-- dump date 20140618_203502 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272123000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272123000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272123000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123000004 Walker A motif; other site 272123000005 ATP binding site [chemical binding]; other site 272123000006 Walker B motif; other site 272123000007 arginine finger; other site 272123000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272123000009 DnaA box-binding interface [nucleotide binding]; other site 272123000010 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272123000011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123000012 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272123000013 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 272123000014 iron-sulfur cluster [ion binding]; other site 272123000015 [2Fe-2S] cluster binding site [ion binding]; other site 272123000016 Uncharacterized conserved protein [Function unknown]; Region: COG3349 272123000017 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123000018 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272123000019 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 272123000020 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272123000021 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272123000022 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123000023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123000024 active site 272123000025 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123000026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123000027 active site 272123000028 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123000029 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 272123000030 Walker A/P-loop; other site 272123000031 ATP binding site [chemical binding]; other site 272123000032 Q-loop/lid; other site 272123000033 ABC transporter signature motif; other site 272123000034 Walker B; other site 272123000035 D-loop; other site 272123000036 H-loop/switch region; other site 272123000037 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 272123000038 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 272123000039 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272123000040 P loop; other site 272123000041 Nucleotide binding site [chemical binding]; other site 272123000042 DTAP/Switch II; other site 272123000043 Switch I; other site 272123000044 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272123000045 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000046 GAF domain; Region: GAF; pfam01590 272123000047 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000048 Phytochrome region; Region: PHY; pfam00360 272123000049 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000050 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123000051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123000052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000053 dimer interface [polypeptide binding]; other site 272123000054 phosphorylation site [posttranslational modification] 272123000055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000056 ATP binding site [chemical binding]; other site 272123000057 Mg2+ binding site [ion binding]; other site 272123000058 G-X-G motif; other site 272123000059 DNA polymerase III subunit beta; Validated; Region: PRK05643 272123000060 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272123000061 putative DNA binding surface [nucleotide binding]; other site 272123000062 dimer interface [polypeptide binding]; other site 272123000063 beta-clamp/clamp loader binding surface; other site 272123000064 beta-clamp/translesion DNA polymerase binding surface; other site 272123000065 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 272123000066 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 272123000067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123000068 BT1 family; Region: BT1; pfam03092 272123000069 putative substrate translocation pore; other site 272123000070 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272123000071 putative catalytic site [active] 272123000072 putative phosphate binding site [ion binding]; other site 272123000073 active site 272123000074 metal binding site A [ion binding]; metal-binding site 272123000075 DNA binding site [nucleotide binding] 272123000076 putative AP binding site [nucleotide binding]; other site 272123000077 putative metal binding site B [ion binding]; other site 272123000078 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123000079 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000080 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000081 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123000082 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123000083 catalytic residues [active] 272123000084 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272123000085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123000086 S-adenosylmethionine binding site [chemical binding]; other site 272123000087 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 272123000088 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272123000089 ligand binding site [chemical binding]; other site 272123000090 NAD binding site [chemical binding]; other site 272123000091 dimerization interface [polypeptide binding]; other site 272123000092 catalytic site [active] 272123000093 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 272123000094 putative L-serine binding site [chemical binding]; other site 272123000095 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123000096 putative active site [active] 272123000097 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272123000098 oligomerization interface [polypeptide binding]; other site 272123000099 active site 272123000100 metal binding site [ion binding]; metal-binding site 272123000101 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 272123000102 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 272123000103 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 272123000104 homodimer interface [polypeptide binding]; other site 272123000105 active site 272123000106 heterodimer interface [polypeptide binding]; other site 272123000107 catalytic residue [active] 272123000108 metal binding site [ion binding]; metal-binding site 272123000109 RbcX protein; Region: RcbX; pfam02341 272123000110 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 272123000111 multimerization interface [polypeptide binding]; other site 272123000112 PIN domain; Region: PIN_3; pfam13470 272123000113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272123000114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123000115 Coenzyme A binding pocket [chemical binding]; other site 272123000116 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 272123000117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123000118 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000119 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123000120 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000121 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000122 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123000123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000124 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000125 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000128 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 272123000129 active site 272123000130 catalytic triad [active] 272123000131 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123000132 putative active site [active] 272123000133 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272123000134 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272123000135 metal binding site [ion binding]; metal-binding site 272123000136 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272123000137 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272123000138 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272123000139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272123000140 ABC-ATPase subunit interface; other site 272123000141 dimer interface [polypeptide binding]; other site 272123000142 putative PBP binding regions; other site 272123000143 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 272123000144 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272123000145 putative lipid kinase; Reviewed; Region: PRK13057 272123000146 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272123000147 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272123000148 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272123000149 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272123000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123000151 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123000152 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272123000153 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272123000154 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272123000155 SnoaL-like domain; Region: SnoaL_2; pfam12680 272123000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123000157 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123000158 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 272123000159 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 272123000160 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272123000161 active site 272123000162 nucleotide binding site [chemical binding]; other site 272123000163 HIGH motif; other site 272123000164 KMSKS motif; other site 272123000165 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 272123000166 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272123000167 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 272123000168 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272123000169 dimer interface [polypeptide binding]; other site 272123000170 motif 1; other site 272123000171 active site 272123000172 motif 2; other site 272123000173 motif 3; other site 272123000174 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272123000175 anticodon binding site; other site 272123000176 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 272123000177 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 272123000178 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 272123000179 NAD(P) binding site [chemical binding]; other site 272123000180 catalytic residues [active] 272123000181 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 272123000182 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272123000183 putative active site [active] 272123000184 catalytic triad [active] 272123000185 putative dimer interface [polypeptide binding]; other site 272123000186 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272123000187 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 272123000188 tetramer interface [polypeptide binding]; other site 272123000189 active site 272123000190 Mg2+/Mn2+ binding site [ion binding]; other site 272123000191 sulfate transport protein; Provisional; Region: cysT; CHL00187 272123000192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123000193 dimer interface [polypeptide binding]; other site 272123000194 conserved gate region; other site 272123000195 putative PBP binding loops; other site 272123000196 ABC-ATPase subunit interface; other site 272123000197 sulfate transport protein; Provisional; Region: cysT; CHL00187 272123000198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123000199 dimer interface [polypeptide binding]; other site 272123000200 conserved gate region; other site 272123000201 putative PBP binding loops; other site 272123000202 ABC-ATPase subunit interface; other site 272123000203 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272123000204 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272123000205 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272123000206 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272123000207 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000209 active site 272123000210 phosphorylation site [posttranslational modification] 272123000211 intermolecular recognition site; other site 272123000212 dimerization interface [polypeptide binding]; other site 272123000213 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 272123000214 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272123000215 putative active site [active] 272123000216 putative dimer interface [polypeptide binding]; other site 272123000217 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272123000218 SelR domain; Region: SelR; pfam01641 272123000219 NACHT domain; Region: NACHT; pfam05729 272123000220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272123000221 Walker A motif; other site 272123000222 ATP binding site [chemical binding]; other site 272123000223 Walker B motif; other site 272123000224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272123000225 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272123000226 dimerization interface [polypeptide binding]; other site 272123000227 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123000228 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 272123000229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123000230 non-specific DNA binding site [nucleotide binding]; other site 272123000231 salt bridge; other site 272123000232 sequence-specific DNA binding site [nucleotide binding]; other site 272123000233 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 272123000234 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272123000235 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272123000236 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 272123000237 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272123000238 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272123000239 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 272123000240 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 272123000241 Subunit I/III interface [polypeptide binding]; other site 272123000242 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123000243 putative active site [active] 272123000244 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272123000245 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 272123000246 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 272123000247 putative catalytic residues [active] 272123000248 NACHT domain; Region: NACHT; pfam05729 272123000249 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 272123000250 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123000251 active site 272123000252 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272123000253 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272123000254 dimer interface [polypeptide binding]; other site 272123000255 ssDNA binding site [nucleotide binding]; other site 272123000256 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272123000257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272123000258 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272123000259 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272123000260 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272123000261 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272123000262 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272123000263 NAD-dependent deacetylase; Provisional; Region: PRK00481 272123000264 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272123000265 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272123000266 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272123000267 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 272123000268 Ligand Binding Site [chemical binding]; other site 272123000269 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 272123000270 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 272123000271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123000272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123000273 Coenzyme A binding pocket [chemical binding]; other site 272123000274 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 272123000275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272123000276 N-terminal plug; other site 272123000277 ligand-binding site [chemical binding]; other site 272123000278 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272123000279 Fasciclin domain; Region: Fasciclin; pfam02469 272123000280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 272123000281 HEAT repeats; Region: HEAT_2; pfam13646 272123000282 HEAT repeats; Region: HEAT_2; pfam13646 272123000283 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272123000284 HEAT repeats; Region: HEAT_2; pfam13646 272123000285 CpeS-like protein; Region: CpeS; pfam09367 272123000286 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272123000287 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 272123000288 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 272123000289 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272123000290 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272123000291 metal-binding site [ion binding] 272123000292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123000293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123000294 motif II; other site 272123000295 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123000296 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123000297 phosphopeptide binding site; other site 272123000298 TPR repeat; Region: TPR_11; pfam13414 272123000299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000300 binding surface 272123000301 TPR motif; other site 272123000302 TPR repeat; Region: TPR_11; pfam13414 272123000303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000304 TPR motif; other site 272123000305 TPR repeat; Region: TPR_11; pfam13414 272123000306 binding surface 272123000307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000308 binding surface 272123000309 TPR repeat; Region: TPR_11; pfam13414 272123000310 TPR motif; other site 272123000311 TPR repeat; Region: TPR_11; pfam13414 272123000312 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272123000313 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272123000314 HflX GTPase family; Region: HflX; cd01878 272123000315 G1 box; other site 272123000316 GTP/Mg2+ binding site [chemical binding]; other site 272123000317 Switch I region; other site 272123000318 G2 box; other site 272123000319 G3 box; other site 272123000320 Switch II region; other site 272123000321 G4 box; other site 272123000322 G5 box; other site 272123000323 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272123000324 GSH binding site [chemical binding]; other site 272123000325 catalytic residues [active] 272123000326 glutathione synthetase; Provisional; Region: PRK05246 272123000327 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272123000328 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272123000329 cell division protein FtsZ; Validated; Region: PRK09330 272123000330 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272123000331 nucleotide binding site [chemical binding]; other site 272123000332 SulA interaction site; other site 272123000333 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272123000334 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272123000335 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 272123000336 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 272123000337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123000338 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123000339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123000340 DNA binding residues [nucleotide binding] 272123000341 Uncharacterized conserved protein [Function unknown]; Region: COG4095 272123000342 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272123000343 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272123000344 B12 binding site [chemical binding]; other site 272123000345 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 272123000346 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 272123000347 putative hydrophobic ligand binding site [chemical binding]; other site 272123000348 Abortive infection C-terminus; Region: Abi_C; pfam14355 272123000349 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123000350 putative active site [active] 272123000351 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 272123000352 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272123000353 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 272123000354 active site 272123000355 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272123000356 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 272123000357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123000358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123000359 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123000360 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123000361 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123000362 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123000363 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123000364 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123000365 Phosphotransferase enzyme family; Region: APH; pfam01636 272123000366 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272123000367 substrate binding site [chemical binding]; other site 272123000368 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272123000369 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272123000370 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272123000371 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272123000372 E3 interaction surface; other site 272123000373 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123000374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123000375 ligand binding site [chemical binding]; other site 272123000376 flexible hinge region; other site 272123000377 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123000378 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272123000379 putative active site [active] 272123000380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123000381 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272123000382 Walker A/P-loop; other site 272123000383 ATP binding site [chemical binding]; other site 272123000384 Q-loop/lid; other site 272123000385 ABC transporter signature motif; other site 272123000386 Walker B; other site 272123000387 D-loop; other site 272123000388 H-loop/switch region; other site 272123000389 Homeodomain-like domain; Region: HTH_23; pfam13384 272123000390 Winged helix-turn helix; Region: HTH_29; pfam13551 272123000391 Winged helix-turn helix; Region: HTH_33; pfam13592 272123000392 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 272123000393 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 272123000394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123000395 NAD(P) binding site [chemical binding]; other site 272123000396 active site 272123000397 TIGR02646 family protein; Region: TIGR02646 272123000398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123000399 AAA domain; Region: AAA_21; pfam13304 272123000400 Walker A/P-loop; other site 272123000401 ATP binding site [chemical binding]; other site 272123000402 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 272123000403 glutaminase A; Region: Gln_ase; TIGR03814 272123000404 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272123000405 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272123000406 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 272123000407 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272123000408 active site 272123000409 ATP-binding site [chemical binding]; other site 272123000410 pantoate-binding site; other site 272123000411 HXXH motif; other site 272123000412 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272123000413 CMP-binding site; other site 272123000414 The sites determining sugar specificity; other site 272123000415 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272123000416 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272123000417 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272123000418 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272123000419 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 272123000420 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 272123000421 putative NADP binding site [chemical binding]; other site 272123000422 putative substrate binding site [chemical binding]; other site 272123000423 active site 272123000424 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 272123000425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123000426 FeS/SAM binding site; other site 272123000427 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 272123000428 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 272123000429 CHAT domain; Region: CHAT; cl17868 272123000430 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123000431 CHASE2 domain; Region: CHASE2; pfam05226 272123000432 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123000433 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123000434 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123000435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000436 binding surface 272123000437 TPR motif; other site 272123000438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000439 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123000441 binding surface 272123000442 TPR motif; other site 272123000443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123000444 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 272123000445 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123000446 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123000447 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123000448 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 272123000449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123000450 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123000451 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123000452 CHASE2 domain; Region: CHASE2; pfam05226 272123000453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123000454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000455 dimer interface [polypeptide binding]; other site 272123000456 phosphorylation site [posttranslational modification] 272123000457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000458 ATP binding site [chemical binding]; other site 272123000459 Mg2+ binding site [ion binding]; other site 272123000460 G-X-G motif; other site 272123000461 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000463 active site 272123000464 phosphorylation site [posttranslational modification] 272123000465 intermolecular recognition site; other site 272123000466 dimerization interface [polypeptide binding]; other site 272123000467 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000469 active site 272123000470 phosphorylation site [posttranslational modification] 272123000471 intermolecular recognition site; other site 272123000472 dimerization interface [polypeptide binding]; other site 272123000473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123000474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000475 dimer interface [polypeptide binding]; other site 272123000476 phosphorylation site [posttranslational modification] 272123000477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000478 ATP binding site [chemical binding]; other site 272123000479 Mg2+ binding site [ion binding]; other site 272123000480 G-X-G motif; other site 272123000481 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 272123000482 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272123000483 active site 272123000484 intersubunit interface [polypeptide binding]; other site 272123000485 catalytic residue [active] 272123000486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272123000487 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272123000488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272123000489 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272123000490 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000491 GAF domain; Region: GAF; pfam01590 272123000492 CHASE3 domain; Region: CHASE3; pfam05227 272123000493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000494 PAS domain; Region: PAS_9; pfam13426 272123000495 putative active site [active] 272123000496 heme pocket [chemical binding]; other site 272123000497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000498 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123000499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000500 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000502 dimer interface [polypeptide binding]; other site 272123000503 phosphorylation site [posttranslational modification] 272123000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000505 ATP binding site [chemical binding]; other site 272123000506 Mg2+ binding site [ion binding]; other site 272123000507 G-X-G motif; other site 272123000508 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000510 active site 272123000511 phosphorylation site [posttranslational modification] 272123000512 intermolecular recognition site; other site 272123000513 dimerization interface [polypeptide binding]; other site 272123000514 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000516 active site 272123000517 phosphorylation site [posttranslational modification] 272123000518 intermolecular recognition site; other site 272123000519 dimerization interface [polypeptide binding]; other site 272123000520 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123000521 putative binding surface; other site 272123000522 active site 272123000523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123000524 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272123000525 Walker A motif; other site 272123000526 ATP binding site [chemical binding]; other site 272123000527 Walker B motif; other site 272123000528 arginine finger; other site 272123000529 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 272123000530 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 272123000531 phage tail protein domain; Region: tail_TIGR02242 272123000532 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 272123000533 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 272123000534 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 272123000535 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 272123000536 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 272123000537 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 272123000538 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 272123000539 Phage protein D [General function prediction only]; Region: COG3500 272123000540 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 272123000541 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272123000542 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 272123000543 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 272123000544 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 272123000545 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 272123000546 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 272123000547 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 272123000548 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 272123000549 nucleotide binding site [chemical binding]; other site 272123000550 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272123000551 SBD interface [polypeptide binding]; other site 272123000552 UV-endonuclease UvdE; Region: UvdE; cl10036 272123000553 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 272123000554 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272123000555 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 272123000556 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272123000557 trimer interface [polypeptide binding]; other site 272123000558 active site 272123000559 substrate binding site [chemical binding]; other site 272123000560 CoA binding site [chemical binding]; other site 272123000561 SKI/SNO/DAC family; Region: Ski_Sno; pfam02437 272123000562 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 272123000563 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 272123000564 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 272123000565 active site 272123000566 catalytic residues [active] 272123000567 metal binding site [ion binding]; metal-binding site 272123000568 NifZ domain; Region: NifZ; pfam04319 272123000569 NifT/FixU protein; Region: NifT; pfam06988 272123000570 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272123000571 dimer interface [polypeptide binding]; other site 272123000572 [2Fe-2S] cluster binding site [ion binding]; other site 272123000573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123000574 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123000575 catalytic residues [active] 272123000576 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272123000577 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272123000578 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 272123000579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000581 binding surface 272123000582 TPR motif; other site 272123000583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000585 binding surface 272123000586 TPR motif; other site 272123000587 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000591 binding surface 272123000592 TPR motif; other site 272123000593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000595 binding surface 272123000596 TPR motif; other site 272123000597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000600 binding surface 272123000601 TPR motif; other site 272123000602 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000605 binding surface 272123000606 TPR motif; other site 272123000607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123000608 CHAT domain; Region: CHAT; pfam12770 272123000609 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272123000610 Uncharacterized conserved protein [Function unknown]; Region: COG1633 272123000611 dimanganese center [ion binding]; other site 272123000612 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 272123000613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123000614 FeS/SAM binding site; other site 272123000615 HemN C-terminal domain; Region: HemN_C; pfam06969 272123000616 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 272123000617 heme binding pocket [chemical binding]; other site 272123000618 heme ligand [chemical binding]; other site 272123000619 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123000620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000621 active site 272123000622 phosphorylation site [posttranslational modification] 272123000623 intermolecular recognition site; other site 272123000624 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123000625 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123000626 PAS domain; Region: PAS_9; pfam13426 272123000627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000628 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123000629 putative active site [active] 272123000630 heme pocket [chemical binding]; other site 272123000631 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123000632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000633 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123000634 putative active site [active] 272123000635 heme pocket [chemical binding]; other site 272123000636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000637 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123000638 putative active site [active] 272123000639 heme pocket [chemical binding]; other site 272123000640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000641 putative active site [active] 272123000642 heme pocket [chemical binding]; other site 272123000643 hypothetical protein; Provisional; Region: PRK13560 272123000644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000645 putative active site [active] 272123000646 heme pocket [chemical binding]; other site 272123000647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000648 putative active site [active] 272123000649 heme pocket [chemical binding]; other site 272123000650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123000651 putative active site [active] 272123000652 heme pocket [chemical binding]; other site 272123000653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000654 dimer interface [polypeptide binding]; other site 272123000655 phosphorylation site [posttranslational modification] 272123000656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000657 ATP binding site [chemical binding]; other site 272123000658 Mg2+ binding site [ion binding]; other site 272123000659 G-X-G motif; other site 272123000660 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123000661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000662 active site 272123000663 phosphorylation site [posttranslational modification] 272123000664 intermolecular recognition site; other site 272123000665 dimerization interface [polypeptide binding]; other site 272123000666 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000668 active site 272123000669 phosphorylation site [posttranslational modification] 272123000670 intermolecular recognition site; other site 272123000671 dimerization interface [polypeptide binding]; other site 272123000672 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000674 active site 272123000675 phosphorylation site [posttranslational modification] 272123000676 intermolecular recognition site; other site 272123000677 dimerization interface [polypeptide binding]; other site 272123000678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123000679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123000680 phosphorylation site [posttranslational modification] 272123000681 dimer interface [polypeptide binding]; other site 272123000682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123000683 ATP binding site [chemical binding]; other site 272123000684 Mg2+ binding site [ion binding]; other site 272123000685 G-X-G motif; other site 272123000686 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000688 active site 272123000689 phosphorylation site [posttranslational modification] 272123000690 intermolecular recognition site; other site 272123000691 dimerization interface [polypeptide binding]; other site 272123000692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123000693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123000694 metal binding site [ion binding]; metal-binding site 272123000695 active site 272123000696 I-site; other site 272123000697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123000698 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 272123000699 diiron binding motif [ion binding]; other site 272123000700 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272123000701 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272123000702 Walker A/P-loop; other site 272123000703 ATP binding site [chemical binding]; other site 272123000704 Q-loop/lid; other site 272123000705 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272123000706 ABC transporter signature motif; other site 272123000707 Walker B; other site 272123000708 D-loop; other site 272123000709 H-loop/switch region; other site 272123000710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 272123000711 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 272123000712 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272123000713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272123000714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123000715 catalytic residue [active] 272123000716 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 272123000717 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272123000718 nucleotide binding site/active site [active] 272123000719 HIT family signature motif; other site 272123000720 catalytic residue [active] 272123000721 ATP adenylyltransferase; Region: ATP_transf; pfam09830 272123000722 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272123000723 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272123000724 dimer interface [polypeptide binding]; other site 272123000725 motif 1; other site 272123000726 active site 272123000727 motif 2; other site 272123000728 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272123000729 putative deacylase active site [active] 272123000730 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272123000731 active site 272123000732 motif 3; other site 272123000733 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272123000734 anticodon binding site; other site 272123000735 Methyltransferase domain; Region: Methyltransf_12; pfam08242 272123000736 DNA binding domain, excisionase family; Region: excise; TIGR01764 272123000737 PIN domain; Region: PIN_3; pfam13470 272123000738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272123000739 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 272123000740 putative NAD(P) binding site [chemical binding]; other site 272123000741 catalytic Zn binding site [ion binding]; other site 272123000742 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272123000743 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272123000744 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 272123000745 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272123000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123000747 putative substrate translocation pore; other site 272123000748 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 272123000749 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 272123000750 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272123000751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123000752 RNA binding surface [nucleotide binding]; other site 272123000753 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 272123000754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123000755 FeS/SAM binding site; other site 272123000756 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272123000757 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272123000758 SmpB-tmRNA interface; other site 272123000759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123000760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000761 active site 272123000762 phosphorylation site [posttranslational modification] 272123000763 intermolecular recognition site; other site 272123000764 dimerization interface [polypeptide binding]; other site 272123000765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123000766 DNA binding residues [nucleotide binding] 272123000767 dimerization interface [polypeptide binding]; other site 272123000768 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272123000769 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272123000770 active site 272123000771 hypothetical protein; Validated; Region: PRK00153 272123000772 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272123000773 FAD binding domain; Region: FAD_binding_4; pfam01565 272123000774 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272123000775 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272123000776 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272123000777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123000778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123000779 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272123000780 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272123000781 active site 272123000782 (T/H)XGH motif; other site 272123000783 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 272123000784 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272123000785 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272123000786 thiamine monophosphate kinase; Provisional; Region: PRK05731 272123000787 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272123000788 ATP binding site [chemical binding]; other site 272123000789 dimerization interface [polypeptide binding]; other site 272123000790 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123000791 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 272123000792 active site 272123000793 elongation factor P; Validated; Region: PRK00529 272123000794 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272123000795 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272123000796 RNA binding site [nucleotide binding]; other site 272123000797 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272123000798 RNA binding site [nucleotide binding]; other site 272123000799 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272123000800 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272123000801 carboxyltransferase (CT) interaction site; other site 272123000802 biotinylation site [posttranslational modification]; other site 272123000803 Sporulation and spore germination; Region: Germane; pfam10646 272123000804 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 272123000805 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 272123000806 active site 272123000807 Zn binding site [ion binding]; other site 272123000808 O-Antigen ligase; Region: Wzy_C; cl04850 272123000809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123000810 active site 272123000811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123000812 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123000813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123000814 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272123000815 active site 272123000816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123000817 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123000818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123000819 Walker A/P-loop; other site 272123000820 ATP binding site [chemical binding]; other site 272123000821 Q-loop/lid; other site 272123000822 ABC transporter signature motif; other site 272123000823 Walker B; other site 272123000824 D-loop; other site 272123000825 H-loop/switch region; other site 272123000826 Bacterial sugar transferase; Region: Bac_transf; cl00939 272123000827 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272123000828 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272123000829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123000830 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 272123000831 putative ADP-binding pocket [chemical binding]; other site 272123000832 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 272123000833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123000834 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 272123000835 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272123000836 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272123000837 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123000838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123000839 active site 272123000840 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272123000841 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123000842 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272123000843 active site 272123000844 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123000845 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123000846 active site 272123000847 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272123000848 extended (e) SDRs; Region: SDR_e; cd08946 272123000849 NAD(P) binding site [chemical binding]; other site 272123000850 active site 272123000851 substrate binding site [chemical binding]; other site 272123000852 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272123000853 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272123000854 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272123000855 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 272123000856 substrate binding site; other site 272123000857 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 272123000858 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123000859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000860 binding surface 272123000861 TPR repeat; Region: TPR_11; pfam13414 272123000862 TPR motif; other site 272123000863 TPR repeat; Region: TPR_11; pfam13414 272123000864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000865 binding surface 272123000866 TPR motif; other site 272123000867 TPR repeat; Region: TPR_11; pfam13414 272123000868 TPR repeat; Region: TPR_11; pfam13414 272123000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123000870 binding surface 272123000871 TPR motif; other site 272123000872 Protein phosphatase 2C; Region: PP2C_2; pfam13672 272123000873 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 272123000874 metal ion-dependent adhesion site (MIDAS); other site 272123000875 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 272123000876 Response regulator receiver domain; Region: Response_reg; pfam00072 272123000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000878 active site 272123000879 phosphorylation site [posttranslational modification] 272123000880 intermolecular recognition site; other site 272123000881 dimerization interface [polypeptide binding]; other site 272123000882 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272123000883 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272123000884 Walker A/P-loop; other site 272123000885 ATP binding site [chemical binding]; other site 272123000886 Q-loop/lid; other site 272123000887 ABC transporter signature motif; other site 272123000888 Walker B; other site 272123000889 D-loop; other site 272123000890 H-loop/switch region; other site 272123000891 TOBE domain; Region: TOBE_2; pfam08402 272123000892 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272123000893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123000894 RNA binding surface [nucleotide binding]; other site 272123000895 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272123000896 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123000897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123000898 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123000899 WD40 repeats; Region: WD40; smart00320 272123000900 WD40 repeats; Region: WD40; smart00320 272123000901 WD domain, G-beta repeat; Region: WD40; pfam00400 272123000902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123000903 structural tetrad; other site 272123000904 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123000905 structural tetrad; other site 272123000906 allophycocyanin, beta subunit; Region: apcB; TIGR01337 272123000907 glutamine synthetase, type I; Region: GlnA; TIGR00653 272123000908 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272123000909 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272123000910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123000911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123000912 S-adenosylmethionine binding site [chemical binding]; other site 272123000913 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 272123000914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123000915 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 272123000916 putative ADP-binding pocket [chemical binding]; other site 272123000917 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 272123000918 Uncharacterized conserved protein [Function unknown]; Region: COG3391 272123000919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123000920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123000921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123000922 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123000923 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 272123000924 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 272123000925 G1 box; other site 272123000926 GTP/Mg2+ binding site [chemical binding]; other site 272123000927 Switch I region; other site 272123000928 G2 box; other site 272123000929 Switch II region; other site 272123000930 G3 box; other site 272123000931 G4 box; other site 272123000932 G5 box; other site 272123000933 Domain of unknown function (DUF697); Region: DUF697; pfam05128 272123000934 CP12 domain; Region: CP12; pfam02672 272123000935 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123000936 oligomeric interface; other site 272123000937 putative active site [active] 272123000938 homodimer interface [polypeptide binding]; other site 272123000939 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 272123000940 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272123000941 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 272123000942 active site 272123000943 Substrate binding site; other site 272123000944 Mg++ binding site; other site 272123000945 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272123000946 putative trimer interface [polypeptide binding]; other site 272123000947 putative CoA binding site [chemical binding]; other site 272123000948 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272123000949 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 272123000950 YciI-like protein; Reviewed; Region: PRK12864 272123000951 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272123000952 Transglycosylase; Region: Transgly; pfam00912 272123000953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272123000954 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 272123000955 putative catalytic site [active] 272123000956 putative metal binding site [ion binding]; other site 272123000957 putative phosphate binding site [ion binding]; other site 272123000958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123000959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123000960 active site 272123000961 phosphorylation site [posttranslational modification] 272123000962 intermolecular recognition site; other site 272123000963 dimerization interface [polypeptide binding]; other site 272123000964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123000965 DNA binding site [nucleotide binding] 272123000966 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272123000967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272123000968 active site residue [active] 272123000969 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272123000970 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272123000971 catalytic site [active] 272123000972 putative active site [active] 272123000973 putative substrate binding site [chemical binding]; other site 272123000974 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272123000975 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272123000976 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272123000977 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272123000978 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272123000979 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272123000980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123000981 catalytic residue [active] 272123000982 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 272123000983 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272123000984 Bacterial Ig-like domain; Region: Big_5; pfam13205 272123000985 TIGR03943 family protein; Region: TIGR03943 272123000986 Predicted permeases [General function prediction only]; Region: COG0701 272123000987 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 272123000988 active site 272123000989 catalytic site [active] 272123000990 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 272123000991 Protein of unknown function, DUF488; Region: DUF488; pfam04343 272123000992 Protein of unknown function, DUF488; Region: DUF488; pfam04343 272123000993 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272123000994 classical (c) SDRs; Region: SDR_c; cd05233 272123000995 NAD(P) binding site [chemical binding]; other site 272123000996 active site 272123000997 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272123000998 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272123000999 putative tRNA-binding site [nucleotide binding]; other site 272123001000 B3/4 domain; Region: B3_4; pfam03483 272123001001 tRNA synthetase B5 domain; Region: B5; smart00874 272123001002 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272123001003 dimer interface [polypeptide binding]; other site 272123001004 motif 1; other site 272123001005 motif 3; other site 272123001006 motif 2; other site 272123001007 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272123001008 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272123001009 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272123001010 putative trimer interface [polypeptide binding]; other site 272123001011 putative CoA binding site [chemical binding]; other site 272123001012 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272123001013 trimer interface [polypeptide binding]; other site 272123001014 active site 272123001015 substrate binding site [chemical binding]; other site 272123001016 CoA binding site [chemical binding]; other site 272123001017 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272123001018 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272123001019 hydrophobic ligand binding site; other site 272123001020 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 272123001021 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272123001022 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 272123001023 Ycf39; Provisional; Region: ycf39; CHL00194 272123001024 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272123001025 NAD(P) binding site [chemical binding]; other site 272123001026 putative active site [active] 272123001027 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 272123001028 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272123001029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001031 active site 272123001032 phosphorylation site [posttranslational modification] 272123001033 intermolecular recognition site; other site 272123001034 dimerization interface [polypeptide binding]; other site 272123001035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123001036 DNA binding site [nucleotide binding] 272123001037 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 272123001038 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272123001039 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 272123001040 active site 272123001041 Predicted esterase [General function prediction only]; Region: COG0400 272123001042 putative hydrolase; Provisional; Region: PRK11460 272123001043 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 272123001044 Protein of unknown function DUF262; Region: DUF262; pfam03235 272123001045 Uncharacterized conserved protein [Function unknown]; Region: COG4938 272123001046 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 272123001047 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272123001048 Flavoprotein; Region: Flavoprotein; pfam02441 272123001049 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272123001050 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 272123001051 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123001052 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123001053 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123001054 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123001055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123001056 catalytic loop [active] 272123001057 iron binding site [ion binding]; other site 272123001058 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272123001059 Catalytic site; other site 272123001060 Staphylococcal nuclease homologue; Region: SNase; pfam00565 272123001061 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272123001062 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272123001063 active site 272123001064 dimerization interface [polypeptide binding]; other site 272123001065 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 272123001066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123001067 HSP70 interaction site [polypeptide binding]; other site 272123001068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001069 TPR repeat; Region: TPR_11; pfam13414 272123001070 binding surface 272123001071 TPR motif; other site 272123001072 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 272123001073 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272123001074 dimer interface [polypeptide binding]; other site 272123001075 motif 1; other site 272123001076 active site 272123001077 motif 2; other site 272123001078 Domain of Unknown Function (DUF1081); Region: DUF1081; pfam06448 272123001079 motif 3; other site 272123001080 Ferredoxin [Energy production and conversion]; Region: COG1146 272123001081 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272123001082 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272123001083 Walker A/P-loop; other site 272123001084 ATP binding site [chemical binding]; other site 272123001085 Q-loop/lid; other site 272123001086 ABC transporter signature motif; other site 272123001087 Walker B; other site 272123001088 D-loop; other site 272123001089 H-loop/switch region; other site 272123001090 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 272123001091 YcaO-like family; Region: YcaO; pfam02624 272123001092 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 272123001093 Amidohydrolase; Region: Amidohydro_2; pfam04909 272123001094 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123001095 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123001096 active site 272123001097 ATP binding site [chemical binding]; other site 272123001098 substrate binding site [chemical binding]; other site 272123001099 activation loop (A-loop); other site 272123001100 AAA ATPase domain; Region: AAA_16; pfam13191 272123001101 Predicted ATPase [General function prediction only]; Region: COG3899 272123001102 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123001103 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123001104 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272123001105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123001106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123001107 DNA binding residues [nucleotide binding] 272123001108 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 272123001109 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272123001110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123001111 Probable transposase; Region: OrfB_IS605; pfam01385 272123001112 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 272123001113 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272123001114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123001115 putative binding surface; other site 272123001116 active site 272123001117 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272123001118 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272123001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123001120 ATP binding site [chemical binding]; other site 272123001121 Mg2+ binding site [ion binding]; other site 272123001122 G-X-G motif; other site 272123001123 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272123001124 Response regulator receiver domain; Region: Response_reg; pfam00072 272123001125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001126 active site 272123001127 phosphorylation site [posttranslational modification] 272123001128 intermolecular recognition site; other site 272123001129 dimerization interface [polypeptide binding]; other site 272123001130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001131 binding surface 272123001132 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123001133 TPR motif; other site 272123001134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123001135 dimerization interface [polypeptide binding]; other site 272123001136 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272123001137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272123001138 dimer interface [polypeptide binding]; other site 272123001139 putative CheW interface [polypeptide binding]; other site 272123001140 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272123001141 Response regulator receiver domain; Region: Response_reg; pfam00072 272123001142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001143 active site 272123001144 phosphorylation site [posttranslational modification] 272123001145 intermolecular recognition site; other site 272123001146 dimerization interface [polypeptide binding]; other site 272123001147 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 272123001148 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123001149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001150 active site 272123001151 phosphorylation site [posttranslational modification] 272123001152 intermolecular recognition site; other site 272123001153 dimerization interface [polypeptide binding]; other site 272123001154 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272123001155 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272123001156 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272123001157 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272123001158 Ligand Binding Site [chemical binding]; other site 272123001159 cytochrome c biogenesis protein; Region: ccsA; CHL00045 272123001160 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 272123001161 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123001162 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272123001163 structural tetrad; other site 272123001164 Protein of unknown function (DUF98); Region: DUF98; pfam01947 272123001165 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272123001166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272123001167 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272123001168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272123001169 Predicted integral membrane protein [Function unknown]; Region: COG0762 272123001170 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 272123001171 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 272123001172 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 272123001173 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272123001174 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 272123001175 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 272123001176 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 272123001177 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272123001178 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 272123001179 CAAX protease self-immunity; Region: Abi; pfam02517 272123001180 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 272123001181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123001182 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123001183 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272123001184 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272123001185 hinge region; other site 272123001186 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272123001187 putative nucleotide binding site [chemical binding]; other site 272123001188 uridine monophosphate binding site [chemical binding]; other site 272123001189 homohexameric interface [polypeptide binding]; other site 272123001190 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 272123001191 putative catalytic residue [active] 272123001192 hydrolase, alpha/beta fold family protein; Region: PLN02824 272123001193 Serine hydrolase; Region: Ser_hydrolase; cl17834 272123001194 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123001195 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272123001196 putative active site [active] 272123001197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123001198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123001199 Walker A/P-loop; other site 272123001200 ATP binding site [chemical binding]; other site 272123001201 Q-loop/lid; other site 272123001202 ABC transporter signature motif; other site 272123001203 Walker B; other site 272123001204 D-loop; other site 272123001205 H-loop/switch region; other site 272123001206 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272123001207 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123001208 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 272123001209 Haemolytic domain; Region: Haemolytic; pfam01809 272123001210 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272123001211 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 272123001212 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272123001213 ABC1 family; Region: ABC1; cl17513 272123001214 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272123001215 active site 272123001216 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 272123001217 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272123001218 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272123001219 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272123001220 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272123001221 Ligand Binding Site [chemical binding]; other site 272123001222 K+-transporting ATPase, c chain; Region: KdpC; cl00944 272123001223 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272123001224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123001225 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272123001226 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272123001227 FAD binding domain; Region: FAD_binding_3; pfam01494 272123001228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123001229 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272123001230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123001231 primosomal protein N' Region: priA; TIGR00595 272123001232 ATP binding site [chemical binding]; other site 272123001233 putative Mg++ binding site [ion binding]; other site 272123001234 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272123001235 ATP-binding site [chemical binding]; other site 272123001236 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123001237 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 272123001238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123001239 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123001240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123001241 DNA binding residues [nucleotide binding] 272123001242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123001243 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123001244 Coenzyme A binding pocket [chemical binding]; other site 272123001245 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 272123001246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123001247 Uncharacterized conserved protein [Function unknown]; Region: COG3349 272123001248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123001249 Uncharacterized conserved protein [Function unknown]; Region: COG3349 272123001250 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 272123001251 substrate binding pocket [chemical binding]; other site 272123001252 substrate-Mg2+ binding site; other site 272123001253 aspartate-rich region 1; other site 272123001254 aspartate-rich region 2; other site 272123001255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123001256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123001257 active site 272123001258 ATP binding site [chemical binding]; other site 272123001259 substrate binding site [chemical binding]; other site 272123001260 activation loop (A-loop); other site 272123001261 AAA ATPase domain; Region: AAA_16; pfam13191 272123001262 Predicted ATPase [General function prediction only]; Region: COG3899 272123001263 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123001264 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123001265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123001266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123001267 dimer interface [polypeptide binding]; other site 272123001268 phosphorylation site [posttranslational modification] 272123001269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123001270 ATP binding site [chemical binding]; other site 272123001271 G-X-G motif; other site 272123001272 cytochrome c6; Provisional; Region: PRK13697 272123001273 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272123001274 Cytochrome c; Region: Cytochrom_C; cl11414 272123001275 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272123001276 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 272123001277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001278 binding surface 272123001279 TPR motif; other site 272123001280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001281 binding surface 272123001282 TPR motif; other site 272123001283 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123001284 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272123001285 C-terminal domain interface [polypeptide binding]; other site 272123001286 GSH binding site (G-site) [chemical binding]; other site 272123001287 dimer interface [polypeptide binding]; other site 272123001288 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 272123001289 putative N-terminal domain interface [polypeptide binding]; other site 272123001290 HAS barrel domain; Region: HAS-barrel; pfam09378 272123001291 HerA helicase [Replication, recombination, and repair]; Region: COG0433 272123001292 Domain of unknown function DUF87; Region: DUF87; pfam01935 272123001293 RNA polymerase sigma factor; Validated; Region: PRK05949 272123001294 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123001295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123001296 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123001297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123001298 DNA binding residues [nucleotide binding] 272123001299 CHAT domain; Region: CHAT; cl17868 272123001300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123001301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001302 TPR motif; other site 272123001303 binding surface 272123001304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123001305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123001306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001307 binding surface 272123001308 TPR motif; other site 272123001309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123001310 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272123001311 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123001312 putative active site [active] 272123001313 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272123001314 putative active site [active] 272123001315 homotetrameric interface [polypeptide binding]; other site 272123001316 metal binding site [ion binding]; metal-binding site 272123001317 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 272123001318 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272123001319 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 272123001320 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272123001321 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272123001322 homodimer interface [polypeptide binding]; other site 272123001323 Walker A motif; other site 272123001324 ATP binding site [chemical binding]; other site 272123001325 hydroxycobalamin binding site [chemical binding]; other site 272123001326 Walker B motif; other site 272123001327 excinuclease ABC subunit B; Provisional; Region: PRK05298 272123001328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123001329 ATP binding site [chemical binding]; other site 272123001330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123001331 nucleotide binding region [chemical binding]; other site 272123001332 ATP-binding site [chemical binding]; other site 272123001333 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272123001334 UvrB/uvrC motif; Region: UVR; pfam02151 272123001335 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272123001336 active site 272123001337 NTP binding site [chemical binding]; other site 272123001338 metal binding triad [ion binding]; metal-binding site 272123001339 antibiotic binding site [chemical binding]; other site 272123001340 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 272123001341 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272123001342 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272123001343 inhibitor-cofactor binding pocket; inhibition site 272123001344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123001345 catalytic residue [active] 272123001346 Protein of unknown function (DUF561); Region: DUF561; pfam04481 272123001347 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 272123001348 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272123001349 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272123001350 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272123001351 G1 box; other site 272123001352 GTP/Mg2+ binding site [chemical binding]; other site 272123001353 Switch I region; other site 272123001354 G2 box; other site 272123001355 Switch II region; other site 272123001356 G3 box; other site 272123001357 G4 box; other site 272123001358 G5 box; other site 272123001359 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272123001360 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123001361 putative active site [active] 272123001362 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272123001363 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272123001364 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123001365 putative active site [active] 272123001366 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123001367 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272123001368 Protein of unknown function DUF262; Region: DUF262; pfam03235 272123001369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123001370 AAA domain; Region: AAA_21; pfam13304 272123001371 Walker A/P-loop; other site 272123001372 ATP binding site [chemical binding]; other site 272123001373 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 272123001374 conserved hypothetical protein; Region: TIGR02231 272123001375 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 272123001376 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 272123001377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272123001378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272123001379 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 272123001380 putative dimerization interface [polypeptide binding]; other site 272123001381 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123001382 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123001383 Hexamer interface [polypeptide binding]; other site 272123001384 Hexagonal pore residue; other site 272123001385 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123001386 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123001387 Hexamer interface [polypeptide binding]; other site 272123001388 Hexagonal pore residue; other site 272123001389 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272123001390 putative trimer interface [polypeptide binding]; other site 272123001391 putative CoA binding site [chemical binding]; other site 272123001392 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272123001393 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 272123001394 trimer interface [polypeptide binding]; other site 272123001395 active site 272123001396 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 272123001397 putative multimerization interface [polypeptide binding]; other site 272123001398 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 272123001399 putative multimerization interface [polypeptide binding]; other site 272123001400 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 272123001401 putative multimerization interface [polypeptide binding]; other site 272123001402 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 272123001403 Hexamer/Pentamer interface [polypeptide binding]; other site 272123001404 central pore; other site 272123001405 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123001406 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123001407 Hexamer interface [polypeptide binding]; other site 272123001408 Hexagonal pore residue; other site 272123001409 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123001410 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123001411 Hexamer interface [polypeptide binding]; other site 272123001412 Hexagonal pore residue; other site 272123001413 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 272123001414 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123001415 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 272123001416 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123001417 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 272123001418 Circadian oscillating protein COP23; Region: COP23; pfam14218 272123001419 Family description; Region: VCBS; pfam13517 272123001420 Family description; Region: VCBS; pfam13517 272123001421 Family description; Region: VCBS; pfam13517 272123001422 Family description; Region: VCBS; pfam13517 272123001423 Family description; Region: VCBS; pfam13517 272123001424 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272123001425 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272123001426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123001427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123001428 ligand binding site [chemical binding]; other site 272123001429 flexible hinge region; other site 272123001430 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123001431 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 272123001432 putative active site [active] 272123001433 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123001434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123001435 Walker A/P-loop; other site 272123001436 ATP binding site [chemical binding]; other site 272123001437 Q-loop/lid; other site 272123001438 ABC transporter signature motif; other site 272123001439 Walker B; other site 272123001440 D-loop; other site 272123001441 H-loop/switch region; other site 272123001442 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272123001443 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272123001444 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123001445 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123001446 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123001447 Uncharacterized conserved protein [Function unknown]; Region: COG4278 272123001448 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 272123001449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001450 binding surface 272123001451 TPR motif; other site 272123001452 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123001453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001454 binding surface 272123001455 TPR motif; other site 272123001456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001457 binding surface 272123001458 TPR motif; other site 272123001459 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123001460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001461 binding surface 272123001462 TPR motif; other site 272123001463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001464 binding surface 272123001465 TPR motif; other site 272123001466 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 272123001467 CHAT domain; Region: CHAT; cl17868 272123001468 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272123001469 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 272123001470 putative ligand binding site [chemical binding]; other site 272123001471 transaldolase-like protein; Provisional; Region: PTZ00411 272123001472 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 272123001473 active site 272123001474 dimer interface [polypeptide binding]; other site 272123001475 catalytic residue [active] 272123001476 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 272123001477 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272123001478 domain interfaces; other site 272123001479 active site 272123001480 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272123001481 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272123001482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272123001483 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 272123001484 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 272123001485 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123001486 catalytic core [active] 272123001487 citrate synthase; Provisional; Region: PRK14036 272123001488 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 272123001489 oxalacetate binding site [chemical binding]; other site 272123001490 citrylCoA binding site [chemical binding]; other site 272123001491 coenzyme A binding site [chemical binding]; other site 272123001492 catalytic triad [active] 272123001493 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 272123001494 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 272123001495 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 272123001496 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272123001497 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 272123001498 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 272123001499 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 272123001500 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 272123001501 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272123001502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 272123001503 Electron transfer DM13; Region: DM13; pfam10517 272123001504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123001505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272123001506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123001507 dimer interface [polypeptide binding]; other site 272123001508 phosphorylation site [posttranslational modification] 272123001509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123001510 ATP binding site [chemical binding]; other site 272123001511 Mg2+ binding site [ion binding]; other site 272123001512 G-X-G motif; other site 272123001513 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123001514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001515 active site 272123001516 phosphorylation site [posttranslational modification] 272123001517 intermolecular recognition site; other site 272123001518 dimerization interface [polypeptide binding]; other site 272123001519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123001520 DNA binding site [nucleotide binding] 272123001521 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123001522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123001523 S-adenosylmethionine binding site [chemical binding]; other site 272123001524 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 272123001525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123001526 FeS/SAM binding site; other site 272123001527 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 272123001528 alanine racemase; Reviewed; Region: alr; PRK00053 272123001529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272123001530 active site 272123001531 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272123001532 dimer interface [polypeptide binding]; other site 272123001533 substrate binding site [chemical binding]; other site 272123001534 catalytic residues [active] 272123001535 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272123001536 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272123001537 substrate binding site [chemical binding]; other site 272123001538 glutamase interaction surface [polypeptide binding]; other site 272123001539 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272123001540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123001541 Walker A motif; other site 272123001542 ATP binding site [chemical binding]; other site 272123001543 Walker B motif; other site 272123001544 arginine finger; other site 272123001545 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272123001546 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 272123001547 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 272123001548 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123001549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123001550 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272123001551 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272123001552 active site 272123001553 TDP-binding site; other site 272123001554 acceptor substrate-binding pocket; other site 272123001555 homodimer interface [polypeptide binding]; other site 272123001556 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272123001557 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272123001558 folate binding site [chemical binding]; other site 272123001559 NADP+ binding site [chemical binding]; other site 272123001560 TPR repeat; Region: TPR_11; pfam13414 272123001561 TPR repeat; Region: TPR_11; pfam13414 272123001562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001563 binding surface 272123001564 TPR motif; other site 272123001565 TPR repeat; Region: TPR_11; pfam13414 272123001566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001567 binding surface 272123001568 TPR motif; other site 272123001569 hypothetical protein; Provisional; Region: PRK02724 272123001570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272123001571 SPFH domain / Band 7 family; Region: Band_7; pfam01145 272123001572 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 272123001573 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272123001574 gamma subunit interface [polypeptide binding]; other site 272123001575 epsilon subunit interface [polypeptide binding]; other site 272123001576 LBP interface [polypeptide binding]; other site 272123001577 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 272123001578 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272123001579 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272123001580 alpha subunit interaction interface [polypeptide binding]; other site 272123001581 Walker A motif; other site 272123001582 ATP binding site [chemical binding]; other site 272123001583 Walker B motif; other site 272123001584 inhibitor binding site; inhibition site 272123001585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272123001586 valyl-tRNA synthetase; Region: valS; TIGR00422 272123001587 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272123001588 HIGH motif; other site 272123001589 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272123001590 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272123001591 active site 272123001592 KMSKS motif; other site 272123001593 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272123001594 tRNA binding surface [nucleotide binding]; other site 272123001595 anticodon binding site; other site 272123001596 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 272123001597 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272123001598 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 272123001599 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272123001600 dimer interface [polypeptide binding]; other site 272123001601 active site 272123001602 Schiff base residues; other site 272123001603 Tic20-like protein; Region: Tic20; pfam09685 272123001604 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123001605 oligomeric interface; other site 272123001606 putative active site [active] 272123001607 homodimer interface [polypeptide binding]; other site 272123001608 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272123001609 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272123001610 G1 box; other site 272123001611 putative GEF interaction site [polypeptide binding]; other site 272123001612 GTP/Mg2+ binding site [chemical binding]; other site 272123001613 Switch I region; other site 272123001614 G2 box; other site 272123001615 G3 box; other site 272123001616 Switch II region; other site 272123001617 G4 box; other site 272123001618 G5 box; other site 272123001619 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272123001620 Outer membrane lipoprotein; Region: YfiO; pfam13525 272123001621 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272123001622 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 272123001623 RNA recognition motif; Region: RRM; smart00360 272123001624 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272123001625 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 272123001626 putative ADP-binding pocket [chemical binding]; other site 272123001627 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 272123001628 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272123001629 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272123001630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123001631 S-adenosylmethionine binding site [chemical binding]; other site 272123001632 Tic22-like family; Region: Tic22; cl04468 272123001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123001634 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123001635 Coenzyme A binding pocket [chemical binding]; other site 272123001636 Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479 272123001637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123001638 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272123001639 catalytic site [active] 272123001640 UGMP family protein; Validated; Region: PRK09604 272123001641 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272123001642 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 272123001643 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 272123001644 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272123001645 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272123001646 catalytic site [active] 272123001647 G-X2-G-X-G-K; other site 272123001648 hypothetical protein; Provisional; Region: PRK04323 272123001649 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272123001650 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272123001651 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 272123001652 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272123001653 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272123001654 substrate binding pocket [chemical binding]; other site 272123001655 chain length determination region; other site 272123001656 substrate-Mg2+ binding site; other site 272123001657 catalytic residues [active] 272123001658 aspartate-rich region 1; other site 272123001659 active site lid residues [active] 272123001660 aspartate-rich region 2; other site 272123001661 glutamate racemase; Provisional; Region: PRK00865 272123001662 AMIN domain; Region: AMIN; pfam11741 272123001663 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123001664 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123001665 active site 272123001666 metal binding site [ion binding]; metal-binding site 272123001667 AMIN domain; Region: AMIN; pfam11741 272123001668 AMIN domain; Region: AMIN; pfam11741 272123001669 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123001670 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123001671 active site 272123001672 metal binding site [ion binding]; metal-binding site 272123001673 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272123001674 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272123001675 Uncharacterized conserved protein [Function unknown]; Region: COG2968 272123001676 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 272123001677 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272123001678 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272123001679 dimer interface [polypeptide binding]; other site 272123001680 ssDNA binding site [nucleotide binding]; other site 272123001681 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272123001682 rod shape-determining protein MreB; Provisional; Region: PRK13927 272123001683 MreB and similar proteins; Region: MreB_like; cd10225 272123001684 nucleotide binding site [chemical binding]; other site 272123001685 Mg binding site [ion binding]; other site 272123001686 putative protofilament interaction site [polypeptide binding]; other site 272123001687 RodZ interaction site [polypeptide binding]; other site 272123001688 rod shape-determining protein MreC; Provisional; Region: PRK13922 272123001689 rod shape-determining protein MreC; Region: MreC; pfam04085 272123001690 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 272123001691 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272123001692 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272123001693 catalytic motif [active] 272123001694 Zn binding site [ion binding]; other site 272123001695 RibD C-terminal domain; Region: RibD_C; cl17279 272123001696 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 272123001697 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123001698 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123001699 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123001700 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123001701 oligomeric interface; other site 272123001702 putative active site [active] 272123001703 homodimer interface [polypeptide binding]; other site 272123001704 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272123001705 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272123001706 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123001707 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 272123001708 putative active site [active] 272123001709 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 272123001710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123001711 ATP binding site [chemical binding]; other site 272123001712 putative Mg++ binding site [ion binding]; other site 272123001713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 272123001714 nucleotide binding region [chemical binding]; other site 272123001715 ATP-binding site [chemical binding]; other site 272123001716 Integrase core domain; Region: rve; pfam00665 272123001717 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 272123001718 AAA domain; Region: AAA_22; pfam13401 272123001719 AAA ATPase domain; Region: AAA_16; pfam13191 272123001720 CHAT domain; Region: CHAT; cl17868 272123001721 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 272123001722 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272123001723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123001724 ATP binding site [chemical binding]; other site 272123001725 putative Mg++ binding site [ion binding]; other site 272123001726 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 272123001727 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272123001728 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272123001729 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123001730 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 272123001731 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123001732 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123001733 Protein of unknown function DUF262; Region: DUF262; pfam03235 272123001734 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272123001735 Uncharacterized conserved protein [Function unknown]; Region: COG3472 272123001736 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272123001737 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272123001738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123001739 motif II; other site 272123001740 Nrap protein; Region: Nrap; pfam03813 272123001741 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 272123001742 hypothetical protein; Reviewed; Region: PRK09588 272123001743 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272123001744 EamA-like transporter family; Region: EamA; pfam00892 272123001745 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272123001746 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272123001747 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272123001748 precorrin-8X methylmutase; Validated; Region: PRK05953 272123001749 Precorrin-8X methylmutase; Region: CbiC; pfam02570 272123001750 Repair protein; Region: Repair_PSII; pfam04536 272123001751 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272123001752 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 272123001753 Response regulator receiver domain; Region: Response_reg; pfam00072 272123001754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001755 active site 272123001756 phosphorylation site [posttranslational modification] 272123001757 intermolecular recognition site; other site 272123001758 dimerization interface [polypeptide binding]; other site 272123001759 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123001760 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123001761 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123001762 anti sigma factor interaction site; other site 272123001763 regulatory phosphorylation site [posttranslational modification]; other site 272123001764 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 272123001765 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272123001766 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272123001767 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272123001768 dimerization interface [polypeptide binding]; other site 272123001769 DPS ferroxidase diiron center [ion binding]; other site 272123001770 ion pore; other site 272123001771 ParB-like nuclease domain; Region: ParBc; cl02129 272123001772 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272123001773 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 272123001774 Stage II sporulation protein; Region: SpoIID; pfam08486 272123001775 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123001776 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123001777 catalytic loop [active] 272123001778 iron binding site [ion binding]; other site 272123001779 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123001780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123001781 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272123001782 active site 272123001783 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 272123001784 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 272123001785 active site 272123001786 S2 subsite; other site 272123001787 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 272123001788 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123001789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123001790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123001791 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 272123001792 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 272123001793 putative NAD(P) binding site [chemical binding]; other site 272123001794 active site 272123001795 TPR repeat; Region: TPR_11; pfam13414 272123001796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001797 binding surface 272123001798 TPR motif; other site 272123001799 TPR repeat; Region: TPR_11; pfam13414 272123001800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123001801 binding surface 272123001802 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123001803 TPR motif; other site 272123001804 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272123001805 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 272123001806 GxxExxY protein; Region: GxxExxY; TIGR04256 272123001807 glycine dehydrogenase; Provisional; Region: PRK05367 272123001808 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272123001809 tetramer interface [polypeptide binding]; other site 272123001810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123001811 catalytic residue [active] 272123001812 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272123001813 tetramer interface [polypeptide binding]; other site 272123001814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123001815 catalytic residue [active] 272123001816 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272123001817 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272123001818 homodimer interface [polypeptide binding]; other site 272123001819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123001820 catalytic residue [active] 272123001821 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272123001822 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272123001823 active site 272123001824 ribulose/triose binding site [chemical binding]; other site 272123001825 phosphate binding site [ion binding]; other site 272123001826 substrate (anthranilate) binding pocket [chemical binding]; other site 272123001827 product (indole) binding pocket [chemical binding]; other site 272123001828 PAS domain; Region: PAS_9; pfam13426 272123001829 PAS domain S-box; Region: sensory_box; TIGR00229 272123001830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272123001831 putative active site [active] 272123001832 heme pocket [chemical binding]; other site 272123001833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123001834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123001835 dimer interface [polypeptide binding]; other site 272123001836 phosphorylation site [posttranslational modification] 272123001837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123001838 ATP binding site [chemical binding]; other site 272123001839 Mg2+ binding site [ion binding]; other site 272123001840 G-X-G motif; other site 272123001841 Response regulator receiver domain; Region: Response_reg; pfam00072 272123001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123001843 active site 272123001844 phosphorylation site [posttranslational modification] 272123001845 intermolecular recognition site; other site 272123001846 dimerization interface [polypeptide binding]; other site 272123001847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123001848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272123001849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123001850 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 272123001851 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 272123001852 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272123001853 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272123001854 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272123001855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123001856 S-adenosylmethionine binding site [chemical binding]; other site 272123001857 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123001858 putative active site [active] 272123001859 Uncharacterized conserved protein [Function unknown]; Region: COG1801 272123001860 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 272123001861 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 272123001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 272123001863 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272123001864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123001865 ATP binding site [chemical binding]; other site 272123001866 putative Mg++ binding site [ion binding]; other site 272123001867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123001868 nucleotide binding region [chemical binding]; other site 272123001869 ATP-binding site [chemical binding]; other site 272123001870 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272123001871 HRDC domain; Region: HRDC; pfam00570 272123001872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272123001873 DNA binding residues [nucleotide binding] 272123001874 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 272123001875 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 272123001876 acyl-activating enzyme (AAE) consensus motif; other site 272123001877 putative AMP binding site [chemical binding]; other site 272123001878 putative active site [active] 272123001879 putative CoA binding site [chemical binding]; other site 272123001880 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 272123001881 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272123001882 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272123001883 E3 interaction surface; other site 272123001884 lipoyl attachment site [posttranslational modification]; other site 272123001885 e3 binding domain; Region: E3_binding; pfam02817 272123001886 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272123001887 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272123001888 putative cation:proton antiport protein; Provisional; Region: PRK10669 272123001889 TrkA-N domain; Region: TrkA_N; pfam02254 272123001890 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 272123001891 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 272123001892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123001893 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123001894 putative active site [active] 272123001895 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 272123001896 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272123001897 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123001898 putative active site [active] 272123001899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123001900 putative active site [active] 272123001901 magnesium chelatase subunit H; Provisional; Region: PRK12493 272123001902 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123001903 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123001904 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123001905 putative active site [active] 272123001906 Cold shock proteins [Transcription]; Region: CspC; COG1278 272123001907 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 272123001908 GIY-YIG motif/motif A; other site 272123001909 active site 272123001910 catalytic site [active] 272123001911 metal binding site [ion binding]; metal-binding site 272123001912 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 272123001913 active site 272123001914 GIY-YIG motif/motif A; other site 272123001915 catalytic site [active] 272123001916 metal binding site [ion binding]; metal-binding site 272123001917 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123001918 oligomeric interface; other site 272123001919 putative active site [active] 272123001920 homodimer interface [polypeptide binding]; other site 272123001921 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123001922 oligomeric interface; other site 272123001923 putative active site [active] 272123001924 homodimer interface [polypeptide binding]; other site 272123001925 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 272123001926 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272123001927 cobalamin binding residues [chemical binding]; other site 272123001928 putative BtuC binding residues; other site 272123001929 dimer interface [polypeptide binding]; other site 272123001930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123001931 S-adenosylmethionine binding site [chemical binding]; other site 272123001932 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272123001933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272123001934 Zn2+ binding site [ion binding]; other site 272123001935 Mg2+ binding site [ion binding]; other site 272123001936 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272123001937 synthetase active site [active] 272123001938 NTP binding site [chemical binding]; other site 272123001939 metal binding site [ion binding]; metal-binding site 272123001940 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272123001941 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272123001942 HAMP domain; Region: HAMP; pfam00672 272123001943 dimerization interface [polypeptide binding]; other site 272123001944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123001945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272123001946 dimer interface [polypeptide binding]; other site 272123001947 phosphorylation site [posttranslational modification] 272123001948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123001949 ATP binding site [chemical binding]; other site 272123001950 Mg2+ binding site [ion binding]; other site 272123001951 G-X-G motif; other site 272123001952 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272123001953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272123001954 Walker A/P-loop; other site 272123001955 ATP binding site [chemical binding]; other site 272123001956 Q-loop/lid; other site 272123001957 ABC transporter signature motif; other site 272123001958 Walker B; other site 272123001959 D-loop; other site 272123001960 H-loop/switch region; other site 272123001961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272123001962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272123001963 Walker A/P-loop; other site 272123001964 ATP binding site [chemical binding]; other site 272123001965 Q-loop/lid; other site 272123001966 ABC transporter signature motif; other site 272123001967 Walker B; other site 272123001968 D-loop; other site 272123001969 H-loop/switch region; other site 272123001970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272123001971 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123001972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123001973 S-adenosylmethionine binding site [chemical binding]; other site 272123001974 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 272123001975 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272123001976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123001977 Coenzyme A binding pocket [chemical binding]; other site 272123001978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123001979 active site 272123001980 Pirin-related protein [General function prediction only]; Region: COG1741 272123001981 Pirin; Region: Pirin; pfam02678 272123001982 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272123001983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123001984 Mg2+ binding site [ion binding]; other site 272123001985 G-X-G motif; other site 272123001986 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272123001987 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272123001988 interchain domain interface [polypeptide binding]; other site 272123001989 intrachain domain interface; other site 272123001990 Qi binding site; other site 272123001991 Qo binding site; other site 272123001992 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272123001993 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272123001994 Qi binding site; other site 272123001995 intrachain domain interface; other site 272123001996 interchain domain interface [polypeptide binding]; other site 272123001997 heme bH binding site [chemical binding]; other site 272123001998 heme bL binding site [chemical binding]; other site 272123001999 Qo binding site; other site 272123002000 carboxyl-terminal processing protease; Provisional; Region: PLN00049 272123002001 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272123002002 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272123002003 protein binding site [polypeptide binding]; other site 272123002004 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272123002005 Catalytic dyad [active] 272123002006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123002007 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 272123002008 Peptidase family M50; Region: Peptidase_M50; pfam02163 272123002009 active site 272123002010 putative substrate binding region [chemical binding]; other site 272123002011 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272123002012 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272123002013 active site 272123002014 homodimer interface [polypeptide binding]; other site 272123002015 catalytic site [active] 272123002016 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123002017 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123002018 active site 272123002019 KGK domain; Region: KGK; pfam08872 272123002020 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 272123002021 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123002022 G1 box; other site 272123002023 GTP/Mg2+ binding site [chemical binding]; other site 272123002024 G2 box; other site 272123002025 Switch I region; other site 272123002026 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123002027 G3 box; other site 272123002028 Switch II region; other site 272123002029 G4 box; other site 272123002030 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272123002031 Peptidase family U32; Region: Peptidase_U32; pfam01136 272123002032 Collagenase; Region: DUF3656; pfam12392 272123002033 Peptidase family U32; Region: Peptidase_U32; cl03113 272123002034 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 272123002035 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123002036 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272123002037 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 272123002038 Putative restriction endonuclease; Region: Uma2; pfam05685 272123002039 putative active site [active] 272123002040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002041 binding surface 272123002042 TPR motif; other site 272123002043 TPR repeat; Region: TPR_11; pfam13414 272123002044 TPR repeat; Region: TPR_11; pfam13414 272123002045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002046 binding surface 272123002047 TPR motif; other site 272123002048 TPR repeat; Region: TPR_11; pfam13414 272123002049 GUN4-like; Region: GUN4; pfam05419 272123002050 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272123002051 Amidinotransferase; Region: Amidinotransf; cl12043 272123002052 Uncharacterized conserved protein [Function unknown]; Region: COG1915 272123002053 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 272123002054 homodimer interface [polypeptide binding]; other site 272123002055 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 272123002056 HEAT repeats; Region: HEAT_2; pfam13646 272123002057 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272123002058 AAA domain; Region: AAA_21; pfam13304 272123002059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123002060 Walker B; other site 272123002061 D-loop; other site 272123002062 H-loop/switch region; other site 272123002063 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 272123002064 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 272123002065 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123002066 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123002067 Predicted membrane protein [Function unknown]; Region: COG4280 272123002068 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002069 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002070 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002071 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002072 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002073 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002074 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002075 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002076 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002077 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002078 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002079 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002080 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002081 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002082 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002083 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002084 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272123002086 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123002087 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123002088 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002089 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002090 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002091 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002092 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002093 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002094 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002095 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002096 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002097 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002098 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123002099 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123002100 Cache domain; Region: Cache_1; pfam02743 272123002101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272123002102 PAS domain S-box; Region: sensory_box; TIGR00229 272123002103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123002104 putative active site [active] 272123002105 heme pocket [chemical binding]; other site 272123002106 PAS domain S-box; Region: sensory_box; TIGR00229 272123002107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123002108 putative active site [active] 272123002109 heme pocket [chemical binding]; other site 272123002110 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123002111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123002112 dimer interface [polypeptide binding]; other site 272123002113 phosphorylation site [posttranslational modification] 272123002114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002115 ATP binding site [chemical binding]; other site 272123002116 Mg2+ binding site [ion binding]; other site 272123002117 G-X-G motif; other site 272123002118 Response regulator receiver domain; Region: Response_reg; pfam00072 272123002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123002120 active site 272123002121 phosphorylation site [posttranslational modification] 272123002122 intermolecular recognition site; other site 272123002123 dimerization interface [polypeptide binding]; other site 272123002124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272123002125 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 272123002126 iron-sulfur cluster [ion binding]; other site 272123002127 [2Fe-2S] cluster binding site [ion binding]; other site 272123002128 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 272123002129 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123002130 putative active site [active] 272123002131 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123002132 G1 box; other site 272123002133 GTP/Mg2+ binding site [chemical binding]; other site 272123002134 G2 box; other site 272123002135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002136 TPR motif; other site 272123002137 TPR repeat; Region: TPR_11; pfam13414 272123002138 binding surface 272123002139 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 272123002140 putative dimer interface [polypeptide binding]; other site 272123002141 putative [2Fe-2S] cluster binding site [ion binding]; other site 272123002142 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 272123002143 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272123002144 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272123002145 proposed catalytic triad [active] 272123002146 conserved cys residue [active] 272123002147 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272123002148 dinuclear metal binding motif [ion binding]; other site 272123002149 Cupin domain; Region: Cupin_2; pfam07883 272123002150 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 272123002151 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272123002152 dimer interface [polypeptide binding]; other site 272123002153 catalytic residues [active] 272123002154 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272123002155 UreF; Region: UreF; pfam01730 272123002156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123002157 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 272123002158 active site flap/lid [active] 272123002159 nucleophilic elbow; other site 272123002160 catalytic triad [active] 272123002161 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 272123002162 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272123002163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123002164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123002165 Coenzyme A binding pocket [chemical binding]; other site 272123002166 apocytochrome f; Reviewed; Region: PRK02693 272123002167 cytochrome f; Region: petA; CHL00037 272123002168 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 272123002169 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 272123002170 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 272123002171 cytochrome b subunit interaction site [polypeptide binding]; other site 272123002172 [2Fe-2S] cluster binding site [ion binding]; other site 272123002173 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 272123002174 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272123002175 DHH family; Region: DHH; pfam01368 272123002176 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123002177 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123002178 active site 272123002179 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123002180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123002181 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272123002182 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 272123002183 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272123002184 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272123002185 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272123002186 lipoyl attachment site [posttranslational modification]; other site 272123002187 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123002188 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 272123002189 catalytic residue [active] 272123002190 YCII-related domain; Region: YCII; cl00999 272123002191 Uncharacterized conserved protein [Function unknown]; Region: COG3937 272123002192 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 272123002193 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123002194 active site 272123002195 ATP binding site [chemical binding]; other site 272123002196 substrate binding site [chemical binding]; other site 272123002197 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 272123002198 ResB-like family; Region: ResB; pfam05140 272123002199 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272123002200 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 272123002201 EamA-like transporter family; Region: EamA; pfam00892 272123002202 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272123002203 EamA-like transporter family; Region: EamA; pfam00892 272123002204 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 272123002205 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272123002206 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272123002207 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272123002208 Predicted membrane protein [Function unknown]; Region: COG2149 272123002209 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272123002210 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272123002211 dimer interface [polypeptide binding]; other site 272123002212 PYR/PP interface [polypeptide binding]; other site 272123002213 TPP binding site [chemical binding]; other site 272123002214 substrate binding site [chemical binding]; other site 272123002215 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272123002216 Domain of unknown function; Region: EKR; pfam10371 272123002217 4Fe-4S binding domain; Region: Fer4_6; pfam12837 272123002218 4Fe-4S binding domain; Region: Fer4; pfam00037 272123002219 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272123002220 TPP-binding site [chemical binding]; other site 272123002221 dimer interface [polypeptide binding]; other site 272123002222 Protein of unknown function (DUF433); Region: DUF433; cl01030 272123002223 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123002224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002226 binding surface 272123002227 TPR motif; other site 272123002228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002230 binding surface 272123002231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002232 TPR motif; other site 272123002233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002235 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123002236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002237 binding surface 272123002238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002239 TPR motif; other site 272123002240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002241 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002242 NB-ARC domain; Region: NB-ARC; pfam00931 272123002243 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 272123002244 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 272123002245 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 272123002246 putative rRNA binding site [nucleotide binding]; other site 272123002247 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 272123002248 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 272123002249 Repair protein; Region: Repair_PSII; pfam04536 272123002250 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 272123002251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272123002252 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272123002253 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 272123002254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 272123002255 Protein of unknown function, DUF482; Region: DUF482; pfam04339 272123002256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123002257 dimer interface [polypeptide binding]; other site 272123002258 phosphorylation site [posttranslational modification] 272123002259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002260 ATP binding site [chemical binding]; other site 272123002261 Mg2+ binding site [ion binding]; other site 272123002262 G-X-G motif; other site 272123002263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123002264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123002265 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 272123002266 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272123002267 dimerization interface [polypeptide binding]; other site 272123002268 active site 272123002269 metal binding site [ion binding]; metal-binding site 272123002270 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272123002271 dsRNA binding site [nucleotide binding]; other site 272123002272 Protein kinase domain; Region: Pkinase; pfam00069 272123002273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123002274 active site 272123002275 ATP binding site [chemical binding]; other site 272123002276 substrate binding site [chemical binding]; other site 272123002277 activation loop (A-loop); other site 272123002278 AAA ATPase domain; Region: AAA_16; pfam13191 272123002279 Predicted ATPase [General function prediction only]; Region: COG3899 272123002280 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123002281 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123002282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123002283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002284 ATP binding site [chemical binding]; other site 272123002285 Mg2+ binding site [ion binding]; other site 272123002286 G-X-G motif; other site 272123002287 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272123002288 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 272123002289 oligomer interface [polypeptide binding]; other site 272123002290 metal binding site [ion binding]; metal-binding site 272123002291 metal binding site [ion binding]; metal-binding site 272123002292 Cl binding site [ion binding]; other site 272123002293 aspartate ring; other site 272123002294 basic sphincter; other site 272123002295 putative hydrophobic gate; other site 272123002296 periplasmic entrance; other site 272123002297 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272123002298 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272123002299 Catalytic site [active] 272123002300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272123002301 dihydroorotase; Provisional; Region: PRK07575 272123002302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272123002303 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 272123002304 active site 272123002305 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272123002306 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 272123002307 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272123002308 putative substrate binding pocket [chemical binding]; other site 272123002309 dimer interface [polypeptide binding]; other site 272123002310 phosphate binding site [ion binding]; other site 272123002311 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272123002312 active site 272123002313 putative DNA-binding cleft [nucleotide binding]; other site 272123002314 dimer interface [polypeptide binding]; other site 272123002315 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123002316 Protein of unknown function DUF82; Region: DUF82; pfam01927 272123002317 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 272123002318 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272123002319 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 272123002320 CoA binding domain; Region: CoA_binding; smart00881 272123002321 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 272123002322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002324 binding surface 272123002325 TPR motif; other site 272123002326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002328 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123002329 putative active site [active] 272123002330 Restriction endonuclease; Region: Mrr_cat; pfam04471 272123002331 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 272123002332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 272123002333 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 272123002334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123002335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123002336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123002337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123002338 DNA binding residues [nucleotide binding] 272123002339 dimerization interface [polypeptide binding]; other site 272123002340 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272123002341 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 272123002342 putative substrate binding site [chemical binding]; other site 272123002343 putative ATP binding site [chemical binding]; other site 272123002344 HipA N-terminal domain; Region: Couple_hipA; cl11853 272123002345 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 272123002346 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272123002347 ATP-binding site [chemical binding]; other site 272123002348 Gluconate-6-phosphate binding site [chemical binding]; other site 272123002349 Shikimate kinase; Region: SKI; pfam01202 272123002350 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 272123002351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123002352 GAF domain; Region: GAF; pfam01590 272123002353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123002354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123002355 metal binding site [ion binding]; metal-binding site 272123002356 active site 272123002357 I-site; other site 272123002358 Biofilm formation and stress response factor; Region: BsmA; cl01794 272123002359 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 272123002360 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 272123002361 GTPase Era; Reviewed; Region: era; PRK00089 272123002362 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272123002363 G1 box; other site 272123002364 GTP/Mg2+ binding site [chemical binding]; other site 272123002365 Switch I region; other site 272123002366 G2 box; other site 272123002367 Switch II region; other site 272123002368 G3 box; other site 272123002369 G4 box; other site 272123002370 G5 box; other site 272123002371 KH domain; Region: KH_2; pfam07650 272123002372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123002373 catalytic core [active] 272123002374 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 272123002375 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 272123002376 DnaJ domain; Region: DnaJ; pfam00226 272123002377 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272123002378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272123002379 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123002380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272123002381 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123002382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123002383 active site 272123002384 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 272123002385 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 272123002386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123002387 active site 272123002388 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123002389 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123002390 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272123002391 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 272123002392 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 272123002393 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272123002394 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123002395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123002396 active site 272123002397 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272123002398 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272123002399 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 272123002400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123002401 Probable transposase; Region: OrfB_IS605; pfam01385 272123002402 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272123002403 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272123002404 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272123002405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123002406 putative metal binding site; other site 272123002407 Uncharacterized conserved protein [Function unknown]; Region: COG2928 272123002408 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272123002409 putative RNA binding site [nucleotide binding]; other site 272123002410 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272123002411 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272123002412 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272123002413 P loop; other site 272123002414 GTP binding site [chemical binding]; other site 272123002415 GAF domain; Region: GAF_3; pfam13492 272123002416 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123002417 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123002418 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002419 Restriction endonuclease; Region: Mrr_cat; pfam04471 272123002420 PIN domain; Region: PIN_3; pfam13470 272123002421 S-layer homology domain; Region: SLH; pfam00395 272123002422 S-layer homology domain; Region: SLH; pfam00395 272123002423 S-layer homology domain; Region: SLH; pfam00395 272123002424 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272123002425 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272123002426 TPP-binding site; other site 272123002427 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272123002428 PYR/PP interface [polypeptide binding]; other site 272123002429 dimer interface [polypeptide binding]; other site 272123002430 TPP binding site [chemical binding]; other site 272123002431 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272123002432 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 272123002433 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272123002434 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 272123002435 Walker A/P-loop; other site 272123002436 ATP binding site [chemical binding]; other site 272123002437 Q-loop/lid; other site 272123002438 ABC transporter signature motif; other site 272123002439 Walker B; other site 272123002440 D-loop; other site 272123002441 H-loop/switch region; other site 272123002442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123002443 dimer interface [polypeptide binding]; other site 272123002444 ABC-ATPase subunit interface; other site 272123002445 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272123002446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 272123002447 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 272123002448 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 272123002449 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 272123002450 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123002451 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 272123002452 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123002453 CHASE2 domain; Region: CHASE2; pfam05226 272123002454 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123002455 cyclase homology domain; Region: CHD; cd07302 272123002456 nucleotidyl binding site; other site 272123002457 metal binding site [ion binding]; metal-binding site 272123002458 dimer interface [polypeptide binding]; other site 272123002459 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 272123002460 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 272123002461 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123002462 AAA ATPase domain; Region: AAA_16; pfam13191 272123002463 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123002464 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123002465 active site 272123002466 MraW methylase family; Region: Methyltransf_5; cl17771 272123002467 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272123002468 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 272123002469 four helix bundle protein; Region: TIGR02436 272123002470 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272123002471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272123002472 Walker A/P-loop; other site 272123002473 ATP binding site [chemical binding]; other site 272123002474 Q-loop/lid; other site 272123002475 ABC transporter signature motif; other site 272123002476 Walker B; other site 272123002477 D-loop; other site 272123002478 H-loop/switch region; other site 272123002479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272123002480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272123002481 Walker A/P-loop; other site 272123002482 ATP binding site [chemical binding]; other site 272123002483 Q-loop/lid; other site 272123002484 ABC transporter signature motif; other site 272123002485 Walker B; other site 272123002486 D-loop; other site 272123002487 H-loop/switch region; other site 272123002488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272123002489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002491 binding surface 272123002492 TPR motif; other site 272123002493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123002496 binding surface 272123002497 TPR motif; other site 272123002498 AAA domain; Region: AAA_21; pfam13304 272123002499 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 272123002500 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272123002501 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272123002502 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272123002503 ThiS interaction site; other site 272123002504 putative active site [active] 272123002505 tetramer interface [polypeptide binding]; other site 272123002506 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272123002507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123002508 Probable transposase; Region: OrfB_IS605; pfam01385 272123002509 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123002510 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123002511 catalytic loop [active] 272123002512 iron binding site [ion binding]; other site 272123002513 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 272123002514 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 272123002515 active site 272123002516 catalytic residues [active] 272123002517 metal binding site [ion binding]; metal-binding site 272123002518 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272123002519 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272123002520 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272123002521 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272123002522 protein binding site [polypeptide binding]; other site 272123002523 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 272123002524 putative homodimer interface [polypeptide binding]; other site 272123002525 putative homotetramer interface [polypeptide binding]; other site 272123002526 putative allosteric switch controlling residues; other site 272123002527 putative metal binding site [ion binding]; other site 272123002528 putative homodimer-homodimer interface [polypeptide binding]; other site 272123002529 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 272123002530 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 272123002531 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272123002532 catalytic residue [active] 272123002533 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272123002534 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272123002535 NAD(P) binding site [chemical binding]; other site 272123002536 putative active site [active] 272123002537 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 272123002538 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 272123002539 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272123002540 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272123002541 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272123002542 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272123002543 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272123002544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272123002545 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272123002546 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272123002547 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272123002548 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002549 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cd09852 272123002550 putative active site [active] 272123002551 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272123002552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123002553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123002554 ATP binding site [chemical binding]; other site 272123002555 putative Mg++ binding site [ion binding]; other site 272123002556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123002557 nucleotide binding region [chemical binding]; other site 272123002558 ATP-binding site [chemical binding]; other site 272123002559 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 272123002560 homotrimer interaction site [polypeptide binding]; other site 272123002561 putative active site [active] 272123002562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123002563 active site 272123002564 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272123002565 DNA protecting protein DprA; Region: dprA; TIGR00732 272123002566 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 272123002567 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 272123002568 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272123002569 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123002570 cofactor binding site; other site 272123002571 DNA binding site [nucleotide binding] 272123002572 substrate interaction site [chemical binding]; other site 272123002573 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123002574 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002575 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272123002577 septum formation inhibitor; Reviewed; Region: minC; PRK00513 272123002578 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272123002579 septum site-determining protein MinD; Region: minD_bact; TIGR01968 272123002580 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272123002581 Switch I; other site 272123002582 Switch II; other site 272123002583 cell division topological specificity factor MinE; Provisional; Region: PRK13988 272123002584 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 272123002585 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 272123002586 Protein of unknown function, DUF608; Region: DUF608; pfam04685 272123002587 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 272123002588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123002589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123002590 active site 272123002591 catalytic tetrad [active] 272123002592 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 272123002593 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 272123002594 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123002595 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 272123002596 cofactor binding site; other site 272123002597 DNA binding site [nucleotide binding] 272123002598 substrate interaction site [chemical binding]; other site 272123002599 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 272123002600 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 272123002601 G1 box; other site 272123002602 GTP/Mg2+ binding site [chemical binding]; other site 272123002603 G2 box; other site 272123002604 Switch I region; other site 272123002605 G3 box; other site 272123002606 Switch II region; other site 272123002607 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 272123002608 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 272123002609 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 272123002610 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272123002611 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272123002612 putative NAD(P) binding site [chemical binding]; other site 272123002613 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 272123002614 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 272123002615 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 272123002616 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 272123002617 protein I interface; other site 272123002618 D2 interface; other site 272123002619 protein T interface; other site 272123002620 chlorophyll binding site; other site 272123002621 beta carotene binding site; other site 272123002622 pheophytin binding site; other site 272123002623 manganese-stabilizing polypeptide interface; other site 272123002624 CP43 interface; other site 272123002625 protein L interface; other site 272123002626 oxygen evolving complex binding site; other site 272123002627 bromide binding site; other site 272123002628 quinone binding site; other site 272123002629 Fe binding site [ion binding]; other site 272123002630 core light harvesting interface; other site 272123002631 cytochrome b559 alpha subunit interface; other site 272123002632 cytochrome c-550 interface; other site 272123002633 protein J interface; other site 272123002634 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272123002635 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272123002636 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123002637 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272123002638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123002639 motif II; other site 272123002640 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272123002641 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272123002642 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 272123002643 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 272123002644 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002645 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 272123002646 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 272123002647 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123002648 putative active site [active] 272123002649 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272123002650 nudix motif; other site 272123002651 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 272123002652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002653 TPR motif; other site 272123002654 binding surface 272123002655 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272123002656 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272123002657 Walker A/P-loop; other site 272123002658 ATP binding site [chemical binding]; other site 272123002659 Q-loop/lid; other site 272123002660 ABC transporter signature motif; other site 272123002661 Walker B; other site 272123002662 D-loop; other site 272123002663 H-loop/switch region; other site 272123002664 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 272123002665 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 272123002666 AAA ATPase domain; Region: AAA_16; pfam13191 272123002667 AAA domain; Region: AAA_22; pfam13401 272123002668 Walker A motif; other site 272123002669 ATP binding site [chemical binding]; other site 272123002670 Walker B motif; other site 272123002671 arginine finger; other site 272123002672 AAA ATPase domain; Region: AAA_16; pfam13191 272123002673 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272123002674 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123002675 putative active site [active] 272123002676 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123002677 putative active site [active] 272123002678 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123002679 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272123002680 isocitrate dehydrogenase; Validated; Region: PRK07362 272123002681 GUN4-like; Region: GUN4; pfam05419 272123002682 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 272123002683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123002684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123002685 dimer interface [polypeptide binding]; other site 272123002686 phosphorylation site [posttranslational modification] 272123002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002688 ATP binding site [chemical binding]; other site 272123002689 Mg2+ binding site [ion binding]; other site 272123002690 G-X-G motif; other site 272123002691 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272123002692 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272123002693 Walker A/P-loop; other site 272123002694 ATP binding site [chemical binding]; other site 272123002695 Q-loop/lid; other site 272123002696 ABC transporter signature motif; other site 272123002697 Walker B; other site 272123002698 D-loop; other site 272123002699 H-loop/switch region; other site 272123002700 TOBE domain; Region: TOBE_2; pfam08402 272123002701 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123002702 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 272123002703 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272123002704 RNA binding site [nucleotide binding]; other site 272123002705 active site 272123002706 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 272123002707 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 272123002708 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 272123002709 EamA-like transporter family; Region: EamA; pfam00892 272123002710 Transposase IS200 like; Region: Y1_Tnp; cl00848 272123002711 Transposase IS200 like; Region: Y1_Tnp; cl00848 272123002712 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272123002713 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272123002714 nucleotide binding pocket [chemical binding]; other site 272123002715 K-X-D-G motif; other site 272123002716 catalytic site [active] 272123002717 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272123002718 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272123002719 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272123002720 Dimer interface [polypeptide binding]; other site 272123002721 BRCT sequence motif; other site 272123002722 von Willebrand factor type A domain; Region: VWA_2; pfam13519 272123002723 metal ion-dependent adhesion site (MIDAS); other site 272123002724 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272123002725 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272123002726 putative active site [active] 272123002727 substrate binding site [chemical binding]; other site 272123002728 putative cosubstrate binding site; other site 272123002729 catalytic site [active] 272123002730 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272123002731 substrate binding site [chemical binding]; other site 272123002732 AAA ATPase domain; Region: AAA_16; pfam13191 272123002733 WD domain, G-beta repeat; Region: WD40; pfam00400 272123002734 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123002735 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123002736 structural tetrad; other site 272123002737 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123002738 structural tetrad; other site 272123002739 WD40 repeats; Region: WD40; smart00320 272123002740 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 272123002741 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 272123002742 putative phosphoketolase; Provisional; Region: PRK05261 272123002743 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 272123002744 TPP-binding site; other site 272123002745 XFP C-terminal domain; Region: XFP_C; pfam09363 272123002746 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272123002747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272123002748 active site residue [active] 272123002749 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 272123002750 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272123002751 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 272123002752 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272123002753 trimer interface [polypeptide binding]; other site 272123002754 active site 272123002755 substrate binding site [chemical binding]; other site 272123002756 CoA binding site [chemical binding]; other site 272123002757 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272123002758 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 272123002759 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 272123002760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002761 binding surface 272123002762 TPR motif; other site 272123002763 TPR repeat; Region: TPR_11; pfam13414 272123002764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002765 binding surface 272123002766 TPR motif; other site 272123002767 TPR repeat; Region: TPR_11; pfam13414 272123002768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002769 binding surface 272123002770 TPR motif; other site 272123002771 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123002772 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272123002773 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123002774 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123002775 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123002776 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 272123002777 AMP binding site [chemical binding]; other site 272123002778 metal binding site [ion binding]; metal-binding site 272123002779 active site 272123002780 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 272123002781 putative active site [active] 272123002782 transaldolase; Provisional; Region: PRK03903 272123002783 catalytic residue [active] 272123002784 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272123002785 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272123002786 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272123002787 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 272123002788 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123002789 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 272123002790 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 272123002791 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123002792 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272123002793 catalytic triad [active] 272123002794 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123002795 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123002796 ligand binding site [chemical binding]; other site 272123002797 flexible hinge region; other site 272123002798 CHAT domain; Region: CHAT; pfam12770 272123002799 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 272123002800 hypothetical protein; Provisional; Region: PRK02509 272123002801 Uncharacterized conserved protein [Function unknown]; Region: COG1615 272123002802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123002803 AAA domain; Region: AAA_23; pfam13476 272123002804 Walker A/P-loop; other site 272123002805 ATP binding site [chemical binding]; other site 272123002806 AAA domain; Region: AAA_21; pfam13304 272123002807 Muconolactone delta-isomerase; Region: MIase; cl01992 272123002808 Photosystem II protein; Region: PSII; cl08223 272123002809 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 272123002810 flavodoxin FldA; Validated; Region: PRK09267 272123002811 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 272123002812 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 272123002813 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 272123002814 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272123002815 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272123002816 TLC ATP/ADP transporter; Region: TLC; cl03940 272123002817 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272123002818 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272123002819 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272123002820 hydrolase, alpha/beta fold family protein; Region: PLN02824 272123002821 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272123002822 outer membrane lipoprotein; Provisional; Region: PRK11023 272123002823 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 272123002824 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272123002825 putative valine binding site [chemical binding]; other site 272123002826 dimer interface [polypeptide binding]; other site 272123002827 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272123002828 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 272123002829 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 272123002830 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272123002831 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 272123002832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272123002833 putative NAD(P) binding site [chemical binding]; other site 272123002834 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 272123002835 Response regulator receiver domain; Region: Response_reg; pfam00072 272123002836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123002837 active site 272123002838 phosphorylation site [posttranslational modification] 272123002839 intermolecular recognition site; other site 272123002840 dimerization interface [polypeptide binding]; other site 272123002841 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272123002842 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272123002843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272123002844 dimer interface [polypeptide binding]; other site 272123002845 putative CheW interface [polypeptide binding]; other site 272123002846 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272123002847 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123002848 putative binding surface; other site 272123002849 active site 272123002850 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272123002851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002852 ATP binding site [chemical binding]; other site 272123002853 Mg2+ binding site [ion binding]; other site 272123002854 G-X-G motif; other site 272123002855 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272123002856 Response regulator receiver domain; Region: Response_reg; pfam00072 272123002857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123002858 active site 272123002859 phosphorylation site [posttranslational modification] 272123002860 intermolecular recognition site; other site 272123002861 dimerization interface [polypeptide binding]; other site 272123002862 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 272123002863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123002864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123002865 Coenzyme A binding pocket [chemical binding]; other site 272123002866 transketolase; Reviewed; Region: PRK05899 272123002867 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272123002868 TPP-binding site [chemical binding]; other site 272123002869 dimer interface [polypeptide binding]; other site 272123002870 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272123002871 PYR/PP interface [polypeptide binding]; other site 272123002872 dimer interface [polypeptide binding]; other site 272123002873 TPP binding site [chemical binding]; other site 272123002874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272123002875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002877 binding surface 272123002878 TPR motif; other site 272123002879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002882 binding surface 272123002883 TPR motif; other site 272123002884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002885 TPR repeat; Region: TPR_11; pfam13414 272123002886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002887 binding surface 272123002888 TPR motif; other site 272123002889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002891 binding surface 272123002892 TPR motif; other site 272123002893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002894 CHAT domain; Region: CHAT; pfam12770 272123002895 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002897 binding surface 272123002898 TPR motif; other site 272123002899 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002902 binding surface 272123002903 TPR motif; other site 272123002904 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002906 binding surface 272123002907 TPR motif; other site 272123002908 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002909 CHAT domain; Region: CHAT; pfam12770 272123002910 DevC protein; Region: devC; TIGR01185 272123002911 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123002912 FtsX-like permease family; Region: FtsX; pfam02687 272123002913 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123002914 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123002915 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123002916 Predicted transcriptional regulators [Transcription]; Region: COG1695 272123002917 Transcriptional regulator PadR-like family; Region: PadR; cl17335 272123002918 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272123002919 PRC-barrel domain; Region: PRC; pfam05239 272123002920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 272123002921 PRC-barrel domain; Region: PRC; pfam05239 272123002922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 272123002923 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 272123002924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123002925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272123002926 putative substrate translocation pore; other site 272123002927 Inward rectifier potassium channel; Region: IRK; pfam01007 272123002928 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 272123002929 active site 272123002930 catalytic residues [active] 272123002931 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 272123002932 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272123002933 tetramer interface [polypeptide binding]; other site 272123002934 TPP-binding site [chemical binding]; other site 272123002935 heterodimer interface [polypeptide binding]; other site 272123002936 phosphorylation loop region [posttranslational modification] 272123002937 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123002938 HSP70 interaction site [polypeptide binding]; other site 272123002939 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 272123002940 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272123002941 arginine-tRNA ligase; Region: PLN02286 272123002942 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272123002943 active site 272123002944 HIGH motif; other site 272123002945 KMSK motif region; other site 272123002946 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272123002947 tRNA binding surface [nucleotide binding]; other site 272123002948 anticodon binding site; other site 272123002949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002950 TPR motif; other site 272123002951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002952 binding surface 272123002953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002955 binding surface 272123002956 TPR motif; other site 272123002957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002959 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123002960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002961 binding surface 272123002962 TPR motif; other site 272123002963 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123002965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123002966 binding surface 272123002967 TPR motif; other site 272123002968 TPR repeat; Region: TPR_11; pfam13414 272123002969 AAA ATPase domain; Region: AAA_16; pfam13191 272123002970 AAA domain; Region: AAA_22; pfam13401 272123002971 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123002972 putative active site [active] 272123002973 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 272123002974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123002975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123002976 active site 272123002977 phosphorylation site [posttranslational modification] 272123002978 intermolecular recognition site; other site 272123002979 dimerization interface [polypeptide binding]; other site 272123002980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123002981 DNA binding site [nucleotide binding] 272123002982 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272123002983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123002984 dimerization interface [polypeptide binding]; other site 272123002985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123002986 dimer interface [polypeptide binding]; other site 272123002987 phosphorylation site [posttranslational modification] 272123002988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123002989 ATP binding site [chemical binding]; other site 272123002990 Mg2+ binding site [ion binding]; other site 272123002991 G-X-G motif; other site 272123002992 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 272123002993 protein I interface; other site 272123002994 D2 interface; other site 272123002995 protein T interface; other site 272123002996 chlorophyll binding site; other site 272123002997 beta carotene binding site; other site 272123002998 pheophytin binding site; other site 272123002999 manganese-stabilizing polypeptide interface; other site 272123003000 CP43 interface; other site 272123003001 protein L interface; other site 272123003002 oxygen evolving complex binding site; other site 272123003003 bromide binding site; other site 272123003004 quinone binding site; other site 272123003005 Fe binding site [ion binding]; other site 272123003006 core light harvesting interface; other site 272123003007 cytochrome b559 alpha subunit interface; other site 272123003008 cytochrome c-550 interface; other site 272123003009 protein J interface; other site 272123003010 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 272123003011 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 272123003012 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272123003013 iron-sulfur cluster [ion binding]; other site 272123003014 [2Fe-2S] cluster binding site [ion binding]; other site 272123003015 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272123003016 active site residue [active] 272123003017 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 272123003018 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 272123003019 active pocket/dimerization site; other site 272123003020 active site 272123003021 phosphorylation site [posttranslational modification] 272123003022 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272123003023 regulatory protein interface [polypeptide binding]; other site 272123003024 active site 272123003025 regulatory phosphorylation site [posttranslational modification]; other site 272123003026 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272123003027 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272123003028 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272123003029 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272123003030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272123003031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 272123003032 putative acyl-acceptor binding pocket; other site 272123003033 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 272123003034 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 272123003035 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123003036 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123003037 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123003038 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 272123003039 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 272123003040 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 272123003041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123003042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123003043 ATP binding site [chemical binding]; other site 272123003044 Mg2+ binding site [ion binding]; other site 272123003045 G-X-G motif; other site 272123003046 Uncharacterized conserved protein [Function unknown]; Region: COG3287 272123003047 FIST N domain; Region: FIST; pfam08495 272123003048 FIST C domain; Region: FIST_C; pfam10442 272123003049 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272123003050 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272123003051 nucleotide binding site [chemical binding]; other site 272123003052 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272123003053 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272123003054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123003055 catalytic residue [active] 272123003056 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 272123003057 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123003058 putative active site [active] 272123003059 putative metal binding site [ion binding]; other site 272123003060 quinolinate synthetase; Provisional; Region: PRK09375 272123003061 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123003062 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123003063 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123003064 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123003065 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123003066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123003067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272123003068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123003069 dimerization interface [polypeptide binding]; other site 272123003070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123003071 putative active site [active] 272123003072 heme pocket [chemical binding]; other site 272123003073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123003074 dimer interface [polypeptide binding]; other site 272123003075 phosphorylation site [posttranslational modification] 272123003076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123003077 ATP binding site [chemical binding]; other site 272123003078 Mg2+ binding site [ion binding]; other site 272123003079 G-X-G motif; other site 272123003080 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272123003081 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272123003082 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272123003083 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272123003084 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123003085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123003086 NAD(P) binding site [chemical binding]; other site 272123003087 active site 272123003088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123003089 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123003090 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123003091 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123003092 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 272123003093 FOG: CBS domain [General function prediction only]; Region: COG0517 272123003094 FOG: CBS domain [General function prediction only]; Region: COG0517 272123003095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 272123003096 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123003097 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123003098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272123003099 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123003100 putative active site [active] 272123003101 heme pocket [chemical binding]; other site 272123003102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272123003103 putative active site [active] 272123003104 heme pocket [chemical binding]; other site 272123003105 PAS domain S-box; Region: sensory_box; TIGR00229 272123003106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123003107 putative active site [active] 272123003108 heme pocket [chemical binding]; other site 272123003109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123003110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123003111 dimer interface [polypeptide binding]; other site 272123003112 phosphorylation site [posttranslational modification] 272123003113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123003114 ATP binding site [chemical binding]; other site 272123003115 Mg2+ binding site [ion binding]; other site 272123003116 G-X-G motif; other site 272123003117 Response regulator receiver domain; Region: Response_reg; pfam00072 272123003118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123003119 active site 272123003120 phosphorylation site [posttranslational modification] 272123003121 intermolecular recognition site; other site 272123003122 dimerization interface [polypeptide binding]; other site 272123003123 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 272123003124 DNA photolyase; Region: DNA_photolyase; pfam00875 272123003125 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 272123003126 Cupin domain; Region: Cupin_2; cl17218 272123003127 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272123003128 putative cation:proton antiport protein; Provisional; Region: PRK10669 272123003129 TrkA-N domain; Region: TrkA_N; pfam02254 272123003130 TrkA-C domain; Region: TrkA_C; pfam02080 272123003131 TrkA-C domain; Region: TrkA_C; pfam02080 272123003132 Sm and related proteins; Region: Sm_like; cl00259 272123003133 heptamer interface [polypeptide binding]; other site 272123003134 Sm1 motif; other site 272123003135 hexamer interface [polypeptide binding]; other site 272123003136 RNA binding site [nucleotide binding]; other site 272123003137 Sm2 motif; other site 272123003138 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272123003139 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272123003140 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272123003141 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272123003142 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272123003143 substrate binding site [chemical binding]; other site 272123003144 dimer interface [polypeptide binding]; other site 272123003145 ATP binding site [chemical binding]; other site 272123003146 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 272123003147 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 272123003148 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 272123003149 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272123003150 nucleoside/Zn binding site; other site 272123003151 dimer interface [polypeptide binding]; other site 272123003152 catalytic motif [active] 272123003153 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 272123003154 active site 272123003155 dimerization interface [polypeptide binding]; other site 272123003156 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272123003157 dimer interface [polypeptide binding]; other site 272123003158 ADP-ribose binding site [chemical binding]; other site 272123003159 active site 272123003160 nudix motif; other site 272123003161 metal binding site [ion binding]; metal-binding site 272123003162 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272123003163 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272123003164 active site 272123003165 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 272123003166 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003167 putative active site [active] 272123003168 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272123003169 enoyl-CoA hydratase; Provisional; Region: PRK05870 272123003170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272123003171 substrate binding site [chemical binding]; other site 272123003172 oxyanion hole (OAH) forming residues; other site 272123003173 trimer interface [polypeptide binding]; other site 272123003174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 272123003175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272123003176 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 272123003177 NADP binding site [chemical binding]; other site 272123003178 homodimer interface [polypeptide binding]; other site 272123003179 active site 272123003180 substrate binding site [chemical binding]; other site 272123003181 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123003182 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123003183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272123003184 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272123003185 Thioredoxin; Region: Thioredoxin_4; cl17273 272123003186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123003187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123003188 active site 272123003189 phosphorylation site [posttranslational modification] 272123003190 intermolecular recognition site; other site 272123003191 dimerization interface [polypeptide binding]; other site 272123003192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123003193 DNA binding residues [nucleotide binding] 272123003194 dimerization interface [polypeptide binding]; other site 272123003195 Protein kinase domain; Region: Pkinase; pfam00069 272123003196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123003197 active site 272123003198 ATP binding site [chemical binding]; other site 272123003199 substrate binding site [chemical binding]; other site 272123003200 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123003201 substrate binding site [chemical binding]; other site 272123003202 activation loop (A-loop); other site 272123003203 activation loop (A-loop); other site 272123003204 AAA ATPase domain; Region: AAA_16; pfam13191 272123003205 Predicted ATPase [General function prediction only]; Region: COG3899 272123003206 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123003207 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123003208 PAS fold; Region: PAS_4; pfam08448 272123003209 PAS fold; Region: PAS_4; pfam08448 272123003210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123003211 putative active site [active] 272123003212 heme pocket [chemical binding]; other site 272123003213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272123003214 Histidine kinase; Region: HisKA_3; pfam07730 272123003215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123003216 ATP binding site [chemical binding]; other site 272123003217 Mg2+ binding site [ion binding]; other site 272123003218 G-X-G motif; other site 272123003219 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 272123003220 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272123003221 TAP-like protein; Region: Abhydrolase_4; pfam08386 272123003222 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272123003223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272123003224 DNA-binding site [nucleotide binding]; DNA binding site 272123003225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123003226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123003227 homodimer interface [polypeptide binding]; other site 272123003228 catalytic residue [active] 272123003229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123003230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123003231 Coenzyme A binding pocket [chemical binding]; other site 272123003232 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 272123003233 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 272123003234 Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...; Region: GLECT; cd00070 272123003235 putative alternate dimerization interface [polypeptide binding]; other site 272123003236 sugar binding pocket [chemical binding]; other site 272123003237 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272123003238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123003239 active site 272123003240 metal binding site [ion binding]; metal-binding site 272123003241 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272123003242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123003243 ATP binding site [chemical binding]; other site 272123003244 putative Mg++ binding site [ion binding]; other site 272123003245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123003246 nucleotide binding region [chemical binding]; other site 272123003247 ATP-binding site [chemical binding]; other site 272123003248 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 272123003249 Uncharacterized conserved protein [Function unknown]; Region: COG2361 272123003250 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272123003251 active site 272123003252 NTP binding site [chemical binding]; other site 272123003253 metal binding triad [ion binding]; metal-binding site 272123003254 antibiotic binding site [chemical binding]; other site 272123003255 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272123003256 putative addiction module antidote; Region: doc_partner; TIGR02609 272123003257 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272123003258 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123003259 active site 272123003260 DNA binding site [nucleotide binding] 272123003261 Int/Topo IB signature motif; other site 272123003262 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272123003263 Trehalase; Region: Trehalase; cl17346 272123003264 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 272123003265 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272123003266 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 272123003267 active site 272123003268 catalytic site [active] 272123003269 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 272123003270 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 272123003271 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 272123003272 catalytic site [active] 272123003273 active site 272123003274 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272123003275 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 272123003276 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272123003277 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272123003278 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272123003279 Calx-beta domain; Region: Calx-beta; cl02522 272123003280 Calx-beta domain; Region: Calx-beta; cl02522 272123003281 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123003282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123003283 membrane-bound complex binding site; other site 272123003284 hinge residues; other site 272123003285 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272123003286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123003287 substrate binding pocket [chemical binding]; other site 272123003288 membrane-bound complex binding site; other site 272123003289 hinge residues; other site 272123003290 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123003291 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123003292 active site 272123003293 catalytic residues [active] 272123003294 DNA binding site [nucleotide binding] 272123003295 Int/Topo IB signature motif; other site 272123003296 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 272123003297 ArsC family; Region: ArsC; pfam03960 272123003298 catalytic residue [active] 272123003299 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 272123003300 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 272123003301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123003302 metal ion-dependent adhesion site (MIDAS); other site 272123003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123003304 MoxR-like ATPases [General function prediction only]; Region: COG0714 272123003305 Walker A motif; other site 272123003306 ATP binding site [chemical binding]; other site 272123003307 Walker B motif; other site 272123003308 arginine finger; other site 272123003309 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272123003310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123003311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123003312 non-specific DNA binding site [nucleotide binding]; other site 272123003313 salt bridge; other site 272123003314 sequence-specific DNA binding site [nucleotide binding]; other site 272123003315 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272123003316 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 272123003317 5' RNA guide strand anchoring site; other site 272123003318 active site 272123003319 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 272123003320 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272123003321 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123003322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123003323 salt bridge; other site 272123003324 non-specific DNA binding site [nucleotide binding]; other site 272123003325 sequence-specific DNA binding site [nucleotide binding]; other site 272123003326 Double zinc ribbon; Region: DZR; pfam12773 272123003327 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272123003328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123003329 active site 272123003330 DNA binding site [nucleotide binding] 272123003331 Int/Topo IB signature motif; other site 272123003332 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272123003333 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272123003334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123003335 nucleotide binding region [chemical binding]; other site 272123003336 ATP-binding site [chemical binding]; other site 272123003337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123003338 TPR motif; other site 272123003339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003340 binding surface 272123003341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123003343 binding surface 272123003344 TPR motif; other site 272123003345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123003348 binding surface 272123003349 TPR motif; other site 272123003350 CHAT domain; Region: CHAT; pfam12770 272123003351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123003352 binding surface 272123003353 TPR motif; other site 272123003354 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123003358 binding surface 272123003359 TPR motif; other site 272123003360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123003361 DNA polymerase III subunit delta; Validated; Region: PRK07452 272123003362 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272123003363 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 272123003364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123003365 Walker A motif; other site 272123003366 ATP binding site [chemical binding]; other site 272123003367 Walker B motif; other site 272123003368 arginine finger; other site 272123003369 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272123003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 272123003371 TniQ; Region: TniQ; pfam06527 272123003372 Integrase core domain; Region: rve; pfam00665 272123003373 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 272123003374 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 272123003375 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 272123003376 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272123003377 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 272123003378 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123003379 oligomeric interface; other site 272123003380 putative active site [active] 272123003381 homodimer interface [polypeptide binding]; other site 272123003382 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123003383 active site 272123003384 catalytic residues [active] 272123003385 DNA binding site [nucleotide binding] 272123003386 Int/Topo IB signature motif; other site 272123003387 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123003388 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123003389 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272123003390 ligand binding site [chemical binding]; other site 272123003391 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272123003392 putative switch regulator; other site 272123003393 non-specific DNA interactions [nucleotide binding]; other site 272123003394 DNA binding site [nucleotide binding] 272123003395 sequence specific DNA binding site [nucleotide binding]; other site 272123003396 putative cAMP binding site [chemical binding]; other site 272123003397 Rrf2 family protein; Region: rrf2_super; TIGR00738 272123003398 Transcriptional regulator; Region: Rrf2; pfam02082 272123003399 Transcriptional regulator; Region: Rrf2; cl17282 272123003400 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123003401 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123003402 dimer interface [polypeptide binding]; other site 272123003403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123003404 catalytic residue [active] 272123003405 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272123003406 Cadmium resistance transporter; Region: Cad; pfam03596 272123003407 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272123003408 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272123003409 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272123003410 Cadmium resistance transporter; Region: Cad; pfam03596 272123003411 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272123003412 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272123003413 active site 272123003414 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272123003415 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 272123003416 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272123003417 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272123003418 Cadmium resistance transporter; Region: Cad; pfam03596 272123003419 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272123003420 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 272123003421 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 272123003422 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123003423 Ferredoxin [Energy production and conversion]; Region: COG1146 272123003424 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272123003425 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 272123003426 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272123003427 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272123003428 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 272123003429 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 272123003430 putative NAD(P) binding site [chemical binding]; other site 272123003431 putative active site [active] 272123003432 Putative methyltransferase; Region: Methyltransf_20; pfam12147 272123003433 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 272123003434 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272123003435 tetramer interface [polypeptide binding]; other site 272123003436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123003437 catalytic residue [active] 272123003438 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123003439 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123003440 active site 272123003441 catalytic tetrad [active] 272123003442 S-layer homology domain; Region: SLH; pfam00395 272123003443 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123003444 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272123003445 dimer interface [polypeptide binding]; other site 272123003446 FMN binding site [chemical binding]; other site 272123003447 NADPH bind site [chemical binding]; other site 272123003448 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 272123003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123003450 Walker A/P-loop; other site 272123003451 ATP binding site [chemical binding]; other site 272123003452 Q-loop/lid; other site 272123003453 ABC transporter signature motif; other site 272123003454 Walker B; other site 272123003455 D-loop; other site 272123003456 H-loop/switch region; other site 272123003457 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272123003458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123003459 substrate binding pocket [chemical binding]; other site 272123003460 membrane-bound complex binding site; other site 272123003461 hinge residues; other site 272123003462 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272123003463 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 272123003464 active site 272123003465 iron coordination sites [ion binding]; other site 272123003466 substrate binding pocket [chemical binding]; other site 272123003467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123003468 S-adenosylmethionine binding site [chemical binding]; other site 272123003469 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272123003470 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123003471 substrate binding pocket [chemical binding]; other site 272123003472 membrane-bound complex binding site; other site 272123003473 hinge residues; other site 272123003474 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272123003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123003476 dimer interface [polypeptide binding]; other site 272123003477 conserved gate region; other site 272123003478 putative PBP binding loops; other site 272123003479 ABC-ATPase subunit interface; other site 272123003480 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 272123003481 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272123003482 active site 272123003483 dimer interface [polypeptide binding]; other site 272123003484 non-prolyl cis peptide bond; other site 272123003485 insertion regions; other site 272123003486 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 272123003487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272123003488 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272123003489 PBP superfamily domain; Region: PBP_like; cl17867 272123003490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123003491 putative active site [active] 272123003492 heme pocket [chemical binding]; other site 272123003493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123003494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123003495 dimer interface [polypeptide binding]; other site 272123003496 phosphorylation site [posttranslational modification] 272123003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123003498 ATP binding site [chemical binding]; other site 272123003499 Mg2+ binding site [ion binding]; other site 272123003500 G-X-G motif; other site 272123003501 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272123003502 MgtC family; Region: MgtC; pfam02308 272123003503 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272123003504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123003505 active site 272123003506 motif I; other site 272123003507 motif II; other site 272123003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123003509 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123003510 putative substrate translocation pore; other site 272123003511 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272123003512 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 272123003513 NADP binding site [chemical binding]; other site 272123003514 homotetramer interface [polypeptide binding]; other site 272123003515 homodimer interface [polypeptide binding]; other site 272123003516 active site 272123003517 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 272123003518 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272123003519 AAA ATPase domain; Region: AAA_16; pfam13191 272123003520 NACHT domain; Region: NACHT; pfam05729 272123003521 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272123003522 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123003523 structural tetrad; other site 272123003524 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123003525 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123003526 structural tetrad; other site 272123003527 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 272123003528 O-methyltransferase; Region: Methyltransf_2; pfam00891 272123003529 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 272123003530 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 272123003531 active site 272123003532 catalytic triad [active] 272123003533 oxyanion hole [active] 272123003534 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272123003535 active site 272123003536 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 272123003537 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272123003538 PYR/PP interface [polypeptide binding]; other site 272123003539 dimer interface [polypeptide binding]; other site 272123003540 TPP binding site [chemical binding]; other site 272123003541 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272123003542 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 272123003543 TPP-binding site [chemical binding]; other site 272123003544 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123003545 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123003546 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123003547 DevC protein; Region: devC; TIGR01185 272123003548 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123003549 FtsX-like permease family; Region: FtsX; pfam02687 272123003550 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 272123003551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123003552 Walker A/P-loop; other site 272123003553 ATP binding site [chemical binding]; other site 272123003554 Q-loop/lid; other site 272123003555 ABC transporter signature motif; other site 272123003556 Walker B; other site 272123003557 D-loop; other site 272123003558 H-loop/switch region; other site 272123003559 hypothetical protein; Region: PHA01623 272123003560 Response regulator receiver domain; Region: Response_reg; pfam00072 272123003561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123003562 active site 272123003563 phosphorylation site [posttranslational modification] 272123003564 intermolecular recognition site; other site 272123003565 dimerization interface [polypeptide binding]; other site 272123003566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123003567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272123003568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123003569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123003570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272123003571 putative substrate translocation pore; other site 272123003572 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123003573 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272123003574 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272123003575 acyl-CoA synthetase; Validated; Region: PRK05850 272123003576 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272123003577 acyl-activating enzyme (AAE) consensus motif; other site 272123003578 active site 272123003579 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123003580 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123003581 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272123003582 active site 272123003583 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123003584 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272123003585 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272123003586 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272123003587 putative NADP binding site [chemical binding]; other site 272123003588 active site 272123003589 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123003590 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272123003591 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123003592 active site 272123003593 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272123003594 Condensation domain; Region: Condensation; pfam00668 272123003595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123003596 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123003597 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272123003598 acyl-activating enzyme (AAE) consensus motif; other site 272123003599 AMP binding site [chemical binding]; other site 272123003600 Condensation domain; Region: Condensation; pfam00668 272123003601 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 272123003602 acyl carrier protein; Provisional; Region: acpP; PRK00982 272123003603 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272123003604 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272123003605 dimer interface [polypeptide binding]; other site 272123003606 active site 272123003607 ParB-like nuclease domain; Region: ParBc; pfam02195 272123003608 DDE superfamily endonuclease; Region: DDE_5; cl17874 272123003609 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123003610 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272123003611 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 272123003612 substrate binding pocket [chemical binding]; other site 272123003613 active site 272123003614 iron coordination sites [ion binding]; other site 272123003615 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123003616 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272123003617 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272123003618 N-terminal domain interface [polypeptide binding]; other site 272123003619 dimer interface [polypeptide binding]; other site 272123003620 substrate binding pocket (H-site) [chemical binding]; other site 272123003621 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 272123003622 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272123003623 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123003624 putative active site [active] 272123003625 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 272123003626 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272123003627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123003628 non-specific DNA binding site [nucleotide binding]; other site 272123003629 salt bridge; other site 272123003630 sequence-specific DNA binding site [nucleotide binding]; other site 272123003631 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 272123003632 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272123003633 active site 272123003634 non-prolyl cis peptide bond; other site 272123003635 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 272123003636 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272123003637 active site 272123003638 non-prolyl cis peptide bond; other site 272123003639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272123003640 Predicted esterase [General function prediction only]; Region: COG0400 272123003641 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123003642 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123003643 active site 272123003644 catalytic tetrad [active] 272123003645 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272123003646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123003647 substrate binding pocket [chemical binding]; other site 272123003648 membrane-bound complex binding site; other site 272123003649 hinge residues; other site 272123003650 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123003651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123003652 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 272123003653 Walker A/P-loop; other site 272123003654 ATP binding site [chemical binding]; other site 272123003655 Q-loop/lid; other site 272123003656 ABC transporter signature motif; other site 272123003657 Walker B; other site 272123003658 D-loop; other site 272123003659 H-loop/switch region; other site 272123003660 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272123003661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123003662 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123003663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123003664 non-specific DNA binding site [nucleotide binding]; other site 272123003665 salt bridge; other site 272123003666 sequence-specific DNA binding site [nucleotide binding]; other site 272123003667 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 272123003668 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 272123003669 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272123003670 active site 272123003671 substrate binding site [chemical binding]; other site 272123003672 Mg2+ binding site [ion binding]; other site 272123003673 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272123003674 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 272123003675 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123003676 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123003677 TniQ; Region: TniQ; pfam06527 272123003678 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123003679 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123003680 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272123003681 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272123003682 NAD binding site [chemical binding]; other site 272123003683 catalytic Zn binding site [ion binding]; other site 272123003684 structural Zn binding site [ion binding]; other site 272123003685 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 272123003686 putative hydrophobic ligand binding site [chemical binding]; other site 272123003687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123003688 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123003689 von Willebrand factor; Region: vWF_A; pfam12450 272123003690 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 272123003691 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 272123003692 metal ion-dependent adhesion site (MIDAS); other site 272123003693 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 272123003694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123003695 TPR motif; other site 272123003696 binding surface 272123003697 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123003698 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272123003699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123003700 ATP binding site [chemical binding]; other site 272123003701 putative Mg++ binding site [ion binding]; other site 272123003702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123003703 nucleotide binding region [chemical binding]; other site 272123003704 ATP-binding site [chemical binding]; other site 272123003705 GUN4-like; Region: GUN4; pfam05419 272123003706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272123003707 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272123003708 FMN binding site [chemical binding]; other site 272123003709 active site 272123003710 substrate binding site [chemical binding]; other site 272123003711 catalytic residue [active] 272123003712 Putative restriction endonuclease; Region: Uma2; pfam05685 272123003713 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272123003714 FAD binding site [chemical binding]; other site 272123003715 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272123003716 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272123003717 active site 272123003718 HIGH motif; other site 272123003719 dimer interface [polypeptide binding]; other site 272123003720 KMSKS motif; other site 272123003721 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272123003722 B12 binding domain; Region: B12-binding; pfam02310 272123003723 B12 binding site [chemical binding]; other site 272123003724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123003725 FeS/SAM binding site; other site 272123003726 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 272123003727 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 272123003728 hydrophobic ligand binding site; other site 272123003729 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123003730 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123003731 catalytic residues [active] 272123003732 catalytic nucleophile [active] 272123003733 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123003734 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123003735 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123003736 Synaptic Site I dimer interface [polypeptide binding]; other site 272123003737 DNA binding site [nucleotide binding] 272123003738 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123003739 DNA-binding interface [nucleotide binding]; DNA binding site 272123003740 Integrase core domain; Region: rve; pfam00665 272123003741 Integrase core domain; Region: rve_3; cl15866 272123003742 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123003743 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 272123003744 Predicted membrane protein [Function unknown]; Region: COG4244 272123003745 ABC1 family; Region: ABC1; cl17513 272123003746 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272123003747 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 272123003748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123003749 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123003750 BON domain; Region: BON; cl02771 272123003751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123003752 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 272123003753 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272123003754 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123003755 C-terminal domain interface [polypeptide binding]; other site 272123003756 GSH binding site (G-site) [chemical binding]; other site 272123003757 dimer interface [polypeptide binding]; other site 272123003758 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272123003759 N-terminal domain interface [polypeptide binding]; other site 272123003760 dimer interface [polypeptide binding]; other site 272123003761 substrate binding pocket (H-site) [chemical binding]; other site 272123003762 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 272123003763 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123003764 active site 272123003765 catalytic residues [active] 272123003766 DNA binding site [nucleotide binding] 272123003767 Int/Topo IB signature motif; other site 272123003768 UV-endonuclease UvdE; Region: UvdE; cl10036 272123003769 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 272123003770 KGK domain; Region: KGK; pfam08872 272123003771 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 272123003772 D5 N terminal like; Region: D5_N; smart00885 272123003773 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 272123003774 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272123003775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272123003776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123003777 dimerization interface [polypeptide binding]; other site 272123003778 putative DNA binding site [nucleotide binding]; other site 272123003779 putative Zn2+ binding site [ion binding]; other site 272123003780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272123003781 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272123003782 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272123003783 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272123003784 metal binding site [ion binding]; metal-binding site 272123003785 S-layer homology domain; Region: SLH; pfam00395 272123003786 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123003787 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272123003788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123003789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123003790 dimer interface [polypeptide binding]; other site 272123003791 phosphorylation site [posttranslational modification] 272123003792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272123003793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123003794 Coenzyme A binding pocket [chemical binding]; other site 272123003795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003796 putative active site [active] 272123003797 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272123003798 Protein export membrane protein; Region: SecD_SecF; pfam02355 272123003799 protein-export membrane protein SecD; Region: secD; TIGR01129 272123003800 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272123003801 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 272123003802 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272123003803 alpha subunit interface [polypeptide binding]; other site 272123003804 TPP binding site [chemical binding]; other site 272123003805 heterodimer interface [polypeptide binding]; other site 272123003806 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272123003807 PemK-like protein; Region: PemK; pfam02452 272123003808 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 272123003809 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 272123003810 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 272123003811 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123003812 GxxExxY protein; Region: GxxExxY; TIGR04256 272123003813 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 272123003814 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 272123003815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123003816 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272123003817 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272123003818 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 272123003819 pseudouridine synthase; Region: TIGR00093 272123003820 probable active site [active] 272123003821 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 272123003822 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 272123003823 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272123003824 active site 272123003825 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123003826 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123003827 phosphopeptide binding site; other site 272123003828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123003829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123003830 active site 272123003831 ATP binding site [chemical binding]; other site 272123003832 substrate binding site [chemical binding]; other site 272123003833 activation loop (A-loop); other site 272123003834 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003835 putative active site [active] 272123003836 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 272123003837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123003838 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272123003839 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123003840 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272123003841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123003842 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272123003843 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272123003844 inhibitor-cofactor binding pocket; inhibition site 272123003845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123003846 catalytic residue [active] 272123003847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123003849 NAD(P) binding site [chemical binding]; other site 272123003850 active site 272123003851 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 272123003852 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123003853 active site 272123003854 metal binding site [ion binding]; metal-binding site 272123003855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123003856 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123003857 NAD(P) binding site [chemical binding]; other site 272123003858 active site 272123003859 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 272123003860 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272123003861 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123003862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123003863 S-adenosylmethionine binding site [chemical binding]; other site 272123003864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123003865 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123003866 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 272123003867 putative trimer interface [polypeptide binding]; other site 272123003868 putative active site [active] 272123003869 putative substrate binding site [chemical binding]; other site 272123003870 putative CoA binding site [chemical binding]; other site 272123003871 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 272123003872 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 272123003873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123003874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123003875 S-adenosylmethionine binding site [chemical binding]; other site 272123003876 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272123003877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123003878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123003879 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 272123003880 catalytic residues [active] 272123003881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272123003882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123003883 dimer interface [polypeptide binding]; other site 272123003884 conserved gate region; other site 272123003885 ABC-ATPase subunit interface; other site 272123003886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272123003887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272123003888 nucleotide binding site [chemical binding]; other site 272123003889 CTP synthetase; Validated; Region: pyrG; PRK05380 272123003890 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272123003891 Catalytic site [active] 272123003892 active site 272123003893 UTP binding site [chemical binding]; other site 272123003894 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272123003895 active site 272123003896 putative oxyanion hole; other site 272123003897 catalytic triad [active] 272123003898 Bacterial SH3 domain; Region: SH3_3; pfam08239 272123003899 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123003900 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123003901 active site 272123003902 metal binding site [ion binding]; metal-binding site 272123003903 Bacterial SH3 domain; Region: SH3_3; pfam08239 272123003904 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123003905 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123003906 active site 272123003907 metal binding site [ion binding]; metal-binding site 272123003908 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 272123003909 S-formylglutathione hydrolase; Region: PLN02442 272123003910 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 272123003911 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003912 putative active site [active] 272123003913 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123003914 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272123003915 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272123003916 NAD(P) binding site [chemical binding]; other site 272123003917 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 272123003918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123003919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123003920 homodimer interface [polypeptide binding]; other site 272123003921 catalytic residue [active] 272123003922 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272123003923 RimM N-terminal domain; Region: RimM; pfam01782 272123003924 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003925 putative active site [active] 272123003926 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123003927 putative active site [active] 272123003928 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272123003929 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272123003930 glucokinase; Provisional; Region: glk; PRK00292 272123003931 glucokinase, proteobacterial type; Region: glk; TIGR00749 272123003932 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123003933 catalytic core [active] 272123003934 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 272123003935 CAS motifs; other site 272123003936 active site 272123003937 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 272123003938 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 272123003939 putative multimerization interface [polypeptide binding]; other site 272123003940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272123003941 dimerization interface [polypeptide binding]; other site 272123003942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 272123003943 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 272123003944 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272123003945 dimerization interface [polypeptide binding]; other site 272123003946 active site 272123003947 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123003948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123003949 active site 272123003950 phosphorylation site [posttranslational modification] 272123003951 intermolecular recognition site; other site 272123003952 dimerization interface [polypeptide binding]; other site 272123003953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123003954 DNA binding residues [nucleotide binding] 272123003955 dimerization interface [polypeptide binding]; other site 272123003956 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 272123003957 Double zinc ribbon; Region: DZR; pfam12773 272123003958 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272123003959 active site 272123003960 CHAT domain; Region: CHAT; cl17868 272123003961 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123003962 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123003963 phosphopeptide binding site; other site 272123003964 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123003965 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123003966 phosphopeptide binding site; other site 272123003967 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 272123003968 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 272123003969 Predicted membrane protein [Function unknown]; Region: COG3431 272123003970 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 272123003971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123003972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123003973 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 272123003974 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123003975 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123003976 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123003977 oligomeric interface; other site 272123003978 homodimer interface [polypeptide binding]; other site 272123003979 putative active site [active] 272123003980 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 272123003981 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272123003982 iron-sulfur cluster [ion binding]; other site 272123003983 [2Fe-2S] cluster binding site [ion binding]; other site 272123003984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272123003985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272123003986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272123003987 dimerization interface [polypeptide binding]; other site 272123003988 hypothetical protein; Provisional; Region: PRK07394 272123003989 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272123003990 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272123003991 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123003992 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272123003993 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 272123003994 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 272123003995 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 272123003996 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 272123003997 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 272123003998 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 272123003999 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 272123004000 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 272123004001 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 272123004002 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272123004003 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272123004004 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123004005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123004006 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 272123004007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123004008 WYL domain; Region: WYL; pfam13280 272123004009 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272123004010 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272123004011 tetramerization interface [polypeptide binding]; other site 272123004012 active site 272123004013 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272123004014 dimer interface [polypeptide binding]; other site 272123004015 substrate binding site [chemical binding]; other site 272123004016 metal binding sites [ion binding]; metal-binding site 272123004017 Bacterial sugar transferase; Region: Bac_transf; cl00939 272123004018 Uncharacterized conserved protein [Function unknown]; Region: COG2006 272123004019 Domain of unknown function (DUF362); Region: DUF362; pfam04015 272123004020 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123004021 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123004022 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 272123004023 Aspartase; Region: Aspartase; cd01357 272123004024 active sites [active] 272123004025 tetramer interface [polypeptide binding]; other site 272123004026 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272123004027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272123004028 active site 272123004029 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272123004030 protein binding site [polypeptide binding]; other site 272123004031 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272123004032 putative substrate binding region [chemical binding]; other site 272123004033 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272123004034 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272123004035 minor groove reading motif; other site 272123004036 helix-hairpin-helix signature motif; other site 272123004037 substrate binding pocket [chemical binding]; other site 272123004038 active site 272123004039 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272123004040 ribosomal protein S14; Region: rps14; CHL00074 272123004041 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272123004042 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 272123004043 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272123004044 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272123004045 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272123004046 active site 272123004047 catalytic residues [active] 272123004048 metal binding site [ion binding]; metal-binding site 272123004049 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272123004050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123004051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123004052 Coenzyme A binding pocket [chemical binding]; other site 272123004053 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272123004054 DHH family; Region: DHH; pfam01368 272123004055 DHHA1 domain; Region: DHHA1; pfam02272 272123004056 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272123004057 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272123004058 putative active site [active] 272123004059 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272123004060 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272123004061 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272123004062 protein binding site [polypeptide binding]; other site 272123004063 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272123004064 Catalytic dyad [active] 272123004065 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123004066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123004067 active site 272123004068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123004069 RNA binding surface [nucleotide binding]; other site 272123004070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272123004071 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272123004072 substrate binding site [chemical binding]; other site 272123004073 oxyanion hole (OAH) forming residues; other site 272123004074 trimer interface [polypeptide binding]; other site 272123004075 Protein of unknown function (DUF721); Region: DUF721; cl02324 272123004076 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272123004077 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272123004078 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123004079 catalytic residues [active] 272123004080 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 272123004081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123004082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123004083 homodimer interface [polypeptide binding]; other site 272123004084 catalytic residue [active] 272123004085 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272123004086 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272123004087 GIY-YIG motif/motif A; other site 272123004088 active site 272123004089 catalytic site [active] 272123004090 putative DNA binding site [nucleotide binding]; other site 272123004091 metal binding site [ion binding]; metal-binding site 272123004092 UvrB/uvrC motif; Region: UVR; pfam02151 272123004093 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272123004094 DNA polymerase II large subunit; Provisional; Region: PRK14714 272123004095 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 272123004096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123004097 FeS/SAM binding site; other site 272123004098 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 272123004099 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272123004100 active site 272123004101 SAM binding site [chemical binding]; other site 272123004102 homodimer interface [polypeptide binding]; other site 272123004103 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272123004104 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272123004105 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272123004106 active site 272123004107 (T/H)XGH motif; other site 272123004108 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272123004109 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 272123004110 putative active site [active] 272123004111 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123004112 oligomeric interface; other site 272123004113 putative active site [active] 272123004114 homodimer interface [polypeptide binding]; other site 272123004115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123004116 dimerization interface [polypeptide binding]; other site 272123004117 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123004118 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123004119 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272123004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123004121 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123004122 anti sigma factor interaction site; other site 272123004123 regulatory phosphorylation site [posttranslational modification]; other site 272123004124 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 272123004125 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123004126 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123004127 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123004128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123004129 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272123004130 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272123004131 active site 272123004132 HIGH motif; other site 272123004133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272123004134 KMSKS motif; other site 272123004135 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 272123004136 tRNA binding surface [nucleotide binding]; other site 272123004137 anticodon binding site; other site 272123004138 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272123004139 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123004140 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272123004141 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 272123004142 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 272123004143 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 272123004144 active site 272123004145 dimer interface [polypeptide binding]; other site 272123004146 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 272123004147 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272123004148 MPT binding site; other site 272123004149 trimer interface [polypeptide binding]; other site 272123004150 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272123004151 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 272123004152 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272123004153 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272123004154 Mg++ binding site [ion binding]; other site 272123004155 putative catalytic motif [active] 272123004156 putative substrate binding site [chemical binding]; other site 272123004157 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 272123004158 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 272123004159 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 272123004160 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 272123004161 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272123004162 DNA binding site [nucleotide binding] 272123004163 catalytic residue [active] 272123004164 H2TH interface [polypeptide binding]; other site 272123004165 putative catalytic residues [active] 272123004166 turnover-facilitating residue; other site 272123004167 intercalation triad [nucleotide binding]; other site 272123004168 8OG recognition residue [nucleotide binding]; other site 272123004169 putative reading head residues; other site 272123004170 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272123004171 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272123004172 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 272123004173 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272123004174 active site 272123004175 metal binding site [ion binding]; metal-binding site 272123004176 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123004177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272123004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123004179 dimer interface [polypeptide binding]; other site 272123004180 conserved gate region; other site 272123004181 putative PBP binding loops; other site 272123004182 ABC-ATPase subunit interface; other site 272123004183 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272123004184 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272123004185 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272123004186 dinuclear metal binding motif [ion binding]; other site 272123004187 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123004188 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123004189 ligand binding site [chemical binding]; other site 272123004190 flexible hinge region; other site 272123004191 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272123004192 putative switch regulator; other site 272123004193 non-specific DNA interactions [nucleotide binding]; other site 272123004194 DNA binding site [nucleotide binding] 272123004195 sequence specific DNA binding site [nucleotide binding]; other site 272123004196 putative cAMP binding site [chemical binding]; other site 272123004197 Predicted membrane protein [Function unknown]; Region: COG4241 272123004198 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272123004199 putative dimer interface [polypeptide binding]; other site 272123004200 active site pocket [active] 272123004201 putative cataytic base [active] 272123004202 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272123004203 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 272123004204 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 272123004205 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 272123004206 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 272123004207 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272123004208 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 272123004209 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 272123004210 NADP binding site [chemical binding]; other site 272123004211 active site 272123004212 putative substrate binding site [chemical binding]; other site 272123004213 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 272123004214 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 272123004215 NADP-binding site; other site 272123004216 homotetramer interface [polypeptide binding]; other site 272123004217 substrate binding site [chemical binding]; other site 272123004218 homodimer interface [polypeptide binding]; other site 272123004219 active site 272123004220 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272123004221 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 272123004222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123004223 putative ADP-binding pocket [chemical binding]; other site 272123004224 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123004225 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 272123004226 putative NAD(P) binding site [chemical binding]; other site 272123004227 active site 272123004228 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272123004229 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 272123004230 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272123004231 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272123004232 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272123004233 P-loop containing region of AAA domain; Region: AAA_29; cl17516 272123004234 AAA domain; Region: AAA_21; pfam13304 272123004235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123004236 ATP binding site [chemical binding]; other site 272123004237 Q-loop/lid; other site 272123004238 ABC transporter signature motif; other site 272123004239 Walker B; other site 272123004240 D-loop; other site 272123004241 H-loop/switch region; other site 272123004242 PPR repeat family; Region: PPR_2; pfam13041 272123004243 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123004244 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123004245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 272123004246 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123004247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123004248 active site 272123004249 ATP binding site [chemical binding]; other site 272123004250 substrate binding site [chemical binding]; other site 272123004251 activation loop (A-loop); other site 272123004252 GAF domain; Region: GAF; pfam01590 272123004253 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004254 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123004255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004257 dimer interface [polypeptide binding]; other site 272123004258 phosphorylation site [posttranslational modification] 272123004259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004260 ATP binding site [chemical binding]; other site 272123004261 Mg2+ binding site [ion binding]; other site 272123004262 G-X-G motif; other site 272123004263 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123004264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004265 active site 272123004266 phosphorylation site [posttranslational modification] 272123004267 intermolecular recognition site; other site 272123004268 dimerization interface [polypeptide binding]; other site 272123004269 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004271 active site 272123004272 phosphorylation site [posttranslational modification] 272123004273 intermolecular recognition site; other site 272123004274 dimerization interface [polypeptide binding]; other site 272123004275 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123004276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123004277 metal binding site [ion binding]; metal-binding site 272123004278 active site 272123004279 I-site; other site 272123004280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123004281 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004283 active site 272123004284 phosphorylation site [posttranslational modification] 272123004285 intermolecular recognition site; other site 272123004286 dimerization interface [polypeptide binding]; other site 272123004287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004289 ATP binding site [chemical binding]; other site 272123004290 Mg2+ binding site [ion binding]; other site 272123004291 G-X-G motif; other site 272123004292 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 272123004293 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 272123004294 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 272123004295 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 272123004296 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272123004297 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272123004298 catalytic residues [active] 272123004299 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272123004300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123004301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004302 active site 272123004303 phosphorylation site [posttranslational modification] 272123004304 intermolecular recognition site; other site 272123004305 dimerization interface [polypeptide binding]; other site 272123004306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123004307 DNA binding site [nucleotide binding] 272123004308 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004310 dimer interface [polypeptide binding]; other site 272123004311 phosphorylation site [posttranslational modification] 272123004312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004313 ATP binding site [chemical binding]; other site 272123004314 Mg2+ binding site [ion binding]; other site 272123004315 G-X-G motif; other site 272123004316 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272123004317 PhoU domain; Region: PhoU; pfam01895 272123004318 PhoU domain; Region: PhoU; pfam01895 272123004319 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123004320 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272123004321 S-layer homology domain; Region: SLH; pfam00395 272123004322 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123004323 S-layer homology domain; Region: SLH; pfam00395 272123004324 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123004325 S-layer homology domain; Region: SLH; pfam00395 272123004326 S-layer homology domain; Region: SLH; pfam00395 272123004327 S-layer homology domain; Region: SLH; pfam00395 272123004328 GAF domain; Region: GAF; cl17456 272123004329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004331 dimer interface [polypeptide binding]; other site 272123004332 phosphorylation site [posttranslational modification] 272123004333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004334 ATP binding site [chemical binding]; other site 272123004335 Mg2+ binding site [ion binding]; other site 272123004336 G-X-G motif; other site 272123004337 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 272123004338 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 272123004339 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 272123004340 seryl-tRNA synthetase; Provisional; Region: PRK05431 272123004341 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272123004342 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272123004343 dimer interface [polypeptide binding]; other site 272123004344 active site 272123004345 motif 1; other site 272123004346 motif 2; other site 272123004347 motif 3; other site 272123004348 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 272123004349 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 272123004350 putative active site [active] 272123004351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123004353 dimerization interface [polypeptide binding]; other site 272123004354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004355 dimer interface [polypeptide binding]; other site 272123004356 phosphorylation site [posttranslational modification] 272123004357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004358 ATP binding site [chemical binding]; other site 272123004359 Mg2+ binding site [ion binding]; other site 272123004360 G-X-G motif; other site 272123004361 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272123004362 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272123004363 putative ligand binding site [chemical binding]; other site 272123004364 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272123004365 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123004366 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272123004367 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272123004368 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272123004369 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123004370 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272123004371 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272123004372 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272123004373 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272123004374 substrate binding site [chemical binding]; other site 272123004375 hexamer interface [polypeptide binding]; other site 272123004376 metal binding site [ion binding]; metal-binding site 272123004377 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 272123004378 putative catalytic residues [active] 272123004379 putative active site [active] 272123004380 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272123004381 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004383 active site 272123004384 phosphorylation site [posttranslational modification] 272123004385 intermolecular recognition site; other site 272123004386 dimerization interface [polypeptide binding]; other site 272123004387 PAS domain; Region: PAS; smart00091 272123004388 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123004389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004390 dimer interface [polypeptide binding]; other site 272123004391 phosphorylation site [posttranslational modification] 272123004392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004393 ATP binding site [chemical binding]; other site 272123004394 Mg2+ binding site [ion binding]; other site 272123004395 G-X-G motif; other site 272123004396 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004398 active site 272123004399 phosphorylation site [posttranslational modification] 272123004400 intermolecular recognition site; other site 272123004401 dimerization interface [polypeptide binding]; other site 272123004402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123004403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004404 phosphorylation site [posttranslational modification] 272123004405 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004406 GAF domain; Region: GAF_3; pfam13492 272123004407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004408 dimer interface [polypeptide binding]; other site 272123004409 phosphorylation site [posttranslational modification] 272123004410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004411 ATP binding site [chemical binding]; other site 272123004412 Mg2+ binding site [ion binding]; other site 272123004413 G-X-G motif; other site 272123004414 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123004415 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123004416 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272123004417 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272123004418 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272123004419 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272123004420 active site 272123004421 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 272123004422 four helix bundle protein; Region: TIGR02436 272123004423 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272123004424 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272123004425 active site 272123004426 (T/H)XGH motif; other site 272123004427 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 272123004428 nudix motif; other site 272123004429 NAD synthetase; Provisional; Region: PRK13981 272123004430 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272123004431 multimer interface [polypeptide binding]; other site 272123004432 active site 272123004433 catalytic triad [active] 272123004434 protein interface 1 [polypeptide binding]; other site 272123004435 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272123004436 homodimer interface [polypeptide binding]; other site 272123004437 NAD binding pocket [chemical binding]; other site 272123004438 ATP binding pocket [chemical binding]; other site 272123004439 Mg binding site [ion binding]; other site 272123004440 active-site loop [active] 272123004441 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123004442 TPR repeat; Region: TPR_11; pfam13414 272123004443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123004444 binding surface 272123004445 TPR motif; other site 272123004446 TPR repeat; Region: TPR_11; pfam13414 272123004447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123004448 binding surface 272123004449 TPR motif; other site 272123004450 Uncharacterized conserved protein [Function unknown]; Region: COG0393 272123004451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123004452 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 272123004453 putative DNA binding site [nucleotide binding]; other site 272123004454 putative Zn2+ binding site [ion binding]; other site 272123004455 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272123004456 putative ABC transporter; Region: ycf24; CHL00085 272123004457 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 272123004458 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272123004459 Walker A/P-loop; other site 272123004460 ATP binding site [chemical binding]; other site 272123004461 Q-loop/lid; other site 272123004462 ABC transporter signature motif; other site 272123004463 Walker B; other site 272123004464 D-loop; other site 272123004465 H-loop/switch region; other site 272123004466 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272123004467 FeS assembly protein SufD; Region: sufD; TIGR01981 272123004468 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272123004469 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272123004470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123004471 catalytic residue [active] 272123004472 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272123004473 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 272123004474 P-loop, Walker A motif; other site 272123004475 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272123004476 Base recognition motif; other site 272123004477 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272123004478 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123004479 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123004480 structural tetrad; other site 272123004481 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272123004482 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272123004483 intersubunit interface [polypeptide binding]; other site 272123004484 Cytochrome P450; Region: p450; pfam00067 272123004485 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272123004486 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272123004487 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272123004488 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272123004489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123004490 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272123004491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123004492 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 272123004493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272123004494 Cytochrome P450; Region: p450; pfam00067 272123004495 glycogen synthase; Provisional; Region: glgA; PRK00654 272123004496 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272123004497 ADP-binding pocket [chemical binding]; other site 272123004498 homodimer interface [polypeptide binding]; other site 272123004499 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 272123004500 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 272123004501 TPP-binding site [chemical binding]; other site 272123004502 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 272123004503 Restriction endonuclease; Region: Mrr_cat; pfam04471 272123004504 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123004505 oligomeric interface; other site 272123004506 putative active site [active] 272123004507 homodimer interface [polypeptide binding]; other site 272123004508 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272123004509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123004510 motif II; other site 272123004511 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 272123004512 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 272123004513 dimer interface [polypeptide binding]; other site 272123004514 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 272123004515 active site 272123004516 Fe binding site [ion binding]; other site 272123004517 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272123004518 classical (c) SDRs; Region: SDR_c; cd05233 272123004519 NAD(P) binding site [chemical binding]; other site 272123004520 active site 272123004521 LabA_like proteins; Region: LabA_like/DUF88; cl10034 272123004522 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 272123004523 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 272123004524 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123004525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123004526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123004527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123004528 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 272123004529 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 272123004530 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123004531 putative active site [active] 272123004532 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272123004533 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272123004534 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272123004535 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272123004536 dimer interface [polypeptide binding]; other site 272123004537 catalytic triad [active] 272123004538 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 272123004539 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 272123004540 recombinase A; Provisional; Region: recA; PRK09354 272123004541 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272123004542 hexamer interface [polypeptide binding]; other site 272123004543 Walker A motif; other site 272123004544 ATP binding site [chemical binding]; other site 272123004545 Walker B motif; other site 272123004546 MFS/sugar transport protein; Region: MFS_2; pfam13347 272123004547 hypothetical protein; Validated; Region: PRK07411 272123004548 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272123004549 ATP binding site [chemical binding]; other site 272123004550 substrate interface [chemical binding]; other site 272123004551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272123004552 active site residue [active] 272123004553 LabA_like proteins; Region: LabA_like; cd06167 272123004554 putative metal binding site [ion binding]; other site 272123004555 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272123004556 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272123004557 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 272123004558 Phycobilisome protein; Region: Phycobilisome; cl08227 272123004559 Phycobilisome protein; Region: Phycobilisome; cl08227 272123004560 phycobillisome linker protein; Region: apcE; CHL00091 272123004561 Phycobilisome protein; Region: Phycobilisome; cl08227 272123004562 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004563 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004564 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004565 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004566 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123004567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123004568 S-adenosylmethionine binding site [chemical binding]; other site 272123004569 ATP synthase I chain; Region: ATP_synt_I; pfam03899 272123004570 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272123004571 ATP synthase CF0 A subunit; Region: atpI; CHL00046 272123004572 ATP synthase CF0 C subunit; Region: atpH; CHL00061 272123004573 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 272123004574 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 272123004575 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 272123004576 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272123004577 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 272123004578 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 272123004579 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272123004580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272123004581 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272123004582 beta subunit interaction interface [polypeptide binding]; other site 272123004583 Walker A motif; other site 272123004584 ATP binding site [chemical binding]; other site 272123004585 Walker B motif; other site 272123004586 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272123004587 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272123004588 core domain interface [polypeptide binding]; other site 272123004589 delta subunit interface [polypeptide binding]; other site 272123004590 epsilon subunit interface [polypeptide binding]; other site 272123004591 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123004592 oligomeric interface; other site 272123004593 putative active site [active] 272123004594 homodimer interface [polypeptide binding]; other site 272123004595 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123004596 putative active site [active] 272123004597 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 272123004598 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 272123004599 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123004600 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123004601 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 272123004602 Predicted flavoprotein [General function prediction only]; Region: COG0431 272123004603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272123004604 cell division protein; Validated; Region: ftsH; CHL00176 272123004605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123004606 Walker A motif; other site 272123004607 ATP binding site [chemical binding]; other site 272123004608 Walker B motif; other site 272123004609 arginine finger; other site 272123004610 Peptidase family M41; Region: Peptidase_M41; pfam01434 272123004611 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272123004612 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 272123004613 Cache domain; Region: Cache_1; pfam02743 272123004614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123004615 dimerization interface [polypeptide binding]; other site 272123004616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123004617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123004618 metal binding site [ion binding]; metal-binding site 272123004619 active site 272123004620 I-site; other site 272123004621 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123004622 active site 272123004623 catalytic residues [active] 272123004624 DNA binding site [nucleotide binding] 272123004625 Int/Topo IB signature motif; other site 272123004626 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 272123004627 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 272123004628 dimerization interface [polypeptide binding]; other site 272123004629 mannose binding site [chemical binding]; other site 272123004630 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123004631 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272123004632 RNA binding site [nucleotide binding]; other site 272123004633 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 272123004634 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 272123004635 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 272123004636 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 272123004637 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 272123004638 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272123004639 active site 272123004640 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 272123004641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123004642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123004643 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 272123004644 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 272123004645 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 272123004646 hydrogenase 2 large subunit; Provisional; Region: PRK10467 272123004647 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 272123004648 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272123004649 NifU-like domain; Region: NifU; cl00484 272123004650 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 272123004651 iron-sulfur cluster [ion binding]; other site 272123004652 [2Fe-2S] cluster binding site [ion binding]; other site 272123004653 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272123004654 Acylphosphatase; Region: Acylphosphatase; pfam00708 272123004655 HypF finger; Region: zf-HYPF; pfam07503 272123004656 HypF finger; Region: zf-HYPF; pfam07503 272123004657 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272123004658 HupF/HypC family; Region: HupF_HypC; pfam01455 272123004659 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 272123004660 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 272123004661 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 272123004662 active site 1 [active] 272123004663 dimer interface [polypeptide binding]; other site 272123004664 hexamer interface [polypeptide binding]; other site 272123004665 active site 2 [active] 272123004666 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 272123004667 dimerization interface [polypeptide binding]; other site 272123004668 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 272123004669 ATP binding site [chemical binding]; other site 272123004670 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 272123004671 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123004672 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 272123004673 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 272123004674 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272123004675 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272123004676 Moco binding site; other site 272123004677 metal coordination site [ion binding]; other site 272123004678 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 272123004679 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272123004680 active site 272123004681 dimer interface [polypeptide binding]; other site 272123004682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123004683 active site 272123004684 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272123004685 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 272123004686 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272123004687 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272123004688 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272123004689 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123004690 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272123004691 Lumazine binding domain; Region: Lum_binding; pfam00677 272123004692 Lumazine binding domain; Region: Lum_binding; pfam00677 272123004693 Bifunctional nuclease; Region: DNase-RNase; pfam02577 272123004694 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 272123004695 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123004696 active site 272123004697 catalytic tetrad [active] 272123004698 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272123004699 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272123004700 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272123004701 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272123004702 catalytic motif [active] 272123004703 Catalytic residue [active] 272123004704 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272123004705 ribosomal protein L21; Region: rpl21; CHL00075 272123004706 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 272123004707 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 272123004708 proton extrusion protein PcxA; Provisional; Region: PRK02507 272123004709 MltA specific insert domain; Region: MltA; cl08398 272123004710 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123004711 putative active site [active] 272123004712 tellurite resistance protein terB; Region: terB; cd07176 272123004713 putative metal binding site [ion binding]; other site 272123004714 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 272123004715 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272123004716 PYR/PP interface [polypeptide binding]; other site 272123004717 dimer interface [polypeptide binding]; other site 272123004718 TPP binding site [chemical binding]; other site 272123004719 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272123004720 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272123004721 TPP-binding site [chemical binding]; other site 272123004722 dimer interface [polypeptide binding]; other site 272123004723 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272123004724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123004725 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123004726 putative substrate translocation pore; other site 272123004727 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 272123004728 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 272123004729 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272123004730 C-terminal domain interface [polypeptide binding]; other site 272123004731 active site 272123004732 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272123004733 active site 272123004734 N-terminal domain interface [polypeptide binding]; other site 272123004735 CsbD-like; Region: CsbD; pfam05532 272123004736 YGGT family; Region: YGGT; pfam02325 272123004737 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123004738 active site 272123004739 carotene isomerase; Region: carot_isom; TIGR02730 272123004740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123004741 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272123004742 AMIN domain; Region: AMIN; pfam11741 272123004743 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272123004744 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272123004745 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 272123004746 ATP-grasp domain; Region: ATP-grasp; pfam02222 272123004747 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272123004748 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123004749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123004750 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272123004751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123004752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272123004753 Walker A/P-loop; other site 272123004754 ATP binding site [chemical binding]; other site 272123004755 Q-loop/lid; other site 272123004756 ABC transporter signature motif; other site 272123004757 Walker B; other site 272123004758 D-loop; other site 272123004759 H-loop/switch region; other site 272123004760 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272123004761 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272123004762 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272123004763 tartrate dehydrogenase; Region: TTC; TIGR02089 272123004764 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272123004765 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272123004766 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272123004767 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272123004768 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272123004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123004770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272123004771 putative substrate translocation pore; other site 272123004772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272123004773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272123004774 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272123004775 putative active site [active] 272123004776 homotetrameric interface [polypeptide binding]; other site 272123004777 metal binding site [ion binding]; metal-binding site 272123004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123004779 dimer interface [polypeptide binding]; other site 272123004780 conserved gate region; other site 272123004781 putative PBP binding loops; other site 272123004782 ABC-ATPase subunit interface; other site 272123004783 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272123004784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272123004785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123004786 dimer interface [polypeptide binding]; other site 272123004787 conserved gate region; other site 272123004788 putative PBP binding loops; other site 272123004789 ABC-ATPase subunit interface; other site 272123004790 cytochrome c-550; Provisional; Region: psbV; cl17239 272123004791 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 272123004792 plastocyanin; Provisional; Region: PRK02710 272123004793 Cytochrome c; Region: Cytochrom_C; cl11414 272123004794 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272123004795 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 272123004796 heme bH binding site [chemical binding]; other site 272123004797 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272123004798 intrachain domain interface; other site 272123004799 heme bL binding site [chemical binding]; other site 272123004800 interchain domain interface [polypeptide binding]; other site 272123004801 Qo binding site; other site 272123004802 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272123004803 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272123004804 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272123004805 TrkA-N domain; Region: TrkA_N; pfam02254 272123004806 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272123004807 ABC1 family; Region: ABC1; cl17513 272123004808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004809 GAF domain; Region: GAF; pfam01590 272123004810 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004811 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123004812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004814 dimer interface [polypeptide binding]; other site 272123004815 phosphorylation site [posttranslational modification] 272123004816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004817 ATP binding site [chemical binding]; other site 272123004818 Mg2+ binding site [ion binding]; other site 272123004819 G-X-G motif; other site 272123004820 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272123004821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123004822 Walker A motif; other site 272123004823 ATP binding site [chemical binding]; other site 272123004824 Walker B motif; other site 272123004825 arginine finger; other site 272123004826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004827 active site 272123004828 phosphorylation site [posttranslational modification] 272123004829 intermolecular recognition site; other site 272123004830 dimerization interface [polypeptide binding]; other site 272123004831 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004833 active site 272123004834 phosphorylation site [posttranslational modification] 272123004835 intermolecular recognition site; other site 272123004836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123004837 dimerization interface [polypeptide binding]; other site 272123004838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004839 dimer interface [polypeptide binding]; other site 272123004840 phosphorylation site [posttranslational modification] 272123004841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004842 ATP binding site [chemical binding]; other site 272123004843 Mg2+ binding site [ion binding]; other site 272123004844 G-X-G motif; other site 272123004845 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123004846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004847 active site 272123004848 phosphorylation site [posttranslational modification] 272123004849 intermolecular recognition site; other site 272123004850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123004851 dimer interface [polypeptide binding]; other site 272123004852 phosphorylation site [posttranslational modification] 272123004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123004854 ATP binding site [chemical binding]; other site 272123004855 Mg2+ binding site [ion binding]; other site 272123004856 G-X-G motif; other site 272123004857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123004858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004859 active site 272123004860 phosphorylation site [posttranslational modification] 272123004861 intermolecular recognition site; other site 272123004862 dimerization interface [polypeptide binding]; other site 272123004863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123004864 DNA binding residues [nucleotide binding] 272123004865 dimerization interface [polypeptide binding]; other site 272123004866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 272123004867 conserved hypothetical protein; Region: TIGR03492 272123004868 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123004869 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272123004870 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123004871 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 272123004872 DNA polymerase III subunit delta; Validated; Region: PRK07452 272123004873 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272123004874 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 272123004875 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 272123004876 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 272123004877 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 272123004878 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 272123004879 active site 272123004880 catalytic site [active] 272123004881 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 272123004882 calcium/proton exchanger (cax); Region: cax; TIGR00378 272123004883 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272123004884 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272123004885 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123004886 sucrose synthase; Region: sucr_synth; TIGR02470 272123004887 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272123004888 putative ADP-binding pocket [chemical binding]; other site 272123004889 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 272123004890 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123004891 active site 272123004892 ATP binding site [chemical binding]; other site 272123004893 substrate binding site [chemical binding]; other site 272123004894 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272123004895 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123004896 activation loop (A-loop); other site 272123004897 GUN4-like; Region: GUN4; pfam05419 272123004898 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272123004899 active site 272123004900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123004901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123004902 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 272123004903 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 272123004904 putative active site [active] 272123004905 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 272123004906 putative active site [active] 272123004907 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272123004908 active site 272123004909 SAM binding site [chemical binding]; other site 272123004910 homodimer interface [polypeptide binding]; other site 272123004911 Response regulator receiver domain; Region: Response_reg; pfam00072 272123004912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123004913 active site 272123004914 phosphorylation site [posttranslational modification] 272123004915 intermolecular recognition site; other site 272123004916 dimerization interface [polypeptide binding]; other site 272123004917 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272123004918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123004919 RNA binding surface [nucleotide binding]; other site 272123004920 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272123004921 active site 272123004922 Phycobilisome protein; Region: Phycobilisome; cl08227 272123004923 phycocyanin alpha subunit; Reviewed; Region: cpcA; CHL00170 272123004924 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004925 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 272123004926 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 272123004927 HEAT repeats; Region: HEAT_2; pfam13646 272123004928 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272123004929 HEAT repeats; Region: HEAT_2; pfam13646 272123004930 HEAT repeats; Region: HEAT_2; pfam13646 272123004931 HEAT repeats; Region: HEAT_2; pfam13646 272123004932 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004933 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004934 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123004935 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272123004936 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272123004937 Ligand Binding Site [chemical binding]; other site 272123004938 Molecular Tunnel; other site 272123004939 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272123004940 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 272123004941 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272123004942 catalytic residue [active] 272123004943 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272123004944 active site 272123004945 metal binding site [ion binding]; metal-binding site 272123004946 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 272123004947 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004948 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004949 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004950 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004951 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004952 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004953 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004954 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004955 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004956 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004957 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004958 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004959 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004960 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004961 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004962 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004963 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004964 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004965 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004966 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 272123004967 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123004968 Ca2+ binding site [ion binding]; other site 272123004969 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123004970 Ca2+ binding site [ion binding]; other site 272123004971 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123004972 Ca2+ binding site [ion binding]; other site 272123004973 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123004974 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272123004975 active site 272123004976 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272123004977 Ligand Binding Site [chemical binding]; other site 272123004978 Molecular Tunnel; other site 272123004979 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272123004980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272123004981 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272123004982 putative acyl-acceptor binding pocket; other site 272123004983 Protein of unknown function (DUF938); Region: DUF938; pfam06080 272123004984 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 272123004985 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272123004986 active site residue [active] 272123004987 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272123004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123004989 S-adenosylmethionine binding site [chemical binding]; other site 272123004990 phosphoribulokinase; Provisional; Region: PRK07429 272123004991 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 272123004992 active site 272123004993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 272123004994 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004995 GAF domain; Region: GAF; pfam01590 272123004996 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004997 Phytochrome region; Region: PHY; pfam00360 272123004998 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123004999 GAF domain; Region: GAF; pfam01590 272123005000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123005001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123005002 ATP binding site [chemical binding]; other site 272123005003 Mg2+ binding site [ion binding]; other site 272123005004 G-X-G motif; other site 272123005005 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 272123005006 MltA specific insert domain; Region: MltA; pfam03562 272123005007 3D domain; Region: 3D; pfam06725 272123005008 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 272123005009 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272123005010 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272123005011 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272123005012 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272123005013 active site 272123005014 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 272123005015 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272123005016 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 272123005017 dimer interface [polypeptide binding]; other site 272123005018 active site 272123005019 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272123005020 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272123005021 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272123005022 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272123005023 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 272123005024 active site 272123005025 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272123005026 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272123005027 NAD binding site [chemical binding]; other site 272123005028 homodimer interface [polypeptide binding]; other site 272123005029 active site 272123005030 substrate binding site [chemical binding]; other site 272123005031 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 272123005032 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272123005033 NADP binding site [chemical binding]; other site 272123005034 active site 272123005035 putative substrate binding site [chemical binding]; other site 272123005036 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272123005037 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 272123005038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123005039 putative homodimer interface [polypeptide binding]; other site 272123005040 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272123005041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123005042 UDP-galactopyranose mutase; Region: GLF; pfam03275 272123005043 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272123005044 catalytic motif [active] 272123005045 Catalytic residue [active] 272123005046 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272123005047 PHP domain; Region: PHP; pfam02811 272123005048 active site 272123005049 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272123005050 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272123005051 dimerization interface [polypeptide binding]; other site 272123005052 putative ATP binding site [chemical binding]; other site 272123005053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123005054 dimerization interface [polypeptide binding]; other site 272123005055 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123005056 cyclase homology domain; Region: CHD; cd07302 272123005057 nucleotidyl binding site; other site 272123005058 metal binding site [ion binding]; metal-binding site 272123005059 dimer interface [polypeptide binding]; other site 272123005060 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272123005061 metal coordination site [ion binding]; other site 272123005062 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272123005063 Moco binding site; other site 272123005064 metal coordination site [ion binding]; other site 272123005065 Proline dehydrogenase; Region: Pro_dh; pfam01619 272123005066 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 272123005067 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 272123005068 Glutamate binding site [chemical binding]; other site 272123005069 homodimer interface [polypeptide binding]; other site 272123005070 NAD binding site [chemical binding]; other site 272123005071 catalytic residues [active] 272123005072 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 272123005073 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 272123005074 Response regulator receiver domain; Region: Response_reg; pfam00072 272123005075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123005076 active site 272123005077 phosphorylation site [posttranslational modification] 272123005078 intermolecular recognition site; other site 272123005079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123005080 dimerization interface [polypeptide binding]; other site 272123005081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123005082 dimer interface [polypeptide binding]; other site 272123005083 phosphorylation site [posttranslational modification] 272123005084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123005085 ATP binding site [chemical binding]; other site 272123005086 Mg2+ binding site [ion binding]; other site 272123005087 G-X-G motif; other site 272123005088 Cache domain; Region: Cache_1; pfam02743 272123005089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123005090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123005091 dimer interface [polypeptide binding]; other site 272123005092 phosphorylation site [posttranslational modification] 272123005093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123005094 ATP binding site [chemical binding]; other site 272123005095 Mg2+ binding site [ion binding]; other site 272123005096 G-X-G motif; other site 272123005097 Response regulator receiver domain; Region: Response_reg; pfam00072 272123005098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123005099 active site 272123005100 phosphorylation site [posttranslational modification] 272123005101 intermolecular recognition site; other site 272123005102 dimerization interface [polypeptide binding]; other site 272123005103 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272123005104 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272123005105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123005106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123005107 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272123005108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272123005109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272123005110 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272123005111 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 272123005112 active site 272123005113 Zn binding site [ion binding]; other site 272123005114 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 272123005115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123005116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005117 Walker A/P-loop; other site 272123005118 ATP binding site [chemical binding]; other site 272123005119 Q-loop/lid; other site 272123005120 ABC transporter signature motif; other site 272123005121 Walker B; other site 272123005122 D-loop; other site 272123005123 H-loop/switch region; other site 272123005124 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123005125 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 272123005126 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123005127 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123005128 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 272123005129 ligand binding site [chemical binding]; other site 272123005130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123005131 ligand binding site [chemical binding]; other site 272123005132 flexible hinge region; other site 272123005133 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 272123005134 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 272123005135 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 272123005136 putative active site [active] 272123005137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123005138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005139 Walker A/P-loop; other site 272123005140 ATP binding site [chemical binding]; other site 272123005141 Q-loop/lid; other site 272123005142 ABC transporter signature motif; other site 272123005143 Walker B; other site 272123005144 D-loop; other site 272123005145 H-loop/switch region; other site 272123005146 DNA gyrase subunit A; Validated; Region: PRK05560 272123005147 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272123005148 CAP-like domain; other site 272123005149 active site 272123005150 primary dimer interface [polypeptide binding]; other site 272123005151 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005152 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005153 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005154 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005155 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005156 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123005157 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272123005158 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272123005159 putative active site [active] 272123005160 catalytic triad [active] 272123005161 putative dimer interface [polypeptide binding]; other site 272123005162 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 272123005163 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 272123005164 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 272123005165 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 272123005166 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 272123005167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123005168 Helix-turn-helix domain; Region: HTH_18; pfam12833 272123005169 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272123005170 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272123005171 DNA binding site [nucleotide binding] 272123005172 active site 272123005173 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123005174 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123005175 active site 272123005176 ATP binding site [chemical binding]; other site 272123005177 substrate binding site [chemical binding]; other site 272123005178 activation loop (A-loop); other site 272123005179 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123005180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123005181 active site 272123005182 ATP binding site [chemical binding]; other site 272123005183 substrate binding site [chemical binding]; other site 272123005184 activation loop (A-loop); other site 272123005185 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272123005186 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272123005187 Leucine rich repeat variant; Region: LRV; pfam01816 272123005188 Rubredoxin [Energy production and conversion]; Region: COG1773 272123005189 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272123005190 iron binding site [ion binding]; other site 272123005191 Ycf48-like protein; Provisional; Region: PRK13684 272123005192 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 272123005193 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 272123005194 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 272123005195 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 272123005196 photosystem II reaction center protein J; Provisional; Region: PRK02565 272123005197 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123005198 GAF domain; Region: GAF; pfam01590 272123005199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123005200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123005201 ATP binding site [chemical binding]; other site 272123005202 Mg2+ binding site [ion binding]; other site 272123005203 G-X-G motif; other site 272123005204 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123005205 HSP70 interaction site [polypeptide binding]; other site 272123005206 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123005207 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005208 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005210 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123005211 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 272123005212 putative NAD(P) binding site [chemical binding]; other site 272123005213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123005214 Domain of unknown function (DUF897); Region: DUF897; pfam05982 272123005215 Nitrogen regulatory protein P-II; Region: P-II; cl00412 272123005216 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 272123005217 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272123005218 dimer interface [polypeptide binding]; other site 272123005219 active site 272123005220 metal binding site [ion binding]; metal-binding site 272123005221 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005222 putative active site [active] 272123005223 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272123005224 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272123005225 Glucose inhibited division protein A; Region: GIDA; pfam01134 272123005226 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272123005227 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123005228 HEAT repeats; Region: HEAT_2; pfam13646 272123005229 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 272123005230 HEAT repeats; Region: HEAT_2; pfam13646 272123005231 protein binding surface [polypeptide binding]; other site 272123005232 HEAT repeats; Region: HEAT_2; pfam13646 272123005233 HEAT repeats; Region: HEAT_2; pfam13646 272123005234 HEAT repeats; Region: HEAT_2; pfam13646 272123005235 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 272123005236 protein binding surface [polypeptide binding]; other site 272123005237 HEAT repeats; Region: HEAT_2; pfam13646 272123005238 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 272123005239 HEAT repeats; Region: HEAT_2; pfam13646 272123005240 protein binding surface [polypeptide binding]; other site 272123005241 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 272123005242 HEAT repeats; Region: HEAT_2; pfam13646 272123005243 protein binding surface [polypeptide binding]; other site 272123005244 HEAT repeats; Region: HEAT_2; pfam13646 272123005245 GAF domain; Region: GAF; cl17456 272123005246 short chain dehydrogenase; Provisional; Region: PRK06197 272123005247 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 272123005248 putative NAD(P) binding site [chemical binding]; other site 272123005249 active site 272123005250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123005251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123005252 NACHT domain; Region: NACHT; pfam05729 272123005253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005254 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123005255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005257 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272123005258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123005259 motif II; other site 272123005260 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272123005261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123005262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123005263 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272123005264 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272123005265 Predicted transcriptional regulators [Transcription]; Region: COG1733 272123005266 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272123005267 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272123005268 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 272123005269 NADP binding site [chemical binding]; other site 272123005270 ChaB; Region: ChaB; cl01887 272123005271 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 272123005272 PLD-like domain; Region: PLDc_2; pfam13091 272123005273 putative active site [active] 272123005274 catalytic site [active] 272123005275 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 272123005276 PLD-like domain; Region: PLDc_2; pfam13091 272123005277 putative active site [active] 272123005278 catalytic site [active] 272123005279 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272123005280 Helix-hairpin-helix motif; Region: HHH; pfam00633 272123005281 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272123005282 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272123005283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123005284 catalytic residue [active] 272123005285 Predicted membrane protein [Function unknown]; Region: COG3431 272123005286 TPR repeat; Region: TPR_11; pfam13414 272123005287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005288 binding surface 272123005289 TPR motif; other site 272123005290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005291 binding surface 272123005292 TPR repeat; Region: TPR_11; pfam13414 272123005293 TPR motif; other site 272123005294 TPR repeat; Region: TPR_11; pfam13414 272123005295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005296 binding surface 272123005297 TPR motif; other site 272123005298 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123005299 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 272123005300 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 272123005301 C-terminal peptidase (prc); Region: prc; TIGR00225 272123005302 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272123005303 protein binding site [polypeptide binding]; other site 272123005304 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272123005305 Catalytic dyad [active] 272123005306 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123005307 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123005308 PAS domain S-box; Region: sensory_box; TIGR00229 272123005309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123005310 putative active site [active] 272123005311 heme pocket [chemical binding]; other site 272123005312 PAS domain; Region: PAS; smart00091 272123005313 PAS domain; Region: PAS_9; pfam13426 272123005314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123005315 putative active site [active] 272123005316 heme pocket [chemical binding]; other site 272123005317 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123005318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123005319 putative active site [active] 272123005320 heme pocket [chemical binding]; other site 272123005321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123005322 dimer interface [polypeptide binding]; other site 272123005323 phosphorylation site [posttranslational modification] 272123005324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123005325 ATP binding site [chemical binding]; other site 272123005326 Mg2+ binding site [ion binding]; other site 272123005327 G-X-G motif; other site 272123005328 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123005329 HEAT repeats; Region: HEAT_2; pfam13646 272123005330 HEAT repeats; Region: HEAT_2; pfam13646 272123005331 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 272123005332 HEAT repeats; Region: HEAT_2; pfam13646 272123005333 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 272123005334 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 272123005335 Phycobilisome protein; Region: Phycobilisome; cl08227 272123005336 Phycobilisome protein; Region: Phycobilisome; cl08227 272123005337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123005338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123005339 active site 272123005340 phosphorylation site [posttranslational modification] 272123005341 intermolecular recognition site; other site 272123005342 dimerization interface [polypeptide binding]; other site 272123005343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123005344 DNA binding site [nucleotide binding] 272123005345 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272123005346 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272123005347 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272123005348 CHAT domain; Region: CHAT; pfam12770 272123005349 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123005350 TPR repeat; Region: TPR_11; pfam13414 272123005351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005352 binding surface 272123005353 TPR motif; other site 272123005354 TPR repeat; Region: TPR_11; pfam13414 272123005355 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272123005356 catalytic triad [active] 272123005357 conserved cis-peptide bond; other site 272123005358 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272123005359 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272123005360 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123005361 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 272123005362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272123005363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272123005364 protein binding site [polypeptide binding]; other site 272123005365 Protein of unknown function (DUF760); Region: DUF760; pfam05542 272123005366 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 272123005367 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272123005368 substrate binding site; other site 272123005369 dimer interface; other site 272123005370 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 272123005371 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123005372 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 272123005373 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 272123005374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272123005375 metal binding site 2 [ion binding]; metal-binding site 272123005376 putative DNA binding helix; other site 272123005377 metal binding site 1 [ion binding]; metal-binding site 272123005378 dimer interface [polypeptide binding]; other site 272123005379 structural Zn2+ binding site [ion binding]; other site 272123005380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123005381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123005382 active site 272123005383 dimerization interface [polypeptide binding]; other site 272123005384 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 272123005385 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 272123005386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123005387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123005388 Coenzyme A binding pocket [chemical binding]; other site 272123005389 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272123005390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272123005391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123005392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272123005393 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 272123005394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123005395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123005396 homodimer interface [polypeptide binding]; other site 272123005397 catalytic residue [active] 272123005398 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272123005399 IHF dimer interface [polypeptide binding]; other site 272123005400 IHF - DNA interface [nucleotide binding]; other site 272123005401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 272123005402 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272123005403 AMIN domain; Region: AMIN; pfam11741 272123005404 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 272123005405 Secretin and TonB N terminus short domain; Region: STN; pfam07660 272123005406 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272123005407 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 272123005408 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 272123005409 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 272123005410 Cell division protein FtsA; Region: FtsA; cl17206 272123005411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272123005412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272123005413 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272123005414 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123005415 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123005416 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 272123005417 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272123005418 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272123005419 trimer interface [polypeptide binding]; other site 272123005420 putative metal binding site [ion binding]; other site 272123005421 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 272123005422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123005423 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272123005424 active site 272123005425 metal binding site [ion binding]; metal-binding site 272123005426 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123005427 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123005428 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123005429 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123005430 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123005431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123005432 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 272123005433 methionine aminopeptidase; Provisional; Region: PRK12318 272123005434 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272123005435 active site 272123005436 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272123005437 Amidase; Region: Amidase; pfam01425 272123005438 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123005439 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123005440 ligand binding site [chemical binding]; other site 272123005441 flexible hinge region; other site 272123005442 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272123005443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123005444 S-adenosylmethionine binding site [chemical binding]; other site 272123005445 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123005446 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005447 putative active site [active] 272123005448 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123005449 oligomeric interface; other site 272123005450 putative active site [active] 272123005451 homodimer interface [polypeptide binding]; other site 272123005452 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272123005453 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272123005454 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272123005455 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272123005456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123005457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123005458 Transposase IS200 like; Region: Y1_Tnp; cl00848 272123005459 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123005460 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005461 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005462 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005463 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005464 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005465 putative active site [active] 272123005466 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272123005467 FAD binding domain; Region: FAD_binding_4; pfam01565 272123005468 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272123005469 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 272123005470 Cysteine-rich domain; Region: CCG; pfam02754 272123005471 Cysteine-rich domain; Region: CCG; pfam02754 272123005472 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272123005473 propionate/acetate kinase; Provisional; Region: PRK12379 272123005474 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272123005475 homodimer interface [polypeptide binding]; other site 272123005476 substrate-cofactor binding pocket; other site 272123005477 Aminotransferase class IV; Region: Aminotran_4; pfam01063 272123005478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123005479 catalytic residue [active] 272123005480 FtsH Extracellular; Region: FtsH_ext; pfam06480 272123005481 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272123005482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123005483 Walker A motif; other site 272123005484 ATP binding site [chemical binding]; other site 272123005485 Walker B motif; other site 272123005486 arginine finger; other site 272123005487 Peptidase family M41; Region: Peptidase_M41; pfam01434 272123005488 Protein of unknown function DUF262; Region: DUF262; pfam03235 272123005489 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272123005490 Divergent AAA domain; Region: AAA_4; pfam04326 272123005491 PIN domain; Region: PIN; pfam01850 272123005492 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005493 putative active site [active] 272123005494 Lamin Tail Domain; Region: LTD; pfam00932 272123005495 Lamin Tail Domain; Region: LTD; pfam00932 272123005496 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 272123005497 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 272123005498 generic binding surface I; other site 272123005499 generic binding surface II; other site 272123005500 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 272123005501 putative active site [active] 272123005502 putative catalytic site [active] 272123005503 putative Mg binding site IVb [ion binding]; other site 272123005504 putative phosphate binding site [ion binding]; other site 272123005505 putative DNA binding site [nucleotide binding]; other site 272123005506 putative Mg binding site IVa [ion binding]; other site 272123005507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272123005508 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 272123005509 putative NAD(P) binding site [chemical binding]; other site 272123005510 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 272123005511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123005512 FeS/SAM binding site; other site 272123005513 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 272123005514 4Fe-4S binding domain; Region: Fer4; cl02805 272123005515 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272123005516 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272123005517 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272123005518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123005519 catalytic residue [active] 272123005520 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 272123005521 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272123005522 trimerization site [polypeptide binding]; other site 272123005523 active site 272123005524 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272123005525 NifU-like domain; Region: NifU; pfam01106 272123005526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123005527 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123005528 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 272123005529 inhibitor binding site; inhibition site 272123005530 catalytic motif [active] 272123005531 Catalytic residue [active] 272123005532 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123005533 active site 272123005534 catalytic residues [active] 272123005535 DNA binding site [nucleotide binding] 272123005536 Int/Topo IB signature motif; other site 272123005537 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272123005538 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272123005539 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123005540 active site 272123005541 catalytic residues [active] 272123005542 DNA binding site [nucleotide binding] 272123005543 Int/Topo IB signature motif; other site 272123005544 D5 N terminal like; Region: D5_N; cl07360 272123005545 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 272123005546 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123005547 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123005548 catalytic residues [active] 272123005549 catalytic nucleophile [active] 272123005550 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123005551 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123005552 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123005553 Synaptic Site I dimer interface [polypeptide binding]; other site 272123005554 DNA binding site [nucleotide binding] 272123005555 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123005556 DNA-binding interface [nucleotide binding]; DNA binding site 272123005557 Integrase core domain; Region: rve; pfam00665 272123005558 Integrase core domain; Region: rve_3; cl15866 272123005559 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123005560 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272123005561 Mg binding site [ion binding]; other site 272123005562 nucleotide binding site [chemical binding]; other site 272123005563 putative protofilament interface [polypeptide binding]; other site 272123005564 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 272123005565 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 272123005566 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272123005567 PIN domain; Region: PIN_3; cl17397 272123005568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272123005569 RNA replicase, beta subunit; Region: rep; PHA00028 272123005570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123005571 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272123005572 active site 272123005573 DNA binding site [nucleotide binding] 272123005574 Int/Topo IB signature motif; other site 272123005575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123005576 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 272123005577 Probable transposase; Region: OrfB_IS605; pfam01385 272123005578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123005579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123005580 non-specific DNA binding site [nucleotide binding]; other site 272123005581 salt bridge; other site 272123005582 sequence-specific DNA binding site [nucleotide binding]; other site 272123005583 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272123005584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123005585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123005586 P-loop; other site 272123005587 Magnesium ion binding site [ion binding]; other site 272123005588 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123005589 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123005590 Integrase core domain; Region: rve; pfam00665 272123005591 Integrase core domain; Region: rve_3; cl15866 272123005592 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123005593 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123005594 catalytic residues [active] 272123005595 catalytic nucleophile [active] 272123005596 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123005597 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123005598 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123005599 Synaptic Site I dimer interface [polypeptide binding]; other site 272123005600 DNA binding site [nucleotide binding] 272123005601 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123005602 DNA-binding interface [nucleotide binding]; DNA binding site 272123005603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123005604 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272123005605 putative addiction module antidote; Region: doc_partner; TIGR02609 272123005606 von Willebrand factor type D domain; Region: VWD; pfam00094 272123005607 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272123005608 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272123005609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123005610 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123005611 ParA-like protein; Provisional; Region: PHA02518 272123005612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123005613 P-loop; other site 272123005614 Magnesium ion binding site [ion binding]; other site 272123005615 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 272123005616 protein I interface; other site 272123005617 D2 interface; other site 272123005618 protein T interface; other site 272123005619 chlorophyll binding site; other site 272123005620 beta carotene binding site; other site 272123005621 pheophytin binding site; other site 272123005622 manganese-stabilizing polypeptide interface; other site 272123005623 CP43 interface; other site 272123005624 protein L interface; other site 272123005625 oxygen evolving complex binding site; other site 272123005626 bromide binding site; other site 272123005627 quinone binding site; other site 272123005628 Fe binding site [ion binding]; other site 272123005629 core light harvesting interface; other site 272123005630 cytochrome b559 alpha subunit interface; other site 272123005631 cytochrome c-550 interface; other site 272123005632 protein J interface; other site 272123005633 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 272123005634 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123005635 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123005636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123005637 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123005638 septation ring formation regulator EzrA; Provisional; Region: PRK04778 272123005639 cyanate hydratase; Validated; Region: PRK02866 272123005640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123005641 non-specific DNA binding site [nucleotide binding]; other site 272123005642 salt bridge; other site 272123005643 sequence-specific DNA binding site [nucleotide binding]; other site 272123005644 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 272123005645 oligomer interface [polypeptide binding]; other site 272123005646 active site 272123005647 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 272123005648 AAA domain; Region: AAA_30; pfam13604 272123005649 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123005650 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123005651 active site 272123005652 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123005653 active site 272123005654 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123005655 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123005656 catalytic residues [active] 272123005657 catalytic nucleophile [active] 272123005658 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123005659 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123005660 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123005661 Synaptic Site I dimer interface [polypeptide binding]; other site 272123005662 DNA binding site [nucleotide binding] 272123005663 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123005664 DNA-binding interface [nucleotide binding]; DNA binding site 272123005665 Integrase core domain; Region: rve; pfam00665 272123005666 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123005667 G5 box; other site 272123005668 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 272123005669 Endodeoxyribonuclease RusA; Region: RusA; cl01885 272123005670 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005671 putative active site [active] 272123005672 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005673 putative active site [active] 272123005674 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272123005675 active site 272123005676 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123005677 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272123005678 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 272123005679 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 272123005680 putative active site [active] 272123005681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005682 Walker A/P-loop; other site 272123005683 ATP binding site [chemical binding]; other site 272123005684 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 272123005685 inhibitor binding site; inhibition site 272123005686 catalytic motif [active] 272123005687 Catalytic residue [active] 272123005688 Active site flap [active] 272123005689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123005690 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123005691 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123005692 active site 272123005693 catalytic residues [active] 272123005694 DNA binding site [nucleotide binding] 272123005695 Int/Topo IB signature motif; other site 272123005696 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 272123005697 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 272123005698 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 272123005699 MoFe protein beta/alpha subunit interactions; other site 272123005700 Beta subunit P cluster binding residues; other site 272123005701 MoFe protein beta subunit/Fe protein contacts; other site 272123005702 MoFe protein dimer/ dimer interactions; other site 272123005703 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 272123005704 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 272123005705 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 272123005706 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 272123005707 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 272123005708 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 272123005709 Protein of unknown function, DUF269; Region: DUF269; pfam03270 272123005710 Rop-like; Region: Rop-like; pfam05082 272123005711 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 272123005712 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 272123005713 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272123005714 ATP binding site [chemical binding]; other site 272123005715 substrate interface [chemical binding]; other site 272123005716 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272123005717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123005718 catalytic loop [active] 272123005719 iron binding site [ion binding]; other site 272123005720 FeoA domain; Region: FeoA; pfam04023 272123005721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005722 putative active site [active] 272123005723 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 272123005724 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272123005725 OpgC protein; Region: OpgC_C; cl17858 272123005726 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272123005727 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272123005728 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 272123005729 NADPH bind site [chemical binding]; other site 272123005730 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 272123005731 putative FMN binding site [chemical binding]; other site 272123005732 NADPH bind site [chemical binding]; other site 272123005733 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 272123005734 nickel binding site [ion binding]; other site 272123005735 SET domain; Region: SET; pfam00856 272123005736 PIN domain; Region: PIN_3; cl17397 272123005737 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 272123005738 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 272123005739 Protein of unknown function (DUF433); Region: DUF433; cl01030 272123005740 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272123005741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123005742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123005743 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272123005744 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272123005745 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272123005746 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123005747 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 272123005748 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272123005749 uncharacterized hydrophobic domain; Region: TIGR00271 272123005750 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272123005751 ligand binding site [chemical binding]; other site 272123005752 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123005753 putative active site [active] 272123005754 threonine synthase; Reviewed; Region: PRK06721 272123005755 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 272123005756 homodimer interface [polypeptide binding]; other site 272123005757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123005758 catalytic residue [active] 272123005759 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272123005760 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272123005761 FMN binding site [chemical binding]; other site 272123005762 active site 272123005763 substrate binding site [chemical binding]; other site 272123005764 catalytic residue [active] 272123005765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 272123005766 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 272123005767 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 272123005768 active site 272123005769 catalytic triad [active] 272123005770 oxyanion hole [active] 272123005771 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272123005772 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123005773 CHASE2 domain; Region: CHASE2; pfam05226 272123005774 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123005775 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123005776 active site 272123005777 ATP binding site [chemical binding]; other site 272123005778 substrate binding site [chemical binding]; other site 272123005779 activation loop (A-loop); other site 272123005780 FAD dependent oxidoreductase; Region: DAO; pfam01266 272123005781 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 272123005782 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 272123005783 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272123005784 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272123005785 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272123005786 Fasciclin domain; Region: Fasciclin; pfam02469 272123005787 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272123005788 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 272123005789 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 272123005790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123005791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123005792 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 272123005793 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 272123005794 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123005795 M28 Zn-Peptidases; Region: M28_like_1; cd05640 272123005796 Peptidase family M28; Region: Peptidase_M28; pfam04389 272123005797 metal binding site [ion binding]; metal-binding site 272123005798 Uncharacterized conserved protein [Function unknown]; Region: COG2836 272123005799 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 272123005800 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272123005801 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272123005802 NAD binding site [chemical binding]; other site 272123005803 homodimer interface [polypeptide binding]; other site 272123005804 active site 272123005805 substrate binding site [chemical binding]; other site 272123005806 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123005807 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005809 Walker A/P-loop; other site 272123005810 ATP binding site [chemical binding]; other site 272123005811 Q-loop/lid; other site 272123005812 ABC transporter signature motif; other site 272123005813 Walker B; other site 272123005814 D-loop; other site 272123005815 H-loop/switch region; other site 272123005816 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272123005817 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272123005818 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272123005819 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272123005820 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272123005821 catalytic residue [active] 272123005822 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 272123005823 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272123005824 hypothetical protein; Validated; Region: PRK00110 272123005825 signal recognition particle protein; Provisional; Region: PRK10867 272123005826 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272123005827 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272123005828 GTP binding site [chemical binding]; other site 272123005829 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272123005830 ribosomal protein S16; Region: rps16; CHL00005 272123005831 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272123005832 KH domain; Region: KH_4; pfam13083 272123005833 G-X-X-G motif; other site 272123005834 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272123005835 PhoH-like protein; Region: PhoH; pfam02562 272123005836 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 272123005837 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123005838 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123005839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005840 Walker A/P-loop; other site 272123005841 ATP binding site [chemical binding]; other site 272123005842 Q-loop/lid; other site 272123005843 ABC transporter signature motif; other site 272123005844 Walker B; other site 272123005845 D-loop; other site 272123005846 H-loop/switch region; other site 272123005847 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272123005848 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 272123005849 adenylate kinase; Provisional; Region: adk; PRK02496 272123005850 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272123005851 AMP-binding site [chemical binding]; other site 272123005852 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272123005853 ribonuclease PH; Reviewed; Region: rph; PRK00173 272123005854 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272123005855 hexamer interface [polypeptide binding]; other site 272123005856 active site 272123005857 Permease; Region: Permease; cl00510 272123005858 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272123005859 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272123005860 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272123005861 putative active site [active] 272123005862 Double zinc ribbon; Region: DZR; pfam12773 272123005863 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 272123005864 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272123005865 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123005866 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123005867 phosphopeptide binding site; other site 272123005868 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 272123005869 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272123005870 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 272123005871 putative ligand binding site [chemical binding]; other site 272123005872 putative NAD binding site [chemical binding]; other site 272123005873 catalytic site [active] 272123005874 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123005875 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123005876 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123005877 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123005878 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272123005879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 272123005880 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123005881 anti sigma factor interaction site; other site 272123005882 regulatory phosphorylation site [posttranslational modification]; other site 272123005883 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 272123005884 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 272123005885 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272123005886 active site 272123005887 catalytic site [active] 272123005888 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123005889 anti sigma factor interaction site; other site 272123005890 regulatory phosphorylation site [posttranslational modification]; other site 272123005891 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 272123005892 dimerization interface [polypeptide binding]; other site 272123005893 putative active cleft [active] 272123005894 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272123005895 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272123005896 conserved cys residue [active] 272123005897 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272123005898 EthD domain; Region: EthD; pfam07110 272123005899 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272123005900 active site 272123005901 metal binding site [ion binding]; metal-binding site 272123005902 SnoaL-like domain; Region: SnoaL_2; pfam12680 272123005903 SnoaL-like domain; Region: SnoaL_2; pfam12680 272123005904 EthD domain; Region: EthD; pfam07110 272123005905 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272123005906 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272123005907 Cation efflux family; Region: Cation_efflux; cl00316 272123005908 S-layer homology domain; Region: SLH; pfam00395 272123005909 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 272123005910 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 272123005911 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123005912 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 272123005913 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272123005914 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123005915 CHASE2 domain; Region: CHASE2; pfam05226 272123005916 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123005917 cyclase homology domain; Region: CHD; cd07302 272123005918 nucleotidyl binding site; other site 272123005919 metal binding site [ion binding]; metal-binding site 272123005920 dimer interface [polypeptide binding]; other site 272123005921 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123005922 TPR repeat; Region: TPR_11; pfam13414 272123005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005924 binding surface 272123005925 TPR repeat; Region: TPR_11; pfam13414 272123005926 TPR motif; other site 272123005927 TPR repeat; Region: TPR_11; pfam13414 272123005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005929 binding surface 272123005930 TPR motif; other site 272123005931 TPR repeat; Region: TPR_11; pfam13414 272123005932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005933 binding surface 272123005934 TPR repeat; Region: TPR_11; pfam13414 272123005935 TPR motif; other site 272123005936 TPR repeat; Region: TPR_11; pfam13414 272123005937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123005938 TPR motif; other site 272123005939 binding surface 272123005940 Tetratricopeptide repeat; Region: TPR_9; pfam13371 272123005941 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 272123005942 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 272123005943 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272123005944 Bacterial Ig-like domain; Region: Big_5; pfam13205 272123005945 MG2 domain; Region: A2M_N; pfam01835 272123005946 Alpha-2-macroglobulin family; Region: A2M; pfam00207 272123005947 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272123005948 surface patch; other site 272123005949 specificity defining residues; other site 272123005950 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 272123005951 Transglycosylase; Region: Transgly; pfam00912 272123005952 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272123005953 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272123005954 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 272123005955 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272123005956 putative NAD(P) binding site [chemical binding]; other site 272123005957 putative active site [active] 272123005958 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272123005959 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272123005960 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 272123005961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123005962 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 272123005963 putative hydrophobic ligand binding site [chemical binding]; other site 272123005964 Lipoxygenase; Region: Lipoxygenase; pfam00305 272123005965 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123005966 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123005967 catalytic loop [active] 272123005968 iron binding site [ion binding]; other site 272123005969 cobyric acid synthase; Provisional; Region: PRK00784 272123005970 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272123005971 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272123005972 catalytic triad [active] 272123005973 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272123005974 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123005975 catalytic triad [active] 272123005976 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272123005977 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272123005978 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272123005979 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123005980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123005981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123005982 Walker A/P-loop; other site 272123005983 ATP binding site [chemical binding]; other site 272123005984 Q-loop/lid; other site 272123005985 ABC transporter signature motif; other site 272123005986 Walker B; other site 272123005987 D-loop; other site 272123005988 H-loop/switch region; other site 272123005989 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123005990 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005991 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123005996 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 272123005997 putative hexamer interface [polypeptide binding]; other site 272123005998 putative hexagonal pore; other site 272123005999 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 272123006000 Hexamer interface [polypeptide binding]; other site 272123006001 Hexagonal pore residue; other site 272123006002 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 272123006003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123006004 Walker A motif; other site 272123006005 ATP binding site [chemical binding]; other site 272123006006 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272123006007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123006008 putative metal binding site; other site 272123006009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006010 TPR motif; other site 272123006011 TPR repeat; Region: TPR_11; pfam13414 272123006012 binding surface 272123006013 aspartate aminotransferase; Provisional; Region: PRK05764 272123006014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123006015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123006016 homodimer interface [polypeptide binding]; other site 272123006017 catalytic residue [active] 272123006018 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272123006019 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272123006020 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272123006021 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272123006022 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123006023 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272123006024 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 272123006025 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123006026 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 272123006027 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123006028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123006029 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123006030 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006031 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006033 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272123006034 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272123006035 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272123006036 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272123006037 phosphoribulokinase; Provisional; Region: PRK07429 272123006038 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 272123006039 active site 272123006040 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 272123006041 ferredoxin--NADP(+) reductase; Provisional; Region: PLN03115 272123006042 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 272123006043 dimerization interface [polypeptide binding]; other site 272123006044 FAD binding pocket [chemical binding]; other site 272123006045 FAD binding motif [chemical binding]; other site 272123006046 catalytic residues [active] 272123006047 NAD binding pocket [chemical binding]; other site 272123006048 phosphate binding motif [ion binding]; other site 272123006049 beta-alpha-beta structure motif; other site 272123006050 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272123006051 homoserine dehydrogenase; Provisional; Region: PRK06349 272123006052 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272123006053 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272123006054 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 272123006055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123006056 dimerization interface [polypeptide binding]; other site 272123006057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006058 dimer interface [polypeptide binding]; other site 272123006059 phosphorylation site [posttranslational modification] 272123006060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006061 ATP binding site [chemical binding]; other site 272123006062 Mg2+ binding site [ion binding]; other site 272123006063 G-X-G motif; other site 272123006064 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272123006065 Part of AAA domain; Region: AAA_19; pfam13245 272123006066 Family description; Region: UvrD_C_2; pfam13538 272123006067 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 272123006068 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 272123006069 putative active site [active] 272123006070 putative metal binding site [ion binding]; other site 272123006071 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272123006072 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 272123006073 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 272123006074 NADPH bind site [chemical binding]; other site 272123006075 putative FMN binding site [chemical binding]; other site 272123006076 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 272123006077 putative FMN binding site [chemical binding]; other site 272123006078 NADPH bind site [chemical binding]; other site 272123006079 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123006080 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123006081 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123006082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123006083 active site 272123006084 substrate binding site [chemical binding]; other site 272123006085 ATP binding site [chemical binding]; other site 272123006086 activation loop (A-loop); other site 272123006087 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123006088 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 272123006089 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 272123006090 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 272123006091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123006092 Walker A/P-loop; other site 272123006093 ATP binding site [chemical binding]; other site 272123006094 Q-loop/lid; other site 272123006095 ABC transporter signature motif; other site 272123006096 Walker B; other site 272123006097 D-loop; other site 272123006098 H-loop/switch region; other site 272123006099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123006100 metal binding site [ion binding]; metal-binding site 272123006101 active site 272123006102 I-site; other site 272123006103 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272123006104 ABC1 family; Region: ABC1; cl17513 272123006105 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272123006106 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272123006107 Substrate binding site; other site 272123006108 Cupin domain; Region: Cupin_2; cl17218 272123006109 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272123006110 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272123006111 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006112 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006113 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006115 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272123006116 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272123006117 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123006118 putative active site [active] 272123006119 Protein of unknown function DUF89; Region: DUF89; pfam01937 272123006120 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272123006121 active site 272123006122 metal binding site [ion binding]; metal-binding site 272123006123 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 272123006124 Predicted membrane protein [Function unknown]; Region: COG1950 272123006125 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123006126 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123006127 catalytic loop [active] 272123006128 iron binding site [ion binding]; other site 272123006129 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272123006130 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272123006131 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272123006132 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272123006133 RNA binding site [nucleotide binding]; other site 272123006134 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272123006135 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272123006136 Cl- selectivity filter; other site 272123006137 Cl- binding residues [ion binding]; other site 272123006138 pore gating glutamate residue; other site 272123006139 dimer interface [polypeptide binding]; other site 272123006140 H+/Cl- coupling transport residue; other site 272123006141 FOG: CBS domain [General function prediction only]; Region: COG0517 272123006142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 272123006143 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 272123006144 Ligand Binding Site [chemical binding]; other site 272123006145 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123006146 Ligand Binding Site [chemical binding]; other site 272123006147 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123006148 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123006149 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 272123006150 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123006151 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272123006152 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123006153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123006154 acyl-activating enzyme (AAE) consensus motif; other site 272123006155 AMP binding site [chemical binding]; other site 272123006156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123006157 Condensation domain; Region: Condensation; pfam00668 272123006158 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123006159 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123006160 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123006161 acyl-activating enzyme (AAE) consensus motif; other site 272123006162 AMP binding site [chemical binding]; other site 272123006163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123006164 Condensation domain; Region: Condensation; pfam00668 272123006165 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123006166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123006167 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 272123006168 acyl-activating enzyme (AAE) consensus motif; other site 272123006169 AMP binding site [chemical binding]; other site 272123006170 Cna protein B-type domain; Region: Cna_B; pfam05738 272123006171 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 272123006172 conserved repeat domain; Region: B_ant_repeat; TIGR01451 272123006173 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 272123006174 conserved repeat domain; Region: B_ant_repeat; TIGR01451 272123006175 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272123006176 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123006177 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 272123006178 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272123006179 active site 272123006180 interdomain interaction site; other site 272123006181 putative metal-binding site [ion binding]; other site 272123006182 nucleotide binding site [chemical binding]; other site 272123006183 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272123006184 domain I; other site 272123006185 DNA binding groove [nucleotide binding] 272123006186 phosphate binding site [ion binding]; other site 272123006187 domain II; other site 272123006188 domain III; other site 272123006189 nucleotide binding site [chemical binding]; other site 272123006190 catalytic site [active] 272123006191 domain IV; other site 272123006192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272123006193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272123006194 putative acyl-acceptor binding pocket; other site 272123006195 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272123006196 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 272123006197 active site 272123006198 catalytic site [active] 272123006199 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272123006200 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 272123006201 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 272123006202 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 272123006203 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 272123006204 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272123006205 putative active site [active] 272123006206 catalytic residue [active] 272123006207 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272123006208 Predicted methyltransferases [General function prediction only]; Region: COG0313 272123006209 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272123006210 putative SAM binding site [chemical binding]; other site 272123006211 putative homodimer interface [polypeptide binding]; other site 272123006212 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 272123006213 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 272123006214 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123006215 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 272123006216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272123006217 substrate binding site [chemical binding]; other site 272123006218 ATP binding site [chemical binding]; other site 272123006219 MASE1; Region: MASE1; cl17823 272123006220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006221 dimer interface [polypeptide binding]; other site 272123006222 phosphorylation site [posttranslational modification] 272123006223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006224 ATP binding site [chemical binding]; other site 272123006225 Mg2+ binding site [ion binding]; other site 272123006226 G-X-G motif; other site 272123006227 Response regulator receiver domain; Region: Response_reg; pfam00072 272123006228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123006229 active site 272123006230 phosphorylation site [posttranslational modification] 272123006231 intermolecular recognition site; other site 272123006232 dimerization interface [polypeptide binding]; other site 272123006233 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272123006234 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272123006235 active site 272123006236 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 272123006237 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272123006238 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272123006239 iron-sulfur cluster [ion binding]; other site 272123006240 [2Fe-2S] cluster binding site [ion binding]; other site 272123006241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123006242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123006243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272123006244 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272123006245 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 272123006246 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 272123006247 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272123006248 active site 272123006249 dimer interface [polypeptide binding]; other site 272123006250 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272123006251 dimer interface [polypeptide binding]; other site 272123006252 active site 272123006253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123006254 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123006255 putative active site [active] 272123006256 heme pocket [chemical binding]; other site 272123006257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123006258 putative active site [active] 272123006259 heme pocket [chemical binding]; other site 272123006260 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272123006261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123006262 putative active site [active] 272123006263 heme pocket [chemical binding]; other site 272123006264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006265 dimer interface [polypeptide binding]; other site 272123006266 phosphorylation site [posttranslational modification] 272123006267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006268 ATP binding site [chemical binding]; other site 272123006269 Mg2+ binding site [ion binding]; other site 272123006270 G-X-G motif; other site 272123006271 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272123006272 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272123006273 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272123006274 TM-ABC transporter signature motif; other site 272123006275 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272123006276 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272123006277 Walker A/P-loop; other site 272123006278 ATP binding site [chemical binding]; other site 272123006279 Q-loop/lid; other site 272123006280 ABC transporter signature motif; other site 272123006281 Walker B; other site 272123006282 D-loop; other site 272123006283 H-loop/switch region; other site 272123006284 YcfA-like protein; Region: YcfA; cl00752 272123006285 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272123006286 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272123006287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272123006288 active site residue [active] 272123006289 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272123006290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272123006291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123006292 dimerization interface [polypeptide binding]; other site 272123006293 putative DNA binding site [nucleotide binding]; other site 272123006294 putative Zn2+ binding site [ion binding]; other site 272123006295 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272123006296 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272123006297 tRNA; other site 272123006298 putative tRNA binding site [nucleotide binding]; other site 272123006299 putative NADP binding site [chemical binding]; other site 272123006300 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 272123006301 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272123006302 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 272123006303 putative active site [active] 272123006304 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272123006305 GSH binding site [chemical binding]; other site 272123006306 catalytic residues [active] 272123006307 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272123006308 nucleoside/Zn binding site; other site 272123006309 dimer interface [polypeptide binding]; other site 272123006310 catalytic motif [active] 272123006311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272123006312 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272123006313 putative acyl-acceptor binding pocket; other site 272123006314 CHAT domain; Region: CHAT; cl17868 272123006315 AAA ATPase domain; Region: AAA_16; pfam13191 272123006316 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123006317 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123006318 structural tetrad; other site 272123006319 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123006320 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123006321 structural tetrad; other site 272123006322 WD domain, G-beta repeat; Region: WD40; pfam00400 272123006323 WD40 repeats; Region: WD40; smart00320 272123006324 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 272123006325 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 272123006326 active site 272123006327 catalytic triad [active] 272123006328 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 272123006329 BolA-like protein; Region: BolA; pfam01722 272123006330 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272123006331 putative GSH binding site [chemical binding]; other site 272123006332 catalytic residues [active] 272123006333 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 272123006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123006335 putative substrate translocation pore; other site 272123006336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123006337 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 272123006338 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 272123006339 active site 272123006340 catalytic residues [active] 272123006341 metal binding site [ion binding]; metal-binding site 272123006342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123006343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123006344 active site 272123006345 phosphorylation site [posttranslational modification] 272123006346 intermolecular recognition site; other site 272123006347 dimerization interface [polypeptide binding]; other site 272123006348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123006349 DNA binding site [nucleotide binding] 272123006350 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272123006351 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272123006352 Walker A/P-loop; other site 272123006353 ATP binding site [chemical binding]; other site 272123006354 Q-loop/lid; other site 272123006355 ABC transporter signature motif; other site 272123006356 Walker B; other site 272123006357 D-loop; other site 272123006358 H-loop/switch region; other site 272123006359 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 272123006360 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 272123006361 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272123006362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123006363 FeS/SAM binding site; other site 272123006364 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 272123006365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272123006366 Zn2+ binding site [ion binding]; other site 272123006367 Mg2+ binding site [ion binding]; other site 272123006368 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006369 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006370 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006371 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006373 CAAX protease self-immunity; Region: Abi; pfam02517 272123006374 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 272123006375 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 272123006376 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272123006377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123006378 FeS/SAM binding site; other site 272123006379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 272123006380 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 272123006381 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272123006382 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272123006383 homodimer interface [polypeptide binding]; other site 272123006384 oligonucleotide binding site [chemical binding]; other site 272123006385 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272123006386 RNA/DNA hybrid binding site [nucleotide binding]; other site 272123006387 active site 272123006388 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 272123006389 prephenate dehydratase; Provisional; Region: PRK11898 272123006390 Prephenate dehydratase; Region: PDT; pfam00800 272123006391 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272123006392 putative L-Phe binding site [chemical binding]; other site 272123006393 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 272123006394 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272123006395 elongation factor Tu; Region: tufA; CHL00071 272123006396 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272123006397 G1 box; other site 272123006398 GEF interaction site [polypeptide binding]; other site 272123006399 GTP/Mg2+ binding site [chemical binding]; other site 272123006400 Switch I region; other site 272123006401 G2 box; other site 272123006402 G3 box; other site 272123006403 Switch II region; other site 272123006404 G4 box; other site 272123006405 G5 box; other site 272123006406 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272123006407 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272123006408 Antibiotic Binding Site [chemical binding]; other site 272123006409 elongation factor G; Reviewed; Region: PRK00007 272123006410 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272123006411 G1 box; other site 272123006412 putative GEF interaction site [polypeptide binding]; other site 272123006413 GTP/Mg2+ binding site [chemical binding]; other site 272123006414 Switch I region; other site 272123006415 G2 box; other site 272123006416 G3 box; other site 272123006417 Switch II region; other site 272123006418 G4 box; other site 272123006419 G5 box; other site 272123006420 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272123006421 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272123006422 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272123006423 30S ribosomal protein S7; Validated; Region: PRK05302 272123006424 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272123006425 S17 interaction site [polypeptide binding]; other site 272123006426 S8 interaction site; other site 272123006427 16S rRNA interaction site [nucleotide binding]; other site 272123006428 streptomycin interaction site [chemical binding]; other site 272123006429 23S rRNA interaction site [nucleotide binding]; other site 272123006430 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272123006431 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272123006432 Cupin domain; Region: Cupin_2; cl17218 272123006433 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272123006434 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272123006435 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272123006436 active site 272123006437 dimer interface [polypeptide binding]; other site 272123006438 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272123006439 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272123006440 active site 272123006441 FMN binding site [chemical binding]; other site 272123006442 substrate binding site [chemical binding]; other site 272123006443 3Fe-4S cluster binding site [ion binding]; other site 272123006444 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272123006445 domain interface; other site 272123006446 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272123006447 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272123006448 NodB motif; other site 272123006449 active site 272123006450 catalytic site [active] 272123006451 metal binding site [ion binding]; metal-binding site 272123006452 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272123006453 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272123006454 Ligand binding site; other site 272123006455 Putative Catalytic site; other site 272123006456 DXD motif; other site 272123006457 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123006458 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123006459 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123006460 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 272123006461 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272123006462 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272123006463 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272123006464 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272123006465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123006466 AAA domain; Region: AAA_21; pfam13304 272123006467 Walker A/P-loop; other site 272123006468 ATP binding site [chemical binding]; other site 272123006469 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272123006470 active site 272123006471 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 272123006472 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 272123006473 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272123006474 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272123006475 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272123006476 CbbX; Provisional; Region: cbbX; CHL00181 272123006477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123006478 Walker A motif; other site 272123006479 ATP binding site [chemical binding]; other site 272123006480 Walker B motif; other site 272123006481 arginine finger; other site 272123006482 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272123006483 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123006484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006486 binding surface 272123006487 TPR motif; other site 272123006488 TPR repeat; Region: TPR_11; pfam13414 272123006489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006490 binding surface 272123006491 TPR motif; other site 272123006492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006494 CHAT domain; Region: CHAT; pfam12770 272123006495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272123006496 active site 272123006497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006498 binding surface 272123006499 TPR motif; other site 272123006500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006501 binding surface 272123006502 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006503 TPR motif; other site 272123006504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006506 binding surface 272123006507 TPR motif; other site 272123006508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006509 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 272123006510 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272123006511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006512 dimer interface [polypeptide binding]; other site 272123006513 phosphorylation site [posttranslational modification] 272123006514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006515 ATP binding site [chemical binding]; other site 272123006516 Mg2+ binding site [ion binding]; other site 272123006517 G-X-G motif; other site 272123006518 polyphosphate kinase; Provisional; Region: PRK05443 272123006519 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272123006520 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272123006521 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272123006522 putative domain interface [polypeptide binding]; other site 272123006523 putative active site [active] 272123006524 catalytic site [active] 272123006525 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272123006526 putative domain interface [polypeptide binding]; other site 272123006527 putative active site [active] 272123006528 catalytic site [active] 272123006529 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123006530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123006531 active site 272123006532 phosphorylation site [posttranslational modification] 272123006533 intermolecular recognition site; other site 272123006534 dimerization interface [polypeptide binding]; other site 272123006535 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 272123006536 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 272123006537 adaptive-response sensory kinase; Validated; Region: PRK09303 272123006538 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272123006539 tetramer interface [polypeptide binding]; other site 272123006540 dimer interface [polypeptide binding]; other site 272123006541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006542 dimer interface [polypeptide binding]; other site 272123006543 phosphorylation site [posttranslational modification] 272123006544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006545 ATP binding site [chemical binding]; other site 272123006546 Mg2+ binding site [ion binding]; other site 272123006547 G-X-G motif; other site 272123006548 S-layer homology domain; Region: SLH; pfam00395 272123006549 S-layer homology domain; Region: SLH; pfam00395 272123006550 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 272123006551 active site 272123006552 catalytic triad [active] 272123006553 oxyanion hole [active] 272123006554 hypothetical protein; Provisional; Region: PRK06208 272123006555 intersubunit interface [polypeptide binding]; other site 272123006556 active site 272123006557 Zn2+ binding site [ion binding]; other site 272123006558 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006559 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006560 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123006561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006565 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006566 tyrosine kinase; Provisional; Region: PRK11519 272123006567 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 272123006568 putative homodimer interface [polypeptide binding]; other site 272123006569 putative active site pocket [active] 272123006570 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 272123006571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006574 binding surface 272123006575 TPR motif; other site 272123006576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006578 binding surface 272123006579 TPR motif; other site 272123006580 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123006582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123006583 binding surface 272123006584 TPR motif; other site 272123006585 CHAT domain; Region: CHAT; pfam12770 272123006586 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 272123006587 Conserved TM helix; Region: TM_helix; pfam05552 272123006588 Conserved TM helix; Region: TM_helix; pfam05552 272123006589 Conserved TM helix; Region: TM_helix; pfam05552 272123006590 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272123006592 active site 272123006593 phosphorylation site [posttranslational modification] 272123006594 intermolecular recognition site; other site 272123006595 dimerization interface [polypeptide binding]; other site 272123006596 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 272123006597 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 272123006598 G1 box; other site 272123006599 GTP/Mg2+ binding site [chemical binding]; other site 272123006600 Switch I region; other site 272123006601 G2 box; other site 272123006602 Switch II region; other site 272123006603 G3 box; other site 272123006604 G4 box; other site 272123006605 G5 box; other site 272123006606 Domain of unknown function (DUF697); Region: DUF697; pfam05128 272123006607 Response regulator receiver domain; Region: Response_reg; pfam00072 272123006608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123006609 active site 272123006610 phosphorylation site [posttranslational modification] 272123006611 intermolecular recognition site; other site 272123006612 dimerization interface [polypeptide binding]; other site 272123006613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123006614 metal binding site [ion binding]; metal-binding site 272123006615 I-site; other site 272123006616 active site 272123006617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123006618 FOG: CBS domain [General function prediction only]; Region: COG0517 272123006619 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 272123006620 FOG: CBS domain [General function prediction only]; Region: COG0517 272123006621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 272123006622 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123006623 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123006624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123006625 PAS fold; Region: PAS_3; pfam08447 272123006626 putative active site [active] 272123006627 heme pocket [chemical binding]; other site 272123006628 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123006629 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123006630 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123006631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123006632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123006633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006634 dimer interface [polypeptide binding]; other site 272123006635 phosphorylation site [posttranslational modification] 272123006636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123006637 ATP binding site [chemical binding]; other site 272123006638 Mg2+ binding site [ion binding]; other site 272123006639 G-X-G motif; other site 272123006640 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123006641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123006642 S-adenosylmethionine binding site [chemical binding]; other site 272123006643 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272123006644 triosephosphate isomerase; Provisional; Region: PRK14565 272123006645 dimer interface [polypeptide binding]; other site 272123006646 substrate binding site [chemical binding]; other site 272123006647 catalytic triad [active] 272123006648 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272123006649 dihydropteroate synthase; Region: DHPS; TIGR01496 272123006650 substrate binding pocket [chemical binding]; other site 272123006651 dimer interface [polypeptide binding]; other site 272123006652 inhibitor binding site; inhibition site 272123006653 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123006654 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272123006655 Uncharacterized conserved protein [Function unknown]; Region: COG4279 272123006656 SWIM zinc finger; Region: SWIM; pfam04434 272123006657 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272123006658 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123006659 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272123006660 SNF2 Helicase protein; Region: DUF3670; pfam12419 272123006661 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123006662 protein-splicing catalytic site; other site 272123006663 thioester formation/cholesterol transfer; other site 272123006664 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272123006665 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123006666 protein-splicing catalytic site; other site 272123006667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123006668 putative Mg++ binding site [ion binding]; other site 272123006669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123006670 nucleotide binding region [chemical binding]; other site 272123006671 ATP-binding site [chemical binding]; other site 272123006672 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272123006673 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 272123006674 putative active site [active] 272123006675 XisI protein; Region: XisI; pfam08869 272123006676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123006677 Walker A/P-loop; other site 272123006678 ATP binding site [chemical binding]; other site 272123006679 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272123006680 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272123006681 RNase E interface [polypeptide binding]; other site 272123006682 trimer interface [polypeptide binding]; other site 272123006683 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272123006684 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272123006685 RNase E interface [polypeptide binding]; other site 272123006686 trimer interface [polypeptide binding]; other site 272123006687 active site 272123006688 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272123006689 putative nucleic acid binding region [nucleotide binding]; other site 272123006690 G-X-X-G motif; other site 272123006691 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272123006692 RNA binding site [nucleotide binding]; other site 272123006693 domain interface; other site 272123006694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006695 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123006696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006697 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 272123006698 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272123006699 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 272123006700 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 272123006701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123006702 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 272123006703 ligand binding site [chemical binding]; other site 272123006704 flexible hinge region; other site 272123006705 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272123006706 putative switch regulator; other site 272123006707 non-specific DNA interactions [nucleotide binding]; other site 272123006708 DNA binding site [nucleotide binding] 272123006709 sequence specific DNA binding site [nucleotide binding]; other site 272123006710 putative cAMP binding site [chemical binding]; other site 272123006711 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 272123006712 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272123006713 NAD binding site [chemical binding]; other site 272123006714 homotetramer interface [polypeptide binding]; other site 272123006715 homodimer interface [polypeptide binding]; other site 272123006716 substrate binding site [chemical binding]; other site 272123006717 active site 272123006718 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 272123006719 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272123006720 putative active site pocket [active] 272123006721 4-fold oligomerization interface [polypeptide binding]; other site 272123006722 metal binding residues [ion binding]; metal-binding site 272123006723 3-fold/trimer interface [polypeptide binding]; other site 272123006724 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272123006725 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123006726 Walker A/P-loop; other site 272123006727 ATP binding site [chemical binding]; other site 272123006728 Q-loop/lid; other site 272123006729 ABC transporter signature motif; other site 272123006730 Walker B; other site 272123006731 D-loop; other site 272123006732 H-loop/switch region; other site 272123006733 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272123006734 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 272123006735 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 272123006736 SLBB domain; Region: SLBB; pfam10531 272123006737 photosystem II 44 kDa protein; Region: psbC; CHL00035 272123006738 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 272123006739 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 272123006740 D1 interface; other site 272123006741 chlorophyll binding site; other site 272123006742 pheophytin binding site; other site 272123006743 beta carotene binding site; other site 272123006744 cytochrome b559 beta interface; other site 272123006745 quinone binding site; other site 272123006746 cytochrome b559 alpha interface; other site 272123006747 protein J interface; other site 272123006748 protein H interface; other site 272123006749 protein X interface; other site 272123006750 core light harvesting protein interface; other site 272123006751 protein L interface; other site 272123006752 CP43 interface; other site 272123006753 protein T interface; other site 272123006754 Fe binding site [ion binding]; other site 272123006755 protein M interface; other site 272123006756 Mn-stabilizing polypeptide interface; other site 272123006757 bromide binding site; other site 272123006758 cytochrome c-550 interface; other site 272123006759 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 272123006760 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 272123006761 active site 272123006762 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 272123006763 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272123006764 dimer interface [polypeptide binding]; other site 272123006765 active site 272123006766 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123006767 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123006768 CHASE2 domain; Region: CHASE2; pfam05226 272123006769 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123006770 cyclase homology domain; Region: CHD; cd07302 272123006771 nucleotidyl binding site; other site 272123006772 metal binding site [ion binding]; metal-binding site 272123006773 dimer interface [polypeptide binding]; other site 272123006774 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272123006775 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272123006776 NAD(P) binding site [chemical binding]; other site 272123006777 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123006778 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123006779 active site 272123006780 ATP binding site [chemical binding]; other site 272123006781 substrate binding site [chemical binding]; other site 272123006782 activation loop (A-loop); other site 272123006783 YARHG domain; Region: YARHG; pfam13308 272123006784 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 272123006785 GIY-YIG motif/motif A; other site 272123006786 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 272123006787 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272123006788 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272123006789 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272123006790 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272123006791 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272123006792 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272123006793 DNA binding site [nucleotide binding] 272123006794 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272123006795 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 272123006796 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272123006797 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272123006798 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272123006799 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272123006800 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272123006801 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272123006802 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272123006803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272123006804 RPB10 interaction site [polypeptide binding]; other site 272123006805 RPB1 interaction site [polypeptide binding]; other site 272123006806 RPB11 interaction site [polypeptide binding]; other site 272123006807 RPB3 interaction site [polypeptide binding]; other site 272123006808 RPB12 interaction site [polypeptide binding]; other site 272123006809 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272123006810 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272123006811 active site 272123006812 ribosomal protein S20; Region: rps20; CHL00102 272123006813 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272123006814 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272123006815 NAD binding site [chemical binding]; other site 272123006816 dimerization interface [polypeptide binding]; other site 272123006817 product binding site; other site 272123006818 substrate binding site [chemical binding]; other site 272123006819 zinc binding site [ion binding]; other site 272123006820 catalytic residues [active] 272123006821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123006822 Ligand Binding Site [chemical binding]; other site 272123006823 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272123006824 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272123006825 dimerization interface [polypeptide binding]; other site 272123006826 domain crossover interface; other site 272123006827 redox-dependent activation switch; other site 272123006828 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272123006829 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123006830 putative active site [active] 272123006831 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 272123006832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123006833 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272123006834 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 272123006835 G1 box; other site 272123006836 GTP/Mg2+ binding site [chemical binding]; other site 272123006837 G2 box; other site 272123006838 Switch I region; other site 272123006839 G3 box; other site 272123006840 Switch II region; other site 272123006841 G4 box; other site 272123006842 G5 box; other site 272123006843 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 272123006844 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123006845 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123006846 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123006847 Phosphotransferase enzyme family; Region: APH; pfam01636 272123006848 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272123006849 active site 272123006850 substrate binding site [chemical binding]; other site 272123006851 ATP binding site [chemical binding]; other site 272123006852 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272123006853 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272123006854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123006855 active site 272123006856 ATP binding site [chemical binding]; other site 272123006857 substrate binding site [chemical binding]; other site 272123006858 activation loop (A-loop); other site 272123006859 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272123006860 peripheral dimer interface [polypeptide binding]; other site 272123006861 core dimer interface [polypeptide binding]; other site 272123006862 L10 interface [polypeptide binding]; other site 272123006863 L11 interface [polypeptide binding]; other site 272123006864 putative EF-Tu interaction site [polypeptide binding]; other site 272123006865 putative EF-G interaction site [polypeptide binding]; other site 272123006866 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272123006867 23S rRNA interface [nucleotide binding]; other site 272123006868 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272123006869 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272123006870 mRNA/rRNA interface [nucleotide binding]; other site 272123006871 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272123006872 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272123006873 23S rRNA interface [nucleotide binding]; other site 272123006874 L7/L12 interface [polypeptide binding]; other site 272123006875 putative thiostrepton binding site; other site 272123006876 L25 interface [polypeptide binding]; other site 272123006877 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272123006878 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272123006879 putative homodimer interface [polypeptide binding]; other site 272123006880 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272123006881 heterodimer interface [polypeptide binding]; other site 272123006882 homodimer interface [polypeptide binding]; other site 272123006883 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272123006884 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272123006885 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123006886 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123006887 active site 272123006888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123006889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123006890 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 272123006891 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272123006892 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123006893 CpeS-like protein; Region: CpeS; pfam09367 272123006894 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 272123006895 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 272123006896 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123006897 putative active site [active] 272123006898 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272123006899 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272123006900 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123006901 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272123006902 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272123006903 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272123006904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123006905 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272123006906 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272123006907 pantothenate kinase; Reviewed; Region: PRK13331 272123006908 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123006909 oligomeric interface; other site 272123006910 putative active site [active] 272123006911 homodimer interface [polypeptide binding]; other site 272123006912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272123006913 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272123006914 catalytic site [active] 272123006915 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272123006916 nudix motif; other site 272123006917 argininosuccinate lyase; Provisional; Region: PRK00855 272123006918 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272123006919 active sites [active] 272123006920 tetramer interface [polypeptide binding]; other site 272123006921 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 272123006922 AIR carboxylase; Region: AIRC; smart01001 272123006923 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272123006924 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 272123006925 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272123006926 homotrimer interaction site [polypeptide binding]; other site 272123006927 zinc binding site [ion binding]; other site 272123006928 CDP-binding sites; other site 272123006929 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272123006930 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 272123006931 proposed catalytic triad [active] 272123006932 active site nucleophile [active] 272123006933 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 272123006934 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272123006935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123006936 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123006937 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 272123006938 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123006939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123006940 active site 272123006941 ATP binding site [chemical binding]; other site 272123006942 substrate binding site [chemical binding]; other site 272123006943 activation loop (A-loop); other site 272123006944 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123006945 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123006946 active site 272123006947 ATP binding site [chemical binding]; other site 272123006948 substrate binding site [chemical binding]; other site 272123006949 activation loop (A-loop); other site 272123006950 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 272123006951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123006952 S-adenosylmethionine binding site [chemical binding]; other site 272123006953 phosphatidate cytidylyltransferase; Region: PLN02953 272123006954 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272123006955 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 272123006956 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272123006957 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123006958 RNA binding surface [nucleotide binding]; other site 272123006959 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272123006960 active site 272123006961 Helix-turn-helix domain; Region: HTH_25; pfam13413 272123006962 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272123006963 4-alpha-glucanotransferase; Provisional; Region: PRK14508 272123006964 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272123006965 nudix motif; other site 272123006966 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123006967 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006968 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006969 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006970 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006971 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006972 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123006974 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272123006975 homotrimer interaction site [polypeptide binding]; other site 272123006976 putative active site [active] 272123006977 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272123006978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123006979 active site 272123006980 metal binding site [ion binding]; metal-binding site 272123006981 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 272123006982 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 272123006983 L-aspartate oxidase; Provisional; Region: PRK06175 272123006984 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272123006985 XisI protein; Region: XisI; pfam08869 272123006986 FAD binding domain; Region: FAD_binding_4; pfam01565 272123006987 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 272123006988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 272123006989 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123006990 PAS fold; Region: PAS_4; pfam08448 272123006991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123006992 putative active site [active] 272123006993 heme pocket [chemical binding]; other site 272123006994 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123006995 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123006996 GAF domain; Region: GAF; cl17456 272123006997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123006998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123006999 dimer interface [polypeptide binding]; other site 272123007000 phosphorylation site [posttranslational modification] 272123007001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007002 ATP binding site [chemical binding]; other site 272123007003 Mg2+ binding site [ion binding]; other site 272123007004 G-X-G motif; other site 272123007005 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123007006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007008 binding surface 272123007009 TPR motif; other site 272123007010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007013 TPR motif; other site 272123007014 binding surface 272123007015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007016 binding surface 272123007017 TPR motif; other site 272123007018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007021 binding surface 272123007022 TPR motif; other site 272123007023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007025 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123007026 enolase; Provisional; Region: eno; PRK00077 272123007027 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272123007028 dimer interface [polypeptide binding]; other site 272123007029 metal binding site [ion binding]; metal-binding site 272123007030 substrate binding pocket [chemical binding]; other site 272123007031 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 272123007032 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272123007033 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 272123007034 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272123007035 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272123007036 dimerization interface [polypeptide binding]; other site 272123007037 active site 272123007038 Predicted ATPases [General function prediction only]; Region: COG1106 272123007039 P-loop containing region of AAA domain; Region: AAA_29; cl17516 272123007040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007041 ABC transporter signature motif; other site 272123007042 Walker B; other site 272123007043 D-loop; other site 272123007044 H-loop/switch region; other site 272123007045 RloB-like protein; Region: RloB; pfam13707 272123007046 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 272123007047 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272123007048 amidase catalytic site [active] 272123007049 Zn binding residues [ion binding]; other site 272123007050 substrate binding site [chemical binding]; other site 272123007051 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 272123007052 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272123007053 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272123007054 substrate binding pocket [chemical binding]; other site 272123007055 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272123007056 B12 binding site [chemical binding]; other site 272123007057 cobalt ligand [ion binding]; other site 272123007058 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272123007059 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272123007060 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272123007061 substrate binding pocket [chemical binding]; other site 272123007062 membrane-bound complex binding site; other site 272123007063 hinge residues; other site 272123007064 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272123007065 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272123007066 Walker A/P-loop; other site 272123007067 ATP binding site [chemical binding]; other site 272123007068 Q-loop/lid; other site 272123007069 ABC transporter signature motif; other site 272123007070 Walker B; other site 272123007071 D-loop; other site 272123007072 H-loop/switch region; other site 272123007073 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272123007074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123007075 dimer interface [polypeptide binding]; other site 272123007076 conserved gate region; other site 272123007077 ABC-ATPase subunit interface; other site 272123007078 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272123007079 dimer interface [polypeptide binding]; other site 272123007080 [2Fe-2S] cluster binding site [ion binding]; other site 272123007081 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272123007082 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272123007083 dimerization interface [polypeptide binding]; other site 272123007084 DPS ferroxidase diiron center [ion binding]; other site 272123007085 ion pore; other site 272123007086 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272123007087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272123007088 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272123007089 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272123007090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272123007091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272123007092 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272123007093 IMP binding site; other site 272123007094 dimer interface [polypeptide binding]; other site 272123007095 interdomain contacts; other site 272123007096 partial ornithine binding site; other site 272123007097 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 272123007098 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123007099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123007100 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123007101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123007102 DNA binding residues [nucleotide binding] 272123007103 Protein of unknown function (DUF760); Region: DUF760; pfam05542 272123007104 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272123007105 active site 272123007106 8-oxo-dGMP binding site [chemical binding]; other site 272123007107 nudix motif; other site 272123007108 metal binding site [ion binding]; metal-binding site 272123007109 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 272123007110 putative active site [active] 272123007111 FOG: CBS domain [General function prediction only]; Region: COG0517 272123007112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 272123007113 HEAT repeats; Region: HEAT_2; pfam13646 272123007114 HEAT repeats; Region: HEAT_2; pfam13646 272123007115 HEAT repeats; Region: HEAT_2; pfam13646 272123007116 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 272123007117 Caspase domain; Region: Peptidase_C14; pfam00656 272123007118 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 272123007119 ATP-sulfurylase; Region: ATPS; cd00517 272123007120 active site 272123007121 HXXH motif; other site 272123007122 flexible loop; other site 272123007123 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 272123007124 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 272123007125 HNH endonuclease; Region: HNH_2; pfam13391 272123007126 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123007127 putative active site [active] 272123007128 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272123007129 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272123007130 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272123007131 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272123007132 putative substrate binding site [chemical binding]; other site 272123007133 putative ATP binding site [chemical binding]; other site 272123007134 Domain of unknown function DUF39; Region: DUF39; pfam01837 272123007135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123007136 TPR motif; other site 272123007137 binding surface 272123007138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007139 binding surface 272123007140 TPR motif; other site 272123007141 TPR repeat; Region: TPR_11; pfam13414 272123007142 Predicted membrane protein [Function unknown]; Region: COG2119 272123007143 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272123007144 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272123007145 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 272123007146 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 272123007147 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272123007148 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272123007149 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272123007150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007151 Mg2+ binding site [ion binding]; other site 272123007152 G-X-G motif; other site 272123007153 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272123007154 anchoring element; other site 272123007155 dimer interface [polypeptide binding]; other site 272123007156 ATP binding site [chemical binding]; other site 272123007157 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272123007158 active site 272123007159 metal binding site [ion binding]; metal-binding site 272123007160 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123007161 protein-splicing catalytic site; other site 272123007162 thioester formation/cholesterol transfer; other site 272123007163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123007164 non-specific DNA binding site [nucleotide binding]; other site 272123007165 salt bridge; other site 272123007166 sequence-specific DNA binding site [nucleotide binding]; other site 272123007167 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 272123007168 protein-splicing catalytic site; other site 272123007169 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272123007170 active site 272123007171 metal binding site [ion binding]; metal-binding site 272123007172 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272123007173 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 272123007174 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123007175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123007176 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123007177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123007178 DNA binding residues [nucleotide binding] 272123007179 light-harvesting-like protein 3; Provisional; Region: PLN00014 272123007180 DNA gyrase subunit A; Validated; Region: PRK05560 272123007181 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272123007182 CAP-like domain; other site 272123007183 active site 272123007184 primary dimer interface [polypeptide binding]; other site 272123007185 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123007186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123007187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123007188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272123007189 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123007190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007191 active site 272123007192 phosphorylation site [posttranslational modification] 272123007193 intermolecular recognition site; other site 272123007194 dimerization interface [polypeptide binding]; other site 272123007195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007196 binding surface 272123007197 TPR motif; other site 272123007198 TPR repeat; Region: TPR_11; pfam13414 272123007199 TPR repeat; Region: TPR_11; pfam13414 272123007200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007201 binding surface 272123007202 TPR motif; other site 272123007203 TPR repeat; Region: TPR_11; pfam13414 272123007204 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272123007205 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272123007206 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123007207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123007208 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272123007209 FtsX-like permease family; Region: FtsX; pfam02687 272123007210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272123007211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123007212 Walker A/P-loop; other site 272123007213 ATP binding site [chemical binding]; other site 272123007214 Q-loop/lid; other site 272123007215 ABC transporter signature motif; other site 272123007216 Walker B; other site 272123007217 D-loop; other site 272123007218 H-loop/switch region; other site 272123007219 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272123007220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123007221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123007222 CAAX protease self-immunity; Region: Abi; pfam02517 272123007223 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272123007224 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123007225 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123007226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123007227 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272123007228 FtsX-like permease family; Region: FtsX; pfam02687 272123007229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272123007230 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123007231 Walker A/P-loop; other site 272123007232 ATP binding site [chemical binding]; other site 272123007233 Q-loop/lid; other site 272123007234 ABC transporter signature motif; other site 272123007235 Walker B; other site 272123007236 D-loop; other site 272123007237 H-loop/switch region; other site 272123007238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123007239 PAS fold; Region: PAS_3; pfam08447 272123007240 putative active site [active] 272123007241 heme pocket [chemical binding]; other site 272123007242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123007243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123007244 dimer interface [polypeptide binding]; other site 272123007245 phosphorylation site [posttranslational modification] 272123007246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007247 ATP binding site [chemical binding]; other site 272123007248 Mg2+ binding site [ion binding]; other site 272123007249 G-X-G motif; other site 272123007250 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123007251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007252 active site 272123007253 phosphorylation site [posttranslational modification] 272123007254 intermolecular recognition site; other site 272123007255 dimerization interface [polypeptide binding]; other site 272123007256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123007257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007258 active site 272123007259 phosphorylation site [posttranslational modification] 272123007260 intermolecular recognition site; other site 272123007261 dimerization interface [polypeptide binding]; other site 272123007262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123007263 DNA binding residues [nucleotide binding] 272123007264 dimerization interface [polypeptide binding]; other site 272123007265 Response regulator receiver domain; Region: Response_reg; pfam00072 272123007266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007267 active site 272123007268 phosphorylation site [posttranslational modification] 272123007269 intermolecular recognition site; other site 272123007270 dimerization interface [polypeptide binding]; other site 272123007271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007272 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123007273 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123007274 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123007275 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272123007276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123007277 SnoaL-like domain; Region: SnoaL_2; pfam12680 272123007278 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 272123007279 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272123007280 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272123007281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123007282 motif II; other site 272123007283 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 272123007284 hypothetical protein; Provisional; Region: PRK09256 272123007285 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 272123007286 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 272123007287 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272123007288 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272123007289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007290 Walker A/P-loop; other site 272123007291 ATP binding site [chemical binding]; other site 272123007292 Q-loop/lid; other site 272123007293 ABC transporter signature motif; other site 272123007294 Walker B; other site 272123007295 D-loop; other site 272123007296 H-loop/switch region; other site 272123007297 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 272123007298 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272123007299 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272123007300 putative active site [active] 272123007301 putative NTP binding site [chemical binding]; other site 272123007302 putative nucleic acid binding site [nucleotide binding]; other site 272123007303 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272123007304 HNH endonuclease; Region: HNH; pfam01844 272123007305 Uncharacterized protein family, YAP/Alf4/glomulin; Region: Kinetochor_Ybp2; pfam08568 272123007306 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123007307 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 272123007308 Peptidase family M48; Region: Peptidase_M48; pfam01435 272123007309 heat shock protein 90; Provisional; Region: PRK05218 272123007310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007311 ATP binding site [chemical binding]; other site 272123007312 Mg2+ binding site [ion binding]; other site 272123007313 G-X-G motif; other site 272123007314 YcfA-like protein; Region: YcfA; pfam07927 272123007315 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272123007316 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123007317 NB-ARC domain; Region: NB-ARC; pfam00931 272123007318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007319 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123007320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007322 binding surface 272123007323 TPR motif; other site 272123007324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007326 binding surface 272123007327 TPR motif; other site 272123007328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007330 binding surface 272123007331 TPR motif; other site 272123007332 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123007335 binding surface 272123007336 TPR motif; other site 272123007337 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123007338 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123007339 putative active site [active] 272123007340 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272123007341 Clp amino terminal domain; Region: Clp_N; pfam02861 272123007342 Clp amino terminal domain; Region: Clp_N; pfam02861 272123007343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007344 Walker A motif; other site 272123007345 ATP binding site [chemical binding]; other site 272123007346 Walker B motif; other site 272123007347 arginine finger; other site 272123007348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007349 Walker A motif; other site 272123007350 ATP binding site [chemical binding]; other site 272123007351 Walker B motif; other site 272123007352 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272123007353 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123007354 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272123007355 dimer interface [polypeptide binding]; other site 272123007356 active site 272123007357 metal binding site [ion binding]; metal-binding site 272123007358 glutathione binding site [chemical binding]; other site 272123007359 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123007360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123007361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123007362 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272123007363 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123007364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123007365 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123007366 DevC protein; Region: devC; TIGR01185 272123007367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123007368 FtsX-like permease family; Region: FtsX; pfam02687 272123007369 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 272123007370 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123007371 Walker A/P-loop; other site 272123007372 ATP binding site [chemical binding]; other site 272123007373 Q-loop/lid; other site 272123007374 ABC transporter signature motif; other site 272123007375 Walker B; other site 272123007376 D-loop; other site 272123007377 H-loop/switch region; other site 272123007378 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123007379 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123007380 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 272123007381 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272123007382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007383 Walker A motif; other site 272123007384 ATP binding site [chemical binding]; other site 272123007385 Walker B motif; other site 272123007386 arginine finger; other site 272123007387 Peptidase family M41; Region: Peptidase_M41; pfam01434 272123007388 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007389 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123007390 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007391 GAF domain; Region: GAF; pfam01590 272123007392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123007393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272123007394 dimer interface [polypeptide binding]; other site 272123007395 phosphorylation site [posttranslational modification] 272123007396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007397 ATP binding site [chemical binding]; other site 272123007398 Mg2+ binding site [ion binding]; other site 272123007399 G-X-G motif; other site 272123007400 PetN; Region: PetN; cl15376 272123007401 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 272123007402 active site 272123007403 catalytic site [active] 272123007404 substrate binding site [chemical binding]; other site 272123007405 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 272123007406 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 272123007407 Ligand binding site; other site 272123007408 Putative Catalytic site; other site 272123007409 DXD motif; other site 272123007410 Predicted membrane protein [Function unknown]; Region: COG2246 272123007411 GtrA-like protein; Region: GtrA; pfam04138 272123007412 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123007413 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 272123007414 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272123007415 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123007416 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 272123007417 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123007418 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123007419 catalytic residues [active] 272123007420 Predicted membrane protein [Function unknown]; Region: COG4094 272123007421 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 272123007422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272123007423 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272123007424 putative dimerization interface [polypeptide binding]; other site 272123007425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123007426 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272123007427 active site 272123007428 ATP binding site [chemical binding]; other site 272123007429 substrate binding site [chemical binding]; other site 272123007430 activation loop (A-loop); other site 272123007431 PBP superfamily domain; Region: PBP_like_2; pfam12849 272123007432 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 272123007433 putative FMN binding site [chemical binding]; other site 272123007434 PBP superfamily domain; Region: PBP_like_2; cl17296 272123007435 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123007436 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272123007437 putative switch regulator; other site 272123007438 non-specific DNA interactions [nucleotide binding]; other site 272123007439 DNA binding site [nucleotide binding] 272123007440 sequence specific DNA binding site [nucleotide binding]; other site 272123007441 putative cAMP binding site [chemical binding]; other site 272123007442 DALR anticodon binding domain; Region: DALR_1; smart00836 272123007443 anticodon binding site; other site 272123007444 tRNA binding surface [nucleotide binding]; other site 272123007445 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272123007446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123007447 active site 272123007448 motif I; other site 272123007449 motif II; other site 272123007450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123007451 DNA polymerase I; Provisional; Region: PRK05755 272123007452 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272123007453 active site 272123007454 metal binding site 1 [ion binding]; metal-binding site 272123007455 putative 5' ssDNA interaction site; other site 272123007456 metal binding site 3; metal-binding site 272123007457 metal binding site 2 [ion binding]; metal-binding site 272123007458 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272123007459 putative DNA binding site [nucleotide binding]; other site 272123007460 putative metal binding site [ion binding]; other site 272123007461 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272123007462 active site 272123007463 catalytic site [active] 272123007464 substrate binding site [chemical binding]; other site 272123007465 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272123007466 active site 272123007467 DNA binding site [nucleotide binding] 272123007468 catalytic site [active] 272123007469 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007470 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123007471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123007472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123007473 metal binding site [ion binding]; metal-binding site 272123007474 active site 272123007475 I-site; other site 272123007476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007477 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272123007478 Walker A motif; other site 272123007479 ATP binding site [chemical binding]; other site 272123007480 Walker B motif; other site 272123007481 arginine finger; other site 272123007482 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272123007483 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123007484 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 272123007485 FO synthase subunit 2; Reviewed; Region: PRK07360 272123007486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123007487 FeS/SAM binding site; other site 272123007488 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123007489 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 272123007490 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123007491 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123007492 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123007493 structural tetrad; other site 272123007494 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123007495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123007496 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272123007497 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272123007498 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123007499 oligomeric interface; other site 272123007500 putative active site [active] 272123007501 homodimer interface [polypeptide binding]; other site 272123007502 PemK-like protein; Region: PemK; pfam02452 272123007503 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 272123007504 Protein of unknown function DUF91; Region: DUF91; cl00709 272123007505 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 272123007506 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272123007507 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272123007508 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272123007509 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272123007510 ligand binding site [chemical binding]; other site 272123007511 homodimer interface [polypeptide binding]; other site 272123007512 NAD(P) binding site [chemical binding]; other site 272123007513 trimer interface B [polypeptide binding]; other site 272123007514 trimer interface A [polypeptide binding]; other site 272123007515 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 272123007516 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272123007517 ribonuclease P; Reviewed; Region: rnpA; PRK03031 272123007518 Bacterial PH domain; Region: DUF304; pfam03703 272123007519 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 272123007520 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272123007521 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272123007522 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272123007523 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272123007524 G-X-X-G motif; other site 272123007525 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272123007526 RxxxH motif; other site 272123007527 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272123007528 PemK-like protein; Region: PemK; pfam02452 272123007529 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272123007530 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123007531 cofactor binding site; other site 272123007532 DNA binding site [nucleotide binding] 272123007533 substrate interaction site [chemical binding]; other site 272123007534 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123007535 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 272123007536 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272123007537 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 272123007538 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123007539 Ycf46; Provisional; Region: ycf46; CHL00195 272123007540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007541 Walker A motif; other site 272123007542 ATP binding site [chemical binding]; other site 272123007543 Walker B motif; other site 272123007544 arginine finger; other site 272123007545 Bacterial SH3 domain; Region: SH3_3; cl17532 272123007546 PAS fold; Region: PAS_7; pfam12860 272123007547 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123007548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123007549 metal binding site [ion binding]; metal-binding site 272123007550 active site 272123007551 I-site; other site 272123007552 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123007553 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272123007554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007555 Walker A/P-loop; other site 272123007556 ATP binding site [chemical binding]; other site 272123007557 Q-loop/lid; other site 272123007558 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272123007559 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 272123007560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007561 ABC transporter signature motif; other site 272123007562 Walker B; other site 272123007563 D-loop; other site 272123007564 H-loop/switch region; other site 272123007565 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123007566 putative active site [active] 272123007567 Protein of unknown function (DUF456); Region: DUF456; cl01069 272123007568 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 272123007569 Ycf27; Reviewed; Region: orf27; CHL00148 272123007570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007571 active site 272123007572 phosphorylation site [posttranslational modification] 272123007573 intermolecular recognition site; other site 272123007574 dimerization interface [polypeptide binding]; other site 272123007575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123007576 DNA binding site [nucleotide binding] 272123007577 DNA repair protein RadA; Provisional; Region: PRK11823 272123007578 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272123007579 Walker A motif/ATP binding site; other site 272123007580 ATP binding site [chemical binding]; other site 272123007581 Walker B motif; other site 272123007582 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272123007583 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272123007584 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272123007585 NAD binding site [chemical binding]; other site 272123007586 substrate binding site [chemical binding]; other site 272123007587 homodimer interface [polypeptide binding]; other site 272123007588 active site 272123007589 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272123007590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123007591 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123007592 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 272123007593 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272123007594 Sm and related proteins; Region: Sm_like; cl00259 272123007595 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272123007596 putative oligomer interface [polypeptide binding]; other site 272123007597 putative RNA binding site [nucleotide binding]; other site 272123007598 NusA N-terminal domain; Region: NusA_N; pfam08529 272123007599 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272123007600 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272123007601 RNA binding site [nucleotide binding]; other site 272123007602 homodimer interface [polypeptide binding]; other site 272123007603 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272123007604 G-X-X-G motif; other site 272123007605 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272123007606 G-X-X-G motif; other site 272123007607 Protein of unknown function (DUF448); Region: DUF448; pfam04296 272123007608 putative RNA binding cleft [nucleotide binding]; other site 272123007609 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272123007610 translation initiation factor IF-2; Region: IF-2; TIGR00487 272123007611 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272123007612 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272123007613 G1 box; other site 272123007614 putative GEF interaction site [polypeptide binding]; other site 272123007615 GTP/Mg2+ binding site [chemical binding]; other site 272123007616 Switch I region; other site 272123007617 G2 box; other site 272123007618 G3 box; other site 272123007619 Switch II region; other site 272123007620 G4 box; other site 272123007621 G5 box; other site 272123007622 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272123007623 Translation-initiation factor 2; Region: IF-2; pfam11987 272123007624 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272123007625 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 272123007626 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 272123007627 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 272123007628 S-layer homology domain; Region: SLH; pfam00395 272123007629 S-layer homology domain; Region: SLH; pfam00395 272123007630 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 272123007631 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 272123007632 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272123007633 DNA binding residues [nucleotide binding] 272123007634 putative dimer interface [polypeptide binding]; other site 272123007635 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123007636 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123007637 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123007638 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 272123007639 ADP-ribose binding site [chemical binding]; other site 272123007640 TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF11; cl02176 272123007641 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272123007642 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272123007643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123007644 ATP binding site [chemical binding]; other site 272123007645 putative Mg++ binding site [ion binding]; other site 272123007646 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 272123007647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123007648 non-specific DNA binding site [nucleotide binding]; other site 272123007649 salt bridge; other site 272123007650 sequence-specific DNA binding site [nucleotide binding]; other site 272123007651 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123007652 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123007653 Helix-turn-helix domain; Region: HTH_28; pfam13518 272123007654 Winged helix-turn helix; Region: HTH_29; pfam13551 272123007655 Integrase core domain; Region: rve; pfam00665 272123007656 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 272123007657 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 272123007658 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 272123007659 OstA-like protein; Region: OstA; cl00844 272123007660 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272123007661 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 272123007662 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123007663 putative active site [active] 272123007664 Lamin Tail Domain; Region: LTD; pfam00932 272123007665 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 272123007666 generic binding surface I; other site 272123007667 generic binding surface II; other site 272123007668 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 272123007669 putative active site [active] 272123007670 putative catalytic site [active] 272123007671 putative Mg binding site IVb [ion binding]; other site 272123007672 putative DNA binding site [nucleotide binding]; other site 272123007673 putative phosphate binding site [ion binding]; other site 272123007674 putative Mg binding site IVa [ion binding]; other site 272123007675 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123007676 Ca2+ binding site [ion binding]; other site 272123007677 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272123007678 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272123007679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123007680 FeS/SAM binding site; other site 272123007681 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 272123007682 Uncharacterized conserved protein [Function unknown]; Region: COG4715 272123007683 SWIM zinc finger; Region: SWIM; pfam04434 272123007684 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272123007685 TIGR02646 family protein; Region: TIGR02646 272123007686 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 272123007687 AAA domain; Region: AAA_21; pfam13304 272123007688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007689 Q-loop/lid; other site 272123007690 ABC transporter signature motif; other site 272123007691 Walker B; other site 272123007692 D-loop; other site 272123007693 H-loop/switch region; other site 272123007694 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 272123007695 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123007696 active site 272123007697 metal binding site [ion binding]; metal-binding site 272123007698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123007699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007700 active site 272123007701 phosphorylation site [posttranslational modification] 272123007702 intermolecular recognition site; other site 272123007703 dimerization interface [polypeptide binding]; other site 272123007704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123007705 DNA binding site [nucleotide binding] 272123007706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123007707 dimer interface [polypeptide binding]; other site 272123007708 phosphorylation site [posttranslational modification] 272123007709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007710 ATP binding site [chemical binding]; other site 272123007711 Mg2+ binding site [ion binding]; other site 272123007712 G-X-G motif; other site 272123007713 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123007714 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123007715 dimer interface [polypeptide binding]; other site 272123007716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123007717 catalytic residue [active] 272123007718 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272123007719 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 272123007720 putative active site cavity [active] 272123007721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123007723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123007724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123007725 dimer interface [polypeptide binding]; other site 272123007726 phosphorylation site [posttranslational modification] 272123007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007728 ATP binding site [chemical binding]; other site 272123007729 Mg2+ binding site [ion binding]; other site 272123007730 G-X-G motif; other site 272123007731 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 272123007732 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123007733 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123007734 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123007735 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272123007736 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123007737 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123007738 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272123007739 metal binding site 2 [ion binding]; metal-binding site 272123007740 putative DNA binding helix; other site 272123007741 metal binding site 1 [ion binding]; metal-binding site 272123007742 dimer interface [polypeptide binding]; other site 272123007743 structural Zn2+ binding site [ion binding]; other site 272123007744 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 272123007745 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123007746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123007747 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123007748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123007749 DNA binding residues [nucleotide binding] 272123007750 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 272123007751 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272123007752 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272123007753 lipoyl synthase; Provisional; Region: PRK05481 272123007754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123007755 FeS/SAM binding site; other site 272123007756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123007757 dimerization interface [polypeptide binding]; other site 272123007758 PAS domain S-box; Region: sensory_box; TIGR00229 272123007759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123007760 putative active site [active] 272123007761 heme pocket [chemical binding]; other site 272123007762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123007763 PAS fold; Region: PAS_3; pfam08447 272123007764 putative active site [active] 272123007765 heme pocket [chemical binding]; other site 272123007766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123007767 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123007768 putative active site [active] 272123007769 heme pocket [chemical binding]; other site 272123007770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123007771 putative active site [active] 272123007772 heme pocket [chemical binding]; other site 272123007773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123007774 dimer interface [polypeptide binding]; other site 272123007775 phosphorylation site [posttranslational modification] 272123007776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123007777 ATP binding site [chemical binding]; other site 272123007778 Mg2+ binding site [ion binding]; other site 272123007779 G-X-G motif; other site 272123007780 Response regulator receiver domain; Region: Response_reg; pfam00072 272123007781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123007782 active site 272123007783 phosphorylation site [posttranslational modification] 272123007784 intermolecular recognition site; other site 272123007785 dimerization interface [polypeptide binding]; other site 272123007786 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 272123007787 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123007788 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123007789 Hexamer interface [polypeptide binding]; other site 272123007790 Hexagonal pore residue; other site 272123007791 aspartate aminotransferase; Provisional; Region: PRK05957 272123007792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123007793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123007794 homodimer interface [polypeptide binding]; other site 272123007795 catalytic residue [active] 272123007796 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 272123007797 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272123007798 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272123007799 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272123007800 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272123007801 MgtC family; Region: MgtC; pfam02308 272123007802 recombination protein F; Reviewed; Region: recF; PRK00064 272123007803 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272123007804 Walker A/P-loop; other site 272123007805 ATP binding site [chemical binding]; other site 272123007806 Q-loop/lid; other site 272123007807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123007808 ABC transporter signature motif; other site 272123007809 Walker B; other site 272123007810 D-loop; other site 272123007811 H-loop/switch region; other site 272123007812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272123007813 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272123007814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123007815 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272123007816 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272123007817 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272123007818 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272123007819 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272123007820 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272123007821 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272123007822 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 272123007823 active site 272123007824 substrate binding site [chemical binding]; other site 272123007825 metal binding site [ion binding]; metal-binding site 272123007826 Divergent AAA domain; Region: AAA_4; pfam04326 272123007827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123007828 NACHT domain; Region: NACHT; pfam05729 272123007829 Walker A motif; other site 272123007830 ATP binding site [chemical binding]; other site 272123007831 Walker B motif; other site 272123007832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 272123007833 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 272123007834 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123007835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123007836 Predicted membrane protein [Function unknown]; Region: COG4330 272123007837 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272123007838 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272123007839 Walker A/P-loop; other site 272123007840 ATP binding site [chemical binding]; other site 272123007841 Q-loop/lid; other site 272123007842 ABC transporter signature motif; other site 272123007843 Walker B; other site 272123007844 D-loop; other site 272123007845 H-loop/switch region; other site 272123007846 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272123007847 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 272123007848 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 272123007849 PDGLE domain; Region: PDGLE; pfam13190 272123007850 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123007851 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123007852 active site 272123007853 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 272123007854 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272123007855 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272123007856 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272123007857 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 272123007858 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272123007859 Ferritin-like domain; Region: Ferritin; pfam00210 272123007860 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272123007861 dinuclear metal binding motif [ion binding]; other site 272123007862 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 272123007863 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272123007864 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 272123007865 putative ligand binding site [chemical binding]; other site 272123007866 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 272123007867 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272123007868 GTP binding site; other site 272123007869 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123007870 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 272123007871 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 272123007872 catalytic residues [active] 272123007873 Clp protease; Region: CLP_protease; pfam00574 272123007874 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272123007875 oligomer interface [polypeptide binding]; other site 272123007876 active site residues [active] 272123007877 Exoribonuclease R [Transcription]; Region: VacB; COG0557 272123007878 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272123007879 RNB domain; Region: RNB; pfam00773 272123007880 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272123007881 RNA binding site [nucleotide binding]; other site 272123007882 aromatic acid decarboxylase; Validated; Region: PRK05920 272123007883 Flavoprotein; Region: Flavoprotein; pfam02441 272123007884 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 272123007885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272123007886 AAA ATPase domain; Region: AAA_16; pfam13191 272123007887 shikimate kinase; Reviewed; Region: aroK; PRK00131 272123007888 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272123007889 ADP binding site [chemical binding]; other site 272123007890 magnesium binding site [ion binding]; other site 272123007891 putative shikimate binding site; other site 272123007892 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272123007893 feedback inhibition sensing region; other site 272123007894 homohexameric interface [polypeptide binding]; other site 272123007895 nucleotide binding site [chemical binding]; other site 272123007896 N-acetyl-L-glutamate binding site [chemical binding]; other site 272123007897 tetratricopeptide repeat protein; Provisional; Region: PRK11788 272123007898 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 272123007899 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 272123007900 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272123007901 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 272123007902 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123007903 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123007904 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272123007905 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272123007906 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 272123007907 active site 272123007908 Substrate binding site; other site 272123007909 Mg++ binding site; other site 272123007910 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272123007911 putative trimer interface [polypeptide binding]; other site 272123007912 putative CoA binding site [chemical binding]; other site 272123007913 arginine decarboxylase; Provisional; Region: PRK05354 272123007914 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 272123007915 dimer interface [polypeptide binding]; other site 272123007916 active site 272123007917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272123007918 catalytic residues [active] 272123007919 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 272123007920 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272123007921 active site 272123007922 multimer interface [polypeptide binding]; other site 272123007923 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272123007924 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272123007925 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272123007926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 272123007927 acetyl-CoA synthetase; Provisional; Region: PRK00174 272123007928 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 272123007929 active site 272123007930 CoA binding site [chemical binding]; other site 272123007931 acyl-activating enzyme (AAE) consensus motif; other site 272123007932 AMP binding site [chemical binding]; other site 272123007933 acetate binding site [chemical binding]; other site 272123007934 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123007935 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272123007936 active site 272123007937 metal binding site [ion binding]; metal-binding site 272123007938 Z1 domain; Region: Z1; pfam10593 272123007939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123007940 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123007941 active site 272123007942 catalytic tetrad [active] 272123007943 cytochrome c6; Provisional; Region: PRK13697 272123007944 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272123007945 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123007946 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272123007947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123007948 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272123007949 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 272123007950 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 272123007951 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 272123007952 hypothetical protein; Provisional; Region: PRK07377 272123007953 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 272123007954 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 272123007955 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123007956 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 272123007957 AAA ATPase domain; Region: AAA_16; pfam13191 272123007958 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123007959 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272123007960 substrate binding pocket [chemical binding]; other site 272123007961 membrane-bound complex binding site; other site 272123007962 hinge residues; other site 272123007963 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272123007964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123007965 dimer interface [polypeptide binding]; other site 272123007966 conserved gate region; other site 272123007967 putative PBP binding loops; other site 272123007968 ABC-ATPase subunit interface; other site 272123007969 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272123007970 active site 272123007971 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123007972 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123007973 phosphopeptide binding site; other site 272123007974 PAS domain S-box; Region: sensory_box; TIGR00229 272123007975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123007976 GAF domain; Region: GAF; pfam01590 272123007977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123007978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123007979 metal binding site [ion binding]; metal-binding site 272123007980 active site 272123007981 I-site; other site 272123007982 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123007983 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 272123007984 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 272123007985 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123007986 catalytic residue [active] 272123007987 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272123007988 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 272123007989 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123007990 putative C-terminal domain interface [polypeptide binding]; other site 272123007991 putative GSH binding site (G-site) [chemical binding]; other site 272123007992 putative dimer interface [polypeptide binding]; other site 272123007993 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 272123007994 putative N-terminal domain interface [polypeptide binding]; other site 272123007995 putative dimer interface [polypeptide binding]; other site 272123007996 putative substrate binding pocket (H-site) [chemical binding]; other site 272123007997 DDE superfamily endonuclease; Region: DDE_5; cl17874 272123007998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123007999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123008000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272123008001 Coenzyme A binding pocket [chemical binding]; other site 272123008002 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 272123008003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123008004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008005 binding surface 272123008006 TPR motif; other site 272123008007 TPR repeat; Region: TPR_11; pfam13414 272123008008 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123008009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008010 binding surface 272123008011 TPR motif; other site 272123008012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008013 binding surface 272123008014 TPR motif; other site 272123008015 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123008016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008017 binding surface 272123008018 TPR motif; other site 272123008019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008020 binding surface 272123008021 TPR motif; other site 272123008022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008023 binding surface 272123008024 TPR motif; other site 272123008025 TPR repeat; Region: TPR_11; pfam13414 272123008026 CHAT domain; Region: CHAT; pfam12770 272123008027 XisI protein; Region: XisI; pfam08869 272123008028 XisH protein; Region: XisH; pfam08814 272123008029 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 272123008030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272123008031 active site 272123008032 nucleotide binding site [chemical binding]; other site 272123008033 HIGH motif; other site 272123008034 KMSKS motif; other site 272123008035 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 272123008036 proposed catalytic triad [active] 272123008037 active site nucleophile [active] 272123008038 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272123008039 MutS domain I; Region: MutS_I; pfam01624 272123008040 MutS domain II; Region: MutS_II; pfam05188 272123008041 MutS domain III; Region: MutS_III; pfam05192 272123008042 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272123008043 Walker A/P-loop; other site 272123008044 ATP binding site [chemical binding]; other site 272123008045 Q-loop/lid; other site 272123008046 ABC transporter signature motif; other site 272123008047 Walker B; other site 272123008048 D-loop; other site 272123008049 H-loop/switch region; other site 272123008050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123008051 S-adenosylmethionine binding site [chemical binding]; other site 272123008052 Condensation domain; Region: Condensation; pfam00668 272123008053 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123008054 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 272123008055 acyl-activating enzyme (AAE) consensus motif; other site 272123008056 AMP binding site [chemical binding]; other site 272123008057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123008058 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272123008059 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123008060 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123008061 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 272123008062 Transglycosylase; Region: Transgly; pfam00912 272123008063 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272123008064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272123008065 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272123008066 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272123008067 active site 272123008068 HIGH motif; other site 272123008069 dimer interface [polypeptide binding]; other site 272123008070 KMSKS motif; other site 272123008071 S4 RNA-binding domain; Region: S4; smart00363 272123008072 RNA binding surface [nucleotide binding]; other site 272123008073 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272123008074 active site 272123008075 dimer interface [polypeptide binding]; other site 272123008076 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272123008077 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272123008078 MOSC domain; Region: MOSC; pfam03473 272123008079 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123008080 putative active site [active] 272123008081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123008082 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123008083 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272123008084 Fe-S cluster binding site [ion binding]; other site 272123008085 active site 272123008086 Helix-turn-helix domain; Region: HTH_25; pfam13413 272123008087 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272123008088 Helix-turn-helix domain; Region: HTH_25; pfam13413 272123008089 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272123008090 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272123008091 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272123008092 Predicted transcriptional regulators [Transcription]; Region: COG1733 272123008093 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272123008094 short chain dehydrogenase; Provisional; Region: PRK06172 272123008095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123008096 NAD(P) binding site [chemical binding]; other site 272123008097 active site 272123008098 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 272123008099 classical (c) SDRs; Region: SDR_c; cd05233 272123008100 NAD(P) binding site [chemical binding]; other site 272123008101 active site 272123008102 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 272123008103 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 272123008104 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272123008105 generic binding surface I; other site 272123008106 generic binding surface II; other site 272123008107 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 272123008108 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272123008109 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272123008110 active site 272123008111 trimer interface [polypeptide binding]; other site 272123008112 allosteric site; other site 272123008113 active site lid [active] 272123008114 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272123008115 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 272123008116 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123008117 Walker A/P-loop; other site 272123008118 ATP binding site [chemical binding]; other site 272123008119 Q-loop/lid; other site 272123008120 ABC transporter signature motif; other site 272123008121 Walker B; other site 272123008122 D-loop; other site 272123008123 H-loop/switch region; other site 272123008124 DevC protein; Region: devC; TIGR01185 272123008125 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123008126 FtsX-like permease family; Region: FtsX; pfam02687 272123008127 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123008128 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123008129 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 272123008130 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123008131 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272123008132 active site 272123008133 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272123008134 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123008135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123008136 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123008137 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272123008138 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272123008139 putative NADP binding site [chemical binding]; other site 272123008140 active site 272123008141 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 272123008142 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272123008143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123008144 active site 272123008145 Acyl transferase domain; Region: Acyl_transf_1; cl08282 272123008146 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 272123008147 FMN binding site [chemical binding]; other site 272123008148 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272123008149 substrate binding site [chemical binding]; other site 272123008150 putative catalytic residue [active] 272123008151 acyltransferase PapA5; Provisional; Region: PRK09294 272123008152 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 272123008153 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123008154 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123008155 catalytic loop [active] 272123008156 iron binding site [ion binding]; other site 272123008157 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123008158 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123008159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123008160 S-adenosylmethionine binding site [chemical binding]; other site 272123008161 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 272123008162 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272123008163 dimer interface [polypeptide binding]; other site 272123008164 active site 272123008165 Beta-propeller repeat; Region: SBBP; pfam06739 272123008166 Beta-propeller repeat; Region: SBBP; pfam06739 272123008167 Beta-propeller repeat; Region: SBBP; pfam06739 272123008168 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123008169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123008170 NAD(P) binding site [chemical binding]; other site 272123008171 active site 272123008172 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123008173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123008174 S-adenosylmethionine binding site [chemical binding]; other site 272123008175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 272123008176 conserved repeat domain; Region: B_ant_repeat; TIGR01451 272123008177 conserved repeat domain; Region: B_ant_repeat; TIGR01451 272123008178 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 272123008179 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272123008180 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272123008181 catalytic residue [active] 272123008182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272123008183 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272123008184 pyrroline-5-carboxylate reductase; Region: PLN02688 272123008185 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123008186 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 272123008187 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123008188 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123008189 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123008190 oligomeric interface; other site 272123008191 putative active site [active] 272123008192 homodimer interface [polypeptide binding]; other site 272123008193 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 272123008194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123008195 ATP binding site [chemical binding]; other site 272123008196 putative Mg++ binding site [ion binding]; other site 272123008197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123008198 nucleotide binding region [chemical binding]; other site 272123008199 ATP-binding site [chemical binding]; other site 272123008200 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 272123008201 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272123008202 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272123008203 [2Fe-2S] cluster binding site [ion binding]; other site 272123008204 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 272123008205 DNA binding residues [nucleotide binding] 272123008206 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 272123008207 dimer interface [polypeptide binding]; other site 272123008208 metal binding site [ion binding]; metal-binding site 272123008209 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 272123008210 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272123008211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272123008212 metal-binding site [ion binding] 272123008213 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123008214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123008215 motif II; other site 272123008216 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 272123008217 metal-binding site [ion binding] 272123008218 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 272123008219 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 272123008220 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 272123008221 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 272123008222 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 272123008223 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272123008224 FMN binding site [chemical binding]; other site 272123008225 active site 272123008226 catalytic residues [active] 272123008227 substrate binding site [chemical binding]; other site 272123008228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123008229 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123008230 Predicted ATPase [General function prediction only]; Region: COG4637 272123008231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123008232 Walker A/P-loop; other site 272123008233 ATP binding site [chemical binding]; other site 272123008234 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 272123008235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123008237 dimer interface [polypeptide binding]; other site 272123008238 phosphorylation site [posttranslational modification] 272123008239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008240 ATP binding site [chemical binding]; other site 272123008241 Mg2+ binding site [ion binding]; other site 272123008242 G-X-G motif; other site 272123008243 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123008244 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272123008245 putative C-terminal domain interface [polypeptide binding]; other site 272123008246 putative GSH binding site (G-site) [chemical binding]; other site 272123008247 putative dimer interface [polypeptide binding]; other site 272123008248 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272123008249 N-terminal domain interface [polypeptide binding]; other site 272123008250 dimer interface [polypeptide binding]; other site 272123008251 substrate binding pocket (H-site) [chemical binding]; other site 272123008252 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272123008253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123008254 dimer interface [polypeptide binding]; other site 272123008255 conserved gate region; other site 272123008256 putative PBP binding loops; other site 272123008257 ABC-ATPase subunit interface; other site 272123008258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123008259 Walker A/P-loop; other site 272123008260 ATP binding site [chemical binding]; other site 272123008261 ABC transporter; Region: ABC_tran; pfam00005 272123008262 Q-loop/lid; other site 272123008263 ABC transporter signature motif; other site 272123008264 Walker B; other site 272123008265 D-loop; other site 272123008266 H-loop/switch region; other site 272123008267 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 272123008268 MltA specific insert domain; Region: MltA; pfam03562 272123008269 3D domain; Region: 3D; pfam06725 272123008270 proton extrusion protein PcxA; Provisional; Region: PRK02507 272123008271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123008272 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272123008273 FeS/SAM binding site; other site 272123008274 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 272123008275 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 272123008276 dihydroorotase; Provisional; Region: PRK07369 272123008277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272123008278 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272123008279 active site 272123008280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123008281 catalytic core [active] 272123008282 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123008283 catalytic core [active] 272123008284 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 272123008285 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 272123008286 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 272123008287 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008288 putative active site [active] 272123008289 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 272123008290 Protein of unknown function (DUF790); Region: DUF790; pfam05626 272123008291 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272123008292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123008293 ATP binding site [chemical binding]; other site 272123008294 putative Mg++ binding site [ion binding]; other site 272123008295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123008296 nucleotide binding region [chemical binding]; other site 272123008297 ATP-binding site [chemical binding]; other site 272123008298 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 272123008299 cyclase homology domain; Region: CHD; cd07302 272123008300 nucleotidyl binding site; other site 272123008301 metal binding site [ion binding]; metal-binding site 272123008302 dimer interface [polypeptide binding]; other site 272123008303 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272123008304 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123008305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123008306 putative active site [active] 272123008307 heme pocket [chemical binding]; other site 272123008308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123008309 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123008310 putative active site [active] 272123008311 heme pocket [chemical binding]; other site 272123008312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123008313 putative active site [active] 272123008314 heme pocket [chemical binding]; other site 272123008315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123008316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008317 dimer interface [polypeptide binding]; other site 272123008318 phosphorylation site [posttranslational modification] 272123008319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008320 ATP binding site [chemical binding]; other site 272123008321 Mg2+ binding site [ion binding]; other site 272123008322 G-X-G motif; other site 272123008323 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008325 active site 272123008326 phosphorylation site [posttranslational modification] 272123008327 intermolecular recognition site; other site 272123008328 dimerization interface [polypeptide binding]; other site 272123008329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123008330 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123008331 active site 272123008332 ATP binding site [chemical binding]; other site 272123008333 substrate binding site [chemical binding]; other site 272123008334 activation loop (A-loop); other site 272123008335 methionine sulfoxide reductase A; Provisional; Region: PRK00058 272123008336 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272123008337 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 272123008338 putative NAD(P) binding site [chemical binding]; other site 272123008339 homodimer interface [polypeptide binding]; other site 272123008340 homotetramer interface [polypeptide binding]; other site 272123008341 active site 272123008342 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272123008343 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 272123008344 oligomer interface [polypeptide binding]; other site 272123008345 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 272123008346 active site 272123008347 dinuclear metal binding site [ion binding]; other site 272123008348 dimerization interface [polypeptide binding]; other site 272123008349 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272123008350 structural tetrad; other site 272123008351 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123008352 Membrane protein of unknown function; Region: DUF360; cl00850 272123008353 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272123008354 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272123008355 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272123008356 glucose-1-dehydrogenase; Provisional; Region: PRK08936 272123008357 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 272123008358 NAD binding site [chemical binding]; other site 272123008359 homodimer interface [polypeptide binding]; other site 272123008360 active site 272123008361 aspartate kinase; Provisional; Region: PRK07431 272123008362 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272123008363 putative nucleotide binding site [chemical binding]; other site 272123008364 putative catalytic residues [active] 272123008365 putative Mg ion binding site [ion binding]; other site 272123008366 putative aspartate binding site [chemical binding]; other site 272123008367 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272123008368 putative allosteric regulatory site; other site 272123008369 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 272123008370 putative allosteric regulatory residue; other site 272123008371 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272123008372 putative allosteric regulatory site; other site 272123008373 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 272123008374 putative allosteric regulatory residue; other site 272123008375 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272123008376 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272123008377 Walker A/P-loop; other site 272123008378 ATP binding site [chemical binding]; other site 272123008379 Q-loop/lid; other site 272123008380 ABC transporter signature motif; other site 272123008381 Walker B; other site 272123008382 D-loop; other site 272123008383 H-loop/switch region; other site 272123008384 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272123008385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123008386 dimer interface [polypeptide binding]; other site 272123008387 conserved gate region; other site 272123008388 putative PBP binding loops; other site 272123008389 ABC-ATPase subunit interface; other site 272123008390 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272123008391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123008392 dimer interface [polypeptide binding]; other site 272123008393 conserved gate region; other site 272123008394 putative PBP binding loops; other site 272123008395 ABC-ATPase subunit interface; other site 272123008396 PBP superfamily domain; Region: PBP_like_2; cl17296 272123008397 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 272123008398 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272123008399 classical (c) SDRs; Region: SDR_c; cd05233 272123008400 NAD(P) binding site [chemical binding]; other site 272123008401 active site 272123008402 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123008403 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 272123008404 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 272123008405 putative NAD(P) binding site [chemical binding]; other site 272123008406 active site 272123008407 putative substrate binding site [chemical binding]; other site 272123008408 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 272123008409 FMN binding site [chemical binding]; other site 272123008410 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272123008411 substrate binding site [chemical binding]; other site 272123008412 putative catalytic residue [active] 272123008413 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123008414 active site 272123008415 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272123008416 Acyl transferase domain; Region: Acyl_transf_1; cl08282 272123008417 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123008418 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272123008419 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123008420 active site 272123008421 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272123008422 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272123008423 putative NADP binding site [chemical binding]; other site 272123008424 active site 272123008425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123008426 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272123008427 active site 272123008428 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272123008429 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123008430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123008431 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123008432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123008433 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123008434 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123008435 DevC protein; Region: devC; TIGR01185 272123008436 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123008437 FtsX-like permease family; Region: FtsX; pfam02687 272123008438 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123008439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123008440 NAD(P) binding site [chemical binding]; other site 272123008441 active site 272123008442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 272123008443 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272123008444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123008445 active site 272123008446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123008447 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 272123008448 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272123008449 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272123008450 Walker A/P-loop; other site 272123008451 ATP binding site [chemical binding]; other site 272123008452 Q-loop/lid; other site 272123008453 ABC transporter signature motif; other site 272123008454 Walker B; other site 272123008455 D-loop; other site 272123008456 H-loop/switch region; other site 272123008457 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 272123008458 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272123008459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123008460 dimer interface [polypeptide binding]; other site 272123008461 conserved gate region; other site 272123008462 ABC-ATPase subunit interface; other site 272123008463 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 272123008464 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 272123008465 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272123008466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123008467 Coenzyme A binding pocket [chemical binding]; other site 272123008468 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 272123008469 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 272123008470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272123008471 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 272123008472 active site 272123008473 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 272123008474 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 272123008475 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272123008476 Walker A/P-loop; other site 272123008477 ATP binding site [chemical binding]; other site 272123008478 Q-loop/lid; other site 272123008479 ABC transporter signature motif; other site 272123008480 Walker B; other site 272123008481 D-loop; other site 272123008482 H-loop/switch region; other site 272123008483 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272123008484 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 272123008485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123008486 Walker A/P-loop; other site 272123008487 ATP binding site [chemical binding]; other site 272123008488 Q-loop/lid; other site 272123008489 ABC transporter signature motif; other site 272123008490 Walker B; other site 272123008491 D-loop; other site 272123008492 H-loop/switch region; other site 272123008493 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008495 active site 272123008496 phosphorylation site [posttranslational modification] 272123008497 intermolecular recognition site; other site 272123008498 dimerization interface [polypeptide binding]; other site 272123008499 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008501 active site 272123008502 phosphorylation site [posttranslational modification] 272123008503 intermolecular recognition site; other site 272123008504 dimerization interface [polypeptide binding]; other site 272123008505 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272123008506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008507 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008509 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008510 GAF domain; Region: GAF_2; pfam13185 272123008511 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008512 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008513 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008515 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008516 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008517 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272123008519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272123008520 dimer interface [polypeptide binding]; other site 272123008521 putative CheW interface [polypeptide binding]; other site 272123008522 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123008523 putative binding surface; other site 272123008524 active site 272123008525 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272123008526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008527 ATP binding site [chemical binding]; other site 272123008528 Mg2+ binding site [ion binding]; other site 272123008529 G-X-G motif; other site 272123008530 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272123008531 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123008532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008533 active site 272123008534 phosphorylation site [posttranslational modification] 272123008535 intermolecular recognition site; other site 272123008536 dimerization interface [polypeptide binding]; other site 272123008537 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272123008538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123008539 dimer interface [polypeptide binding]; other site 272123008540 conserved gate region; other site 272123008541 putative PBP binding loops; other site 272123008542 ABC-ATPase subunit interface; other site 272123008543 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272123008544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272123008545 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272123008546 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272123008547 Walker A/P-loop; other site 272123008548 ATP binding site [chemical binding]; other site 272123008549 Q-loop/lid; other site 272123008550 ABC transporter signature motif; other site 272123008551 Walker B; other site 272123008552 D-loop; other site 272123008553 H-loop/switch region; other site 272123008554 TOBE domain; Region: TOBE_2; pfam08402 272123008555 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272123008556 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272123008557 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272123008558 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272123008559 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272123008560 Predicted permeases [General function prediction only]; Region: COG0679 272123008561 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 272123008562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123008563 active site 272123008564 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272123008565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123008566 putative substrate translocation pore; other site 272123008567 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 272123008568 Double zinc ribbon; Region: DZR; pfam12773 272123008569 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 272123008570 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272123008571 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 272123008572 Chromate transporter; Region: Chromate_transp; pfam02417 272123008573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123008574 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123008575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123008576 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123008577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123008578 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 272123008579 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 272123008580 putative active site [active] 272123008581 catalytic site [active] 272123008582 putative metal binding site [ion binding]; other site 272123008583 photosystem I subunit VII; Region: psaC; CHL00065 272123008584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272123008585 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272123008586 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272123008587 glutaminase active site [active] 272123008588 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272123008589 dimer interface [polypeptide binding]; other site 272123008590 active site 272123008591 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272123008592 dimer interface [polypeptide binding]; other site 272123008593 active site 272123008594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123008595 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 272123008596 putative ADP-binding pocket [chemical binding]; other site 272123008597 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123008598 active site 272123008599 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272123008600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123008601 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272123008602 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123008603 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272123008604 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272123008605 Walker A/P-loop; other site 272123008606 ATP binding site [chemical binding]; other site 272123008607 Q-loop/lid; other site 272123008608 ABC transporter signature motif; other site 272123008609 Walker B; other site 272123008610 D-loop; other site 272123008611 H-loop/switch region; other site 272123008612 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272123008613 putative carbohydrate binding site [chemical binding]; other site 272123008614 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123008615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123008616 active site 272123008617 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123008618 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123008619 active site 272123008620 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 272123008621 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272123008622 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272123008623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123008624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272123008625 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 272123008626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008627 binding surface 272123008628 TPR motif; other site 272123008629 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272123008630 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272123008631 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272123008632 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123008633 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272123008634 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 272123008635 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272123008636 Clp amino terminal domain; Region: Clp_N; pfam02861 272123008637 Clp amino terminal domain; Region: Clp_N; pfam02861 272123008638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123008639 Walker A motif; other site 272123008640 ATP binding site [chemical binding]; other site 272123008641 Walker B motif; other site 272123008642 arginine finger; other site 272123008643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123008644 Walker A motif; other site 272123008645 ATP binding site [chemical binding]; other site 272123008646 Walker B motif; other site 272123008647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272123008648 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 272123008649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272123008650 hydrophobic ligand binding site; other site 272123008651 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 272123008652 flavoprotein, HI0933 family; Region: TIGR00275 272123008653 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272123008654 putative active site [active] 272123008655 homotetrameric interface [polypeptide binding]; other site 272123008656 metal binding site [ion binding]; metal-binding site 272123008657 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 272123008658 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272123008659 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272123008660 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272123008661 trimer interface [polypeptide binding]; other site 272123008662 active site 272123008663 UDP-GlcNAc binding site [chemical binding]; other site 272123008664 lipid binding site [chemical binding]; lipid-binding site 272123008665 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 272123008666 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123008667 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123008668 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123008669 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123008670 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 272123008671 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272123008672 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272123008673 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272123008674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123008675 dimerization interface [polypeptide binding]; other site 272123008676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008677 dimer interface [polypeptide binding]; other site 272123008678 phosphorylation site [posttranslational modification] 272123008679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008680 ATP binding site [chemical binding]; other site 272123008681 Mg2+ binding site [ion binding]; other site 272123008682 G-X-G motif; other site 272123008683 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 272123008684 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 272123008685 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123008686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123008687 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272123008688 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272123008689 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123008690 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123008691 active site 272123008692 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123008693 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123008694 active site 272123008695 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 272123008696 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 272123008697 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123008698 anti sigma factor interaction site; other site 272123008699 regulatory phosphorylation site [posttranslational modification]; other site 272123008700 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272123008701 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272123008702 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272123008703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123008704 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123008705 anti sigma factor interaction site; other site 272123008706 regulatory phosphorylation site [posttranslational modification]; other site 272123008707 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008709 active site 272123008710 phosphorylation site [posttranslational modification] 272123008711 intermolecular recognition site; other site 272123008712 dimerization interface [polypeptide binding]; other site 272123008713 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272123008714 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272123008715 Heme NO binding associated; Region: HNOBA; pfam07701 272123008716 PAS domain S-box; Region: sensory_box; TIGR00229 272123008717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123008718 PAS fold; Region: PAS_3; pfam08447 272123008719 putative active site [active] 272123008720 heme pocket [chemical binding]; other site 272123008721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123008723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008724 dimer interface [polypeptide binding]; other site 272123008725 phosphorylation site [posttranslational modification] 272123008726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008727 ATP binding site [chemical binding]; other site 272123008728 Mg2+ binding site [ion binding]; other site 272123008729 G-X-G motif; other site 272123008730 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008732 active site 272123008733 phosphorylation site [posttranslational modification] 272123008734 intermolecular recognition site; other site 272123008735 dimerization interface [polypeptide binding]; other site 272123008736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008737 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008738 active site 272123008739 phosphorylation site [posttranslational modification] 272123008740 intermolecular recognition site; other site 272123008741 dimerization interface [polypeptide binding]; other site 272123008742 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123008743 putative binding surface; other site 272123008744 active site 272123008745 Heme NO binding; Region: HNOB; pfam07700 272123008746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123008747 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123008748 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123008749 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123008750 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 272123008751 nudix motif; other site 272123008752 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272123008753 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 272123008754 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272123008755 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272123008756 homodimer interface [polypeptide binding]; other site 272123008757 NADP binding site [chemical binding]; other site 272123008758 substrate binding site [chemical binding]; other site 272123008759 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272123008760 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272123008761 substrate binding pocket [chemical binding]; other site 272123008762 chain length determination region; other site 272123008763 substrate-Mg2+ binding site; other site 272123008764 catalytic residues [active] 272123008765 aspartate-rich region 1; other site 272123008766 active site lid residues [active] 272123008767 aspartate-rich region 2; other site 272123008768 Divergent PAP2 family; Region: DUF212; pfam02681 272123008769 oxidoreductase; Region: PLN02835 272123008770 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 272123008771 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272123008772 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 272123008773 active site 272123008774 hydrophilic channel; other site 272123008775 dimerization interface [polypeptide binding]; other site 272123008776 catalytic residues [active] 272123008777 active site lid [active] 272123008778 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008779 putative active site [active] 272123008780 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008781 putative active site [active] 272123008782 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 272123008783 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 272123008784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123008785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123008786 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272123008787 Walker A/P-loop; other site 272123008788 ATP binding site [chemical binding]; other site 272123008789 Q-loop/lid; other site 272123008790 ABC transporter signature motif; other site 272123008791 Walker B; other site 272123008792 D-loop; other site 272123008793 H-loop/switch region; other site 272123008794 Response regulator receiver domain; Region: Response_reg; pfam00072 272123008795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008796 active site 272123008797 phosphorylation site [posttranslational modification] 272123008798 intermolecular recognition site; other site 272123008799 dimerization interface [polypeptide binding]; other site 272123008800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123008801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123008802 metal binding site [ion binding]; metal-binding site 272123008803 active site 272123008804 I-site; other site 272123008805 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123008806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123008807 catalytic residues [active] 272123008808 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 272123008809 metal ion-dependent adhesion site (MIDAS); other site 272123008810 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 272123008811 metal ion-dependent adhesion site (MIDAS); other site 272123008812 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 272123008813 metal ion-dependent adhesion site (MIDAS); other site 272123008814 Predicted transcriptional regulators [Transcription]; Region: COG1733 272123008815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123008816 dimerization interface [polypeptide binding]; other site 272123008817 putative DNA binding site [nucleotide binding]; other site 272123008818 putative Zn2+ binding site [ion binding]; other site 272123008819 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 272123008820 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 272123008821 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 272123008822 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272123008823 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 272123008824 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 272123008825 putative active site [active] 272123008826 catalytic site [active] 272123008827 NifU-like domain; Region: NifU; pfam01106 272123008828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008829 TPR repeat; Region: TPR_11; pfam13414 272123008830 binding surface 272123008831 TPR motif; other site 272123008832 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272123008833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272123008834 nucleotide binding site [chemical binding]; other site 272123008835 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008836 putative active site [active] 272123008837 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123008838 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272123008839 putative C-terminal domain interface [polypeptide binding]; other site 272123008840 putative GSH binding site (G-site) [chemical binding]; other site 272123008841 putative dimer interface [polypeptide binding]; other site 272123008842 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272123008843 N-terminal domain interface [polypeptide binding]; other site 272123008844 dimer interface [polypeptide binding]; other site 272123008845 substrate binding pocket (H-site) [chemical binding]; other site 272123008846 Chlorite dismutase; Region: Chlor_dismutase; cl01280 272123008847 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008848 putative active site [active] 272123008849 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123008850 putative active site [active] 272123008851 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272123008852 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123008853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123008854 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123008855 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272123008856 GrpE; Region: GrpE; pfam01025 272123008857 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272123008858 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123008859 HSP70 interaction site [polypeptide binding]; other site 272123008860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123008861 binding surface 272123008862 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123008863 TPR motif; other site 272123008864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123008865 TPR motif; other site 272123008866 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123008867 GAF domain; Region: GAF_3; pfam13492 272123008868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008869 dimer interface [polypeptide binding]; other site 272123008870 phosphorylation site [posttranslational modification] 272123008871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008872 ATP binding site [chemical binding]; other site 272123008873 Mg2+ binding site [ion binding]; other site 272123008874 G-X-G motif; other site 272123008875 GTP-binding protein LepA; Provisional; Region: PRK05433 272123008876 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272123008877 G1 box; other site 272123008878 putative GEF interaction site [polypeptide binding]; other site 272123008879 GTP/Mg2+ binding site [chemical binding]; other site 272123008880 Switch I region; other site 272123008881 G2 box; other site 272123008882 G3 box; other site 272123008883 Switch II region; other site 272123008884 G4 box; other site 272123008885 G5 box; other site 272123008886 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272123008887 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272123008888 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272123008889 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008890 putative active site [active] 272123008891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123008892 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123008893 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 272123008894 proposed catalytic triad [active] 272123008895 active site nucleophile [active] 272123008896 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 272123008897 Restriction endonuclease; Region: Mrr_cat; pfam04471 272123008898 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 272123008899 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123008900 cofactor binding site; other site 272123008901 DNA binding site [nucleotide binding] 272123008902 substrate interaction site [chemical binding]; other site 272123008903 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123008904 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272123008905 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272123008906 dimer interface [polypeptide binding]; other site 272123008907 anticodon binding site; other site 272123008908 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272123008909 homodimer interface [polypeptide binding]; other site 272123008910 motif 1; other site 272123008911 active site 272123008912 motif 2; other site 272123008913 GAD domain; Region: GAD; pfam02938 272123008914 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272123008915 active site 272123008916 motif 3; other site 272123008917 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 272123008918 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272123008919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123008920 FeS/SAM binding site; other site 272123008921 TRAM domain; Region: TRAM; pfam01938 272123008922 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272123008923 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 272123008924 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 272123008925 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 272123008926 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 272123008927 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272123008928 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123008929 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272123008930 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272123008931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123008932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123008933 dimer interface [polypeptide binding]; other site 272123008934 phosphorylation site [posttranslational modification] 272123008935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123008936 ATP binding site [chemical binding]; other site 272123008937 Mg2+ binding site [ion binding]; other site 272123008938 G-X-G motif; other site 272123008939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123008940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123008941 active site 272123008942 phosphorylation site [posttranslational modification] 272123008943 intermolecular recognition site; other site 272123008944 dimerization interface [polypeptide binding]; other site 272123008945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123008946 DNA binding residues [nucleotide binding] 272123008947 dimerization interface [polypeptide binding]; other site 272123008948 Ion channel; Region: Ion_trans_2; pfam07885 272123008949 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272123008950 TrkA-N domain; Region: TrkA_N; pfam02254 272123008951 TrkA-C domain; Region: TrkA_C; pfam02080 272123008952 acetylornithine aminotransferase; Provisional; Region: PRK02627 272123008953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272123008954 inhibitor-cofactor binding pocket; inhibition site 272123008955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123008956 catalytic residue [active] 272123008957 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 272123008958 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 272123008959 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 272123008960 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 272123008961 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272123008962 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272123008963 dimer interface [polypeptide binding]; other site 272123008964 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272123008965 catalytic triad [active] 272123008966 peroxidatic and resolving cysteines [active] 272123008967 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 272123008968 putative catalytic residues [active] 272123008969 chaperone protein DnaJ; Provisional; Region: PRK14299 272123008970 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123008971 HSP70 interaction site [polypeptide binding]; other site 272123008972 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272123008973 substrate binding site [polypeptide binding]; other site 272123008974 dimer interface [polypeptide binding]; other site 272123008975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 272123008976 AAA domain; Region: AAA_33; pfam13671 272123008977 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 272123008978 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272123008979 ligand binding site; other site 272123008980 oligomer interface; other site 272123008981 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272123008982 dimer interface [polypeptide binding]; other site 272123008983 N-terminal domain interface [polypeptide binding]; other site 272123008984 sulfate 1 binding site; other site 272123008985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123008986 S-adenosylmethionine binding site [chemical binding]; other site 272123008987 Predicted integral membrane protein [Function unknown]; Region: COG5652 272123008988 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123008989 putative active site [active] 272123008990 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272123008991 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 272123008992 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272123008993 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272123008994 motif 1; other site 272123008995 active site 272123008996 motif 2; other site 272123008997 motif 3; other site 272123008998 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272123008999 DHHA1 domain; Region: DHHA1; pfam02272 272123009000 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 272123009001 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 272123009002 GIY-YIG motif/motif A; other site 272123009003 active site 272123009004 catalytic site [active] 272123009005 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009006 putative active site [active] 272123009007 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272123009008 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; Region: 17beta-HSD1_like_SDR_c; cd05356 272123009009 putative NAD(P) binding site [chemical binding]; other site 272123009010 active site 272123009011 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 272123009012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272123009013 RNA binding surface [nucleotide binding]; other site 272123009014 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 272123009015 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 272123009016 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 272123009017 Walker A motif; other site 272123009018 ATP binding site [chemical binding]; other site 272123009019 Walker B motif; other site 272123009020 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272123009021 ATP binding site [chemical binding]; other site 272123009022 Walker B motif; other site 272123009023 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272123009024 tetramer interface [polypeptide binding]; other site 272123009025 dimer interface [polypeptide binding]; other site 272123009026 KaiA domain; Region: KaiA; pfam07688 272123009027 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123009028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009030 dimer interface [polypeptide binding]; other site 272123009031 phosphorylation site [posttranslational modification] 272123009032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009033 ATP binding site [chemical binding]; other site 272123009034 Mg2+ binding site [ion binding]; other site 272123009035 G-X-G motif; other site 272123009036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123009037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009038 active site 272123009039 phosphorylation site [posttranslational modification] 272123009040 intermolecular recognition site; other site 272123009041 dimerization interface [polypeptide binding]; other site 272123009042 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 272123009043 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123009044 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123009045 Protein of unknown function (DUF565); Region: DUF565; pfam04483 272123009046 Predicted kinase [General function prediction only]; Region: COG4240 272123009047 active site 272123009048 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 272123009049 GAF domain; Region: GAF; pfam01590 272123009050 Phytochrome region; Region: PHY; pfam00360 272123009051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009052 dimer interface [polypeptide binding]; other site 272123009053 phosphorylation site [posttranslational modification] 272123009054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009055 ATP binding site [chemical binding]; other site 272123009056 Mg2+ binding site [ion binding]; other site 272123009057 G-X-G motif; other site 272123009058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123009059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009060 active site 272123009061 phosphorylation site [posttranslational modification] 272123009062 intermolecular recognition site; other site 272123009063 dimerization interface [polypeptide binding]; other site 272123009064 Response regulator receiver domain; Region: Response_reg; pfam00072 272123009065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009066 active site 272123009067 phosphorylation site [posttranslational modification] 272123009068 intermolecular recognition site; other site 272123009069 dimerization interface [polypeptide binding]; other site 272123009070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123009071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123009072 metal binding site [ion binding]; metal-binding site 272123009073 active site 272123009074 I-site; other site 272123009075 Response regulator receiver domain; Region: Response_reg; pfam00072 272123009076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009077 active site 272123009078 phosphorylation site [posttranslational modification] 272123009079 intermolecular recognition site; other site 272123009080 dimerization interface [polypeptide binding]; other site 272123009081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123009082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123009083 metal binding site [ion binding]; metal-binding site 272123009084 active site 272123009085 I-site; other site 272123009086 Uncharacterized conserved protein [Function unknown]; Region: COG0397 272123009087 hypothetical protein; Validated; Region: PRK00029 272123009088 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272123009089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272123009090 biotin synthase; Region: bioB; TIGR00433 272123009091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123009092 FeS/SAM binding site; other site 272123009093 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272123009094 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272123009095 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272123009096 active site 272123009097 dimer interface [polypeptide binding]; other site 272123009098 metal binding site [ion binding]; metal-binding site 272123009099 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272123009100 Cytochrome P450; Region: p450; cl12078 272123009101 Cache domain; Region: Cache_1; pfam02743 272123009102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123009104 dimerization interface [polypeptide binding]; other site 272123009105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009106 dimer interface [polypeptide binding]; other site 272123009107 phosphorylation site [posttranslational modification] 272123009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009109 ATP binding site [chemical binding]; other site 272123009110 Mg2+ binding site [ion binding]; other site 272123009111 G-X-G motif; other site 272123009112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272123009113 active site 272123009114 motif I; other site 272123009115 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272123009116 motif II; other site 272123009117 NurA nuclease; Region: NurA; smart00933 272123009118 GTP-binding protein YchF; Reviewed; Region: PRK09601 272123009119 YchF GTPase; Region: YchF; cd01900 272123009120 G1 box; other site 272123009121 GTP/Mg2+ binding site [chemical binding]; other site 272123009122 Switch I region; other site 272123009123 G2 box; other site 272123009124 Switch II region; other site 272123009125 G3 box; other site 272123009126 G4 box; other site 272123009127 G5 box; other site 272123009128 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272123009129 Protein kinase domain; Region: Pkinase; pfam00069 272123009130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009131 active site 272123009132 ATP binding site [chemical binding]; other site 272123009133 substrate binding site [chemical binding]; other site 272123009134 substrate binding site [chemical binding]; other site 272123009135 activation loop (A-loop); other site 272123009136 activation loop (A-loop); other site 272123009137 AAA ATPase domain; Region: AAA_16; pfam13191 272123009138 Predicted ATPase [General function prediction only]; Region: COG3899 272123009139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009140 GAF domain; Region: GAF; pfam01590 272123009141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009143 ATP binding site [chemical binding]; other site 272123009144 Mg2+ binding site [ion binding]; other site 272123009145 G-X-G motif; other site 272123009146 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 272123009147 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 272123009148 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272123009149 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272123009150 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272123009151 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123009152 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123009153 phosphopeptide binding site; other site 272123009154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009156 active site 272123009157 ATP binding site [chemical binding]; other site 272123009158 substrate binding site [chemical binding]; other site 272123009159 activation loop (A-loop); other site 272123009160 Uncharacterized conserved protein [Function unknown]; Region: COG0432 272123009161 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 272123009162 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272123009163 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272123009164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123009165 catalytic residue [active] 272123009166 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 272123009167 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272123009168 RNase_H superfamily; Region: RNase_H_2; pfam13482 272123009169 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 272123009170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 272123009171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009173 active site 272123009174 ATP binding site [chemical binding]; other site 272123009175 substrate binding site [chemical binding]; other site 272123009176 activation loop (A-loop); other site 272123009177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123009178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009179 active site 272123009180 ATP binding site [chemical binding]; other site 272123009181 substrate binding site [chemical binding]; other site 272123009182 activation loop (A-loop); other site 272123009183 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272123009184 AAA domain; Region: AAA_18; pfam13238 272123009185 active site 272123009186 Uncharacterized conserved protein [Function unknown]; Region: COG3506 272123009187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272123009188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272123009189 MarR family; Region: MarR_2; cl17246 272123009190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272123009191 S-layer homology domain; Region: SLH; pfam00395 272123009192 S-layer homology domain; Region: SLH; pfam00395 272123009193 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123009194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 272123009195 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 272123009196 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272123009197 active site 272123009198 putative substrate binding pocket [chemical binding]; other site 272123009199 Isochorismatase family; Region: Isochorismatase; pfam00857 272123009200 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272123009201 catalytic triad [active] 272123009202 conserved cis-peptide bond; other site 272123009203 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272123009204 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 272123009205 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272123009206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123009207 dimer interface [polypeptide binding]; other site 272123009208 conserved gate region; other site 272123009209 putative PBP binding loops; other site 272123009210 ABC-ATPase subunit interface; other site 272123009211 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272123009212 dinuclear metal binding motif [ion binding]; other site 272123009213 acyl-ACP reductase; Provisional; Region: PRK14982 272123009214 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272123009215 NAD(P) binding pocket [chemical binding]; other site 272123009216 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272123009217 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272123009218 short chain dehydrogenase; Provisional; Region: PRK07454 272123009219 classical (c) SDRs; Region: SDR_c; cd05233 272123009220 NAD(P) binding site [chemical binding]; other site 272123009221 active site 272123009222 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 272123009223 homodecamer interface [polypeptide binding]; other site 272123009224 GTP cyclohydrolase I; Provisional; Region: PLN03044 272123009225 active site 272123009226 putative catalytic site residues [active] 272123009227 zinc binding site [ion binding]; other site 272123009228 GTP-CH-I/GFRP interaction surface; other site 272123009229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123009230 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123009231 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009232 putative active site [active] 272123009233 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272123009234 active site 272123009235 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 272123009236 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 272123009237 Peptidase family M50; Region: Peptidase_M50; pfam02163 272123009238 active site 272123009239 putative substrate binding region [chemical binding]; other site 272123009240 FOG: CBS domain [General function prediction only]; Region: COG0517 272123009241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 272123009242 Caspase domain; Region: Peptidase_C14; pfam00656 272123009243 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272123009244 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123009245 Late competence development protein ComFB; Region: ComFB; pfam10719 272123009246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272123009247 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272123009248 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 272123009249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123009250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123009251 DNA binding residues [nucleotide binding] 272123009252 Putative zinc-finger; Region: zf-HC2; pfam13490 272123009253 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 272123009254 DctM-like transporters; Region: DctM; pfam06808 272123009255 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 272123009256 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 272123009257 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 272123009258 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272123009259 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123009260 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272123009261 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272123009262 HIGH motif; other site 272123009263 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272123009264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272123009265 active site 272123009266 KMSKS motif; other site 272123009267 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272123009268 tRNA binding surface [nucleotide binding]; other site 272123009269 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123009270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123009271 active site 272123009272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123009273 Walker A/P-loop; other site 272123009274 ATP binding site [chemical binding]; other site 272123009275 AAA domain; Region: AAA_21; pfam13304 272123009276 CAAX protease self-immunity; Region: Abi; pfam02517 272123009277 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123009278 Calx-beta domain; Region: Calx-beta; cl02522 272123009279 Calx-beta domain; Region: Calx-beta; cl02522 272123009280 Calx-beta domain; Region: Calx-beta; cl02522 272123009281 Calx-beta domain; Region: Calx-beta; cl02522 272123009282 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123009283 Uncharacterized conserved protein [Function unknown]; Region: COG3937 272123009284 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 272123009285 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272123009286 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272123009287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272123009288 Walker A motif; other site 272123009289 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123009290 protein-splicing catalytic site; other site 272123009291 thioester formation/cholesterol transfer; other site 272123009292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123009293 non-specific DNA binding site [nucleotide binding]; other site 272123009294 salt bridge; other site 272123009295 sequence-specific DNA binding site [nucleotide binding]; other site 272123009296 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123009297 protein-splicing catalytic site; other site 272123009298 replicative DNA helicase; Region: DnaB; TIGR00665 272123009299 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272123009300 ATP binding site [chemical binding]; other site 272123009301 Walker B motif; other site 272123009302 DNA binding loops [nucleotide binding] 272123009303 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272123009304 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272123009305 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272123009306 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 272123009307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123009308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123009309 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123009310 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123009311 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123009312 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272123009313 Walker A/P-loop; other site 272123009314 ATP binding site [chemical binding]; other site 272123009315 Q-loop/lid; other site 272123009316 ABC transporter signature motif; other site 272123009317 Walker B; other site 272123009318 D-loop; other site 272123009319 H-loop/switch region; other site 272123009320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123009321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123009322 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 272123009323 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272123009324 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272123009325 ABC1 family; Region: ABC1; cl17513 272123009326 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 272123009327 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 272123009328 Zn binding site [ion binding]; other site 272123009329 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 272123009330 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123009331 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123009332 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123009333 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123009334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123009335 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123009336 Caspase domain; Region: Peptidase_C14; pfam00656 272123009337 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123009338 Predicted transcriptional regulator [Transcription]; Region: COG3682 272123009339 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272123009340 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 272123009341 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272123009342 Di-iron ligands [ion binding]; other site 272123009343 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272123009344 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 272123009345 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 272123009346 diiron binding motif [ion binding]; other site 272123009347 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123009348 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009349 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009350 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009351 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123009354 dimerization interface [polypeptide binding]; other site 272123009355 putative DNA binding site [nucleotide binding]; other site 272123009356 putative Zn2+ binding site [ion binding]; other site 272123009357 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 272123009358 nitrogenase reductase; Reviewed; Region: PRK13236 272123009359 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 272123009360 Nucleotide-binding sites [chemical binding]; other site 272123009361 Walker A motif; other site 272123009362 Switch I region of nucleotide binding site; other site 272123009363 Fe4S4 binding sites [ion binding]; other site 272123009364 Switch II region of nucleotide binding site; other site 272123009365 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123009366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009367 YacP-like NYN domain; Region: NYN_YacP; cl01491 272123009368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272123009369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272123009370 Walker A/P-loop; other site 272123009371 ATP binding site [chemical binding]; other site 272123009372 Q-loop/lid; other site 272123009373 ABC transporter signature motif; other site 272123009374 Walker B; other site 272123009375 D-loop; other site 272123009376 H-loop/switch region; other site 272123009377 hypothetical protein; Provisional; Region: PRK13683 272123009378 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 272123009379 D1 interface; other site 272123009380 chlorophyll binding site; other site 272123009381 pheophytin binding site; other site 272123009382 beta carotene binding site; other site 272123009383 cytochrome b559 beta interface; other site 272123009384 quinone binding site; other site 272123009385 cytochrome b559 alpha interface; other site 272123009386 protein J interface; other site 272123009387 protein H interface; other site 272123009388 protein X interface; other site 272123009389 core light harvesting protein interface; other site 272123009390 protein L interface; other site 272123009391 CP43 interface; other site 272123009392 protein T interface; other site 272123009393 Fe binding site [ion binding]; other site 272123009394 protein M interface; other site 272123009395 Mn-stabilizing polypeptide interface; other site 272123009396 bromide binding site; other site 272123009397 cytochrome c-550 interface; other site 272123009398 S-layer homology domain; Region: SLH; pfam00395 272123009399 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123009400 Predicted transcriptional regulator [Transcription]; Region: COG1959 272123009401 Transcriptional regulator; Region: Rrf2; pfam02082 272123009402 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123009403 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123009404 dimer interface [polypeptide binding]; other site 272123009405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123009406 catalytic residue [active] 272123009407 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272123009408 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123009409 HSP70 interaction site [polypeptide binding]; other site 272123009410 PIN domain; Region: PIN_3; cl17397 272123009411 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272123009412 active site 272123009413 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272123009414 active site 272123009415 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009416 putative active site [active] 272123009417 Protease prsW family; Region: PrsW-protease; cl15823 272123009418 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123009419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123009420 S-adenosylmethionine binding site [chemical binding]; other site 272123009421 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 272123009422 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 272123009423 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 272123009424 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 272123009425 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 272123009426 protein binding site [polypeptide binding]; other site 272123009427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123009428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123009429 ligand binding site [chemical binding]; other site 272123009430 flexible hinge region; other site 272123009431 RNA polymerase factor sigma-70; Validated; Region: PRK08295 272123009432 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123009433 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 272123009434 Hexamer interface [polypeptide binding]; other site 272123009435 Hexagonal pore residue; other site 272123009436 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272123009437 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 272123009438 Hexamer interface [polypeptide binding]; other site 272123009439 Hexagonal pore residue; other site 272123009440 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123009441 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123009442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123009443 P-loop; other site 272123009444 Magnesium ion binding site [ion binding]; other site 272123009445 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272123009446 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272123009447 trimer interface [polypeptide binding]; other site 272123009448 active site 272123009449 substrate binding site [chemical binding]; other site 272123009450 CoA binding site [chemical binding]; other site 272123009451 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123009452 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 272123009453 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 272123009454 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272123009455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123009456 Walker A/P-loop; other site 272123009457 ATP binding site [chemical binding]; other site 272123009458 Q-loop/lid; other site 272123009459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272123009460 ABC transporter signature motif; other site 272123009461 Walker B; other site 272123009462 D-loop; other site 272123009463 ABC transporter; Region: ABC_tran_2; pfam12848 272123009464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272123009465 Predicted membrane protein [Function unknown]; Region: COG3431 272123009466 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 272123009467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272123009468 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 272123009469 substrate binding pocket [chemical binding]; other site 272123009470 substrate-Mg2+ binding site; other site 272123009471 aspartate-rich region 1; other site 272123009472 aspartate-rich region 2; other site 272123009473 DevC protein; Region: devC; TIGR01185 272123009474 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123009475 FtsX-like permease family; Region: FtsX; pfam02687 272123009476 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123009477 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123009478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123009479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123009480 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 272123009481 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009482 putative active site [active] 272123009483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009484 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009485 active site 272123009486 ATP binding site [chemical binding]; other site 272123009487 substrate binding site [chemical binding]; other site 272123009488 activation loop (A-loop); other site 272123009489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009490 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123009491 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009492 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 272123009493 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272123009494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272123009495 inhibitor-cofactor binding pocket; inhibition site 272123009496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123009497 catalytic residue [active] 272123009498 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272123009499 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272123009500 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272123009501 metal binding site [ion binding]; metal-binding site 272123009502 CheB methylesterase; Region: CheB_methylest; pfam01339 272123009503 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272123009504 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272123009505 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272123009506 PAS domain; Region: PAS_10; pfam13596 272123009507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009509 dimer interface [polypeptide binding]; other site 272123009510 phosphorylation site [posttranslational modification] 272123009511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009512 ATP binding site [chemical binding]; other site 272123009513 Mg2+ binding site [ion binding]; other site 272123009514 G-X-G motif; other site 272123009515 Response regulator receiver domain; Region: Response_reg; pfam00072 272123009516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009517 active site 272123009518 phosphorylation site [posttranslational modification] 272123009519 intermolecular recognition site; other site 272123009520 dimerization interface [polypeptide binding]; other site 272123009521 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 272123009522 aromatic arch; other site 272123009523 DCoH dimer interaction site [polypeptide binding]; other site 272123009524 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272123009525 DCoH tetramer interaction site [polypeptide binding]; other site 272123009526 substrate binding site [chemical binding]; other site 272123009527 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272123009528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123009529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123009530 DNA binding residues [nucleotide binding] 272123009531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009532 binding surface 272123009533 TPR repeat; Region: TPR_11; pfam13414 272123009534 TPR motif; other site 272123009535 TPR repeat; Region: TPR_11; pfam13414 272123009536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009537 TPR motif; other site 272123009538 binding surface 272123009539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009540 TPR motif; other site 272123009541 binding surface 272123009542 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123009543 oligomeric interface; other site 272123009544 putative active site [active] 272123009545 homodimer interface [polypeptide binding]; other site 272123009546 FecR protein; Region: FecR; pfam04773 272123009547 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272123009548 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 272123009549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009550 GAF domain; Region: GAF; pfam01590 272123009551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009553 dimer interface [polypeptide binding]; other site 272123009554 phosphorylation site [posttranslational modification] 272123009555 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 272123009556 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272123009557 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272123009558 inhibitor-cofactor binding pocket; inhibition site 272123009559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123009560 catalytic residue [active] 272123009561 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 272123009562 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 272123009563 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 272123009564 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272123009565 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272123009566 SLBB domain; Region: SLBB; pfam10531 272123009567 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272123009568 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272123009569 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123009570 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123009571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009572 active site 272123009573 phosphorylation site [posttranslational modification] 272123009574 intermolecular recognition site; other site 272123009575 dimerization interface [polypeptide binding]; other site 272123009576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123009577 DNA binding site [nucleotide binding] 272123009578 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 272123009579 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 272123009580 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272123009581 dimer interface [polypeptide binding]; other site 272123009582 tetramer interface [polypeptide binding]; other site 272123009583 PYR/PP interface [polypeptide binding]; other site 272123009584 TPP binding site [chemical binding]; other site 272123009585 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272123009586 TPP-binding site; other site 272123009587 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272123009588 homooctamer interface [polypeptide binding]; other site 272123009589 active site 272123009590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 272123009591 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009592 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009593 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123009594 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123009595 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009596 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272123009597 dimer interface [polypeptide binding]; other site 272123009598 motif 1; other site 272123009599 active site 272123009600 motif 2; other site 272123009601 motif 3; other site 272123009602 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 272123009603 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272123009604 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272123009605 Competence protein; Region: Competence; pfam03772 272123009606 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272123009607 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 272123009608 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 272123009609 putative active site [active] 272123009610 putative metal binding site [ion binding]; other site 272123009611 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009612 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009613 active site 272123009614 ATP binding site [chemical binding]; other site 272123009615 substrate binding site [chemical binding]; other site 272123009616 activation loop (A-loop); other site 272123009617 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272123009618 D-xylulose kinase; Region: XylB; TIGR01312 272123009619 nucleotide binding site [chemical binding]; other site 272123009620 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 272123009621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009622 TPR repeat; Region: TPR_11; pfam13414 272123009623 binding surface 272123009624 TPR motif; other site 272123009625 TPR repeat; Region: TPR_11; pfam13414 272123009626 TPR repeat; Region: TPR_11; pfam13414 272123009627 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123009628 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272123009629 putative C-terminal domain interface [polypeptide binding]; other site 272123009630 putative GSH binding site (G-site) [chemical binding]; other site 272123009631 putative dimer interface [polypeptide binding]; other site 272123009632 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272123009633 N-terminal domain interface [polypeptide binding]; other site 272123009634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 272123009635 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 272123009636 MAPEG family; Region: MAPEG; cl09190 272123009637 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 272123009638 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123009639 DRTGG domain; Region: DRTGG; pfam07085 272123009640 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272123009641 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272123009642 DXD motif; other site 272123009643 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272123009644 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 272123009645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123009646 dimer interface [polypeptide binding]; other site 272123009647 putative metal binding site [ion binding]; other site 272123009648 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123009649 Recombinase; Region: Recombinase; pfam07508 272123009650 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272123009651 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123009652 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272123009653 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272123009654 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272123009655 Cl- selectivity filter; other site 272123009656 Cl- binding residues [ion binding]; other site 272123009657 pore gating glutamate residue; other site 272123009658 dimer interface [polypeptide binding]; other site 272123009659 FOG: CBS domain [General function prediction only]; Region: COG0517 272123009660 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 272123009661 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 272123009662 Predicted transcriptional regulator [Transcription]; Region: COG1959 272123009663 Transcriptional regulator; Region: Rrf2; cl17282 272123009664 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 272123009665 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272123009666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123009667 active site 272123009668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009669 active site 272123009670 phosphorylation site [posttranslational modification] 272123009671 intermolecular recognition site; other site 272123009672 dimerization interface [polypeptide binding]; other site 272123009673 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272123009674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009675 putative active site [active] 272123009676 heme pocket [chemical binding]; other site 272123009677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009678 dimer interface [polypeptide binding]; other site 272123009679 phosphorylation site [posttranslational modification] 272123009680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009681 ATP binding site [chemical binding]; other site 272123009682 Mg2+ binding site [ion binding]; other site 272123009683 G-X-G motif; other site 272123009684 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123009685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009686 active site 272123009687 phosphorylation site [posttranslational modification] 272123009688 intermolecular recognition site; other site 272123009689 dimerization interface [polypeptide binding]; other site 272123009690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009691 Response regulator receiver domain; Region: Response_reg; pfam00072 272123009692 active site 272123009693 phosphorylation site [posttranslational modification] 272123009694 intermolecular recognition site; other site 272123009695 dimerization interface [polypeptide binding]; other site 272123009696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009697 PAS fold; Region: PAS_3; pfam08447 272123009698 putative active site [active] 272123009699 heme pocket [chemical binding]; other site 272123009700 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009701 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123009702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009703 dimer interface [polypeptide binding]; other site 272123009704 phosphorylation site [posttranslational modification] 272123009705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009706 ATP binding site [chemical binding]; other site 272123009707 Mg2+ binding site [ion binding]; other site 272123009708 G-X-G motif; other site 272123009709 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009710 GAF domain; Region: GAF; pfam01590 272123009711 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123009712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009713 putative active site [active] 272123009714 heme pocket [chemical binding]; other site 272123009715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123009716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009717 putative active site [active] 272123009718 heme pocket [chemical binding]; other site 272123009719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009720 dimer interface [polypeptide binding]; other site 272123009721 phosphorylation site [posttranslational modification] 272123009722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009723 ATP binding site [chemical binding]; other site 272123009724 Mg2+ binding site [ion binding]; other site 272123009725 G-X-G motif; other site 272123009726 Response regulator receiver domain; Region: Response_reg; pfam00072 272123009727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009728 active site 272123009729 phosphorylation site [posttranslational modification] 272123009730 intermolecular recognition site; other site 272123009731 dimerization interface [polypeptide binding]; other site 272123009732 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272123009733 MoaE homodimer interface [polypeptide binding]; other site 272123009734 MoaD interaction [polypeptide binding]; other site 272123009735 active site residues [active] 272123009736 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 272123009737 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 272123009738 TPR repeat; Region: TPR_11; pfam13414 272123009739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009740 binding surface 272123009741 TPR motif; other site 272123009742 TPR repeat; Region: TPR_11; pfam13414 272123009743 TPR repeat; Region: TPR_11; pfam13414 272123009744 TPR repeat; Region: TPR_11; pfam13414 272123009745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009746 binding surface 272123009747 TPR motif; other site 272123009748 TPR repeat; Region: TPR_11; pfam13414 272123009749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123009750 TPR motif; other site 272123009751 binding surface 272123009752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123009753 S-adenosylmethionine binding site [chemical binding]; other site 272123009754 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272123009755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123009756 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123009757 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009758 putative active site [active] 272123009759 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123009760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123009761 active site 272123009762 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272123009763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123009764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272123009765 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272123009766 active site 272123009767 ribulose/triose binding site [chemical binding]; other site 272123009768 phosphate binding site [ion binding]; other site 272123009769 substrate (anthranilate) binding pocket [chemical binding]; other site 272123009770 product (indole) binding pocket [chemical binding]; other site 272123009771 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 272123009772 homodimer interface [polypeptide binding]; other site 272123009773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123009774 catalytic residue [active] 272123009775 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 272123009776 Uncharacterized conserved protein [Function unknown]; Region: COG1430 272123009777 acetolactate synthase; Reviewed; Region: PRK08322 272123009778 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272123009779 PYR/PP interface [polypeptide binding]; other site 272123009780 dimer interface [polypeptide binding]; other site 272123009781 TPP binding site [chemical binding]; other site 272123009782 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272123009783 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 272123009784 TPP-binding site [chemical binding]; other site 272123009785 dimer interface [polypeptide binding]; other site 272123009786 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 272123009787 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272123009788 NAD(P) binding site [chemical binding]; other site 272123009789 catalytic residues [active] 272123009790 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123009791 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123009792 phosphopeptide binding site; other site 272123009793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009794 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123009795 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123009796 cyclase homology domain; Region: CHD; cd07302 272123009797 nucleotidyl binding site; other site 272123009798 metal binding site [ion binding]; metal-binding site 272123009799 dimer interface [polypeptide binding]; other site 272123009800 VanZ like family; Region: VanZ; pfam04892 272123009801 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272123009802 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272123009803 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272123009804 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272123009805 GTP/Mg2+ binding site [chemical binding]; other site 272123009806 G4 box; other site 272123009807 G5 box; other site 272123009808 G1 box; other site 272123009809 Switch I region; other site 272123009810 G2 box; other site 272123009811 G3 box; other site 272123009812 Switch II region; other site 272123009813 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272123009814 active site 272123009815 metal binding site [ion binding]; metal-binding site 272123009816 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123009817 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009818 putative active site [active] 272123009819 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 272123009820 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 272123009821 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 272123009822 putative active site; other site 272123009823 catalytic residue [active] 272123009824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123009825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123009826 active site 272123009827 ATP binding site [chemical binding]; other site 272123009828 substrate binding site [chemical binding]; other site 272123009829 activation loop (A-loop); other site 272123009830 hydrolase, alpha/beta fold family protein; Region: PLN02824 272123009831 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123009832 S-layer homology domain; Region: SLH; pfam00395 272123009833 S-layer homology domain; Region: SLH; pfam00395 272123009834 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272123009835 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272123009836 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272123009837 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 272123009838 putative active site [active] 272123009839 Zn binding site [ion binding]; other site 272123009840 AAA domain; Region: AAA_30; pfam13604 272123009841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123009842 Walker A motif; other site 272123009843 ATP binding site [chemical binding]; other site 272123009844 AAA domain; Region: AAA_12; pfam13087 272123009845 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 272123009846 putative active site [active] 272123009847 putative catalytic site [active] 272123009848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272123009849 NlpC/P60 family; Region: NLPC_P60; pfam00877 272123009850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123009851 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123009852 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009853 putative active site [active] 272123009854 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272123009855 Protein export membrane protein; Region: SecD_SecF; cl14618 272123009856 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272123009857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123009858 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123009859 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 272123009860 Peptidase family M50; Region: Peptidase_M50; pfam02163 272123009861 active site 272123009862 putative substrate binding region [chemical binding]; other site 272123009863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 272123009864 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123009865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009866 PAS domain; Region: PAS_9; pfam13426 272123009867 putative active site [active] 272123009868 heme pocket [chemical binding]; other site 272123009869 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272123009870 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123009871 ligand binding site [chemical binding]; other site 272123009872 flexible hinge region; other site 272123009873 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272123009874 non-specific DNA interactions [nucleotide binding]; other site 272123009875 DNA binding site [nucleotide binding] 272123009876 sequence specific DNA binding site [nucleotide binding]; other site 272123009877 putative cAMP binding site [chemical binding]; other site 272123009878 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123009879 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 272123009880 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123009881 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272123009882 active site 272123009883 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123009884 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123009885 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123009886 P-loop; other site 272123009887 Magnesium ion binding site [ion binding]; other site 272123009888 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123009889 Magnesium ion binding site [ion binding]; other site 272123009890 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123009891 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123009892 P-loop; other site 272123009893 Magnesium ion binding site [ion binding]; other site 272123009894 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123009895 Magnesium ion binding site [ion binding]; other site 272123009896 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123009897 putative active site [active] 272123009898 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272123009899 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272123009900 HIGH motif; other site 272123009901 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272123009902 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272123009903 active site 272123009904 KMSKS motif; other site 272123009905 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272123009906 tRNA binding surface [nucleotide binding]; other site 272123009907 anticodon binding site; other site 272123009908 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272123009909 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272123009910 Restriction endonuclease; Region: Mrr_cat; pfam04471 272123009911 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123009912 putative binding surface; other site 272123009913 active site 272123009914 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 272123009915 ADP-ribose binding site [chemical binding]; other site 272123009916 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 272123009917 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 272123009918 active site 272123009919 PHP Thumb interface [polypeptide binding]; other site 272123009920 metal binding site [ion binding]; metal-binding site 272123009921 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123009922 protein-splicing catalytic site; other site 272123009923 thioester formation/cholesterol transfer; other site 272123009924 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123009925 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123009926 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123009927 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123009928 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272123009929 Rhodanese Homology Domain; Region: RHOD; smart00450 272123009930 active site residue [active] 272123009931 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272123009932 active site residue [active] 272123009933 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272123009934 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272123009935 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272123009936 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272123009937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123009938 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272123009939 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123009940 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123009941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123009942 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 272123009943 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272123009944 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272123009945 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272123009946 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 272123009947 active site 272123009948 metal binding site [ion binding]; metal-binding site 272123009949 dimerization interface [polypeptide binding]; other site 272123009950 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272123009951 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123009952 anti sigma factor interaction site; other site 272123009953 regulatory phosphorylation site [posttranslational modification]; other site 272123009954 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272123009955 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272123009956 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272123009957 catalytic site [active] 272123009958 subunit interface [polypeptide binding]; other site 272123009959 Predicted membrane protein [Function unknown]; Region: COG2324 272123009960 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272123009961 active site 272123009962 PAS domain S-box; Region: sensory_box; TIGR00229 272123009963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123009964 putative active site [active] 272123009965 heme pocket [chemical binding]; other site 272123009966 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123009967 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123009968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123009969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123009970 dimer interface [polypeptide binding]; other site 272123009971 phosphorylation site [posttranslational modification] 272123009972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123009973 ATP binding site [chemical binding]; other site 272123009974 Mg2+ binding site [ion binding]; other site 272123009975 G-X-G motif; other site 272123009976 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123009977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123009978 active site 272123009979 phosphorylation site [posttranslational modification] 272123009980 intermolecular recognition site; other site 272123009981 dimerization interface [polypeptide binding]; other site 272123009982 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272123009983 RNA/DNA hybrid binding site [nucleotide binding]; other site 272123009984 active site 272123009985 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272123009986 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272123009987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123009988 active site 272123009989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272123009990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123009991 Coenzyme A binding pocket [chemical binding]; other site 272123009992 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272123009993 Walker A/P-loop; other site 272123009994 ATP binding site [chemical binding]; other site 272123009995 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272123009996 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272123009997 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272123009998 ABC transporter signature motif; other site 272123009999 Walker B; other site 272123010000 D-loop; other site 272123010001 H-loop/switch region; other site 272123010002 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123010003 putative active site [active] 272123010004 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 272123010005 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123010006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123010007 MarR family; Region: MarR_2; cl17246 272123010008 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 272123010009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123010010 S-adenosylmethionine binding site [chemical binding]; other site 272123010011 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 272123010012 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272123010013 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272123010014 Walker A/P-loop; other site 272123010015 ATP binding site [chemical binding]; other site 272123010016 Q-loop/lid; other site 272123010017 ABC transporter signature motif; other site 272123010018 Walker B; other site 272123010019 D-loop; other site 272123010020 H-loop/switch region; other site 272123010021 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272123010022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123010024 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123010025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010027 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123010028 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123010029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123010030 active site 272123010031 hypothetical protein; Provisional; Region: PRK07208 272123010032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123010033 UDP-galactopyranose mutase; Region: GLF; pfam03275 272123010034 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123010035 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272123010036 DXD motif; other site 272123010037 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 272123010038 PRC-barrel domain; Region: PRC; pfam05239 272123010039 PRC-barrel domain; Region: PRC; pfam05239 272123010040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010041 TPR repeat; Region: TPR_11; pfam13414 272123010042 binding surface 272123010043 TPR motif; other site 272123010044 TPR repeat; Region: TPR_11; pfam13414 272123010045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010046 binding surface 272123010047 TPR motif; other site 272123010048 TPR repeat; Region: TPR_11; pfam13414 272123010049 TPR repeat; Region: TPR_11; pfam13414 272123010050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010051 binding surface 272123010052 TPR motif; other site 272123010053 TPR repeat; Region: TPR_11; pfam13414 272123010054 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272123010055 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 272123010056 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272123010057 tetramer interface [polypeptide binding]; other site 272123010058 dimer interface [polypeptide binding]; other site 272123010059 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 272123010060 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 272123010061 Walker A motif; other site 272123010062 ATP binding site [chemical binding]; other site 272123010063 Walker B motif; other site 272123010064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 272123010065 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272123010066 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 272123010067 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272123010068 active site 272123010069 homodimer interface [polypeptide binding]; other site 272123010070 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123010071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272123010072 Peptidase family M23; Region: Peptidase_M23; pfam01551 272123010073 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123010074 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123010075 active site 272123010076 metal binding site [ion binding]; metal-binding site 272123010077 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 272123010078 DNA primase; Validated; Region: dnaG; PRK05667 272123010079 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272123010080 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272123010081 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272123010082 active site 272123010083 metal binding site [ion binding]; metal-binding site 272123010084 interdomain interaction site; other site 272123010085 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123010086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010087 active site 272123010088 phosphorylation site [posttranslational modification] 272123010089 intermolecular recognition site; other site 272123010090 dimerization interface [polypeptide binding]; other site 272123010091 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123010092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123010093 metal binding site [ion binding]; metal-binding site 272123010094 active site 272123010095 I-site; other site 272123010096 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123010097 Response regulator receiver domain; Region: Response_reg; pfam00072 272123010098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010099 active site 272123010100 phosphorylation site [posttranslational modification] 272123010101 intermolecular recognition site; other site 272123010102 dimerization interface [polypeptide binding]; other site 272123010103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123010104 PAS fold; Region: PAS_3; pfam08447 272123010105 putative active site [active] 272123010106 heme pocket [chemical binding]; other site 272123010107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123010108 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123010109 putative active site [active] 272123010110 heme pocket [chemical binding]; other site 272123010111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123010112 putative active site [active] 272123010113 heme pocket [chemical binding]; other site 272123010114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123010115 dimer interface [polypeptide binding]; other site 272123010116 phosphorylation site [posttranslational modification] 272123010117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123010118 ATP binding site [chemical binding]; other site 272123010119 Mg2+ binding site [ion binding]; other site 272123010120 G-X-G motif; other site 272123010121 gamma-glutamyl kinase; Provisional; Region: PRK05429 272123010122 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272123010123 nucleotide binding site [chemical binding]; other site 272123010124 homotetrameric interface [polypeptide binding]; other site 272123010125 putative phosphate binding site [ion binding]; other site 272123010126 putative allosteric binding site; other site 272123010127 PUA domain; Region: PUA; pfam01472 272123010128 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 272123010129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123010130 active site 272123010131 motif I; other site 272123010132 motif II; other site 272123010133 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 272123010134 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272123010135 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123010136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123010137 Coenzyme A binding pocket [chemical binding]; other site 272123010138 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272123010139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123010140 substrate binding pocket [chemical binding]; other site 272123010141 membrane-bound complex binding site; other site 272123010142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123010143 dimerization interface [polypeptide binding]; other site 272123010144 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 272123010145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123010146 dimer interface [polypeptide binding]; other site 272123010147 phosphorylation site [posttranslational modification] 272123010148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123010149 ATP binding site [chemical binding]; other site 272123010150 Mg2+ binding site [ion binding]; other site 272123010151 G-X-G motif; other site 272123010152 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 272123010153 UbiA prenyltransferase family; Region: UbiA; pfam01040 272123010154 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272123010155 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272123010156 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272123010157 Zn2+ binding site [ion binding]; other site 272123010158 Mg2+ binding site [ion binding]; other site 272123010159 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 272123010160 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123010161 substrate binding site [chemical binding]; other site 272123010162 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123010163 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123010164 structural tetrad; other site 272123010165 Protein phosphatase 2C; Region: PP2C_2; pfam13672 272123010166 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123010167 metal ion-dependent adhesion site (MIDAS); other site 272123010168 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272123010169 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272123010170 glutamine binding [chemical binding]; other site 272123010171 catalytic triad [active] 272123010172 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272123010173 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272123010174 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272123010175 Condensation domain; Region: Condensation; pfam00668 272123010176 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123010177 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123010178 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123010179 acyl-activating enzyme (AAE) consensus motif; other site 272123010180 AMP binding site [chemical binding]; other site 272123010181 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123010182 Condensation domain; Region: Condensation; pfam00668 272123010183 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123010184 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 272123010185 Condensation domain; Region: Condensation; pfam00668 272123010186 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123010187 Condensation domain; Region: Condensation; pfam00668 272123010188 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123010189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123010190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123010191 acyl-activating enzyme (AAE) consensus motif; other site 272123010192 AMP binding site [chemical binding]; other site 272123010193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123010194 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272123010195 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 272123010196 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 272123010197 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272123010198 active site 272123010199 metal binding site [ion binding]; metal-binding site 272123010200 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272123010201 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 272123010202 homodimer interface [polypeptide binding]; other site 272123010203 substrate-cofactor binding pocket; other site 272123010204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123010205 catalytic residue [active] 272123010206 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123010207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123010208 Coenzyme A binding pocket [chemical binding]; other site 272123010209 Chorismate mutase type II; Region: CM_2; smart00830 272123010210 Cupin domain; Region: Cupin_2; pfam07883 272123010211 Cupin domain; Region: Cupin_2; pfam07883 272123010212 Prephenate dehydratase; Region: PDT; pfam00800 272123010213 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 272123010214 TAP-like protein; Region: Abhydrolase_4; pfam08386 272123010215 SnoaL-like domain; Region: SnoaL_2; pfam12680 272123010216 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272123010217 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272123010218 active site 272123010219 homodimer interface [polypeptide binding]; other site 272123010220 EVE domain; Region: EVE; cl00728 272123010221 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 272123010222 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 272123010223 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123010224 catalytic residues [active] 272123010225 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272123010226 4Fe-4S binding domain; Region: Fer4; pfam00037 272123010227 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272123010228 Uncharacterized conserved protein [Function unknown]; Region: COG5607 272123010229 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272123010230 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272123010231 active site 272123010232 metal binding site [ion binding]; metal-binding site 272123010233 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272123010234 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123010235 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123010236 magnesium chelatase subunit H; Provisional; Region: PLN03241 272123010237 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123010238 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272123010239 TPR repeat; Region: TPR_11; pfam13414 272123010240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010241 binding surface 272123010242 TPR motif; other site 272123010243 TPR repeat; Region: TPR_11; pfam13414 272123010244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010245 binding surface 272123010246 TPR motif; other site 272123010247 TPR repeat; Region: TPR_11; pfam13414 272123010248 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272123010249 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 272123010250 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 272123010251 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 272123010252 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272123010253 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 272123010254 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272123010255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272123010256 ABC-ATPase subunit interface; other site 272123010257 dimer interface [polypeptide binding]; other site 272123010258 putative PBP binding regions; other site 272123010259 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272123010260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272123010261 ABC-ATPase subunit interface; other site 272123010262 dimer interface [polypeptide binding]; other site 272123010263 putative PBP binding regions; other site 272123010264 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272123010265 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272123010266 Walker A/P-loop; other site 272123010267 ATP binding site [chemical binding]; other site 272123010268 Q-loop/lid; other site 272123010269 ABC transporter signature motif; other site 272123010270 Walker B; other site 272123010271 D-loop; other site 272123010272 H-loop/switch region; other site 272123010273 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272123010274 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272123010275 PemK-like protein; Region: PemK; pfam02452 272123010276 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 272123010277 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272123010278 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272123010279 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272123010280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123010281 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 272123010282 Probable transposase; Region: OrfB_IS605; pfam01385 272123010283 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272123010284 Uncharacterized conserved protein [Function unknown]; Region: COG3339 272123010285 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 272123010286 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 272123010287 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272123010288 Predicted membrane protein [Function unknown]; Region: COG1950 272123010289 Thf1-like protein; Reviewed; Region: PRK13266 272123010290 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 272123010291 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 272123010292 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123010293 anti sigma factor interaction site; other site 272123010294 regulatory phosphorylation site [posttranslational modification]; other site 272123010295 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272123010296 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 272123010297 Domain of unknown function DUF59; Region: DUF59; pfam01883 272123010298 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272123010299 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272123010300 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272123010301 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 272123010302 HAS barrel domain; Region: HAS-barrel; pfam09378 272123010303 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272123010304 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272123010305 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 272123010306 Ligand Binding Site [chemical binding]; other site 272123010307 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123010308 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 272123010309 NAD binding site [chemical binding]; other site 272123010310 putative substrate binding site 2 [chemical binding]; other site 272123010311 putative substrate binding site 1 [chemical binding]; other site 272123010312 active site 272123010313 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272123010314 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272123010315 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272123010316 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 272123010317 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 272123010318 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272123010319 Chain length determinant protein; Region: Wzz; pfam02706 272123010320 Chain length determinant protein; Region: Wzz; cl15801 272123010321 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272123010322 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123010323 Magnesium ion binding site [ion binding]; other site 272123010324 putative acyl transferase; Provisional; Region: PRK10502 272123010325 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 272123010326 putative trimer interface [polypeptide binding]; other site 272123010327 putative active site [active] 272123010328 putative substrate binding site [chemical binding]; other site 272123010329 putative CoA binding site [chemical binding]; other site 272123010330 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272123010331 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272123010332 putative active site [active] 272123010333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010334 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 272123010335 putative ADP-binding pocket [chemical binding]; other site 272123010336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010337 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123010338 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123010339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010340 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123010341 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123010342 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123010343 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123010344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123010345 active site 272123010346 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272123010347 trimer interface [polypeptide binding]; other site 272123010348 active site 272123010349 substrate binding site [chemical binding]; other site 272123010350 CoA binding site [chemical binding]; other site 272123010351 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123010352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123010353 active site 272123010354 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123010355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123010356 active site 272123010357 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272123010358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123010359 active site 272123010360 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 272123010361 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123010362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010363 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272123010364 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 272123010365 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123010366 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 272123010367 metal-binding site 272123010368 sulfotransferase; Region: PLN02164 272123010369 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 272123010370 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272123010371 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272123010372 Walker A/P-loop; other site 272123010373 ATP binding site [chemical binding]; other site 272123010374 Q-loop/lid; other site 272123010375 ABC transporter signature motif; other site 272123010376 Walker B; other site 272123010377 D-loop; other site 272123010378 H-loop/switch region; other site 272123010379 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272123010380 putative carbohydrate binding site [chemical binding]; other site 272123010381 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272123010382 ligand-binding site [chemical binding]; other site 272123010383 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272123010384 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123010385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010386 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 272123010387 competence damage-inducible protein A; Provisional; Region: PRK00549 272123010388 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272123010389 putative MPT binding site; other site 272123010390 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272123010391 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272123010392 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272123010393 Mg++ binding site [ion binding]; other site 272123010394 putative catalytic motif [active] 272123010395 substrate binding site [chemical binding]; other site 272123010396 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272123010397 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272123010398 dimer interface [polypeptide binding]; other site 272123010399 active site 272123010400 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272123010401 folate binding site [chemical binding]; other site 272123010402 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 272123010403 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272123010404 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272123010405 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 272123010406 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272123010407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123010408 anti sigma factor interaction site; other site 272123010409 regulatory phosphorylation site [posttranslational modification]; other site 272123010410 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272123010411 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272123010412 argininosuccinate synthase; Provisional; Region: PRK13820 272123010413 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272123010414 ANP binding site [chemical binding]; other site 272123010415 Substrate Binding Site II [chemical binding]; other site 272123010416 Substrate Binding Site I [chemical binding]; other site 272123010417 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 272123010418 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 272123010419 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123010420 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272123010421 Probable Catalytic site; other site 272123010422 metal-binding site 272123010423 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010424 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272123010425 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272123010426 rRNA interaction site [nucleotide binding]; other site 272123010427 S8 interaction site; other site 272123010428 putative laminin-1 binding site; other site 272123010429 elongation factor Ts; Provisional; Region: tsf; PRK09377 272123010430 UBA/TS-N domain; Region: UBA; pfam00627 272123010431 Elongation factor TS; Region: EF_TS; pfam00889 272123010432 Elongation factor TS; Region: EF_TS; pfam00889 272123010433 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272123010434 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272123010435 generic binding surface II; other site 272123010436 ssDNA binding site; other site 272123010437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123010438 ATP binding site [chemical binding]; other site 272123010439 putative Mg++ binding site [ion binding]; other site 272123010440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123010441 nucleotide binding region [chemical binding]; other site 272123010442 ATP-binding site [chemical binding]; other site 272123010443 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123010444 putative active site [active] 272123010445 Predicted ATPase [General function prediction only]; Region: COG4637 272123010446 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 272123010447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123010448 Q-loop/lid; other site 272123010449 ABC transporter signature motif; other site 272123010450 Walker B; other site 272123010451 D-loop; other site 272123010452 H-loop/switch region; other site 272123010453 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 272123010454 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272123010455 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272123010456 Putative Catalytic site; other site 272123010457 DXD motif; other site 272123010458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123010459 putative substrate translocation pore; other site 272123010460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272123010461 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272123010462 trimer interface [polypeptide binding]; other site 272123010463 dimer interface [polypeptide binding]; other site 272123010464 putative active site [active] 272123010465 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 272123010466 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272123010467 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123010468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010469 active site 272123010470 phosphorylation site [posttranslational modification] 272123010471 intermolecular recognition site; other site 272123010472 dimerization interface [polypeptide binding]; other site 272123010473 2TM domain; Region: 2TM; pfam13239 272123010474 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 272123010475 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 272123010476 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 272123010477 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272123010478 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272123010479 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123010480 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272123010481 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272123010482 Fasciclin domain; Region: Fasciclin; pfam02469 272123010483 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 272123010484 heme binding pocket [chemical binding]; other site 272123010485 heme ligand [chemical binding]; other site 272123010486 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 272123010487 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272123010488 active site 272123010489 substrate binding site [chemical binding]; other site 272123010490 metal binding site [ion binding]; metal-binding site 272123010491 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 272123010492 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123010494 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123010495 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123010496 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272123010497 Probable Catalytic site; other site 272123010498 metal-binding site 272123010499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010500 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 272123010501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010502 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 272123010503 putative ADP-binding pocket [chemical binding]; other site 272123010504 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272123010505 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 272123010506 dimer interface [polypeptide binding]; other site 272123010507 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272123010508 catalytic triad [active] 272123010509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123010510 putative active site [active] 272123010511 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123010512 putative active site [active] 272123010513 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 272123010514 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 272123010515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123010516 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123010517 binding surface 272123010518 TPR motif; other site 272123010519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123010520 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272123010521 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 272123010522 Dynamin family; Region: Dynamin_N; pfam00350 272123010523 G1 box; other site 272123010524 GTP/Mg2+ binding site [chemical binding]; other site 272123010525 G2 box; other site 272123010526 Switch I region; other site 272123010527 G3 box; other site 272123010528 Switch II region; other site 272123010529 G4 box; other site 272123010530 G5 box; other site 272123010531 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123010532 HSP70 interaction site [polypeptide binding]; other site 272123010533 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123010534 Dynamin family; Region: Dynamin_N; pfam00350 272123010535 G1 box; other site 272123010536 GTP/Mg2+ binding site [chemical binding]; other site 272123010537 G2 box; other site 272123010538 Switch I region; other site 272123010539 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 272123010540 G3 box; other site 272123010541 Switch II region; other site 272123010542 GTP/Mg2+ binding site [chemical binding]; other site 272123010543 G4 box; other site 272123010544 G5 box; other site 272123010545 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123010546 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123010547 dimer interface [polypeptide binding]; other site 272123010548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123010549 catalytic residue [active] 272123010550 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272123010551 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272123010552 dimer interface [polypeptide binding]; other site 272123010553 [2Fe-2S] cluster binding site [ion binding]; other site 272123010554 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272123010555 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272123010556 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272123010557 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272123010558 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 272123010559 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272123010560 putative ligand binding site [chemical binding]; other site 272123010561 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272123010562 active site lid residues [active] 272123010563 substrate binding pocket [chemical binding]; other site 272123010564 catalytic residues [active] 272123010565 substrate-Mg2+ binding site; other site 272123010566 aspartate-rich region 1; other site 272123010567 aspartate-rich region 2; other site 272123010568 phytoene desaturase; Region: phytoene_desat; TIGR02731 272123010569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123010570 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 272123010571 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272123010572 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272123010573 putative methyltransferase; Provisional; Region: PRK11524 272123010574 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272123010575 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272123010576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123010577 ATP binding site [chemical binding]; other site 272123010578 Mg2+ binding site [ion binding]; other site 272123010579 G-X-G motif; other site 272123010580 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272123010581 ATP binding site [chemical binding]; other site 272123010582 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272123010583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272123010584 active site residue [active] 272123010585 Response regulator receiver domain; Region: Response_reg; pfam00072 272123010586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010587 active site 272123010588 phosphorylation site [posttranslational modification] 272123010589 intermolecular recognition site; other site 272123010590 dimerization interface [polypeptide binding]; other site 272123010591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123010592 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123010593 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 272123010594 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 272123010595 active site 272123010596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010597 active site 272123010598 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 272123010599 phosphorylation site [posttranslational modification] 272123010600 intermolecular recognition site; other site 272123010601 dimerization interface [polypeptide binding]; other site 272123010602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272123010603 putative active site [active] 272123010604 heme pocket [chemical binding]; other site 272123010605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123010606 metal binding site [ion binding]; metal-binding site 272123010607 active site 272123010608 I-site; other site 272123010609 MASE1; Region: MASE1; pfam05231 272123010610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123010611 dimer interface [polypeptide binding]; other site 272123010612 phosphorylation site [posttranslational modification] 272123010613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123010614 ATP binding site [chemical binding]; other site 272123010615 Mg2+ binding site [ion binding]; other site 272123010616 G-X-G motif; other site 272123010617 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123010618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123010619 active site 272123010620 phosphorylation site [posttranslational modification] 272123010621 intermolecular recognition site; other site 272123010622 dimerization interface [polypeptide binding]; other site 272123010623 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272123010624 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272123010625 GDP-binding site [chemical binding]; other site 272123010626 ACT binding site; other site 272123010627 IMP binding site; other site 272123010628 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272123010629 5S rRNA interface [nucleotide binding]; other site 272123010630 CTC domain interface [polypeptide binding]; other site 272123010631 L16 interface [polypeptide binding]; other site 272123010632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 272123010633 Predicted kinase [General function prediction only]; Region: COG0645 272123010634 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272123010635 ATP-binding site [chemical binding]; other site 272123010636 Gluconate-6-phosphate binding site [chemical binding]; other site 272123010637 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272123010638 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272123010639 putative active site [active] 272123010640 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 272123010641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272123010642 active site 272123010643 Protein phosphatase 2C; Region: PP2C; pfam00481 272123010644 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 272123010645 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123010646 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272123010647 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272123010648 metal binding site 2 [ion binding]; metal-binding site 272123010649 putative DNA binding helix; other site 272123010650 metal binding site 1 [ion binding]; metal-binding site 272123010651 dimer interface [polypeptide binding]; other site 272123010652 structural Zn2+ binding site [ion binding]; other site 272123010653 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 272123010654 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272123010655 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272123010656 putative active site [active] 272123010657 catalytic triad [active] 272123010658 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272123010659 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272123010660 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 272123010661 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123010662 GUN4-like; Region: GUN4; pfam05419 272123010663 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272123010664 intersubunit interface [polypeptide binding]; other site 272123010665 active site 272123010666 catalytic residue [active] 272123010667 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272123010668 Recombination protein O N terminal; Region: RecO_N; pfam11967 272123010669 Recombination protein O C terminal; Region: RecO_C; pfam02565 272123010670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123010671 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123010672 putative substrate translocation pore; other site 272123010673 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010674 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123010675 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 272123010676 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 272123010677 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272123010678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123010679 Walker A/P-loop; other site 272123010680 ATP binding site [chemical binding]; other site 272123010681 Q-loop/lid; other site 272123010682 ABC transporter signature motif; other site 272123010683 Walker B; other site 272123010684 D-loop; other site 272123010685 H-loop/switch region; other site 272123010686 ABC transporter; Region: ABC_tran_2; pfam12848 272123010687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272123010688 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272123010689 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272123010690 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 272123010691 Ligand Binding Site [chemical binding]; other site 272123010692 AMIN domain; Region: AMIN; pfam11741 272123010693 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 272123010694 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 272123010695 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272123010696 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272123010697 ribosomal protein L23; Region: rpl23; CHL00030 272123010698 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272123010699 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272123010700 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272123010701 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272123010702 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272123010703 putative translocon binding site; other site 272123010704 protein-rRNA interface [nucleotide binding]; other site 272123010705 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272123010706 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272123010707 G-X-X-G motif; other site 272123010708 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272123010709 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272123010710 23S rRNA interface [nucleotide binding]; other site 272123010711 5S rRNA interface [nucleotide binding]; other site 272123010712 putative antibiotic binding site [chemical binding]; other site 272123010713 L25 interface [polypeptide binding]; other site 272123010714 L27 interface [polypeptide binding]; other site 272123010715 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272123010716 23S rRNA interface [nucleotide binding]; other site 272123010717 putative translocon interaction site; other site 272123010718 signal recognition particle (SRP54) interaction site; other site 272123010719 L23 interface [polypeptide binding]; other site 272123010720 trigger factor interaction site; other site 272123010721 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272123010722 ribosomal protein L14; Region: rpl14; CHL00057 272123010723 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272123010724 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272123010725 RNA binding site [nucleotide binding]; other site 272123010726 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272123010727 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272123010728 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272123010729 ribosomal protein S8; Region: rps8; CHL00042 272123010730 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272123010731 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272123010732 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272123010733 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272123010734 5S rRNA interface [nucleotide binding]; other site 272123010735 L27 interface [polypeptide binding]; other site 272123010736 23S rRNA interface [nucleotide binding]; other site 272123010737 L5 interface [polypeptide binding]; other site 272123010738 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272123010739 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272123010740 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272123010741 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272123010742 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272123010743 SecY translocase; Region: SecY; pfam00344 272123010744 adenylate kinase; Provisional; Region: adk; PRK02496 272123010745 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272123010746 AMP-binding site [chemical binding]; other site 272123010747 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272123010748 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272123010749 rRNA binding site [nucleotide binding]; other site 272123010750 predicted 30S ribosome binding site; other site 272123010751 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272123010752 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272123010753 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272123010754 30S ribosomal protein S11; Validated; Region: PRK05309 272123010755 RNA polymerase alpha subunit; Region: rpoA; CHL00013 272123010756 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272123010757 alphaNTD - beta interaction site [polypeptide binding]; other site 272123010758 alphaNTD homodimer interface [polypeptide binding]; other site 272123010759 alphaNTD - beta' interaction site [polypeptide binding]; other site 272123010760 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272123010761 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272123010762 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272123010763 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272123010764 dimerization interface 3.5A [polypeptide binding]; other site 272123010765 active site 272123010766 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272123010767 23S rRNA interface [nucleotide binding]; other site 272123010768 L3 interface [polypeptide binding]; other site 272123010769 ribosomal protein S9; Region: rps9; CHL00079 272123010770 ribosomal protein L31; Validated; Region: rpl31; CHL00136 272123010771 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272123010772 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272123010773 RF-1 domain; Region: RF-1; pfam00472 272123010774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123010775 non-specific DNA binding site [nucleotide binding]; other site 272123010776 salt bridge; other site 272123010777 sequence-specific DNA binding site [nucleotide binding]; other site 272123010778 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010779 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 272123010780 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123010781 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 272123010782 active site 272123010783 catalytic triad [active] 272123010784 oxyanion hole [active] 272123010785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 272123010786 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123010787 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123010788 phosphopeptide binding site; other site 272123010789 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123010790 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123010791 phosphopeptide binding site; other site 272123010792 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 272123010793 Active_site [active] 272123010794 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272123010795 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 272123010796 ribonuclease III; Reviewed; Region: rnc; PRK00102 272123010797 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272123010798 dimerization interface [polypeptide binding]; other site 272123010799 active site 272123010800 metal binding site [ion binding]; metal-binding site 272123010801 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272123010802 dsRNA binding site [nucleotide binding]; other site 272123010803 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272123010804 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123010805 cofactor binding site; other site 272123010806 DNA binding site [nucleotide binding] 272123010807 substrate interaction site [chemical binding]; other site 272123010808 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123010809 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272123010810 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272123010811 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272123010812 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272123010813 active site 272123010814 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272123010815 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272123010816 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272123010817 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123010818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272123010819 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123010820 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272123010821 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272123010822 ATP binding site [chemical binding]; other site 272123010823 active site 272123010824 substrate binding site [chemical binding]; other site 272123010825 GAF domain; Region: GAF_2; pfam13185 272123010826 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123010827 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123010828 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123010829 PAS fold; Region: PAS_4; pfam08448 272123010830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123010831 putative active site [active] 272123010832 heme pocket [chemical binding]; other site 272123010833 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123010834 cyclase homology domain; Region: CHD; cd07302 272123010835 nucleotidyl binding site; other site 272123010836 metal binding site [ion binding]; metal-binding site 272123010837 dimer interface [polypeptide binding]; other site 272123010838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123010839 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 272123010840 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 272123010841 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123010842 NAD binding site [chemical binding]; other site 272123010843 substrate binding site [chemical binding]; other site 272123010844 active site 272123010845 Ycf46; Provisional; Region: ycf46; CHL00195 272123010846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123010847 Walker A motif; other site 272123010848 ATP binding site [chemical binding]; other site 272123010849 Walker B motif; other site 272123010850 arginine finger; other site 272123010851 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 272123010852 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 272123010853 putative active site [active] 272123010854 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123010855 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123010856 active site 272123010857 AAA domain; Region: AAA_30; pfam13604 272123010858 anthranilate synthase component I; Provisional; Region: PRK13565 272123010859 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272123010860 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272123010861 PsaD; Region: PsaD; pfam02531 272123010862 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 272123010863 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123010864 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123010865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123010866 dimer interface [polypeptide binding]; other site 272123010867 phosphorylation site [posttranslational modification] 272123010868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123010869 ATP binding site [chemical binding]; other site 272123010870 Mg2+ binding site [ion binding]; other site 272123010871 G-X-G motif; other site 272123010872 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 272123010873 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 272123010874 PIN domain; Region: PIN; pfam01850 272123010875 putative active site [active] 272123010876 PemK-like protein; Region: PemK; pfam02452 272123010877 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 272123010878 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 272123010879 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 272123010880 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272123010881 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272123010882 active site 272123010883 dimer interface [polypeptide binding]; other site 272123010884 motif 1; other site 272123010885 motif 2; other site 272123010886 motif 3; other site 272123010887 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272123010888 anticodon binding site; other site 272123010889 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010890 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123010891 active site 272123010892 catalytic residues [active] 272123010893 DNA binding site [nucleotide binding] 272123010894 Int/Topo IB signature motif; other site 272123010895 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272123010896 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272123010897 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 272123010898 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123010899 AIPR protein; Region: AIPR; pfam10592 272123010900 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010901 homoserine kinase; Provisional; Region: PRK01212 272123010902 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272123010903 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272123010904 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 272123010905 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123010906 2TM domain; Region: 2TM; pfam13239 272123010907 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272123010908 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272123010909 cofactor binding site; other site 272123010910 DNA binding site [nucleotide binding] 272123010911 substrate interaction site [chemical binding]; other site 272123010912 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 272123010913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 272123010914 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 272123010915 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123010916 G1 box; other site 272123010917 GTP/Mg2+ binding site [chemical binding]; other site 272123010918 G2 box; other site 272123010919 Switch II region; other site 272123010920 G4 box; other site 272123010921 G5 box; other site 272123010922 Domain of unknown function (DUF697); Region: DUF697; pfam05128 272123010923 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010924 L-asparaginase II; Region: Asparaginase_II; cl01842 272123010925 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 272123010926 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272123010927 putative glycosyl transferase; Provisional; Region: PRK10307 272123010928 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 272123010929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272123010930 anti sigma factor interaction site; other site 272123010931 regulatory phosphorylation site [posttranslational modification]; other site 272123010932 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272123010933 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272123010934 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 272123010935 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 272123010936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123010937 FeS/SAM binding site; other site 272123010938 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 272123010939 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272123010940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123010941 substrate binding pocket [chemical binding]; other site 272123010942 membrane-bound complex binding site; other site 272123010943 hinge residues; other site 272123010944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123010945 dimer interface [polypeptide binding]; other site 272123010946 conserved gate region; other site 272123010947 putative PBP binding loops; other site 272123010948 ABC-ATPase subunit interface; other site 272123010949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123010950 dimer interface [polypeptide binding]; other site 272123010951 conserved gate region; other site 272123010952 putative PBP binding loops; other site 272123010953 ABC-ATPase subunit interface; other site 272123010954 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272123010955 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272123010956 Walker A/P-loop; other site 272123010957 ATP binding site [chemical binding]; other site 272123010958 Q-loop/lid; other site 272123010959 ABC transporter signature motif; other site 272123010960 Walker B; other site 272123010961 D-loop; other site 272123010962 H-loop/switch region; other site 272123010963 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 272123010964 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272123010965 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 272123010966 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 272123010967 Bacterial SH3 domain; Region: SH3_3; cl17532 272123010968 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272123010969 putative active site [active] 272123010970 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272123010971 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272123010972 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 272123010973 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 272123010974 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 272123010975 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 272123010976 P-loop; other site 272123010977 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 272123010978 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 272123010979 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 272123010980 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123010981 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272123010982 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272123010983 Walker A/P-loop; other site 272123010984 ATP binding site [chemical binding]; other site 272123010985 Q-loop/lid; other site 272123010986 ABC transporter signature motif; other site 272123010987 Walker B; other site 272123010988 D-loop; other site 272123010989 H-loop/switch region; other site 272123010990 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272123010991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272123010992 ABC-ATPase subunit interface; other site 272123010993 dimer interface [polypeptide binding]; other site 272123010994 putative PBP binding regions; other site 272123010995 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 272123010996 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272123010997 putative ligand binding site [chemical binding]; other site 272123010998 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272123010999 dimer interface [polypeptide binding]; other site 272123011000 [2Fe-2S] cluster binding site [ion binding]; other site 272123011001 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 272123011002 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272123011003 N-terminal plug; other site 272123011004 ligand-binding site [chemical binding]; other site 272123011005 Predicted metal-binding protein [Function unknown]; Region: COG5469 272123011006 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 272123011007 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 272123011008 AMIN domain; Region: AMIN; pfam11741 272123011009 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272123011010 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272123011011 N-terminal plug; other site 272123011012 ligand-binding site [chemical binding]; other site 272123011013 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123011014 Homeodomain-like domain; Region: HTH_23; pfam13384 272123011015 Winged helix-turn helix; Region: HTH_29; pfam13551 272123011016 Winged helix-turn helix; Region: HTH_33; pfam13592 272123011017 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123011018 ligand binding site [chemical binding]; other site 272123011019 flexible hinge region; other site 272123011020 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123011021 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272123011022 putative active site [active] 272123011023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123011024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123011025 Walker A/P-loop; other site 272123011026 ATP binding site [chemical binding]; other site 272123011027 Q-loop/lid; other site 272123011028 ABC transporter signature motif; other site 272123011029 Walker B; other site 272123011030 D-loop; other site 272123011031 H-loop/switch region; other site 272123011032 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272123011033 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272123011034 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123011035 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272123011036 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 272123011037 Phosphotransferase enzyme family; Region: APH; pfam01636 272123011038 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272123011039 substrate binding site [chemical binding]; other site 272123011040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123011041 active site 272123011042 catalytic tetrad [active] 272123011043 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272123011044 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272123011045 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 272123011046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123011047 FeS/SAM binding site; other site 272123011048 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272123011049 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 272123011050 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 272123011051 Archaeal ATPase; Region: Arch_ATPase; pfam01637 272123011052 AAA ATPase domain; Region: AAA_16; pfam13191 272123011053 TolA protein; Region: tolA_full; TIGR02794 272123011054 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123011055 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123011056 structural tetrad; other site 272123011057 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272123011058 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272123011059 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123011060 active site 272123011061 metal binding site [ion binding]; metal-binding site 272123011062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 272123011063 FIST N domain; Region: FIST; pfam08495 272123011064 FIST C domain; Region: FIST_C; pfam10442 272123011065 CP12 domain; Region: CP12; pfam02672 272123011066 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 272123011067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272123011068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272123011069 sequence-specific DNA binding site [nucleotide binding]; other site 272123011070 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123011071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123011072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123011073 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 272123011074 GMP synthase; Reviewed; Region: guaA; PRK00074 272123011075 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272123011076 AMP/PPi binding site [chemical binding]; other site 272123011077 candidate oxyanion hole; other site 272123011078 catalytic triad [active] 272123011079 potential glutamine specificity residues [chemical binding]; other site 272123011080 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272123011081 ATP Binding subdomain [chemical binding]; other site 272123011082 Ligand Binding sites [chemical binding]; other site 272123011083 Dimerization subdomain; other site 272123011084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011086 active site 272123011087 phosphorylation site [posttranslational modification] 272123011088 intermolecular recognition site; other site 272123011089 dimerization interface [polypeptide binding]; other site 272123011090 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123011091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011092 putative active site [active] 272123011093 heme pocket [chemical binding]; other site 272123011094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011095 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123011096 putative active site [active] 272123011097 heme pocket [chemical binding]; other site 272123011098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011099 putative active site [active] 272123011100 heme pocket [chemical binding]; other site 272123011101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011103 dimer interface [polypeptide binding]; other site 272123011104 phosphorylation site [posttranslational modification] 272123011105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011106 ATP binding site [chemical binding]; other site 272123011107 Mg2+ binding site [ion binding]; other site 272123011108 G-X-G motif; other site 272123011109 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011111 active site 272123011112 phosphorylation site [posttranslational modification] 272123011113 intermolecular recognition site; other site 272123011114 dimerization interface [polypeptide binding]; other site 272123011115 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 272123011116 GAF domain; Region: GAF; pfam01590 272123011117 Phytochrome region; Region: PHY; pfam00360 272123011118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011119 dimer interface [polypeptide binding]; other site 272123011120 phosphorylation site [posttranslational modification] 272123011121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011122 ATP binding site [chemical binding]; other site 272123011123 Mg2+ binding site [ion binding]; other site 272123011124 G-X-G motif; other site 272123011125 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011127 active site 272123011128 phosphorylation site [posttranslational modification] 272123011129 intermolecular recognition site; other site 272123011130 dimerization interface [polypeptide binding]; other site 272123011131 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272123011132 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272123011133 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 272123011134 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272123011135 Protein of unknown function (DUF751); Region: DUF751; pfam05421 272123011136 DNA adenine methylase (dam); Region: dam; TIGR00571 272123011137 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 272123011138 hypothetical protein; Provisional; Region: PRK04194 272123011139 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272123011140 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123011141 putative active site [active] 272123011142 Fic family protein [Function unknown]; Region: COG3177 272123011143 Fic/DOC family; Region: Fic; pfam02661 272123011144 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 272123011145 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 272123011146 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272123011147 substrate binding site [chemical binding]; other site 272123011148 active site 272123011149 catalytic residues [active] 272123011150 heterodimer interface [polypeptide binding]; other site 272123011151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123011152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123011153 active site 272123011154 ATP binding site [chemical binding]; other site 272123011155 substrate binding site [chemical binding]; other site 272123011156 activation loop (A-loop); other site 272123011157 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 272123011158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123011159 ABC transporter signature motif; other site 272123011160 Walker B; other site 272123011161 D-loop; other site 272123011162 H-loop/switch region; other site 272123011163 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272123011164 MgtE intracellular N domain; Region: MgtE_N; smart00924 272123011165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272123011166 Divalent cation transporter; Region: MgtE; pfam01769 272123011167 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272123011168 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272123011169 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272123011170 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 272123011171 putative active site [active] 272123011172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123011173 AAA domain; Region: AAA_21; pfam13304 272123011174 Walker A/P-loop; other site 272123011175 ATP binding site [chemical binding]; other site 272123011176 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 272123011177 phosphoglyceromutase; Provisional; Region: PRK05434 272123011178 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272123011179 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 272123011180 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 272123011181 active site 272123011182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272123011183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 272123011184 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 272123011185 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272123011186 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272123011187 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272123011188 Catalytic site [active] 272123011189 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 272123011190 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 272123011191 Short C-terminal domain; Region: SHOCT; pfam09851 272123011192 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 272123011193 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123011194 HSP70 interaction site [polypeptide binding]; other site 272123011195 TPR repeat; Region: TPR_11; pfam13414 272123011196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123011197 binding surface 272123011198 TPR motif; other site 272123011199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123011201 TPR motif; other site 272123011202 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011203 binding surface 272123011204 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011205 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123011208 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 272123011209 Cysteine-rich domain; Region: CCG; pfam02754 272123011210 Cysteine-rich domain; Region: CCG; pfam02754 272123011211 acyl carrier protein; Provisional; Region: acpP; PRK00982 272123011212 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272123011213 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272123011214 dimer interface [polypeptide binding]; other site 272123011215 active site 272123011216 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272123011217 transketolase; Region: PLN02790 272123011218 TPP-binding site [chemical binding]; other site 272123011219 dimer interface [polypeptide binding]; other site 272123011220 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272123011221 PYR/PP interface [polypeptide binding]; other site 272123011222 dimer interface [polypeptide binding]; other site 272123011223 TPP binding site [chemical binding]; other site 272123011224 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272123011225 PAS fold; Region: PAS_4; pfam08448 272123011226 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011227 GAF domain; Region: GAF; pfam01590 272123011228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011229 GAF domain; Region: GAF; pfam01590 272123011230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011232 dimer interface [polypeptide binding]; other site 272123011233 phosphorylation site [posttranslational modification] 272123011234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011235 ATP binding site [chemical binding]; other site 272123011236 Mg2+ binding site [ion binding]; other site 272123011237 G-X-G motif; other site 272123011238 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011240 active site 272123011241 phosphorylation site [posttranslational modification] 272123011242 intermolecular recognition site; other site 272123011243 dimerization interface [polypeptide binding]; other site 272123011244 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011246 active site 272123011247 phosphorylation site [posttranslational modification] 272123011248 intermolecular recognition site; other site 272123011249 dimerization interface [polypeptide binding]; other site 272123011250 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123011251 putative binding surface; other site 272123011252 active site 272123011253 CHASE domain; Region: CHASE; cl01369 272123011254 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011255 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123011256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011258 dimer interface [polypeptide binding]; other site 272123011259 phosphorylation site [posttranslational modification] 272123011260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011261 ATP binding site [chemical binding]; other site 272123011262 Mg2+ binding site [ion binding]; other site 272123011263 G-X-G motif; other site 272123011264 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011266 active site 272123011267 phosphorylation site [posttranslational modification] 272123011268 intermolecular recognition site; other site 272123011269 dimerization interface [polypeptide binding]; other site 272123011270 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011272 active site 272123011273 phosphorylation site [posttranslational modification] 272123011274 intermolecular recognition site; other site 272123011275 dimerization interface [polypeptide binding]; other site 272123011276 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011278 active site 272123011279 phosphorylation site [posttranslational modification] 272123011280 intermolecular recognition site; other site 272123011281 dimerization interface [polypeptide binding]; other site 272123011282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011283 dimer interface [polypeptide binding]; other site 272123011284 phosphorylation site [posttranslational modification] 272123011285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011286 ATP binding site [chemical binding]; other site 272123011287 Mg2+ binding site [ion binding]; other site 272123011288 G-X-G motif; other site 272123011289 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123011290 FOG: CBS domain [General function prediction only]; Region: COG0517 272123011291 FOG: CBS domain [General function prediction only]; Region: COG0517 272123011292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 272123011293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011294 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123011295 PAS domain S-box; Region: sensory_box; TIGR00229 272123011296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011297 putative active site [active] 272123011298 heme pocket [chemical binding]; other site 272123011299 PAS domain S-box; Region: sensory_box; TIGR00229 272123011300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011301 putative active site [active] 272123011302 heme pocket [chemical binding]; other site 272123011303 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123011304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011305 putative active site [active] 272123011306 heme pocket [chemical binding]; other site 272123011307 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123011308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011309 putative active site [active] 272123011310 heme pocket [chemical binding]; other site 272123011311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011312 putative active site [active] 272123011313 heme pocket [chemical binding]; other site 272123011314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011315 PAS fold; Region: PAS_3; pfam08447 272123011316 putative active site [active] 272123011317 heme pocket [chemical binding]; other site 272123011318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011320 dimer interface [polypeptide binding]; other site 272123011321 phosphorylation site [posttranslational modification] 272123011322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011323 ATP binding site [chemical binding]; other site 272123011324 Mg2+ binding site [ion binding]; other site 272123011325 G-X-G motif; other site 272123011326 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011328 active site 272123011329 phosphorylation site [posttranslational modification] 272123011330 intermolecular recognition site; other site 272123011331 dimerization interface [polypeptide binding]; other site 272123011332 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011334 active site 272123011335 phosphorylation site [posttranslational modification] 272123011336 intermolecular recognition site; other site 272123011337 dimerization interface [polypeptide binding]; other site 272123011338 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 272123011339 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 272123011340 S-layer homology domain; Region: SLH; pfam00395 272123011341 S-layer homology domain; Region: SLH; pfam00395 272123011342 hypothetical protein; Provisional; Region: PRK05409 272123011343 TIGR04222 domain; Region: near_uncomplex 272123011344 Ion transport protein; Region: Ion_trans; pfam00520 272123011345 Ion channel; Region: Ion_trans_2; pfam07885 272123011346 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272123011347 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272123011348 nucleoside/Zn binding site; other site 272123011349 dimer interface [polypeptide binding]; other site 272123011350 catalytic motif [active] 272123011351 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 272123011352 heme-binding site [chemical binding]; other site 272123011353 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 272123011354 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272123011355 G1 box; other site 272123011356 GTP/Mg2+ binding site [chemical binding]; other site 272123011357 G2 box; other site 272123011358 Switch I region; other site 272123011359 G3 box; other site 272123011360 Switch II region; other site 272123011361 G4 box; other site 272123011362 G5 box; other site 272123011363 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 272123011364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123011365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011366 active site 272123011367 phosphorylation site [posttranslational modification] 272123011368 intermolecular recognition site; other site 272123011369 dimerization interface [polypeptide binding]; other site 272123011370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123011371 DNA binding residues [nucleotide binding] 272123011372 dimerization interface [polypeptide binding]; other site 272123011373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272123011374 Histidine kinase; Region: HisKA_3; pfam07730 272123011375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011376 ATP binding site [chemical binding]; other site 272123011377 Mg2+ binding site [ion binding]; other site 272123011378 G-X-G motif; other site 272123011379 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 272123011380 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 272123011381 putative efflux protein, MATE family; Region: matE; TIGR00797 272123011382 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 272123011383 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272123011384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123011385 catalytic triad [active] 272123011386 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 272123011387 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 272123011388 CheB methylesterase; Region: CheB_methylest; pfam01339 272123011389 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272123011390 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272123011391 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272123011392 PAS fold; Region: PAS_4; pfam08448 272123011393 PAS domain; Region: PAS; smart00091 272123011394 PAS domain; Region: PAS_9; pfam13426 272123011395 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 272123011396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123011397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011398 active site 272123011399 phosphorylation site [posttranslational modification] 272123011400 intermolecular recognition site; other site 272123011401 dimerization interface [polypeptide binding]; other site 272123011402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123011403 DNA binding site [nucleotide binding] 272123011404 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123011405 putative binding surface; other site 272123011406 active site 272123011407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011408 active site 272123011409 phosphorylation site [posttranslational modification] 272123011410 intermolecular recognition site; other site 272123011411 dimerization interface [polypeptide binding]; other site 272123011412 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011414 active site 272123011415 phosphorylation site [posttranslational modification] 272123011416 intermolecular recognition site; other site 272123011417 dimerization interface [polypeptide binding]; other site 272123011418 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272123011419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011420 PAS fold; Region: PAS_3; pfam08447 272123011421 putative active site [active] 272123011422 heme pocket [chemical binding]; other site 272123011423 PAS domain; Region: PAS; smart00091 272123011424 PAS domain; Region: PAS_9; pfam13426 272123011425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011426 putative active site [active] 272123011427 heme pocket [chemical binding]; other site 272123011428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123011429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011430 putative active site [active] 272123011431 heme pocket [chemical binding]; other site 272123011432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011433 dimer interface [polypeptide binding]; other site 272123011434 phosphorylation site [posttranslational modification] 272123011435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011436 ATP binding site [chemical binding]; other site 272123011437 Mg2+ binding site [ion binding]; other site 272123011438 G-X-G motif; other site 272123011439 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011441 active site 272123011442 phosphorylation site [posttranslational modification] 272123011443 intermolecular recognition site; other site 272123011444 dimerization interface [polypeptide binding]; other site 272123011445 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011447 active site 272123011448 phosphorylation site [posttranslational modification] 272123011449 intermolecular recognition site; other site 272123011450 dimerization interface [polypeptide binding]; other site 272123011451 phosphoenolpyruvate synthase; Validated; Region: PRK06464 272123011452 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272123011453 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272123011454 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272123011455 FOG: CBS domain [General function prediction only]; Region: COG0517 272123011456 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 272123011457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011458 PAS domain; Region: PAS_9; pfam13426 272123011459 putative active site [active] 272123011460 heme pocket [chemical binding]; other site 272123011461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011462 PAS fold; Region: PAS_3; pfam08447 272123011463 putative active site [active] 272123011464 heme pocket [chemical binding]; other site 272123011465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011466 PAS fold; Region: PAS_3; pfam08447 272123011467 putative active site [active] 272123011468 heme pocket [chemical binding]; other site 272123011469 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123011470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011471 putative active site [active] 272123011472 heme pocket [chemical binding]; other site 272123011473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011474 dimer interface [polypeptide binding]; other site 272123011475 phosphorylation site [posttranslational modification] 272123011476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011477 ATP binding site [chemical binding]; other site 272123011478 Mg2+ binding site [ion binding]; other site 272123011479 G-X-G motif; other site 272123011480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011482 active site 272123011483 phosphorylation site [posttranslational modification] 272123011484 intermolecular recognition site; other site 272123011485 dimerization interface [polypeptide binding]; other site 272123011486 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 272123011487 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 272123011488 putative active site [active] 272123011489 putative FMN binding site [chemical binding]; other site 272123011490 putative substrate binding site [chemical binding]; other site 272123011491 Putative phosphatase (DUF442); Region: DUF442; cl17385 272123011492 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 272123011493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272123011494 WYL domain; Region: WYL; cl14852 272123011495 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 272123011496 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 272123011497 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 272123011498 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123011499 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 272123011500 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 272123011501 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123011502 putative active site [active] 272123011503 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123011504 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123011505 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 272123011506 sucrose synthase; Region: sucr_synth; TIGR02470 272123011507 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272123011508 putative ADP-binding pocket [chemical binding]; other site 272123011509 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272123011510 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272123011511 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272123011512 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272123011513 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272123011514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123011515 Src Homology 3 domain superfamily; Region: SH3; cl17036 272123011516 XisI protein; Region: XisI; pfam08869 272123011517 XisH protein; Region: XisH; pfam08814 272123011518 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123011519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123011520 putative substrate translocation pore; other site 272123011521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272123011522 MarR family; Region: MarR; pfam01047 272123011523 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272123011524 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272123011525 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272123011526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123011527 Walker A/P-loop; other site 272123011528 ATP binding site [chemical binding]; other site 272123011529 Q-loop/lid; other site 272123011530 ABC transporter signature motif; other site 272123011531 Walker B; other site 272123011532 D-loop; other site 272123011533 H-loop/switch region; other site 272123011534 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011535 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123011536 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011537 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011538 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011539 YcfA-like protein; Region: YcfA; cl00752 272123011540 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123011541 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272123011542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272123011543 molybdopterin cofactor binding site; other site 272123011544 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 272123011545 molybdopterin cofactor binding site; other site 272123011546 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 272123011547 CoA binding domain; Region: CoA_binding_2; pfam13380 272123011548 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 272123011549 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 272123011550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272123011551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123011552 Coenzyme A binding pocket [chemical binding]; other site 272123011553 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 272123011554 nickel binding site [ion binding]; other site 272123011555 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123011556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011557 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123011559 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 272123011560 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 272123011561 FOG: CBS domain [General function prediction only]; Region: COG0517 272123011562 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 272123011563 CP12 domain; Region: CP12; pfam02672 272123011564 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 272123011565 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272123011566 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 272123011567 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 272123011568 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123011569 catalytic loop [active] 272123011570 iron binding site [ion binding]; other site 272123011571 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272123011572 4Fe-4S binding domain; Region: Fer4; pfam00037 272123011573 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272123011574 dimer interface [polypeptide binding]; other site 272123011575 [2Fe-2S] cluster binding site [ion binding]; other site 272123011576 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272123011577 SLBB domain; Region: SLBB; pfam10531 272123011578 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 272123011579 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 272123011580 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272123011581 putative dimer interface [polypeptide binding]; other site 272123011582 [2Fe-2S] cluster binding site [ion binding]; other site 272123011583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123011584 Ligand Binding Site [chemical binding]; other site 272123011585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123011586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123011587 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272123011588 Walker A/P-loop; other site 272123011589 ATP binding site [chemical binding]; other site 272123011590 Q-loop/lid; other site 272123011591 ABC transporter signature motif; other site 272123011592 Walker B; other site 272123011593 D-loop; other site 272123011594 H-loop/switch region; other site 272123011595 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272123011596 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272123011597 siderophore binding site; other site 272123011598 AMIN domain; Region: AMIN; pfam11741 272123011599 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272123011600 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272123011601 N-terminal plug; other site 272123011602 ligand-binding site [chemical binding]; other site 272123011603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272123011604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123011605 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123011606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011607 active site 272123011608 phosphorylation site [posttranslational modification] 272123011609 intermolecular recognition site; other site 272123011610 dimerization interface [polypeptide binding]; other site 272123011611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123011612 DNA binding site [nucleotide binding] 272123011613 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123011614 putative binding surface; other site 272123011615 active site 272123011616 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011618 active site 272123011619 phosphorylation site [posttranslational modification] 272123011620 intermolecular recognition site; other site 272123011621 dimerization interface [polypeptide binding]; other site 272123011622 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011624 active site 272123011625 phosphorylation site [posttranslational modification] 272123011626 intermolecular recognition site; other site 272123011627 dimerization interface [polypeptide binding]; other site 272123011628 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011629 GAF domain; Region: GAF; pfam01590 272123011630 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123011631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011632 putative active site [active] 272123011633 heme pocket [chemical binding]; other site 272123011634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011635 dimer interface [polypeptide binding]; other site 272123011636 phosphorylation site [posttranslational modification] 272123011637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011638 ATP binding site [chemical binding]; other site 272123011639 Mg2+ binding site [ion binding]; other site 272123011640 G-X-G motif; other site 272123011641 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011643 active site 272123011644 phosphorylation site [posttranslational modification] 272123011645 intermolecular recognition site; other site 272123011646 dimerization interface [polypeptide binding]; other site 272123011647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011648 active site 272123011649 phosphorylation site [posttranslational modification] 272123011650 intermolecular recognition site; other site 272123011651 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011652 dimerization interface [polypeptide binding]; other site 272123011653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123011654 S-adenosylmethionine binding site [chemical binding]; other site 272123011655 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 272123011656 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 272123011657 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272123011658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123011659 Response regulator receiver domain; Region: Response_reg; pfam00072 272123011660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011661 active site 272123011662 phosphorylation site [posttranslational modification] 272123011663 intermolecular recognition site; other site 272123011664 dimerization interface [polypeptide binding]; other site 272123011665 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 272123011666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123011667 non-specific DNA binding site [nucleotide binding]; other site 272123011668 salt bridge; other site 272123011669 sequence-specific DNA binding site [nucleotide binding]; other site 272123011670 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 272123011671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123011672 Walker A/P-loop; other site 272123011673 ATP binding site [chemical binding]; other site 272123011674 Q-loop/lid; other site 272123011675 ABC transporter signature motif; other site 272123011676 Walker B; other site 272123011677 D-loop; other site 272123011678 H-loop/switch region; other site 272123011679 DevC protein; Region: devC; TIGR01185 272123011680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123011681 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123011682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123011683 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123011684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272123011685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272123011686 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272123011687 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272123011688 protein binding site [polypeptide binding]; other site 272123011689 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272123011690 LabA_like proteins; Region: LabA; cd10911 272123011691 putative metal binding site [ion binding]; other site 272123011692 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123011693 Ligand Binding Site [chemical binding]; other site 272123011694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123011695 active site 272123011696 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 272123011697 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272123011698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123011699 dimerization interface [polypeptide binding]; other site 272123011700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011702 dimer interface [polypeptide binding]; other site 272123011703 phosphorylation site [posttranslational modification] 272123011704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011705 ATP binding site [chemical binding]; other site 272123011706 Mg2+ binding site [ion binding]; other site 272123011707 G-X-G motif; other site 272123011708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 272123011709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 272123011710 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 272123011711 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 272123011712 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123011713 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123011714 structural tetrad; other site 272123011715 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123011716 HSP70 interaction site [polypeptide binding]; other site 272123011717 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272123011718 Domain of unknown function DUF21; Region: DUF21; pfam01595 272123011719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272123011720 Transporter associated domain; Region: CorC_HlyC; smart01091 272123011721 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272123011722 Ligand Binding Site [chemical binding]; other site 272123011723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123011724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123011725 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272123011726 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272123011727 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272123011728 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272123011729 Mg binding site [ion binding]; other site 272123011730 nucleotide binding site [chemical binding]; other site 272123011731 putative protofilament interface [polypeptide binding]; other site 272123011732 CAAX protease self-immunity; Region: Abi; pfam02517 272123011733 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 272123011734 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123011735 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123011736 catalytic loop [active] 272123011737 iron binding site [ion binding]; other site 272123011738 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 272123011739 M28 Zn-Peptidases; Region: M28_like_1; cd05640 272123011740 Peptidase family M28; Region: Peptidase_M28; pfam04389 272123011741 metal binding site [ion binding]; metal-binding site 272123011742 molecular chaperone DnaK; Provisional; Region: PRK13410 272123011743 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272123011744 nucleotide binding site [chemical binding]; other site 272123011745 NEF interaction site [polypeptide binding]; other site 272123011746 SBD interface [polypeptide binding]; other site 272123011747 chaperone protein DnaJ; Provisional; Region: PRK14277 272123011748 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123011749 HSP70 interaction site [polypeptide binding]; other site 272123011750 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272123011751 substrate binding site [polypeptide binding]; other site 272123011752 dimer interface [polypeptide binding]; other site 272123011753 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272123011754 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123011755 HSP70 interaction site [polypeptide binding]; other site 272123011756 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 272123011757 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 272123011758 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 272123011759 catalytic residue [active] 272123011760 putative FPP diphosphate binding site; other site 272123011761 putative FPP binding hydrophobic cleft; other site 272123011762 dimer interface [polypeptide binding]; other site 272123011763 putative IPP diphosphate binding site; other site 272123011764 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272123011765 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272123011766 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272123011767 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272123011768 active site 272123011769 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272123011770 substrate binding site [chemical binding]; other site 272123011771 catalytic residues [active] 272123011772 dimer interface [polypeptide binding]; other site 272123011773 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272123011774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123011775 Coenzyme A binding pocket [chemical binding]; other site 272123011776 Clp protease ATP binding subunit; Region: clpC; CHL00095 272123011777 Clp amino terminal domain; Region: Clp_N; pfam02861 272123011778 Clp amino terminal domain; Region: Clp_N; pfam02861 272123011779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123011780 Walker A motif; other site 272123011781 ATP binding site [chemical binding]; other site 272123011782 Walker B motif; other site 272123011783 arginine finger; other site 272123011784 UvrB/uvrC motif; Region: UVR; pfam02151 272123011785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123011786 Walker A motif; other site 272123011787 ATP binding site [chemical binding]; other site 272123011788 Walker B motif; other site 272123011789 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272123011790 cobalamin synthase; Reviewed; Region: cobS; PRK00235 272123011791 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272123011792 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272123011793 Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533 272123011794 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272123011795 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272123011796 catalytic loop [active] 272123011797 iron binding site [ion binding]; other site 272123011798 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 272123011799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123011800 Ligand Binding Site [chemical binding]; other site 272123011801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123011802 Ligand Binding Site [chemical binding]; other site 272123011803 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123011804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123011805 active site 272123011806 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272123011807 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 272123011808 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272123011809 CHAT domain; Region: CHAT; pfam12770 272123011810 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 272123011811 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123011812 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123011813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123011815 binding surface 272123011816 TPR motif; other site 272123011817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123011819 binding surface 272123011820 TPR motif; other site 272123011821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011822 TPR repeat; Region: TPR_11; pfam13414 272123011823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123011824 binding surface 272123011825 TPR motif; other site 272123011826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123011828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123011829 binding surface 272123011830 TPR motif; other site 272123011831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123011832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123011833 active site 272123011834 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 272123011835 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272123011836 active site 272123011837 Zn binding site [ion binding]; other site 272123011838 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272123011839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272123011840 acylphosphatase; Provisional; Region: PRK14423 272123011841 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 272123011842 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 272123011843 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 272123011844 glycogen binding site [chemical binding]; other site 272123011845 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 272123011846 active site 272123011847 catalytic site [active] 272123011848 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272123011849 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 272123011850 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272123011851 cyanophycin synthetase; Provisional; Region: PRK14016 272123011852 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 272123011853 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272123011854 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272123011855 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 272123011856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123011857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011858 active site 272123011859 phosphorylation site [posttranslational modification] 272123011860 intermolecular recognition site; other site 272123011861 dimerization interface [polypeptide binding]; other site 272123011862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123011863 DNA binding site [nucleotide binding] 272123011864 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 272123011865 Predicted transcriptional regulator [Transcription]; Region: COG3905 272123011866 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123011867 XisI protein; Region: XisI; pfam08869 272123011868 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 272123011869 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272123011870 NAD(P) binding pocket [chemical binding]; other site 272123011871 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272123011872 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272123011873 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272123011874 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 272123011875 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 272123011876 Walker A motif; other site 272123011877 ATP binding site [chemical binding]; other site 272123011878 Walker B motif; other site 272123011879 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272123011880 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272123011881 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272123011882 Walker A motif; other site 272123011883 ATP binding site [chemical binding]; other site 272123011884 Walker B motif; other site 272123011885 GrpE; Region: GrpE; pfam01025 272123011886 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272123011887 dimer interface [polypeptide binding]; other site 272123011888 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272123011889 molecular chaperone DnaK; Provisional; Region: PRK13411 272123011890 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272123011891 nucleotide binding site [chemical binding]; other site 272123011892 NEF interaction site [polypeptide binding]; other site 272123011893 SBD interface [polypeptide binding]; other site 272123011894 chaperone protein DnaJ; Provisional; Region: PRK14293 272123011895 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123011896 HSP70 interaction site [polypeptide binding]; other site 272123011897 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272123011898 Zn binding sites [ion binding]; other site 272123011899 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272123011900 dimer interface [polypeptide binding]; other site 272123011901 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 272123011902 CPxP motif; other site 272123011903 GTPase RsgA; Reviewed; Region: PRK12289 272123011904 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272123011905 RNA binding site [nucleotide binding]; other site 272123011906 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272123011907 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272123011908 GTP/Mg2+ binding site [chemical binding]; other site 272123011909 G4 box; other site 272123011910 G5 box; other site 272123011911 G1 box; other site 272123011912 Switch I region; other site 272123011913 G2 box; other site 272123011914 G3 box; other site 272123011915 Switch II region; other site 272123011916 Uncharacterized conserved protein [Function unknown]; Region: COG1543 272123011917 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 272123011918 active site 272123011919 substrate binding site [chemical binding]; other site 272123011920 catalytic site [active] 272123011921 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 272123011922 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123011923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123011924 active site 272123011925 ATP binding site [chemical binding]; other site 272123011926 substrate binding site [chemical binding]; other site 272123011927 activation loop (A-loop); other site 272123011928 GUN4-like; Region: GUN4; pfam05419 272123011929 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272123011930 Domain of unknown function DUF21; Region: DUF21; pfam01595 272123011931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272123011932 amidase; Provisional; Region: PRK09201 272123011933 Amidase; Region: Amidase; cl11426 272123011934 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 272123011935 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 272123011936 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123011937 catalytic residues [active] 272123011938 glutaminase; Provisional; Region: PRK00971 272123011939 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 272123011940 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 272123011941 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 272123011942 Transposase IS200 like; Region: Y1_Tnp; cl00848 272123011943 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272123011944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123011945 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272123011946 Glycoprotease family; Region: Peptidase_M22; pfam00814 272123011947 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 272123011948 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272123011949 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272123011950 active site 272123011951 NTP binding site [chemical binding]; other site 272123011952 metal binding triad [ion binding]; metal-binding site 272123011953 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272123011954 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272123011955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011956 PAS domain; Region: PAS_9; pfam13426 272123011957 putative active site [active] 272123011958 heme pocket [chemical binding]; other site 272123011959 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123011960 GAF domain; Region: GAF; pfam01590 272123011961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011962 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123011963 putative active site [active] 272123011964 heme pocket [chemical binding]; other site 272123011965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123011966 putative active site [active] 272123011967 heme pocket [chemical binding]; other site 272123011968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123011969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123011970 dimer interface [polypeptide binding]; other site 272123011971 phosphorylation site [posttranslational modification] 272123011972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123011973 ATP binding site [chemical binding]; other site 272123011974 Mg2+ binding site [ion binding]; other site 272123011975 G-X-G motif; other site 272123011976 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123011977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123011978 active site 272123011979 phosphorylation site [posttranslational modification] 272123011980 intermolecular recognition site; other site 272123011981 dimerization interface [polypeptide binding]; other site 272123011982 16S rRNA methyltransferase B; Provisional; Region: PRK14901 272123011983 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272123011984 putative RNA binding site [nucleotide binding]; other site 272123011985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123011986 S-adenosylmethionine binding site [chemical binding]; other site 272123011987 tellurium resistance terB-like protein; Region: terB_like; cd07177 272123011988 metal binding site [ion binding]; metal-binding site 272123011989 Transglycosylase; Region: Transgly; pfam00912 272123011990 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272123011991 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272123011992 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272123011993 catalytic center binding site [active] 272123011994 ATP binding site [chemical binding]; other site 272123011995 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 272123011996 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272123011997 dimer interface [polypeptide binding]; other site 272123011998 ADP-ribose binding site [chemical binding]; other site 272123011999 active site 272123012000 nudix motif; other site 272123012001 metal binding site [ion binding]; metal-binding site 272123012002 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258 272123012003 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272123012004 Walker A/P-loop; other site 272123012005 ATP binding site [chemical binding]; other site 272123012006 Q-loop/lid; other site 272123012007 ABC transporter signature motif; other site 272123012008 Walker B; other site 272123012009 D-loop; other site 272123012010 H-loop/switch region; other site 272123012011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012013 dimer interface [polypeptide binding]; other site 272123012014 phosphorylation site [posttranslational modification] 272123012015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012016 ATP binding site [chemical binding]; other site 272123012017 Mg2+ binding site [ion binding]; other site 272123012018 G-X-G motif; other site 272123012019 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272123012020 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272123012021 putative active site [active] 272123012022 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 272123012023 Family of unknown function (DUF490); Region: DUF490; pfam04357 272123012024 Predicted membrane protein [Function unknown]; Region: COG3650 272123012025 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123012026 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123012027 ligand binding site [chemical binding]; other site 272123012028 flexible hinge region; other site 272123012029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012031 ATP binding site [chemical binding]; other site 272123012032 Mg2+ binding site [ion binding]; other site 272123012033 G-X-G motif; other site 272123012034 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272123012035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123012036 ligand binding site [chemical binding]; other site 272123012037 flexible hinge region; other site 272123012038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272123012039 phosphorylation site [posttranslational modification] 272123012040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012042 ATP binding site [chemical binding]; other site 272123012043 Mg2+ binding site [ion binding]; other site 272123012044 G-X-G motif; other site 272123012045 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123012046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012047 active site 272123012048 phosphorylation site [posttranslational modification] 272123012049 intermolecular recognition site; other site 272123012050 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272123012051 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272123012052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123012053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123012054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012055 dimer interface [polypeptide binding]; other site 272123012056 conserved gate region; other site 272123012057 putative PBP binding loops; other site 272123012058 ABC-ATPase subunit interface; other site 272123012059 Response regulator receiver domain; Region: Response_reg; pfam00072 272123012060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012061 active site 272123012062 phosphorylation site [posttranslational modification] 272123012063 intermolecular recognition site; other site 272123012064 dimerization interface [polypeptide binding]; other site 272123012065 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123012066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123012067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123012068 metal binding site [ion binding]; metal-binding site 272123012069 active site 272123012070 I-site; other site 272123012071 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 272123012072 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 272123012073 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272123012074 homodimer interface [polypeptide binding]; other site 272123012075 metal binding site [ion binding]; metal-binding site 272123012076 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272123012077 homodimer interface [polypeptide binding]; other site 272123012078 active site 272123012079 putative chemical substrate binding site [chemical binding]; other site 272123012080 metal binding site [ion binding]; metal-binding site 272123012081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272123012082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123012083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123012084 membrane-bound complex binding site; other site 272123012085 hinge residues; other site 272123012086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123012087 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 272123012088 LVIVD repeat; Region: LVIVD; pfam08309 272123012089 LVIVD repeat; Region: LVIVD; pfam08309 272123012090 LVIVD repeat; Region: LVIVD; pfam08309 272123012091 LVIVD repeat; Region: LVIVD; pfam08309 272123012092 LVIVD repeat; Region: LVIVD; pfam08309 272123012093 LVIVD repeat; Region: LVIVD; pfam08309 272123012094 LVIVD repeat; Region: LVIVD; pfam08309 272123012095 LVIVD repeat; Region: LVIVD; pfam08309 272123012096 LVIVD repeat; Region: LVIVD; pfam08309 272123012097 LVIVD repeat; Region: LVIVD; pfam08309 272123012098 LVIVD repeat; Region: LVIVD; pfam08309 272123012099 LVIVD repeat; Region: LVIVD; pfam08309 272123012100 LVIVD repeat; Region: LVIVD; pfam08309 272123012101 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123012102 Ca2+ binding site [ion binding]; other site 272123012103 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123012104 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272123012105 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272123012106 TrkA-N domain; Region: TrkA_N; pfam02254 272123012107 TrkA-C domain; Region: TrkA_C; pfam02080 272123012108 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 272123012109 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272123012110 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 272123012111 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272123012112 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272123012113 putative catalytic cysteine [active] 272123012114 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123012115 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272123012116 putative C-terminal domain interface [polypeptide binding]; other site 272123012117 putative GSH binding site (G-site) [chemical binding]; other site 272123012118 putative dimer interface [polypeptide binding]; other site 272123012119 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 272123012120 putative N-terminal domain interface [polypeptide binding]; other site 272123012121 putative dimer interface [polypeptide binding]; other site 272123012122 putative substrate binding pocket (H-site) [chemical binding]; other site 272123012123 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272123012124 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272123012125 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 272123012126 UbiA prenyltransferase family; Region: UbiA; pfam01040 272123012127 O-succinylbenzoate synthase; Provisional; Region: PRK02714 272123012128 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 272123012129 active site 272123012130 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 272123012131 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 272123012132 acyl-activating enzyme (AAE) consensus motif; other site 272123012133 putative AMP binding site [chemical binding]; other site 272123012134 putative active site [active] 272123012135 putative CoA binding site [chemical binding]; other site 272123012136 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272123012137 active site 272123012138 Phosphotransferase enzyme family; Region: APH; pfam01636 272123012139 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272123012140 active site 272123012141 ATP binding site [chemical binding]; other site 272123012142 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272123012143 substrate binding site [chemical binding]; other site 272123012144 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 272123012145 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 272123012146 Protein of unknown function (DUF815); Region: DUF815; pfam05673 272123012147 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272123012148 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272123012149 AAA ATPase domain; Region: AAA_16; pfam13191 272123012150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012151 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123012152 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012153 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123012154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012156 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012157 putative active site [active] 272123012158 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272123012159 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272123012160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123012161 Walker A motif; other site 272123012162 ATP binding site [chemical binding]; other site 272123012163 Walker B motif; other site 272123012164 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272123012165 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272123012166 RuvA N terminal domain; Region: RuvA_N; pfam01330 272123012167 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272123012168 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 272123012169 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272123012170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123012171 catalytic residue [active] 272123012172 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272123012173 AIR carboxylase; Region: AIRC; pfam00731 272123012174 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272123012175 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272123012176 active site 272123012177 dimer interface [polypeptide binding]; other site 272123012178 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123012179 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 272123012180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123012181 S-adenosylmethionine binding site [chemical binding]; other site 272123012182 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 272123012183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123012184 non-specific DNA binding site [nucleotide binding]; other site 272123012185 salt bridge; other site 272123012186 sequence-specific DNA binding site [nucleotide binding]; other site 272123012187 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272123012188 AAA ATPase domain; Region: AAA_15; pfam13175 272123012189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123012190 Q-loop/lid; other site 272123012191 ABC transporter signature motif; other site 272123012192 Walker B; other site 272123012193 D-loop; other site 272123012194 H-loop/switch region; other site 272123012195 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123012196 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272123012197 putative active site [active] 272123012198 homotetrameric interface [polypeptide binding]; other site 272123012199 metal binding site [ion binding]; metal-binding site 272123012200 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123012201 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123012202 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123012203 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123012204 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123012205 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123012206 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272123012207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123012208 putative Mg++ binding site [ion binding]; other site 272123012209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123012210 nucleotide binding region [chemical binding]; other site 272123012211 ATP-binding site [chemical binding]; other site 272123012212 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123012213 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012214 active site 272123012215 ATP binding site [chemical binding]; other site 272123012216 substrate binding site [chemical binding]; other site 272123012217 activation loop (A-loop); other site 272123012218 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 272123012219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012220 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123012221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123012222 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 272123012223 catalytic triad [active] 272123012224 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 272123012225 phosphoenolpyruvate synthase; Validated; Region: PRK06241 272123012226 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272123012227 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272123012228 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272123012229 NMT1-like family; Region: NMT1_2; pfam13379 272123012230 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272123012231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012232 dimer interface [polypeptide binding]; other site 272123012233 conserved gate region; other site 272123012234 putative PBP binding loops; other site 272123012235 ABC-ATPase subunit interface; other site 272123012236 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272123012237 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 272123012238 Walker A/P-loop; other site 272123012239 ATP binding site [chemical binding]; other site 272123012240 Q-loop/lid; other site 272123012241 ABC transporter signature motif; other site 272123012242 Walker B; other site 272123012243 D-loop; other site 272123012244 H-loop/switch region; other site 272123012245 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272123012246 NMT1-like family; Region: NMT1_2; pfam13379 272123012247 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272123012248 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 272123012249 Walker A/P-loop; other site 272123012250 ATP binding site [chemical binding]; other site 272123012251 Q-loop/lid; other site 272123012252 ABC transporter signature motif; other site 272123012253 Walker B; other site 272123012254 D-loop; other site 272123012255 H-loop/switch region; other site 272123012256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123012257 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272123012258 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272123012259 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272123012260 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272123012261 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272123012262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123012263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123012264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012265 binding surface 272123012266 TPR motif; other site 272123012267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123012268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012269 binding surface 272123012270 TPR motif; other site 272123012271 TPR repeat; Region: TPR_11; pfam13414 272123012272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012273 binding surface 272123012274 TPR motif; other site 272123012275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123012276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123012277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012278 TPR motif; other site 272123012279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 272123012280 Predicted ATPase [General function prediction only]; Region: COG4637 272123012281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123012282 Q-loop/lid; other site 272123012283 ABC transporter signature motif; other site 272123012284 Walker B; other site 272123012285 D-loop; other site 272123012286 H-loop/switch region; other site 272123012287 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272123012288 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272123012289 hinge; other site 272123012290 active site 272123012291 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272123012292 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272123012293 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272123012294 Staphylococcal nuclease homologues; Region: SNc; smart00318 272123012295 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272123012296 Catalytic site; other site 272123012297 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 272123012298 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 272123012299 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272123012300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123012301 active site 272123012302 motif I; other site 272123012303 motif II; other site 272123012304 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272123012305 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 272123012306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272123012307 Walker A/P-loop; other site 272123012308 ATP binding site [chemical binding]; other site 272123012309 Q-loop/lid; other site 272123012310 ABC transporter signature motif; other site 272123012311 Walker B; other site 272123012312 D-loop; other site 272123012313 H-loop/switch region; other site 272123012314 DevC protein; Region: devC; TIGR01185 272123012315 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272123012316 FtsX-like permease family; Region: FtsX; pfam02687 272123012317 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123012318 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123012319 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 272123012320 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 272123012321 active site 272123012322 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272123012323 active site 272123012324 NTP binding site [chemical binding]; other site 272123012325 metal binding triad [ion binding]; metal-binding site 272123012326 antibiotic binding site [chemical binding]; other site 272123012327 Maf-like protein; Region: Maf; pfam02545 272123012328 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272123012329 active site 272123012330 dimer interface [polypeptide binding]; other site 272123012331 PsbP; Region: PsbP; pfam01789 272123012332 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272123012333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272123012334 active site 272123012335 dimer interface [polypeptide binding]; other site 272123012336 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 272123012337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123012338 active site 272123012339 catalytic tetrad [active] 272123012340 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272123012341 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272123012342 iron-sulfur cluster [ion binding]; other site 272123012343 [2Fe-2S] cluster binding site [ion binding]; other site 272123012344 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 272123012345 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272123012346 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272123012347 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272123012348 purine monophosphate binding site [chemical binding]; other site 272123012349 dimer interface [polypeptide binding]; other site 272123012350 putative catalytic residues [active] 272123012351 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272123012352 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272123012353 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 272123012354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123012355 FeS/SAM binding site; other site 272123012356 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 272123012357 protein I interface; other site 272123012358 D2 interface; other site 272123012359 protein T interface; other site 272123012360 chlorophyll binding site; other site 272123012361 beta carotene binding site; other site 272123012362 pheophytin binding site; other site 272123012363 manganese-stabilizing polypeptide interface; other site 272123012364 CP43 interface; other site 272123012365 protein L interface; other site 272123012366 oxygen evolving complex binding site; other site 272123012367 bromide binding site; other site 272123012368 quinone binding site; other site 272123012369 Fe binding site [ion binding]; other site 272123012370 core light harvesting interface; other site 272123012371 cytochrome b559 alpha subunit interface; other site 272123012372 cytochrome c-550 interface; other site 272123012373 protein J interface; other site 272123012374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012375 putative active site [active] 272123012376 GUN4-like; Region: GUN4; pfam05419 272123012377 GUN4-like; Region: GUN4; pfam05419 272123012378 TPR repeat; Region: TPR_11; pfam13414 272123012379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012380 binding surface 272123012381 TPR motif; other site 272123012382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123012383 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123012384 hypothetical protein; Validated; Region: PRK07413 272123012385 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272123012386 Walker A motif; other site 272123012387 homodimer interface [polypeptide binding]; other site 272123012388 ATP binding site [chemical binding]; other site 272123012389 hydroxycobalamin binding site [chemical binding]; other site 272123012390 Walker B motif; other site 272123012391 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272123012392 Walker A motif; other site 272123012393 homodimer interface [polypeptide binding]; other site 272123012394 ATP binding site [chemical binding]; other site 272123012395 hydroxycobalamin binding site [chemical binding]; other site 272123012396 Walker B motif; other site 272123012397 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272123012398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012399 dimer interface [polypeptide binding]; other site 272123012400 conserved gate region; other site 272123012401 putative PBP binding loops; other site 272123012402 ABC-ATPase subunit interface; other site 272123012403 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272123012404 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272123012405 active site 272123012406 substrate binding site [chemical binding]; other site 272123012407 cosubstrate binding site; other site 272123012408 catalytic site [active] 272123012409 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272123012410 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 272123012411 active site 272123012412 substrate binding site [chemical binding]; other site 272123012413 metal binding site [ion binding]; metal-binding site 272123012414 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272123012415 active site 272123012416 dimerization interface [polypeptide binding]; other site 272123012417 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 272123012418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123012419 non-specific DNA binding site [nucleotide binding]; other site 272123012420 salt bridge; other site 272123012421 sequence-specific DNA binding site [nucleotide binding]; other site 272123012422 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 272123012423 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272123012424 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272123012425 CHAT domain; Region: CHAT; pfam12770 272123012426 acyl-CoA synthetase; Validated; Region: PRK05850 272123012427 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272123012428 acyl-activating enzyme (AAE) consensus motif; other site 272123012429 active site 272123012430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272123012431 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272123012432 active site 272123012433 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272123012434 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272123012435 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272123012436 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272123012437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123012438 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 272123012439 Protein of unknown function, DUF393; Region: DUF393; cl01136 272123012440 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 272123012441 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272123012442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123012443 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 272123012444 active site clefts [active] 272123012445 zinc binding site [ion binding]; other site 272123012446 dimer interface [polypeptide binding]; other site 272123012447 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 272123012448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123012449 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 272123012450 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 272123012451 putative active site [active] 272123012452 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 272123012453 active site 272123012454 catalytic triad [active] 272123012455 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 272123012456 PAS fold; Region: PAS_4; pfam08448 272123012457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012458 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 272123012459 dimer interface [polypeptide binding]; other site 272123012460 phosphorylation site [posttranslational modification] 272123012461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012462 ATP binding site [chemical binding]; other site 272123012463 Mg2+ binding site [ion binding]; other site 272123012464 G-X-G motif; other site 272123012465 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272123012466 dimer interface [polypeptide binding]; other site 272123012467 substrate binding site [chemical binding]; other site 272123012468 ATP binding site [chemical binding]; other site 272123012469 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272123012470 catalytic triad [active] 272123012471 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272123012472 30S subunit binding site; other site 272123012473 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272123012474 RNA-binding motif; other site 272123012475 DNA-binding site [nucleotide binding]; DNA binding site 272123012476 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 272123012477 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272123012478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272123012479 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272123012480 active site 272123012481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123012482 dimerization interface [polypeptide binding]; other site 272123012483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012484 dimer interface [polypeptide binding]; other site 272123012485 phosphorylation site [posttranslational modification] 272123012486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012487 ATP binding site [chemical binding]; other site 272123012488 Mg2+ binding site [ion binding]; other site 272123012489 G-X-G motif; other site 272123012490 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 272123012491 diiron binding motif [ion binding]; other site 272123012492 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012493 putative active site [active] 272123012494 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272123012495 YcfA-like protein; Region: YcfA; pfam07927 272123012496 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 272123012497 homodimer interface [polypeptide binding]; other site 272123012498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123012499 catalytic residue [active] 272123012500 HPP family; Region: HPP; pfam04982 272123012501 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 272123012502 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272123012503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123012504 putative ADP-binding pocket [chemical binding]; other site 272123012505 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272123012506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012507 dimer interface [polypeptide binding]; other site 272123012508 conserved gate region; other site 272123012509 putative PBP binding loops; other site 272123012510 ABC-ATPase subunit interface; other site 272123012511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272123012512 catalytic core [active] 272123012513 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123012514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012515 active site 272123012516 phosphorylation site [posttranslational modification] 272123012517 intermolecular recognition site; other site 272123012518 dimerization interface [polypeptide binding]; other site 272123012519 Response regulator receiver domain; Region: Response_reg; pfam00072 272123012520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012521 active site 272123012522 phosphorylation site [posttranslational modification] 272123012523 intermolecular recognition site; other site 272123012524 dimerization interface [polypeptide binding]; other site 272123012525 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123012526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012527 active site 272123012528 phosphorylation site [posttranslational modification] 272123012529 intermolecular recognition site; other site 272123012530 dimerization interface [polypeptide binding]; other site 272123012531 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123012532 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123012533 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123012534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123012535 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123012536 putative active site [active] 272123012537 heme pocket [chemical binding]; other site 272123012538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123012539 putative active site [active] 272123012540 heme pocket [chemical binding]; other site 272123012541 PAS fold; Region: PAS_4; pfam08448 272123012542 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123012543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123012544 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123012545 putative active site [active] 272123012546 heme pocket [chemical binding]; other site 272123012547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012548 dimer interface [polypeptide binding]; other site 272123012549 phosphorylation site [posttranslational modification] 272123012550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012551 ATP binding site [chemical binding]; other site 272123012552 Mg2+ binding site [ion binding]; other site 272123012553 G-X-G motif; other site 272123012554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123012555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012556 active site 272123012557 phosphorylation site [posttranslational modification] 272123012558 intermolecular recognition site; other site 272123012559 dimerization interface [polypeptide binding]; other site 272123012560 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 272123012561 GAF domain; Region: GAF; pfam01590 272123012562 Phytochrome region; Region: PHY; pfam00360 272123012563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012564 dimer interface [polypeptide binding]; other site 272123012565 phosphorylation site [posttranslational modification] 272123012566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012567 ATP binding site [chemical binding]; other site 272123012568 Mg2+ binding site [ion binding]; other site 272123012569 G-X-G motif; other site 272123012570 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123012571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012572 active site 272123012573 phosphorylation site [posttranslational modification] 272123012574 intermolecular recognition site; other site 272123012575 dimerization interface [polypeptide binding]; other site 272123012576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123012577 DNA binding site [nucleotide binding] 272123012578 Hpt domain; Region: Hpt; pfam01627 272123012579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012580 active site 272123012581 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 272123012582 phosphorylation site [posttranslational modification] 272123012583 intermolecular recognition site; other site 272123012584 dimerization interface [polypeptide binding]; other site 272123012585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123012586 active site 272123012587 phosphorylation site [posttranslational modification] 272123012588 intermolecular recognition site; other site 272123012589 dimerization interface [polypeptide binding]; other site 272123012590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123012591 metal binding site [ion binding]; metal-binding site 272123012592 active site 272123012593 I-site; other site 272123012594 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 272123012595 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272123012596 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272123012597 G1 box; other site 272123012598 putative GEF interaction site [polypeptide binding]; other site 272123012599 GTP/Mg2+ binding site [chemical binding]; other site 272123012600 Switch I region; other site 272123012601 G2 box; other site 272123012602 G3 box; other site 272123012603 Switch II region; other site 272123012604 G4 box; other site 272123012605 G5 box; other site 272123012606 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272123012607 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272123012608 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123012609 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012610 active site 272123012611 ATP binding site [chemical binding]; other site 272123012612 substrate binding site [chemical binding]; other site 272123012613 activation loop (A-loop); other site 272123012614 GUN4-like; Region: GUN4; pfam05419 272123012615 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272123012616 HD domain; Region: HD_4; pfam13328 272123012617 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 272123012618 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272123012619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123012620 active site 272123012621 Protein kinase domain; Region: Pkinase; pfam00069 272123012622 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012623 active site 272123012624 ATP binding site [chemical binding]; other site 272123012625 substrate binding site [chemical binding]; other site 272123012626 activation loop (A-loop); other site 272123012627 AAA domain; Region: AAA_26; pfam13500 272123012628 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 272123012629 Type II/IV secretion system protein; Region: T2SE; pfam00437 272123012630 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272123012631 Walker A motif; other site 272123012632 ATP binding site [chemical binding]; other site 272123012633 Walker B motif; other site 272123012634 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272123012635 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272123012636 metal binding site [ion binding]; metal-binding site 272123012637 dimer interface [polypeptide binding]; other site 272123012638 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 272123012639 proposed catalytic triad [active] 272123012640 active site nucleophile [active] 272123012641 cyanophycin synthetase; Provisional; Region: PRK14016 272123012642 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 272123012643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123012644 Walker A motif; other site 272123012645 ATP binding site [chemical binding]; other site 272123012646 Walker B motif; other site 272123012647 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 272123012648 protein-splicing catalytic site; other site 272123012649 thioester formation/cholesterol transfer; other site 272123012650 Pretoxin HINT domain; Region: PT-HINT; pfam07591 272123012651 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 272123012652 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272123012653 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272123012654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012655 binding surface 272123012656 TPR motif; other site 272123012657 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123012658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012659 binding surface 272123012660 TPR motif; other site 272123012661 Tetratricopeptide repeat; Region: TPR_1; pfam00515 272123012662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012663 binding surface 272123012664 TPR motif; other site 272123012665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012666 binding surface 272123012667 TPR motif; other site 272123012668 CHAT domain; Region: CHAT; cl17868 272123012669 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272123012670 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272123012671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123012672 ATP binding site [chemical binding]; other site 272123012673 putative Mg++ binding site [ion binding]; other site 272123012674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123012675 nucleotide binding region [chemical binding]; other site 272123012676 ATP-binding site [chemical binding]; other site 272123012677 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272123012678 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272123012679 Domain of unknown function DUF21; Region: DUF21; pfam01595 272123012680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272123012681 Transporter associated domain; Region: CorC_HlyC; smart01091 272123012682 FOG: CBS domain [General function prediction only]; Region: COG0517 272123012683 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 272123012684 CP12 domain; Region: CP12; pfam02672 272123012685 Predicted permeases [General function prediction only]; Region: COG0795 272123012686 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272123012687 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272123012688 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272123012689 Walker A/P-loop; other site 272123012690 ATP binding site [chemical binding]; other site 272123012691 Q-loop/lid; other site 272123012692 ABC transporter signature motif; other site 272123012693 Walker B; other site 272123012694 D-loop; other site 272123012695 H-loop/switch region; other site 272123012696 OstA-like protein; Region: OstA; cl00844 272123012697 Domain of unknown function (DUF309); Region: DUF309; pfam03745 272123012698 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 272123012699 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272123012700 Protein of unknown function DUF58; Region: DUF58; pfam01882 272123012701 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123012702 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272123012703 putative catalytic site [active] 272123012704 putative metal binding site [ion binding]; other site 272123012705 putative phosphate binding site [ion binding]; other site 272123012706 GDYXXLXY protein; Region: GDYXXLXY; cl02066 272123012707 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 272123012708 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 272123012709 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 272123012710 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123012711 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123012712 Integral membrane protein DUF92; Region: DUF92; pfam01940 272123012713 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272123012714 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272123012715 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272123012716 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123012717 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 272123012718 putative active site [active] 272123012719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123012720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123012721 Walker A/P-loop; other site 272123012722 ATP binding site [chemical binding]; other site 272123012723 Q-loop/lid; other site 272123012724 ABC transporter signature motif; other site 272123012725 Walker B; other site 272123012726 D-loop; other site 272123012727 H-loop/switch region; other site 272123012728 Peptidase family M48; Region: Peptidase_M48; cl12018 272123012729 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 272123012730 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272123012731 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272123012732 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272123012733 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272123012734 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272123012735 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 272123012736 Late competence development protein ComFB; Region: ComFB; pfam10719 272123012737 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 272123012738 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 272123012739 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 272123012740 putative active site [active] 272123012741 putative substrate binding site [chemical binding]; other site 272123012742 putative cosubstrate binding site; other site 272123012743 catalytic site [active] 272123012744 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 272123012745 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 272123012746 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 272123012747 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123012748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123012749 Walker A/P-loop; other site 272123012750 ATP binding site [chemical binding]; other site 272123012751 Q-loop/lid; other site 272123012752 ABC transporter signature motif; other site 272123012753 Walker B; other site 272123012754 D-loop; other site 272123012755 H-loop/switch region; other site 272123012756 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 272123012757 S-layer homology domain; Region: SLH; pfam00395 272123012758 S-layer homology domain; Region: SLH; pfam00395 272123012759 S-layer homology domain; Region: SLH; pfam00395 272123012760 S-layer homology domain; Region: SLH; pfam00395 272123012761 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 272123012762 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 272123012763 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272123012764 thiamine phosphate binding site [chemical binding]; other site 272123012765 active site 272123012766 pyrophosphate binding site [ion binding]; other site 272123012767 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272123012768 thiS-thiF/thiG interaction site; other site 272123012769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123012770 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 272123012771 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 272123012772 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 272123012773 active site 272123012774 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123012775 Ca2+ binding site [ion binding]; other site 272123012776 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012777 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123012778 active site 272123012779 ATP binding site [chemical binding]; other site 272123012780 substrate binding site [chemical binding]; other site 272123012781 activation loop (A-loop); other site 272123012782 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272123012783 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123012784 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 272123012785 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 272123012786 tandem repeat interface [polypeptide binding]; other site 272123012787 oligomer interface [polypeptide binding]; other site 272123012788 active site residues [active] 272123012789 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272123012790 tandem repeat interface [polypeptide binding]; other site 272123012791 oligomer interface [polypeptide binding]; other site 272123012792 active site residues [active] 272123012793 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272123012794 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272123012795 homotetramer interface [polypeptide binding]; other site 272123012796 FMN binding site [chemical binding]; other site 272123012797 homodimer contacts [polypeptide binding]; other site 272123012798 putative active site [active] 272123012799 putative substrate binding site [chemical binding]; other site 272123012800 Calx-beta domain; Region: Calx-beta; cl02522 272123012801 Calx-beta domain; Region: Calx-beta; cl02522 272123012802 Calx-beta domain; Region: Calx-beta; cl02522 272123012803 Calx-beta domain; Region: Calx-beta; cl02522 272123012804 Calx-beta domain; Region: Calx-beta; cl02522 272123012805 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272123012806 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 272123012807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123012808 dimerization interface [polypeptide binding]; other site 272123012809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012811 dimer interface [polypeptide binding]; other site 272123012812 phosphorylation site [posttranslational modification] 272123012813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012814 ATP binding site [chemical binding]; other site 272123012815 Mg2+ binding site [ion binding]; other site 272123012816 G-X-G motif; other site 272123012817 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 272123012818 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 272123012819 G1 box; other site 272123012820 GTP/Mg2+ binding site [chemical binding]; other site 272123012821 Switch I region; other site 272123012822 G2 box; other site 272123012823 Switch II region; other site 272123012824 G3 box; other site 272123012825 G4 box; other site 272123012826 G5 box; other site 272123012827 Domain of unknown function (DUF697); Region: DUF697; pfam05128 272123012828 Protein kinase domain; Region: Pkinase; pfam00069 272123012829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012830 active site 272123012831 ATP binding site [chemical binding]; other site 272123012832 substrate binding site [chemical binding]; other site 272123012833 activation loop (A-loop); other site 272123012834 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123012835 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123012836 active site 272123012837 ATP binding site [chemical binding]; other site 272123012838 substrate binding site [chemical binding]; other site 272123012839 activation loop (A-loop); other site 272123012840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012841 TPR repeat; Region: TPR_11; pfam13414 272123012842 binding surface 272123012843 TPR motif; other site 272123012844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012845 binding surface 272123012846 TPR motif; other site 272123012847 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123012848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012849 binding surface 272123012850 TPR motif; other site 272123012851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012852 binding surface 272123012853 TPR motif; other site 272123012854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123012855 binding surface 272123012856 TPR motif; other site 272123012857 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 272123012858 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 272123012859 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272123012860 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 272123012861 transmembrane helices; other site 272123012862 Universal stress protein family; Region: Usp; pfam00582 272123012863 Ligand Binding Site [chemical binding]; other site 272123012864 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272123012865 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 272123012866 Walker A/P-loop; other site 272123012867 ATP binding site [chemical binding]; other site 272123012868 Q-loop/lid; other site 272123012869 ABC transporter signature motif; other site 272123012870 Walker B; other site 272123012871 D-loop; other site 272123012872 H-loop/switch region; other site 272123012873 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272123012874 NMT1-like family; Region: NMT1_2; pfam13379 272123012875 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272123012876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012877 dimer interface [polypeptide binding]; other site 272123012878 conserved gate region; other site 272123012879 putative PBP binding loops; other site 272123012880 ABC-ATPase subunit interface; other site 272123012881 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 272123012882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123012883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123012884 dimer interface [polypeptide binding]; other site 272123012885 phosphorylation site [posttranslational modification] 272123012886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123012887 ATP binding site [chemical binding]; other site 272123012888 Mg2+ binding site [ion binding]; other site 272123012889 G-X-G motif; other site 272123012890 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 272123012891 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272123012892 dimerization interface [polypeptide binding]; other site 272123012893 active site 272123012894 metal binding site [ion binding]; metal-binding site 272123012895 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272123012896 dsRNA binding site [nucleotide binding]; other site 272123012897 XisH protein; Region: XisH; pfam08814 272123012898 XisI protein; Region: XisI; pfam08869 272123012899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012900 putative active site [active] 272123012901 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 272123012902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123012903 Walker A motif; other site 272123012904 ATP binding site [chemical binding]; other site 272123012905 Walker B motif; other site 272123012906 arginine finger; other site 272123012907 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 272123012908 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 272123012909 metal ion-dependent adhesion site (MIDAS); other site 272123012910 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 272123012911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123012912 Walker A/P-loop; other site 272123012913 ATP binding site [chemical binding]; other site 272123012914 AAA domain; Region: AAA_21; pfam13304 272123012915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272123012916 Walker B; other site 272123012917 D-loop; other site 272123012918 H-loop/switch region; other site 272123012919 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 272123012920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123012921 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123012922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123012923 DNA binding residues [nucleotide binding] 272123012924 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 272123012925 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272123012926 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272123012927 RF-1 domain; Region: RF-1; pfam00472 272123012928 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 272123012929 metal-binding heat shock protein; Provisional; Region: PRK00016 272123012930 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 272123012931 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272123012932 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272123012933 glutamine binding [chemical binding]; other site 272123012934 catalytic triad [active] 272123012935 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272123012936 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 272123012937 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 272123012938 Family description; Region: VCBS; pfam13517 272123012939 Family description; Region: VCBS; pfam13517 272123012940 Family description; Region: VCBS; pfam13517 272123012941 Family description; Region: VCBS; pfam13517 272123012942 Family description; Region: VCBS; pfam13517 272123012943 proline aminopeptidase P II; Provisional; Region: PRK10879 272123012944 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 272123012945 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 272123012946 active site 272123012947 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012948 putative active site [active] 272123012949 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272123012950 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272123012951 catalytic triad [active] 272123012952 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 272123012953 deoxyhypusine synthase; Region: dhys; TIGR00321 272123012954 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272123012955 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272123012956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123012957 dimer interface [polypeptide binding]; other site 272123012958 conserved gate region; other site 272123012959 putative PBP binding loops; other site 272123012960 ABC-ATPase subunit interface; other site 272123012961 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123012962 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123012963 structural tetrad; other site 272123012964 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 272123012965 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 272123012966 Walker A/P-loop; other site 272123012967 ATP binding site [chemical binding]; other site 272123012968 Q-loop/lid; other site 272123012969 ABC transporter signature motif; other site 272123012970 Walker B; other site 272123012971 D-loop; other site 272123012972 H-loop/switch region; other site 272123012973 TOBE domain; Region: TOBE; pfam03459 272123012974 Haemolytic domain; Region: Haemolytic; cl00506 272123012975 geranylgeranyl reductase; Region: ChlP; TIGR02028 272123012976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123012977 hypothetical protein; Provisional; Region: PRK07236 272123012978 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123012979 putative active site [active] 272123012980 PIN domain; Region: PIN_3; pfam13470 272123012981 Putative addiction module component; Region: Unstab_antitox; cl09921 272123012982 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123012983 Dynamin family; Region: Dynamin_N; pfam00350 272123012984 G1 box; other site 272123012985 GTP/Mg2+ binding site [chemical binding]; other site 272123012986 G2 box; other site 272123012987 Switch I region; other site 272123012988 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123012989 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123012990 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123012991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123012992 S-adenosylmethionine binding site [chemical binding]; other site 272123012993 ferrochelatase; Reviewed; Region: hemH; PRK00035 272123012994 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272123012995 active site 272123012996 C-terminal domain interface [polypeptide binding]; other site 272123012997 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272123012998 active site 272123012999 N-terminal domain interface [polypeptide binding]; other site 272123013000 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 272123013001 adenylosuccinate lyase; Provisional; Region: PRK07380 272123013002 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272123013003 tetramer interface [polypeptide binding]; other site 272123013004 active site 272123013005 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 272123013006 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123013007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123013008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123013009 dimer interface [polypeptide binding]; other site 272123013010 phosphorylation site [posttranslational modification] 272123013011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013012 ATP binding site [chemical binding]; other site 272123013013 Mg2+ binding site [ion binding]; other site 272123013014 G-X-G motif; other site 272123013015 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272123013016 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 272123013017 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272123013018 NAD(P) binding site [chemical binding]; other site 272123013019 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272123013020 Predicted membrane protein [Function unknown]; Region: COG1950 272123013021 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123013022 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123013023 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123013024 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123013025 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123013026 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272123013027 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272123013028 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272123013029 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272123013030 ATP-grasp domain; Region: ATP-grasp; pfam02222 272123013031 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123013032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013034 Predicted GTPase [General function prediction only]; Region: COG3596 272123013035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123013036 YfjP GTPase; Region: YfjP; cd11383 272123013037 G1 box; other site 272123013038 Walker A/P-loop; other site 272123013039 GTP/Mg2+ binding site [chemical binding]; other site 272123013040 ATP binding site [chemical binding]; other site 272123013041 Switch I region; other site 272123013042 G2 box; other site 272123013043 Switch II region; other site 272123013044 G3 box; other site 272123013045 G4 box; other site 272123013046 FOG: CBS domain [General function prediction only]; Region: COG0517 272123013047 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 272123013048 FOG: CBS domain [General function prediction only]; Region: COG0517 272123013049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 272123013050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123013051 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123013052 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123013053 PAS domain S-box; Region: sensory_box; TIGR00229 272123013054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013055 putative active site [active] 272123013056 heme pocket [chemical binding]; other site 272123013057 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123013058 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272123013059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013060 putative active site [active] 272123013061 heme pocket [chemical binding]; other site 272123013062 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123013063 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123013064 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123013065 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123013066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123013067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123013068 dimer interface [polypeptide binding]; other site 272123013069 phosphorylation site [posttranslational modification] 272123013070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013071 ATP binding site [chemical binding]; other site 272123013072 Mg2+ binding site [ion binding]; other site 272123013073 G-X-G motif; other site 272123013074 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123013075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013076 active site 272123013077 phosphorylation site [posttranslational modification] 272123013078 intermolecular recognition site; other site 272123013079 dimerization interface [polypeptide binding]; other site 272123013080 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272123013081 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272123013082 active site 272123013083 metal binding site [ion binding]; metal-binding site 272123013084 DNA binding site [nucleotide binding] 272123013085 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272123013086 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272123013087 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272123013088 Active Sites [active] 272123013089 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 272123013090 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272123013091 30S subunit binding site; other site 272123013092 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272123013093 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272123013094 catalytic triad [active] 272123013095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 272123013096 PIN domain; Region: PIN_2; cl17859 272123013097 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272123013098 GTP1/OBG; Region: GTP1_OBG; pfam01018 272123013099 Obg GTPase; Region: Obg; cd01898 272123013100 G1 box; other site 272123013101 GTP/Mg2+ binding site [chemical binding]; other site 272123013102 Switch I region; other site 272123013103 G2 box; other site 272123013104 G3 box; other site 272123013105 Switch II region; other site 272123013106 G4 box; other site 272123013107 G5 box; other site 272123013108 hypothetical protein; Reviewed; Region: PRK12275 272123013109 four helix bundle protein; Region: TIGR02436 272123013110 tellurium resistance terB-like protein; Region: terB_like; cd07177 272123013111 metal binding site [ion binding]; metal-binding site 272123013112 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 272123013113 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272123013114 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272123013115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272123013116 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272123013117 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272123013118 C-terminal domain interface [polypeptide binding]; other site 272123013119 GSH binding site (G-site) [chemical binding]; other site 272123013120 dimer interface [polypeptide binding]; other site 272123013121 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272123013122 substrate binding pocket (H-site) [chemical binding]; other site 272123013123 N-terminal domain interface [polypeptide binding]; other site 272123013124 glycogen branching enzyme; Provisional; Region: PRK05402 272123013125 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 272123013126 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272123013127 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272123013128 active site 272123013129 catalytic site [active] 272123013130 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272123013131 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013132 putative active site [active] 272123013133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123013134 NAD(P) binding site [chemical binding]; other site 272123013135 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 272123013136 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272123013137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123013138 active site 272123013139 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 272123013140 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272123013141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272123013142 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272123013143 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123013144 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 272123013145 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123013146 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123013147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123013148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123013149 DNA binding residues [nucleotide binding] 272123013150 dimerization interface [polypeptide binding]; other site 272123013151 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 272123013152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123013153 Walker A motif; other site 272123013154 ATP binding site [chemical binding]; other site 272123013155 Walker B motif; other site 272123013156 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 272123013157 RxxxH motif; other site 272123013158 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272123013159 4Fe-4S binding domain; Region: Fer4_6; pfam12837 272123013160 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 272123013161 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272123013162 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272123013163 ring oligomerisation interface [polypeptide binding]; other site 272123013164 ATP/Mg binding site [chemical binding]; other site 272123013165 stacking interactions; other site 272123013166 hinge regions; other site 272123013167 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272123013168 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272123013169 Mg++ binding site [ion binding]; other site 272123013170 putative catalytic motif [active] 272123013171 substrate binding site [chemical binding]; other site 272123013172 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272123013173 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272123013174 NAD(P) binding site [chemical binding]; other site 272123013175 homotetramer interface [polypeptide binding]; other site 272123013176 homodimer interface [polypeptide binding]; other site 272123013177 active site 272123013178 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272123013179 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272123013180 NAD(P) binding site [chemical binding]; other site 272123013181 putative active site [active] 272123013182 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272123013183 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123013184 Rubrerythrin [Energy production and conversion]; Region: COG1592 272123013185 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 272123013186 binuclear metal center [ion binding]; other site 272123013187 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272123013188 iron binding site [ion binding]; other site 272123013189 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 272123013190 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 272123013191 NADP-binding site; other site 272123013192 homotetramer interface [polypeptide binding]; other site 272123013193 substrate binding site [chemical binding]; other site 272123013194 homodimer interface [polypeptide binding]; other site 272123013195 active site 272123013196 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272123013197 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123013198 RDD family; Region: RDD; pfam06271 272123013199 HEAT repeats; Region: HEAT_2; pfam13646 272123013200 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123013201 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013202 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013203 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123013204 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013205 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272123013206 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123013207 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013208 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013209 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123013210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013211 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013212 Predicted metal-binding protein [Function unknown]; Region: COG5469 272123013213 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 272123013214 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 272123013215 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272123013216 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 272123013217 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 272123013218 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 272123013219 GxxExxY protein; Region: GxxExxY; TIGR04256 272123013220 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 272123013221 Aluminium resistance protein; Region: Alum_res; pfam06838 272123013222 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 272123013223 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272123013224 Di-iron ligands [ion binding]; other site 272123013225 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 272123013226 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 272123013227 putative di-iron ligands [ion binding]; other site 272123013228 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 272123013229 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 272123013230 putative di-iron ligands [ion binding]; other site 272123013231 Predicted ATPase [General function prediction only]; Region: COG4637 272123013232 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 272123013233 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272123013234 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272123013235 putative catalytic cysteine [active] 272123013236 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272123013237 homopentamer interface [polypeptide binding]; other site 272123013238 active site 272123013239 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 272123013240 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272123013241 DHH family; Region: DHH; pfam01368 272123013242 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123013243 FOG: CBS domain [General function prediction only]; Region: COG0517 272123013244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 272123013245 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272123013246 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272123013247 active site 272123013248 NTP binding site [chemical binding]; other site 272123013249 metal binding triad [ion binding]; metal-binding site 272123013250 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272123013251 TPR repeat; Region: TPR_11; pfam13414 272123013252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123013253 binding surface 272123013254 TPR repeat; Region: TPR_11; pfam13414 272123013255 TPR motif; other site 272123013256 TPR repeat; Region: TPR_11; pfam13414 272123013257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123013258 binding surface 272123013259 TPR motif; other site 272123013260 TPR repeat; Region: TPR_11; pfam13414 272123013261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123013262 binding surface 272123013263 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123013264 TPR motif; other site 272123013265 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272123013266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123013267 active site 272123013268 ATP binding site [chemical binding]; other site 272123013269 substrate binding site [chemical binding]; other site 272123013270 activation loop (A-loop); other site 272123013271 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123013272 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123013273 structural tetrad; other site 272123013274 2TM domain; Region: 2TM; pfam13239 272123013275 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272123013276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272123013277 nucleotide binding site [chemical binding]; other site 272123013278 arogenate dehydrogenase; Reviewed; Region: PRK07417 272123013279 prephenate dehydrogenase; Validated; Region: PRK08507 272123013280 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123013281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013282 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013284 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013285 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013286 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123013288 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 272123013289 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 272123013290 CCC1-related family of proteins; Region: CCC1_like; cd01059 272123013291 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272123013292 16S/18S rRNA binding site [nucleotide binding]; other site 272123013293 S13e-L30e interaction site [polypeptide binding]; other site 272123013294 25S rRNA binding site [nucleotide binding]; other site 272123013295 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 272123013296 UbiA prenyltransferase family; Region: UbiA; pfam01040 272123013297 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272123013298 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 272123013299 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272123013300 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272123013301 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272123013302 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272123013303 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272123013304 D-pathway; other site 272123013305 Putative ubiquinol binding site [chemical binding]; other site 272123013306 Low-spin heme (heme b) binding site [chemical binding]; other site 272123013307 Putative water exit pathway; other site 272123013308 Binuclear center (heme o3/CuB) [ion binding]; other site 272123013309 K-pathway; other site 272123013310 Putative proton exit pathway; other site 272123013311 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 272123013312 Subunit I/III interface [polypeptide binding]; other site 272123013313 PemK-like protein; Region: PemK; cl00995 272123013314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123013315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123013316 structural tetrad; other site 272123013317 Niemann-Pick C type protein family; Region: 2A060601; TIGR00917 272123013318 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 272123013319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272123013320 Zn2+ binding site [ion binding]; other site 272123013321 Mg2+ binding site [ion binding]; other site 272123013322 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 272123013323 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272123013324 Dehydroquinase class II; Region: DHquinase_II; pfam01220 272123013325 trimer interface [polypeptide binding]; other site 272123013326 active site 272123013327 dimer interface [polypeptide binding]; other site 272123013328 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272123013329 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272123013330 active site 272123013331 interdomain interaction site; other site 272123013332 putative metal-binding site [ion binding]; other site 272123013333 nucleotide binding site [chemical binding]; other site 272123013334 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 272123013335 domain I; other site 272123013336 phosphate binding site [ion binding]; other site 272123013337 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272123013338 domain II; other site 272123013339 domain III; other site 272123013340 nucleotide binding site [chemical binding]; other site 272123013341 DNA binding groove [nucleotide binding] 272123013342 catalytic site [active] 272123013343 domain IV; other site 272123013344 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272123013345 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272123013346 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272123013347 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272123013348 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013349 putative active site [active] 272123013350 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 272123013351 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272123013352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123013353 ATP binding site [chemical binding]; other site 272123013354 putative Mg++ binding site [ion binding]; other site 272123013355 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123013356 putative active site [active] 272123013357 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272123013358 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123013359 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123013360 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123013361 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123013362 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123013363 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 272123013364 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272123013365 Response regulator receiver domain; Region: Response_reg; pfam00072 272123013366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013367 active site 272123013368 phosphorylation site [posttranslational modification] 272123013369 intermolecular recognition site; other site 272123013370 dimerization interface [polypeptide binding]; other site 272123013371 lipoyl synthase; Provisional; Region: PRK12928 272123013372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123013373 FeS/SAM binding site; other site 272123013374 PsaX family; Region: PsaX; pfam08078 272123013375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272123013376 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272123013377 TM-ABC transporter signature motif; other site 272123013378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123013379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123013380 dimer interface [polypeptide binding]; other site 272123013381 phosphorylation site [posttranslational modification] 272123013382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013383 ATP binding site [chemical binding]; other site 272123013384 Mg2+ binding site [ion binding]; other site 272123013385 G-X-G motif; other site 272123013386 Response regulator receiver domain; Region: Response_reg; pfam00072 272123013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013388 active site 272123013389 phosphorylation site [posttranslational modification] 272123013390 intermolecular recognition site; other site 272123013391 dimerization interface [polypeptide binding]; other site 272123013392 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013393 putative active site [active] 272123013394 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 272123013395 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 272123013396 Ligand Binding Site [chemical binding]; other site 272123013397 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 272123013398 active site 272123013399 catalytic triad [active] 272123013400 oxyanion hole [active] 272123013401 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 272123013402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123013403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013404 ATP binding site [chemical binding]; other site 272123013405 Mg2+ binding site [ion binding]; other site 272123013406 G-X-G motif; other site 272123013407 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 272123013408 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272123013409 DNA protecting protein DprA; Region: dprA; TIGR00732 272123013410 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 272123013411 nudix motif; other site 272123013412 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272123013413 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272123013414 HIGH motif; other site 272123013415 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272123013416 active site 272123013417 KMSKS motif; other site 272123013418 cell division protein; Validated; Region: ftsH; CHL00176 272123013419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123013420 Walker A motif; other site 272123013421 ATP binding site [chemical binding]; other site 272123013422 Walker B motif; other site 272123013423 arginine finger; other site 272123013424 Peptidase family M41; Region: Peptidase_M41; pfam01434 272123013425 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 272123013426 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 272123013427 active site 272123013428 Na/Ca binding site [ion binding]; other site 272123013429 catalytic site [active] 272123013430 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272123013431 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272123013432 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272123013433 [2Fe-2S] cluster binding site [ion binding]; other site 272123013434 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272123013435 hydrophobic ligand binding site; other site 272123013436 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272123013437 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272123013438 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272123013439 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272123013440 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272123013441 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272123013442 Catalytic site [active] 272123013443 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 272123013444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123013445 ATP binding site [chemical binding]; other site 272123013446 putative Mg++ binding site [ion binding]; other site 272123013447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123013448 nucleotide binding region [chemical binding]; other site 272123013449 ATP-binding site [chemical binding]; other site 272123013450 GxxExxY protein; Region: GxxExxY; TIGR04256 272123013451 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 272123013452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123013453 Walker A/P-loop; other site 272123013454 ATP binding site [chemical binding]; other site 272123013455 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013456 putative active site [active] 272123013457 S-layer homology domain; Region: SLH; pfam00395 272123013458 S-layer homology domain; Region: SLH; pfam00395 272123013459 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 272123013460 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013461 putative active site [active] 272123013462 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 272123013463 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 272123013464 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272123013465 DGQHR domain; Region: DGQHR; TIGR03187 272123013466 DNA-sulfur modification-associated; Region: DndB; cl17621 272123013467 hypothetical protein; Provisional; Region: PRK06850 272123013468 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272123013469 Active Sites [active] 272123013470 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 272123013471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123013472 Walker A/P-loop; other site 272123013473 ATP binding site [chemical binding]; other site 272123013474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123013475 ABC transporter signature motif; other site 272123013476 Walker B; other site 272123013477 D-loop; other site 272123013478 H-loop/switch region; other site 272123013479 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 272123013480 muropeptide transporter; Validated; Region: ampG; cl17669 272123013481 muropeptide transporter; Reviewed; Region: ampG; PRK11902 272123013482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123013483 Coenzyme A binding pocket [chemical binding]; other site 272123013484 HEAT repeats; Region: HEAT_2; pfam13646 272123013485 HEAT repeats; Region: HEAT_2; pfam13646 272123013486 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 272123013487 protein binding surface [polypeptide binding]; other site 272123013488 HEAT repeats; Region: HEAT_2; pfam13646 272123013489 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272123013490 ligand binding site [chemical binding]; other site 272123013491 active site 272123013492 UGI interface [polypeptide binding]; other site 272123013493 catalytic site [active] 272123013494 Cupin domain; Region: Cupin_2; cl17218 272123013495 Response regulator receiver domain; Region: Response_reg; pfam00072 272123013496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013497 active site 272123013498 phosphorylation site [posttranslational modification] 272123013499 intermolecular recognition site; other site 272123013500 dimerization interface [polypeptide binding]; other site 272123013501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123013502 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272123013503 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123013504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013505 putative active site [active] 272123013506 heme pocket [chemical binding]; other site 272123013507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013508 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123013509 putative active site [active] 272123013510 heme pocket [chemical binding]; other site 272123013511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013512 putative active site [active] 272123013513 heme pocket [chemical binding]; other site 272123013514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123013515 GAF domain; Region: GAF; pfam01590 272123013516 PAS domain S-box; Region: sensory_box; TIGR00229 272123013517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013518 putative active site [active] 272123013519 heme pocket [chemical binding]; other site 272123013520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013521 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123013522 putative active site [active] 272123013523 heme pocket [chemical binding]; other site 272123013524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013525 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272123013526 putative active site [active] 272123013527 heme pocket [chemical binding]; other site 272123013528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013529 putative active site [active] 272123013530 heme pocket [chemical binding]; other site 272123013531 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123013532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013533 putative active site [active] 272123013534 heme pocket [chemical binding]; other site 272123013535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123013536 dimer interface [polypeptide binding]; other site 272123013537 phosphorylation site [posttranslational modification] 272123013538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013539 ATP binding site [chemical binding]; other site 272123013540 Mg2+ binding site [ion binding]; other site 272123013541 G-X-G motif; other site 272123013542 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272123013543 conserved cys residue [active] 272123013544 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272123013545 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 272123013546 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 272123013547 Protein of unknown function (DUF512); Region: DUF512; pfam04459 272123013548 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272123013549 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 272123013550 Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514 272123013551 L-aspartate oxidase; Provisional; Region: PRK07395 272123013552 L-aspartate oxidase; Provisional; Region: PRK06175 272123013553 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 272123013554 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272123013555 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123013556 CHASE2 domain; Region: CHASE2; pfam05226 272123013557 PAS domain S-box; Region: sensory_box; TIGR00229 272123013558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013559 putative active site [active] 272123013560 heme pocket [chemical binding]; other site 272123013561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123013562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123013563 metal binding site [ion binding]; metal-binding site 272123013564 active site 272123013565 I-site; other site 272123013566 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 272123013567 substrate binding site [chemical binding]; other site 272123013568 putative active site [active] 272123013569 redox center [active] 272123013570 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272123013571 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 272123013572 phosphate binding site [ion binding]; other site 272123013573 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 272123013574 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272123013575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123013576 FeS/SAM binding site; other site 272123013577 TRAM domain; Region: TRAM; cl01282 272123013578 helicase 45; Provisional; Region: PTZ00424 272123013579 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272123013580 ATP binding site [chemical binding]; other site 272123013581 Mg++ binding site [ion binding]; other site 272123013582 motif III; other site 272123013583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123013584 nucleotide binding region [chemical binding]; other site 272123013585 ATP-binding site [chemical binding]; other site 272123013586 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123013587 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123013588 active site 272123013589 catalytic tetrad [active] 272123013590 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123013591 cyclase homology domain; Region: CHD; cd07302 272123013592 nucleotidyl binding site; other site 272123013593 metal binding site [ion binding]; metal-binding site 272123013594 dimer interface [polypeptide binding]; other site 272123013595 PUCC protein; Region: PUCC; pfam03209 272123013596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123013597 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 272123013598 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272123013599 dimer interface [polypeptide binding]; other site 272123013600 ADP-ribose binding site [chemical binding]; other site 272123013601 active site 272123013602 nudix motif; other site 272123013603 metal binding site [ion binding]; metal-binding site 272123013604 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272123013605 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 272123013606 active site 272123013607 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 272123013608 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272123013609 putative NAD(P) binding site [chemical binding]; other site 272123013610 catalytic Zn binding site [ion binding]; other site 272123013611 structural Zn binding site [ion binding]; other site 272123013612 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 272123013613 heme-binding site [chemical binding]; other site 272123013614 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 272123013615 UbiA prenyltransferase family; Region: UbiA; pfam01040 272123013616 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 272123013617 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272123013618 P loop; other site 272123013619 Nucleotide binding site [chemical binding]; other site 272123013620 DTAP/Switch II; other site 272123013621 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 272123013622 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123013623 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123013624 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013625 putative active site [active] 272123013626 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272123013627 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123013628 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272123013629 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272123013630 Walker A/P-loop; other site 272123013631 ATP binding site [chemical binding]; other site 272123013632 Q-loop/lid; other site 272123013633 ABC transporter signature motif; other site 272123013634 Walker B; other site 272123013635 D-loop; other site 272123013636 H-loop/switch region; other site 272123013637 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123013638 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272123013639 active site 272123013640 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272123013641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123013642 UDP-galactopyranose mutase; Region: GLF; pfam03275 272123013643 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272123013644 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123013645 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272123013646 Probable Catalytic site; other site 272123013647 metal-binding site 272123013648 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272123013649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123013650 active site 272123013651 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272123013652 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123013653 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272123013654 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272123013655 Walker A/P-loop; other site 272123013656 ATP binding site [chemical binding]; other site 272123013657 Q-loop/lid; other site 272123013658 ABC transporter signature motif; other site 272123013659 Walker B; other site 272123013660 D-loop; other site 272123013661 H-loop/switch region; other site 272123013662 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123013663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123013664 S-adenosylmethionine binding site [chemical binding]; other site 272123013665 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272123013666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123013667 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272123013668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123013669 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272123013670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123013671 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272123013672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272123013673 pyruvate kinase; Provisional; Region: PRK06354 272123013674 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272123013675 domain interfaces; other site 272123013676 active site 272123013677 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 272123013678 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 272123013679 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272123013680 putative di-iron ligands [ion binding]; other site 272123013681 Divergent AAA domain; Region: AAA_4; pfam04326 272123013682 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 272123013683 homotrimer interaction site [polypeptide binding]; other site 272123013684 active site 272123013685 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272123013686 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 272123013687 tandem repeat interface [polypeptide binding]; other site 272123013688 oligomer interface [polypeptide binding]; other site 272123013689 active site residues [active] 272123013690 BCCT family transporter; Region: BCCT; cl00569 272123013691 Permease; Region: Permease; cl00510 272123013692 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272123013693 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 272123013694 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272123013695 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 272123013696 membrane protein; Provisional; Region: PRK14419 272123013697 GTP-binding protein Der; Reviewed; Region: PRK00093 272123013698 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272123013699 G1 box; other site 272123013700 GTP/Mg2+ binding site [chemical binding]; other site 272123013701 Switch I region; other site 272123013702 G2 box; other site 272123013703 Switch II region; other site 272123013704 G3 box; other site 272123013705 G4 box; other site 272123013706 G5 box; other site 272123013707 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272123013708 G1 box; other site 272123013709 GTP/Mg2+ binding site [chemical binding]; other site 272123013710 Switch I region; other site 272123013711 G2 box; other site 272123013712 G3 box; other site 272123013713 Switch II region; other site 272123013714 G4 box; other site 272123013715 G5 box; other site 272123013716 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272123013717 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123013718 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123013719 dimer interface [polypeptide binding]; other site 272123013720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123013721 catalytic residue [active] 272123013722 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272123013723 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 272123013724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123013725 S-adenosylmethionine binding site [chemical binding]; other site 272123013726 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 272123013727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123013728 active site 272123013729 motif I; other site 272123013730 motif II; other site 272123013731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272123013732 Helix-turn-helix domain; Region: HTH_17; pfam12728 272123013733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123013734 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272123013735 DNA methylase; Region: N6_N4_Mtase; pfam01555 272123013736 Restriction endonuclease BamHI; Region: BamHI; pfam02923 272123013737 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 272123013738 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 272123013739 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123013740 metal ion-dependent adhesion site (MIDAS); other site 272123013741 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272123013742 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272123013743 FMN binding site [chemical binding]; other site 272123013744 active site 272123013745 catalytic residues [active] 272123013746 substrate binding site [chemical binding]; other site 272123013747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123013748 PAS fold; Region: PAS_3; pfam08447 272123013749 putative active site [active] 272123013750 heme pocket [chemical binding]; other site 272123013751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123013752 dimer interface [polypeptide binding]; other site 272123013753 phosphorylation site [posttranslational modification] 272123013754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123013755 ATP binding site [chemical binding]; other site 272123013756 Mg2+ binding site [ion binding]; other site 272123013757 G-X-G motif; other site 272123013758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013759 active site 272123013760 phosphorylation site [posttranslational modification] 272123013761 intermolecular recognition site; other site 272123013762 Response regulator receiver domain; Region: Response_reg; pfam00072 272123013763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013764 active site 272123013765 phosphorylation site [posttranslational modification] 272123013766 intermolecular recognition site; other site 272123013767 dimerization interface [polypeptide binding]; other site 272123013768 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272123013769 putative binding surface; other site 272123013770 active site 272123013771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123013772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013773 active site 272123013774 phosphorylation site [posttranslational modification] 272123013775 intermolecular recognition site; other site 272123013776 dimerization interface [polypeptide binding]; other site 272123013777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123013778 DNA binding site [nucleotide binding] 272123013779 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272123013780 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272123013781 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272123013782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272123013783 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272123013784 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272123013785 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 272123013786 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 272123013787 Probable Catalytic site; other site 272123013788 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 272123013789 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 272123013790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123013791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123013792 homodimer interface [polypeptide binding]; other site 272123013793 catalytic residue [active] 272123013794 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 272123013795 RloB-like protein; Region: RloB; pfam13707 272123013796 Predicted ATPases [General function prediction only]; Region: COG1106 272123013797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123013798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123013799 active site 272123013800 ATP binding site [chemical binding]; other site 272123013801 substrate binding site [chemical binding]; other site 272123013802 activation loop (A-loop); other site 272123013803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123013804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123013805 active site 272123013806 ATP binding site [chemical binding]; other site 272123013807 substrate binding site [chemical binding]; other site 272123013808 activation loop (A-loop); other site 272123013809 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123013810 G1 box; other site 272123013811 GTP/Mg2+ binding site [chemical binding]; other site 272123013812 G2 box; other site 272123013813 Switch I region; other site 272123013814 G3 box; other site 272123013815 Switch II region; other site 272123013816 G4 box; other site 272123013817 G5 box; other site 272123013818 PIN domain; Region: PIN; pfam01850 272123013819 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 272123013820 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123013821 oligomeric interface; other site 272123013822 putative active site [active] 272123013823 homodimer interface [polypeptide binding]; other site 272123013824 Protein of unknown function (DUF433); Region: DUF433; cl01030 272123013825 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 272123013826 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123013827 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123013828 structural tetrad; other site 272123013829 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 272123013830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272123013831 acyl-activating enzyme (AAE) consensus motif; other site 272123013832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 272123013833 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 272123013834 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 272123013835 putative active site [active] 272123013836 catalytic site [active] 272123013837 putative metal binding site [ion binding]; other site 272123013838 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 272123013839 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 272123013840 putative active site [active] 272123013841 catalytic site [active] 272123013842 putative metal binding site [ion binding]; other site 272123013843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 272123013844 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272123013845 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 272123013846 putative active site [active] 272123013847 putative metal binding site [ion binding]; other site 272123013848 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272123013849 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 272123013850 Phytase; Region: Phytase; cl17685 272123013851 PhoD-like phosphatase; Region: PhoD; pfam09423 272123013852 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 272123013853 putative active site [active] 272123013854 Phytase; Region: Phytase; cl17685 272123013855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 272123013856 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 272123013857 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 272123013858 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 272123013859 active site 272123013860 dimer interface [polypeptide binding]; other site 272123013861 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272123013862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272123013863 ABC-ATPase subunit interface; other site 272123013864 dimer interface [polypeptide binding]; other site 272123013865 putative PBP binding regions; other site 272123013866 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272123013867 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272123013868 Walker A/P-loop; other site 272123013869 ATP binding site [chemical binding]; other site 272123013870 Q-loop/lid; other site 272123013871 ABC transporter signature motif; other site 272123013872 Walker B; other site 272123013873 D-loop; other site 272123013874 H-loop/switch region; other site 272123013875 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272123013876 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272123013877 NodB motif; other site 272123013878 active site 272123013879 catalytic site [active] 272123013880 metal binding site [ion binding]; metal-binding site 272123013881 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123013882 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123013883 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 272123013884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 272123013885 bifunctional UGMP family protein/serine/threonine protein kinase; Validated; Region: PRK09605 272123013886 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123013887 structural tetrad; other site 272123013888 PQQ-like domain; Region: PQQ_2; pfam13360 272123013889 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 272123013890 putative acyl transferase; Provisional; Region: PRK10502 272123013891 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 272123013892 putative trimer interface [polypeptide binding]; other site 272123013893 putative active site [active] 272123013894 putative substrate binding site [chemical binding]; other site 272123013895 putative CoA binding site [chemical binding]; other site 272123013896 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272123013897 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272123013898 putative metal binding site; other site 272123013899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123013900 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123013901 active site 272123013902 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272123013903 homotrimer interface [polypeptide binding]; other site 272123013904 Walker A motif; other site 272123013905 GTP binding site [chemical binding]; other site 272123013906 Walker B motif; other site 272123013907 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272123013908 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 272123013909 putative active site [active] 272123013910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123013911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123013912 Walker A/P-loop; other site 272123013913 ATP binding site [chemical binding]; other site 272123013914 Q-loop/lid; other site 272123013915 ABC transporter signature motif; other site 272123013916 Walker B; other site 272123013917 D-loop; other site 272123013918 H-loop/switch region; other site 272123013919 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272123013920 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123013921 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123013922 BRE1 E3 ubiquitin ligase; Region: BRE1; pfam08647 272123013923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123013924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123013925 active site 272123013926 phosphorylation site [posttranslational modification] 272123013927 intermolecular recognition site; other site 272123013928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272123013929 ribonuclease Z; Region: RNase_Z; TIGR02651 272123013930 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272123013931 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272123013932 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 272123013933 Stage II sporulation protein; Region: SpoIID; pfam08486 272123013934 hydrolase, alpha/beta fold family protein; Region: PLN02824 272123013935 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 272123013936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272123013937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272123013938 active site 272123013939 catalytic tetrad [active] 272123013940 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 272123013941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123013942 non-specific DNA binding site [nucleotide binding]; other site 272123013943 salt bridge; other site 272123013944 sequence-specific DNA binding site [nucleotide binding]; other site 272123013945 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 272123013946 ligand binding site [chemical binding]; other site 272123013947 active site 272123013948 Clp protease ATP binding subunit; Region: clpC; CHL00095 272123013949 Clp amino terminal domain; Region: Clp_N; pfam02861 272123013950 Clp amino terminal domain; Region: Clp_N; pfam02861 272123013951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123013952 Walker A motif; other site 272123013953 ATP binding site [chemical binding]; other site 272123013954 Walker B motif; other site 272123013955 arginine finger; other site 272123013956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123013957 Walker A motif; other site 272123013958 ATP binding site [chemical binding]; other site 272123013959 Walker B motif; other site 272123013960 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272123013961 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 272123013962 mce related protein; Region: MCE; pfam02470 272123013963 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272123013964 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272123013965 Walker A/P-loop; other site 272123013966 ATP binding site [chemical binding]; other site 272123013967 Q-loop/lid; other site 272123013968 ABC transporter signature motif; other site 272123013969 Walker B; other site 272123013970 D-loop; other site 272123013971 H-loop/switch region; other site 272123013972 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272123013973 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272123013974 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272123013975 shikimate binding site; other site 272123013976 NAD(P) binding site [chemical binding]; other site 272123013977 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272123013978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123013979 motif II; other site 272123013980 30S ribosomal protein S1; Reviewed; Region: PRK07400 272123013981 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272123013982 RNA binding site [nucleotide binding]; other site 272123013983 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272123013984 RNA binding site [nucleotide binding]; other site 272123013985 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272123013986 RNA binding site [nucleotide binding]; other site 272123013987 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 272123013988 photosystem II 47 kDa protein; Region: psbB; CHL00062 272123013989 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 272123013990 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 272123013991 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123013992 putative active site [active] 272123013993 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272123013994 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 272123013995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272123013996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123013997 dimer interface [polypeptide binding]; other site 272123013998 conserved gate region; other site 272123013999 putative PBP binding loops; other site 272123014000 ABC-ATPase subunit interface; other site 272123014001 TIGR04255 family protein; Region: sporadTIGR04255 272123014002 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272123014003 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272123014004 nucleotide binding site [chemical binding]; other site 272123014005 NEF interaction site [polypeptide binding]; other site 272123014006 SBD interface [polypeptide binding]; other site 272123014007 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123014008 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 272123014009 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 272123014010 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 272123014011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123014012 putative metal binding site [ion binding]; other site 272123014013 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272123014014 arsenical-resistance protein; Region: acr3; TIGR00832 272123014015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123014016 putative substrate translocation pore; other site 272123014017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272123014018 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 272123014019 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272123014020 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272123014021 PBP superfamily domain; Region: PBP_like_2; cl17296 272123014022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123014023 dimerization interface [polypeptide binding]; other site 272123014024 putative DNA binding site [nucleotide binding]; other site 272123014025 putative Zn2+ binding site [ion binding]; other site 272123014026 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123014027 aspartate aminotransferase; Provisional; Region: PRK05942 272123014028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123014029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123014030 homodimer interface [polypeptide binding]; other site 272123014031 catalytic residue [active] 272123014032 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272123014033 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272123014034 putative active site [active] 272123014035 metal binding site [ion binding]; metal-binding site 272123014036 Protein of function (DUF2518); Region: DUF2518; pfam10726 272123014037 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 272123014038 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 272123014039 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 272123014040 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123014041 putative active site [active] 272123014042 tyramine oxidase; Provisional; Region: tynA; PRK11504 272123014043 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 272123014044 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 272123014045 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 272123014046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014047 binding surface 272123014048 TPR motif; other site 272123014049 TPR repeat; Region: TPR_11; pfam13414 272123014050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272123014051 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272123014052 substrate binding pocket [chemical binding]; other site 272123014053 membrane-bound complex binding site; other site 272123014054 hinge residues; other site 272123014055 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272123014056 23S rRNA binding site [nucleotide binding]; other site 272123014057 L21 binding site [polypeptide binding]; other site 272123014058 L13 binding site [polypeptide binding]; other site 272123014059 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272123014060 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272123014061 Family description; Region: UvrD_C_2; pfam13538 272123014062 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272123014063 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014065 active site 272123014066 phosphorylation site [posttranslational modification] 272123014067 intermolecular recognition site; other site 272123014068 dimerization interface [polypeptide binding]; other site 272123014069 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014070 GAF domain; Region: GAF; pfam01590 272123014071 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272123014072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014073 S-adenosylmethionine binding site [chemical binding]; other site 272123014074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 272123014075 light-harvesting-like protein 3; Provisional; Region: PLN00014 272123014076 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272123014077 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272123014078 hexamer interface [polypeptide binding]; other site 272123014079 ligand binding site [chemical binding]; other site 272123014080 putative active site [active] 272123014081 NAD(P) binding site [chemical binding]; other site 272123014082 NB-ARC domain; Region: NB-ARC; pfam00931 272123014083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272123014084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272123014085 putative active site [active] 272123014086 putative metal binding site [ion binding]; other site 272123014087 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272123014088 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272123014089 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272123014090 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272123014091 Tetramer interface [polypeptide binding]; other site 272123014092 active site 272123014093 FMN-binding site [chemical binding]; other site 272123014094 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 272123014095 putative active site [active] 272123014096 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272123014097 DHH family; Region: DHH; pfam01368 272123014098 hypothetical protein; Provisional; Region: PRK13686 272123014099 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 272123014100 Predicted membrane protein [Function unknown]; Region: COG2119 272123014101 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272123014102 Predicted membrane protein [Function unknown]; Region: COG2119 272123014103 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272123014104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123014105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014106 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014107 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123014108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123014109 PAS domain; Region: PAS_9; pfam13426 272123014110 putative active site [active] 272123014111 heme pocket [chemical binding]; other site 272123014112 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123014113 cyclase homology domain; Region: CHD; cd07302 272123014114 nucleotidyl binding site; other site 272123014115 metal binding site [ion binding]; metal-binding site 272123014116 dimer interface [polypeptide binding]; other site 272123014117 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272123014118 Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573 272123014119 Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; Region: CHROMO; cd00024 272123014120 histone binding site; other site 272123014121 XisI protein; Region: XisI; pfam08869 272123014122 XisH protein; Region: XisH; pfam08814 272123014123 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272123014124 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272123014125 homotetramer interface [polypeptide binding]; other site 272123014126 ligand binding site [chemical binding]; other site 272123014127 catalytic site [active] 272123014128 NAD binding site [chemical binding]; other site 272123014129 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272123014130 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272123014131 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 272123014132 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 272123014133 substrate binding site [chemical binding]; other site 272123014134 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 272123014135 substrate binding site [chemical binding]; other site 272123014136 ligand binding site [chemical binding]; other site 272123014137 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272123014138 LabA_like proteins; Region: LabA_like/DUF88; cl10034 272123014139 putative metal binding site [ion binding]; other site 272123014140 OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872 272123014141 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272123014142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014143 S-adenosylmethionine binding site [chemical binding]; other site 272123014144 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272123014145 TrkA-N domain; Region: TrkA_N; pfam02254 272123014146 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 272123014147 TrkA-N domain; Region: TrkA_N; pfam02254 272123014148 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123014149 CHASE2 domain; Region: CHASE2; pfam05226 272123014150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123014151 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123014152 active site 272123014153 ATP binding site [chemical binding]; other site 272123014154 substrate binding site [chemical binding]; other site 272123014155 activation loop (A-loop); other site 272123014156 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272123014157 LabA_like proteins; Region: LabA; cd10911 272123014158 putative metal binding site [ion binding]; other site 272123014159 2-isopropylmalate synthase; Validated; Region: PRK00915 272123014160 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272123014161 active site 272123014162 catalytic residues [active] 272123014163 metal binding site [ion binding]; metal-binding site 272123014164 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 272123014165 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123014166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123014167 AAA domain; Region: AAA_21; pfam13304 272123014168 Walker A/P-loop; other site 272123014169 ATP binding site [chemical binding]; other site 272123014170 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123014171 active site 272123014172 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272123014173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123014174 ATP binding site [chemical binding]; other site 272123014175 putative Mg++ binding site [ion binding]; other site 272123014176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123014177 nucleotide binding region [chemical binding]; other site 272123014178 ATP-binding site [chemical binding]; other site 272123014179 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272123014180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272123014181 PIN domain; Region: PIN_3; pfam13470 272123014182 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272123014183 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272123014184 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272123014185 dimer interface [polypeptide binding]; other site 272123014186 motif 1; other site 272123014187 active site 272123014188 motif 2; other site 272123014189 motif 3; other site 272123014190 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 272123014191 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272123014192 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272123014193 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272123014194 active site 272123014195 Riboflavin kinase; Region: Flavokinase; pfam01687 272123014196 MoxR-like ATPases [General function prediction only]; Region: COG0714 272123014197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123014198 Walker A motif; other site 272123014199 ATP binding site [chemical binding]; other site 272123014200 Walker B motif; other site 272123014201 arginine finger; other site 272123014202 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 272123014203 Divergent AAA domain; Region: AAA_4; pfam04326 272123014204 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 272123014205 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 272123014206 RNA recognition motif; Region: RRM; smart00360 272123014207 cytochrome c-550; Provisional; Region: psbV; cl17239 272123014208 Dihaem cytochrome c; Region: DHC; pfam09626 272123014209 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 272123014210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123014211 ATP binding site [chemical binding]; other site 272123014212 putative Mg++ binding site [ion binding]; other site 272123014213 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272123014214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014215 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123014216 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272123014217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123014218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123014219 AAA domain; Region: AAA_21; pfam13304 272123014220 Walker A/P-loop; other site 272123014221 Walker A/P-loop; other site 272123014222 ATP binding site [chemical binding]; other site 272123014223 ATP binding site [chemical binding]; other site 272123014224 Q-loop/lid; other site 272123014225 AAA domain; Region: AAA_21; pfam13304 272123014226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123014227 non-specific DNA binding site [nucleotide binding]; other site 272123014228 salt bridge; other site 272123014229 sequence-specific DNA binding site [nucleotide binding]; other site 272123014230 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 272123014231 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 272123014232 active site 272123014233 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014235 active site 272123014236 phosphorylation site [posttranslational modification] 272123014237 intermolecular recognition site; other site 272123014238 dimerization interface [polypeptide binding]; other site 272123014239 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014241 active site 272123014242 phosphorylation site [posttranslational modification] 272123014243 intermolecular recognition site; other site 272123014244 dimerization interface [polypeptide binding]; other site 272123014245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123014246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123014247 dimer interface [polypeptide binding]; other site 272123014248 phosphorylation site [posttranslational modification] 272123014249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123014250 ATP binding site [chemical binding]; other site 272123014251 Mg2+ binding site [ion binding]; other site 272123014252 G-X-G motif; other site 272123014253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123014254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014255 active site 272123014256 phosphorylation site [posttranslational modification] 272123014257 intermolecular recognition site; other site 272123014258 dimerization interface [polypeptide binding]; other site 272123014259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123014260 DNA binding site [nucleotide binding] 272123014261 Hpt domain; Region: Hpt; pfam01627 272123014262 putative binding surface; other site 272123014263 active site 272123014264 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123014265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014266 active site 272123014267 phosphorylation site [posttranslational modification] 272123014268 intermolecular recognition site; other site 272123014269 dimerization interface [polypeptide binding]; other site 272123014270 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014272 active site 272123014273 phosphorylation site [posttranslational modification] 272123014274 intermolecular recognition site; other site 272123014275 dimerization interface [polypeptide binding]; other site 272123014276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123014277 dimer interface [polypeptide binding]; other site 272123014278 phosphorylation site [posttranslational modification] 272123014279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123014280 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014282 active site 272123014283 phosphorylation site [posttranslational modification] 272123014284 intermolecular recognition site; other site 272123014285 dimerization interface [polypeptide binding]; other site 272123014286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014287 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123014288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123014289 PAS fold; Region: PAS_3; pfam08447 272123014290 putative active site [active] 272123014291 heme pocket [chemical binding]; other site 272123014292 PAS fold; Region: PAS_4; pfam08448 272123014293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123014294 putative active site [active] 272123014295 heme pocket [chemical binding]; other site 272123014296 GAF domain; Region: GAF; pfam01590 272123014297 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014298 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123014299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123014300 dimer interface [polypeptide binding]; other site 272123014301 phosphorylation site [posttranslational modification] 272123014302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123014303 ATP binding site [chemical binding]; other site 272123014304 Mg2+ binding site [ion binding]; other site 272123014305 G-X-G motif; other site 272123014306 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123014307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014308 active site 272123014309 phosphorylation site [posttranslational modification] 272123014310 intermolecular recognition site; other site 272123014311 dimerization interface [polypeptide binding]; other site 272123014312 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272123014313 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272123014314 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272123014315 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272123014316 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 272123014317 precorrin-3B synthase; Region: CobG; TIGR02435 272123014318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123014319 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123014320 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272123014321 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 272123014322 Precorrin-8X methylmutase; Region: CbiC; pfam02570 272123014323 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272123014324 active site 272123014325 SAM binding site [chemical binding]; other site 272123014326 homodimer interface [polypeptide binding]; other site 272123014327 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 272123014328 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 272123014329 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 272123014330 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272123014331 active site 272123014332 SAM binding site [chemical binding]; other site 272123014333 homodimer interface [polypeptide binding]; other site 272123014334 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 272123014335 nucleotide binding site/active site [active] 272123014336 HIT family signature motif; other site 272123014337 catalytic residue [active] 272123014338 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 272123014339 protein I interface; other site 272123014340 D2 interface; other site 272123014341 protein T interface; other site 272123014342 chlorophyll binding site; other site 272123014343 beta carotene binding site; other site 272123014344 pheophytin binding site; other site 272123014345 manganese-stabilizing polypeptide interface; other site 272123014346 CP43 interface; other site 272123014347 protein L interface; other site 272123014348 oxygen evolving complex binding site; other site 272123014349 bromide binding site; other site 272123014350 quinone binding site; other site 272123014351 Fe binding site [ion binding]; other site 272123014352 core light harvesting interface; other site 272123014353 cytochrome b559 alpha subunit interface; other site 272123014354 cytochrome c-550 interface; other site 272123014355 protein J interface; other site 272123014356 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 272123014357 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272123014358 putative ADP-binding pocket [chemical binding]; other site 272123014359 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 272123014360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272123014361 motif II; other site 272123014362 recombination protein RecR; Reviewed; Region: recR; PRK00076 272123014363 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 272123014364 RecR protein; Region: RecR; pfam02132 272123014365 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272123014366 putative active site [active] 272123014367 putative metal-binding site [ion binding]; other site 272123014368 tetramer interface [polypeptide binding]; other site 272123014369 O-Antigen ligase; Region: Wzy_C; cl04850 272123014370 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272123014371 O-Antigen ligase; Region: Wzy_C; pfam04932 272123014372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 272123014373 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123014374 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272123014375 S-adenosylmethionine binding site [chemical binding]; other site 272123014376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272123014377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272123014378 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272123014379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272123014380 active site 272123014381 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123014382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014383 Core-2/I-Branching enzyme; Region: Branch; pfam02485 272123014384 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272123014385 dimer interface [polypeptide binding]; other site 272123014386 catalytic triad [active] 272123014387 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272123014388 HEAT repeats; Region: HEAT_2; pfam13646 272123014389 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272123014390 EamA-like transporter family; Region: EamA; pfam00892 272123014391 EamA-like transporter family; Region: EamA; pfam00892 272123014392 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272123014393 DNA methylase; Region: N6_N4_Mtase; pfam01555 272123014394 Calx-beta domain; Region: Calx-beta; pfam03160 272123014395 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123014396 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 272123014397 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272123014398 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272123014399 putative active site [active] 272123014400 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 272123014401 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272123014402 active site 272123014403 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272123014404 catalytic residues [active] 272123014405 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272123014406 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 272123014407 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 272123014408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 272123014409 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 272123014410 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 272123014411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 272123014412 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272123014413 LabA_like proteins; Region: LabA; cd10911 272123014414 putative metal binding site [ion binding]; other site 272123014415 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272123014416 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272123014417 active site 272123014418 HIGH motif; other site 272123014419 KMSKS motif; other site 272123014420 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272123014421 anticodon binding site; other site 272123014422 tRNA binding surface [nucleotide binding]; other site 272123014423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272123014424 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272123014425 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272123014426 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272123014427 interface (dimer of trimers) [polypeptide binding]; other site 272123014428 Substrate-binding/catalytic site; other site 272123014429 Zn-binding sites [ion binding]; other site 272123014430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123014431 non-specific DNA binding site [nucleotide binding]; other site 272123014432 salt bridge; other site 272123014433 sequence-specific DNA binding site [nucleotide binding]; other site 272123014434 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 272123014435 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123014436 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123014437 putative phosphate acyltransferase; Provisional; Region: PRK05331 272123014438 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272123014439 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272123014440 dimer interface [polypeptide binding]; other site 272123014441 active site 272123014442 CoA binding pocket [chemical binding]; other site 272123014443 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272123014444 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123014445 Protein of unknown function (DUF433); Region: DUF433; cl01030 272123014446 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 272123014447 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 272123014448 putative di-iron ligands [ion binding]; other site 272123014449 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 272123014450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272123014451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272123014452 putative acyl-acceptor binding pocket; other site 272123014453 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272123014454 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272123014455 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 272123014456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272123014457 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 272123014458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123014459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123014460 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123014461 oligomeric interface; other site 272123014462 putative active site [active] 272123014463 homodimer interface [polypeptide binding]; other site 272123014464 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 272123014465 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272123014466 RNA binding site [nucleotide binding]; other site 272123014467 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272123014468 RNA binding site [nucleotide binding]; other site 272123014469 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 272123014470 RNA binding site [nucleotide binding]; other site 272123014471 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272123014472 Predicted transcriptional regulators [Transcription]; Region: COG1725 272123014473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272123014474 DNA-binding site [nucleotide binding]; DNA binding site 272123014475 ribosomal protein L32; Validated; Region: rpl32; CHL00152 272123014476 Caspase domain; Region: Peptidase_C14; pfam00656 272123014477 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 272123014478 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272123014479 DXD motif; other site 272123014480 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 272123014481 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 272123014482 Active site cavity [active] 272123014483 catalytic acid [active] 272123014484 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272123014485 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272123014486 dimer interface [polypeptide binding]; other site 272123014487 active site 272123014488 aspartate-rich active site metal binding site; other site 272123014489 allosteric magnesium binding site [ion binding]; other site 272123014490 Schiff base residues; other site 272123014491 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 272123014492 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272123014493 Pleckstrin homology-like domain; Region: PH-like; cl17171 272123014494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123014495 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272123014496 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272123014497 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272123014498 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 272123014499 homodecamer interface [polypeptide binding]; other site 272123014500 GTP cyclohydrolase I; Provisional; Region: PLN03044 272123014501 active site 272123014502 putative catalytic site residues [active] 272123014503 zinc binding site [ion binding]; other site 272123014504 GTP-CH-I/GFRP interaction surface; other site 272123014505 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 272123014506 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 272123014507 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272123014508 active site 272123014509 metal binding site [ion binding]; metal-binding site 272123014510 hypothetical protein; Reviewed; Region: PRK00024 272123014511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272123014512 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272123014513 MPN+ (JAMM) motif; other site 272123014514 Zinc-binding site [ion binding]; other site 272123014515 Exoribonuclease R [Transcription]; Region: VacB; COG0557 272123014516 RNB domain; Region: RNB; pfam00773 272123014517 ribosomal protein S18; Region: rps18; CHL00077 272123014518 ribosomal protein L33; Region: rpl33; CHL00104 272123014519 RDD family; Region: RDD; pfam06271 272123014520 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123014521 endoglucanase; Region: PLN02420 272123014522 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 272123014523 Calx-beta domain; Region: Calx-beta; cl02522 272123014524 Calx-beta domain; Region: Calx-beta; pfam03160 272123014525 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272123014526 Calx-beta domain; Region: Calx-beta; pfam03160 272123014527 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272123014528 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272123014529 dimer interface [polypeptide binding]; other site 272123014530 putative functional site; other site 272123014531 putative MPT binding site; other site 272123014532 multidrug efflux protein NorA; Provisional; Region: PRK00187 272123014533 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272123014534 cation binding site [ion binding]; other site 272123014535 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 272123014536 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 272123014537 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272123014538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123014539 catalytic residue [active] 272123014540 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272123014541 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 272123014542 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272123014543 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272123014544 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 272123014545 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272123014546 RNA binding site [nucleotide binding]; other site 272123014547 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123014548 Uncharacterized conserved protein [Function unknown]; Region: COG1656 272123014549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123014550 ATP binding site [chemical binding]; other site 272123014551 Mg2+ binding site [ion binding]; other site 272123014552 G-X-G motif; other site 272123014553 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 272123014554 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123014555 Protein of unknown function (DUF433); Region: DUF433; pfam04255 272123014556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123014557 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272123014558 substrate binding site [chemical binding]; other site 272123014559 active site 272123014560 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 272123014561 Lipoxygenase; Region: Lipoxygenase; pfam00305 272123014562 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 272123014563 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123014564 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123014565 Ca2+ binding site [ion binding]; other site 272123014566 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123014567 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123014568 Ca2+ binding site [ion binding]; other site 272123014569 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123014570 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123014571 Ca2+ binding site [ion binding]; other site 272123014572 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123014573 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 272123014574 Ca2+ binding site [ion binding]; other site 272123014575 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 272123014576 Mnd1 family; Region: Mnd1; pfam03962 272123014577 glycogen synthase; Provisional; Region: glgA; PRK00654 272123014578 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272123014579 ADP-binding pocket [chemical binding]; other site 272123014580 homodimer interface [polypeptide binding]; other site 272123014581 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272123014582 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272123014583 domain interfaces; other site 272123014584 active site 272123014585 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123014586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123014587 metal binding site [ion binding]; metal-binding site 272123014588 active site 272123014589 I-site; other site 272123014590 putative lipid kinase; Reviewed; Region: PRK00861 272123014591 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272123014592 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 272123014593 BON domain; Region: BON; pfam04972 272123014594 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014595 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123014596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014598 TPR repeat; Region: TPR_11; pfam13414 272123014599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014600 binding surface 272123014601 TPR motif; other site 272123014602 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 272123014603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272123014604 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272123014605 dimerization interface [polypeptide binding]; other site 272123014606 substrate binding pocket [chemical binding]; other site 272123014607 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272123014608 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123014609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014610 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123014611 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014612 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014613 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272123014614 active site 272123014615 putative homodimer interface [polypeptide binding]; other site 272123014616 SAM binding site [chemical binding]; other site 272123014617 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 272123014618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014619 S-adenosylmethionine binding site [chemical binding]; other site 272123014620 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 272123014621 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272123014622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272123014623 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272123014624 threonine dehydratase; Reviewed; Region: PRK09224 272123014625 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272123014626 tetramer interface [polypeptide binding]; other site 272123014627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123014628 catalytic residue [active] 272123014629 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 272123014630 putative Ile/Val binding site [chemical binding]; other site 272123014631 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 272123014632 putative Ile/Val binding site [chemical binding]; other site 272123014633 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123014634 oligomeric interface; other site 272123014635 putative active site [active] 272123014636 homodimer interface [polypeptide binding]; other site 272123014637 Domain of unknown function DUF29; Region: DUF29; pfam01724 272123014638 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272123014639 Phosphoglycerate kinase; Region: PGK; pfam00162 272123014640 substrate binding site [chemical binding]; other site 272123014641 hinge regions; other site 272123014642 ADP binding site [chemical binding]; other site 272123014643 catalytic site [active] 272123014644 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272123014645 Ligand Binding Site [chemical binding]; other site 272123014646 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272123014647 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272123014648 active site 272123014649 catalytic site [active] 272123014650 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 272123014651 starch-binding site 2 [chemical binding]; other site 272123014652 starch-binding site 1 [chemical binding]; other site 272123014653 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 272123014654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123014655 Walker A/P-loop; other site 272123014656 ATP binding site [chemical binding]; other site 272123014657 Q-loop/lid; other site 272123014658 ABC transporter signature motif; other site 272123014659 Walker B; other site 272123014660 D-loop; other site 272123014661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123014662 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123014663 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 272123014664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123014665 FeS/SAM binding site; other site 272123014666 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272123014667 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272123014668 putative active site [active] 272123014669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272123014670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123014671 putative metal binding site [ion binding]; other site 272123014672 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123014673 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014675 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123014676 hypothetical protein; Reviewed; Region: PRK12497 272123014677 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272123014678 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272123014679 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272123014680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014681 binding surface 272123014682 TPR motif; other site 272123014683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014684 binding surface 272123014685 TPR motif; other site 272123014686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014687 binding surface 272123014688 TPR motif; other site 272123014689 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272123014690 TrkA-N domain; Region: TrkA_N; pfam02254 272123014691 TrkA-C domain; Region: TrkA_C; pfam02080 272123014692 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272123014693 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272123014694 tocopherol O-methyltransferase; Region: PLN02244 272123014695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014696 S-adenosylmethionine binding site [chemical binding]; other site 272123014697 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 272123014698 UbiA prenyltransferase family; Region: UbiA; pfam01040 272123014699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014700 binding surface 272123014701 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123014702 TPR motif; other site 272123014703 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123014704 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272123014705 active site 272123014706 SAM binding site [chemical binding]; other site 272123014707 homodimer interface [polypeptide binding]; other site 272123014708 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 272123014709 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272123014710 active site 272123014711 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272123014712 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272123014713 CoA-binding site [chemical binding]; other site 272123014714 ATP-binding [chemical binding]; other site 272123014715 Response regulator receiver domain; Region: Response_reg; pfam00072 272123014716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014717 active site 272123014718 phosphorylation site [posttranslational modification] 272123014719 intermolecular recognition site; other site 272123014720 dimerization interface [polypeptide binding]; other site 272123014721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123014722 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123014723 active site 272123014724 ATP binding site [chemical binding]; other site 272123014725 substrate binding site [chemical binding]; other site 272123014726 activation loop (A-loop); other site 272123014727 AAA ATPase domain; Region: AAA_16; pfam13191 272123014728 Predicted ATPase [General function prediction only]; Region: COG3899 272123014729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123014730 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123014731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123014732 dimer interface [polypeptide binding]; other site 272123014733 phosphorylation site [posttranslational modification] 272123014734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123014735 ATP binding site [chemical binding]; other site 272123014736 Mg2+ binding site [ion binding]; other site 272123014737 G-X-G motif; other site 272123014738 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123014739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123014740 active site 272123014741 phosphorylation site [posttranslational modification] 272123014742 intermolecular recognition site; other site 272123014743 dimerization interface [polypeptide binding]; other site 272123014744 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272123014745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123014746 metal binding site [ion binding]; metal-binding site 272123014747 active site 272123014748 I-site; other site 272123014749 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272123014750 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 272123014751 AAA-like domain; Region: AAA_10; pfam12846 272123014752 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 272123014753 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123014754 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123014755 active site 272123014756 ATP binding site [chemical binding]; other site 272123014757 substrate binding site [chemical binding]; other site 272123014758 activation loop (A-loop); other site 272123014759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272123014760 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014761 WD domain, G-beta repeat; Region: WD40; pfam00400 272123014762 WD40 repeats; Region: WD40; smart00320 272123014763 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014764 structural tetrad; other site 272123014765 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014766 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014767 structural tetrad; other site 272123014768 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272123014769 putative active site [active] 272123014770 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014771 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014772 structural tetrad; other site 272123014773 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014774 structural tetrad; other site 272123014775 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014776 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014777 structural tetrad; other site 272123014778 AAA ATPase domain; Region: AAA_16; pfam13191 272123014779 AAA domain; Region: AAA_22; pfam13401 272123014780 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272123014781 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272123014782 metal binding site [ion binding]; metal-binding site 272123014783 dimer interface [polypeptide binding]; other site 272123014784 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 272123014785 Hemerythrin-like domain; Region: Hr-like; cd12108 272123014786 Fe binding site [ion binding]; other site 272123014787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123014788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272123014789 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272123014790 Walker A/P-loop; other site 272123014791 ATP binding site [chemical binding]; other site 272123014792 Q-loop/lid; other site 272123014793 ABC transporter signature motif; other site 272123014794 Walker B; other site 272123014795 D-loop; other site 272123014796 H-loop/switch region; other site 272123014797 glutathione reductase; Validated; Region: PRK06116 272123014798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272123014799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123014800 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272123014801 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 272123014802 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272123014803 catalytic triad [active] 272123014804 dimer interface [polypeptide binding]; other site 272123014805 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272123014806 metal binding site 2 [ion binding]; metal-binding site 272123014807 putative DNA binding helix; other site 272123014808 metal binding site 1 [ion binding]; metal-binding site 272123014809 dimer interface [polypeptide binding]; other site 272123014810 structural Zn2+ binding site [ion binding]; other site 272123014811 mercuric reductase; Validated; Region: PRK06370 272123014812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272123014813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272123014814 short chain dehydrogenase; Provisional; Region: PRK06701 272123014815 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272123014816 NAD binding site [chemical binding]; other site 272123014817 metal binding site [ion binding]; metal-binding site 272123014818 active site 272123014819 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272123014820 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272123014821 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272123014822 putative Cl- selectivity filter; other site 272123014823 putative pore gating glutamate residue; other site 272123014824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014825 TPR motif; other site 272123014826 TPR repeat; Region: TPR_11; pfam13414 272123014827 binding surface 272123014828 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272123014829 Cytochrome c; Region: Cytochrom_C; pfam00034 272123014830 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 272123014831 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 272123014832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123014833 S-adenosylmethionine binding site [chemical binding]; other site 272123014834 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 272123014835 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272123014836 putative active site [active] 272123014837 oxyanion strand; other site 272123014838 catalytic triad [active] 272123014839 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 272123014840 putative substrate binding pocket [chemical binding]; other site 272123014841 AC domain interface; other site 272123014842 catalytic triad [active] 272123014843 AB domain interface; other site 272123014844 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 272123014845 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 272123014846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123014847 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123014848 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123014849 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123014850 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272123014851 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272123014852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272123014853 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 272123014854 Peptidase family M50; Region: Peptidase_M50; pfam02163 272123014855 active site 272123014856 putative substrate binding region [chemical binding]; other site 272123014857 FOG: CBS domain [General function prediction only]; Region: COG0517 272123014858 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 272123014859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014860 TPR repeat; Region: TPR_11; pfam13414 272123014861 binding surface 272123014862 TPR motif; other site 272123014863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014864 TPR repeat; Region: TPR_11; pfam13414 272123014865 binding surface 272123014866 TPR motif; other site 272123014867 TPR repeat; Region: TPR_11; pfam13414 272123014868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014869 binding surface 272123014870 TPR motif; other site 272123014871 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 272123014872 diiron binding motif [ion binding]; other site 272123014873 TM2 domain; Region: TM2; cl00984 272123014874 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 272123014875 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014876 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014877 structural tetrad; other site 272123014878 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123014879 structural tetrad; other site 272123014880 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123014881 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272123014882 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272123014883 MoaE interaction surface [polypeptide binding]; other site 272123014884 MoeB interaction surface [polypeptide binding]; other site 272123014885 thiocarboxylated glycine; other site 272123014886 threonine synthase; Validated; Region: PRK07591 272123014887 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 272123014888 homodimer interface [polypeptide binding]; other site 272123014889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123014890 catalytic residue [active] 272123014891 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272123014892 MoaE interaction surface [polypeptide binding]; other site 272123014893 MoeB interaction surface [polypeptide binding]; other site 272123014894 thiocarboxylated glycine; other site 272123014895 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272123014896 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272123014897 HSP70 interaction site [polypeptide binding]; other site 272123014898 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123014899 Clp protease; Region: CLP_protease; pfam00574 272123014900 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272123014901 oligomer interface [polypeptide binding]; other site 272123014902 active site residues [active] 272123014903 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272123014904 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272123014905 oligomer interface [polypeptide binding]; other site 272123014906 active site residues [active] 272123014907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014908 binding surface 272123014909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123014910 TPR motif; other site 272123014911 TPR repeat; Region: TPR_11; pfam13414 272123014912 CHAT domain; Region: CHAT; pfam12770 272123014913 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123014914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123014915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123014916 active site 272123014917 ATP binding site [chemical binding]; other site 272123014918 substrate binding site [chemical binding]; other site 272123014919 activation loop (A-loop); other site 272123014920 CHASE2 domain; Region: CHASE2; pfam05226 272123014921 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123014922 AAA ATPase domain; Region: AAA_16; pfam13191 272123014923 NB-ARC domain; Region: NB-ARC; pfam00931 272123014924 Calx-beta domain; Region: Calx-beta; cl02522 272123014925 Calx-beta domain; Region: Calx-beta; cl02522 272123014926 Calx-beta domain; Region: Calx-beta; cl02522 272123014927 Calx-beta domain; Region: Calx-beta; cl02522 272123014928 Cna protein B-type domain; Region: Cna_B; pfam05738 272123014929 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272123014930 active site 272123014931 catalytic residues [active] 272123014932 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123014933 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123014934 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 272123014935 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123014936 metal ion-dependent adhesion site (MIDAS); other site 272123014937 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 272123014938 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123014939 metal ion-dependent adhesion site (MIDAS); other site 272123014940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 272123014941 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272123014942 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 272123014943 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 272123014944 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272123014945 substrate binding site [chemical binding]; other site 272123014946 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272123014947 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272123014948 substrate binding site [chemical binding]; other site 272123014949 ligand binding site [chemical binding]; other site 272123014950 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272123014951 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272123014952 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272123014953 putative dimer interface [polypeptide binding]; other site 272123014954 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 272123014955 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123014956 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123014957 active site 272123014958 Predicted membrane protein [Function unknown]; Region: COG4327 272123014959 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272123014960 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272123014961 Na binding site [ion binding]; other site 272123014962 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272123014963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014964 binding surface 272123014965 TPR motif; other site 272123014966 TPR repeat; Region: TPR_11; pfam13414 272123014967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123014968 binding surface 272123014969 TPR motif; other site 272123014970 TPR repeat; Region: TPR_11; pfam13414 272123014971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123014972 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272123014973 catalytic site [active] 272123014974 putative active site [active] 272123014975 putative substrate binding site [chemical binding]; other site 272123014976 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 272123014977 Prostaglandin dehydrogenases; Region: PGDH; cd05288 272123014978 NAD(P) binding site [chemical binding]; other site 272123014979 substrate binding site [chemical binding]; other site 272123014980 dimer interface [polypeptide binding]; other site 272123014981 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 272123014982 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 272123014983 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123014984 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123014985 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272123014986 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272123014987 intersubunit interface [polypeptide binding]; other site 272123014988 active site 272123014989 zinc binding site [ion binding]; other site 272123014990 Na+ binding site [ion binding]; other site 272123014991 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 272123014992 nitrilase; Region: PLN02798 272123014993 putative active site [active] 272123014994 catalytic triad [active] 272123014995 dimer interface [polypeptide binding]; other site 272123014996 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272123014997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123014998 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123014999 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272123015000 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272123015001 CAAX protease self-immunity; Region: Abi; pfam02517 272123015002 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123015003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123015004 salt bridge; other site 272123015005 non-specific DNA binding site [nucleotide binding]; other site 272123015006 sequence-specific DNA binding site [nucleotide binding]; other site 272123015007 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272123015008 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272123015009 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123015010 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272123015011 Walker A/P-loop; other site 272123015012 ATP binding site [chemical binding]; other site 272123015013 Q-loop/lid; other site 272123015014 ABC transporter signature motif; other site 272123015015 Walker B; other site 272123015016 D-loop; other site 272123015017 H-loop/switch region; other site 272123015018 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272123015019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123015020 Walker A/P-loop; other site 272123015021 ATP binding site [chemical binding]; other site 272123015022 Q-loop/lid; other site 272123015023 ABC transporter signature motif; other site 272123015024 Walker B; other site 272123015025 D-loop; other site 272123015026 H-loop/switch region; other site 272123015027 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 272123015028 Subunit I/III interface [polypeptide binding]; other site 272123015029 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 272123015030 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272123015031 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272123015032 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272123015033 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272123015034 Predicted membrane protein [Function unknown]; Region: COG4244 272123015035 Predicted membrane protein [Function unknown]; Region: COG4244 272123015036 MAPEG family; Region: MAPEG; pfam01124 272123015037 DNA polymerase III subunit delta'; Validated; Region: PRK07399 272123015038 hypothetical protein; Reviewed; Region: PRK12275 272123015039 four helix bundle protein; Region: TIGR02436 272123015040 thymidylate kinase; Validated; Region: tmk; PRK00698 272123015041 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272123015042 TMP-binding site; other site 272123015043 ATP-binding site [chemical binding]; other site 272123015044 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272123015045 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272123015046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123015047 putative active site [active] 272123015048 heme pocket [chemical binding]; other site 272123015049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123015050 dimer interface [polypeptide binding]; other site 272123015051 phosphorylation site [posttranslational modification] 272123015052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015053 ATP binding site [chemical binding]; other site 272123015054 Mg2+ binding site [ion binding]; other site 272123015055 G-X-G motif; other site 272123015056 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 272123015057 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272123015058 C-terminal domain interface [polypeptide binding]; other site 272123015059 GSH binding site (G-site) [chemical binding]; other site 272123015060 dimer interface [polypeptide binding]; other site 272123015061 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 272123015062 N-terminal domain interface [polypeptide binding]; other site 272123015063 putative dimer interface [polypeptide binding]; other site 272123015064 active site 272123015065 Protein kinase domain; Region: Pkinase; pfam00069 272123015066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123015067 active site 272123015068 ATP binding site [chemical binding]; other site 272123015069 substrate binding site [chemical binding]; other site 272123015070 activation loop (A-loop); other site 272123015071 AAA ATPase domain; Region: AAA_16; pfam13191 272123015072 Predicted ATPase [General function prediction only]; Region: COG3899 272123015073 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123015074 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123015075 PAS fold; Region: PAS_4; pfam08448 272123015076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123015077 putative active site [active] 272123015078 heme pocket [chemical binding]; other site 272123015079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123015080 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272123015081 putative active site [active] 272123015082 heme pocket [chemical binding]; other site 272123015083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015084 ATP binding site [chemical binding]; other site 272123015085 Mg2+ binding site [ion binding]; other site 272123015086 G-X-G motif; other site 272123015087 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272123015088 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272123015089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272123015090 Uncharacterized conserved protein [Function unknown]; Region: COG4925 272123015091 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272123015092 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272123015093 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272123015094 classical (c) SDRs; Region: SDR_c; cd05233 272123015095 NAD(P) binding site [chemical binding]; other site 272123015096 active site 272123015097 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272123015098 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272123015099 Walker A/P-loop; other site 272123015100 ATP binding site [chemical binding]; other site 272123015101 Q-loop/lid; other site 272123015102 ABC transporter signature motif; other site 272123015103 Walker B; other site 272123015104 D-loop; other site 272123015105 H-loop/switch region; other site 272123015106 Protein kinase domain; Region: Pkinase; pfam00069 272123015107 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123015108 active site 272123015109 ATP binding site [chemical binding]; other site 272123015110 substrate binding site [chemical binding]; other site 272123015111 activation loop (A-loop); other site 272123015112 AAA ATPase domain; Region: AAA_16; pfam13191 272123015113 Predicted ATPase [General function prediction only]; Region: COG3899 272123015114 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272123015115 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123015116 GAF domain; Region: GAF_2; pfam13185 272123015117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123015118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015119 ATP binding site [chemical binding]; other site 272123015120 Mg2+ binding site [ion binding]; other site 272123015121 G-X-G motif; other site 272123015122 short chain dehydrogenase; Provisional; Region: PRK07109 272123015123 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 272123015124 putative NAD(P) binding site [chemical binding]; other site 272123015125 active site 272123015126 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272123015127 metal ion-dependent adhesion site (MIDAS); other site 272123015128 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 272123015129 ATP binding site [chemical binding]; other site 272123015130 substrate interface [chemical binding]; other site 272123015131 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 272123015132 putative active site [active] 272123015133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123015134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015135 active site 272123015136 phosphorylation site [posttranslational modification] 272123015137 intermolecular recognition site; other site 272123015138 dimerization interface [polypeptide binding]; other site 272123015139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123015140 DNA binding site [nucleotide binding] 272123015141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272123015142 dimerization interface [polypeptide binding]; other site 272123015143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123015144 dimer interface [polypeptide binding]; other site 272123015145 phosphorylation site [posttranslational modification] 272123015146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015147 ATP binding site [chemical binding]; other site 272123015148 Mg2+ binding site [ion binding]; other site 272123015149 G-X-G motif; other site 272123015150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272123015151 AMIN domain; Region: AMIN; pfam11741 272123015152 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272123015153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272123015154 N-terminal plug; other site 272123015155 ligand-binding site [chemical binding]; other site 272123015156 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272123015157 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272123015158 siderophore binding site; other site 272123015159 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 272123015160 putative dimer interface [polypeptide binding]; other site 272123015161 putative [2Fe-2S] cluster binding site [ion binding]; other site 272123015162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123015163 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123015164 putative substrate translocation pore; other site 272123015165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272123015166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272123015167 catalytic residue [active] 272123015168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272123015169 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 272123015170 inhibitor-cofactor binding pocket; inhibition site 272123015171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123015172 catalytic residue [active] 272123015173 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272123015174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123015175 S-adenosylmethionine binding site [chemical binding]; other site 272123015176 Condensation domain; Region: Condensation; pfam00668 272123015177 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015178 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123015179 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123015180 acyl-activating enzyme (AAE) consensus motif; other site 272123015181 AMP binding site [chemical binding]; other site 272123015182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015183 thioester reductase domain; Region: Thioester-redct; TIGR01746 272123015184 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 272123015185 putative NAD(P) binding site [chemical binding]; other site 272123015186 active site 272123015187 putative substrate binding site [chemical binding]; other site 272123015188 Condensation domain; Region: Condensation; pfam00668 272123015189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123015191 acyl-activating enzyme (AAE) consensus motif; other site 272123015192 AMP binding site [chemical binding]; other site 272123015193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015194 Condensation domain; Region: Condensation; pfam00668 272123015195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015196 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123015197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123015198 acyl-activating enzyme (AAE) consensus motif; other site 272123015199 AMP binding site [chemical binding]; other site 272123015200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015201 Condensation domain; Region: Condensation; pfam00668 272123015202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015203 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272123015204 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272123015205 acyl-activating enzyme (AAE) consensus motif; other site 272123015206 AMP binding site [chemical binding]; other site 272123015207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015208 Condensation domain; Region: Condensation; pfam00668 272123015209 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 272123015211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123015212 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272123015213 active site 272123015214 Acyl transferase domain; Region: Acyl_transf_1; cl08282 272123015215 Acyl transferase domain; Region: Acyl_transf_1; cl08282 272123015216 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272123015217 putative NADP binding site [chemical binding]; other site 272123015218 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272123015219 active site 272123015220 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272123015222 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272123015223 active site 272123015224 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272123015225 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272123015226 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272123015227 putative NADP binding site [chemical binding]; other site 272123015228 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272123015229 active site 272123015230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015231 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272123015232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272123015233 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 272123015234 acyl-activating enzyme (AAE) consensus motif; other site 272123015235 AMP binding site [chemical binding]; other site 272123015236 active site 272123015237 CoA binding site [chemical binding]; other site 272123015238 salicylate synthase; Region: salicyl_syn; TIGR03494 272123015239 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272123015240 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272123015241 dimer interface [polypeptide binding]; other site 272123015242 active site 272123015243 Condensation domain; Region: Condensation; pfam00668 272123015244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272123015245 Nonribosomal peptide synthase; Region: NRPS; pfam08415 272123015246 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 272123015247 acyl-activating enzyme (AAE) consensus motif; other site 272123015248 AMP binding site [chemical binding]; other site 272123015249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272123015250 Inclusion body protein; Region: PixA; pfam12306 272123015251 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 272123015252 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272123015253 ATP binding site [chemical binding]; other site 272123015254 Mg++ binding site [ion binding]; other site 272123015255 motif III; other site 272123015256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123015257 nucleotide binding region [chemical binding]; other site 272123015258 ATP-binding site [chemical binding]; other site 272123015259 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272123015260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123015261 NAD(P) binding site [chemical binding]; other site 272123015262 active site 272123015263 DNA photolyase; Region: DNA_photolyase; pfam00875 272123015264 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272123015265 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272123015266 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272123015267 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123015268 Dynamin family; Region: Dynamin_N; pfam00350 272123015269 G1 box; other site 272123015270 GTP/Mg2+ binding site [chemical binding]; other site 272123015271 G2 box; other site 272123015272 Switch I region; other site 272123015273 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 272123015274 G3 box; other site 272123015275 Switch II region; other site 272123015276 GTP/Mg2+ binding site [chemical binding]; other site 272123015277 G4 box; other site 272123015278 G5 box; other site 272123015279 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272123015280 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272123015281 dimerization interface [polypeptide binding]; other site 272123015282 ATP binding site [chemical binding]; other site 272123015283 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272123015284 dimerization interface [polypeptide binding]; other site 272123015285 ATP binding site [chemical binding]; other site 272123015286 amidophosphoribosyltransferase; Provisional; Region: PRK07349 272123015287 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272123015288 active site 272123015289 tetramer interface [polypeptide binding]; other site 272123015290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123015291 active site 272123015292 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272123015293 putative active site [active] 272123015294 homotetrameric interface [polypeptide binding]; other site 272123015295 metal binding site [ion binding]; metal-binding site 272123015296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123015297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123015298 active site 272123015299 ATP binding site [chemical binding]; other site 272123015300 substrate binding site [chemical binding]; other site 272123015301 activation loop (A-loop); other site 272123015302 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272123015303 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123015304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272123015305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123015306 dimer interface [polypeptide binding]; other site 272123015307 conserved gate region; other site 272123015308 putative PBP binding loops; other site 272123015309 ABC-ATPase subunit interface; other site 272123015310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272123015311 active site 272123015312 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 272123015313 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 272123015314 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272123015315 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272123015316 phosphopeptide binding site; other site 272123015317 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272123015318 Transglycosylase; Region: Transgly; pfam00912 272123015319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272123015320 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272123015321 lipoprotein signal peptidase; Provisional; Region: PRK14787 272123015322 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272123015323 PBP superfamily domain; Region: PBP_like_2; cl17296 272123015324 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272123015325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123015326 dimer interface [polypeptide binding]; other site 272123015327 conserved gate region; other site 272123015328 putative PBP binding loops; other site 272123015329 ABC-ATPase subunit interface; other site 272123015330 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272123015331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272123015332 dimer interface [polypeptide binding]; other site 272123015333 conserved gate region; other site 272123015334 putative PBP binding loops; other site 272123015335 ABC-ATPase subunit interface; other site 272123015336 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 272123015337 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272123015338 Walker A/P-loop; other site 272123015339 ATP binding site [chemical binding]; other site 272123015340 Q-loop/lid; other site 272123015341 ABC transporter signature motif; other site 272123015342 Walker B; other site 272123015343 D-loop; other site 272123015344 H-loop/switch region; other site 272123015345 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272123015346 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123015347 active site 272123015348 catalytic residues [active] 272123015349 DNA binding site [nucleotide binding] 272123015350 Int/Topo IB signature motif; other site 272123015351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272123015352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123015353 Coenzyme A binding pocket [chemical binding]; other site 272123015354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123015355 Coenzyme A binding pocket [chemical binding]; other site 272123015356 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 272123015357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272123015358 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272123015359 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 272123015360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123015361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123015362 non-specific DNA binding site [nucleotide binding]; other site 272123015363 salt bridge; other site 272123015364 sequence-specific DNA binding site [nucleotide binding]; other site 272123015365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272123015366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015367 active site 272123015368 phosphorylation site [posttranslational modification] 272123015369 intermolecular recognition site; other site 272123015370 dimerization interface [polypeptide binding]; other site 272123015371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123015372 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272123015373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123015374 GAF domain; Region: GAF; pfam01590 272123015375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123015376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123015377 dimer interface [polypeptide binding]; other site 272123015378 phosphorylation site [posttranslational modification] 272123015379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015380 ATP binding site [chemical binding]; other site 272123015381 Mg2+ binding site [ion binding]; other site 272123015382 G-X-G motif; other site 272123015383 Response regulator receiver domain; Region: Response_reg; pfam00072 272123015384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015385 active site 272123015386 phosphorylation site [posttranslational modification] 272123015387 intermolecular recognition site; other site 272123015388 dimerization interface [polypeptide binding]; other site 272123015389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272123015390 cyclase homology domain; Region: CHD; cd07302 272123015391 nucleotidyl binding site; other site 272123015392 metal binding site [ion binding]; metal-binding site 272123015393 dimer interface [polypeptide binding]; other site 272123015394 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272123015395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123015396 Coenzyme A binding pocket [chemical binding]; other site 272123015397 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 272123015398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272123015399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123015400 homodimer interface [polypeptide binding]; other site 272123015401 catalytic residue [active] 272123015402 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 272123015403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272123015404 FecR protein; Region: FecR; pfam04773 272123015405 Protein of unknown function (DUF560); Region: DUF560; pfam04575 272123015406 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272123015407 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272123015408 active site residue [active] 272123015409 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272123015410 active site residue [active] 272123015411 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 272123015412 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 272123015413 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272123015414 Substrate binding site; other site 272123015415 Mg++ binding site; other site 272123015416 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272123015417 active site 272123015418 substrate binding site [chemical binding]; other site 272123015419 CoA binding site [chemical binding]; other site 272123015420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123015421 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123015422 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 272123015423 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 272123015424 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 272123015425 active site 272123015426 dimer interface [polypeptide binding]; other site 272123015427 catalytic nucleophile [active] 272123015428 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 272123015429 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123015430 GAF domain; Region: GAF; pfam01590 272123015431 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272123015432 GAF domain; Region: GAF; pfam01590 272123015433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123015434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015435 ATP binding site [chemical binding]; other site 272123015436 Mg2+ binding site [ion binding]; other site 272123015437 G-X-G motif; other site 272123015438 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272123015439 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272123015440 quinone interaction residues [chemical binding]; other site 272123015441 active site 272123015442 catalytic residues [active] 272123015443 FMN binding site [chemical binding]; other site 272123015444 substrate binding site [chemical binding]; other site 272123015445 Membrane transport protein; Region: Mem_trans; cl09117 272123015446 TROVE domain; Region: TROVE; pfam05731 272123015447 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272123015448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123015449 FeS/SAM binding site; other site 272123015450 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123015451 oligomeric interface; other site 272123015452 putative active site [active] 272123015453 homodimer interface [polypeptide binding]; other site 272123015454 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272123015455 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272123015456 ring oligomerisation interface [polypeptide binding]; other site 272123015457 ATP/Mg binding site [chemical binding]; other site 272123015458 stacking interactions; other site 272123015459 hinge regions; other site 272123015460 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272123015461 oligomerisation interface [polypeptide binding]; other site 272123015462 mobile loop; other site 272123015463 roof hairpin; other site 272123015464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123015465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015466 active site 272123015467 phosphorylation site [posttranslational modification] 272123015468 intermolecular recognition site; other site 272123015469 dimerization interface [polypeptide binding]; other site 272123015470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123015471 DNA binding residues [nucleotide binding] 272123015472 dimerization interface [polypeptide binding]; other site 272123015473 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123015474 putative active site [active] 272123015475 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272123015476 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272123015477 putative dimer interface [polypeptide binding]; other site 272123015478 putative anticodon binding site; other site 272123015479 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272123015480 homodimer interface [polypeptide binding]; other site 272123015481 motif 1; other site 272123015482 motif 2; other site 272123015483 active site 272123015484 motif 3; other site 272123015485 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272123015486 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272123015487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272123015488 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 272123015489 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 272123015490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123015491 S-adenosylmethionine binding site [chemical binding]; other site 272123015492 Phycobilisome protein; Region: Phycobilisome; cl08227 272123015493 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 272123015494 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272123015495 alpha-gamma subunit interface [polypeptide binding]; other site 272123015496 beta-gamma subunit interface [polypeptide binding]; other site 272123015497 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272123015498 gamma-beta subunit interface [polypeptide binding]; other site 272123015499 alpha-beta subunit interface [polypeptide binding]; other site 272123015500 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272123015501 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272123015502 subunit interactions [polypeptide binding]; other site 272123015503 active site 272123015504 flap region; other site 272123015505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015506 active site 272123015507 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272123015508 phosphorylation site [posttranslational modification] 272123015509 intermolecular recognition site; other site 272123015510 dimerization interface [polypeptide binding]; other site 272123015511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272123015512 dimer interface [polypeptide binding]; other site 272123015513 phosphorylation site [posttranslational modification] 272123015514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015515 ATP binding site [chemical binding]; other site 272123015516 Mg2+ binding site [ion binding]; other site 272123015517 G-X-G motif; other site 272123015518 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 272123015519 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 272123015520 NAD(P) binding site [chemical binding]; other site 272123015521 catalytic residues [active] 272123015522 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123015523 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272123015524 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272123015525 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272123015526 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272123015527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123015528 Walker A motif; other site 272123015529 ATP binding site [chemical binding]; other site 272123015530 Walker B motif; other site 272123015531 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272123015532 Clp protease; Region: CLP_protease; pfam00574 272123015533 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272123015534 oligomer interface [polypeptide binding]; other site 272123015535 active site residues [active] 272123015536 trigger factor; Provisional; Region: tig; PRK01490 272123015537 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272123015538 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272123015539 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272123015540 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272123015541 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272123015542 dihydrodipicolinate synthase; Region: dapA; TIGR00674 272123015543 dimer interface [polypeptide binding]; other site 272123015544 active site 272123015545 catalytic residue [active] 272123015546 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272123015547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272123015548 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272123015549 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272123015550 Dynamin family; Region: Dynamin_N; pfam00350 272123015551 G1 box; other site 272123015552 GTP/Mg2+ binding site [chemical binding]; other site 272123015553 G2 box; other site 272123015554 Switch I region; other site 272123015555 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272123015556 G3 box; other site 272123015557 Switch II region; other site 272123015558 GTP/Mg2+ binding site [chemical binding]; other site 272123015559 G4 box; other site 272123015560 G5 box; other site 272123015561 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 272123015562 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272123015563 transmembrane helices; other site 272123015564 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 272123015565 MutS domain III; Region: MutS_III; pfam05192 272123015566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123015567 Walker A/P-loop; other site 272123015568 ATP binding site [chemical binding]; other site 272123015569 Q-loop/lid; other site 272123015570 ABC transporter signature motif; other site 272123015571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123015572 Walker B; other site 272123015573 D-loop; other site 272123015574 H-loop/switch region; other site 272123015575 Smr domain; Region: Smr; pfam01713 272123015576 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 272123015577 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 272123015578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298 272123015579 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 272123015580 Ycf35; Provisional; Region: ycf35; CHL00193 272123015581 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 272123015582 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272123015583 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272123015584 heterotetramer interface [polypeptide binding]; other site 272123015585 active site pocket [active] 272123015586 cleavage site 272123015587 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272123015588 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272123015589 GatB domain; Region: GatB_Yqey; pfam02637 272123015590 agmatinase; Region: agmatinase; TIGR01230 272123015591 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 272123015592 putative active site [active] 272123015593 Mn binding site [ion binding]; other site 272123015594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123015595 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272123015596 active site 272123015597 metal binding site [ion binding]; metal-binding site 272123015598 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 272123015599 Lipase (class 2); Region: Lipase_2; pfam01674 272123015600 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123015601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123015602 binding surface 272123015603 TPR motif; other site 272123015604 RNA methyltransferase, RsmE family; Region: TIGR00046 272123015605 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 272123015606 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 272123015607 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 272123015608 active site 272123015609 zinc binding site [ion binding]; other site 272123015610 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 272123015611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272123015612 Coenzyme A binding pocket [chemical binding]; other site 272123015613 ferredoxin-sulfite reductase; Region: sir; TIGR02042 272123015614 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123015615 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272123015616 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 272123015617 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123015618 DNA-binding interface [nucleotide binding]; DNA binding site 272123015619 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272123015620 trimer interface [polypeptide binding]; other site 272123015621 active site 272123015622 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272123015623 trimer interface [polypeptide binding]; other site 272123015624 active site 272123015625 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272123015626 trimer interface [polypeptide binding]; other site 272123015627 active site 272123015628 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272123015629 dimerization interface [polypeptide binding]; other site 272123015630 active site 272123015631 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 272123015632 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 272123015633 PAS fold; Region: PAS_4; pfam08448 272123015634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272123015635 putative active site [active] 272123015636 heme pocket [chemical binding]; other site 272123015637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272123015638 metal binding site [ion binding]; metal-binding site 272123015639 active site 272123015640 I-site; other site 272123015641 light-harvesting-like protein 3; Provisional; Region: PLN00014 272123015642 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 272123015643 putative catalytic residue [active] 272123015644 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272123015645 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272123015646 hinge; other site 272123015647 active site 272123015648 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 272123015649 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272123015650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272123015651 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 272123015652 acyl-activating enzyme (AAE) consensus motif; other site 272123015653 acyl-activating enzyme (AAE) consensus motif; other site 272123015654 putative AMP binding site [chemical binding]; other site 272123015655 putative active site [active] 272123015656 putative CoA binding site [chemical binding]; other site 272123015657 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272123015658 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272123015659 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272123015660 DAK2 domain; Region: Dak2; cl03685 272123015661 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 272123015662 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272123015663 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272123015664 active site 272123015665 catalytic residues [active] 272123015666 metal binding site [ion binding]; metal-binding site 272123015667 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272123015668 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272123015669 protein binding site [polypeptide binding]; other site 272123015670 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123015671 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 272123015672 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 272123015673 XisI protein; Region: XisI; pfam08869 272123015674 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272123015675 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 272123015676 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272123015677 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272123015678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123015679 nucleotide binding region [chemical binding]; other site 272123015680 ATP-binding site [chemical binding]; other site 272123015681 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 272123015682 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272123015683 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272123015684 active site 272123015685 ATP binding site [chemical binding]; other site 272123015686 substrate binding site [chemical binding]; other site 272123015687 activation loop (A-loop); other site 272123015688 AAA domain; Region: AAA_11; pfam13086 272123015689 Part of AAA domain; Region: AAA_19; pfam13245 272123015690 AAA domain; Region: AAA_30; pfam13604 272123015691 AAA domain; Region: AAA_12; pfam13087 272123015692 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 272123015693 putative active site [active] 272123015694 putative catalytic site [active] 272123015695 DNA polymerase III subunit delta; Validated; Region: PRK07452 272123015696 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272123015697 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 272123015698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123015699 Walker A motif; other site 272123015700 ATP binding site [chemical binding]; other site 272123015701 Walker B motif; other site 272123015702 arginine finger; other site 272123015703 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272123015704 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123015705 putative active site [active] 272123015706 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272123015707 DNA polymerase III subunit beta; Validated; Region: PRK05643 272123015708 putative DNA binding surface [nucleotide binding]; other site 272123015709 dimer interface [polypeptide binding]; other site 272123015710 beta-clamp/clamp loader binding surface; other site 272123015711 beta-clamp/translesion DNA polymerase binding surface; other site 272123015712 AAA domain; Region: AAA_30; pfam13604 272123015713 AAA domain; Region: AAA_22; pfam13401 272123015714 Protein of unknown function (DUF511); Region: DUF511; cl01114 272123015715 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 272123015716 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 272123015717 WYL domain; Region: WYL; cl14852 272123015718 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 272123015719 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 272123015720 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 272123015721 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 272123015722 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 272123015723 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 272123015724 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 272123015725 CRISPR-associated protein; Region: TIGR03986 272123015726 RAMP superfamily; Region: RAMPs; pfam03787 272123015727 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 272123015728 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 272123015729 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 272123015730 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 272123015731 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 272123015732 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272123015733 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 272123015734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123015735 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272123015736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272123015737 AAA-like domain; Region: AAA_10; pfam12846 272123015738 ATP-dependent protease Lon; Provisional; Region: PRK13765 272123015739 V-type ATP synthase subunit I; Validated; Region: PRK05771 272123015740 RNA dependent RNA polymerase; Region: RdRP; pfam05183 272123015741 FemAB family; Region: FemAB; pfam02388 272123015742 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272123015743 SNF2 Helicase protein; Region: DUF3670; pfam12419 272123015744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272123015745 ATP binding site [chemical binding]; other site 272123015746 putative Mg++ binding site [ion binding]; other site 272123015747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123015748 nucleotide binding region [chemical binding]; other site 272123015749 ATP-binding site [chemical binding]; other site 272123015750 Uncharacterized conserved protein [Function unknown]; Region: COG4279 272123015751 SWIM zinc finger; Region: SWIM; pfam04434 272123015752 Response regulator receiver domain; Region: Response_reg; pfam00072 272123015753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015754 active site 272123015755 phosphorylation site [posttranslational modification] 272123015756 intermolecular recognition site; other site 272123015757 dimerization interface [polypeptide binding]; other site 272123015758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123015759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123015760 dimer interface [polypeptide binding]; other site 272123015761 phosphorylation site [posttranslational modification] 272123015762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123015763 ATP binding site [chemical binding]; other site 272123015764 Mg2+ binding site [ion binding]; other site 272123015765 G-X-G motif; other site 272123015766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123015767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123015768 active site 272123015769 phosphorylation site [posttranslational modification] 272123015770 intermolecular recognition site; other site 272123015771 dimerization interface [polypeptide binding]; other site 272123015772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123015773 DNA binding residues [nucleotide binding] 272123015774 dimerization interface [polypeptide binding]; other site 272123015775 AAA ATPase domain; Region: AAA_16; pfam13191 272123015776 Archaeal ATPase; Region: Arch_ATPase; pfam01637 272123015777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015779 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272123015780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272123015781 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 272123015782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 272123015783 Uncharacterized conserved protein [Function unknown]; Region: COG2442 272123015784 YcfA-like protein; Region: YcfA; pfam07927 272123015785 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272123015786 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123015787 oligomeric interface; other site 272123015788 putative active site [active] 272123015789 homodimer interface [polypeptide binding]; other site 272123015790 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 272123015791 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272123015792 glycerol kinase; Provisional; Region: glpK; PRK00047 272123015793 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 272123015794 N- and C-terminal domain interface [polypeptide binding]; other site 272123015795 active site 272123015796 MgATP binding site [chemical binding]; other site 272123015797 catalytic site [active] 272123015798 metal binding site [ion binding]; metal-binding site 272123015799 putative homotetramer interface [polypeptide binding]; other site 272123015800 glycerol binding site [chemical binding]; other site 272123015801 homodimer interface [polypeptide binding]; other site 272123015802 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 272123015803 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 272123015804 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 272123015805 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272123015806 Mg binding site [ion binding]; other site 272123015807 nucleotide binding site [chemical binding]; other site 272123015808 putative protofilament interface [polypeptide binding]; other site 272123015809 conjugal transfer protein TraL; Provisional; Region: PRK13886 272123015810 Predicted ATPase [General function prediction only]; Region: COG4637 272123015811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123015812 Walker A/P-loop; other site 272123015813 ATP binding site [chemical binding]; other site 272123015814 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272123015815 active site 272123015816 NTP binding site [chemical binding]; other site 272123015817 metal binding triad [ion binding]; metal-binding site 272123015818 antibiotic binding site [chemical binding]; other site 272123015819 RRXRR protein; Region: RRXRR; pfam14239 272123015820 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123015821 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123015822 active site 272123015823 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123015824 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123015825 active site 272123015826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272123015827 Probable transposase; Region: OrfB_IS605; pfam01385 272123015828 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272123015829 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 272123015830 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272123015831 Ycf46; Provisional; Region: ycf46; CHL00195 272123015832 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 272123015833 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123015834 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123015835 active site 272123015836 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272123015837 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123015838 active site 272123015839 Int/Topo IB signature motif; other site 272123015840 DNA binding site [nucleotide binding] 272123015841 plasmid segregation protein ParM; Provisional; Region: PRK13917 272123015842 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272123015843 Mg binding site [ion binding]; other site 272123015844 nucleotide binding site [chemical binding]; other site 272123015845 putative protofilament interface [polypeptide binding]; other site 272123015846 ParB-like nuclease domain; Region: ParBc; pfam02195 272123015847 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123015848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123015849 P-loop; other site 272123015850 Magnesium ion binding site [ion binding]; other site 272123015851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123015852 Magnesium ion binding site [ion binding]; other site 272123015853 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272123015854 DNA binding site [nucleotide binding] 272123015855 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123015857 binding surface 272123015858 TPR motif; other site 272123015859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123015862 binding surface 272123015863 TPR motif; other site 272123015864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015865 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015867 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123015868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123015869 TPR motif; other site 272123015870 binding surface 272123015871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015872 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015873 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015874 Tetratricopeptide repeat; Region: TPR_10; pfam13374 272123015875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123015877 binding surface 272123015878 TPR motif; other site 272123015879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123015880 CHAT domain; Region: CHAT; pfam12770 272123015881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123015882 non-specific DNA binding site [nucleotide binding]; other site 272123015883 salt bridge; other site 272123015884 sequence-specific DNA binding site [nucleotide binding]; other site 272123015885 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 272123015886 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272123015887 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272123015888 putative active site [active] 272123015889 putative NTP binding site [chemical binding]; other site 272123015890 putative nucleic acid binding site [nucleotide binding]; other site 272123015891 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 272123015892 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 272123015893 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 272123015894 four helix bundle protein; Region: TIGR02436 272123015895 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272123015896 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123015897 CRISPR-associated protein; Region: DUF3692; pfam12469 272123015898 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 272123015899 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 272123015900 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 272123015901 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 272123015902 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123015903 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272123015904 active site 272123015905 CARDB; Region: CARDB; pfam07705 272123015906 CARDB; Region: CARDB; pfam07705 272123015907 CARDB; Region: CARDB; pfam07705 272123015908 CARDB; Region: CARDB; pfam07705 272123015909 CARDB; Region: CARDB; pfam07705 272123015910 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 272123015911 CARDB; Region: CARDB; pfam07705 272123015912 CARDB; Region: CARDB; pfam07705 272123015913 CARDB; Region: CARDB; pfam07705 272123015914 CARDB; Region: CARDB; pfam07705 272123015915 CARDB; Region: CARDB; pfam07705 272123015916 CARDB; Region: CARDB; pfam07705 272123015917 CARDB; Region: CARDB; pfam07705 272123015918 CARDB; Region: CARDB; pfam07705 272123015919 CARDB; Region: CARDB; pfam07705 272123015920 CARDB; Region: CARDB; pfam07705 272123015921 CARDB; Region: CARDB; pfam07705 272123015922 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 272123015923 Bacterial Ig-like domain; Region: Big_5; pfam13205 272123015924 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123015925 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123015926 RHS Repeat; Region: RHS_repeat; pfam05593 272123015927 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 272123015928 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272123015929 active site 272123015930 substrate binding site [chemical binding]; other site 272123015931 Mg2+ binding site [ion binding]; other site 272123015932 FOG: PKD repeat [General function prediction only]; Region: COG3291 272123015933 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272123015934 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272123015935 FOG: PKD repeat [General function prediction only]; Region: COG3291 272123015936 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272123015937 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272123015938 Calx-beta domain; Region: Calx-beta; cl02522 272123015939 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 272123015940 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 272123015941 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272123015942 putative active site [active] 272123015943 putative NTP binding site [chemical binding]; other site 272123015944 putative nucleic acid binding site [nucleotide binding]; other site 272123015945 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272123015946 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272123015947 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272123015948 active site 272123015949 Predicted transcription factor, homolog of eukaryotic MBF1 [Transcription]; Region: COG1813 272123015950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123015951 non-specific DNA binding site [nucleotide binding]; other site 272123015952 salt bridge; other site 272123015953 sequence-specific DNA binding site [nucleotide binding]; other site 272123015954 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272123015955 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 272123015956 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123015957 active site 272123015958 catalytic residues [active] 272123015959 DNA binding site [nucleotide binding] 272123015960 Int/Topo IB signature motif; other site 272123015961 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 272123015962 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 272123015963 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 272123015964 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 272123015965 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272123015966 active site 272123015967 catalytic site [active] 272123015968 substrate binding site [chemical binding]; other site 272123015969 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 272123015970 active site 272123015971 DNA binding site [nucleotide binding] 272123015972 catalytic site [active] 272123015973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123015974 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123015975 P-loop; other site 272123015976 Magnesium ion binding site [ion binding]; other site 272123015977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123015978 Magnesium ion binding site [ion binding]; other site 272123015979 Predicted membrane protein [Function unknown]; Region: COG2259 272123015980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123015981 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123015982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272123015983 FeS/SAM binding site; other site 272123015984 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272123015985 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272123015986 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 272123015987 active site 272123015988 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272123015989 RAMP superfamily; Region: RAMPs; pfam03787 272123015990 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123015991 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 272123015992 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 272123015993 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 272123015994 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 272123015995 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 272123015996 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 272123015997 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272123015998 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 272123015999 WYL domain; Region: WYL; pfam13280 272123016000 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 272123016001 Putative transcription activator [Transcription]; Region: TenA; COG0819 272123016002 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272123016003 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123016004 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016005 active site 272123016006 catalytic residues [active] 272123016007 DNA binding site [nucleotide binding] 272123016008 Int/Topo IB signature motif; other site 272123016009 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 272123016010 CHAT domain; Region: CHAT; pfam12770 272123016011 SPX domain; Region: SPX; pfam03105 272123016012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123016013 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272123016014 Walker A motif; other site 272123016015 ATP binding site [chemical binding]; other site 272123016016 Walker B motif; other site 272123016017 arginine finger; other site 272123016018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 272123016019 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272123016020 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123016021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123016022 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123016023 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272123016024 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272123016025 ParG; Region: ParG; pfam09274 272123016026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016027 non-specific DNA binding site [nucleotide binding]; other site 272123016028 salt bridge; other site 272123016029 sequence-specific DNA binding site [nucleotide binding]; other site 272123016030 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123016031 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016034 Catalase-related immune-responsive; Region: Catalase-rel; pfam06628 272123016035 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 272123016036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272123016037 salt bridge; other site 272123016038 non-specific DNA binding site [nucleotide binding]; other site 272123016039 sequence-specific DNA binding site [nucleotide binding]; other site 272123016040 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 272123016041 Antirestriction protein (ArdA); Region: ArdA; cl01953 272123016042 hypothetical protein; Provisional; Region: PRK04262 272123016043 Staphylococcal nuclease homologues; Region: SNc; smart00318 272123016044 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 272123016045 Catalytic site; other site 272123016046 O-Antigen ligase; Region: Wzy_C; pfam04932 272123016047 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123016048 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123016049 catalytic residues [active] 272123016050 catalytic nucleophile [active] 272123016051 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123016052 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123016053 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123016054 Synaptic Site I dimer interface [polypeptide binding]; other site 272123016055 DNA binding site [nucleotide binding] 272123016056 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123016057 DNA-binding interface [nucleotide binding]; DNA binding site 272123016058 Integrase core domain; Region: rve; pfam00665 272123016059 Integrase core domain; Region: rve_3; cl15866 272123016060 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123016061 thymidylate kinase; Validated; Region: tmk; PRK00698 272123016062 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272123016063 TMP-binding site; other site 272123016064 ATP-binding site [chemical binding]; other site 272123016065 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272123016066 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123016067 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016068 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272123016069 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016071 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016072 DNA binding site [nucleotide binding] 272123016073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123016074 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016075 DNA binding site [nucleotide binding] 272123016076 active site 272123016077 Int/Topo IB signature motif; other site 272123016078 catalytic residues [active] 272123016079 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016080 DNA binding site [nucleotide binding] 272123016081 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016082 DNA binding site [nucleotide binding] 272123016083 active site 272123016084 Int/Topo IB signature motif; other site 272123016085 catalytic residues [active] 272123016086 AAA domain; Region: AAA_25; pfam13481 272123016087 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272123016088 Walker A motif; other site 272123016089 ATP binding site [chemical binding]; other site 272123016090 Walker B motif; other site 272123016091 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272123016092 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272123016093 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272123016094 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123016095 putative active site [active] 272123016096 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123016097 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272123016098 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272123016099 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272123016100 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272123016101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123016102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123016103 ATP binding site [chemical binding]; other site 272123016104 putative Mg++ binding site [ion binding]; other site 272123016105 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 272123016106 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 272123016107 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016108 P-loop; other site 272123016109 Magnesium ion binding site [ion binding]; other site 272123016110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016111 Magnesium ion binding site [ion binding]; other site 272123016112 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016113 active site 272123016114 catalytic residues [active] 272123016115 DNA binding site [nucleotide binding] 272123016116 Int/Topo IB signature motif; other site 272123016117 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123016118 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123016119 catalytic residues [active] 272123016120 catalytic nucleophile [active] 272123016121 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123016122 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123016123 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123016124 Synaptic Site I dimer interface [polypeptide binding]; other site 272123016125 DNA binding site [nucleotide binding] 272123016126 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123016127 DNA-binding interface [nucleotide binding]; DNA binding site 272123016128 Integrase core domain; Region: rve; pfam00665 272123016129 Integrase core domain; Region: rve_3; cl15866 272123016130 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123016131 Caspase domain; Region: Peptidase_C14; pfam00656 272123016132 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 272123016133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272123016134 AAA-like domain; Region: AAA_10; pfam12846 272123016135 Walker A motif; other site 272123016136 ATP binding site [chemical binding]; other site 272123016137 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272123016138 Walker B motif; other site 272123016139 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272123016140 AAA domain; Region: AAA_22; pfam13401 272123016141 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 272123016142 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123016143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123016144 structural tetrad; other site 272123016145 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272123016146 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272123016147 structural tetrad; other site 272123016148 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123016149 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016150 P-loop; other site 272123016151 Magnesium ion binding site [ion binding]; other site 272123016152 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016153 Magnesium ion binding site [ion binding]; other site 272123016154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272123016155 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272123016156 ParB-like nuclease domain; Region: ParB; smart00470 272123016157 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 272123016158 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272123016159 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123016160 oligomeric interface; other site 272123016161 putative active site [active] 272123016162 homodimer interface [polypeptide binding]; other site 272123016163 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 272123016164 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272123016165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123016166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016167 salt bridge; other site 272123016168 non-specific DNA binding site [nucleotide binding]; other site 272123016169 sequence-specific DNA binding site [nucleotide binding]; other site 272123016170 Double zinc ribbon; Region: DZR; pfam12773 272123016171 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272123016172 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123016173 active site 272123016174 DNA binding site [nucleotide binding] 272123016175 Int/Topo IB signature motif; other site 272123016176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272123016177 nucleotide binding site [chemical binding]; other site 272123016178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272123016179 G1 box; other site 272123016180 GTP/Mg2+ binding site [chemical binding]; other site 272123016181 G2 box; other site 272123016182 G3 box; other site 272123016183 Switch II region; other site 272123016184 G4 box; other site 272123016185 G5 box; other site 272123016186 Domain of unknown function (DUF697); Region: DUF697; cl12064 272123016187 GUN4-like; Region: GUN4; pfam05419 272123016188 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272123016189 G1 box; other site 272123016190 GTP/Mg2+ binding site [chemical binding]; other site 272123016191 G2 box; other site 272123016192 Switch I region; other site 272123016193 G3 box; other site 272123016194 Switch II region; other site 272123016195 AAA-like domain; Region: AAA_10; pfam12846 272123016196 Protein of unknown function (DUF692); Region: DUF692; cl01263 272123016197 Protein of unknown function (DUF692); Region: DUF692; cl01263 272123016198 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 272123016199 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 272123016200 CHAT domain; Region: CHAT; cl17868 272123016201 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 272123016202 CHASE2 domain; Region: CHASE2; pfam05226 272123016203 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 272123016204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272123016205 binding surface 272123016206 TPR motif; other site 272123016207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123016208 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272123016209 Tetratricopeptide repeats; Region: TPR; smart00028 272123016210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123016211 TPR motif; other site 272123016212 binding surface 272123016213 CHAT domain; Region: CHAT; cl17868 272123016214 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 272123016215 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272123016216 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272123016217 inhibitor-cofactor binding pocket; inhibition site 272123016218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123016219 catalytic residue [active] 272123016220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272123016221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272123016222 NAD(P) binding site [chemical binding]; other site 272123016223 active site 272123016224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272123016225 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 272123016226 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272123016227 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272123016228 NAD binding site [chemical binding]; other site 272123016229 homodimer interface [polypeptide binding]; other site 272123016230 active site 272123016231 substrate binding site [chemical binding]; other site 272123016232 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272123016233 dimer interface [polypeptide binding]; other site 272123016234 ADP-ribose binding site [chemical binding]; other site 272123016235 active site 272123016236 nudix motif; other site 272123016237 metal binding site [ion binding]; metal-binding site 272123016238 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 272123016239 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272123016240 Surface antigen; Region: Bac_surface_Ag; pfam01103 272123016241 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123016242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016243 P-loop; other site 272123016244 Magnesium ion binding site [ion binding]; other site 272123016245 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016246 Magnesium ion binding site [ion binding]; other site 272123016247 ParB-like nuclease domain; Region: ParBc; pfam02195 272123016248 Part of AAA domain; Region: AAA_19; pfam13245 272123016249 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272123016250 AAA domain; Region: AAA_12; pfam13087 272123016251 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 272123016252 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 272123016253 ArsC family; Region: ArsC; pfam03960 272123016254 catalytic residue [active] 272123016255 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272123016256 oligomeric interface; other site 272123016257 putative active site [active] 272123016258 homodimer interface [polypeptide binding]; other site 272123016259 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123016260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016261 non-specific DNA binding site [nucleotide binding]; other site 272123016262 salt bridge; other site 272123016263 sequence-specific DNA binding site [nucleotide binding]; other site 272123016264 Domain of unknown function (DUF955); Region: DUF955; cl01076 272123016265 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016266 active site 272123016267 catalytic residues [active] 272123016268 DNA binding site [nucleotide binding] 272123016269 Int/Topo IB signature motif; other site 272123016270 Helix-turn-helix domain; Region: HTH_28; pfam13518 272123016271 Winged helix-turn helix; Region: HTH_29; pfam13551 272123016272 Homeodomain-like domain; Region: HTH_32; pfam13565 272123016273 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272123016274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272123016275 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016276 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016277 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016278 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016279 Ca2+ binding site [ion binding]; other site 272123016280 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016281 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016282 Ca2+ binding site [ion binding]; other site 272123016283 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016284 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016285 Ca2+ binding site [ion binding]; other site 272123016286 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016287 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016288 Ca2+ binding site [ion binding]; other site 272123016289 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016290 Ca2+ binding site [ion binding]; other site 272123016291 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016292 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016293 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016294 Ca2+ binding site [ion binding]; other site 272123016295 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272123016296 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 272123016297 Integrase core domain; Region: rve; pfam00665 272123016298 Integrase core domain; Region: rve_3; cl15866 272123016299 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272123016300 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272123016301 catalytic residues [active] 272123016302 catalytic nucleophile [active] 272123016303 Presynaptic Site I dimer interface [polypeptide binding]; other site 272123016304 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272123016305 Synaptic Flat tetramer interface [polypeptide binding]; other site 272123016306 Synaptic Site I dimer interface [polypeptide binding]; other site 272123016307 DNA binding site [nucleotide binding] 272123016308 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272123016309 DNA-binding interface [nucleotide binding]; DNA binding site 272123016310 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272123016311 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272123016312 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272123016313 active site 272123016314 catalytic residues [active] 272123016315 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 272123016316 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123016317 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272123016318 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016319 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016320 Ca2+ binding site [ion binding]; other site 272123016321 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272123016322 Cadherin repeat-like domain; Region: CA_like; cl15786 272123016323 Ca2+ binding site [ion binding]; other site 272123016324 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016325 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016326 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016327 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 272123016328 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 272123016329 T5orf172 domain; Region: T5orf172; pfam10544 272123016330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272123016331 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272123016332 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016333 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016335 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272123016336 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016337 active site 272123016338 catalytic residues [active] 272123016339 DNA binding site [nucleotide binding] 272123016340 Int/Topo IB signature motif; other site 272123016341 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272123016342 Competence protein CoiA-like family; Region: CoiA; cl11541 272123016343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123016344 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 272123016345 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272123016346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016347 non-specific DNA binding site [nucleotide binding]; other site 272123016348 salt bridge; other site 272123016349 sequence-specific DNA binding site [nucleotide binding]; other site 272123016350 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 272123016351 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123016352 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016353 P-loop; other site 272123016354 Magnesium ion binding site [ion binding]; other site 272123016355 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 272123016356 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016357 active site 272123016358 catalytic residues [active] 272123016359 DNA binding site [nucleotide binding] 272123016360 Int/Topo IB signature motif; other site 272123016361 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 272123016362 Predicted ATPase [General function prediction only]; Region: COG4637 272123016363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123016364 Walker A/P-loop; other site 272123016365 ATP binding site [chemical binding]; other site 272123016366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123016367 ABC transporter signature motif; other site 272123016368 Walker B; other site 272123016369 D-loop; other site 272123016370 H-loop/switch region; other site 272123016371 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 272123016372 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272123016373 catalytic site [active] 272123016374 PLD-like domain; Region: PLDc_2; pfam13091 272123016375 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272123016376 putative active site [active] 272123016377 catalytic site [active] 272123016378 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272123016379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272123016380 putative Mg++ binding site [ion binding]; other site 272123016381 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272123016382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272123016383 nucleotide binding region [chemical binding]; other site 272123016384 ATP-binding site [chemical binding]; other site 272123016385 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272123016386 active site 272123016387 catalytic residues [active] 272123016388 DNA binding site [nucleotide binding] 272123016389 Int/Topo IB signature motif; other site 272123016390 AIPR protein; Region: AIPR; pfam10592 272123016391 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272123016392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123016393 dimer interface [polypeptide binding]; other site 272123016394 phosphorylation site [posttranslational modification] 272123016395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123016396 ATP binding site [chemical binding]; other site 272123016397 Mg2+ binding site [ion binding]; other site 272123016398 G-X-G motif; other site 272123016399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123016400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123016401 active site 272123016402 phosphorylation site [posttranslational modification] 272123016403 intermolecular recognition site; other site 272123016404 dimerization interface [polypeptide binding]; other site 272123016405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123016406 DNA binding site [nucleotide binding] 272123016407 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272123016408 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272123016409 dimer interface [polypeptide binding]; other site 272123016410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272123016411 catalytic residue [active] 272123016412 Progressive ankylosis protein (ANKH); Region: ANKH; pfam07260 272123016413 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 272123016414 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 272123016415 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 272123016416 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 272123016417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123016418 dimer interface [polypeptide binding]; other site 272123016419 phosphorylation site [posttranslational modification] 272123016420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123016421 ATP binding site [chemical binding]; other site 272123016422 Mg2+ binding site [ion binding]; other site 272123016423 G-X-G motif; other site 272123016424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123016425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123016426 active site 272123016427 phosphorylation site [posttranslational modification] 272123016428 intermolecular recognition site; other site 272123016429 dimerization interface [polypeptide binding]; other site 272123016430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123016431 DNA binding site [nucleotide binding] 272123016432 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123016433 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 272123016434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123016435 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123016436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123016437 DNA binding residues [nucleotide binding] 272123016438 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272123016439 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 272123016440 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272123016441 Protein export membrane protein; Region: SecD_SecF; cl14618 272123016442 S-layer homology domain; Region: SLH; pfam00395 272123016443 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272123016444 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272123016445 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 272123016446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272123016447 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272123016448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272123016449 DNA binding residues [nucleotide binding] 272123016450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272123016451 putative active site [active] 272123016452 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272123016453 HlyD family secretion protein; Region: HlyD_2; pfam12700 272123016454 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272123016455 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123016456 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272123016457 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 272123016458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272123016459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272123016460 dimer interface [polypeptide binding]; other site 272123016461 phosphorylation site [posttranslational modification] 272123016462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272123016463 ATP binding site [chemical binding]; other site 272123016464 Mg2+ binding site [ion binding]; other site 272123016465 G-X-G motif; other site 272123016466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272123016467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123016468 active site 272123016469 phosphorylation site [posttranslational modification] 272123016470 intermolecular recognition site; other site 272123016471 dimerization interface [polypeptide binding]; other site 272123016472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272123016473 DNA binding site [nucleotide binding] 272123016474 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 272123016475 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272123016476 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272123016477 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272123016478 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272123016479 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 272123016480 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272123016481 DNA binding residues [nucleotide binding] 272123016482 dimer interface [polypeptide binding]; other site 272123016483 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 272123016484 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 272123016485 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272123016486 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123016487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272123016488 motif II; other site 272123016489 H+ Antiporter protein; Region: 2A0121; TIGR00900 272123016490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272123016491 putative substrate translocation pore; other site 272123016492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 272123016493 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272123016494 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123016495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272123016496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272123016497 active site 272123016498 phosphorylation site [posttranslational modification] 272123016499 intermolecular recognition site; other site 272123016500 dimerization interface [polypeptide binding]; other site 272123016501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272123016502 DNA binding residues [nucleotide binding] 272123016503 dimerization interface [polypeptide binding]; other site 272123016504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016505 non-specific DNA binding site [nucleotide binding]; other site 272123016506 salt bridge; other site 272123016507 sequence-specific DNA binding site [nucleotide binding]; other site 272123016508 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272123016509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016510 non-specific DNA binding site [nucleotide binding]; other site 272123016511 salt bridge; other site 272123016512 sequence-specific DNA binding site [nucleotide binding]; other site 272123016513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272123016514 non-specific DNA binding site [nucleotide binding]; other site 272123016515 salt bridge; other site 272123016516 sequence-specific DNA binding site [nucleotide binding]; other site 272123016517 Predicted transcriptional regulators [Transcription]; Region: COG1695 272123016518 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272123016519 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272123016520 putative active site [active] 272123016521 acetyl-CoA acetyltransferase; Provisional; Region: PRK06445 272123016522 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 272123016523 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272123016524 Mg binding site [ion binding]; other site 272123016525 nucleotide binding site [chemical binding]; other site 272123016526 putative protofilament interface [polypeptide binding]; other site 272123016527 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 272123016528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123016529 S-adenosylmethionine binding site [chemical binding]; other site 272123016530 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 272123016531 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272123016532 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 272123016533 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272123016534 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 272123016535 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 272123016536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123016537 Walker A motif; other site 272123016538 ATP binding site [chemical binding]; other site 272123016539 Walker B motif; other site 272123016540 arginine finger; other site 272123016541 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 272123016542 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 272123016543 TPR repeat; Region: TPR_11; pfam13414 272123016544 Tetratricopeptide repeat; Region: TPR_1; pfam00515 272123016545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272123016546 binding surface 272123016547 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272123016548 TPR motif; other site 272123016549 TPR repeat; Region: TPR_11; pfam13414 272123016550 manganese transport protein MntH; Reviewed; Region: PRK00701 272123016551 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272123016552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272123016553 putative DNA binding site [nucleotide binding]; other site 272123016554 dimerization interface [polypeptide binding]; other site 272123016555 putative Zn2+ binding site [ion binding]; other site 272123016556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272123016557 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272123016558 metal-binding site [ion binding] 272123016559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272123016560 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272123016561 metal-binding site [ion binding] 272123016562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123016563 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 272123016564 ParB-like nuclease domain; Region: ParBc; pfam02195 272123016565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272123016566 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016567 P-loop; other site 272123016568 Magnesium ion binding site [ion binding]; other site 272123016569 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272123016570 Magnesium ion binding site [ion binding]; other site 272123016571 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272123016572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272123016573 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272123016574 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272123016575 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272123016576 dimer interface [polypeptide binding]; other site 272123016577 ssDNA binding site [nucleotide binding]; other site 272123016578 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272123016579 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 272123016580 DNA polymerase III subunit delta'; Validated; Region: PRK07399 272123016581 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272123016582 DNA polymerase III subunit delta; Validated; Region: PRK07452 272123016583 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272123016584 AAA domain; Region: AAA_23; pfam13476 272123016585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272123016586 Walker A/P-loop; other site 272123016587 ATP binding site [chemical binding]; other site 272123016588 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272123016589 active site 272123016590 catalytic site [active] 272123016591 substrate binding site [chemical binding]; other site 272123016592 DNA polymerase type-B family; Region: POLBc; smart00486 272123016593 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 272123016594 active site 272123016595 metal-binding site 272123016596 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 272123016597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123016598 Walker A motif; other site 272123016599 ATP binding site [chemical binding]; other site 272123016600 Walker B motif; other site 272123016601 arginine finger; other site 272123016602 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272123016603 DNA polymerase III subunit beta; Validated; Region: PRK05643 272123016604 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272123016605 putative DNA binding surface [nucleotide binding]; other site 272123016606 dimer interface [polypeptide binding]; other site 272123016607 beta-clamp/clamp loader binding surface; other site 272123016608 beta-clamp/translesion DNA polymerase binding surface; other site 272123016609 regulatory ATPase RavA; Provisional; Region: PRK13531 272123016610 Phage-related protein [Function unknown]; Region: COG4695; cl01923 272123016611 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 272123016612 ATP binding site [chemical binding]; other site 272123016613 substrate interface [chemical binding]; other site 272123016614 PRTRC system protein A; Region: PRTRC_A; TIGR03735 272123016615 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 272123016616 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 272123016617 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 272123016618 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 272123016619 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 272123016620 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 272123016621 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 272123016622 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 272123016623 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 272123016624 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272123016625 AAA-like domain; Region: AAA_10; pfam12846 272123016626 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272123016627 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 272123016628 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 272123016629 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 272123016630 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 272123016631 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272123016632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272123016633 Walker A motif; other site 272123016634 ATP binding site [chemical binding]; other site 272123016635 Walker B motif; other site 272123016636 arginine finger; other site 272123016637 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 272123016638 putative active site [active] 272123016639 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272123016640 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272123016641 DNA binding site [nucleotide binding] 272123016642 AAA domain; Region: AAA_30; pfam13604 272123016643 Family description; Region: UvrD_C_2; pfam13538 272123016644 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272123016645 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272123016646 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272123016647 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272123016648 HlyD family secretion protein; Region: HlyD_3; pfam13437 272123016649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272123016650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272123016651 S-adenosylmethionine binding site [chemical binding]; other site 272123016652 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 272123016653 DNA binding residues [nucleotide binding] 272123016654 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 272123016655 dimer interface [polypeptide binding]; other site 272123016656 metal binding site [ion binding]; metal-binding site 272123016657 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 272123016658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272123016659 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272123016660 active site 272123016661 metal binding site [ion binding]; metal-binding site 272123016662 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 272123016663 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272123016664 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272123016665 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272123016666 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272123016667 metal-binding site [ion binding] 272123016668 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272123016669 Soluble P-type ATPase [General function prediction only]; Region: COG4087