234008827 TRAM domain; Region: TRAM; cl01282 46234008828 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 46234008829 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 46234008830 substrate binding site [chemical binding]; other site 46234008831 putative active site [active] 46234008832 redox center [active] 46234008833 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 46234008834 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 46234008835 Clp amino terminal domain; Region: Clp_N; pfam02861 46234008836 Clp amino terminal domain; Region: Clp_N; pfam02861 46234008837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234008838 Walker A motif; other site 46234008839 ATP binding site [chemical binding]; other site 46234008840 Walker B motif; other site 46234008841 arginine finger; other site 46234008842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234008843 Walker A motif; other site 46234008844 ATP binding site [chemical binding]; other site 46234008845 Walker B motif; other site 46234008846 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 46234008847 Domain of unknown function DUF11; Region: DUF11; pfam01345 46234008848 Domain of unknown function DUF11; Region: DUF11; pfam01345 46234008849 Domain of unknown function DUF11; Region: DUF11; pfam01345 46234008850 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234008851 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234008852 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 46234008853 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 46234008854 hydrophobic ligand binding site; other site 46234008855 Rubredoxin [Energy production and conversion]; Region: COG1773 46234008856 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 46234008857 iron binding site [ion binding]; other site 46234008858 flavoprotein, HI0933 family; Region: TIGR00275 46234008859 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 46234008860 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 46234008861 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 46234008862 trimer interface [polypeptide binding]; other site 46234008863 active site 46234008864 UDP-GlcNAc binding site [chemical binding]; other site 46234008865 lipid binding site [chemical binding]; lipid-binding site 46234008866 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 46234008867 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 46234008868 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 46234008869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234008870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234008871 S-adenosylmethionine binding site [chemical binding]; other site 46234008872 ferrochelatase; Reviewed; Region: hemH; PRK00035 46234008873 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 46234008874 C-terminal domain interface [polypeptide binding]; other site 46234008875 active site 46234008876 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 46234008877 active site 46234008878 N-terminal domain interface [polypeptide binding]; other site 46234008879 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 46234008880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234008881 Probable transposase; Region: OrfB_IS605; pfam01385 46234008882 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234008883 adenylosuccinate lyase; Provisional; Region: PRK07380 46234008884 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 46234008885 tetramer interface [polypeptide binding]; other site 46234008886 active site 46234008887 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 46234008888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 46234008889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234008890 dimer interface [polypeptide binding]; other site 46234008891 phosphorylation site [posttranslational modification] 46234008892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234008893 ATP binding site [chemical binding]; other site 46234008894 Mg2+ binding site [ion binding]; other site 46234008895 G-X-G motif; other site 46234008896 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 46234008897 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 46234008898 Domain of unknown function DUF59; Region: DUF59; pfam01883 46234008899 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 46234008900 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 46234008901 CAAX protease self-immunity; Region: Abi; pfam02517 46234008902 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 46234008903 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 46234008904 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234008905 catalytic loop [active] 46234008906 iron binding site [ion binding]; other site 46234008907 GDYXXLXY protein; Region: GDYXXLXY; cl02066 46234008908 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 46234008909 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 46234008910 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 46234008911 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 46234008912 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 46234008913 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 46234008914 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234008915 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234008916 phosphopeptide binding site; other site 46234008917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234008918 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234008919 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 46234008920 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 46234008921 metal binding site [ion binding]; metal-binding site 46234008922 active site 46234008923 I-site; other site 46234008924 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 46234008925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 46234008926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234008927 Walker A/P-loop; other site 46234008928 ATP binding site [chemical binding]; other site 46234008929 Q-loop/lid; other site 46234008930 ABC transporter signature motif; other site 46234008931 Walker B; other site 46234008932 D-loop; other site 46234008933 H-loop/switch region; other site 46234008934 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 46234008935 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 46234008936 hypothetical protein; Provisional; Region: PRK07546 46234008937 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 46234008938 substrate-cofactor binding pocket; other site 46234008939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234008940 catalytic residue [active] 46234008941 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 46234008942 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 46234008943 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 46234008944 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 46234008945 putative active site [active] 46234008946 putative substrate binding site [chemical binding]; other site 46234008947 putative cosubstrate binding site; other site 46234008948 catalytic site [active] 46234008949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 46234008950 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 46234008951 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 46234008952 trimer interface [polypeptide binding]; other site 46234008953 dimer interface [polypeptide binding]; other site 46234008954 putative active site [active] 46234008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234008956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 46234008957 putative substrate translocation pore; other site 46234008958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234008959 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 46234008960 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 46234008961 Ligand binding site; other site 46234008962 Putative Catalytic site; other site 46234008963 DXD motif; other site 46234008964 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 46234008965 NlpC/P60 family; Region: NLPC_P60; pfam00877 46234008966 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 46234008967 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 46234008968 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 46234008969 active site 46234008970 metal binding site [ion binding]; metal-binding site 46234008971 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 46234008972 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 46234008973 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 46234008974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234008975 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 46234008976 putative ADP-binding pocket [chemical binding]; other site 46234008977 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 46234008978 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 46234008979 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234008980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234008981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234008982 active site 46234008983 ATP binding site [chemical binding]; other site 46234008984 substrate binding site [chemical binding]; other site 46234008985 activation loop (A-loop); other site 46234008986 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 46234008987 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 46234008988 TPP-binding site; other site 46234008989 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 46234008990 PYR/PP interface [polypeptide binding]; other site 46234008991 dimer interface [polypeptide binding]; other site 46234008992 TPP binding site [chemical binding]; other site 46234008993 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 46234008994 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 46234008995 DNA-binding interface [nucleotide binding]; DNA binding site 46234008996 ferredoxin-sulfite reductase; Region: sir; TIGR02042 46234008997 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234008998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234008999 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 46234009000 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 46234009001 NADP binding site [chemical binding]; other site 46234009002 active site 46234009003 putative substrate binding site [chemical binding]; other site 46234009004 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 46234009005 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 46234009006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234009007 FeS/SAM binding site; other site 46234009008 TRAM domain; Region: TRAM; pfam01938 46234009009 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 46234009010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234009011 FeS/SAM binding site; other site 46234009012 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 46234009013 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 46234009014 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 46234009015 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 46234009016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234009017 catalytic residue [active] 46234009018 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 46234009019 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 46234009020 trimerization site [polypeptide binding]; other site 46234009021 active site 46234009022 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 46234009023 NifU-like domain; Region: NifU; pfam01106 46234009024 nitrogenase reductase; Reviewed; Region: PRK13236 46234009025 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 46234009026 Nucleotide-binding sites [chemical binding]; other site 46234009027 Walker A motif; other site 46234009028 Switch I region of nucleotide binding site; other site 46234009029 Fe4S4 binding sites [ion binding]; other site 46234009030 Switch II region of nucleotide binding site; other site 46234009031 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234009032 oligomeric interface; other site 46234009033 putative active site [active] 46234009034 homodimer interface [polypeptide binding]; other site 46234009035 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 46234009036 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 46234009037 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 46234009038 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 46234009039 nudix motif; other site 46234009040 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 46234009041 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 46234009042 NACHT domain; Region: NACHT; pfam05729 46234009043 Caspase domain; Region: Peptidase_C14; pfam00656 46234009044 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234009045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234009046 structural tetrad; other site 46234009047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234009048 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 46234009049 Walker A motif; other site 46234009050 ATP binding site [chemical binding]; other site 46234009051 Walker B motif; other site 46234009052 arginine finger; other site 46234009053 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 46234009054 CHAT domain; Region: CHAT; cl17868 46234009055 Double zinc ribbon; Region: DZR; pfam12773 46234009056 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 46234009057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009059 active site 46234009060 ATP binding site [chemical binding]; other site 46234009061 substrate binding site [chemical binding]; other site 46234009062 activation loop (A-loop); other site 46234009063 CHAT domain; Region: CHAT; cl17868 46234009064 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 46234009065 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 46234009066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009068 active site 46234009069 ATP binding site [chemical binding]; other site 46234009070 substrate binding site [chemical binding]; other site 46234009071 activation loop (A-loop); other site 46234009072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009073 binding surface 46234009074 TPR motif; other site 46234009075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009076 binding surface 46234009077 TPR motif; other site 46234009078 TPR repeat; Region: TPR_11; pfam13414 46234009079 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 46234009080 activation loop (A-loop); other site 46234009081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 46234009082 Protein phosphatase 2C; Region: PP2C; pfam00481 46234009083 active site 46234009084 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 46234009085 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234009086 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234009087 phosphopeptide binding site; other site 46234009088 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 46234009089 metal ion-dependent adhesion site (MIDAS); other site 46234009090 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 46234009091 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 46234009092 metal ion-dependent adhesion site (MIDAS); other site 46234009093 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 46234009094 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 46234009095 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 46234009096 metal ion-dependent adhesion site (MIDAS); other site 46234009097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 46234009098 AAA-like domain; Region: AAA_10; pfam12846 46234009099 Walker A motif; other site 46234009100 ATP binding site [chemical binding]; other site 46234009101 Walker B motif; other site 46234009102 AAA ATPase domain; Region: AAA_16; pfam13191 46234009103 Uncharacterized conserved protein [Function unknown]; Region: COG4278 46234009104 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 46234009105 IHF - DNA interface [nucleotide binding]; other site 46234009106 IHF dimer interface [polypeptide binding]; other site 46234009107 Calx-beta domain; Region: Calx-beta; cl02522 46234009108 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 46234009109 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 46234009110 Ycf46; Provisional; Region: ycf46; CHL00195 46234009111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234009112 Walker A motif; other site 46234009113 ATP binding site [chemical binding]; other site 46234009114 Walker B motif; other site 46234009115 arginine finger; other site 46234009116 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 46234009117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 46234009118 non-specific DNA binding site [nucleotide binding]; other site 46234009119 salt bridge; other site 46234009120 sequence-specific DNA binding site [nucleotide binding]; other site 46234009121 D5 N terminal like; Region: D5_N; pfam08706 46234009122 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 46234009123 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 46234009124 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 46234009125 catalytic residues [active] 46234009126 catalytic nucleophile [active] 46234009127 Presynaptic Site I dimer interface [polypeptide binding]; other site 46234009128 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 46234009129 Synaptic Flat tetramer interface [polypeptide binding]; other site 46234009130 Synaptic Site I dimer interface [polypeptide binding]; other site 46234009131 DNA binding site [nucleotide binding] 46234009132 Recombinase; Region: Recombinase; pfam07508 46234009133 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 46234009134 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 46234009135 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 46234009136 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 46234009137 active site 46234009138 catalytic residues [active] 46234009139 DNA binding site [nucleotide binding] 46234009140 Int/Topo IB signature motif; other site 46234009141 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 46234009142 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 46234009143 MoFe protein alpha/beta subunit interactions; other site 46234009144 Alpha subunit P cluster binding residues; other site 46234009145 FeMoco binding residues [chemical binding]; other site 46234009146 MoFe protein alpha subunit/Fe protein contacts; other site 46234009147 MoFe protein dimer/ dimer interactions; other site 46234009148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234009149 AAA domain; Region: AAA_22; pfam13401 46234009150 Walker A motif; other site 46234009151 ATP binding site [chemical binding]; other site 46234009152 Walker B motif; other site 46234009153 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 46234009154 metal ion-dependent adhesion site (MIDAS); other site 46234009155 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 46234009156 active site 46234009157 TPR repeat; Region: TPR_11; pfam13414 46234009158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009159 binding surface 46234009160 TPR motif; other site 46234009161 Protein kinase domain; Region: Pkinase; pfam00069 46234009162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009163 active site 46234009164 substrate binding site [chemical binding]; other site 46234009165 activation loop (A-loop); other site 46234009166 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234009167 oligomeric interface; other site 46234009168 putative active site [active] 46234009169 homodimer interface [polypeptide binding]; other site 46234009170 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009171 putative active site [active] 46234009172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 46234009173 NACHT domain; Region: NACHT; pfam05729 46234009174 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234009175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 46234009176 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009177 putative active site [active] 46234009178 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009179 putative active site [active] 46234009180 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 46234009181 active site 46234009182 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009183 putative active site [active] 46234009184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234009185 AAA domain; Region: AAA_21; pfam13304 46234009186 Walker A/P-loop; other site 46234009187 ATP binding site [chemical binding]; other site 46234009188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 46234009189 Walker B; other site 46234009190 D-loop; other site 46234009191 H-loop/switch region; other site 46234009192 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234009193 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 46234009194 active site 46234009195 catalytic residues [active] 46234009196 DNA binding site [nucleotide binding] 46234009197 Int/Topo IB signature motif; other site 46234009198 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 46234009199 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 46234009200 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 46234009201 MoFe protein beta/alpha subunit interactions; other site 46234009202 Beta subunit P cluster binding residues; other site 46234009203 MoFe protein beta subunit/Fe protein contacts; other site 46234009204 MoFe protein dimer/ dimer interactions; other site 46234009205 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 46234009206 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 46234009207 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 46234009208 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 46234009209 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 46234009210 Protein of unknown function, DUF269; Region: DUF269; pfam03270 46234009211 Rop-like; Region: Rop-like; pfam05082 46234009212 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 46234009213 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 46234009214 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 46234009215 ATP binding site [chemical binding]; other site 46234009216 substrate interface [chemical binding]; other site 46234009217 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 46234009218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234009219 catalytic loop [active] 46234009220 iron binding site [ion binding]; other site 46234009221 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 46234009222 Uncharacterized conserved protein [Function unknown]; Region: COG2442 46234009223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 46234009224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 46234009225 binding surface 46234009226 TPR motif; other site 46234009227 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 46234009228 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 46234009229 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 46234009230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 46234009231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 46234009232 catalytic residue [active] 46234009233 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009234 putative active site [active] 46234009235 Ion transport protein; Region: Ion_trans; pfam00520 46234009236 Ion channel; Region: Ion_trans_2; pfam07885 46234009237 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 46234009238 RDD family; Region: RDD; pfam06271 46234009239 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 46234009240 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009241 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009242 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009243 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009244 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009245 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009246 active site 46234009247 ATP binding site [chemical binding]; other site 46234009248 substrate binding site [chemical binding]; other site 46234009249 activation loop (A-loop); other site 46234009250 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 46234009251 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 46234009252 catalytic motif [active] 46234009253 Catalytic residue [active] 46234009254 Haemolytic domain; Region: Haemolytic; pfam01809 46234009255 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 46234009256 HlyD family secretion protein; Region: HlyD; pfam00529 46234009257 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234009258 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 46234009259 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 46234009260 putative active site [active] 46234009261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234009262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234009263 Walker A/P-loop; other site 46234009264 ATP binding site [chemical binding]; other site 46234009265 Q-loop/lid; other site 46234009266 ABC transporter signature motif; other site 46234009267 Walker B; other site 46234009268 D-loop; other site 46234009269 H-loop/switch region; other site 46234009270 hydrolase, alpha/beta fold family protein; Region: PLN02824 46234009271 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 46234009272 putative nucleotide binding site [chemical binding]; other site 46234009273 uridine monophosphate binding site [chemical binding]; other site 46234009274 homohexameric interface [polypeptide binding]; other site 46234009275 ribosome recycling factor; Reviewed; Region: frr; PRK00083 46234009276 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 46234009277 hinge region; other site 46234009278 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 46234009279 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234009280 oligomeric interface; other site 46234009281 putative active site [active] 46234009282 homodimer interface [polypeptide binding]; other site 46234009283 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 46234009284 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234009285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234009286 S-adenosylmethionine binding site [chemical binding]; other site 46234009287 Methyltransferase domain; Region: Methyltransf_26; pfam13659 46234009288 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 46234009289 Ycf46; Provisional; Region: ycf46; CHL00195 46234009290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234009291 Walker A motif; other site 46234009292 ATP binding site [chemical binding]; other site 46234009293 Walker B motif; other site 46234009294 arginine finger; other site 46234009295 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 46234009296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234009297 AAA ATPase domain; Region: AAA_15; pfam13175 46234009298 Walker A/P-loop; other site 46234009299 ATP binding site [chemical binding]; other site 46234009300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234009301 Q-loop/lid; other site 46234009302 ABC transporter signature motif; other site 46234009303 Walker B; other site 46234009304 D-loop; other site 46234009305 H-loop/switch region; other site 46234009306 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 46234009307 PhoH-like protein; Region: PhoH; pfam02562 46234009308 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 46234009309 KH domain; Region: KH_4; pfam13083 46234009310 ribosomal protein S16; Region: rps16; CHL00005 46234009311 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 46234009312 putative active site [active] 46234009313 putative catalytic triad [active] 46234009314 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 46234009315 XisI protein; Region: XisI; pfam08869 46234009316 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009317 putative active site [active] 46234009318 Transposase IS200 like; Region: Y1_Tnp; pfam01797 46234009319 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 46234009320 putative active site [active] 46234009321 putative catalytic triad [active] 46234009322 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 46234009323 cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220 46234009324 signal recognition particle protein; Provisional; Region: PRK10867 46234009325 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 46234009326 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 46234009327 GTP binding site [chemical binding]; other site 46234009328 Signal peptide binding domain; Region: SRP_SPB; pfam02978 46234009329 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 46234009330 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 46234009331 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 46234009332 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 46234009333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234009334 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 46234009335 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 46234009336 dimerization interface [polypeptide binding]; other site 46234009337 domain crossover interface; other site 46234009338 redox-dependent activation switch; other site 46234009339 CAAX protease self-immunity; Region: Abi; cl00558 46234009340 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 46234009341 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 46234009342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234009343 catalytic loop [active] 46234009344 iron binding site [ion binding]; other site 46234009345 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 46234009346 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 46234009347 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 46234009348 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 46234009349 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 46234009350 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 46234009351 Predicted integral membrane protein [Function unknown]; Region: COG0762 46234009352 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 46234009353 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 46234009354 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 46234009355 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 46234009356 Protein of unknown function (DUF98); Region: DUF98; pfam01947 46234009357 TPR repeat; Region: TPR_11; pfam13414 46234009358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009359 TPR motif; other site 46234009360 binding surface 46234009361 TPR repeat; Region: TPR_11; pfam13414 46234009362 TPR repeat; Region: TPR_11; pfam13414 46234009363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009364 binding surface 46234009365 TPR motif; other site 46234009366 TPR repeat; Region: TPR_11; pfam13414 46234009367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009368 binding surface 46234009369 TPR motif; other site 46234009370 TPR repeat; Region: TPR_11; pfam13414 46234009371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009372 binding surface 46234009373 TPR motif; other site 46234009374 cytochrome c biogenesis protein; Region: ccsA; CHL00045 46234009375 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 46234009376 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 46234009377 Surface antigen; Region: Surface_Ag_2; pfam01617 46234009378 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 46234009379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009380 TPR repeat; Region: TPR_11; pfam13414 46234009381 binding surface 46234009382 TPR motif; other site 46234009383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009384 binding surface 46234009385 TPR motif; other site 46234009386 TPR repeat; Region: TPR_11; pfam13414 46234009387 Archaeal ATPase; Region: Arch_ATPase; pfam01637 46234009388 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 46234009389 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234009390 putative ligand binding site [chemical binding]; other site 46234009391 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009392 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009393 active site 46234009394 ATP binding site [chemical binding]; other site 46234009395 substrate binding site [chemical binding]; other site 46234009396 activation loop (A-loop); other site 46234009397 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 46234009398 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 46234009399 Ligand Binding Site [chemical binding]; other site 46234009400 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 46234009401 Response regulator receiver domain; Region: Response_reg; pfam00072 46234009402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234009403 active site 46234009404 phosphorylation site [posttranslational modification] 46234009405 intermolecular recognition site; other site 46234009406 dimerization interface [polypeptide binding]; other site 46234009407 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 46234009408 TPR repeat; Region: TPR_11; pfam13414 46234009409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009410 binding surface 46234009411 TPR motif; other site 46234009412 HAMP domain; Region: HAMP; pfam00672 46234009413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 46234009414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 46234009415 dimer interface [polypeptide binding]; other site 46234009416 putative CheW interface [polypeptide binding]; other site 46234009417 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 46234009418 putative binding surface; other site 46234009419 active site 46234009420 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 46234009421 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 46234009422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234009423 ATP binding site [chemical binding]; other site 46234009424 Mg2+ binding site [ion binding]; other site 46234009425 G-X-G motif; other site 46234009426 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 46234009427 Response regulator receiver domain; Region: Response_reg; pfam00072 46234009428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234009429 active site 46234009430 phosphorylation site [posttranslational modification] 46234009431 intermolecular recognition site; other site 46234009432 dimerization interface [polypeptide binding]; other site 46234009433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 46234009434 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 46234009435 TM-ABC transporter signature motif; other site 46234009436 PsaX family; Region: PsaX; pfam08078 46234009437 lipoyl synthase; Provisional; Region: PRK12928 46234009438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234009439 FeS/SAM binding site; other site 46234009440 Response regulator receiver domain; Region: Response_reg; pfam00072 46234009441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234009442 active site 46234009443 phosphorylation site [posttranslational modification] 46234009444 intermolecular recognition site; other site 46234009445 dimerization interface [polypeptide binding]; other site 46234009446 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009447 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009448 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009449 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 46234009450 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234009451 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009452 putative active site [active] 46234009453 MarR family; Region: MarR_2; cl17246 46234009454 YcfA-like protein; Region: YcfA; pfam07927 46234009455 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234009456 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 46234009457 PIN domain; Region: PIN_3; cl17397 46234009458 aspartoacylase; Provisional; Region: PRK02259 46234009459 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 46234009460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 46234009461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 46234009462 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 46234009463 dimerization interface [polypeptide binding]; other site 46234009464 substrate binding pocket [chemical binding]; other site 46234009465 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009466 putative active site [active] 46234009467 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 46234009468 putative active site [active] 46234009469 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 46234009470 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 46234009471 active site 46234009472 interdomain interaction site; other site 46234009473 putative metal-binding site [ion binding]; other site 46234009474 nucleotide binding site [chemical binding]; other site 46234009475 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 46234009476 domain I; other site 46234009477 phosphate binding site [ion binding]; other site 46234009478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 46234009479 domain II; other site 46234009480 domain III; other site 46234009481 nucleotide binding site [chemical binding]; other site 46234009482 DNA binding groove [nucleotide binding] 46234009483 catalytic site [active] 46234009484 domain IV; other site 46234009485 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 46234009486 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 46234009487 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 46234009488 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 46234009489 Dehydroquinase class II; Region: DHquinase_II; pfam01220 46234009490 trimer interface [polypeptide binding]; other site 46234009491 active site 46234009492 dimer interface [polypeptide binding]; other site 46234009493 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 46234009494 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 46234009495 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 46234009496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 46234009497 Zn2+ binding site [ion binding]; other site 46234009498 Mg2+ binding site [ion binding]; other site 46234009499 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 46234009500 metal ion-dependent adhesion site (MIDAS); other site 46234009501 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 46234009502 metal ion-dependent adhesion site (MIDAS); other site 46234009503 Transposase IS200 like; Region: Y1_Tnp; pfam01797 46234009504 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 46234009505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 46234009506 Uncharacterized conserved protein [Function unknown]; Region: COG1259 46234009507 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 46234009508 Lumazine binding domain; Region: Lum_binding; pfam00677 46234009509 Lumazine binding domain; Region: Lum_binding; pfam00677 46234009510 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 46234009511 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234009512 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 46234009513 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 46234009514 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 46234009515 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 46234009516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009517 putative active site [active] 46234009518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234009519 Probable transposase; Region: OrfB_IS605; pfam01385 46234009520 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234009521 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 46234009522 CP12 domain; Region: CP12; pfam02672 46234009523 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 46234009524 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 46234009525 GMP synthase; Reviewed; Region: guaA; PRK00074 46234009526 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 46234009527 AMP/PPi binding site [chemical binding]; other site 46234009528 candidate oxyanion hole; other site 46234009529 catalytic triad [active] 46234009530 potential glutamine specificity residues [chemical binding]; other site 46234009531 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 46234009532 ATP Binding subdomain [chemical binding]; other site 46234009533 Ligand Binding sites [chemical binding]; other site 46234009534 Dimerization subdomain; other site 46234009535 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 46234009536 GSH binding site [chemical binding]; other site 46234009537 catalytic residues [active] 46234009538 glutathione synthetase; Provisional; Region: PRK05246 46234009539 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 46234009540 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 46234009541 cell division protein FtsZ; Validated; Region: PRK09330 46234009542 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 46234009543 nucleotide binding site [chemical binding]; other site 46234009544 SulA interaction site; other site 46234009545 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 46234009546 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 46234009547 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 46234009548 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 46234009549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234009550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234009551 DNA binding residues [nucleotide binding] 46234009552 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 46234009553 PsbJ; Region: PsbJ; cl09469 46234009554 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 46234009555 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 46234009556 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 46234009557 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 46234009558 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 46234009559 Ycf48-like protein; Provisional; Region: PRK13684 46234009560 Rubredoxin [Energy production and conversion]; Region: COG1773 46234009561 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 46234009562 iron binding site [ion binding]; other site 46234009563 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009564 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009565 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009566 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 46234009567 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 46234009568 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 46234009569 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 46234009570 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 46234009571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234009572 Probable transposase; Region: OrfB_IS605; pfam01385 46234009573 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 46234009574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009576 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234009577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009578 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009579 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234009580 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 46234009581 homotrimer interaction site [polypeptide binding]; other site 46234009582 putative active site [active] 46234009583 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 46234009584 nudix motif; other site 46234009585 4-alpha-glucanotransferase; Provisional; Region: PRK14508 46234009586 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 46234009587 Helix-turn-helix domain; Region: HTH_25; pfam13413 46234009588 non-specific DNA binding site [nucleotide binding]; other site 46234009589 salt bridge; other site 46234009590 sequence-specific DNA binding site [nucleotide binding]; other site 46234009591 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 46234009592 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 46234009593 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234009594 RNA binding surface [nucleotide binding]; other site 46234009595 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 46234009596 active site 46234009597 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 46234009598 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 46234009599 phosphatidate cytidylyltransferase; Region: PLN02953 46234009600 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 46234009601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234009602 S-adenosylmethionine binding site [chemical binding]; other site 46234009603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009605 active site 46234009606 ATP binding site [chemical binding]; other site 46234009607 substrate binding site [chemical binding]; other site 46234009608 activation loop (A-loop); other site 46234009609 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 46234009610 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 46234009611 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 46234009612 glutaminase; Provisional; Region: PRK00971 46234009613 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 46234009614 active site 46234009615 dimer interface [polypeptide binding]; other site 46234009616 metal binding site [ion binding]; metal-binding site 46234009617 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234009618 oligomeric interface; other site 46234009619 putative active site [active] 46234009620 homodimer interface [polypeptide binding]; other site 46234009621 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 46234009622 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 46234009623 putative active site [active] 46234009624 TIR domain; Region: TIR_2; pfam13676 46234009625 GUN4-like; Region: GUN4; pfam05419 46234009626 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 46234009627 biotin synthase; Region: bioB; TIGR00433 46234009628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234009629 FeS/SAM binding site; other site 46234009630 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 46234009631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 46234009632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 46234009633 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 46234009634 Uncharacterized conserved protein [Function unknown]; Region: COG0397 46234009635 hypothetical protein; Validated; Region: PRK00029 46234009636 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234009637 YcfA-like protein; Region: YcfA; cl00752 46234009638 Predicted kinase [General function prediction only]; Region: COG4240 46234009639 active site 46234009640 Protein of unknown function (DUF565); Region: DUF565; pfam04483 46234009641 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 46234009642 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 46234009643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 46234009644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234009645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234009646 dimer interface [polypeptide binding]; other site 46234009647 phosphorylation site [posttranslational modification] 46234009648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234009649 ATP binding site [chemical binding]; other site 46234009650 Mg2+ binding site [ion binding]; other site 46234009651 G-X-G motif; other site 46234009652 Response regulator receiver domain; Region: Response_reg; pfam00072 46234009653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234009654 active site 46234009655 phosphorylation site [posttranslational modification] 46234009656 intermolecular recognition site; other site 46234009657 dimerization interface [polypeptide binding]; other site 46234009658 KaiA domain; Region: KaiA; pfam07688 46234009659 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 46234009660 tetramer interface [polypeptide binding]; other site 46234009661 dimer interface [polypeptide binding]; other site 46234009662 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 46234009663 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 46234009664 Walker A motif; other site 46234009665 ATP binding site [chemical binding]; other site 46234009666 Walker B motif; other site 46234009667 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 46234009668 ATP binding site [chemical binding]; other site 46234009669 Walker B motif; other site 46234009670 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 46234009671 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 46234009672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 46234009673 RNA binding surface [nucleotide binding]; other site 46234009674 DNA polymerase III PolC; Validated; Region: polC; PRK00448 46234009675 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 46234009676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234009677 FeS/SAM binding site; other site 46234009678 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 46234009679 active site 46234009680 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 46234009681 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 46234009682 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 46234009683 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 46234009684 Ankyrin repeat; Region: Ank; pfam00023 46234009685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 46234009686 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 46234009687 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 46234009688 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 46234009689 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 46234009690 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 46234009691 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 46234009692 catalytic residue [active] 46234009693 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 46234009694 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 46234009695 Peptidase family M48; Region: Peptidase_M48; pfam01435 46234009696 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 46234009697 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 46234009698 active site 46234009699 metal binding site [ion binding]; metal-binding site 46234009700 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 46234009701 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 46234009702 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 46234009703 putative active site [active] 46234009704 putative NTP binding site [chemical binding]; other site 46234009705 putative nucleic acid binding site [nucleotide binding]; other site 46234009706 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 46234009707 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234009708 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234009709 active site 46234009710 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 46234009711 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 46234009712 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 46234009713 active site 46234009714 NTP binding site [chemical binding]; other site 46234009715 metal binding triad [ion binding]; metal-binding site 46234009716 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 46234009717 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 46234009718 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 46234009719 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 46234009720 Glycoprotease family; Region: Peptidase_M22; pfam00814 46234009721 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 46234009722 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 46234009723 dimer interface [polypeptide binding]; other site 46234009724 PYR/PP interface [polypeptide binding]; other site 46234009725 TPP binding site [chemical binding]; other site 46234009726 substrate binding site [chemical binding]; other site 46234009727 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 46234009728 Domain of unknown function; Region: EKR; pfam10371 46234009729 4Fe-4S binding domain; Region: Fer4_6; pfam12837 46234009730 4Fe-4S binding domain; Region: Fer4; pfam00037 46234009731 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 46234009732 TPP-binding site [chemical binding]; other site 46234009733 dimer interface [polypeptide binding]; other site 46234009734 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 46234009735 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 46234009736 iron-sulfur cluster [ion binding]; other site 46234009737 [2Fe-2S] cluster binding site [ion binding]; other site 46234009738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 46234009739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 46234009740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 46234009741 dimerization interface [polypeptide binding]; other site 46234009742 hypothetical protein; Provisional; Region: PRK07394 46234009743 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 46234009744 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 46234009745 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 46234009746 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 46234009747 [4Fe-4S] binding site [ion binding]; other site 46234009748 molybdopterin cofactor binding site; other site 46234009749 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 46234009750 molybdopterin cofactor binding site; other site 46234009751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234009753 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 46234009754 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234009755 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234009756 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 46234009757 putative active site [active] 46234009758 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 46234009759 tetramerization interface [polypeptide binding]; other site 46234009760 active site 46234009761 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 46234009762 dimer interface [polypeptide binding]; other site 46234009763 substrate binding site [chemical binding]; other site 46234009764 metal binding sites [ion binding]; metal-binding site 46234009765 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 46234009766 Calx-beta domain; Region: Calx-beta; cl02522 46234009767 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234009768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 46234009769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234009770 substrate binding pocket [chemical binding]; other site 46234009771 membrane-bound complex binding site; other site 46234009772 hinge residues; other site 46234009773 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 46234009774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234009775 substrate binding pocket [chemical binding]; other site 46234009776 membrane-bound complex binding site; other site 46234009777 hinge residues; other site 46234009778 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 46234009779 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 46234009780 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 46234009781 Family description; Region: VCBS; pfam13517 46234009782 Family description; Region: VCBS; pfam13517 46234009783 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 46234009784 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 46234009785 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 46234009786 sugar binding site [chemical binding]; other site 46234009787 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 46234009788 calcium mediated ligand binding site; other site 46234009789 intermolecular salt bridges; other site 46234009790 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 46234009791 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 46234009792 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 46234009793 Calx-beta domain; Region: Calx-beta; cl02522 46234009794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 46234009795 non-specific DNA binding site [nucleotide binding]; other site 46234009796 salt bridge; other site 46234009797 sequence-specific DNA binding site [nucleotide binding]; other site 46234009798 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 46234009799 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 46234009800 dimerization interface [polypeptide binding]; other site 46234009801 active site 46234009802 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 46234009803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234009804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234009805 homodimer interface [polypeptide binding]; other site 46234009806 catalytic residue [active] 46234009807 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234009808 catalytic residues [active] 46234009809 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 46234009810 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 46234009811 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 46234009812 Protein of unknown function (DUF721); Region: DUF721; cl02324 46234009813 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 46234009814 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 46234009815 substrate binding site [chemical binding]; other site 46234009816 oxyanion hole (OAH) forming residues; other site 46234009817 trimer interface [polypeptide binding]; other site 46234009818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234009819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234009820 active site 46234009821 ATP binding site [chemical binding]; other site 46234009822 substrate binding site [chemical binding]; other site 46234009823 activation loop (A-loop); other site 46234009824 XisI protein; Region: XisI; pfam08869 46234009825 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 46234009826 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234009827 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234009828 TPR repeat; Region: TPR_11; pfam13414 46234009829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009830 binding surface 46234009831 TPR motif; other site 46234009832 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234009833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009834 binding surface 46234009835 TPR motif; other site 46234009836 Tetratricopeptide repeat; Region: TPR_1; pfam00515 46234009837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009838 binding surface 46234009839 TPR motif; other site 46234009840 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234009841 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234009842 Circadian oscillating protein COP23; Region: COP23; pfam14218 46234009843 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234009844 putative active site [active] 46234009845 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 46234009846 transketolase; Region: PLN02790 46234009847 TPP-binding site [chemical binding]; other site 46234009848 dimer interface [polypeptide binding]; other site 46234009849 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 46234009850 PYR/PP interface [polypeptide binding]; other site 46234009851 dimer interface [polypeptide binding]; other site 46234009852 TPP binding site [chemical binding]; other site 46234009853 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 46234009854 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 46234009855 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 46234009856 dimer interface [polypeptide binding]; other site 46234009857 active site 46234009858 acyl carrier protein; Provisional; Region: acpP; PRK00982 46234009859 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 46234009860 Cysteine-rich domain; Region: CCG; pfam02754 46234009861 Cysteine-rich domain; Region: CCG; pfam02754 46234009862 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 46234009863 active site 46234009864 catalytic residues [active] 46234009865 metal binding site [ion binding]; metal-binding site 46234009866 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234009867 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 46234009868 protein binding site [polypeptide binding]; other site 46234009869 Restriction endonuclease; Region: Mrr_cat; pfam04471 46234009870 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 46234009871 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234009872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 46234009873 minor groove reading motif; other site 46234009874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 46234009875 active site 46234009876 Int/Topo IB signature motif; other site 46234009877 DNA binding site [nucleotide binding] 46234009878 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 46234009879 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234009880 active site 46234009881 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 46234009882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009883 binding surface 46234009884 TPR motif; other site 46234009885 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 46234009886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009887 binding surface 46234009888 TPR motif; other site 46234009889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009890 binding surface 46234009891 TPR motif; other site 46234009892 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234009893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234009894 CHAT domain; Region: CHAT; pfam12770 46234009895 Caspase domain; Region: Peptidase_C14; pfam00656 46234009896 PGAP1-like protein; Region: PGAP1; pfam07819 46234009897 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 46234009898 nucleotide binding site [chemical binding]; other site 46234009899 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 46234009900 ParB-like nuclease domain; Region: ParB; smart00470 46234009901 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 46234009902 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234009903 P-loop; other site 46234009904 Magnesium ion binding site [ion binding]; other site 46234009905 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234009906 Magnesium ion binding site [ion binding]; other site 46234009907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 46234009908 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 46234009909 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 46234009910 active site 46234009911 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 46234009912 hypothetical protein; Provisional; Region: PRK13560 46234009913 Staphylococcal nuclease homologues; Region: SNc; smart00318 46234009914 Catalytic site; other site 46234009915 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 46234009916 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 46234009917 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 46234009918 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 46234009919 active site 46234009920 catalytic site [active] 46234009921 substrate binding site [chemical binding]; other site 46234009922 V-type ATP synthase subunit I; Validated; Region: PRK05771 46234009923 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 46234009924 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 46234009925 non-specific DNA binding site [nucleotide binding]; other site 46234009926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 46234009927 salt bridge; other site 46234009928 sequence-specific DNA binding site [nucleotide binding]; other site 46234009929 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 46234009930 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 46234009931 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234009932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234009933 S-adenosylmethionine binding site [chemical binding]; other site 46234009934 SdpI/YhfL protein family; Region: SdpI; pfam13630 46234009935 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 46234009936 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 46234009937 Dynamin family; Region: Dynamin_N; pfam00350 46234009938 G1 box; other site 46234009939 GTP/Mg2+ binding site [chemical binding]; other site 46234009940 G2 box; other site 46234009941 Switch I region; other site 46234009942 G3 box; other site 46234009943 Switch II region; other site 46234009944 G4 box; other site 46234009945 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 46234009946 Dynamin family; Region: Dynamin_N; pfam00350 46234009947 G1 box; other site 46234009948 GTP/Mg2+ binding site [chemical binding]; other site 46234009949 G2 box; other site 46234009950 Switch I region; other site 46234009951 G3 box; other site 46234009952 Switch II region; other site 46234009953 G4 box; other site 46234009954 G5 box; other site 46234009955 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 46234009956 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 46234009957 nucleotide binding site [chemical binding]; other site 46234009958 putative NEF/HSP70 interaction site [polypeptide binding]; other site 46234009959 SBD interface [polypeptide binding]; other site 46234009960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 46234009961 non-specific DNA binding site [nucleotide binding]; other site 46234009962 salt bridge; other site 46234009963 sequence-specific DNA binding site [nucleotide binding]; other site 46234009964 CHAT domain; Region: CHAT; cl17868 46234009965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234009966 Walker A motif; other site 46234009967 ATP binding site [chemical binding]; other site 46234009968 Walker B motif; other site 46234009969 arginine finger; other site 46234009970 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234009971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234009972 binding surface 46234009973 TPR motif; other site 46234009974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234009975 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 46234009976 WYL domain; Region: WYL; pfam13280 46234009977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 46234009978 active site 46234009979 DNA binding site [nucleotide binding] 46234009980 Int/Topo IB signature motif; other site 46234009981 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 46234009982 Helix-turn-helix domain; Region: HTH_17; pfam12728 46234009983 Helix-turn-helix domain; Region: HTH_17; cl17695 46234009984 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 46234009985 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 46234009986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 46234009987 AAA domain; Region: AAA_22; pfam13401 46234009988 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 46234009989 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 46234009990 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 46234009991 putative active site [active] 46234009992 putative NTP binding site [chemical binding]; other site 46234009993 putative nucleic acid binding site [nucleotide binding]; other site 46234009994 hypothetical protein; Region: PHA00652 46234009995 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234009996 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234009997 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234009998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234009999 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010000 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010001 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 46234010002 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 46234010003 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 46234010004 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 46234010005 putative active site [active] 46234010006 putative NTP binding site [chemical binding]; other site 46234010007 putative nucleic acid binding site [nucleotide binding]; other site 46234010008 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 46234010009 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234010010 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234010011 active site 46234010012 Peptidase family S49; Region: Peptidase_S49; pfam01343 46234010013 Phage associated DNA primase [General function prediction only]; Region: COG3378 46234010014 D5 N terminal like; Region: D5_N; pfam08706 46234010015 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 46234010016 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 46234010017 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 46234010018 putative active site [active] 46234010019 putative NTP binding site [chemical binding]; other site 46234010020 putative nucleic acid binding site [nucleotide binding]; other site 46234010021 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 46234010022 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234010023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234010024 active site 46234010025 hypothetical protein; Validated; Region: PRK07078 46234010026 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 46234010027 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234010028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234010029 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010030 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010031 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 46234010032 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 46234010033 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 46234010034 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 46234010035 four helix bundle protein; Region: TIGR02436 46234010036 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 46234010037 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 46234010038 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 46234010039 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 46234010040 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 46234010041 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 46234010042 Protein of unknown function DUF86; Region: DUF86; pfam01934 46234010043 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 46234010044 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 46234010045 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 46234010046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 46234010047 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 46234010048 ribosomal protein S20; Region: rps20; CHL00102 46234010049 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 46234010050 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 46234010051 active site 46234010052 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 46234010053 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 46234010054 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 46234010055 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 46234010056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 46234010057 RPB10 interaction site [polypeptide binding]; other site 46234010058 RPB1 interaction site [polypeptide binding]; other site 46234010059 RPB11 interaction site [polypeptide binding]; other site 46234010060 RPB3 interaction site [polypeptide binding]; other site 46234010061 RPB12 interaction site [polypeptide binding]; other site 46234010062 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 46234010063 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 46234010064 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 46234010065 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 46234010066 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 46234010067 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 46234010068 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 46234010069 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 46234010070 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 46234010071 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 46234010072 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 46234010073 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 46234010074 DNA binding site [nucleotide binding] 46234010075 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 46234010076 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 46234010077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 46234010078 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 46234010079 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 46234010080 Pirin-related protein [General function prediction only]; Region: COG1741 46234010081 Pirin; Region: Pirin; pfam02678 46234010082 urease subunit alpha; Reviewed; Region: ureC; PRK13207 46234010083 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 46234010084 subunit interactions [polypeptide binding]; other site 46234010085 active site 46234010086 flap region; other site 46234010087 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 46234010088 gamma-beta subunit interface [polypeptide binding]; other site 46234010089 alpha-beta subunit interface [polypeptide binding]; other site 46234010090 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 46234010091 alpha-gamma subunit interface [polypeptide binding]; other site 46234010092 beta-gamma subunit interface [polypeptide binding]; other site 46234010093 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 46234010094 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 46234010095 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234010096 P-loop; other site 46234010097 Magnesium ion binding site [ion binding]; other site 46234010098 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234010099 Magnesium ion binding site [ion binding]; other site 46234010100 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 46234010101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234010102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010103 active site 46234010104 phosphorylation site [posttranslational modification] 46234010105 intermolecular recognition site; other site 46234010106 dimerization interface [polypeptide binding]; other site 46234010107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234010108 DNA binding residues [nucleotide binding] 46234010109 dimerization interface [polypeptide binding]; other site 46234010110 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 46234010111 oligomerisation interface [polypeptide binding]; other site 46234010112 mobile loop; other site 46234010113 roof hairpin; other site 46234010114 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 46234010115 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 46234010116 ring oligomerisation interface [polypeptide binding]; other site 46234010117 ATP/Mg binding site [chemical binding]; other site 46234010118 stacking interactions; other site 46234010119 hinge regions; other site 46234010120 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 46234010121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 46234010122 P-loop; other site 46234010123 Magnesium ion binding site [ion binding]; other site 46234010124 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234010125 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 46234010126 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 46234010127 putative dimer interface [polypeptide binding]; other site 46234010128 putative anticodon binding site; other site 46234010129 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 46234010130 homodimer interface [polypeptide binding]; other site 46234010131 motif 1; other site 46234010132 motif 2; other site 46234010133 active site 46234010134 motif 3; other site 46234010135 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 46234010136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 46234010137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 46234010138 ATP binding site [chemical binding]; other site 46234010139 Mg2+ binding site [ion binding]; other site 46234010140 G-X-G motif; other site 46234010141 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 46234010142 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 46234010143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234010144 S-adenosylmethionine binding site [chemical binding]; other site 46234010145 Phycobilisome protein; Region: Phycobilisome; cl08227 46234010146 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 46234010147 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 46234010148 glutamine binding [chemical binding]; other site 46234010149 catalytic triad [active] 46234010150 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 46234010151 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 46234010152 chorismate binding enzyme; Region: Chorismate_bind; cl10555 46234010153 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 46234010154 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 46234010155 generic binding surface II; other site 46234010156 ssDNA binding site; other site 46234010157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234010158 ATP binding site [chemical binding]; other site 46234010159 putative Mg++ binding site [ion binding]; other site 46234010160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234010161 nucleotide binding region [chemical binding]; other site 46234010162 ATP-binding site [chemical binding]; other site 46234010163 elongation factor Ts; Provisional; Region: tsf; PRK09377 46234010164 UBA/TS-N domain; Region: UBA; pfam00627 46234010165 Elongation factor TS; Region: EF_TS; pfam00889 46234010166 Elongation factor TS; Region: EF_TS; pfam00889 46234010167 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 46234010168 rRNA interaction site [nucleotide binding]; other site 46234010169 S8 interaction site; other site 46234010170 putative laminin-1 binding site; other site 46234010171 Response regulator receiver domain; Region: Response_reg; pfam00072 46234010172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010173 active site 46234010174 phosphorylation site [posttranslational modification] 46234010175 intermolecular recognition site; other site 46234010176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234010177 dimerization interface [polypeptide binding]; other site 46234010178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234010179 phosphorylation site [posttranslational modification] 46234010180 dimer interface [polypeptide binding]; other site 46234010181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234010182 ATP binding site [chemical binding]; other site 46234010183 G-X-G motif; other site 46234010184 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 46234010185 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 46234010186 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 46234010187 Transposase IS200 like; Region: Y1_Tnp; cl00848 46234010188 Transposase IS200 like; Region: Y1_Tnp; cl00848 46234010189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234010190 TAP-like protein; Region: Abhydrolase_4; pfam08386 46234010191 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 46234010192 DevC protein; Region: devC; TIGR01185 46234010193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234010194 FtsX-like permease family; Region: FtsX; pfam02687 46234010195 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 46234010196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 46234010197 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234010198 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 46234010199 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 46234010200 inhibitor-cofactor binding pocket; inhibition site 46234010201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010202 catalytic residue [active] 46234010203 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 46234010204 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 46234010205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 46234010206 metal binding site [ion binding]; metal-binding site 46234010207 Predicted helicase [General function prediction only]; Region: COG4889 46234010208 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 46234010209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234010210 ATP binding site [chemical binding]; other site 46234010211 putative Mg++ binding site [ion binding]; other site 46234010212 amidophosphoribosyltransferase; Provisional; Region: PRK07349 46234010213 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 46234010214 active site 46234010215 tetramer interface [polypeptide binding]; other site 46234010216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234010217 active site 46234010218 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 46234010219 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 46234010220 dimerization interface [polypeptide binding]; other site 46234010221 ATP binding site [chemical binding]; other site 46234010222 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 46234010223 dimerization interface [polypeptide binding]; other site 46234010224 ATP binding site [chemical binding]; other site 46234010225 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234010226 Probable transposase; Region: OrfB_IS605; pfam01385 46234010227 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234010228 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 46234010229 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 46234010230 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 46234010231 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 46234010232 NAD binding site [chemical binding]; other site 46234010233 homodimer interface [polypeptide binding]; other site 46234010234 active site 46234010235 substrate binding site [chemical binding]; other site 46234010236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234010237 active site 46234010238 XisI protein; Region: XisI; pfam08869 46234010239 XisH protein; Region: XisH; pfam08814 46234010240 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 46234010241 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 46234010242 substrate binding site [chemical binding]; other site 46234010243 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 46234010244 substrate binding site [chemical binding]; other site 46234010245 ligand binding site [chemical binding]; other site 46234010246 Uncharacterized conserved protein [Function unknown]; Region: COG1479 46234010247 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234010248 XisH protein; Region: XisH; pfam08814 46234010249 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234010250 XisH protein; Region: XisH; pfam08814 46234010251 XisI protein; Region: XisI; pfam08869 46234010252 Restriction endonuclease; Region: Mrr_cat; pfam04471 46234010253 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 46234010254 putative active site [active] 46234010255 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 46234010256 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 46234010257 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 46234010258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 46234010259 active site 46234010260 Predicted permeases [General function prediction only]; Region: COG0679 46234010261 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 46234010262 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 46234010263 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 46234010264 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 46234010265 putative active site [active] 46234010266 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 46234010267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234010268 FeS/SAM binding site; other site 46234010269 HemN C-terminal domain; Region: HemN_C; pfam06969 46234010270 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234010271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010272 Tetratricopeptide repeat; Region: TPR_10; pfam13374 46234010273 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010275 binding surface 46234010276 TPR motif; other site 46234010277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010279 Tetratricopeptide repeat; Region: TPR_10; pfam13374 46234010280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010282 binding surface 46234010283 TPR motif; other site 46234010284 CHAT domain; Region: CHAT; cl17868 46234010285 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234010286 oligomeric interface; other site 46234010287 putative active site [active] 46234010288 homodimer interface [polypeptide binding]; other site 46234010289 aspartate aminotransferase; Provisional; Region: PRK05942 46234010290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234010291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010292 homodimer interface [polypeptide binding]; other site 46234010293 catalytic residue [active] 46234010294 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 46234010295 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 46234010296 putative active site [active] 46234010297 metal binding site [ion binding]; metal-binding site 46234010298 Protein of function (DUF2518); Region: DUF2518; pfam10726 46234010299 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 46234010300 protein I interface; other site 46234010301 D2 interface; other site 46234010302 protein T interface; other site 46234010303 chlorophyll binding site; other site 46234010304 beta carotene binding site; other site 46234010305 pheophytin binding site; other site 46234010306 manganese-stabilizing polypeptide interface; other site 46234010307 CP43 interface; other site 46234010308 protein L interface; other site 46234010309 oxygen evolving complex binding site; other site 46234010310 bromide binding site; other site 46234010311 quinone binding site; other site 46234010312 Fe binding site [ion binding]; other site 46234010313 core light harvesting interface; other site 46234010314 cytochrome b559 alpha subunit interface; other site 46234010315 cytochrome c-550 interface; other site 46234010316 protein J interface; other site 46234010317 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 46234010318 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 46234010319 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 46234010320 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234010321 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 46234010322 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 46234010323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 46234010324 protein binding site [polypeptide binding]; other site 46234010325 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 46234010326 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 46234010327 substrate binding site; other site 46234010328 dimer interface; other site 46234010329 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 46234010330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 46234010331 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 46234010332 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 46234010333 metal binding site 2 [ion binding]; metal-binding site 46234010334 putative DNA binding helix; other site 46234010335 metal binding site 1 [ion binding]; metal-binding site 46234010336 dimer interface [polypeptide binding]; other site 46234010337 structural Zn2+ binding site [ion binding]; other site 46234010338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010339 Response regulator receiver domain; Region: Response_reg; pfam00072 46234010340 active site 46234010341 intermolecular recognition site; other site 46234010342 dimerization interface [polypeptide binding]; other site 46234010343 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 46234010344 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 46234010345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 46234010346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 46234010347 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 46234010348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 46234010349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010350 homodimer interface [polypeptide binding]; other site 46234010351 catalytic residue [active] 46234010352 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 46234010353 IHF dimer interface [polypeptide binding]; other site 46234010354 IHF - DNA interface [nucleotide binding]; other site 46234010355 Homeodomain-like domain; Region: HTH_23; pfam13384 46234010356 Winged helix-turn helix; Region: HTH_29; pfam13551 46234010357 Homeodomain-like domain; Region: HTH_32; pfam13565 46234010358 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 46234010359 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 46234010360 metal ion-dependent adhesion site (MIDAS); other site 46234010361 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 46234010362 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 46234010363 metal ion-dependent adhesion site (MIDAS); other site 46234010364 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234010365 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234010366 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234010367 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234010368 putative active site [active] 46234010369 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 46234010370 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 46234010371 oligomer interface [polypeptide binding]; other site 46234010372 active site residues [active] 46234010373 Clp protease; Region: CLP_protease; pfam00574 46234010374 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 46234010375 oligomer interface [polypeptide binding]; other site 46234010376 active site residues [active] 46234010377 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 46234010378 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234010379 HSP70 interaction site [polypeptide binding]; other site 46234010380 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234010381 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 46234010382 pheophorbide a oxygenase; Region: PLN02518 46234010383 iron-sulfur cluster [ion binding]; other site 46234010384 [2Fe-2S] cluster binding site [ion binding]; other site 46234010385 Pheophorbide a oxygenase; Region: PaO; pfam08417 46234010386 AAA ATPase domain; Region: AAA_16; pfam13191 46234010387 AAA domain; Region: AAA_14; pfam13173 46234010388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010389 binding surface 46234010390 TPR motif; other site 46234010391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 46234010393 TPR repeat; Region: TPR_11; pfam13414 46234010394 binding surface 46234010395 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234010396 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 46234010397 putative ligand binding site [chemical binding]; other site 46234010398 AAA ATPase domain; Region: AAA_16; pfam13191 46234010399 AAA domain; Region: AAA_22; pfam13401 46234010400 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234010401 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 46234010402 putative ligand binding site [chemical binding]; other site 46234010403 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 46234010404 MoaE interaction surface [polypeptide binding]; other site 46234010405 MoeB interaction surface [polypeptide binding]; other site 46234010406 thiocarboxylated glycine; other site 46234010407 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 46234010408 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 46234010409 active site 46234010410 metal binding site [ion binding]; metal-binding site 46234010411 DNA binding site [nucleotide binding] 46234010412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 46234010413 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 46234010414 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 46234010415 Active Sites [active] 46234010416 Repair protein; Region: Repair_PSII; pfam04536 46234010417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234010418 GAF domain; Region: GAF; pfam01590 46234010419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234010420 PAS domain; Region: PAS_9; pfam13426 46234010421 putative active site [active] 46234010422 heme pocket [chemical binding]; other site 46234010423 GAF domain; Region: GAF; cl17456 46234010424 GAF domain; Region: GAF_2; pfam13185 46234010425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 46234010426 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 46234010427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234010428 dimer interface [polypeptide binding]; other site 46234010429 phosphorylation site [posttranslational modification] 46234010430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234010431 ATP binding site [chemical binding]; other site 46234010432 Mg2+ binding site [ion binding]; other site 46234010433 G-X-G motif; other site 46234010434 Response regulator receiver domain; Region: Response_reg; pfam00072 46234010435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010436 active site 46234010437 phosphorylation site [posttranslational modification] 46234010438 intermolecular recognition site; other site 46234010439 dimerization interface [polypeptide binding]; other site 46234010440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010441 Response regulator receiver domain; Region: Response_reg; pfam00072 46234010442 active site 46234010443 phosphorylation site [posttranslational modification] 46234010444 intermolecular recognition site; other site 46234010445 dimerization interface [polypeptide binding]; other site 46234010446 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 46234010447 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 46234010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 46234010449 Protein of unknown function, DUF482; Region: DUF482; pfam04339 46234010450 RibD C-terminal domain; Region: RibD_C; cl17279 46234010451 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 46234010452 Cache domain; Region: Cache_2; cl07034 46234010453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234010454 dimer interface [polypeptide binding]; other site 46234010455 phosphorylation site [posttranslational modification] 46234010456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234010457 ATP binding site [chemical binding]; other site 46234010458 Mg2+ binding site [ion binding]; other site 46234010459 G-X-G motif; other site 46234010460 Transposase IS200 like; Region: Y1_Tnp; pfam01797 46234010461 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 46234010462 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 46234010463 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 46234010464 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 46234010465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234010466 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 46234010467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234010468 motif II; other site 46234010469 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 46234010470 recombination protein F; Reviewed; Region: recF; PRK00064 46234010471 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 46234010472 Walker A/P-loop; other site 46234010473 ATP binding site [chemical binding]; other site 46234010474 Q-loop/lid; other site 46234010475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234010476 ABC transporter signature motif; other site 46234010477 Walker B; other site 46234010478 D-loop; other site 46234010479 H-loop/switch region; other site 46234010480 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 46234010481 MgtC family; Region: MgtC; pfam02308 46234010482 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 46234010483 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 46234010484 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 46234010485 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 46234010486 shikimate kinase; Reviewed; Region: aroK; PRK00131 46234010487 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 46234010488 ADP binding site [chemical binding]; other site 46234010489 magnesium binding site [ion binding]; other site 46234010490 putative shikimate binding site; other site 46234010491 aromatic acid decarboxylase; Validated; Region: PRK05920 46234010492 Flavoprotein; Region: Flavoprotein; pfam02441 46234010493 Exoribonuclease R [Transcription]; Region: VacB; COG0557 46234010494 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 46234010495 RNB domain; Region: RNB; pfam00773 46234010496 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 46234010497 RNA binding site [nucleotide binding]; other site 46234010498 Clp protease; Region: CLP_protease; pfam00574 46234010499 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 46234010500 oligomer interface [polypeptide binding]; other site 46234010501 active site residues [active] 46234010502 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 46234010503 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 46234010504 toxin interface [polypeptide binding]; other site 46234010505 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 46234010506 Zn binding site [ion binding]; other site 46234010507 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 46234010508 active site 46234010509 catalytic residues [active] 46234010510 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 46234010511 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 46234010512 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 46234010513 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 46234010514 tetramer interface [polypeptide binding]; other site 46234010515 TPP-binding site [chemical binding]; other site 46234010516 heterodimer interface [polypeptide binding]; other site 46234010517 phosphorylation loop region [posttranslational modification] 46234010518 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 46234010519 AAA ATPase domain; Region: AAA_16; pfam13191 46234010520 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234010521 structural tetrad; other site 46234010522 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234010523 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234010524 structural tetrad; other site 46234010525 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234010526 structural tetrad; other site 46234010527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 46234010528 catalytic loop [active] 46234010529 iron binding site [ion binding]; other site 46234010530 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 46234010531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 46234010532 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010533 Transposase [DNA replication, recombination, and repair]; Region: COG5433 46234010534 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 46234010535 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 46234010536 putative active site [active] 46234010537 catalytic triad [active] 46234010538 putative dimer interface [polypeptide binding]; other site 46234010539 DNA gyrase subunit A; Validated; Region: PRK05560 46234010540 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 46234010541 CAP-like domain; other site 46234010542 active site 46234010543 primary dimer interface [polypeptide binding]; other site 46234010544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010548 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010549 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 46234010550 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 46234010551 metal-binding site [ion binding] 46234010552 TPR repeat; Region: TPR_11; pfam13414 46234010553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010554 binding surface 46234010555 TPR motif; other site 46234010556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010557 TPR repeat; Region: TPR_11; pfam13414 46234010558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010559 binding surface 46234010560 TPR motif; other site 46234010561 TPR repeat; Region: TPR_11; pfam13414 46234010562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234010563 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234010564 Probable transposase; Region: OrfB_IS605; pfam01385 46234010565 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 46234010566 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234010567 Clp protease ATP binding subunit; Region: clpC; CHL00095 46234010568 Clp amino terminal domain; Region: Clp_N; pfam02861 46234010569 Clp amino terminal domain; Region: Clp_N; pfam02861 46234010570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234010571 Walker A motif; other site 46234010572 ATP binding site [chemical binding]; other site 46234010573 Walker B motif; other site 46234010574 arginine finger; other site 46234010575 UvrB/uvrC motif; Region: UVR; pfam02151 46234010576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234010577 Walker A motif; other site 46234010578 ATP binding site [chemical binding]; other site 46234010579 Walker B motif; other site 46234010580 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 46234010581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010582 TPR motif; other site 46234010583 binding surface 46234010584 TPR repeat; Region: TPR_11; pfam13414 46234010585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010586 binding surface 46234010587 TPR motif; other site 46234010588 TPR repeat; Region: TPR_11; pfam13414 46234010589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010590 binding surface 46234010591 TPR motif; other site 46234010592 TPR repeat; Region: TPR_11; pfam13414 46234010593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010594 binding surface 46234010595 TPR motif; other site 46234010596 TPR repeat; Region: TPR_11; pfam13414 46234010597 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 46234010598 clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698 46234010599 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 46234010600 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 46234010601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 46234010602 motif II; other site 46234010603 30S ribosomal protein S1; Reviewed; Region: PRK07400 46234010604 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 46234010605 RNA binding site [nucleotide binding]; other site 46234010606 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 46234010607 RNA binding site [nucleotide binding]; other site 46234010608 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 46234010609 RNA binding site [nucleotide binding]; other site 46234010610 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 46234010611 photosystem II 47 kDa protein; Region: psbB; CHL00062 46234010612 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 46234010613 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 46234010614 putative metal binding site [ion binding]; other site 46234010615 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 46234010616 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 46234010617 putative metal binding site [ion binding]; other site 46234010618 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 46234010619 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 46234010620 active site 46234010621 active site 46234010622 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 46234010623 active site 46234010624 catalytic site [active] 46234010625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234010626 Probable transposase; Region: OrfB_IS605; pfam01385 46234010627 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234010628 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 46234010629 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 46234010630 Walker A/P-loop; other site 46234010631 ATP binding site [chemical binding]; other site 46234010632 Q-loop/lid; other site 46234010633 ABC transporter signature motif; other site 46234010634 Walker B; other site 46234010635 D-loop; other site 46234010636 H-loop/switch region; other site 46234010637 TOBE domain; Region: TOBE_2; pfam08402 46234010638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234010639 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234010640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234010641 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234010642 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 46234010643 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 46234010644 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 46234010645 GxxExxY protein; Region: GxxExxY; TIGR04256 46234010646 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 46234010647 Aluminium resistance protein; Region: Alum_res; pfam06838 46234010648 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 46234010649 Fatty acid desaturase; Region: FA_desaturase; pfam00487 46234010650 Di-iron ligands [ion binding]; other site 46234010651 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 46234010652 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 46234010653 putative di-iron ligands [ion binding]; other site 46234010654 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 46234010655 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 46234010656 putative di-iron ligands [ion binding]; other site 46234010657 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 46234010658 AMIN domain; Region: AMIN; pfam11741 46234010659 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 46234010660 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 46234010661 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 46234010662 Ligand Binding Site [chemical binding]; other site 46234010663 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 46234010664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234010665 Walker A/P-loop; other site 46234010666 ATP binding site [chemical binding]; other site 46234010667 Q-loop/lid; other site 46234010668 ABC transporter signature motif; other site 46234010669 Walker B; other site 46234010670 D-loop; other site 46234010671 H-loop/switch region; other site 46234010672 ABC transporter; Region: ABC_tran_2; pfam12848 46234010673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 46234010674 MASE1; Region: MASE1; pfam05231 46234010675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234010676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234010677 dimer interface [polypeptide binding]; other site 46234010678 phosphorylation site [posttranslational modification] 46234010679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234010680 ATP binding site [chemical binding]; other site 46234010681 Mg2+ binding site [ion binding]; other site 46234010682 G-X-G motif; other site 46234010683 Response regulator receiver domain; Region: Response_reg; pfam00072 46234010684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010685 active site 46234010686 phosphorylation site [posttranslational modification] 46234010687 intermolecular recognition site; other site 46234010688 dimerization interface [polypeptide binding]; other site 46234010689 Class I aldolases; Region: Aldolase_Class_I; cl17187 46234010690 catalytic residue [active] 46234010691 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 46234010692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 46234010693 putative substrate translocation pore; other site 46234010694 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 46234010695 TrkA-N domain; Region: TrkA_N; pfam02254 46234010696 Ion channel; Region: Ion_trans_2; pfam07885 46234010697 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 46234010698 TrkA-N domain; Region: TrkA_N; pfam02254 46234010699 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 46234010700 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 46234010701 putative methyltransferase; Provisional; Region: PRK11524 46234010702 Predicted membrane protein [Function unknown]; Region: COG1981 46234010703 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 46234010704 RNA binding site [nucleotide binding]; other site 46234010705 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 46234010706 active site 46234010707 dimer interface [polypeptide binding]; other site 46234010708 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 46234010709 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 46234010710 active site 46234010711 HIGH motif; other site 46234010712 dimer interface [polypeptide binding]; other site 46234010713 KMSKS motif; other site 46234010714 Transglycosylase; Region: Transgly; pfam00912 46234010715 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 46234010716 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 46234010717 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 46234010718 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 46234010719 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 46234010720 putative active site [active] 46234010721 putative NTP binding site [chemical binding]; other site 46234010722 putative nucleic acid binding site [nucleotide binding]; other site 46234010723 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 46234010724 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234010725 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 46234010726 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234010727 HSP70 interaction site [polypeptide binding]; other site 46234010728 TPR repeat; Region: TPR_11; pfam13414 46234010729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010730 binding surface 46234010731 TPR motif; other site 46234010732 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 46234010733 Short C-terminal domain; Region: SHOCT; pfam09851 46234010734 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 46234010735 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 46234010736 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 46234010737 Catalytic site [active] 46234010738 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 46234010739 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 46234010740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 46234010741 threonine synthase; Validated; Region: PRK07591 46234010742 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 46234010743 homodimer interface [polypeptide binding]; other site 46234010744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010745 catalytic residue [active] 46234010746 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 46234010747 MoaE interaction surface [polypeptide binding]; other site 46234010748 MoeB interaction surface [polypeptide binding]; other site 46234010749 thiocarboxylated glycine; other site 46234010750 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 46234010751 TM2 domain; Region: TM2; cl00984 46234010752 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 46234010753 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 46234010754 FMN binding site [chemical binding]; other site 46234010755 active site 46234010756 catalytic residues [active] 46234010757 substrate binding site [chemical binding]; other site 46234010758 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 46234010759 hypothetical protein; Provisional; Region: PRK07377 46234010760 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 46234010761 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 46234010762 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 46234010763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234010764 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 46234010765 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 46234010766 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 46234010767 homodimer interface [polypeptide binding]; other site 46234010768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010769 catalytic residue [active] 46234010770 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 46234010771 Protein of unknown function DUF262; Region: DUF262; pfam03235 46234010772 GTP-binding protein YchF; Reviewed; Region: PRK09601 46234010773 YchF GTPase; Region: YchF; cd01900 46234010774 G1 box; other site 46234010775 GTP/Mg2+ binding site [chemical binding]; other site 46234010776 Switch I region; other site 46234010777 G2 box; other site 46234010778 Switch II region; other site 46234010779 G3 box; other site 46234010780 G4 box; other site 46234010781 G5 box; other site 46234010782 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 46234010783 arogenate dehydrogenase; Reviewed; Region: PRK07417 46234010784 prephenate dehydrogenase; Validated; Region: PRK08507 46234010785 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 46234010786 Peptidase family M23; Region: Peptidase_M23; pfam01551 46234010787 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 46234010788 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 46234010789 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 46234010790 active site 46234010791 homodimer interface [polypeptide binding]; other site 46234010792 CHAT domain; Region: CHAT; cl17868 46234010793 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 46234010794 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 46234010795 putative ligand binding site [chemical binding]; other site 46234010796 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 46234010797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010798 TPR repeat; Region: TPR_11; pfam13414 46234010799 binding surface 46234010800 TPR motif; other site 46234010801 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 46234010802 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 46234010803 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 46234010804 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 46234010805 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 46234010806 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 46234010807 putative dimer interface [polypeptide binding]; other site 46234010808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 46234010809 Histidine kinase; Region: HisKA_3; pfam07730 46234010810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234010811 ATP binding site [chemical binding]; other site 46234010812 Mg2+ binding site [ion binding]; other site 46234010813 G-X-G motif; other site 46234010814 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 46234010815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010816 active site 46234010817 phosphorylation site [posttranslational modification] 46234010818 intermolecular recognition site; other site 46234010819 dimerization interface [polypeptide binding]; other site 46234010820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 46234010821 DNA binding residues [nucleotide binding] 46234010822 dimerization interface [polypeptide binding]; other site 46234010823 DNA primase; Validated; Region: dnaG; PRK05667 46234010824 CHC2 zinc finger; Region: zf-CHC2; pfam01807 46234010825 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 46234010826 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 46234010827 active site 46234010828 metal binding site [ion binding]; metal-binding site 46234010829 interdomain interaction site; other site 46234010830 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 46234010831 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 46234010832 putative valine binding site [chemical binding]; other site 46234010833 dimer interface [polypeptide binding]; other site 46234010834 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 46234010835 hydrolase, alpha/beta fold family protein; Region: PLN02824 46234010836 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 46234010837 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 46234010838 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 46234010839 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 46234010840 Phycobilisome protein; Region: Phycobilisome; cl08227 46234010841 Phycobilisome protein; Region: Phycobilisome; cl08227 46234010842 phycobillisome linker protein; Region: apcE; CHL00091 46234010843 Phycobilisome protein; Region: Phycobilisome; cl08227 46234010844 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234010845 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234010846 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234010847 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 46234010848 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234010849 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 46234010850 putative NAD(P) binding site [chemical binding]; other site 46234010851 active site 46234010852 putative substrate binding site [chemical binding]; other site 46234010853 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 46234010854 core domain interface [polypeptide binding]; other site 46234010855 delta subunit interface [polypeptide binding]; other site 46234010856 epsilon subunit interface [polypeptide binding]; other site 46234010857 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 46234010858 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 46234010859 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 46234010860 beta subunit interaction interface [polypeptide binding]; other site 46234010861 Walker A motif; other site 46234010862 ATP binding site [chemical binding]; other site 46234010863 Walker B motif; other site 46234010864 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 46234010865 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 46234010866 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 46234010867 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 46234010868 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 46234010869 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 46234010870 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 46234010871 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 46234010872 ATP synthase CF0 A subunit; Region: atpI; CHL00046 46234010873 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 46234010874 ATP synthase I chain; Region: ATP_synt_I; pfam03899 46234010875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234010876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234010877 S-adenosylmethionine binding site [chemical binding]; other site 46234010878 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 46234010879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 46234010880 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 46234010881 substrate binding pocket [chemical binding]; other site 46234010882 membrane-bound complex binding site; other site 46234010883 hinge residues; other site 46234010884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 46234010885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234010886 dimer interface [polypeptide binding]; other site 46234010887 conserved gate region; other site 46234010888 putative PBP binding loops; other site 46234010889 ABC-ATPase subunit interface; other site 46234010890 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 46234010891 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 46234010892 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 46234010893 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 46234010894 phytoene desaturase; Region: phytoene_desat; TIGR02731 46234010895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 46234010896 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 46234010897 active site lid residues [active] 46234010898 substrate binding pocket [chemical binding]; other site 46234010899 catalytic residues [active] 46234010900 substrate-Mg2+ binding site; other site 46234010901 aspartate-rich region 1; other site 46234010902 aspartate-rich region 2; other site 46234010903 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 46234010904 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 46234010905 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 46234010906 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 46234010907 dimer interface [polypeptide binding]; other site 46234010908 [2Fe-2S] cluster binding site [ion binding]; other site 46234010909 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 46234010910 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 46234010911 dimer interface [polypeptide binding]; other site 46234010912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 46234010913 catalytic residue [active] 46234010914 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 46234010915 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 46234010916 Walker A/P-loop; other site 46234010917 ATP binding site [chemical binding]; other site 46234010918 Q-loop/lid; other site 46234010919 ABC transporter signature motif; other site 46234010920 Walker B; other site 46234010921 D-loop; other site 46234010922 H-loop/switch region; other site 46234010923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 46234010924 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 46234010925 Walker A/P-loop; other site 46234010926 ATP binding site [chemical binding]; other site 46234010927 Q-loop/lid; other site 46234010928 ABC transporter signature motif; other site 46234010929 Walker B; other site 46234010930 D-loop; other site 46234010931 H-loop/switch region; other site 46234010932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 46234010933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234010935 binding surface 46234010936 TPR motif; other site 46234010937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234010938 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 46234010939 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 46234010940 ThiS interaction site; other site 46234010941 putative active site [active] 46234010942 tetramer interface [polypeptide binding]; other site 46234010943 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 46234010944 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 46234010945 active site 46234010946 catalytic residues [active] 46234010947 metal binding site [ion binding]; metal-binding site 46234010948 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 46234010949 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 46234010950 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 46234010951 putative NAD(P) binding site [chemical binding]; other site 46234010952 catalytic Zn binding site [ion binding]; other site 46234010953 structural Zn binding site [ion binding]; other site 46234010954 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 46234010955 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 46234010956 active site 46234010957 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 46234010958 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 46234010959 BolA-like protein; Region: BolA; pfam01722 46234010960 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 46234010961 putative GSH binding site [chemical binding]; other site 46234010962 catalytic residues [active] 46234010963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234010964 AAA-like domain; Region: AAA_10; pfam12846 46234010965 Walker A motif; other site 46234010966 ATP binding site [chemical binding]; other site 46234010967 AAA domain; Region: AAA_11; pfam13086 46234010968 AAA domain; Region: AAA_12; pfam13087 46234010969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 46234010970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 46234010971 active site 46234010972 phosphorylation site [posttranslational modification] 46234010973 intermolecular recognition site; other site 46234010974 dimerization interface [polypeptide binding]; other site 46234010975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 46234010976 DNA binding site [nucleotide binding] 46234010977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234010978 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 46234010979 Walker A/P-loop; other site 46234010980 ATP binding site [chemical binding]; other site 46234010981 Q-loop/lid; other site 46234010982 ABC transporter signature motif; other site 46234010983 Walker B; other site 46234010984 D-loop; other site 46234010985 H-loop/switch region; other site 46234010986 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 46234010987 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 46234010988 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 46234010989 putative NADP binding site [chemical binding]; other site 46234010990 putative substrate binding site [chemical binding]; other site 46234010991 active site 46234010992 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 46234010993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234010994 FeS/SAM binding site; other site 46234010995 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 46234010996 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 46234010997 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 46234010998 dimerization interface [polypeptide binding]; other site 46234010999 DPS ferroxidase diiron center [ion binding]; other site 46234011000 ion pore; other site 46234011001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 46234011002 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 46234011003 deoxyhypusine synthase; Region: dhys; TIGR00321 46234011004 Protein of unknown function (DUF433); Region: DUF433; cl01030 46234011005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 46234011006 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 46234011007 Protein of unknown function (DUF433); Region: DUF433; pfam04255 46234011008 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 46234011009 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 46234011010 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 46234011011 homodimer interface [polypeptide binding]; other site 46234011012 Walker A motif; other site 46234011013 ATP binding site [chemical binding]; other site 46234011014 hydroxycobalamin binding site [chemical binding]; other site 46234011015 Walker B motif; other site 46234011016 RNA polymerase sigma factor; Validated; Region: PRK05949 46234011017 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 46234011018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234011019 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 46234011020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234011021 DNA binding residues [nucleotide binding] 46234011022 HAS barrel domain; Region: HAS-barrel; pfam09378 46234011023 HerA helicase [Replication, recombination, and repair]; Region: COG0433 46234011024 Domain of unknown function DUF87; Region: DUF87; pfam01935 46234011025 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 46234011026 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 46234011027 C-terminal domain interface [polypeptide binding]; other site 46234011028 GSH binding site (G-site) [chemical binding]; other site 46234011029 dimer interface [polypeptide binding]; other site 46234011030 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 46234011031 N-terminal domain interface [polypeptide binding]; other site 46234011032 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 46234011033 Fasciclin domain; Region: Fasciclin; pfam02469 46234011034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 46234011035 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 46234011036 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 46234011037 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 46234011038 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 46234011039 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 46234011040 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 46234011041 catalytic residues [active] 46234011042 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 46234011043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 46234011044 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 46234011045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234011046 ATP binding site [chemical binding]; other site 46234011047 putative Mg++ binding site [ion binding]; other site 46234011048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 46234011049 nucleotide binding region [chemical binding]; other site 46234011050 ATP-binding site [chemical binding]; other site 46234011051 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 46234011052 HRDC domain; Region: HRDC; pfam00570 46234011053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 46234011054 DNA binding residues [nucleotide binding] 46234011055 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 46234011056 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 46234011057 acyl-activating enzyme (AAE) consensus motif; other site 46234011058 putative AMP binding site [chemical binding]; other site 46234011059 putative active site [active] 46234011060 putative CoA binding site [chemical binding]; other site 46234011061 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 46234011062 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 46234011063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 46234011064 E3 interaction surface; other site 46234011065 lipoyl attachment site [posttranslational modification]; other site 46234011066 e3 binding domain; Region: E3_binding; pfam02817 46234011067 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 46234011068 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234011069 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234011070 catalytic residues [active] 46234011071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 46234011072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234011073 NAD(P) binding site [chemical binding]; other site 46234011074 active site 46234011075 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234011076 YcfA-like protein; Region: YcfA; pfam07927 46234011077 molecular chaperone DnaK; Provisional; Region: PRK13410 46234011078 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 46234011079 nucleotide binding site [chemical binding]; other site 46234011080 NEF interaction site [polypeptide binding]; other site 46234011081 SBD interface [polypeptide binding]; other site 46234011082 chaperone protein DnaJ; Provisional; Region: PRK14277 46234011083 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234011084 HSP70 interaction site [polypeptide binding]; other site 46234011085 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 46234011086 substrate binding site [polypeptide binding]; other site 46234011087 dimer interface [polypeptide binding]; other site 46234011088 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011089 putative active site [active] 46234011090 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 46234011091 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 46234011092 HSP70 interaction site [polypeptide binding]; other site 46234011093 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 46234011094 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 46234011095 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 46234011096 catalytic residue [active] 46234011097 putative FPP diphosphate binding site; other site 46234011098 putative FPP binding hydrophobic cleft; other site 46234011099 dimer interface [polypeptide binding]; other site 46234011100 putative IPP diphosphate binding site; other site 46234011101 Uncharacterized conserved protein [Function unknown]; Region: COG1624 46234011102 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 46234011103 diaminopimelate decarboxylase; Region: lysA; TIGR01048 46234011104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 46234011105 active site 46234011106 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 46234011107 substrate binding site [chemical binding]; other site 46234011108 catalytic residues [active] 46234011109 dimer interface [polypeptide binding]; other site 46234011110 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 46234011111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234011112 Coenzyme A binding pocket [chemical binding]; other site 46234011113 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 46234011114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 46234011115 Mg2+ binding site [ion binding]; other site 46234011116 G-X-G motif; other site 46234011117 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 46234011118 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 46234011119 interchain domain interface [polypeptide binding]; other site 46234011120 intrachain domain interface; other site 46234011121 Qi binding site; other site 46234011122 Qo binding site; other site 46234011123 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 46234011124 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 46234011125 Qi binding site; other site 46234011126 intrachain domain interface; other site 46234011127 interchain domain interface [polypeptide binding]; other site 46234011128 heme bH binding site [chemical binding]; other site 46234011129 heme bL binding site [chemical binding]; other site 46234011130 Qo binding site; other site 46234011131 carboxyl-terminal processing protease; Provisional; Region: PLN00049 46234011132 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 46234011133 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 46234011134 protein binding site [polypeptide binding]; other site 46234011135 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 46234011136 Catalytic dyad [active] 46234011137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 46234011138 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 46234011139 Peptidase family M50; Region: Peptidase_M50; pfam02163 46234011140 active site 46234011141 putative substrate binding region [chemical binding]; other site 46234011142 CpeS-like protein; Region: CpeS; pfam09367 46234011143 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 46234011144 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 46234011145 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234011146 cofactor binding site; other site 46234011147 DNA binding site [nucleotide binding] 46234011148 substrate interaction site [chemical binding]; other site 46234011149 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234011150 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 46234011151 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 46234011152 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 46234011153 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 46234011154 active site 46234011155 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 46234011156 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 46234011157 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 46234011158 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 46234011159 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 46234011160 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 46234011161 Surface antigen; Region: Bac_surface_Ag; pfam01103 46234011162 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 46234011163 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 46234011164 ATP binding site [chemical binding]; other site 46234011165 active site 46234011166 substrate binding site [chemical binding]; other site 46234011167 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 46234011168 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 46234011169 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 46234011170 substrate binding pocket [chemical binding]; other site 46234011171 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 46234011172 B12 binding site [chemical binding]; other site 46234011173 cobalt ligand [ion binding]; other site 46234011174 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 46234011175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234011176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234011177 active site 46234011178 ATP binding site [chemical binding]; other site 46234011179 substrate binding site [chemical binding]; other site 46234011180 activation loop (A-loop); other site 46234011181 KWG Leptospira; Region: KWG; pfam07656 46234011182 Uncharacterized conserved protein [Function unknown]; Region: COG5464 46234011183 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234011184 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 46234011185 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011186 putative active site [active] 46234011187 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011188 putative active site [active] 46234011189 Uncharacterized conserved protein [Function unknown]; Region: COG1434 46234011190 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 46234011191 putative active site [active] 46234011192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 46234011193 Predicted kinase [General function prediction only]; Region: COG0645 46234011194 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 46234011195 ATP-binding site [chemical binding]; other site 46234011196 Gluconate-6-phosphate binding site [chemical binding]; other site 46234011197 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 46234011198 5S rRNA interface [nucleotide binding]; other site 46234011199 CTC domain interface [polypeptide binding]; other site 46234011200 L16 interface [polypeptide binding]; other site 46234011201 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 46234011202 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 46234011203 GDP-binding site [chemical binding]; other site 46234011204 ACT binding site; other site 46234011205 IMP binding site; other site 46234011206 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 46234011207 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 46234011208 cytochrome c6; Provisional; Region: PRK13697 46234011209 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 46234011210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234011211 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 46234011212 Coenzyme A binding pocket [chemical binding]; other site 46234011213 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 46234011214 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 46234011215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 46234011216 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 46234011217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 46234011218 DNA binding residues [nucleotide binding] 46234011219 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 46234011220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 46234011221 ATP binding site [chemical binding]; other site 46234011222 putative Mg++ binding site [ion binding]; other site 46234011223 helicase superfamily c-terminal domain; Region: HELICc; smart00490 46234011224 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 46234011225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234011226 binding surface 46234011227 TPR motif; other site 46234011228 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 46234011229 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 46234011230 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 46234011231 nucleotide binding site [chemical binding]; other site 46234011232 NEF interaction site [polypeptide binding]; other site 46234011233 SBD interface [polypeptide binding]; other site 46234011234 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 46234011235 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 46234011236 pseudouridine synthase; Region: TIGR00093 46234011237 probable active site [active] 46234011238 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 46234011239 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 46234011240 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 46234011241 active site 46234011242 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234011243 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234011244 phosphopeptide binding site; other site 46234011245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234011246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234011247 active site 46234011248 ATP binding site [chemical binding]; other site 46234011249 substrate binding site [chemical binding]; other site 46234011250 activation loop (A-loop); other site 46234011251 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 46234011252 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 46234011253 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 46234011254 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 46234011255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 46234011256 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 46234011257 Soluble P-type ATPase [General function prediction only]; Region: COG4087 46234011258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 46234011259 BON domain; Region: BON; cl02771 46234011260 CsbD-like; Region: CsbD; cl17424 46234011261 PRC-barrel domain; Region: PRC; pfam05239 46234011262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 46234011263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234011264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234011265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234011266 Walker A/P-loop; other site 46234011267 ATP binding site [chemical binding]; other site 46234011268 Q-loop/lid; other site 46234011269 ABC transporter signature motif; other site 46234011270 Walker B; other site 46234011271 D-loop; other site 46234011272 H-loop/switch region; other site 46234011273 HupE / UreJ protein; Region: HupE_UreJ; cl01011 46234011274 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 46234011275 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 46234011276 DHH family; Region: DHH; pfam01368 46234011277 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 46234011278 RloB-like protein; Region: RloB; pfam13707 46234011279 AAA domain; Region: AAA_21; pfam13304 46234011280 Predicted membrane protein [Function unknown]; Region: COG2119 46234011281 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 46234011282 Predicted membrane protein [Function unknown]; Region: COG2119 46234011283 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 46234011284 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 46234011285 putative di-iron ligands [ion binding]; other site 46234011286 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 46234011287 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 46234011288 MutS domain I; Region: MutS_I; pfam01624 46234011289 MutS domain II; Region: MutS_II; pfam05188 46234011290 MutS domain III; Region: MutS_III; pfam05192 46234011291 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 46234011292 Walker A/P-loop; other site 46234011293 ATP binding site [chemical binding]; other site 46234011294 Q-loop/lid; other site 46234011295 ABC transporter signature motif; other site 46234011296 Walker B; other site 46234011297 D-loop; other site 46234011298 H-loop/switch region; other site 46234011299 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 46234011300 CHASE2 domain; Region: CHASE2; pfam05226 46234011301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 46234011302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 46234011303 metal binding site [ion binding]; metal-binding site 46234011304 active site 46234011305 I-site; other site 46234011306 FecR protein; Region: FecR; pfam04773 46234011307 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234011308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011310 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234011311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011312 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 46234011313 ATP-grasp domain; Region: ATP-grasp; pfam02222 46234011314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234011315 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 46234011316 Probable transposase; Region: OrfB_IS605; pfam01385 46234011317 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 46234011318 ribosome maturation protein RimP; Reviewed; Region: PRK00092 46234011319 Sm and related proteins; Region: Sm_like; cl00259 46234011320 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 46234011321 putative oligomer interface [polypeptide binding]; other site 46234011322 putative RNA binding site [nucleotide binding]; other site 46234011323 NusA N-terminal domain; Region: NusA_N; pfam08529 46234011324 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 46234011325 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 46234011326 RNA binding site [nucleotide binding]; other site 46234011327 homodimer interface [polypeptide binding]; other site 46234011328 NusA-like KH domain; Region: KH_5; pfam13184 46234011329 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 46234011330 G-X-X-G motif; other site 46234011331 Protein of unknown function (DUF448); Region: DUF448; pfam04296 46234011332 putative RNA binding cleft [nucleotide binding]; other site 46234011333 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 46234011334 translation initiation factor IF-2; Region: IF-2; TIGR00487 46234011335 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 46234011336 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 46234011337 G1 box; other site 46234011338 putative GEF interaction site [polypeptide binding]; other site 46234011339 GTP/Mg2+ binding site [chemical binding]; other site 46234011340 Switch I region; other site 46234011341 G2 box; other site 46234011342 G3 box; other site 46234011343 Switch II region; other site 46234011344 G4 box; other site 46234011345 G5 box; other site 46234011346 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 46234011347 Translation-initiation factor 2; Region: IF-2; pfam11987 46234011348 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 46234011349 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 46234011350 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 46234011351 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 46234011352 S-layer homology domain; Region: SLH; pfam00395 46234011353 S-layer homology domain; Region: SLH; pfam00395 46234011354 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 46234011355 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011356 putative active site [active] 46234011357 pantothenate kinase; Reviewed; Region: PRK13331 46234011358 GTP-binding protein LepA; Provisional; Region: PRK05433 46234011359 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 46234011360 G1 box; other site 46234011361 putative GEF interaction site [polypeptide binding]; other site 46234011362 GTP/Mg2+ binding site [chemical binding]; other site 46234011363 Switch I region; other site 46234011364 G2 box; other site 46234011365 G3 box; other site 46234011366 Switch II region; other site 46234011367 G4 box; other site 46234011368 G5 box; other site 46234011369 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 46234011370 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 46234011371 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 46234011372 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 46234011373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234011374 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 46234011375 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 46234011376 proposed catalytic triad [active] 46234011377 active site nucleophile [active] 46234011378 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 46234011379 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 46234011380 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 46234011381 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 46234011382 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 46234011383 active site 46234011384 substrate binding site [chemical binding]; other site 46234011385 metal binding site [ion binding]; metal-binding site 46234011386 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 46234011387 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 46234011388 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 46234011389 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 46234011390 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 46234011391 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 46234011392 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 46234011393 dimerization interface [polypeptide binding]; other site 46234011394 active site 46234011395 metal binding site [ion binding]; metal-binding site 46234011396 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 46234011397 dsRNA binding site [nucleotide binding]; other site 46234011398 AAA domain; Region: AAA_21; pfam13304 46234011399 GxxExxY protein; Region: GxxExxY; TIGR04256 46234011400 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 46234011401 Transglycosylase; Region: Transgly; pfam00912 46234011402 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 46234011403 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 46234011404 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 46234011405 Bacterial Ig-like domain; Region: Big_5; pfam13205 46234011406 MG2 domain; Region: A2M_N; pfam01835 46234011407 Alpha-2-macroglobulin family; Region: A2M; pfam00207 46234011408 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 46234011409 specificity defining residues; other site 46234011410 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 46234011411 Domain of unknown function DUF21; Region: DUF21; pfam01595 46234011412 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 46234011413 Transporter associated domain; Region: CorC_HlyC; smart01091 46234011414 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 46234011415 active site 46234011416 dimerization interface [polypeptide binding]; other site 46234011417 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011418 putative active site [active] 46234011419 light-harvesting-like protein 3; Provisional; Region: PLN00014 46234011420 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 46234011421 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 46234011422 hexamer interface [polypeptide binding]; other site 46234011423 ligand binding site [chemical binding]; other site 46234011424 putative active site [active] 46234011425 NAD(P) binding site [chemical binding]; other site 46234011426 MAPEG family; Region: MAPEG; pfam01124 46234011427 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 46234011428 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 46234011429 Walker A/P-loop; other site 46234011430 ATP binding site [chemical binding]; other site 46234011431 Q-loop/lid; other site 46234011432 ABC transporter signature motif; other site 46234011433 Walker B; other site 46234011434 D-loop; other site 46234011435 H-loop/switch region; other site 46234011436 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 46234011437 mce related protein; Region: MCE; pfam02470 46234011438 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 46234011439 Clp protease ATP binding subunit; Region: clpC; CHL00095 46234011440 Clp amino terminal domain; Region: Clp_N; pfam02861 46234011441 Clp amino terminal domain; Region: Clp_N; pfam02861 46234011442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234011443 Walker A motif; other site 46234011444 ATP binding site [chemical binding]; other site 46234011445 Walker B motif; other site 46234011446 arginine finger; other site 46234011447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234011448 Walker A motif; other site 46234011449 ATP binding site [chemical binding]; other site 46234011450 Walker B motif; other site 46234011451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 46234011452 PIN domain; Region: PIN_3; pfam13470 46234011453 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 46234011454 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 46234011455 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 46234011456 ribosomal protein L33; Region: rpl33; CHL00104 46234011457 ribosomal protein S18; Region: rps18; CHL00077 46234011458 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 46234011459 RNB domain; Region: RNB; pfam00773 46234011460 RRXRR protein; Region: RRXRR; pfam14239 46234011461 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 46234011462 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234011463 active site 46234011464 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 46234011465 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 46234011466 active site 46234011467 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 46234011468 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 46234011469 C-terminal domain interface [polypeptide binding]; other site 46234011470 active site 46234011471 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 46234011472 active site 46234011473 N-terminal domain interface [polypeptide binding]; other site 46234011474 Domain of unknown function DUF29; Region: DUF29; pfam01724 46234011475 Outer membrane efflux protein; Region: OEP; pfam02321 46234011476 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 46234011477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234011478 Walker A motif; other site 46234011479 ATP binding site [chemical binding]; other site 46234011480 Walker B motif; other site 46234011481 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 46234011482 RxxxH motif; other site 46234011483 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 46234011484 4Fe-4S binding domain; Region: Fer4; pfam00037 46234011485 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 46234011486 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 46234011487 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 46234011488 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 46234011489 nucleotide binding site [chemical binding]; other site 46234011490 putative NEF/HSP70 interaction site [polypeptide binding]; other site 46234011491 SBD interface [polypeptide binding]; other site 46234011492 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 46234011493 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 46234011494 putative lipid kinase; Reviewed; Region: PRK13057 46234011495 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234011496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234011497 S-adenosylmethionine binding site [chemical binding]; other site 46234011498 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 46234011499 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 46234011500 Walker A/P-loop; other site 46234011501 ATP binding site [chemical binding]; other site 46234011502 Q-loop/lid; other site 46234011503 ABC transporter signature motif; other site 46234011504 Walker B; other site 46234011505 D-loop; other site 46234011506 H-loop/switch region; other site 46234011507 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 46234011508 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 46234011509 Walker A/P-loop; other site 46234011510 ATP binding site [chemical binding]; other site 46234011511 Q-loop/lid; other site 46234011512 ABC transporter signature motif; other site 46234011513 Walker B; other site 46234011514 D-loop; other site 46234011515 H-loop/switch region; other site 46234011516 NMT1-like family; Region: NMT1_2; pfam13379 46234011517 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 46234011518 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 46234011519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234011520 dimer interface [polypeptide binding]; other site 46234011521 conserved gate region; other site 46234011522 putative PBP binding loops; other site 46234011523 ABC-ATPase subunit interface; other site 46234011524 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 46234011525 NMT1-like family; Region: NMT1_2; pfam13379 46234011526 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 46234011527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234011528 dimer interface [polypeptide binding]; other site 46234011529 conserved gate region; other site 46234011530 putative PBP binding loops; other site 46234011531 ABC-ATPase subunit interface; other site 46234011532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 46234011533 dimer interface [polypeptide binding]; other site 46234011534 conserved gate region; other site 46234011535 putative PBP binding loops; other site 46234011536 ABC-ATPase subunit interface; other site 46234011537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 46234011538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 46234011539 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 46234011540 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 46234011541 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 46234011542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011543 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234011544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011545 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011546 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234011547 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011548 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 46234011549 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 46234011550 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 46234011551 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 46234011552 active site 46234011553 SAM binding site [chemical binding]; other site 46234011554 homodimer interface [polypeptide binding]; other site 46234011555 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 46234011556 active site 46234011557 SAM binding site [chemical binding]; other site 46234011558 homodimer interface [polypeptide binding]; other site 46234011559 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 46234011560 Precorrin-8X methylmutase; Region: CbiC; pfam02570 46234011561 precorrin-3B synthase; Region: CobG; TIGR02435 46234011562 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234011563 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 46234011564 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 46234011565 active site 46234011566 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 46234011567 active site 46234011568 putative homodimer interface [polypeptide binding]; other site 46234011569 SAM binding site [chemical binding]; other site 46234011570 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 46234011571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234011572 S-adenosylmethionine binding site [chemical binding]; other site 46234011573 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 46234011574 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 46234011575 alpha subunit interface [polypeptide binding]; other site 46234011576 TPP binding site [chemical binding]; other site 46234011577 heterodimer interface [polypeptide binding]; other site 46234011578 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 46234011579 protein-export membrane protein SecD; Region: secD; TIGR01129 46234011580 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 46234011581 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 46234011582 Protein export membrane protein; Region: SecD_SecF; pfam02355 46234011583 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 46234011584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 46234011585 Coenzyme A binding pocket [chemical binding]; other site 46234011586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234011587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234011588 dimer interface [polypeptide binding]; other site 46234011589 phosphorylation site [posttranslational modification] 46234011590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 46234011591 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 46234011592 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 46234011593 active site 46234011594 NTP binding site [chemical binding]; other site 46234011595 metal binding triad [ion binding]; metal-binding site 46234011596 antibiotic binding site [chemical binding]; other site 46234011597 HEPN domain; Region: HEPN; cl00824 46234011598 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 46234011599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234011600 NAD(P) binding site [chemical binding]; other site 46234011601 active site 46234011602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234011603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234011604 active site 46234011605 ATP binding site [chemical binding]; other site 46234011606 substrate binding site [chemical binding]; other site 46234011607 activation loop (A-loop); other site 46234011608 GUN4-like; Region: GUN4; pfam05419 46234011609 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 46234011610 substrate binding site [chemical binding]; other site 46234011611 active site 46234011612 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 46234011613 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 46234011614 oligomer interface [polypeptide binding]; other site 46234011615 metal binding site [ion binding]; metal-binding site 46234011616 metal binding site [ion binding]; metal-binding site 46234011617 Cl binding site [ion binding]; other site 46234011618 aspartate ring; other site 46234011619 basic sphincter; other site 46234011620 putative hydrophobic gate; other site 46234011621 periplasmic entrance; other site 46234011622 BON domain; Region: BON; cl02771 46234011623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234011624 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 46234011625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 46234011626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 46234011627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 46234011628 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 46234011629 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 46234011630 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234011631 oligomeric interface; other site 46234011632 putative active site [active] 46234011633 homodimer interface [polypeptide binding]; other site 46234011634 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 46234011635 oligomeric interface; other site 46234011636 putative active site [active] 46234011637 homodimer interface [polypeptide binding]; other site 46234011638 ent-kaur-16-ene synthase; Region: PLN02279 46234011639 Barstar (barnase inhibitor); Region: Barstar; pfam01337 46234011640 RNAase interaction site [polypeptide binding]; other site 46234011641 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 46234011642 substrate binding site [chemical binding]; other site 46234011643 FOG: WD40 repeat [General function prediction only]; Region: COG2319 46234011644 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 46234011645 structural tetrad; other site 46234011646 Protein phosphatase 2C; Region: PP2C_2; pfam13672 46234011647 active site 46234011648 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 46234011649 metal ion-dependent adhesion site (MIDAS); other site 46234011650 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 46234011651 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 46234011652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 46234011653 active site 46234011654 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 46234011655 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 46234011656 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 46234011657 Walker A/P-loop; other site 46234011658 ATP binding site [chemical binding]; other site 46234011659 Q-loop/lid; other site 46234011660 ABC transporter signature motif; other site 46234011661 Walker B; other site 46234011662 D-loop; other site 46234011663 H-loop/switch region; other site 46234011664 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 46234011665 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 46234011666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234011667 Walker A/P-loop; other site 46234011668 ATP binding site [chemical binding]; other site 46234011669 Q-loop/lid; other site 46234011670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 46234011671 ABC transporter signature motif; other site 46234011672 Walker B; other site 46234011673 D-loop; other site 46234011674 ABC transporter; Region: ABC_tran_2; pfam12848 46234011675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 46234011676 Lipoxygenase; Region: Lipoxygenase; pfam00305 46234011677 Cytochrome P450; Region: p450; cl12078 46234011678 Protein of unknown function (DUF3522); Region: DUF3522; pfam12036 46234011679 Peptidase family M41; Region: Peptidase_M41; pfam01434 46234011680 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 46234011681 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 46234011682 active site 46234011683 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 46234011684 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 46234011685 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 46234011686 homotetramer interface [polypeptide binding]; other site 46234011687 FMN binding site [chemical binding]; other site 46234011688 homodimer contacts [polypeptide binding]; other site 46234011689 putative active site [active] 46234011690 putative substrate binding site [chemical binding]; other site 46234011691 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 46234011692 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 46234011693 tandem repeat interface [polypeptide binding]; other site 46234011694 oligomer interface [polypeptide binding]; other site 46234011695 active site residues [active] 46234011696 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 46234011697 tandem repeat interface [polypeptide binding]; other site 46234011698 oligomer interface [polypeptide binding]; other site 46234011699 active site residues [active] 46234011700 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 46234011701 DNA photolyase; Region: DNA_photolyase; pfam00875 46234011702 dihydroorotase; Provisional; Region: PRK07369 46234011703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 46234011704 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 46234011705 active site 46234011706 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 46234011707 PHP domain; Region: PHP; pfam02811 46234011708 active site 46234011709 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 46234011710 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 46234011711 dimerization interface [polypeptide binding]; other site 46234011712 putative ATP binding site [chemical binding]; other site 46234011713 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 46234011714 dimerization interface [polypeptide binding]; other site 46234011715 active site 46234011716 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 46234011717 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 46234011718 trimer interface [polypeptide binding]; other site 46234011719 active site 46234011720 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 46234011721 trimer interface [polypeptide binding]; other site 46234011722 active site 46234011723 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 46234011724 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 46234011725 ribonuclease PH; Reviewed; Region: rph; PRK00173 46234011726 Ribonuclease PH; Region: RNase_PH_bact; cd11362 46234011727 hexamer interface [polypeptide binding]; other site 46234011728 active site 46234011729 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 46234011730 Permease; Region: Permease; cl00510 46234011731 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 46234011732 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 46234011733 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 46234011734 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 46234011735 putative active site [active] 46234011736 Double zinc ribbon; Region: DZR; pfam12773 46234011737 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 46234011738 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 46234011739 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 46234011740 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 46234011741 phosphopeptide binding site; other site 46234011742 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 46234011743 feedback inhibition sensing region; other site 46234011744 homohexameric interface [polypeptide binding]; other site 46234011745 nucleotide binding site [chemical binding]; other site 46234011746 N-acetyl-L-glutamate binding site [chemical binding]; other site 46234011747 Tetratricopeptide repeat; Region: TPR_12; pfam13424 46234011748 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 46234011749 YtkA-like; Region: YtkA; pfam13115 46234011750 Uncharacterized conserved protein [Function unknown]; Region: COG2836 46234011751 Predicted membrane protein [Function unknown]; Region: COG2717 46234011752 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 46234011753 Catalytic domain of Protein Kinases; Region: PKc; cd00180 46234011754 active site 46234011755 ATP binding site [chemical binding]; other site 46234011756 substrate binding site [chemical binding]; other site 46234011757 activation loop (A-loop); other site 46234011758 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 46234011759 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 46234011760 G1 box; other site 46234011761 GTP/Mg2+ binding site [chemical binding]; other site 46234011762 Switch I region; other site 46234011763 G2 box; other site 46234011764 Switch II region; other site 46234011765 G3 box; other site 46234011766 G4 box; other site 46234011767 G5 box; other site 46234011768 Domain of unknown function (DUF697); Region: DUF697; pfam05128 46234011769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 46234011770 dimerization interface [polypeptide binding]; other site 46234011771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 46234011772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234011773 dimer interface [polypeptide binding]; other site 46234011774 phosphorylation site [posttranslational modification] 46234011775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234011776 ATP binding site [chemical binding]; other site 46234011777 Mg2+ binding site [ion binding]; other site 46234011778 G-X-G motif; other site 46234011779 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 46234011780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234011781 S-adenosylmethionine binding site [chemical binding]; other site 46234011782 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 46234011783 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 46234011784 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 46234011785 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 46234011786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 46234011787 NAD binding site [chemical binding]; other site 46234011788 substrate binding site [chemical binding]; other site 46234011789 active site 46234011790 proline aminopeptidase P II; Provisional; Region: PRK10879 46234011791 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 46234011792 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 46234011793 active site 46234011794 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 46234011795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234011796 S-adenosylmethionine binding site [chemical binding]; other site 46234011797 Predicted helicase [General function prediction only]; Region: COG4889 46234011798 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 46234011799 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 46234011800 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 46234011801 dimer interface [polypeptide binding]; other site 46234011802 substrate binding site [chemical binding]; other site 46234011803 ATP binding site [chemical binding]; other site 46234011804 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 46234011805 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 46234011806 intersubunit interface [polypeptide binding]; other site 46234011807 ATP-grasp domain; Region: ATP-grasp; pfam02222 46234011808 Sporulation and spore germination; Region: Germane; pfam10646 46234011809 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 46234011810 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 46234011811 carboxyltransferase (CT) interaction site; other site 46234011812 biotinylation site [posttranslational modification]; other site 46234011813 elongation factor P; Validated; Region: PRK00529 46234011814 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 46234011815 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 46234011816 RNA binding site [nucleotide binding]; other site 46234011817 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 46234011818 RNA binding site [nucleotide binding]; other site 46234011819 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 46234011820 active site 46234011821 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 46234011822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 46234011823 putative active site [active] 46234011824 putative metal binding site [ion binding]; other site 46234011825 quinolinate synthetase; Provisional; Region: PRK09375 46234011826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 46234011827 Probable transposase; Region: OrfB_IS605; pfam01385 46234011828 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 46234011829 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 46234011830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234011831 Walker A/P-loop; other site 46234011832 ATP binding site [chemical binding]; other site 46234011833 Q-loop/lid; other site 46234011834 ABC transporter signature motif; other site 46234011835 Walker B; other site 46234011836 D-loop; other site 46234011837 H-loop/switch region; other site 46234011838 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234011839 cofactor binding site; other site 46234011840 DNA binding site [nucleotide binding] 46234011841 substrate interaction site [chemical binding]; other site 46234011842 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234011843 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 46234011844 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 46234011845 cofactor binding site; other site 46234011846 DNA binding site [nucleotide binding] 46234011847 substrate interaction site [chemical binding]; other site 46234011848 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 46234011849 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 46234011850 active site 46234011851 putative substrate binding pocket [chemical binding]; other site 46234011852 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 46234011853 Subunit I/III interface [polypeptide binding]; other site 46234011854 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 46234011855 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 46234011856 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 46234011857 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 46234011858 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 46234011859 Predicted membrane protein [Function unknown]; Region: COG4244 46234011860 Predicted membrane protein [Function unknown]; Region: COG4244 46234011861 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 46234011862 dimer interface [polypeptide binding]; other site 46234011863 FMN binding site [chemical binding]; other site 46234011864 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 46234011865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 46234011866 catalytic residues [active] 46234011867 Double zinc ribbon; Region: DZR; pfam12773 46234011868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234011869 AAA domain; Region: AAA_21; pfam13304 46234011870 Walker A/P-loop; other site 46234011871 ATP binding site [chemical binding]; other site 46234011872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 46234011873 Walker B; other site 46234011874 D-loop; other site 46234011875 H-loop/switch region; other site 46234011876 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 46234011877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 46234011878 Zn2+ binding site [ion binding]; other site 46234011879 Mg2+ binding site [ion binding]; other site 46234011880 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 46234011881 synthetase active site [active] 46234011882 NTP binding site [chemical binding]; other site 46234011883 metal binding site [ion binding]; metal-binding site 46234011884 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 46234011885 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 46234011886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 46234011887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 46234011888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 46234011889 catalytic residue [active] 46234011890 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 46234011891 ATP adenylyltransferase; Region: ATP_transf; pfam09830 46234011892 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011893 putative active site [active] 46234011894 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 46234011895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 46234011898 hypothetical protein; Reviewed; Region: PRK12497 46234011899 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 46234011900 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 46234011901 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 46234011902 TrkA-N domain; Region: TrkA_N; pfam02254 46234011903 TrkA-C domain; Region: TrkA_C; pfam02080 46234011904 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011905 putative active site [active] 46234011906 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 46234011907 YcfA-like protein; Region: YcfA; pfam07927 46234011908 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 46234011909 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 46234011910 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234011911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234011912 S-adenosylmethionine binding site [chemical binding]; other site 46234011913 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 46234011914 UbiA prenyltransferase family; Region: UbiA; pfam01040 46234011915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234011916 binding surface 46234011917 Tetratricopeptide repeat; Region: TPR_16; pfam13432 46234011918 TPR motif; other site 46234011919 heat shock protein HtpX; Provisional; Region: PRK03982 46234011920 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 46234011921 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 46234011922 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 46234011923 Pheophorbide a oxygenase; Region: PaO; pfam08417 46234011924 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 46234011925 putative metal binding site [ion binding]; other site 46234011926 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 46234011927 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 46234011928 active site 46234011929 NTP binding site [chemical binding]; other site 46234011930 metal binding triad [ion binding]; metal-binding site 46234011931 antibiotic binding site [chemical binding]; other site 46234011932 HEPN domain; Region: HEPN; cl00824 46234011933 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 46234011934 classical (c) SDRs; Region: SDR_c; cd05233 46234011935 NAD(P) binding site [chemical binding]; other site 46234011936 active site 46234011937 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 46234011938 putative active site [active] 46234011939 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 46234011940 acetyl-CoA synthetase; Provisional; Region: PRK00174 46234011941 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 46234011942 active site 46234011943 CoA binding site [chemical binding]; other site 46234011944 acyl-activating enzyme (AAE) consensus motif; other site 46234011945 AMP binding site [chemical binding]; other site 46234011946 acetate binding site [chemical binding]; other site 46234011947 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 46234011948 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 46234011949 active site 46234011950 PHP Thumb interface [polypeptide binding]; other site 46234011951 metal binding site [ion binding]; metal-binding site 46234011952 C2 domain; Region: C2; cl14603 46234011953 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 46234011954 protein-splicing catalytic site; other site 46234011955 thioester formation/cholesterol transfer; other site 46234011956 Nuclease-related domain; Region: NERD; pfam08378 46234011957 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 46234011958 Family description; Region: UvrD_C_2; pfam13538 46234011959 CemA family; Region: CemA; cl03855 46234011960 MltA specific insert domain; Region: MltA; cl08398 46234011961 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 46234011962 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 46234011963 Moco binding site; other site 46234011964 metal coordination site [ion binding]; other site 46234011965 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 46234011966 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 46234011967 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 46234011968 dimerization interface [polypeptide binding]; other site 46234011969 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 46234011970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 46234011971 putative active site [active] 46234011972 heme pocket [chemical binding]; other site 46234011973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 46234011974 dimer interface [polypeptide binding]; other site 46234011975 phosphorylation site [posttranslational modification] 46234011976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 46234011977 ATP binding site [chemical binding]; other site 46234011978 Mg2+ binding site [ion binding]; other site 46234011979 G-X-G motif; other site 46234011980 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 46234011981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 46234011982 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234011983 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234011984 Hexamer interface [polypeptide binding]; other site 46234011985 Hexagonal pore residue; other site 46234011986 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 46234011987 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 46234011988 Hexamer interface [polypeptide binding]; other site 46234011989 Hexagonal pore residue; other site 46234011990 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 46234011991 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 46234011992 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 46234011993 active site 46234011994 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 46234011995 active site 46234011996 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 46234011997 active site 46234011998 MoxR-like ATPases [General function prediction only]; Region: COG0714 46234011999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 46234012000 Walker A motif; other site 46234012001 ATP binding site [chemical binding]; other site 46234012002 Walker B motif; other site 46234012003 arginine finger; other site 46234012004 AAA domain; Region: AAA_21; pfam13304 46234012005 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 46234012006 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 46234012007 active site 46234012008 Riboflavin kinase; Region: Flavokinase; pfam01687 46234012009 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 46234012010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234012011 S-adenosylmethionine binding site [chemical binding]; other site 46234012012 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 46234012013 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 46234012014 Walker A/P-loop; other site 46234012015 ATP binding site [chemical binding]; other site 46234012016 Q-loop/lid; other site 46234012017 ABC transporter signature motif; other site 46234012018 Walker B; other site 46234012019 D-loop; other site 46234012020 H-loop/switch region; other site 46234012021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234012022 binding surface 46234012023 TPR motif; other site 46234012024 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 46234012025 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 46234012026 nudix motif; other site 46234012027 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 46234012028 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 46234012029 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 46234012030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 46234012031 active site 46234012032 motif I; other site 46234012033 motif II; other site 46234012034 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 46234012035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 46234012036 Walker A/P-loop; other site 46234012037 ATP binding site [chemical binding]; other site 46234012038 Q-loop/lid; other site 46234012039 ABC transporter signature motif; other site 46234012040 Walker B; other site 46234012041 D-loop; other site 46234012042 H-loop/switch region; other site 46234012043 DevC protein; Region: devC; TIGR01185 46234012044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 46234012045 FtsX-like permease family; Region: FtsX; pfam02687 46234012046 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 46234012047 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 46234012048 HlyD family secretion protein; Region: HlyD_3; pfam13437 46234012049 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 46234012050 Maf-like protein; Region: Maf; pfam02545 46234012051 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 46234012052 active site 46234012053 dimer interface [polypeptide binding]; other site 46234012054 PsbP; Region: PsbP; pfam01789 46234012055 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 46234012056 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 46234012057 Methyltransferase domain; Region: Methyltransf_23; pfam13489 46234012058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234012059 S-adenosylmethionine binding site [chemical binding]; other site 46234012060 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 46234012061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 46234012062 FeS/SAM binding site; other site 46234012063 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 46234012064 Uncharacterized conserved protein [Function unknown]; Region: COG1262 46234012065 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 46234012066 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 46234012067 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 46234012068 Methyltransferase domain; Region: Methyltransf_31; pfam13847 46234012069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 46234012070 S-adenosylmethionine binding site [chemical binding]; other site 46234012071 Predicted membrane protein [Function unknown]; Region: COG2119 46234012072 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 46234012073 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 46234012074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234012075 TPR motif; other site 46234012076 binding surface 46234012077 TPR repeat; Region: TPR_11; pfam13414 46234012078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 46234012079 TPR motif; other site 46234012080 Domain of unknown function DUF39; Region: DUF39; pfam01837 46234012081 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 46234012082 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 46234012083 NAD binding site [chemical binding]; other site 46234012084 dimerization interface [polypeptide binding]; other site 46234012085 product binding site; other site 46234012086 substrate binding site [chemical binding]; other site 46234012087 zinc binding site [ion binding]; other site 46234012088 catalytic residues [active] 46234012089 ParG; Region: ParG; pfam09274 46234012090 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 46234012091 Part of AAA domain; Region: AAA_19; pfam13245 46234012092 Family description; Region: UvrD_C_2; pfam13538 46234012093 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 46234012094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 46234012095 active site 46234012096 DNA binding site [nucleotide binding] 46234012097 Int/Topo IB signature motif; other site 46234012098 ATPases associated with a variety of cellular activities; Region: AAA; smart00382