-- dump date   	20140618_203603
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
240292000001	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
240292000002	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292000003	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
240292000004	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292000005	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292000006	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292000007	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292000008	GUN4-like; Region: GUN4; pfam05419
240292000009	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
240292000010	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292000011	Zn binding site [ion binding]; other site
240292000012	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292000013	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292000014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292000015	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292000016	active site
240292000017	substrate binding site [chemical binding]; other site
240292000018	ATP binding site [chemical binding]; other site
240292000019	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292000020	activation loop (A-loop); other site
240292000021	TPR repeat; Region: TPR_11; pfam13414
240292000022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000023	binding surface
240292000024	TPR motif; other site
240292000025	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292000026	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000027	binding surface
240292000028	TPR motif; other site
240292000029	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292000030	AAA ATPase domain; Region: AAA_16; pfam13191
240292000031	NACHT domain; Region: NACHT; pfam05729
240292000032	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
240292000033	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292000034	active site
240292000035	DNA binding site [nucleotide binding]
240292000036	Int/Topo IB signature motif; other site
240292000037	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
240292000038	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
240292000039	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
240292000040	putative active site [active]
240292000041	putative NTP binding site [chemical binding]; other site
240292000042	putative nucleic acid binding site [nucleotide binding]; other site
240292000043	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
240292000044	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292000045	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292000046	active site
240292000047	AAA-like domain; Region: AAA_10; pfam12846
240292000048	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240292000049	Walker B motif; other site
240292000050	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
240292000051	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
240292000052	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
240292000053	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
240292000054	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292000055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292000056	ATP binding site [chemical binding]; other site
240292000057	Mg2+ binding site [ion binding]; other site
240292000058	G-X-G motif; other site
240292000059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292000060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292000061	active site
240292000062	phosphorylation site [posttranslational modification]
240292000063	intermolecular recognition site; other site
240292000064	dimerization interface [polypeptide binding]; other site
240292000065	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292000066	DNA binding residues [nucleotide binding]
240292000067	dimerization interface [polypeptide binding]; other site
240292000068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292000069	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292000070	Walker A/P-loop; other site
240292000071	ATP binding site [chemical binding]; other site
240292000072	Uncharacterized conserved protein [Function unknown]; Region: COG1430
240292000073	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
240292000074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000075	Walker A motif; other site
240292000076	ATP binding site [chemical binding]; other site
240292000077	Walker B motif; other site
240292000078	arginine finger; other site
240292000079	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
240292000080	Homeodomain-like domain; Region: HTH_23; pfam13384
240292000081	Winged helix-turn helix; Region: HTH_29; pfam13551
240292000082	Winged helix-turn helix; Region: HTH_33; pfam13592
240292000083	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000084	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
240292000085	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
240292000086	putative protofilament interface [polypeptide binding]; other site
240292000087	nucleotide binding site [chemical binding]; other site
240292000088	AIPR protein; Region: AIPR; pfam10592
240292000089	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292000090	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
240292000091	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292000092	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292000093	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292000094	DNA binding residues [nucleotide binding]
240292000095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292000096	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292000097	Coenzyme A binding pocket [chemical binding]; other site
240292000098	MOSC domain; Region: MOSC; pfam03473
240292000099	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
240292000100	DNA binding site [nucleotide binding]
240292000101	active site
240292000102	SprT-like family; Region: SprT-like; pfam10263
240292000103	RRXRR protein; Region: RRXRR; pfam14239
240292000104	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292000105	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292000106	active site
240292000107	Uncharacterized conserved protein [Function unknown]; Region: COG3791
240292000108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292000109	hypothetical protein; Region: PHA01733
240292000110	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
240292000111	putative dimer interface [polypeptide binding]; other site
240292000112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292000113	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
240292000114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000115	AAA domain; Region: AAA_22; pfam13401
240292000116	Walker A motif; other site
240292000117	ATP binding site [chemical binding]; other site
240292000118	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292000119	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292000120	Integrase core domain; Region: rve; pfam00665
240292000121	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292000122	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
240292000123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292000124	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
240292000125	dimerization interface [polypeptide binding]; other site
240292000126	substrate binding pocket [chemical binding]; other site
240292000127	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
240292000128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292000129	ATP binding site [chemical binding]; other site
240292000130	putative Mg++ binding site [ion binding]; other site
240292000131	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292000132	nucleotide binding region [chemical binding]; other site
240292000133	ATP-binding site [chemical binding]; other site
240292000134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000135	Probable transposase; Region: OrfB_IS605; pfam01385
240292000136	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000137	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
240292000138	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292000139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000140	Probable transposase; Region: OrfB_IS605; pfam01385
240292000141	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
240292000142	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
240292000143	DNA binding residues [nucleotide binding]
240292000144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
240292000145	non-specific DNA binding site [nucleotide binding]; other site
240292000146	salt bridge; other site
240292000147	sequence-specific DNA binding site [nucleotide binding]; other site
240292000148	KilA-N domain; Region: KilA-N; pfam04383
240292000149	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292000150	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
240292000151	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
240292000152	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
240292000153	Mrr N-terminal domain; Region: Mrr_N; pfam14338
240292000154	Restriction endonuclease; Region: Mrr_cat; pfam04471
240292000155	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
240292000156	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292000157	putative active site [active]
240292000158	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292000159	structural tetrad; other site
240292000160	PQQ-like domain; Region: PQQ_2; pfam13360
240292000161	HNH endonuclease; Region: HNH_3; pfam13392
240292000162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000163	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292000164	Probable transposase; Region: OrfB_IS605; pfam01385
240292000165	Transposase IS200 like; Region: Y1_Tnp; pfam01797
240292000166	AIPR protein; Region: AIPR; pfam10592
240292000167	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
240292000168	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
240292000169	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
240292000170	Sulfate transporter family; Region: Sulfate_transp; pfam00916
240292000171	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
240292000172	RelB antitoxin; Region: RelB; cl01171
240292000173	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292000174	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
240292000175	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292000176	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292000177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292000178	motif II; other site
240292000179	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292000180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240292000181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292000182	S-adenosylmethionine binding site [chemical binding]; other site
240292000183	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
240292000184	Helicase_C-like; Region: Helicase_C_4; pfam13871
240292000185	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
240292000186	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292000187	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292000188	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292000189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292000190	DNA binding residues [nucleotide binding]
240292000191	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
240292000192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000193	Walker A motif; other site
240292000194	ATP binding site [chemical binding]; other site
240292000195	Walker B motif; other site
240292000196	arginine finger; other site
240292000197	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
240292000198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240292000199	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
240292000200	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
240292000201	ParB-like nuclease domain; Region: ParBc; pfam02195
240292000202	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292000203	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292000204	P-loop; other site
240292000205	Magnesium ion binding site [ion binding]; other site
240292000206	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292000207	Magnesium ion binding site [ion binding]; other site
240292000208	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
240292000209	Mg binding site [ion binding]; other site
240292000210	nucleotide binding site [chemical binding]; other site
240292000211	putative protofilament interface [polypeptide binding]; other site
240292000212	Integrase core domain; Region: rve; pfam00665
240292000213	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292000214	AAA domain; Region: AAA_22; pfam13401
240292000215	AAA domain; Region: AAA_13; pfam13166
240292000216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000217	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292000218	Probable transposase; Region: OrfB_IS605; pfam01385
240292000219	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000220	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
240292000221	DNA binding residues [nucleotide binding]
240292000222	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292000223	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
240292000224	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240292000225	substrate binding site [chemical binding]; other site
240292000226	activation loop (A-loop); other site
240292000227	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292000228	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292000229	structural tetrad; other site
240292000230	Protein phosphatase 2C; Region: PP2C_2; pfam13672
240292000231	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
240292000232	metal ion-dependent adhesion site (MIDAS); other site
240292000233	HNH endonuclease; Region: HNH_5; pfam14279
240292000234	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292000235	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
240292000236	active site
240292000237	DNA binding site [nucleotide binding]
240292000238	Int/Topo IB signature motif; other site
240292000239	Deoxyhypusine synthase; Region: DS; cl00826
240292000240	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
240292000241	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
240292000242	TPR repeat; Region: TPR_11; pfam13414
240292000243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000244	TPR motif; other site
240292000245	binding surface
240292000246	TPR repeat; Region: TPR_11; pfam13414
240292000247	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292000248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292000249	TPR repeat; Region: TPR_11; pfam13414
240292000250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000251	binding surface
240292000252	TPR motif; other site
240292000253	AMIN domain; Region: AMIN; pfam11741
240292000254	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000255	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000256	N-terminal plug; other site
240292000257	ligand-binding site [chemical binding]; other site
240292000258	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
240292000259	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
240292000260	putative ligand binding residues [chemical binding]; other site
240292000261	AMIN domain; Region: AMIN; pfam11741
240292000262	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000263	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000264	N-terminal plug; other site
240292000265	ligand-binding site [chemical binding]; other site
240292000266	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
240292000267	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
240292000268	putative ligand binding residues [chemical binding]; other site
240292000269	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
240292000270	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292000271	ABC-ATPase subunit  interface; other site
240292000272	dimer interface [polypeptide binding]; other site
240292000273	putative PBP binding regions; other site
240292000274	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
240292000275	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
240292000276	Walker A/P-loop; other site
240292000277	ATP binding site [chemical binding]; other site
240292000278	Q-loop/lid; other site
240292000279	ABC transporter signature motif; other site
240292000280	Walker B; other site
240292000281	D-loop; other site
240292000282	H-loop/switch region; other site
240292000283	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
240292000284	light-harvesting-like protein 3; Provisional; Region: PLN00014
240292000285	Homeodomain-like domain; Region: HTH_23; pfam13384
240292000286	Winged helix-turn helix; Region: HTH_29; pfam13551
240292000287	Winged helix-turn helix; Region: HTH_33; pfam13592
240292000288	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000289	Predicted metal-binding protein [Function unknown]; Region: COG5469
240292000290	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
240292000291	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000292	N-terminal plug; other site
240292000293	ligand-binding site [chemical binding]; other site
240292000294	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
240292000295	dimer interface [polypeptide binding]; other site
240292000296	[2Fe-2S] cluster binding site [ion binding]; other site
240292000297	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
240292000298	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
240292000299	putative ligand binding site [chemical binding]; other site
240292000300	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
240292000301	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
240292000302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292000303	dimer interface [polypeptide binding]; other site
240292000304	putative PBP binding regions; other site
240292000305	ABC-ATPase subunit  interface; other site
240292000306	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
240292000307	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
240292000308	Walker A/P-loop; other site
240292000309	ATP binding site [chemical binding]; other site
240292000310	Q-loop/lid; other site
240292000311	ABC transporter signature motif; other site
240292000312	Walker B; other site
240292000313	D-loop; other site
240292000314	H-loop/switch region; other site
240292000315	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
240292000316	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292000317	inhibitor-cofactor binding pocket; inhibition site
240292000318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292000319	catalytic residue [active]
240292000320	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
240292000321	deoxyhypusine synthase; Region: dhys; TIGR00321
240292000322	FeoA domain; Region: FeoA; pfam04023
240292000323	FeoA domain; Region: FeoA; pfam04023
240292000324	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
240292000325	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
240292000326	G1 box; other site
240292000327	GTP/Mg2+ binding site [chemical binding]; other site
240292000328	Switch I region; other site
240292000329	G2 box; other site
240292000330	G3 box; other site
240292000331	Switch II region; other site
240292000332	G4 box; other site
240292000333	G5 box; other site
240292000334	Nucleoside recognition; Region: Gate; pfam07670
240292000335	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
240292000336	Nucleoside recognition; Region: Gate; pfam07670
240292000337	FeoC like transcriptional regulator; Region: FeoC; pfam09012
240292000338	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292000339	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
240292000340	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
240292000341	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
240292000342	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
240292000343	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
240292000344	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
240292000345	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
240292000346	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
240292000347	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
240292000348	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240292000349	Subunit I/III interface [polypeptide binding]; other site
240292000350	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240292000351	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
240292000352	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292000353	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
240292000354	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240292000355	Predicted membrane protein [Function unknown]; Region: COG4244
240292000356	Predicted membrane protein [Function unknown]; Region: COG4244
240292000357	Predicted transcriptional regulator [Transcription]; Region: COG3682
240292000358	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
240292000359	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
240292000360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292000361	putative substrate translocation pore; other site
240292000362	AMIN domain; Region: AMIN; pfam11741
240292000363	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000364	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000365	N-terminal plug; other site
240292000366	ligand-binding site [chemical binding]; other site
240292000367	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292000368	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
240292000369	active site
240292000370	DNA binding site [nucleotide binding]
240292000371	Int/Topo IB signature motif; other site
240292000372	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
240292000373	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
240292000374	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
240292000375	Ligand Binding Site [chemical binding]; other site
240292000376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292000377	Response regulator receiver domain; Region: Response_reg; pfam00072
240292000378	active site
240292000379	phosphorylation site [posttranslational modification]
240292000380	intermolecular recognition site; other site
240292000381	dimerization interface [polypeptide binding]; other site
240292000382	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292000383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292000384	dimer interface [polypeptide binding]; other site
240292000385	phosphorylation site [posttranslational modification]
240292000386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292000387	ATP binding site [chemical binding]; other site
240292000388	Mg2+ binding site [ion binding]; other site
240292000389	G-X-G motif; other site
240292000390	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292000391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292000392	active site
240292000393	phosphorylation site [posttranslational modification]
240292000394	intermolecular recognition site; other site
240292000395	dimerization interface [polypeptide binding]; other site
240292000396	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292000397	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292000398	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292000399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292000400	TrkA-C domain; Region: TrkA_C; pfam02080
240292000401	hypothetical protein; Provisional; Region: PRK02237
240292000402	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
240292000403	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
240292000404	Ligand Binding Site [chemical binding]; other site
240292000405	S-layer homology domain; Region: SLH; pfam00395
240292000406	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292000407	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292000408	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292000409	active site
240292000410	ATP binding site [chemical binding]; other site
240292000411	substrate binding site [chemical binding]; other site
240292000412	activation loop (A-loop); other site
240292000413	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
240292000414	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
240292000415	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292000416	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292000417	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
240292000418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292000419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292000420	dimer interface [polypeptide binding]; other site
240292000421	phosphorylation site [posttranslational modification]
240292000422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292000423	ATP binding site [chemical binding]; other site
240292000424	Mg2+ binding site [ion binding]; other site
240292000425	G-X-G motif; other site
240292000426	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292000427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292000428	active site
240292000429	phosphorylation site [posttranslational modification]
240292000430	intermolecular recognition site; other site
240292000431	dimerization interface [polypeptide binding]; other site
240292000432	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292000433	DNA binding residues [nucleotide binding]
240292000434	dimerization interface [polypeptide binding]; other site
240292000435	T5orf172 domain; Region: T5orf172; cl17462
240292000436	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292000437	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292000438	Walker A/P-loop; other site
240292000439	ATP binding site [chemical binding]; other site
240292000440	Q-loop/lid; other site
240292000441	ABC transporter signature motif; other site
240292000442	Walker B; other site
240292000443	D-loop; other site
240292000444	H-loop/switch region; other site
240292000445	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
240292000446	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292000447	Walker A/P-loop; other site
240292000448	ATP binding site [chemical binding]; other site
240292000449	Q-loop/lid; other site
240292000450	ABC transporter signature motif; other site
240292000451	Walker B; other site
240292000452	D-loop; other site
240292000453	H-loop/switch region; other site
240292000454	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
240292000455	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
240292000456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292000457	dimer interface [polypeptide binding]; other site
240292000458	conserved gate region; other site
240292000459	putative PBP binding loops; other site
240292000460	ABC-ATPase subunit interface; other site
240292000461	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
240292000462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292000463	dimer interface [polypeptide binding]; other site
240292000464	conserved gate region; other site
240292000465	putative PBP binding loops; other site
240292000466	ABC-ATPase subunit interface; other site
240292000467	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
240292000468	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
240292000469	AMIN domain; Region: AMIN; pfam11741
240292000470	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000471	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000472	N-terminal plug; other site
240292000473	ligand-binding site [chemical binding]; other site
240292000474	AMIN domain; Region: AMIN; pfam11741
240292000475	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000476	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000477	N-terminal plug; other site
240292000478	ligand-binding site [chemical binding]; other site
240292000479	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
240292000480	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
240292000481	putative PBP binding regions; other site
240292000482	Homeodomain-like domain; Region: HTH_23; pfam13384
240292000483	Winged helix-turn helix; Region: HTH_29; pfam13551
240292000484	Winged helix-turn helix; Region: HTH_33; pfam13592
240292000485	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000486	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
240292000487	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
240292000488	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
240292000489	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
240292000490	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
240292000491	metal binding site [ion binding]; metal-binding site
240292000492	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
240292000493	dimer interface [polypeptide binding]; other site
240292000494	active site
240292000495	aspartate-rich active site metal binding site; other site
240292000496	allosteric magnesium binding site [ion binding]; other site
240292000497	Schiff base residues; other site
240292000498	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
240292000499	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
240292000500	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
240292000501	active site
240292000502	dimer interface [polypeptide binding]; other site
240292000503	motif 1; other site
240292000504	motif 2; other site
240292000505	motif 3; other site
240292000506	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
240292000507	anticodon binding site; other site
240292000508	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
240292000509	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
240292000510	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
240292000511	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292000512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292000513	S-adenosylmethionine binding site [chemical binding]; other site
240292000514	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
240292000515	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292000516	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
240292000517	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292000518	active site
240292000519	metal binding site [ion binding]; metal-binding site
240292000520	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292000521	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
240292000522	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292000523	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292000524	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
240292000525	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292000526	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
240292000527	putative active site [active]
240292000528	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292000529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292000530	Walker A/P-loop; other site
240292000531	ATP binding site [chemical binding]; other site
240292000532	Q-loop/lid; other site
240292000533	ABC transporter signature motif; other site
240292000534	Walker B; other site
240292000535	D-loop; other site
240292000536	H-loop/switch region; other site
240292000537	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
240292000538	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
240292000539	active site
240292000540	zinc binding site [ion binding]; other site
240292000541	S-layer homology domain; Region: SLH; pfam00395
240292000542	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292000543	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
240292000545	Homeodomain-like domain; Region: HTH_23; pfam13384
240292000546	Winged helix-turn helix; Region: HTH_29; pfam13551
240292000547	Homeodomain-like domain; Region: HTH_32; pfam13565
240292000548	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
240292000549	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
240292000550	DNA binding site [nucleotide binding]
240292000551	AAA domain; Region: AAA_30; pfam13604
240292000552	Family description; Region: UvrD_C_2; pfam13538
240292000553	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292000554	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
240292000555	DNA binding residues [nucleotide binding]
240292000556	Homeodomain-like domain; Region: HTH_23; pfam13384
240292000557	Winged helix-turn helix; Region: HTH_29; pfam13551
240292000558	Winged helix-turn helix; Region: HTH_33; pfam13592
240292000559	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000560	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
240292000561	active site
240292000562	catalytic site [active]
240292000563	substrate binding site [chemical binding]; other site
240292000564	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
240292000565	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
240292000566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000567	Walker A motif; other site
240292000568	ATP binding site [chemical binding]; other site
240292000569	Walker B motif; other site
240292000570	arginine finger; other site
240292000571	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
240292000572	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
240292000573	non-specific DNA binding site [nucleotide binding]; other site
240292000574	salt bridge; other site
240292000575	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
240292000576	sequence-specific DNA binding site [nucleotide binding]; other site
240292000577	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
240292000578	active site
240292000579	metal binding site [ion binding]; metal-binding site
240292000580	interdomain interaction site; other site
240292000581	Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399
240292000582	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
240292000583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
240292000584	ATP binding site [chemical binding]; other site
240292000585	putative Mg++ binding site [ion binding]; other site
240292000586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292000587	nucleotide binding region [chemical binding]; other site
240292000588	ATP-binding site [chemical binding]; other site
240292000589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000590	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292000591	Probable transposase; Region: OrfB_IS605; pfam01385
240292000592	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000593	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
240292000594	active site
240292000595	catalytic site [active]
240292000596	substrate binding site [chemical binding]; other site
240292000597	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
240292000598	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
240292000599	Excalibur calcium-binding domain; Region: Excalibur; cl05460
240292000600	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
240292000601	Staphylococcal nuclease homologues; Region: SNc; smart00318
240292000602	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
240292000603	Catalytic site; other site
240292000604	Excalibur calcium-binding domain; Region: Excalibur; cl05460
240292000605	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
240292000606	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
240292000607	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
240292000608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000609	binding surface
240292000610	TPR motif; other site
240292000611	TPR repeat; Region: TPR_11; pfam13414
240292000612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000613	binding surface
240292000614	TPR motif; other site
240292000615	TPR repeat; Region: TPR_11; pfam13414
240292000616	TPR repeat; Region: TPR_11; pfam13414
240292000617	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292000618	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240292000619	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240292000620	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292000621	catalytic residue [active]
240292000622	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
240292000623	PLD-like domain; Region: PLDc_2; pfam13091
240292000624	putative homodimer interface [polypeptide binding]; other site
240292000625	putative active site [active]
240292000626	catalytic site [active]
240292000627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292000628	ATP binding site [chemical binding]; other site
240292000629	Mg2+ binding site [ion binding]; other site
240292000630	G-X-G motif; other site
240292000631	DEAD-like helicases superfamily; Region: DEXDc; smart00487
240292000632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292000633	ATP binding site [chemical binding]; other site
240292000634	putative Mg++ binding site [ion binding]; other site
240292000635	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292000636	nucleotide binding region [chemical binding]; other site
240292000637	ATP-binding site [chemical binding]; other site
240292000638	DNA-sulfur modification-associated; Region: DndB; cl17621
240292000639	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
240292000640	active site
240292000641	GIY-YIG motif/motif A; other site
240292000642	catalytic site [active]
240292000643	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240292000644	Active Sites [active]
240292000645	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
240292000646	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
240292000647	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
240292000648	Mg binding site [ion binding]; other site
240292000649	nucleotide binding site [chemical binding]; other site
240292000650	putative protofilament interface [polypeptide binding]; other site
240292000651	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
240292000652	catalytic residue [active]
240292000653	H2TH interface [polypeptide binding]; other site
240292000654	putative catalytic residues [active]
240292000655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292000656	non-specific DNA binding site [nucleotide binding]; other site
240292000657	salt bridge; other site
240292000658	sequence-specific DNA binding site [nucleotide binding]; other site
240292000659	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
240292000660	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
240292000661	replicative DNA helicase; Region: DnaB; TIGR00665
240292000662	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
240292000663	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
240292000664	Walker A motif; other site
240292000665	ATP binding site [chemical binding]; other site
240292000666	Walker B motif; other site
240292000667	DNA binding loops [nucleotide binding]
240292000668	ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554
240292000669	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
240292000670	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292000671	cofactor binding site; other site
240292000672	DNA binding site [nucleotide binding]
240292000673	substrate interaction site [chemical binding]; other site
240292000674	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
240292000675	Protein of unknown function, DUF488; Region: DUF488; cl01246
240292000676	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550
240292000677	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
240292000678	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
240292000679	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
240292000680	active site
240292000681	substrate binding site [chemical binding]; other site
240292000682	Mg2+ binding site [ion binding]; other site
240292000683	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
240292000684	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
240292000685	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
240292000686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
240292000687	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
240292000688	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
240292000689	nudix motif; other site
240292000690	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240292000691	Protein phosphatase 2C; Region: PP2C; pfam00481
240292000692	active site
240292000693	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292000694	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292000695	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292000696	phosphopeptide binding site; other site
240292000697	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240292000698	metal ion-dependent adhesion site (MIDAS); other site
240292000699	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240292000700	metal ion-dependent adhesion site (MIDAS); other site
240292000701	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
240292000702	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
240292000703	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240292000704	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240292000705	metal ion-dependent adhesion site (MIDAS); other site
240292000706	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
240292000707	ParB-like nuclease domain; Region: ParBc; pfam02195
240292000708	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292000709	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292000710	P-loop; other site
240292000711	Magnesium ion binding site [ion binding]; other site
240292000712	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292000713	Magnesium ion binding site [ion binding]; other site
240292000714	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
240292000715	catalytic nucleophile [active]
240292000716	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
240292000717	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
240292000718	catalytic residues [active]
240292000719	catalytic nucleophile [active]
240292000720	Presynaptic Site I dimer interface [polypeptide binding]; other site
240292000721	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
240292000722	Synaptic Flat tetramer interface [polypeptide binding]; other site
240292000723	Synaptic Site I dimer interface [polypeptide binding]; other site
240292000724	DNA binding site [nucleotide binding]
240292000725	Recombinase; Region: Recombinase; pfam07508
240292000726	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
240292000727	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
240292000728	MarR family; Region: MarR_2; pfam12802
240292000729	replicative DNA helicase; Region: DnaB; TIGR00665
240292000730	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
240292000731	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
240292000732	Walker A motif; other site
240292000733	ATP binding site [chemical binding]; other site
240292000734	Walker B motif; other site
240292000735	DNA binding loops [nucleotide binding]
240292000736	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
240292000737	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292000738	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292000739	active site
240292000740	catalytic residues [active]
240292000741	DNA binding site [nucleotide binding]
240292000742	Int/Topo IB signature motif; other site
240292000743	Zinc finger domain; Region: ZnF_RBZ; smart00547
240292000744	Double zinc ribbon; Region: DZR; pfam12773
240292000745	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292000746	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292000747	active site
240292000748	ATP binding site [chemical binding]; other site
240292000749	substrate binding site [chemical binding]; other site
240292000750	activation loop (A-loop); other site
240292000751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000752	binding surface
240292000753	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292000754	TPR motif; other site
240292000755	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240292000756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000757	TPR motif; other site
240292000758	binding surface
240292000759	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292000760	binding surface
240292000761	TPR motif; other site
240292000762	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292000763	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292000764	Condensation domain; Region: Condensation; pfam00668
240292000765	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292000766	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292000767	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000768	acyl-activating enzyme (AAE) consensus motif; other site
240292000769	AMP binding site [chemical binding]; other site
240292000770	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000771	Condensation domain; Region: Condensation; pfam00668
240292000772	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000773	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292000774	acyl-activating enzyme (AAE) consensus motif; other site
240292000775	AMP binding site [chemical binding]; other site
240292000776	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292000777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292000778	S-adenosylmethionine binding site [chemical binding]; other site
240292000779	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
240292000780	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000781	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
240292000782	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
240292000783	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000784	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000785	Condensation domain; Region: Condensation; pfam00668
240292000786	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292000787	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000788	acyl-activating enzyme (AAE) consensus motif; other site
240292000789	hypothetical protein; Provisional; Region: PRK08317
240292000790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292000791	S-adenosylmethionine binding site [chemical binding]; other site
240292000792	Condensation domain; Region: Condensation; pfam00668
240292000793	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292000794	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
240292000795	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000796	acyl-CoA synthetase; Validated; Region: PRK05850
240292000797	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
240292000798	acyl-activating enzyme (AAE) consensus motif; other site
240292000799	active site
240292000800	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000801	Condensation domain; Region: Condensation; pfam00668
240292000802	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292000803	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292000804	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000805	acyl-activating enzyme (AAE) consensus motif; other site
240292000806	AMP binding site [chemical binding]; other site
240292000807	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292000808	Condensation domain; Region: Condensation; pfam00668
240292000809	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292000810	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292000811	acyl-activating enzyme (AAE) consensus motif; other site
240292000812	AMP binding site [chemical binding]; other site
240292000813	AMIN domain; Region: AMIN; pfam11741
240292000814	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292000815	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292000816	N-terminal plug; other site
240292000817	ligand-binding site [chemical binding]; other site
240292000818	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
240292000819	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
240292000820	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
240292000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292000822	dimer interface [polypeptide binding]; other site
240292000823	conserved gate region; other site
240292000824	putative PBP binding loops; other site
240292000825	ABC-ATPase subunit interface; other site
240292000826	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
240292000827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292000828	dimer interface [polypeptide binding]; other site
240292000829	conserved gate region; other site
240292000830	putative PBP binding loops; other site
240292000831	ABC-ATPase subunit interface; other site
240292000832	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
240292000833	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292000834	Walker A/P-loop; other site
240292000835	ATP binding site [chemical binding]; other site
240292000836	Q-loop/lid; other site
240292000837	ABC transporter signature motif; other site
240292000838	Walker B; other site
240292000839	D-loop; other site
240292000840	H-loop/switch region; other site
240292000841	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240292000842	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292000843	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292000844	Walker A/P-loop; other site
240292000845	ATP binding site [chemical binding]; other site
240292000846	Q-loop/lid; other site
240292000847	ABC transporter signature motif; other site
240292000848	Walker B; other site
240292000849	D-loop; other site
240292000850	H-loop/switch region; other site
240292000851	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
240292000852	hypothetical protein; Region: PHA00684
240292000853	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000854	Probable transposase; Region: OrfB_IS605; pfam01385
240292000855	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000856	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
240292000857	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
240292000858	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
240292000859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292000860	putative substrate translocation pore; other site
240292000861	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
240292000862	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240292000863	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
240292000864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292000865	putative substrate translocation pore; other site
240292000866	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
240292000867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292000868	Predicted transcriptional regulator [Transcription]; Region: COG2345
240292000869	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
240292000870	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
240292000871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000872	Walker A motif; other site
240292000873	ATP binding site [chemical binding]; other site
240292000874	Walker B motif; other site
240292000875	arginine finger; other site
240292000876	Uncharacterized conserved protein [Function unknown]; Region: COG1430
240292000877	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
240292000878	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
240292000879	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
240292000880	putative active site [active]
240292000881	putative NTP binding site [chemical binding]; other site
240292000882	putative nucleic acid binding site [nucleotide binding]; other site
240292000883	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
240292000884	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292000885	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292000886	active site
240292000887	AAA-like domain; Region: AAA_10; pfam12846
240292000888	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
240292000889	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000890	Probable transposase; Region: OrfB_IS605; pfam01385
240292000891	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000892	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
240292000893	four helix bundle protein; Region: TIGR02436
240292000894	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
240292000895	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
240292000896	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
240292000897	protein-splicing catalytic site; other site
240292000898	thioester formation/cholesterol transfer; other site
240292000899	Pretoxin HINT domain; Region: PT-HINT; pfam07591
240292000900	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292000901	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292000902	CAAX protease self-immunity; Region: Abi; pfam02517
240292000903	CHAT domain; Region: CHAT; cl17868
240292000904	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
240292000905	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
240292000906	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240292000907	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
240292000908	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
240292000909	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
240292000910	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292000911	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292000912	active site
240292000913	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
240292000914	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292000915	ATP binding site [chemical binding]; other site
240292000916	putative Mg++ binding site [ion binding]; other site
240292000917	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292000918	nucleotide binding region [chemical binding]; other site
240292000919	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
240292000920	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
240292000921	polymerase nucleotide-binding site; other site
240292000922	DNA-binding residues [nucleotide binding]; DNA binding site
240292000923	nucleotide binding site [chemical binding]; other site
240292000924	primase nucleotide-binding site [nucleotide binding]; other site
240292000925	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
240292000926	Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460
240292000927	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
240292000928	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
240292000929	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
240292000930	ATP binding site [chemical binding]; other site
240292000931	substrate interface [chemical binding]; other site
240292000932	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
240292000933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292000934	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292000935	Probable transposase; Region: OrfB_IS605; pfam01385
240292000936	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292000937	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292000938	DNA polymerase III subunit beta; Validated; Region: PRK05643
240292000939	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
240292000940	putative DNA binding surface [nucleotide binding]; other site
240292000941	dimer interface [polypeptide binding]; other site
240292000942	beta-clamp/clamp loader binding surface; other site
240292000943	beta-clamp/translesion DNA polymerase binding surface; other site
240292000944	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
240292000945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292000946	Walker A motif; other site
240292000947	ATP binding site [chemical binding]; other site
240292000948	Walker B motif; other site
240292000949	arginine finger; other site
240292000950	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
240292000951	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
240292000952	active site
240292000953	catalytic site [active]
240292000954	substrate binding site [chemical binding]; other site
240292000955	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292000956	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292000957	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292000958	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
240292000959	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
240292000960	active site
240292000961	metal-binding site
240292000962	DNA polymerase III subunit delta; Validated; Region: PRK07452
240292000963	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
240292000964	DNA polymerase III subunit delta'; Validated; Region: PRK07399
240292000965	DNA polymerase III subunit delta'; Validated; Region: PRK08485
240292000966	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
240292000967	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292000968	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
240292000969	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240292000970	IHF dimer interface [polypeptide binding]; other site
240292000971	IHF - DNA interface [nucleotide binding]; other site
240292000972	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292000973	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
240292000974	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152
240292000975	homotrimer interaction site [polypeptide binding]; other site
240292000976	putative active site [active]
240292000977	CAAX protease self-immunity; Region: Abi; pfam02517
240292000978	CAAX protease self-immunity; Region: Abi; pfam02517
240292000979	CAAX protease self-immunity; Region: Abi; pfam02517
240292000980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292000981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292000982	choline dehydrogenase; Validated; Region: PRK02106
240292000983	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
240292000984	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292000985	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
240292000986	Isochorismatase family; Region: Isochorismatase; pfam00857
240292000987	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
240292000988	catalytic triad [active]
240292000989	dimer interface [polypeptide binding]; other site
240292000990	conserved cis-peptide bond; other site
240292000991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292000992	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
240292000993	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292000994	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292000995	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
240292000996	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240292000997	putative NAD(P) binding site [chemical binding]; other site
240292000998	short chain dehydrogenase; Provisional; Region: PRK06172
240292000999	classical (c) SDRs; Region: SDR_c; cd05233
240292001000	NAD(P) binding site [chemical binding]; other site
240292001001	active site
240292001002	SnoaL-like domain; Region: SnoaL_2; pfam12680
240292001003	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
240292001004	Thioredoxin; Region: Thioredoxin_4; cl17273
240292001005	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
240292001006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292001007	NAD(P) binding site [chemical binding]; other site
240292001008	active site
240292001009	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
240292001010	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
240292001011	NmrA-like family; Region: NmrA; pfam05368
240292001012	putative NADP binding site [chemical binding]; other site
240292001013	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
240292001014	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
240292001015	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292001016	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292001017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001018	active site
240292001019	phosphorylation site [posttranslational modification]
240292001020	intermolecular recognition site; other site
240292001021	dimerization interface [polypeptide binding]; other site
240292001022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292001023	DNA binding residues [nucleotide binding]
240292001024	dimerization interface [polypeptide binding]; other site
240292001025	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292001026	active site
240292001027	ATP binding site [chemical binding]; other site
240292001028	substrate binding site [chemical binding]; other site
240292001029	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
240292001030	activation loop (A-loop); other site
240292001031	AAA ATPase domain; Region: AAA_16; pfam13191
240292001032	Predicted ATPase [General function prediction only]; Region: COG3899
240292001033	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292001034	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001035	PAS fold; Region: PAS_4; pfam08448
240292001036	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
240292001037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001038	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292001039	putative active site [active]
240292001040	heme pocket [chemical binding]; other site
240292001041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001042	putative active site [active]
240292001043	heme pocket [chemical binding]; other site
240292001044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001045	PAS fold; Region: PAS_3; pfam08447
240292001046	putative active site [active]
240292001047	heme pocket [chemical binding]; other site
240292001048	PAS fold; Region: PAS_4; pfam08448
240292001049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001050	putative active site [active]
240292001051	heme pocket [chemical binding]; other site
240292001052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292001053	Histidine kinase; Region: HisKA_3; pfam07730
240292001054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001055	ATP binding site [chemical binding]; other site
240292001056	Mg2+ binding site [ion binding]; other site
240292001057	G-X-G motif; other site
240292001058	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240292001059	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240292001060	dimer interface [polypeptide binding]; other site
240292001061	ssDNA binding site [nucleotide binding]; other site
240292001062	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240292001063	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292001064	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292001065	P-loop; other site
240292001066	Magnesium ion binding site [ion binding]; other site
240292001067	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292001068	Magnesium ion binding site [ion binding]; other site
240292001069	RRXRR protein; Region: RRXRR; pfam14239
240292001070	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292001071	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292001072	active site
240292001073	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
240292001074	ParB-like nuclease domain; Region: ParB; smart00470
240292001075	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
240292001076	Ligand binding site; other site
240292001077	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
240292001078	metal-binding site
240292001079	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
240292001080	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
240292001081	XdhC Rossmann domain; Region: XdhC_C; pfam13478
240292001082	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
240292001083	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
240292001084	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
240292001085	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
240292001086	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
240292001087	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
240292001088	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292001089	catalytic loop [active]
240292001090	iron binding site [ion binding]; other site
240292001091	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
240292001092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
240292001093	Heat induced stress protein YflT; Region: YflT; pfam11181
240292001094	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
240292001095	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
240292001096	Clp amino terminal domain; Region: Clp_N; pfam02861
240292001097	Clp amino terminal domain; Region: Clp_N; pfam02861
240292001098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001099	Walker A motif; other site
240292001100	ATP binding site [chemical binding]; other site
240292001101	Walker B motif; other site
240292001102	arginine finger; other site
240292001103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001104	Walker A motif; other site
240292001105	ATP binding site [chemical binding]; other site
240292001106	Walker B motif; other site
240292001107	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240292001108	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
240292001109	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
240292001110	chaperone protein DnaJ; Provisional; Region: PRK14299
240292001111	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292001112	HSP70 interaction site [polypeptide binding]; other site
240292001113	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240292001114	substrate binding site [polypeptide binding]; other site
240292001115	dimer interface [polypeptide binding]; other site
240292001116	YfdX protein; Region: YfdX; pfam10938
240292001117	YfdX protein; Region: YfdX; pfam10938
240292001118	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292001119	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292001120	active site
240292001121	catalytic tetrad [active]
240292001122	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
240292001123	BON domain; Region: BON; pfam04972
240292001124	BON domain; Region: BON; cl02771
240292001125	BON domain; Region: BON; pfam04972
240292001126	ChaB; Region: ChaB; cl01887
240292001127	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
240292001128	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
240292001129	nucleotide binding site [chemical binding]; other site
240292001130	NEF interaction site [polypeptide binding]; other site
240292001131	SBD interface [polypeptide binding]; other site
240292001132	Thioredoxin; Region: Thioredoxin_4; pfam13462
240292001133	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
240292001134	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
240292001135	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
240292001136	putative dimer interface [polypeptide binding]; other site
240292001137	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
240292001138	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
240292001139	ring oligomerisation interface [polypeptide binding]; other site
240292001140	ATP/Mg binding site [chemical binding]; other site
240292001141	stacking interactions; other site
240292001142	hinge regions; other site
240292001143	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
240292001144	oligomerisation interface [polypeptide binding]; other site
240292001145	mobile loop; other site
240292001146	roof hairpin; other site
240292001147	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
240292001148	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
240292001149	active site
240292001150	FMN binding site [chemical binding]; other site
240292001151	substrate binding site [chemical binding]; other site
240292001152	homotetramer interface [polypeptide binding]; other site
240292001153	catalytic residue [active]
240292001154	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
240292001155	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
240292001156	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
240292001157	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
240292001158	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
240292001159	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
240292001160	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001161	GAF domain; Region: GAF_2; pfam13185
240292001162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001163	PAS fold; Region: PAS_3; pfam08447
240292001164	putative active site [active]
240292001165	heme pocket [chemical binding]; other site
240292001166	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292001167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001168	dimer interface [polypeptide binding]; other site
240292001169	phosphorylation site [posttranslational modification]
240292001170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001171	ATP binding site [chemical binding]; other site
240292001172	Mg2+ binding site [ion binding]; other site
240292001173	G-X-G motif; other site
240292001174	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001176	active site
240292001177	phosphorylation site [posttranslational modification]
240292001178	intermolecular recognition site; other site
240292001179	dimerization interface [polypeptide binding]; other site
240292001180	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292001181	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292001182	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
240292001183	putative ADP-binding pocket [chemical binding]; other site
240292001184	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001186	active site
240292001187	phosphorylation site [posttranslational modification]
240292001188	intermolecular recognition site; other site
240292001189	dimerization interface [polypeptide binding]; other site
240292001190	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292001191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001192	active site
240292001193	phosphorylation site [posttranslational modification]
240292001194	intermolecular recognition site; other site
240292001195	dimerization interface [polypeptide binding]; other site
240292001196	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292001197	DNA binding site [nucleotide binding]
240292001198	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292001199	putative binding surface; other site
240292001200	active site
240292001201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001202	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001203	active site
240292001204	phosphorylation site [posttranslational modification]
240292001205	intermolecular recognition site; other site
240292001206	dimerization interface [polypeptide binding]; other site
240292001207	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001209	active site
240292001210	phosphorylation site [posttranslational modification]
240292001211	intermolecular recognition site; other site
240292001212	dimerization interface [polypeptide binding]; other site
240292001213	flavodoxin FldA; Validated; Region: PRK09267
240292001214	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
240292001215	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292001216	NAD binding site [chemical binding]; other site
240292001217	catalytic Zn binding site [ion binding]; other site
240292001218	structural Zn binding site [ion binding]; other site
240292001219	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240292001220	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292001221	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240292001222	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
240292001223	putative hydrophobic ligand binding site [chemical binding]; other site
240292001224	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292001225	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292001226	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
240292001227	DDE superfamily endonuclease; Region: DDE_4; cl17710
240292001228	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
240292001229	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
240292001230	Mg binding site [ion binding]; other site
240292001231	nucleotide binding site [chemical binding]; other site
240292001232	putative protofilament interface [polypeptide binding]; other site
240292001233	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
240292001234	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
240292001235	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292001236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001237	AAA domain; Region: AAA_22; pfam13401
240292001238	Walker A motif; other site
240292001239	ATP binding site [chemical binding]; other site
240292001240	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292001241	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292001242	Integrase core domain; Region: rve; pfam00665
240292001243	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292001244	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292001245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001246	active site
240292001247	phosphorylation site [posttranslational modification]
240292001248	intermolecular recognition site; other site
240292001249	dimerization interface [polypeptide binding]; other site
240292001250	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292001251	DNA binding residues [nucleotide binding]
240292001252	dimerization interface [polypeptide binding]; other site
240292001253	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292001254	Homeodomain-like domain; Region: HTH_23; pfam13384
240292001255	Winged helix-turn helix; Region: HTH_29; pfam13551
240292001256	orc1/cdc6 family replication initiation protein; Region: TIGR02928
240292001257	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
240292001258	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
240292001259	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
240292001260	N-acetyl-D-glucosamine binding site [chemical binding]; other site
240292001261	catalytic residue [active]
240292001262	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292001263	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292001264	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
240292001265	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292001266	nucleotide binding region [chemical binding]; other site
240292001267	ATP-binding site [chemical binding]; other site
240292001268	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292001269	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292001270	AAA domain; Region: AAA_21; pfam13304
240292001271	Walker A/P-loop; other site
240292001272	ATP binding site [chemical binding]; other site
240292001273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292001274	Q-loop/lid; other site
240292001275	ABC transporter signature motif; other site
240292001276	Walker B; other site
240292001277	D-loop; other site
240292001278	H-loop/switch region; other site
240292001279	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292001280	nucleotide binding region [chemical binding]; other site
240292001281	ATP-binding site [chemical binding]; other site
240292001282	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
240292001283	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
240292001284	PLD-like domain; Region: PLDc_2; pfam13091
240292001285	putative active site [active]
240292001286	putative catalytic site [active]
240292001287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292001288	non-specific DNA binding site [nucleotide binding]; other site
240292001289	salt bridge; other site
240292001290	sequence-specific DNA binding site [nucleotide binding]; other site
240292001291	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
240292001292	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292001293	cofactor binding site; other site
240292001294	DNA binding site [nucleotide binding]
240292001295	substrate interaction site [chemical binding]; other site
240292001296	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292001297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292001298	ATP binding site [chemical binding]; other site
240292001299	putative Mg++ binding site [ion binding]; other site
240292001300	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
240292001301	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292001302	ATP-binding site [chemical binding]; other site
240292001303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001304	AAA domain; Region: AAA_22; pfam13401
240292001305	Walker A motif; other site
240292001306	ATP binding site [chemical binding]; other site
240292001307	Walker B motif; other site
240292001308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292001309	nucleotide binding region [chemical binding]; other site
240292001310	ATP-binding site [chemical binding]; other site
240292001311	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
240292001312	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
240292001313	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
240292001314	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292001315	active site
240292001316	catalytic residues [active]
240292001317	DNA binding site [nucleotide binding]
240292001318	Int/Topo IB signature motif; other site
240292001319	AAA domain; Region: AAA_22; pfam13401
240292001320	Integrase core domain; Region: rve; pfam00665
240292001321	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292001322	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
240292001323	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
240292001324	DnaA N-terminal domain; Region: DnaA_N; pfam11638
240292001325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001326	Walker A motif; other site
240292001327	ATP binding site [chemical binding]; other site
240292001328	Walker B motif; other site
240292001329	arginine finger; other site
240292001330	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
240292001331	DnaA box-binding interface [nucleotide binding]; other site
240292001332	DNA polymerase III subunit beta; Validated; Region: PRK05643
240292001333	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
240292001334	putative DNA binding surface [nucleotide binding]; other site
240292001335	dimer interface [polypeptide binding]; other site
240292001336	beta-clamp/clamp loader binding surface; other site
240292001337	beta-clamp/translesion DNA polymerase binding surface; other site
240292001338	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
240292001339	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
240292001340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292001341	dimer interface [polypeptide binding]; other site
240292001342	conserved gate region; other site
240292001343	putative PBP binding loops; other site
240292001344	ABC-ATPase subunit interface; other site
240292001345	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
240292001346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292001347	putative PBP binding loops; other site
240292001348	dimer interface [polypeptide binding]; other site
240292001349	ABC-ATPase subunit interface; other site
240292001350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292001351	S-adenosylmethionine binding site [chemical binding]; other site
240292001352	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
240292001353	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
240292001354	nudix motif; other site
240292001355	Predicted transcriptional regulators [Transcription]; Region: COG1695
240292001356	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
240292001357	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
240292001358	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292001359	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292001360	active site
240292001361	ATP binding site [chemical binding]; other site
240292001362	substrate binding site [chemical binding]; other site
240292001363	activation loop (A-loop); other site
240292001364	hydrolase, alpha/beta fold family protein; Region: PLN02824
240292001365	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292001366	Protein of function (DUF2518); Region: DUF2518; pfam10726
240292001367	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
240292001368	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
240292001369	putative active site [active]
240292001370	metal binding site [ion binding]; metal-binding site
240292001371	aspartate aminotransferase; Provisional; Region: PRK05942
240292001372	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292001373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292001374	homodimer interface [polypeptide binding]; other site
240292001375	catalytic residue [active]
240292001376	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292001377	dimerization interface [polypeptide binding]; other site
240292001378	putative DNA binding site [nucleotide binding]; other site
240292001379	putative Zn2+ binding site [ion binding]; other site
240292001380	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292001381	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292001382	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292001383	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292001384	TPR repeat; Region: TPR_11; pfam13414
240292001385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292001386	binding surface
240292001387	TPR motif; other site
240292001388	Putative transcription activator [Transcription]; Region: TenA; COG0819
240292001389	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
240292001390	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
240292001391	Ligand binding site; other site
240292001392	Putative Catalytic site; other site
240292001393	DXD motif; other site
240292001394	Predicted membrane protein [Function unknown]; Region: COG2246
240292001395	GtrA-like protein; Region: GtrA; pfam04138
240292001396	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
240292001397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292001398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001399	dimer interface [polypeptide binding]; other site
240292001400	phosphorylation site [posttranslational modification]
240292001401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001402	ATP binding site [chemical binding]; other site
240292001403	Mg2+ binding site [ion binding]; other site
240292001404	G-X-G motif; other site
240292001405	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
240292001406	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292001407	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292001408	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292001409	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
240292001410	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
240292001411	active site
240292001412	interdomain interaction site; other site
240292001413	putative metal-binding site [ion binding]; other site
240292001414	nucleotide binding site [chemical binding]; other site
240292001415	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
240292001416	domain I; other site
240292001417	phosphate binding site [ion binding]; other site
240292001418	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
240292001419	domain II; other site
240292001420	domain III; other site
240292001421	nucleotide binding site [chemical binding]; other site
240292001422	DNA binding groove [nucleotide binding]
240292001423	catalytic site [active]
240292001424	domain IV; other site
240292001425	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
240292001426	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
240292001427	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
240292001428	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
240292001429	Dehydroquinase class II; Region: DHquinase_II; pfam01220
240292001430	trimer interface [polypeptide binding]; other site
240292001431	active site
240292001432	dimer interface [polypeptide binding]; other site
240292001433	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
240292001434	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
240292001435	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
240292001436	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240292001437	Zn2+ binding site [ion binding]; other site
240292001438	Mg2+ binding site [ion binding]; other site
240292001439	Uncharacterized conserved protein [Function unknown]; Region: COG3349
240292001440	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292001441	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
240292001442	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
240292001443	iron-sulfur cluster [ion binding]; other site
240292001444	[2Fe-2S] cluster binding site [ion binding]; other site
240292001445	Uncharacterized conserved protein [Function unknown]; Region: COG3349
240292001446	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
240292001447	Caspase domain; Region: Peptidase_C14; pfam00656
240292001448	AAA ATPase domain; Region: AAA_16; pfam13191
240292001449	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292001450	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292001451	structural tetrad; other site
240292001452	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292001453	structural tetrad; other site
240292001454	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
240292001455	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292001456	FeS/SAM binding site; other site
240292001457	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
240292001458	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292001459	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292001460	PBP superfamily domain; Region: PBP_like_2; cl17296
240292001461	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
240292001462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292001463	dimer interface [polypeptide binding]; other site
240292001464	conserved gate region; other site
240292001465	putative PBP binding loops; other site
240292001466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
240292001467	ABC-ATPase subunit interface; other site
240292001468	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
240292001469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292001470	dimer interface [polypeptide binding]; other site
240292001471	conserved gate region; other site
240292001472	putative PBP binding loops; other site
240292001473	ABC-ATPase subunit interface; other site
240292001474	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265
240292001475	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240292001476	Walker A/P-loop; other site
240292001477	ATP binding site [chemical binding]; other site
240292001478	Q-loop/lid; other site
240292001479	ABC transporter signature motif; other site
240292001480	Walker B; other site
240292001481	D-loop; other site
240292001482	H-loop/switch region; other site
240292001483	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292001484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001485	Walker A motif; other site
240292001486	ATP binding site [chemical binding]; other site
240292001487	Walker B motif; other site
240292001488	HEAT repeats; Region: HEAT_2; pfam13646
240292001489	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292001490	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292001491	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292001492	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292001493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292001494	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292001495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001496	putative active site [active]
240292001497	heme pocket [chemical binding]; other site
240292001498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001499	putative active site [active]
240292001500	heme pocket [chemical binding]; other site
240292001501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292001502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001503	dimer interface [polypeptide binding]; other site
240292001504	phosphorylation site [posttranslational modification]
240292001505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001506	ATP binding site [chemical binding]; other site
240292001507	Mg2+ binding site [ion binding]; other site
240292001508	G-X-G motif; other site
240292001509	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292001510	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292001511	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292001512	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
240292001513	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
240292001514	putative catalytic cysteine [active]
240292001515	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001517	active site
240292001518	phosphorylation site [posttranslational modification]
240292001519	intermolecular recognition site; other site
240292001520	dimerization interface [polypeptide binding]; other site
240292001521	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001523	active site
240292001524	phosphorylation site [posttranslational modification]
240292001525	intermolecular recognition site; other site
240292001526	dimerization interface [polypeptide binding]; other site
240292001527	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
240292001528	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292001529	dimerization interface [polypeptide binding]; other site
240292001530	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
240292001531	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
240292001532	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
240292001533	dimer interface [polypeptide binding]; other site
240292001534	putative CheW interface [polypeptide binding]; other site
240292001535	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
240292001536	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292001537	putative binding surface; other site
240292001538	active site
240292001539	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
240292001540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001541	ATP binding site [chemical binding]; other site
240292001542	Mg2+ binding site [ion binding]; other site
240292001543	G-X-G motif; other site
240292001544	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
240292001545	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292001546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001547	active site
240292001548	phosphorylation site [posttranslational modification]
240292001549	intermolecular recognition site; other site
240292001550	dimerization interface [polypeptide binding]; other site
240292001551	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
240292001552	active site
240292001553	substrate binding site [chemical binding]; other site
240292001554	ATP binding site [chemical binding]; other site
240292001555	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001557	active site
240292001558	phosphorylation site [posttranslational modification]
240292001559	intermolecular recognition site; other site
240292001560	dimerization interface [polypeptide binding]; other site
240292001561	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292001562	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001563	PAS domain S-box; Region: sensory_box; TIGR00229
240292001564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001565	putative active site [active]
240292001566	heme pocket [chemical binding]; other site
240292001567	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001568	PAS fold; Region: PAS_3; pfam08447
240292001569	putative active site [active]
240292001570	heme pocket [chemical binding]; other site
240292001571	PAS domain S-box; Region: sensory_box; TIGR00229
240292001572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001573	putative active site [active]
240292001574	heme pocket [chemical binding]; other site
240292001575	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001576	PAS fold; Region: PAS_3; pfam08447
240292001577	putative active site [active]
240292001578	heme pocket [chemical binding]; other site
240292001579	PAS domain S-box; Region: sensory_box; TIGR00229
240292001580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001581	putative active site [active]
240292001582	heme pocket [chemical binding]; other site
240292001583	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001584	PAS fold; Region: PAS_3; pfam08447
240292001585	putative active site [active]
240292001586	heme pocket [chemical binding]; other site
240292001587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001588	PAS fold; Region: PAS_3; pfam08447
240292001589	putative active site [active]
240292001590	heme pocket [chemical binding]; other site
240292001591	PAS domain S-box; Region: sensory_box; TIGR00229
240292001592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001593	putative active site [active]
240292001594	heme pocket [chemical binding]; other site
240292001595	PAS domain; Region: PAS_9; pfam13426
240292001596	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292001597	Histidine kinase; Region: HisKA_2; pfam07568
240292001598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001599	ATP binding site [chemical binding]; other site
240292001600	Mg2+ binding site [ion binding]; other site
240292001601	G-X-G motif; other site
240292001602	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001604	active site
240292001605	phosphorylation site [posttranslational modification]
240292001606	intermolecular recognition site; other site
240292001607	dimerization interface [polypeptide binding]; other site
240292001608	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292001609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001610	active site
240292001611	phosphorylation site [posttranslational modification]
240292001612	intermolecular recognition site; other site
240292001613	dimerization interface [polypeptide binding]; other site
240292001614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292001615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001616	dimer interface [polypeptide binding]; other site
240292001617	phosphorylation site [posttranslational modification]
240292001618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001619	ATP binding site [chemical binding]; other site
240292001620	G-X-G motif; other site
240292001621	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292001622	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292001623	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
240292001624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001625	Walker A motif; other site
240292001626	ATP binding site [chemical binding]; other site
240292001627	Walker B motif; other site
240292001628	arginine finger; other site
240292001629	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240292001630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001631	Walker A motif; other site
240292001632	ATP binding site [chemical binding]; other site
240292001633	Walker B motif; other site
240292001634	arginine finger; other site
240292001635	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
240292001636	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292001637	P loop; other site
240292001638	Nucleotide binding site [chemical binding]; other site
240292001639	DTAP/Switch II; other site
240292001640	Switch I; other site
240292001641	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
240292001642	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292001643	DTAP/Switch II; other site
240292001644	Switch I; other site
240292001645	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
240292001646	Gas vesicle protein G; Region: GvpG; pfam05120
240292001647	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
240292001648	Gas vesicle protein K; Region: GvpK; pfam05121
240292001649	Gas vesicle protein; Region: Gas_vesicle; pfam00741
240292001650	Gas vesicle protein; Region: Gas_vesicle; pfam00741
240292001651	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
240292001652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001653	Walker A motif; other site
240292001654	ATP binding site [chemical binding]; other site
240292001655	Walker B motif; other site
240292001656	arginine finger; other site
240292001657	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
240292001658	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
240292001659	Inositol polyphosphate kinase; Region: IPK; cl12283
240292001660	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292001661	Uncharacterized conserved protein [Function unknown]; Region: COG3349
240292001662	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292001663	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292001664	active site
240292001665	ATP binding site [chemical binding]; other site
240292001666	substrate binding site [chemical binding]; other site
240292001667	activation loop (A-loop); other site
240292001668	AAA ATPase domain; Region: AAA_16; pfam13191
240292001669	Predicted ATPase [General function prediction only]; Region: COG3899
240292001670	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292001671	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001673	dimer interface [polypeptide binding]; other site
240292001674	phosphorylation site [posttranslational modification]
240292001675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001676	ATP binding site [chemical binding]; other site
240292001677	Mg2+ binding site [ion binding]; other site
240292001678	G-X-G motif; other site
240292001679	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292001680	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292001681	active site
240292001682	ATP binding site [chemical binding]; other site
240292001683	substrate binding site [chemical binding]; other site
240292001684	activation loop (A-loop); other site
240292001685	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
240292001686	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292001687	dimerization interface [polypeptide binding]; other site
240292001688	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
240292001689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
240292001690	membrane-bound complex binding site; other site
240292001691	heat shock protein HtpX; Provisional; Region: PRK03982
240292001692	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
240292001693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292001694	Ligand Binding Site [chemical binding]; other site
240292001695	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292001696	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
240292001697	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001698	GAF domain; Region: GAF_2; pfam13185
240292001699	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292001700	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292001701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292001702	putative active site [active]
240292001703	heme pocket [chemical binding]; other site
240292001704	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240292001705	cyclase homology domain; Region: CHD; cd07302
240292001706	nucleotidyl binding site; other site
240292001707	metal binding site [ion binding]; metal-binding site
240292001708	dimer interface [polypeptide binding]; other site
240292001709	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
240292001710	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
240292001711	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
240292001712	ATP binding site [chemical binding]; other site
240292001713	active site
240292001714	substrate binding site [chemical binding]; other site
240292001715	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240292001716	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
240292001717	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240292001718	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292001719	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
240292001720	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
240292001721	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
240292001722	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
240292001723	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
240292001724	active site
240292001725	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
240292001726	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
240292001727	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
240292001728	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292001729	putative active site [active]
240292001730	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
240292001731	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292001732	cofactor binding site; other site
240292001733	DNA binding site [nucleotide binding]
240292001734	substrate interaction site [chemical binding]; other site
240292001735	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292001736	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
240292001737	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292001738	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
240292001739	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
240292001740	active site
240292001741	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
240292001742	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
240292001743	active site
240292001744	non-prolyl cis peptide bond; other site
240292001745	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
240292001746	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
240292001747	active site
240292001748	dimer interface [polypeptide binding]; other site
240292001749	non-prolyl cis peptide bond; other site
240292001750	insertion regions; other site
240292001751	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
240292001752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292001753	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292001754	putative substrate translocation pore; other site
240292001755	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292001756	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292001757	active site
240292001758	catalytic tetrad [active]
240292001759	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
240292001760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292001761	active site
240292001762	motif I; other site
240292001763	motif II; other site
240292001764	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
240292001765	Sodium Bile acid symporter family; Region: SBF; cl17470
240292001766	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
240292001767	Sulfatase; Region: Sulfatase; pfam00884
240292001768	Uncharacterized conserved protein [Function unknown]; Region: COG1262
240292001769	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240292001770	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
240292001771	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292001772	motif II; other site
240292001773	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
240292001774	active site
240292001775	putative DNA-binding cleft [nucleotide binding]; other site
240292001776	dimer interface [polypeptide binding]; other site
240292001777	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
240292001778	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
240292001779	phosphate binding site [ion binding]; other site
240292001780	putative substrate binding pocket [chemical binding]; other site
240292001781	dimer interface [polypeptide binding]; other site
240292001782	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
240292001783	Patatin [General function prediction only]; Region: COG3621
240292001784	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
240292001785	active site
240292001786	nucleophile elbow; other site
240292001787	dihydroorotase; Provisional; Region: PRK07575
240292001788	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240292001789	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
240292001790	active site
240292001791	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
240292001792	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240292001793	Catalytic site [active]
240292001794	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240292001795	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
240292001796	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
240292001797	MOSC domain; Region: MOSC; pfam03473
240292001798	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001800	active site
240292001801	phosphorylation site [posttranslational modification]
240292001802	intermolecular recognition site; other site
240292001803	dimerization interface [polypeptide binding]; other site
240292001804	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292001805	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292001806	metal binding site [ion binding]; metal-binding site
240292001807	active site
240292001808	I-site; other site
240292001809	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292001810	Response regulator receiver domain; Region: Response_reg; pfam00072
240292001811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292001812	active site
240292001813	phosphorylation site [posttranslational modification]
240292001814	intermolecular recognition site; other site
240292001815	dimerization interface [polypeptide binding]; other site
240292001816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292001817	dimer interface [polypeptide binding]; other site
240292001818	phosphorylation site [posttranslational modification]
240292001819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001820	ATP binding site [chemical binding]; other site
240292001821	G-X-G motif; other site
240292001822	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
240292001823	4Fe-4S binding domain; Region: Fer4; pfam00037
240292001824	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
240292001825	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
240292001826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001827	Walker A motif; other site
240292001828	ATP binding site [chemical binding]; other site
240292001829	Walker B motif; other site
240292001830	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
240292001831	RxxxH motif; other site
240292001832	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
240292001833	putative active site [active]
240292001834	Mn binding site [ion binding]; other site
240292001835	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292001836	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292001837	Homeodomain-like domain; Region: HTH_23; pfam13384
240292001838	Winged helix-turn helix; Region: HTH_29; pfam13551
240292001839	Winged helix-turn helix; Region: HTH_33; pfam13592
240292001840	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292001841	Peptidase family M48; Region: Peptidase_M48; pfam01435
240292001842	Circadian oscillating protein COP23; Region: COP23; pfam14218
240292001843	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
240292001844	ketol-acid reductoisomerase; Provisional; Region: PRK05479
240292001845	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
240292001846	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
240292001847	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292001848	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292001849	active site
240292001850	catalytic tetrad [active]
240292001851	Staphylococcal nuclease homologues; Region: SNc; smart00318
240292001852	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
240292001853	Catalytic site; other site
240292001854	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
240292001855	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
240292001856	Nitrogen regulatory protein P-II; Region: P-II; smart00938
240292001857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292001858	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
240292001859	dimer interface [polypeptide binding]; other site
240292001860	active site
240292001861	metal binding site [ion binding]; metal-binding site
240292001862	glutathione binding site [chemical binding]; other site
240292001863	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
240292001864	Clp amino terminal domain; Region: Clp_N; pfam02861
240292001865	Clp amino terminal domain; Region: Clp_N; pfam02861
240292001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001867	Walker A motif; other site
240292001868	ATP binding site [chemical binding]; other site
240292001869	Walker B motif; other site
240292001870	arginine finger; other site
240292001871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292001872	Walker A motif; other site
240292001873	ATP binding site [chemical binding]; other site
240292001874	Walker B motif; other site
240292001875	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240292001876	heat shock protein 90; Provisional; Region: PRK05218
240292001877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292001878	ATP binding site [chemical binding]; other site
240292001879	Mg2+ binding site [ion binding]; other site
240292001880	G-X-G motif; other site
240292001881	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
240292001882	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292001883	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292001884	ligand binding site [chemical binding]; other site
240292001885	flexible hinge region; other site
240292001886	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
240292001887	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
240292001888	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
240292001889	protein binding site [polypeptide binding]; other site
240292001890	allophycocyanin, beta subunit; Region: apcB; TIGR01337
240292001891	glutamine synthetase, type I; Region: GlnA; TIGR00653
240292001892	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
240292001893	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
240292001894	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292001895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292001896	S-adenosylmethionine binding site [chemical binding]; other site
240292001897	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
240292001898	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
240292001899	putative substrate binding region [chemical binding]; other site
240292001900	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292001901	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292001902	active site
240292001903	ATP binding site [chemical binding]; other site
240292001904	substrate binding site [chemical binding]; other site
240292001905	activation loop (A-loop); other site
240292001906	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292001907	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
240292001908	putative NAD(P) binding site [chemical binding]; other site
240292001909	catalytic Zn binding site [ion binding]; other site
240292001910	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
240292001911	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
240292001912	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
240292001913	linker region; other site
240292001914	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
240292001915	EamA-like transporter family; Region: EamA; pfam00892
240292001916	EamA-like transporter family; Region: EamA; pfam00892
240292001917	heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245
240292001918	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
240292001919	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292001920	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292001921	homodimer interface [polypeptide binding]; other site
240292001922	catalytic residue [active]
240292001923	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292001924	catalytic residues [active]
240292001925	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
240292001926	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
240292001927	Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives [General function prediction only]; Region: COG5512
240292001928	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
240292001929	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
240292001930	substrate binding site [chemical binding]; other site
240292001931	oxyanion hole (OAH) forming residues; other site
240292001932	trimer interface [polypeptide binding]; other site
240292001933	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292001934	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292001935	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292001936	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292001937	phosphoribulokinase; Provisional; Region: PRK07429
240292001938	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
240292001939	active site
240292001940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292001941	FeS/SAM binding site; other site
240292001942	hypothetical protein; Reviewed; Region: PRK00024
240292001943	Helix-hairpin-helix motif; Region: HHH; pfam00633
240292001944	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
240292001945	MPN+ (JAMM) motif; other site
240292001946	Zinc-binding site [ion binding]; other site
240292001947	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292001948	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292001949	structural tetrad; other site
240292001950	light-harvesting-like protein 3; Provisional; Region: PLN00014
240292001951	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
240292001952	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
240292001953	hexamer interface [polypeptide binding]; other site
240292001954	ligand binding site [chemical binding]; other site
240292001955	putative active site [active]
240292001956	NAD(P) binding site [chemical binding]; other site
240292001957	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
240292001958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
240292001959	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
240292001960	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
240292001961	Walker A/P-loop; other site
240292001962	ATP binding site [chemical binding]; other site
240292001963	Q-loop/lid; other site
240292001964	ABC transporter signature motif; other site
240292001965	Walker B; other site
240292001966	D-loop; other site
240292001967	H-loop/switch region; other site
240292001968	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
240292001969	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
240292001970	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
240292001971	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
240292001972	active site
240292001973	Substrate binding site; other site
240292001974	Mg++ binding site; other site
240292001975	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
240292001976	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
240292001977	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
240292001978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
240292001979	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292001980	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292001981	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
240292001982	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
240292001983	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
240292001984	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292001985	catalytic residues [active]
240292001986	translation initiation factor IF-3; Region: infC; TIGR00168
240292001987	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
240292001988	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
240292001989	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292001990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292001991	Walker A/P-loop; other site
240292001992	ATP binding site [chemical binding]; other site
240292001993	Q-loop/lid; other site
240292001994	ABC transporter signature motif; other site
240292001995	Walker B; other site
240292001996	D-loop; other site
240292001997	H-loop/switch region; other site
240292001998	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
240292001999	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240292002000	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240292002001	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240292002002	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292002003	catalytic triad [active]
240292002004	cobyric acid synthase; Provisional; Region: PRK00784
240292002005	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
240292002006	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
240292002007	catalytic triad [active]
240292002008	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292002009	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292002010	catalytic loop [active]
240292002011	iron binding site [ion binding]; other site
240292002012	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292002013	FOG: CBS domain [General function prediction only]; Region: COG0517
240292002014	FOG: CBS domain [General function prediction only]; Region: COG0517
240292002015	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
240292002016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002017	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292002018	putative active site [active]
240292002019	heme pocket [chemical binding]; other site
240292002020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002021	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292002022	putative active site [active]
240292002023	heme pocket [chemical binding]; other site
240292002024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002025	putative active site [active]
240292002026	heme pocket [chemical binding]; other site
240292002027	PAS fold; Region: PAS_4; pfam08448
240292002028	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240292002029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002030	putative active site [active]
240292002031	heme pocket [chemical binding]; other site
240292002032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002033	dimer interface [polypeptide binding]; other site
240292002034	phosphorylation site [posttranslational modification]
240292002035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002036	ATP binding site [chemical binding]; other site
240292002037	Mg2+ binding site [ion binding]; other site
240292002038	G-X-G motif; other site
240292002039	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002041	active site
240292002042	phosphorylation site [posttranslational modification]
240292002043	intermolecular recognition site; other site
240292002044	dimerization interface [polypeptide binding]; other site
240292002045	Predicted integral membrane protein [Function unknown]; Region: COG5637
240292002046	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
240292002047	putative hydrophobic ligand binding site [chemical binding]; other site
240292002048	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
240292002049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292002050	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
240292002051	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
240292002052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002053	binding surface
240292002054	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292002055	TPR motif; other site
240292002056	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
240292002057	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
240292002058	putative NAD(P) binding site [chemical binding]; other site
240292002059	putative active site [active]
240292002060	hypothetical protein; Validated; Region: PRK07413
240292002061	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
240292002062	Walker A motif; other site
240292002063	homodimer interface [polypeptide binding]; other site
240292002064	ATP binding site [chemical binding]; other site
240292002065	hydroxycobalamin binding site [chemical binding]; other site
240292002066	Walker B motif; other site
240292002067	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
240292002068	homodimer interface [polypeptide binding]; other site
240292002069	Walker A motif; other site
240292002070	ATP binding site [chemical binding]; other site
240292002071	hydroxycobalamin binding site [chemical binding]; other site
240292002072	Walker B motif; other site
240292002073	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
240292002074	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292002075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002077	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292002078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002079	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002080	MltA specific insert domain; Region: MltA; cl08398
240292002081	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
240292002082	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292002083	inhibitor-cofactor binding pocket; inhibition site
240292002084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292002085	catalytic residue [active]
240292002086	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292002087	putative active site [active]
240292002088	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
240292002089	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
240292002090	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
240292002091	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
240292002092	acyl-activating enzyme (AAE) consensus motif; other site
240292002093	active site
240292002094	AMP binding site [chemical binding]; other site
240292002095	CoA binding site [chemical binding]; other site
240292002096	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292002097	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292002098	active site
240292002099	ATP binding site [chemical binding]; other site
240292002100	substrate binding site [chemical binding]; other site
240292002101	activation loop (A-loop); other site
240292002102	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
240292002103	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292002104	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292002105	active site
240292002106	ATP binding site [chemical binding]; other site
240292002107	substrate binding site [chemical binding]; other site
240292002108	activation loop (A-loop); other site
240292002109	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
240292002110	Peptidase family M41; Region: Peptidase_M41; pfam01434
240292002111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292002112	metal binding site [ion binding]; metal-binding site
240292002113	active site
240292002114	I-site; other site
240292002115	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
240292002116	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
240292002117	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
240292002118	motif 1; other site
240292002119	active site
240292002120	motif 2; other site
240292002121	motif 3; other site
240292002122	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
240292002123	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292002124	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292002125	active site
240292002126	AAA ATPase domain; Region: AAA_16; pfam13191
240292002127	Walker A motif; other site
240292002128	ATP binding site [chemical binding]; other site
240292002129	Walker B motif; other site
240292002130	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292002131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002132	binding surface
240292002133	TPR motif; other site
240292002134	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292002135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002136	binding surface
240292002137	TPR motif; other site
240292002138	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292002139	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292002140	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292002141	Helix-turn-helix domain; Region: HTH_28; pfam13518
240292002142	Winged helix-turn helix; Region: HTH_29; pfam13551
240292002143	Transposase domain (DUF772); Region: DUF772; pfam05598
240292002144	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292002145	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292002146	Peptidase M15; Region: Peptidase_M15_3; pfam08291
240292002147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292002148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002149	active site
240292002150	phosphorylation site [posttranslational modification]
240292002151	intermolecular recognition site; other site
240292002152	dimerization interface [polypeptide binding]; other site
240292002153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292002154	DNA binding site [nucleotide binding]
240292002155	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292002156	putative binding surface; other site
240292002157	active site
240292002158	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002160	active site
240292002161	phosphorylation site [posttranslational modification]
240292002162	intermolecular recognition site; other site
240292002163	dimerization interface [polypeptide binding]; other site
240292002164	PAS domain S-box; Region: sensory_box; TIGR00229
240292002165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002166	putative active site [active]
240292002167	heme pocket [chemical binding]; other site
240292002168	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292002169	GAF domain; Region: GAF; pfam01590
240292002170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002171	PAS fold; Region: PAS_3; pfam08447
240292002172	putative active site [active]
240292002173	heme pocket [chemical binding]; other site
240292002174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002175	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292002176	putative active site [active]
240292002177	heme pocket [chemical binding]; other site
240292002178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002179	dimer interface [polypeptide binding]; other site
240292002180	phosphorylation site [posttranslational modification]
240292002181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002182	ATP binding site [chemical binding]; other site
240292002183	Mg2+ binding site [ion binding]; other site
240292002184	G-X-G motif; other site
240292002185	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002187	active site
240292002188	phosphorylation site [posttranslational modification]
240292002189	intermolecular recognition site; other site
240292002190	dimerization interface [polypeptide binding]; other site
240292002191	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292002192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002193	active site
240292002194	phosphorylation site [posttranslational modification]
240292002195	intermolecular recognition site; other site
240292002196	dimerization interface [polypeptide binding]; other site
240292002197	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292002198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002199	active site
240292002200	phosphorylation site [posttranslational modification]
240292002201	intermolecular recognition site; other site
240292002202	dimerization interface [polypeptide binding]; other site
240292002203	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
240292002204	Family of unknown function (DUF490); Region: DUF490; pfam04357
240292002205	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
240292002206	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
240292002207	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
240292002208	putative active site [active]
240292002209	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
240292002210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292002211	dimer interface [polypeptide binding]; other site
240292002212	conserved gate region; other site
240292002213	putative PBP binding loops; other site
240292002214	ABC-ATPase subunit interface; other site
240292002215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292002216	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
240292002217	Walker A/P-loop; other site
240292002218	ATP binding site [chemical binding]; other site
240292002219	Q-loop/lid; other site
240292002220	ABC transporter signature motif; other site
240292002221	Walker B; other site
240292002222	D-loop; other site
240292002223	H-loop/switch region; other site
240292002224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292002225	putative substrate translocation pore; other site
240292002226	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292002227	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
240292002228	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
240292002229	dimer interface [polypeptide binding]; other site
240292002230	anticodon binding site; other site
240292002231	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
240292002232	homodimer interface [polypeptide binding]; other site
240292002233	motif 1; other site
240292002234	active site
240292002235	motif 2; other site
240292002236	GAD domain; Region: GAD; pfam02938
240292002237	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
240292002238	motif 3; other site
240292002239	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
240292002240	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
240292002241	YcfA-like protein; Region: YcfA; pfam07927
240292002242	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
240292002243	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292002244	G1 box; other site
240292002245	GTP/Mg2+ binding site [chemical binding]; other site
240292002246	G2 box; other site
240292002247	Switch I region; other site
240292002248	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292002249	G3 box; other site
240292002250	Switch II region; other site
240292002251	G4 box; other site
240292002252	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
240292002253	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240292002254	substrate binding site [chemical binding]; other site
240292002255	dimer interface [polypeptide binding]; other site
240292002256	ATP binding site [chemical binding]; other site
240292002257	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
240292002258	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
240292002259	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
240292002260	metal ion-dependent adhesion site (MIDAS); other site
240292002261	Predicted metal-binding protein [Function unknown]; Region: COG5469
240292002262	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
240292002263	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
240292002264	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
240292002265	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292002266	S-layer homology domain; Region: SLH; pfam00395
240292002267	S-layer homology domain; Region: SLH; pfam00395
240292002268	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292002269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292002270	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292002271	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
240292002272	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
240292002273	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
240292002274	generic binding surface II; other site
240292002275	generic binding surface I; other site
240292002276	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
240292002277	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
240292002278	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
240292002279	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292002280	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292002281	active site
240292002282	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292002283	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292002284	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292002285	active site
240292002286	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292002287	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292002288	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292002289	active site
240292002290	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
240292002291	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
240292002292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
240292002293	putative mechanosensitive channel protein; Provisional; Region: PRK10929
240292002294	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
240292002295	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292002296	putative metal binding site; other site
240292002297	Uncharacterized conserved protein [Function unknown]; Region: COG2928
240292002298	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
240292002299	putative RNA binding site [nucleotide binding]; other site
240292002300	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
240292002301	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
240292002302	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
240292002303	P loop; other site
240292002304	GTP binding site [chemical binding]; other site
240292002305	GAF domain; Region: GAF_3; pfam13492
240292002306	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240292002307	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240292002308	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
240292002309	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
240292002310	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
240292002311	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
240292002312	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
240292002313	CoA-binding site [chemical binding]; other site
240292002314	ATP-binding [chemical binding]; other site
240292002315	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292002316	Predicted membrane protein [Function unknown]; Region: COG3431
240292002317	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
240292002318	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
240292002319	P-loop, Walker A motif; other site
240292002320	Base recognition motif; other site
240292002321	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292002322	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
240292002323	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292002324	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292002325	structural tetrad; other site
240292002326	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
240292002327	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
240292002328	intersubunit interface [polypeptide binding]; other site
240292002329	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002330	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292002331	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002332	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002333	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292002334	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292002335	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
240292002336	C-terminal domain interface [polypeptide binding]; other site
240292002337	GSH binding site (G-site) [chemical binding]; other site
240292002338	dimer interface [polypeptide binding]; other site
240292002339	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
240292002340	N-terminal domain interface [polypeptide binding]; other site
240292002341	dimer interface [polypeptide binding]; other site
240292002342	substrate binding pocket (H-site) [chemical binding]; other site
240292002343	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
240292002344	Right handed beta helix region; Region: Beta_helix; pfam13229
240292002345	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
240292002346	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292002347	NAD binding site [chemical binding]; other site
240292002348	substrate binding site [chemical binding]; other site
240292002349	active site
240292002350	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
240292002351	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
240292002352	putative NAD(P) binding site [chemical binding]; other site
240292002353	active site
240292002354	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
240292002355	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
240292002356	nucleotide binding site [chemical binding]; other site
240292002357	NEF interaction site [polypeptide binding]; other site
240292002358	SBD interface [polypeptide binding]; other site
240292002359	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
240292002360	Peptidase family U32; Region: Peptidase_U32; pfam01136
240292002361	Collagenase; Region: DUF3656; pfam12392
240292002362	Peptidase family U32; Region: Peptidase_U32; cl03113
240292002363	Helix-turn-helix domain; Region: HTH_36; pfam13730
240292002364	Uncharacterized conserved protein [Function unknown]; Region: COG1434
240292002365	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240292002366	putative active site [active]
240292002367	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
240292002368	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240292002369	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240292002370	protein binding site [polypeptide binding]; other site
240292002371	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
240292002372	Catalytic dyad [active]
240292002373	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292002374	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292002375	active site
240292002376	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292002377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002378	active site
240292002379	phosphorylation site [posttranslational modification]
240292002380	intermolecular recognition site; other site
240292002381	dimerization interface [polypeptide binding]; other site
240292002382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292002383	DNA binding residues [nucleotide binding]
240292002384	dimerization interface [polypeptide binding]; other site
240292002385	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
240292002386	Double zinc ribbon; Region: DZR; pfam12773
240292002387	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240292002388	Protein phosphatase 2C; Region: PP2C; pfam00481
240292002389	active site
240292002390	CHAT domain; Region: CHAT; cl17868
240292002391	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292002392	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292002393	phosphopeptide binding site; other site
240292002394	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292002395	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292002396	phosphopeptide binding site; other site
240292002397	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
240292002398	hypothetical protein; Provisional; Region: PRK06208
240292002399	intersubunit interface [polypeptide binding]; other site
240292002400	active site
240292002401	Zn2+ binding site [ion binding]; other site
240292002402	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
240292002403	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
240292002404	putative NAD(P) binding site [chemical binding]; other site
240292002405	putative active site [active]
240292002406	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
240292002407	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
240292002408	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
240292002409	nucleotide binding pocket [chemical binding]; other site
240292002410	K-X-D-G motif; other site
240292002411	catalytic site [active]
240292002412	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
240292002413	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
240292002414	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
240292002415	Dimer interface [polypeptide binding]; other site
240292002416	BRCT sequence motif; other site
240292002417	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
240292002418	CheB methylesterase; Region: CheB_methylest; pfam01339
240292002419	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
240292002420	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
240292002421	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
240292002422	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
240292002423	PAS domain; Region: PAS_10; pfam13596
240292002424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292002425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002426	dimer interface [polypeptide binding]; other site
240292002427	phosphorylation site [posttranslational modification]
240292002428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002429	ATP binding site [chemical binding]; other site
240292002430	Mg2+ binding site [ion binding]; other site
240292002431	G-X-G motif; other site
240292002432	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002434	active site
240292002435	phosphorylation site [posttranslational modification]
240292002436	intermolecular recognition site; other site
240292002437	dimerization interface [polypeptide binding]; other site
240292002438	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
240292002439	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
240292002440	active site
240292002441	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
240292002442	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
240292002443	Zn binding site [ion binding]; other site
240292002444	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
240292002445	ABC1 family; Region: ABC1; cl17513
240292002446	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292002447	active site
240292002448	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
240292002449	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
240292002450	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292002451	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292002452	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292002453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292002454	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240292002455	Walker A/P-loop; other site
240292002456	ATP binding site [chemical binding]; other site
240292002457	Q-loop/lid; other site
240292002458	ABC transporter signature motif; other site
240292002459	Walker B; other site
240292002460	D-loop; other site
240292002461	H-loop/switch region; other site
240292002462	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
240292002463	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292002464	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292002465	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
240292002466	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
240292002467	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
240292002468	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
240292002469	replicative DNA helicase; Region: DnaB; TIGR00665
240292002470	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
240292002471	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
240292002472	Walker A motif; other site
240292002473	ATP binding site [chemical binding]; other site
240292002474	Walker B motif; other site
240292002475	DNA binding loops [nucleotide binding]
240292002476	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
240292002477	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
240292002478	Uncharacterized conserved protein [Function unknown]; Region: COG3937
240292002479	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
240292002480	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
240292002481	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
240292002482	cyanophycin synthetase; Provisional; Region: PRK14016
240292002483	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
240292002484	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
240292002485	proposed catalytic triad [active]
240292002486	active site nucleophile [active]
240292002487	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
240292002488	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292002489	catalytic residues [active]
240292002490	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
240292002491	4Fe-4S binding domain; Region: Fer4; pfam00037
240292002492	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292002493	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
240292002494	Uncharacterized conserved protein [Function unknown]; Region: COG5607
240292002495	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
240292002496	MltA specific insert domain; Region: MltA; pfam03562
240292002497	3D domain; Region: 3D; pfam06725
240292002498	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
240292002499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002500	TPR repeat; Region: TPR_11; pfam13414
240292002501	binding surface
240292002502	TPR motif; other site
240292002503	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
240292002504	Transposase IS200 like; Region: Y1_Tnp; cl00848
240292002505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002506	binding surface
240292002507	TPR repeat; Region: TPR_11; pfam13414
240292002508	TPR motif; other site
240292002509	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292002510	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
240292002511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292002512	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292002513	hypothetical protein; Reviewed; Region: PRK12275
240292002514	four helix bundle protein; Region: TIGR02436
240292002515	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292002516	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292002517	phosphopeptide binding site; other site
240292002518	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292002519	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292002520	active site
240292002521	ATP binding site [chemical binding]; other site
240292002522	substrate binding site [chemical binding]; other site
240292002523	activation loop (A-loop); other site
240292002524	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
240292002525	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
240292002526	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292002527	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240292002528	active site
240292002529	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292002530	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002531	putative active site [active]
240292002532	heme pocket [chemical binding]; other site
240292002533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292002534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002535	dimer interface [polypeptide binding]; other site
240292002536	phosphorylation site [posttranslational modification]
240292002537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002538	ATP binding site [chemical binding]; other site
240292002539	Mg2+ binding site [ion binding]; other site
240292002540	G-X-G motif; other site
240292002541	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
240292002542	pseudouridine synthase; Region: TIGR00093
240292002543	probable active site [active]
240292002544	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
240292002545	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
240292002546	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292002547	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
240292002548	putative acyl-acceptor binding pocket; other site
240292002549	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
240292002550	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
240292002551	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
240292002552	PAS fold; Region: PAS_4; pfam08448
240292002553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002554	putative active site [active]
240292002555	heme pocket [chemical binding]; other site
240292002556	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292002557	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002558	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292002559	putative active site [active]
240292002560	heme pocket [chemical binding]; other site
240292002561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002562	putative active site [active]
240292002563	heme pocket [chemical binding]; other site
240292002564	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292002565	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292002566	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292002567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002568	dimer interface [polypeptide binding]; other site
240292002569	phosphorylation site [posttranslational modification]
240292002570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002571	ATP binding site [chemical binding]; other site
240292002572	Mg2+ binding site [ion binding]; other site
240292002573	G-X-G motif; other site
240292002574	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292002575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002576	active site
240292002577	phosphorylation site [posttranslational modification]
240292002578	intermolecular recognition site; other site
240292002579	dimerization interface [polypeptide binding]; other site
240292002580	Transposase domain (DUF772); Region: DUF772; pfam05598
240292002581	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292002582	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
240292002583	catalytic triad [active]
240292002584	putative active site [active]
240292002585	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
240292002586	Uncharacterized conserved protein [Function unknown]; Region: COG3349
240292002587	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292002588	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
240292002589	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
240292002590	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
240292002591	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292002592	putative active site [active]
240292002593	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
240292002594	NAD(P) binding pocket [chemical binding]; other site
240292002595	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
240292002596	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240292002597	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240292002598	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
240292002599	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
240292002600	Walker A motif; other site
240292002601	ATP binding site [chemical binding]; other site
240292002602	Walker B motif; other site
240292002603	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
240292002604	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
240292002605	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
240292002606	Walker A motif; other site
240292002607	ATP binding site [chemical binding]; other site
240292002608	Walker B motif; other site
240292002609	GrpE; Region: GrpE; pfam01025
240292002610	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
240292002611	dimer interface [polypeptide binding]; other site
240292002612	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
240292002613	molecular chaperone DnaK; Provisional; Region: PRK13411
240292002614	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
240292002615	nucleotide binding site [chemical binding]; other site
240292002616	NEF interaction site [polypeptide binding]; other site
240292002617	SBD interface [polypeptide binding]; other site
240292002618	chaperone protein DnaJ; Provisional; Region: PRK14293
240292002619	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292002620	HSP70 interaction site [polypeptide binding]; other site
240292002621	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
240292002622	Zn binding sites [ion binding]; other site
240292002623	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240292002624	dimer interface [polypeptide binding]; other site
240292002625	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
240292002626	CPxP  motif; other site
240292002627	GTPase RsgA; Reviewed; Region: PRK12289
240292002628	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
240292002629	GTPase/Zn-binding domain interface [polypeptide binding]; other site
240292002630	GTP/Mg2+ binding site [chemical binding]; other site
240292002631	G4 box; other site
240292002632	G5 box; other site
240292002633	G1 box; other site
240292002634	Switch I region; other site
240292002635	G2 box; other site
240292002636	G3 box; other site
240292002637	Switch II region; other site
240292002638	Uncharacterized conserved protein [Function unknown]; Region: COG1543
240292002639	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
240292002640	active site
240292002641	substrate binding site [chemical binding]; other site
240292002642	catalytic site [active]
240292002643	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
240292002644	YxiJ-like protein; Region: YxiJ; pfam14176
240292002645	apocytochrome f; Reviewed; Region: PRK02693
240292002646	cytochrome f; Region: petA; CHL00037
240292002647	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
240292002648	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
240292002649	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
240292002650	cytochrome b subunit interaction site [polypeptide binding]; other site
240292002651	[2Fe-2S] cluster binding site [ion binding]; other site
240292002652	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
240292002653	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
240292002654	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292002655	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292002656	active site
240292002657	alanine racemase; Reviewed; Region: alr; PRK00053
240292002658	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
240292002659	active site
240292002660	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240292002661	dimer interface [polypeptide binding]; other site
240292002662	substrate binding site [chemical binding]; other site
240292002663	catalytic residues [active]
240292002664	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
240292002665	AAA ATPase domain; Region: AAA_16; pfam13191
240292002666	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
240292002667	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
240292002668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292002669	Walker A motif; other site
240292002670	ATP binding site [chemical binding]; other site
240292002671	Walker B motif; other site
240292002672	Small integral membrane protein [Function unknown]; Region: COG5548
240292002673	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
240292002674	Phosphotransferase enzyme family; Region: APH; pfam01636
240292002675	substrate binding site [chemical binding]; other site
240292002676	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
240292002677	active site
240292002678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292002679	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
240292002680	nucleotide binding site/active site [active]
240292002681	HIT family signature motif; other site
240292002682	catalytic residue [active]
240292002683	Uncharacterized conserved protein [Function unknown]; Region: COG1434
240292002684	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240292002685	putative active site [active]
240292002686	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
240292002687	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240292002688	active site
240292002689	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
240292002690	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240292002691	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
240292002692	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
240292002693	metal binding site 2 [ion binding]; metal-binding site
240292002694	putative DNA binding helix; other site
240292002695	metal binding site 1 [ion binding]; metal-binding site
240292002696	dimer interface [polypeptide binding]; other site
240292002697	structural Zn2+ binding site [ion binding]; other site
240292002698	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
240292002699	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
240292002700	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
240292002701	putative active site [active]
240292002702	catalytic triad [active]
240292002703	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292002704	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292002705	Transcriptional regulator [Transcription]; Region: LytR; COG1316
240292002706	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
240292002707	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
240292002708	PAS domain S-box; Region: sensory_box; TIGR00229
240292002709	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002710	putative active site [active]
240292002711	heme pocket [chemical binding]; other site
240292002712	PAS domain S-box; Region: sensory_box; TIGR00229
240292002713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292002714	putative active site [active]
240292002715	heme pocket [chemical binding]; other site
240292002716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292002717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292002718	dimer interface [polypeptide binding]; other site
240292002719	phosphorylation site [posttranslational modification]
240292002720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002721	ATP binding site [chemical binding]; other site
240292002722	Mg2+ binding site [ion binding]; other site
240292002723	G-X-G motif; other site
240292002724	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
240292002725	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
240292002726	active site
240292002727	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
240292002728	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
240292002729	active site
240292002730	(T/H)XGH motif; other site
240292002731	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
240292002732	nudix motif; other site
240292002733	NAD synthetase; Provisional; Region: PRK13981
240292002734	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
240292002735	multimer interface [polypeptide binding]; other site
240292002736	active site
240292002737	catalytic triad [active]
240292002738	protein interface 1 [polypeptide binding]; other site
240292002739	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
240292002740	homodimer interface [polypeptide binding]; other site
240292002741	NAD binding pocket [chemical binding]; other site
240292002742	ATP binding pocket [chemical binding]; other site
240292002743	Mg binding site [ion binding]; other site
240292002744	active-site loop [active]
240292002745	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292002746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292002747	Walker A/P-loop; other site
240292002748	ATP binding site [chemical binding]; other site
240292002749	Q-loop/lid; other site
240292002750	ABC transporter signature motif; other site
240292002751	Walker B; other site
240292002752	D-loop; other site
240292002753	H-loop/switch region; other site
240292002754	TPR repeat; Region: TPR_11; pfam13414
240292002755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292002756	binding surface
240292002757	TPR motif; other site
240292002758	TPR repeat; Region: TPR_11; pfam13414
240292002759	TPR repeat; Region: TPR_11; pfam13414
240292002760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292002761	binding surface
240292002762	TPR motif; other site
240292002763	Uncharacterized conserved protein [Function unknown]; Region: COG0393
240292002764	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
240292002765	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
240292002766	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292002767	putative DNA binding site [nucleotide binding]; other site
240292002768	putative Zn2+ binding site [ion binding]; other site
240292002769	Transcriptional regulator PadR-like family; Region: PadR; cl17335
240292002770	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
240292002771	putative ABC transporter; Region: ycf24; CHL00085
240292002772	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
240292002773	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
240292002774	Walker A/P-loop; other site
240292002775	ATP binding site [chemical binding]; other site
240292002776	Q-loop/lid; other site
240292002777	ABC transporter signature motif; other site
240292002778	Walker B; other site
240292002779	D-loop; other site
240292002780	H-loop/switch region; other site
240292002781	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
240292002782	FeS assembly protein SufD; Region: sufD; TIGR01981
240292002783	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
240292002784	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
240292002785	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292002786	catalytic residue [active]
240292002787	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
240292002788	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
240292002789	active site
240292002790	homodimer interface [polypeptide binding]; other site
240292002791	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
240292002792	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240292002793	Transposase [DNA replication, recombination, and repair]; Region: COG5433
240292002794	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
240292002795	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
240292002796	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240292002797	protein binding site [polypeptide binding]; other site
240292002798	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
240292002799	Catalytic dyad [active]
240292002800	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
240292002801	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
240292002802	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
240292002803	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292002804	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292002805	active site
240292002806	ATP binding site [chemical binding]; other site
240292002807	substrate binding site [chemical binding]; other site
240292002808	activation loop (A-loop); other site
240292002809	putative pectinesterase; Region: PLN02432; cl01911
240292002810	Right handed beta helix region; Region: Beta_helix; pfam13229
240292002811	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
240292002812	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
240292002813	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240292002814	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240292002815	catalytic triad [active]
240292002816	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240292002817	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240292002818	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292002819	catalytic residue [active]
240292002820	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
240292002821	proposed catalytic triad [active]
240292002822	active site nucleophile [active]
240292002823	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292002824	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292002825	GTP-binding protein LepA; Provisional; Region: PRK05433
240292002826	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
240292002827	G1 box; other site
240292002828	putative GEF interaction site [polypeptide binding]; other site
240292002829	GTP/Mg2+ binding site [chemical binding]; other site
240292002830	Switch I region; other site
240292002831	G2 box; other site
240292002832	G3 box; other site
240292002833	Switch II region; other site
240292002834	G4 box; other site
240292002835	G5 box; other site
240292002836	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
240292002837	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
240292002838	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
240292002839	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
240292002840	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
240292002841	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
240292002842	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
240292002843	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
240292002844	catalytic triad [active]
240292002845	Ferredoxin [Energy production and conversion]; Region: COG1146
240292002846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292002847	non-specific DNA binding site [nucleotide binding]; other site
240292002848	salt bridge; other site
240292002849	sequence-specific DNA binding site [nucleotide binding]; other site
240292002850	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
240292002851	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292002852	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
240292002853	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240292002854	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240292002855	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
240292002856	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240292002857	Subunit I/III interface [polypeptide binding]; other site
240292002858	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
240292002859	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
240292002860	putative catalytic residues [active]
240292002861	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240292002862	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240292002863	dimer interface [polypeptide binding]; other site
240292002864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292002865	catalytic residue [active]
240292002866	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
240292002867	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
240292002868	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
240292002869	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
240292002870	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
240292002871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292002872	dimer interface [polypeptide binding]; other site
240292002873	conserved gate region; other site
240292002874	putative PBP binding loops; other site
240292002875	ABC-ATPase subunit interface; other site
240292002876	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
240292002877	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292002878	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292002879	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292002880	putative switch regulator; other site
240292002881	non-specific DNA interactions [nucleotide binding]; other site
240292002882	DNA binding site [nucleotide binding]
240292002883	sequence specific DNA binding site [nucleotide binding]; other site
240292002884	putative cAMP binding site [chemical binding]; other site
240292002885	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
240292002886	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
240292002887	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
240292002888	putative ligand binding site [chemical binding]; other site
240292002889	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
240292002890	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
240292002891	TM-ABC transporter signature motif; other site
240292002892	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292002893	putative active site [active]
240292002894	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
240292002895	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
240292002896	Walker A/P-loop; other site
240292002897	ATP binding site [chemical binding]; other site
240292002898	Q-loop/lid; other site
240292002899	ABC transporter signature motif; other site
240292002900	Walker B; other site
240292002901	D-loop; other site
240292002902	H-loop/switch region; other site
240292002903	Homeodomain-like domain; Region: HTH_23; pfam13384
240292002904	Winged helix-turn helix; Region: HTH_29; pfam13551
240292002905	Winged helix-turn helix; Region: HTH_33; pfam13592
240292002906	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292002907	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
240292002908	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
240292002909	Walker A/P-loop; other site
240292002910	ATP binding site [chemical binding]; other site
240292002911	Q-loop/lid; other site
240292002912	ABC transporter signature motif; other site
240292002913	Walker B; other site
240292002914	D-loop; other site
240292002915	H-loop/switch region; other site
240292002916	dihydrodipicolinate reductase; Provisional; Region: PRK00048
240292002917	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
240292002918	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
240292002919	precorrin-8X methylmutase; Validated; Region: PRK05953
240292002920	Precorrin-8X methylmutase; Region: CbiC; pfam02570
240292002921	Repair protein; Region: Repair_PSII; pfam04536
240292002922	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
240292002923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292002924	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
240292002925	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292002926	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292002927	DNA binding residues [nucleotide binding]
240292002928	dimerization interface [polypeptide binding]; other site
240292002929	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240292002930	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292002931	catalytic triad [active]
240292002932	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
240292002933	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
240292002934	propionate/acetate kinase; Provisional; Region: PRK12379
240292002935	transaldolase-like protein; Provisional; Region: PTZ00411
240292002936	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
240292002937	active site
240292002938	dimer interface [polypeptide binding]; other site
240292002939	catalytic residue [active]
240292002940	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
240292002941	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
240292002942	domain interfaces; other site
240292002943	active site
240292002944	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
240292002945	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
240292002946	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
240292002947	putative phosphoketolase; Provisional; Region: PRK05261
240292002948	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
240292002949	TPP-binding site; other site
240292002950	XFP C-terminal domain; Region: XFP_C; pfam09363
240292002951	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
240292002952	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
240292002953	Predicted transcriptional regulator [Transcription]; Region: COG3682
240292002954	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
240292002955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292002956	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
240292002957	catalytic motif [active]
240292002958	Catalytic residue [active]
240292002959	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292002960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292002961	S-adenosylmethionine binding site [chemical binding]; other site
240292002962	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292002963	putative binding surface; other site
240292002964	active site
240292002965	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
240292002966	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
240292002967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292002968	ATP binding site [chemical binding]; other site
240292002969	Mg2+ binding site [ion binding]; other site
240292002970	G-X-G motif; other site
240292002971	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
240292002972	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002974	active site
240292002975	phosphorylation site [posttranslational modification]
240292002976	intermolecular recognition site; other site
240292002977	dimerization interface [polypeptide binding]; other site
240292002978	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292002979	dimerization interface [polypeptide binding]; other site
240292002980	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
240292002981	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
240292002982	dimer interface [polypeptide binding]; other site
240292002983	putative CheW interface [polypeptide binding]; other site
240292002984	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
240292002985	Response regulator receiver domain; Region: Response_reg; pfam00072
240292002986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002987	active site
240292002988	phosphorylation site [posttranslational modification]
240292002989	intermolecular recognition site; other site
240292002990	dimerization interface [polypeptide binding]; other site
240292002991	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
240292002992	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292002993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292002994	active site
240292002995	phosphorylation site [posttranslational modification]
240292002996	intermolecular recognition site; other site
240292002997	dimerization interface [polypeptide binding]; other site
240292002998	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
240292002999	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
240292003000	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
240292003001	Ligand Binding Site [chemical binding]; other site
240292003002	KGK domain; Region: KGK; pfam08872
240292003003	cytochrome c biogenesis protein; Region: ccsA; CHL00045
240292003004	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
240292003005	Protein of unknown function (DUF98); Region: DUF98; pfam01947
240292003006	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
240292003007	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240292003008	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
240292003009	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
240292003010	Predicted integral membrane protein [Function unknown]; Region: COG0762
240292003011	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
240292003012	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
240292003013	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
240292003014	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240292003015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003016	GAF domain; Region: GAF; pfam01590
240292003017	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003018	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003019	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003020	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003021	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003022	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292003024	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003025	dimer interface [polypeptide binding]; other site
240292003026	phosphorylation site [posttranslational modification]
240292003027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003028	ATP binding site [chemical binding]; other site
240292003029	Mg2+ binding site [ion binding]; other site
240292003030	G-X-G motif; other site
240292003031	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
240292003032	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
240292003033	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
240292003034	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
240292003035	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
240292003036	CAAX protease self-immunity; Region: Abi; pfam02517
240292003037	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
240292003038	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292003039	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
240292003040	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
240292003041	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292003042	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
240292003043	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292003044	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240292003045	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240292003046	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
240292003047	D-pathway; other site
240292003048	Putative ubiquinol binding site [chemical binding]; other site
240292003049	Low-spin heme (heme b) binding site [chemical binding]; other site
240292003050	Putative water exit pathway; other site
240292003051	Binuclear center (heme o3/CuB) [ion binding]; other site
240292003052	K-pathway; other site
240292003053	Putative proton exit pathway; other site
240292003054	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240292003055	Subunit I/III interface [polypeptide binding]; other site
240292003056	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
240292003057	Inward rectifier potassium channel; Region: IRK; pfam01007
240292003058	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240292003059	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
240292003060	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
240292003061	Pheophorbide a oxygenase; Region: PaO; pfam08417
240292003062	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
240292003063	metal binding site 2 [ion binding]; metal-binding site
240292003064	putative DNA binding helix; other site
240292003065	metal binding site 1 [ion binding]; metal-binding site
240292003066	dimer interface [polypeptide binding]; other site
240292003067	structural Zn2+ binding site [ion binding]; other site
240292003068	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292003069	Response regulator receiver domain; Region: Response_reg; pfam00072
240292003070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003071	active site
240292003072	intermolecular recognition site; other site
240292003073	dimerization interface [polypeptide binding]; other site
240292003074	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
240292003075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
240292003076	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292003077	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
240292003078	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
240292003079	GTP binding site; other site
240292003080	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292003081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292003082	TPR motif; other site
240292003083	binding surface
240292003084	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292003085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292003086	TPR motif; other site
240292003087	binding surface
240292003088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292003089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292003090	binding surface
240292003091	TPR motif; other site
240292003092	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292003093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292003094	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
240292003095	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
240292003096	catalytic residues [active]
240292003097	Clp protease; Region: CLP_protease; pfam00574
240292003098	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
240292003099	oligomer interface [polypeptide binding]; other site
240292003100	active site residues [active]
240292003101	Exoribonuclease R [Transcription]; Region: VacB; COG0557
240292003102	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
240292003103	RNB domain; Region: RNB; pfam00773
240292003104	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
240292003105	RNA binding site [nucleotide binding]; other site
240292003106	aromatic acid decarboxylase; Validated; Region: PRK05920
240292003107	Flavoprotein; Region: Flavoprotein; pfam02441
240292003108	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
240292003109	shikimate kinase; Reviewed; Region: aroK; PRK00131
240292003110	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
240292003111	ADP binding site [chemical binding]; other site
240292003112	magnesium binding site [ion binding]; other site
240292003113	putative shikimate binding site; other site
240292003114	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
240292003115	feedback inhibition sensing region; other site
240292003116	homohexameric interface [polypeptide binding]; other site
240292003117	nucleotide binding site [chemical binding]; other site
240292003118	N-acetyl-L-glutamate binding site [chemical binding]; other site
240292003119	Outer membrane lipoprotein; Region: YfiO; pfam13525
240292003120	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
240292003121	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
240292003122	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
240292003123	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
240292003124	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292003125	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292003126	Predicted membrane protein [Function unknown]; Region: COG4330
240292003127	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292003128	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
240292003129	putative acyl-acceptor binding pocket; other site
240292003130	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
240292003131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292003132	dimer interface [polypeptide binding]; other site
240292003133	conserved gate region; other site
240292003134	putative PBP binding loops; other site
240292003135	ABC-ATPase subunit interface; other site
240292003136	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
240292003137	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
240292003138	active site
240292003139	substrate binding site [chemical binding]; other site
240292003140	cosubstrate binding site; other site
240292003141	catalytic site [active]
240292003142	CAAX protease self-immunity; Region: Abi; pfam02517
240292003143	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
240292003144	Archaeal protein of unknown function (DUF650); Region: DUF650; pfam04894
240292003145	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292003146	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292003147	catalytic loop [active]
240292003148	iron binding site [ion binding]; other site
240292003149	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
240292003150	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
240292003151	substrate binding site [chemical binding]; other site
240292003152	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
240292003153	substrate binding site [chemical binding]; other site
240292003154	ligand binding site [chemical binding]; other site
240292003155	AIPR protein; Region: AIPR; pfam10592
240292003156	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
240292003157	putative active site [active]
240292003158	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
240292003159	rod shape-determining protein MreB; Provisional; Region: PRK13930
240292003160	nucleotide binding site [chemical binding]; other site
240292003161	putative NEF/HSP70 interaction site [polypeptide binding]; other site
240292003162	SBD interface [polypeptide binding]; other site
240292003163	UV damage repair endonuclease [DNA replication, recombination, and repair]; Region: Uve; COG4294
240292003164	FtsH Extracellular; Region: FtsH_ext; pfam06480
240292003165	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
240292003166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292003167	Walker A motif; other site
240292003168	ATP binding site [chemical binding]; other site
240292003169	Walker B motif; other site
240292003170	arginine finger; other site
240292003171	Peptidase family M41; Region: Peptidase_M41; pfam01434
240292003172	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
240292003173	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
240292003174	homodimer interface [polypeptide binding]; other site
240292003175	substrate-cofactor binding pocket; other site
240292003176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292003177	catalytic residue [active]
240292003178	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
240292003179	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292003180	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
240292003181	DNA polymerase I; Provisional; Region: PRK05755
240292003182	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
240292003183	active site
240292003184	metal binding site 1 [ion binding]; metal-binding site
240292003185	putative 5' ssDNA interaction site; other site
240292003186	metal binding site 3; metal-binding site
240292003187	metal binding site 2 [ion binding]; metal-binding site
240292003188	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
240292003189	putative DNA binding site [nucleotide binding]; other site
240292003190	putative metal binding site [ion binding]; other site
240292003191	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
240292003192	active site
240292003193	catalytic site [active]
240292003194	substrate binding site [chemical binding]; other site
240292003195	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
240292003196	active site
240292003197	DNA binding site [nucleotide binding]
240292003198	catalytic site [active]
240292003199	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
240292003200	Family description; Region: VCBS; pfam13517
240292003201	Family description; Region: VCBS; pfam13517
240292003202	Family description; Region: VCBS; pfam13517
240292003203	Family description; Region: VCBS; pfam13517
240292003204	Family description; Region: VCBS; pfam13517
240292003205	Cadherin repeat-like domain; Region: CA_like; cl15786
240292003206	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
240292003207	Ca2+ binding site [ion binding]; other site
240292003208	Cadherin repeat-like domain; Region: CA_like; cl15786
240292003209	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
240292003210	Ca2+ binding site [ion binding]; other site
240292003211	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
240292003212	putative hydrophobic ligand binding site [chemical binding]; other site
240292003213	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
240292003214	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
240292003215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292003216	FeS/SAM binding site; other site
240292003217	Uncharacterized conserved protein [Function unknown]; Region: COG4095
240292003218	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
240292003219	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
240292003220	Tetramer interface [polypeptide binding]; other site
240292003221	active site
240292003222	FMN-binding site [chemical binding]; other site
240292003223	BolA-like protein; Region: BolA; pfam01722
240292003224	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
240292003225	putative GSH binding site [chemical binding]; other site
240292003226	catalytic residues [active]
240292003227	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
240292003228	MPT binding site; other site
240292003229	trimer interface [polypeptide binding]; other site
240292003230	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
240292003231	V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496
240292003232	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
240292003233	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292003234	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292003235	Walker A/P-loop; other site
240292003236	ATP binding site [chemical binding]; other site
240292003237	Q-loop/lid; other site
240292003238	ABC transporter signature motif; other site
240292003239	Walker B; other site
240292003240	D-loop; other site
240292003241	H-loop/switch region; other site
240292003242	DevC protein; Region: devC; TIGR01185
240292003243	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292003244	FtsX-like permease family; Region: FtsX; pfam02687
240292003245	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292003246	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292003247	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292003248	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292003249	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292003250	RDD family; Region: RDD; pfam06271
240292003251	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292003252	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003253	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003254	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003255	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003256	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003257	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
240292003258	EamA-like transporter family; Region: EamA; pfam00892
240292003259	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
240292003260	EamA-like transporter family; Region: EamA; pfam00892
240292003261	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003262	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003264	dimer interface [polypeptide binding]; other site
240292003265	phosphorylation site [posttranslational modification]
240292003266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003267	ATP binding site [chemical binding]; other site
240292003268	Mg2+ binding site [ion binding]; other site
240292003269	G-X-G motif; other site
240292003270	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
240292003271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003272	dimer interface [polypeptide binding]; other site
240292003273	phosphorylation site [posttranslational modification]
240292003274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003275	ATP binding site [chemical binding]; other site
240292003276	Mg2+ binding site [ion binding]; other site
240292003277	G-X-G motif; other site
240292003278	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
240292003279	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292003280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003281	active site
240292003282	phosphorylation site [posttranslational modification]
240292003283	intermolecular recognition site; other site
240292003284	dimerization interface [polypeptide binding]; other site
240292003285	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292003286	DNA binding site [nucleotide binding]
240292003287	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240292003288	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292003289	AAA domain; Region: AAA_14; pfam13173
240292003290	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292003291	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
240292003292	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292003293	active site
240292003294	metal binding site [ion binding]; metal-binding site
240292003295	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292003296	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
240292003297	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292003298	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292003299	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
240292003300	putative active site [active]
240292003301	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292003302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292003303	Walker A/P-loop; other site
240292003304	ATP binding site [chemical binding]; other site
240292003305	Q-loop/lid; other site
240292003306	ABC transporter signature motif; other site
240292003307	Walker B; other site
240292003308	D-loop; other site
240292003309	H-loop/switch region; other site
240292003310	hydrolase, alpha/beta fold family protein; Region: PLN02824
240292003311	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
240292003312	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292003313	putative catalytic residue [active]
240292003314	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
240292003315	putative nucleotide binding site [chemical binding]; other site
240292003316	uridine monophosphate binding site [chemical binding]; other site
240292003317	homohexameric interface [polypeptide binding]; other site
240292003318	ribosome recycling factor; Reviewed; Region: frr; PRK00083
240292003319	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
240292003320	hinge region; other site
240292003321	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
240292003322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292003323	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292003324	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
240292003325	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
240292003326	Protein of unknown function (DUF512); Region: DUF512; pfam04459
240292003327	Bacitracin resistance protein BacA; Region: BacA; pfam02673
240292003328	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
240292003329	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
240292003330	L-aspartate oxidase; Provisional; Region: PRK07395
240292003331	L-aspartate oxidase; Provisional; Region: PRK06175
240292003332	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240292003333	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292003334	CHASE2 domain; Region: CHASE2; pfam05226
240292003335	PAS domain S-box; Region: sensory_box; TIGR00229
240292003336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003337	putative active site [active]
240292003338	heme pocket [chemical binding]; other site
240292003339	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292003340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292003341	metal binding site [ion binding]; metal-binding site
240292003342	active site
240292003343	I-site; other site
240292003344	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
240292003345	substrate binding site [chemical binding]; other site
240292003346	putative active site [active]
240292003347	redox center [active]
240292003348	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292003349	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
240292003350	phosphate binding site [ion binding]; other site
240292003351	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
240292003352	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
240292003353	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292003354	FeS/SAM binding site; other site
240292003355	TRAM domain; Region: TRAM; cl01282
240292003356	helicase 45; Provisional; Region: PTZ00424
240292003357	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
240292003358	ATP binding site [chemical binding]; other site
240292003359	Mg++ binding site [ion binding]; other site
240292003360	motif III; other site
240292003361	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292003362	nucleotide binding region [chemical binding]; other site
240292003363	ATP-binding site [chemical binding]; other site
240292003364	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292003365	putative active site [active]
240292003366	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292003367	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292003368	active site
240292003369	catalytic tetrad [active]
240292003370	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
240292003371	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
240292003372	FMN binding site [chemical binding]; other site
240292003373	active site
240292003374	catalytic residues [active]
240292003375	substrate binding site [chemical binding]; other site
240292003376	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
240292003377	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292003378	FOG: CBS domain [General function prediction only]; Region: COG0517
240292003379	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292003380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003381	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292003382	putative active site [active]
240292003383	heme pocket [chemical binding]; other site
240292003384	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
240292003385	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292003386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003387	putative active site [active]
240292003388	heme pocket [chemical binding]; other site
240292003389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003390	putative active site [active]
240292003391	heme pocket [chemical binding]; other site
240292003392	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003393	GAF domain; Region: GAF; pfam01590
240292003394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003395	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292003396	putative active site [active]
240292003397	heme pocket [chemical binding]; other site
240292003398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003399	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292003400	putative active site [active]
240292003401	heme pocket [chemical binding]; other site
240292003402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003403	putative active site [active]
240292003404	heme pocket [chemical binding]; other site
240292003405	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003406	PAS domain; Region: PAS_9; pfam13426
240292003407	putative active site [active]
240292003408	heme pocket [chemical binding]; other site
240292003409	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292003410	PAS fold; Region: PAS_3; pfam08447
240292003411	putative active site [active]
240292003412	heme pocket [chemical binding]; other site
240292003413	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292003414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003415	dimer interface [polypeptide binding]; other site
240292003416	phosphorylation site [posttranslational modification]
240292003417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003418	ATP binding site [chemical binding]; other site
240292003419	Mg2+ binding site [ion binding]; other site
240292003420	G-X-G motif; other site
240292003421	Response regulator receiver domain; Region: Response_reg; pfam00072
240292003422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003423	active site
240292003424	phosphorylation site [posttranslational modification]
240292003425	intermolecular recognition site; other site
240292003426	dimerization interface [polypeptide binding]; other site
240292003427	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292003428	Response regulator receiver domain; Region: Response_reg; pfam00072
240292003429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003430	active site
240292003431	phosphorylation site [posttranslational modification]
240292003432	intermolecular recognition site; other site
240292003433	dimerization interface [polypeptide binding]; other site
240292003434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292003435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003436	phosphorylation site [posttranslational modification]
240292003437	dimer interface [polypeptide binding]; other site
240292003438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003439	ATP binding site [chemical binding]; other site
240292003440	Mg2+ binding site [ion binding]; other site
240292003441	G-X-G motif; other site
240292003442	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292003443	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292003444	non-specific DNA binding site [nucleotide binding]; other site
240292003445	salt bridge; other site
240292003446	sequence-specific DNA binding site [nucleotide binding]; other site
240292003447	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
240292003448	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292003449	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
240292003450	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292003451	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292003452	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
240292003453	catalytic site [active]
240292003454	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
240292003455	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292003456	Walker A/P-loop; other site
240292003457	ATP binding site [chemical binding]; other site
240292003458	Q-loop/lid; other site
240292003459	ABC transporter signature motif; other site
240292003460	Walker B; other site
240292003461	D-loop; other site
240292003462	H-loop/switch region; other site
240292003463	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
240292003464	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
240292003465	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292003466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003467	active site
240292003468	phosphorylation site [posttranslational modification]
240292003469	intermolecular recognition site; other site
240292003470	dimerization interface [polypeptide binding]; other site
240292003471	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292003472	DNA binding residues [nucleotide binding]
240292003473	dimerization interface [polypeptide binding]; other site
240292003474	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292003475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003476	active site
240292003477	phosphorylation site [posttranslational modification]
240292003478	intermolecular recognition site; other site
240292003479	dimerization interface [polypeptide binding]; other site
240292003480	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003481	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003482	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240292003483	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240292003484	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
240292003485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
240292003486	ATP binding site [chemical binding]; other site
240292003487	Mg2+ binding site [ion binding]; other site
240292003488	G-X-G motif; other site
240292003489	Domain of unknown function DUF39; Region: DUF39; pfam01837
240292003490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292003491	TPR motif; other site
240292003492	binding surface
240292003493	TPR repeat; Region: TPR_11; pfam13414
240292003494	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292003495	binding surface
240292003496	TPR motif; other site
240292003497	Predicted membrane protein [Function unknown]; Region: COG2119
240292003498	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
240292003499	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
240292003500	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
240292003501	catalytic site [active]
240292003502	putative active site [active]
240292003503	putative substrate binding site [chemical binding]; other site
240292003504	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
240292003505	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
240292003506	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
240292003507	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
240292003508	heterotetramer interface [polypeptide binding]; other site
240292003509	active site pocket [active]
240292003510	cleavage site
240292003511	stage V sporulation protein K; Region: spore_V_K; TIGR02881
240292003512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292003513	Walker A motif; other site
240292003514	ATP binding site [chemical binding]; other site
240292003515	Walker B motif; other site
240292003516	arginine finger; other site
240292003517	Uncharacterized conserved protein [Function unknown]; Region: COG2442
240292003518	threonine dehydratase; Reviewed; Region: PRK09224
240292003519	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
240292003520	tetramer interface [polypeptide binding]; other site
240292003521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292003522	catalytic residue [active]
240292003523	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
240292003524	putative Ile/Val binding site [chemical binding]; other site
240292003525	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
240292003526	putative Ile/Val binding site [chemical binding]; other site
240292003527	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
240292003528	Predicted membrane protein [Function unknown]; Region: COG5346
240292003529	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292003530	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292003531	metal binding site [ion binding]; metal-binding site
240292003532	active site
240292003533	I-site; other site
240292003534	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292003535	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292003536	active site
240292003537	catalytic tetrad [active]
240292003538	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
240292003539	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
240292003540	putative active site [active]
240292003541	catalytic site [active]
240292003542	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
240292003543	putative active site [active]
240292003544	catalytic site [active]
240292003545	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
240292003546	Transposase [DNA replication, recombination, and repair]; Region: COG5421
240292003547	Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...; Region: GLECT; cl00071
240292003548	hypothetical protein; Provisional; Region: PRK05421
240292003549	putative catalytic site [active]
240292003550	putative metal binding site [ion binding]; other site
240292003551	putative phosphate binding site [ion binding]; other site
240292003552	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292003553	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292003554	PGAP1-like protein; Region: PGAP1; pfam07819
240292003555	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003556	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292003557	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003558	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240292003559	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240292003560	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292003561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292003562	Coenzyme A binding pocket [chemical binding]; other site
240292003563	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
240292003564	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
240292003565	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
240292003566	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
240292003567	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
240292003568	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
240292003569	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
240292003570	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
240292003571	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
240292003572	putative translocon binding site; other site
240292003573	protein-rRNA interface [nucleotide binding]; other site
240292003574	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
240292003575	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
240292003576	G-X-X-G motif; other site
240292003577	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
240292003578	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
240292003579	23S rRNA interface [nucleotide binding]; other site
240292003580	5S rRNA interface [nucleotide binding]; other site
240292003581	putative antibiotic binding site [chemical binding]; other site
240292003582	L25 interface [polypeptide binding]; other site
240292003583	L27 interface [polypeptide binding]; other site
240292003584	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
240292003585	23S rRNA interface [nucleotide binding]; other site
240292003586	putative translocon interaction site; other site
240292003587	signal recognition particle (SRP54) interaction site; other site
240292003588	L23 interface [polypeptide binding]; other site
240292003589	trigger factor interaction site; other site
240292003590	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
240292003591	ribosomal protein L14; Region: rpl14; CHL00057
240292003592	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
240292003593	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
240292003594	RNA binding site [nucleotide binding]; other site
240292003595	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
240292003596	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
240292003597	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
240292003598	ribosomal protein S8; Region: rps8; CHL00042
240292003599	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
240292003600	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
240292003601	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
240292003602	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
240292003603	5S rRNA interface [nucleotide binding]; other site
240292003604	L27 interface [polypeptide binding]; other site
240292003605	23S rRNA interface [nucleotide binding]; other site
240292003606	L5 interface [polypeptide binding]; other site
240292003607	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
240292003608	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
240292003609	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
240292003610	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
240292003611	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
240292003612	SecY translocase; Region: SecY; pfam00344
240292003613	adenylate kinase; Provisional; Region: adk; PRK02496
240292003614	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
240292003615	AMP-binding site [chemical binding]; other site
240292003616	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
240292003617	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
240292003618	rRNA binding site [nucleotide binding]; other site
240292003619	predicted 30S ribosome binding site; other site
240292003620	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
240292003621	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
240292003622	30S ribosomal protein S13; Region: bact_S13; TIGR03631
240292003623	30S ribosomal protein S11; Validated; Region: PRK05309
240292003624	RNA polymerase alpha subunit; Region: rpoA; CHL00013
240292003625	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
240292003626	alphaNTD - beta interaction site [polypeptide binding]; other site
240292003627	alphaNTD homodimer interface [polypeptide binding]; other site
240292003628	alphaNTD - beta' interaction site [polypeptide binding]; other site
240292003629	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
240292003630	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
240292003631	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
240292003632	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
240292003633	dimerization interface 3.5A [polypeptide binding]; other site
240292003634	active site
240292003635	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
240292003636	23S rRNA interface [nucleotide binding]; other site
240292003637	L3 interface [polypeptide binding]; other site
240292003638	ribosomal protein S9; Region: rps9; CHL00079
240292003639	ribosomal protein L31; Validated; Region: rpl31; CHL00136
240292003640	peptide chain release factor 1; Validated; Region: prfA; PRK00591
240292003641	This domain is found in peptide chain release factors; Region: PCRF; smart00937
240292003642	RF-1 domain; Region: RF-1; pfam00472
240292003643	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
240292003644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240292003645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240292003646	ABC transporter; Region: ABC_tran_2; pfam12848
240292003647	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240292003648	phosphoglyceromutase; Provisional; Region: PRK05434
240292003649	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
240292003650	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
240292003651	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
240292003652	active site
240292003653	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292003654	putative active site [active]
240292003655	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292003656	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292003657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292003658	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292003659	putative substrate translocation pore; other site
240292003660	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
240292003661	Recombination protein O N terminal; Region: RecO_N; pfam11967
240292003662	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
240292003663	intersubunit interface [polypeptide binding]; other site
240292003664	active site
240292003665	catalytic residue [active]
240292003666	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
240292003667	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292003668	cofactor binding site; other site
240292003669	DNA binding site [nucleotide binding]
240292003670	substrate interaction site [chemical binding]; other site
240292003671	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
240292003672	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
240292003673	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292003674	G1 box; other site
240292003675	GTP/Mg2+ binding site [chemical binding]; other site
240292003676	Switch I region; other site
240292003677	G3 box; other site
240292003678	Switch II region; other site
240292003679	G4 box; other site
240292003680	G5 box; other site
240292003681	Domain of unknown function (DUF697); Region: DUF697; pfam05128
240292003682	L-asparaginase II; Region: Asparaginase_II; cl01842
240292003683	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
240292003684	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
240292003685	putative glycosyl transferase; Provisional; Region: PRK10307
240292003686	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
240292003687	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
240292003688	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
240292003689	Walker A/P-loop; other site
240292003690	ATP binding site [chemical binding]; other site
240292003691	Q-loop/lid; other site
240292003692	ABC transporter signature motif; other site
240292003693	Walker B; other site
240292003694	D-loop; other site
240292003695	H-loop/switch region; other site
240292003696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292003697	dimer interface [polypeptide binding]; other site
240292003698	conserved gate region; other site
240292003699	putative PBP binding loops; other site
240292003700	ABC-ATPase subunit interface; other site
240292003701	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
240292003702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292003703	dimer interface [polypeptide binding]; other site
240292003704	conserved gate region; other site
240292003705	putative PBP binding loops; other site
240292003706	ABC-ATPase subunit interface; other site
240292003707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292003708	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
240292003709	substrate binding pocket [chemical binding]; other site
240292003710	membrane-bound complex binding site; other site
240292003711	hinge residues; other site
240292003712	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
240292003713	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
240292003714	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292003715	FeS/SAM binding site; other site
240292003716	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292003717	anti sigma factor interaction site; other site
240292003718	regulatory phosphorylation site [posttranslational modification]; other site
240292003719	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
240292003720	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292003721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292003722	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292003723	putative substrate translocation pore; other site
240292003724	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
240292003725	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
240292003726	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292003727	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
240292003728	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292003729	Uncharacterized conserved protein [Function unknown]; Region: COG4279
240292003730	SWIM zinc finger; Region: SWIM; pfam04434
240292003731	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
240292003732	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
240292003733	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292003734	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003735	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292003736	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
240292003737	active site
240292003738	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240292003739	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240292003740	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292003741	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292003742	catalytic loop [active]
240292003743	iron binding site [ion binding]; other site
240292003744	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
240292003745	Stage II sporulation protein; Region: SpoIID; pfam08486
240292003746	Uncharacterized protein, contains ParB-like nuclease domain [General function prediction only]; Region: COG5119
240292003747	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
240292003748	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
240292003749	dimerization interface [polypeptide binding]; other site
240292003750	DPS ferroxidase diiron center [ion binding]; other site
240292003751	ion pore; other site
240292003752	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
240292003753	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
240292003754	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
240292003755	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292003756	putative active site [active]
240292003757	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292003758	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292003759	active site
240292003760	ATP binding site [chemical binding]; other site
240292003761	substrate binding site [chemical binding]; other site
240292003762	activation loop (A-loop); other site
240292003763	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
240292003764	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
240292003765	G1 box; other site
240292003766	putative GEF interaction site [polypeptide binding]; other site
240292003767	GTP/Mg2+ binding site [chemical binding]; other site
240292003768	Switch I region; other site
240292003769	G2 box; other site
240292003770	G3 box; other site
240292003771	Switch II region; other site
240292003772	G4 box; other site
240292003773	G5 box; other site
240292003774	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
240292003775	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
240292003776	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
240292003777	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
240292003778	putative active site [active]
240292003779	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
240292003780	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
240292003781	putative active site [active]
240292003782	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292003783	Ligand Binding Site [chemical binding]; other site
240292003784	Phosphoglycerate kinase; Region: PGK; pfam00162
240292003785	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
240292003786	substrate binding site [chemical binding]; other site
240292003787	hinge regions; other site
240292003788	ADP binding site [chemical binding]; other site
240292003789	catalytic site [active]
240292003790	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
240292003791	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
240292003792	nudix motif; other site
240292003793	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
240292003794	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292003795	substrate binding pocket [chemical binding]; other site
240292003796	membrane-bound complex binding site; other site
240292003797	hinge residues; other site
240292003798	FO synthase subunit 2; Reviewed; Region: PRK07360
240292003799	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292003800	FeS/SAM binding site; other site
240292003801	Predicted membrane protein [Function unknown]; Region: COG5305
240292003802	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
240292003803	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
240292003804	Ligand binding site; other site
240292003805	Putative Catalytic site; other site
240292003806	DXD motif; other site
240292003807	Predicted membrane protein [Function unknown]; Region: COG2246
240292003808	GtrA-like protein; Region: GtrA; pfam04138
240292003809	Predicted membrane protein [Function unknown]; Region: COG5305
240292003810	S-adenosylmethionine synthetase; Validated; Region: PRK05250
240292003811	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
240292003812	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
240292003813	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
240292003814	phosphoribulokinase; Provisional; Region: PRK07429
240292003815	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
240292003816	active site
240292003817	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
240292003818	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
240292003819	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
240292003820	dimerization interface [polypeptide binding]; other site
240292003821	FAD binding pocket [chemical binding]; other site
240292003822	FAD binding motif [chemical binding]; other site
240292003823	catalytic residues [active]
240292003824	NAD binding pocket [chemical binding]; other site
240292003825	phosphate binding motif [ion binding]; other site
240292003826	beta-alpha-beta structure motif; other site
240292003827	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
240292003828	homoserine dehydrogenase; Provisional; Region: PRK06349
240292003829	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
240292003830	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
240292003831	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
240292003832	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
240292003833	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
240292003834	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
240292003835	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
240292003836	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
240292003837	Response regulator receiver domain; Region: Response_reg; pfam00072
240292003838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292003839	active site
240292003840	phosphorylation site [posttranslational modification]
240292003841	intermolecular recognition site; other site
240292003842	dimerization interface [polypeptide binding]; other site
240292003843	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292003844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292003845	dimerization interface [polypeptide binding]; other site
240292003846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292003847	dimer interface [polypeptide binding]; other site
240292003848	phosphorylation site [posttranslational modification]
240292003849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003850	ATP binding site [chemical binding]; other site
240292003851	Mg2+ binding site [ion binding]; other site
240292003852	G-X-G motif; other site
240292003853	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
240292003854	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292003855	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292003856	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
240292003857	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
240292003858	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
240292003859	oligomer interface [polypeptide binding]; other site
240292003860	metal binding site [ion binding]; metal-binding site
240292003861	metal binding site [ion binding]; metal-binding site
240292003862	Cl binding site [ion binding]; other site
240292003863	aspartate ring; other site
240292003864	basic sphincter; other site
240292003865	putative hydrophobic gate; other site
240292003866	periplasmic entrance; other site
240292003867	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
240292003868	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
240292003869	dimerization interface [polypeptide binding]; other site
240292003870	active site
240292003871	metal binding site [ion binding]; metal-binding site
240292003872	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
240292003873	dsRNA binding site [nucleotide binding]; other site
240292003874	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240292003875	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240292003876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292003877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292003878	ATP binding site [chemical binding]; other site
240292003879	Mg2+ binding site [ion binding]; other site
240292003880	G-X-G motif; other site
240292003881	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292003882	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292003883	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292003884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
240292003885	dimerization interface [polypeptide binding]; other site
240292003886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292003887	phosphorylation site [posttranslational modification]
240292003888	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
240292003889	RibD C-terminal domain; Region: RibD_C; cl17279
240292003890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
240292003891	Protein of unknown function, DUF482; Region: DUF482; pfam04339
240292003892	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
240292003893	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
240292003894	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
240292003895	Repair protein; Region: Repair_PSII; pfam04536
240292003896	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240292003897	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292003898	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
240292003899	dimerization interface [polypeptide binding]; other site
240292003900	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
240292003901	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292003902	motif II; other site
240292003903	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292003904	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292003905	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292003906	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292003907	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
240292003908	ChaB; Region: ChaB; cl01887
240292003909	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292003910	HSP70 interaction site [polypeptide binding]; other site
240292003911	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
240292003912	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240292003913	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240292003914	protein binding site [polypeptide binding]; other site
240292003915	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
240292003916	Domain interface; other site
240292003917	Peptide binding site; other site
240292003918	Active site tetrad [active]
240292003919	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
240292003920	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
240292003921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292003922	Walker A motif; other site
240292003923	ATP binding site [chemical binding]; other site
240292003924	Walker B motif; other site
240292003925	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
240292003926	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
240292003927	nucleotide binding site/active site [active]
240292003928	HIT family signature motif; other site
240292003929	catalytic residue [active]
240292003930	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
240292003931	Active_site [active]
240292003932	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292003933	phosphopeptide binding site; other site
240292003934	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292003935	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292003936	phosphopeptide binding site; other site
240292003937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292003938	S-adenosylmethionine binding site [chemical binding]; other site
240292003939	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
240292003940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292003941	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
240292003942	dimerization interface [polypeptide binding]; other site
240292003943	substrate binding pocket [chemical binding]; other site
240292003944	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
240292003945	DHH family; Region: DHH; pfam01368
240292003946	DHHA1 domain; Region: DHHA1; pfam02272
240292003947	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292003948	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292003949	Coenzyme A binding pocket [chemical binding]; other site
240292003950	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
240292003951	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292003952	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292003953	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292003954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292003955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292003956	metal binding site [ion binding]; metal-binding site
240292003957	active site
240292003958	I-site; other site
240292003959	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
240292003960	active site
240292003961	catalytic residues [active]
240292003962	metal binding site [ion binding]; metal-binding site
240292003963	Uncharacterized conserved protein [Function unknown]; Region: COG5634
240292003964	Lamin Tail Domain; Region: LTD; pfam00932
240292003965	PsbP; Region: PsbP; pfam01789
240292003966	Maf-like protein; Region: Maf; pfam02545
240292003967	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
240292003968	active site
240292003969	dimer interface [polypeptide binding]; other site
240292003970	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
240292003971	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
240292003972	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
240292003973	trimer interface [polypeptide binding]; other site
240292003974	active site
240292003975	UDP-GlcNAc binding site [chemical binding]; other site
240292003976	lipid binding site [chemical binding]; lipid-binding site
240292003977	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292003978	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292003979	active site
240292003980	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
240292003981	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292003982	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292003983	active site
240292003984	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292003985	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292003986	active site
240292003987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292003988	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
240292003989	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292003990	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292003991	active site
240292003992	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292003993	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292003994	active site
240292003995	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
240292003996	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
240292003997	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
240292003998	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
240292003999	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292004000	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004001	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004002	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292004003	active site
240292004004	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292004006	active site
240292004007	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
240292004008	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240292004009	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
240292004010	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292004011	Chain length determinant protein; Region: Wzz; pfam02706
240292004012	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
240292004013	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240292004014	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292004015	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004016	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
240292004017	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292004018	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004019	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
240292004020	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
240292004021	NAD binding site [chemical binding]; other site
240292004022	dimerization interface [polypeptide binding]; other site
240292004023	product binding site; other site
240292004024	substrate binding site [chemical binding]; other site
240292004025	zinc binding site [ion binding]; other site
240292004026	catalytic residues [active]
240292004027	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
240292004028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004029	ATP binding site [chemical binding]; other site
240292004030	Mg2+ binding site [ion binding]; other site
240292004031	G-X-G motif; other site
240292004032	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
240292004033	ATP binding site [chemical binding]; other site
240292004034	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
240292004035	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
240292004036	dimerization interface [polypeptide binding]; other site
240292004037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
240292004038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
240292004039	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
240292004040	Predicted membrane protein [Function unknown]; Region: COG2259
240292004041	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398
240292004042	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
240292004043	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292004044	HSP70 interaction site [polypeptide binding]; other site
240292004045	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292004046	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292004047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292004048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292004049	Methyltransferase domain; Region: Methyltransf_24; pfam13578
240292004050	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
240292004051	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240292004052	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292004053	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
240292004054	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
240292004055	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
240292004056	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240292004057	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292004058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292004059	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292004060	S-adenosylmethionine binding site [chemical binding]; other site
240292004061	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
240292004062	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004063	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004064	dimer interface [polypeptide binding]; other site
240292004065	phosphorylation site [posttranslational modification]
240292004066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004067	ATP binding site [chemical binding]; other site
240292004068	Mg2+ binding site [ion binding]; other site
240292004069	G-X-G motif; other site
240292004070	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292004071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292004072	dimer interface [polypeptide binding]; other site
240292004073	conserved gate region; other site
240292004074	putative PBP binding loops; other site
240292004075	ABC-ATPase subunit interface; other site
240292004076	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292004077	NMT1-like family; Region: NMT1_2; pfam13379
240292004078	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
240292004079	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292004080	Walker A/P-loop; other site
240292004081	ATP binding site [chemical binding]; other site
240292004082	Q-loop/lid; other site
240292004083	ABC transporter signature motif; other site
240292004084	Walker B; other site
240292004085	D-loop; other site
240292004086	H-loop/switch region; other site
240292004087	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
240292004088	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
240292004089	transmembrane helices; other site
240292004090	Glucosidase II beta subunit-like; Region: PRKCSH-like; pfam12999
240292004091	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
240292004092	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240292004093	ligand binding site [chemical binding]; other site
240292004094	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
240292004095	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
240292004096	Rab subfamily motif 1 (RabSF1); other site
240292004097	G1 box; other site
240292004098	GTP/Mg2+ binding site [chemical binding]; other site
240292004099	Rab subfamily motif 2 (RabSF2); other site
240292004100	Switch I region; other site
240292004101	G2 box; other site
240292004102	effector interaction site; other site
240292004103	GDI interaction site; other site
240292004104	Rab family motif 1 (RabF1); other site
240292004105	GEF interaction site [polypeptide binding]; other site
240292004106	Rab family motif 2 (RabF2); other site
240292004107	G3 box; other site
240292004108	Switch II region; other site
240292004109	Rab family motif 3 (RabF3); other site
240292004110	Rab family motif 4 (RabF4); other site
240292004111	Rab family motif 5 (RabF5); other site
240292004112	Rab subfamily motif 3 (RabSF3); other site
240292004113	G4 box; other site
240292004114	G5 box; other site
240292004115	Rab subfamily motif 4 (RabSF4); other site
240292004116	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
240292004117	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
240292004118	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
240292004119	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
240292004120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
240292004121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292004122	Coenzyme A binding pocket [chemical binding]; other site
240292004123	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
240292004124	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
240292004125	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240292004126	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292004127	Predicted membrane protein [Function unknown]; Region: COG1808
240292004128	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
240292004129	Fe-S cluster binding site [ion binding]; other site
240292004130	active site
240292004131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004132	binding surface
240292004133	TPR motif; other site
240292004134	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004135	binding surface
240292004136	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004137	TPR motif; other site
240292004138	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004140	binding surface
240292004141	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004142	TPR motif; other site
240292004143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292004145	S-adenosylmethionine binding site [chemical binding]; other site
240292004146	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
240292004147	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292004148	active site
240292004149	metal binding site [ion binding]; metal-binding site
240292004150	Protein of unknown function (DUF561); Region: DUF561; pfam04481
240292004151	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
240292004152	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
240292004153	inhibitor-cofactor binding pocket; inhibition site
240292004154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292004155	catalytic residue [active]
240292004156	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
240292004157	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004159	binding surface
240292004160	TPR motif; other site
240292004161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292004162	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
240292004163	clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698
240292004164	Clp protease ATP binding subunit; Region: clpC; CHL00095
240292004165	Clp amino terminal domain; Region: Clp_N; pfam02861
240292004166	Clp amino terminal domain; Region: Clp_N; pfam02861
240292004167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292004168	Walker A motif; other site
240292004169	ATP binding site [chemical binding]; other site
240292004170	Walker B motif; other site
240292004171	arginine finger; other site
240292004172	UvrB/uvrC motif; Region: UVR; pfam02151
240292004173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292004174	Walker A motif; other site
240292004175	ATP binding site [chemical binding]; other site
240292004176	Walker B motif; other site
240292004177	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240292004178	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
240292004179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292004180	Coenzyme A binding pocket [chemical binding]; other site
240292004181	diaminopimelate decarboxylase; Region: lysA; TIGR01048
240292004182	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
240292004183	active site
240292004184	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240292004185	substrate binding site [chemical binding]; other site
240292004186	catalytic residues [active]
240292004187	dimer interface [polypeptide binding]; other site
240292004188	Uncharacterized conserved protein [Function unknown]; Region: COG1624
240292004189	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
240292004190	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
240292004191	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
240292004192	catalytic residue [active]
240292004193	putative FPP diphosphate  binding site; other site
240292004194	putative FPP binding hydrophobic cleft; other site
240292004195	dimer interface [polypeptide binding]; other site
240292004196	putative IPP diphosphate binding site; other site
240292004197	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
240292004198	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292004199	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
240292004200	HSP70 interaction site [polypeptide binding]; other site
240292004201	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292004202	chaperone protein DnaJ; Provisional; Region: PRK14277
240292004203	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292004204	HSP70 interaction site [polypeptide binding]; other site
240292004205	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240292004206	substrate binding site [polypeptide binding]; other site
240292004207	dimer interface [polypeptide binding]; other site
240292004208	molecular chaperone DnaK; Provisional; Region: PRK13410
240292004209	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
240292004210	nucleotide binding site [chemical binding]; other site
240292004211	NEF interaction site [polypeptide binding]; other site
240292004212	SBD interface [polypeptide binding]; other site
240292004213	M28 Zn-Peptidases; Region: M28_like_1; cd05640
240292004214	Peptidase family M28; Region: Peptidase_M28; pfam04389
240292004215	metal binding site [ion binding]; metal-binding site
240292004216	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292004217	putative active site [active]
240292004218	Predicted membrane protein [Function unknown]; Region: COG3781
240292004219	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
240292004220	active site
240292004221	dimer interface [polypeptide binding]; other site
240292004222	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
240292004223	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
240292004224	active site
240292004225	HIGH motif; other site
240292004226	dimer interface [polypeptide binding]; other site
240292004227	KMSKS motif; other site
240292004228	Transglycosylase; Region: Transgly; pfam00912
240292004229	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
240292004230	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240292004231	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
240292004232	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
240292004233	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292004234	HSP70 interaction site [polypeptide binding]; other site
240292004235	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004236	binding surface
240292004237	TPR motif; other site
240292004238	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
240292004239	Short C-terminal domain; Region: SHOCT; pfam09851
240292004240	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
240292004241	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
240292004242	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240292004243	Catalytic site [active]
240292004244	glucokinase; Provisional; Region: glk; PRK00292
240292004245	glucokinase, proteobacterial type; Region: glk; TIGR00749
240292004246	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
240292004247	catalytic core [active]
240292004248	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
240292004249	L-aspartate oxidase; Provisional; Region: PRK06175
240292004250	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240292004251	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
240292004252	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
240292004253	active site
240292004254	catalytic residues [active]
240292004255	metal binding site [ion binding]; metal-binding site
240292004256	DNA photolyase; Region: DNA_photolyase; pfam00875
240292004257	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
240292004258	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292004259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292004260	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292004261	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
240292004262	classical (c) SDRs; Region: SDR_c; cd05233
240292004263	NAD(P) binding site [chemical binding]; other site
240292004264	active site
240292004265	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
240292004266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292004267	ABC transporter signature motif; other site
240292004268	Walker B; other site
240292004269	D-loop; other site
240292004270	H-loop/switch region; other site
240292004271	Uncharacterized conserved protein [Function unknown]; Region: COG2442
240292004272	Uncharacterized conserved protein [Function unknown]; Region: COG0062
240292004273	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
240292004274	putative substrate binding site [chemical binding]; other site
240292004275	putative ATP binding site [chemical binding]; other site
240292004276	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
240292004277	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
240292004278	dimer interface [polypeptide binding]; other site
240292004279	ADP-ribose binding site [chemical binding]; other site
240292004280	active site
240292004281	nudix motif; other site
240292004282	metal binding site [ion binding]; metal-binding site
240292004283	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
240292004284	catalytic center binding site [active]
240292004285	ATP binding site [chemical binding]; other site
240292004286	Transglycosylase; Region: Transgly; pfam00912
240292004287	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
240292004288	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240292004289	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
240292004290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292004291	ATP binding site [chemical binding]; other site
240292004292	putative Mg++ binding site [ion binding]; other site
240292004293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292004294	nucleotide binding region [chemical binding]; other site
240292004295	ATP-binding site [chemical binding]; other site
240292004296	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
240292004297	Protein of unknown function (DUF790); Region: DUF790; pfam05626
240292004298	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
240292004299	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
240292004300	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
240292004301	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
240292004302	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
240292004303	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240292004304	putative NAD(P) binding site [chemical binding]; other site
240292004305	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292004306	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292004307	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
240292004308	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
240292004309	active site
240292004310	dimer interface [polypeptide binding]; other site
240292004311	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292004312	active site
240292004313	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
240292004314	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
240292004315	Moco binding site; other site
240292004316	metal coordination site [ion binding]; other site
240292004317	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
240292004318	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
240292004319	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292004320	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292004321	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292004322	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240292004323	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240292004324	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
240292004325	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
240292004326	active site
240292004327	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
240292004328	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
240292004329	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
240292004330	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
240292004331	Pantoate-beta-alanine ligase; Region: PanC; cd00560
240292004332	active site
240292004333	ATP-binding site [chemical binding]; other site
240292004334	pantoate-binding site; other site
240292004335	HXXH motif; other site
240292004336	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
240292004337	CMP-binding site; other site
240292004338	The sites determining sugar specificity; other site
240292004339	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
240292004340	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
240292004341	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
240292004342	glutaminase A; Region: Gln_ase; TIGR03814
240292004343	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
240292004344	MltA specific insert domain; Region: MltA; pfam03562
240292004345	3D domain; Region: 3D; pfam06725
240292004346	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
240292004347	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292004348	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240292004349	active site
240292004350	metal binding site [ion binding]; metal-binding site
240292004351	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292004352	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292004353	ligand binding site [chemical binding]; other site
240292004354	flexible hinge region; other site
240292004355	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
240292004356	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
240292004357	active site
240292004358	zinc binding site [ion binding]; other site
240292004359	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292004360	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292004361	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292004362	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
240292004363	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292004364	active site
240292004365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292004366	Coenzyme A binding pocket [chemical binding]; other site
240292004367	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292004368	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240292004369	active site
240292004370	metal binding site [ion binding]; metal-binding site
240292004371	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
240292004372	active site
240292004373	dinuclear metal binding site [ion binding]; other site
240292004374	dimerization interface [polypeptide binding]; other site
240292004375	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
240292004376	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
240292004377	NADP binding site [chemical binding]; other site
240292004378	substrate binding site [chemical binding]; other site
240292004379	active site
240292004380	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292004381	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292004382	catalytic loop [active]
240292004383	iron binding site [ion binding]; other site
240292004384	Staphylococcal nuclease homologues; Region: SNc; smart00318
240292004385	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
240292004386	Catalytic site; other site
240292004387	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
240292004388	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
240292004389	active site
240292004390	dimerization interface [polypeptide binding]; other site
240292004391	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
240292004392	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292004393	HSP70 interaction site [polypeptide binding]; other site
240292004394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004395	binding surface
240292004396	TPR motif; other site
240292004397	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
240292004398	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
240292004399	dimer interface [polypeptide binding]; other site
240292004400	motif 1; other site
240292004401	active site
240292004402	motif 2; other site
240292004403	motif 3; other site
240292004404	Ferredoxin [Energy production and conversion]; Region: COG1146
240292004405	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
240292004406	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
240292004407	Walker A/P-loop; other site
240292004408	ATP binding site [chemical binding]; other site
240292004409	Q-loop/lid; other site
240292004410	ABC transporter signature motif; other site
240292004411	Walker B; other site
240292004412	D-loop; other site
240292004413	H-loop/switch region; other site
240292004414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292004415	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
240292004416	Ion channel; Region: Ion_trans_2; pfam07885
240292004417	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292004418	membrane-bound complex binding site; other site
240292004419	hinge residues; other site
240292004420	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
240292004421	active site clefts [active]
240292004422	zinc binding site [ion binding]; other site
240292004423	dimer interface [polypeptide binding]; other site
240292004424	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
240292004425	active site clefts [active]
240292004426	zinc binding site [ion binding]; other site
240292004427	dimer interface [polypeptide binding]; other site
240292004428	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
240292004429	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292004430	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292004431	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
240292004432	MPN+ (JAMM) motif; other site
240292004433	Zinc-binding site [ion binding]; other site
240292004434	hypothetical protein; Validated; Region: PRK07411
240292004435	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
240292004436	ATP binding site [chemical binding]; other site
240292004437	substrate interface [chemical binding]; other site
240292004438	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240292004439	active site residue [active]
240292004440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
240292004441	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292004442	HEAT repeats; Region: HEAT_2; pfam13646
240292004443	HEAT repeats; Region: HEAT_2; pfam13646
240292004444	HEAT repeats; Region: HEAT_2; pfam13646
240292004445	Transposase domain (DUF772); Region: DUF772; pfam05598
240292004446	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292004447	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292004448	putative active site [active]
240292004449	metabolite-proton symporter; Region: 2A0106; TIGR00883
240292004450	NADH(P)-binding; Region: NAD_binding_10; pfam13460
240292004451	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
240292004452	NAD(P) binding site [chemical binding]; other site
240292004453	putative active site [active]
240292004454	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
240292004455	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
240292004456	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
240292004457	GAF domain; Region: GAF; pfam01590
240292004458	Phytochrome region; Region: PHY; pfam00360
240292004459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004460	dimer interface [polypeptide binding]; other site
240292004461	phosphorylation site [posttranslational modification]
240292004462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004463	ATP binding site [chemical binding]; other site
240292004464	Mg2+ binding site [ion binding]; other site
240292004465	G-X-G motif; other site
240292004466	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004468	active site
240292004469	phosphorylation site [posttranslational modification]
240292004470	intermolecular recognition site; other site
240292004471	dimerization interface [polypeptide binding]; other site
240292004472	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292004473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004474	active site
240292004475	phosphorylation site [posttranslational modification]
240292004476	intermolecular recognition site; other site
240292004477	dimerization interface [polypeptide binding]; other site
240292004478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004479	PAS fold; Region: PAS_3; pfam08447
240292004480	putative active site [active]
240292004481	heme pocket [chemical binding]; other site
240292004482	PAS fold; Region: PAS_3; pfam08447
240292004483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004484	putative active site [active]
240292004485	heme pocket [chemical binding]; other site
240292004486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004488	dimer interface [polypeptide binding]; other site
240292004489	phosphorylation site [posttranslational modification]
240292004490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004491	ATP binding site [chemical binding]; other site
240292004492	Mg2+ binding site [ion binding]; other site
240292004493	G-X-G motif; other site
240292004494	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
240292004495	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
240292004496	substrate binding site [chemical binding]; other site
240292004497	glutamase interaction surface [polypeptide binding]; other site
240292004498	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
240292004499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292004500	Walker A motif; other site
240292004501	ATP binding site [chemical binding]; other site
240292004502	Walker B motif; other site
240292004503	arginine finger; other site
240292004504	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
240292004505	TPR repeat; Region: TPR_11; pfam13414
240292004506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004507	binding surface
240292004508	TPR motif; other site
240292004509	TPR repeat; Region: TPR_11; pfam13414
240292004510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004511	binding surface
240292004512	TPR motif; other site
240292004513	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
240292004514	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
240292004515	classical (c) SDRs; Region: SDR_c; cd05233
240292004516	NAD(P) binding site [chemical binding]; other site
240292004517	active site
240292004518	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
240292004519	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292004520	RNA binding surface [nucleotide binding]; other site
240292004521	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240292004522	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
240292004523	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
240292004524	Walker A motif; other site
240292004525	ATP binding site [chemical binding]; other site
240292004526	Walker B motif; other site
240292004527	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240292004528	ATP binding site [chemical binding]; other site
240292004529	Walker B motif; other site
240292004530	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
240292004531	tetramer interface [polypeptide binding]; other site
240292004532	dimer interface [polypeptide binding]; other site
240292004533	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292004534	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292004535	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292004536	KaiA domain; Region: KaiA; pfam07688
240292004537	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004539	dimer interface [polypeptide binding]; other site
240292004540	phosphorylation site [posttranslational modification]
240292004541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004542	ATP binding site [chemical binding]; other site
240292004543	Mg2+ binding site [ion binding]; other site
240292004544	G-X-G motif; other site
240292004545	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004547	active site
240292004548	phosphorylation site [posttranslational modification]
240292004549	intermolecular recognition site; other site
240292004550	dimerization interface [polypeptide binding]; other site
240292004551	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
240292004552	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
240292004553	putative lipid kinase; Reviewed; Region: PRK13057
240292004554	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292004555	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
240292004556	Walker A/P-loop; other site
240292004557	ATP binding site [chemical binding]; other site
240292004558	Q-loop/lid; other site
240292004559	ABC transporter signature motif; other site
240292004560	Walker B; other site
240292004561	D-loop; other site
240292004562	H-loop/switch region; other site
240292004563	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292004564	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
240292004565	Walker A/P-loop; other site
240292004566	ATP binding site [chemical binding]; other site
240292004567	Q-loop/lid; other site
240292004568	ABC transporter signature motif; other site
240292004569	Walker B; other site
240292004570	D-loop; other site
240292004571	H-loop/switch region; other site
240292004572	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292004573	NMT1-like family; Region: NMT1_2; pfam13379
240292004574	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292004575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292004576	dimer interface [polypeptide binding]; other site
240292004577	conserved gate region; other site
240292004578	putative PBP binding loops; other site
240292004579	ABC-ATPase subunit interface; other site
240292004580	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292004581	NMT1-like family; Region: NMT1_2; pfam13379
240292004582	Uncharacterized conserved protein [Function unknown]; Region: COG0397
240292004583	hypothetical protein; Validated; Region: PRK00029
240292004584	CHASE domain; Region: CHASE; cl01369
240292004585	PAS domain S-box; Region: sensory_box; TIGR00229
240292004586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004587	putative active site [active]
240292004588	heme pocket [chemical binding]; other site
240292004589	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004590	PAS domain; Region: PAS_9; pfam13426
240292004591	putative active site [active]
240292004592	heme pocket [chemical binding]; other site
240292004593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004594	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292004595	putative active site [active]
240292004596	heme pocket [chemical binding]; other site
240292004597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004598	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292004599	putative active site [active]
240292004600	heme pocket [chemical binding]; other site
240292004601	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004602	heme pocket [chemical binding]; other site
240292004603	putative active site [active]
240292004604	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292004605	GAF domain; Region: GAF; pfam01590
240292004606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004608	dimer interface [polypeptide binding]; other site
240292004609	phosphorylation site [posttranslational modification]
240292004610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004611	ATP binding site [chemical binding]; other site
240292004612	Mg2+ binding site [ion binding]; other site
240292004613	G-X-G motif; other site
240292004614	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004616	active site
240292004617	phosphorylation site [posttranslational modification]
240292004618	intermolecular recognition site; other site
240292004619	dimerization interface [polypeptide binding]; other site
240292004620	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004622	active site
240292004623	phosphorylation site [posttranslational modification]
240292004624	intermolecular recognition site; other site
240292004625	dimerization interface [polypeptide binding]; other site
240292004626	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292004627	putative binding surface; other site
240292004628	active site
240292004629	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004631	active site
240292004632	phosphorylation site [posttranslational modification]
240292004633	intermolecular recognition site; other site
240292004634	dimerization interface [polypeptide binding]; other site
240292004635	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292004636	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292004637	metal binding site [ion binding]; metal-binding site
240292004638	active site
240292004639	I-site; other site
240292004640	Predicted kinase [General function prediction only]; Region: COG4240
240292004641	active site
240292004642	Protein of unknown function (DUF565); Region: DUF565; pfam04483
240292004643	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292004644	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240292004645	Uncharacterized conserved protein [Function unknown]; Region: COG1434
240292004646	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240292004647	putative active site [active]
240292004648	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004649	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
240292004650	Ligand binding site; other site
240292004651	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004652	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
240292004653	metal-binding site
240292004654	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004655	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
240292004656	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
240292004657	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
240292004658	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
240292004659	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
240292004660	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292004661	Chain length determinant protein; Region: Wzz; pfam02706
240292004662	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
240292004663	Chain length determinant protein; Region: Wzz; cl15801
240292004664	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240292004665	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292004666	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
240292004667	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292004668	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
240292004669	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
240292004670	NAD binding site [chemical binding]; other site
240292004671	homodimer interface [polypeptide binding]; other site
240292004672	active site
240292004673	substrate binding site [chemical binding]; other site
240292004674	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
240292004675	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292004676	active site
240292004677	metal binding site [ion binding]; metal-binding site
240292004678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
240292004679	FIST N domain; Region: FIST; pfam08495
240292004680	FIST C domain; Region: FIST_C; pfam10442
240292004681	CP12 domain; Region: CP12; pfam02672
240292004682	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
240292004683	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
240292004684	GMP synthase; Reviewed; Region: guaA; PRK00074
240292004685	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
240292004686	AMP/PPi binding site [chemical binding]; other site
240292004687	candidate oxyanion hole; other site
240292004688	catalytic triad [active]
240292004689	potential glutamine specificity residues [chemical binding]; other site
240292004690	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
240292004691	ATP Binding subdomain [chemical binding]; other site
240292004692	Ligand Binding sites [chemical binding]; other site
240292004693	Dimerization subdomain; other site
240292004694	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
240292004695	diiron binding motif [ion binding]; other site
240292004696	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
240292004697	Pheophorbide a oxygenase; Region: PaO; pfam08417
240292004698	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240292004699	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
240292004700	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
240292004701	metal binding site [ion binding]; metal-binding site
240292004702	dimer interface [polypeptide binding]; other site
240292004703	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292004704	putative active site [active]
240292004705	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
240292004706	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
240292004707	B12 binding site [chemical binding]; other site
240292004708	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292004709	FeS/SAM binding site; other site
240292004710	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
240292004711	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
240292004712	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240292004713	Predicted transcriptional regulators [Transcription]; Region: COG1733
240292004714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292004715	dimerization interface [polypeptide binding]; other site
240292004716	putative DNA binding site [nucleotide binding]; other site
240292004717	putative Zn2+ binding site [ion binding]; other site
240292004718	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
240292004719	metal ion-dependent adhesion site (MIDAS); other site
240292004720	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
240292004721	metal ion-dependent adhesion site (MIDAS); other site
240292004722	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292004723	TrkA-N domain; Region: TrkA_N; pfam02254
240292004724	TrkA-C domain; Region: TrkA_C; pfam02080
240292004725	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
240292004726	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
240292004727	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
240292004728	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
240292004729	Peptidase family M50; Region: Peptidase_M50; pfam02163
240292004730	active site
240292004731	putative substrate binding region [chemical binding]; other site
240292004732	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292004733	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292004734	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292004735	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292004736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292004737	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
240292004738	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
240292004739	G1 box; other site
240292004740	GTP/Mg2+ binding site [chemical binding]; other site
240292004741	Switch I region; other site
240292004742	G2 box; other site
240292004743	G3 box; other site
240292004744	Switch II region; other site
240292004745	G4 box; other site
240292004746	G5 box; other site
240292004747	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
240292004748	Nucleoside recognition; Region: Gate; pfam07670
240292004749	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
240292004750	Nucleoside recognition; Region: Gate; pfam07670
240292004751	FeoA domain; Region: FeoA; pfam04023
240292004752	tocopherol O-methyltransferase; Region: PLN02244
240292004753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292004754	S-adenosylmethionine binding site [chemical binding]; other site
240292004755	Predicted membrane protein [Function unknown]; Region: COG2149
240292004756	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
240292004757	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
240292004758	dimer interface [polypeptide binding]; other site
240292004759	PYR/PP interface [polypeptide binding]; other site
240292004760	TPP binding site [chemical binding]; other site
240292004761	substrate binding site [chemical binding]; other site
240292004762	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
240292004763	Domain of unknown function; Region: EKR; smart00890
240292004764	4Fe-4S binding domain; Region: Fer4_6; pfam12837
240292004765	4Fe-4S binding domain; Region: Fer4; pfam00037
240292004766	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
240292004767	TPP-binding site [chemical binding]; other site
240292004768	dimer interface [polypeptide binding]; other site
240292004769	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
240292004770	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
240292004771	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
240292004772	putative homodimer interface [polypeptide binding]; other site
240292004773	putative active site pocket [active]
240292004774	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
240292004775	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292004776	GAF domain; Region: GAF_3; pfam13492
240292004777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004779	dimer interface [polypeptide binding]; other site
240292004780	phosphorylation site [posttranslational modification]
240292004781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004782	ATP binding site [chemical binding]; other site
240292004783	Mg2+ binding site [ion binding]; other site
240292004784	G-X-G motif; other site
240292004785	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004787	active site
240292004788	phosphorylation site [posttranslational modification]
240292004789	intermolecular recognition site; other site
240292004790	dimerization interface [polypeptide binding]; other site
240292004791	PAS fold; Region: PAS_4; pfam08448
240292004792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004793	putative active site [active]
240292004794	heme pocket [chemical binding]; other site
240292004795	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292004796	GAF domain; Region: GAF; cl17456
240292004797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292004798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292004799	dimer interface [polypeptide binding]; other site
240292004800	phosphorylation site [posttranslational modification]
240292004801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292004802	ATP binding site [chemical binding]; other site
240292004803	Mg2+ binding site [ion binding]; other site
240292004804	G-X-G motif; other site
240292004805	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292004806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004807	active site
240292004808	phosphorylation site [posttranslational modification]
240292004809	intermolecular recognition site; other site
240292004810	dimerization interface [polypeptide binding]; other site
240292004811	S-formylglutathione hydrolase; Region: PLN02442
240292004812	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
240292004813	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292004814	putative active site [active]
240292004815	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
240292004816	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
240292004817	substrate binding site [chemical binding]; other site
240292004818	catalytic Zn binding site [ion binding]; other site
240292004819	NAD binding site [chemical binding]; other site
240292004820	structural Zn binding site [ion binding]; other site
240292004821	dimer interface [polypeptide binding]; other site
240292004822	Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977
240292004823	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292004824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292004825	homodimer interface [polypeptide binding]; other site
240292004826	catalytic residue [active]
240292004827	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
240292004828	RimM N-terminal domain; Region: RimM; pfam01782
240292004829	PRC-barrel domain; Region: PRC; pfam05239
240292004830	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292004831	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292004832	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
240292004833	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
240292004834	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
240292004835	Protein of unknown function, DUF608; Region: DUF608; pfam04685
240292004836	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292004837	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292004838	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
240292004839	putative active site [active]
240292004840	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292004841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292004842	Walker A/P-loop; other site
240292004843	ATP binding site [chemical binding]; other site
240292004844	Q-loop/lid; other site
240292004845	ABC transporter signature motif; other site
240292004846	Walker B; other site
240292004847	D-loop; other site
240292004848	H-loop/switch region; other site
240292004849	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
240292004850	Response regulator receiver domain; Region: Response_reg; pfam00072
240292004851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292004852	active site
240292004853	phosphorylation site [posttranslational modification]
240292004854	intermolecular recognition site; other site
240292004855	dimerization interface [polypeptide binding]; other site
240292004856	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
240292004857	metal ion-dependent adhesion site (MIDAS); other site
240292004858	Protein phosphatase 2C; Region: PP2C_2; pfam13672
240292004859	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
240292004860	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240292004861	substrate binding site [chemical binding]; other site
240292004862	activation loop (A-loop); other site
240292004863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004864	binding surface
240292004865	TPR repeat; Region: TPR_11; pfam13414
240292004866	TPR motif; other site
240292004867	TPR repeat; Region: TPR_11; pfam13414
240292004868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292004869	TPR motif; other site
240292004870	TPR repeat; Region: TPR_11; pfam13414
240292004871	binding surface
240292004872	TPR repeat; Region: TPR_11; pfam13414
240292004873	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
240292004874	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
240292004875	substrate binding site; other site
240292004876	Predicted dehydrogenase [General function prediction only]; Region: COG0579
240292004877	hydroxyglutarate oxidase; Provisional; Region: PRK11728
240292004878	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
240292004879	extended (e) SDRs; Region: SDR_e; cd08946
240292004880	NAD(P) binding site [chemical binding]; other site
240292004881	active site
240292004882	substrate binding site [chemical binding]; other site
240292004883	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004884	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292004885	active site
240292004886	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
240292004887	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004888	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
240292004889	active site
240292004890	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
240292004891	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
240292004892	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240292004893	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
240292004894	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004895	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
240292004896	putative ADP-binding pocket [chemical binding]; other site
240292004897	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292004898	Chain length determinant protein; Region: Wzz; cl15801
240292004899	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240292004900	Bacterial sugar transferase; Region: Bac_transf; cl00939
240292004901	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292004902	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292004903	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240292004904	Walker A/P-loop; other site
240292004905	ATP binding site [chemical binding]; other site
240292004906	Q-loop/lid; other site
240292004907	ABC transporter signature motif; other site
240292004908	Walker B; other site
240292004909	D-loop; other site
240292004910	H-loop/switch region; other site
240292004911	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292004912	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292004913	active site
240292004914	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292004915	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292004916	active site
240292004917	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292004918	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292004919	active site
240292004920	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004921	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292004922	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292004923	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292004924	active site
240292004925	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292004926	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
240292004927	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
240292004928	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
240292004929	metal-binding site [ion binding]
240292004930	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292004931	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292004932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292004933	putative DNA binding site [nucleotide binding]; other site
240292004934	dimerization interface [polypeptide binding]; other site
240292004935	putative Zn2+ binding site [ion binding]; other site
240292004936	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
240292004937	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292004938	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292004939	Walker A/P-loop; other site
240292004940	ATP binding site [chemical binding]; other site
240292004941	Q-loop/lid; other site
240292004942	ABC transporter signature motif; other site
240292004943	Walker B; other site
240292004944	D-loop; other site
240292004945	H-loop/switch region; other site
240292004946	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
240292004947	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
240292004948	putative active site [active]
240292004949	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292004950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292004951	Walker A/P-loop; other site
240292004952	ATP binding site [chemical binding]; other site
240292004953	Q-loop/lid; other site
240292004954	ABC transporter signature motif; other site
240292004955	Walker B; other site
240292004956	D-loop; other site
240292004957	H-loop/switch region; other site
240292004958	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
240292004959	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292004960	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292004961	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
240292004962	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
240292004963	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
240292004964	B12 binding site [chemical binding]; other site
240292004965	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292004966	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
240292004967	ligand binding site [chemical binding]; other site
240292004968	flexible hinge region; other site
240292004969	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292004970	ligand binding site [chemical binding]; other site
240292004971	flexible hinge region; other site
240292004972	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
240292004973	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292004974	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292004975	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
240292004976	Cache domain; Region: Cache_1; pfam02743
240292004977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292004978	dimerization interface [polypeptide binding]; other site
240292004979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292004980	PAS domain; Region: PAS_9; pfam13426
240292004981	putative active site [active]
240292004982	heme pocket [chemical binding]; other site
240292004983	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292004984	Helix-turn-helix domain; Region: HTH_18; pfam12833
240292004985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292004986	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292004987	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292004988	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240292004989	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
240292004990	putative heme binding site [chemical binding]; other site
240292004991	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
240292004992	Phosphotransferase enzyme family; Region: APH; pfam01636
240292004993	active site
240292004994	substrate binding site [chemical binding]; other site
240292004995	ATP binding site [chemical binding]; other site
240292004996	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
240292004997	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
240292004998	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292004999	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
240292005000	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240292005001	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292005002	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292005003	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
240292005004	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
240292005005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292005006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292005007	dimer interface [polypeptide binding]; other site
240292005008	phosphorylation site [posttranslational modification]
240292005009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292005010	ATP binding site [chemical binding]; other site
240292005011	Mg2+ binding site [ion binding]; other site
240292005012	G-X-G motif; other site
240292005013	Homeodomain-like domain; Region: HTH_23; pfam13384
240292005014	Winged helix-turn helix; Region: HTH_29; pfam13551
240292005015	Homeodomain-like domain; Region: HTH_32; pfam13565
240292005016	Integrase core domain; Region: rve; pfam00665
240292005017	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292005018	Bacterial TniB protein; Region: TniB; pfam05621
240292005019	AAA domain; Region: AAA_22; pfam13401
240292005020	TniQ; Region: TniQ; pfam06527
240292005021	Protein kinase domain; Region: Pkinase; pfam00069
240292005022	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292005023	active site
240292005024	ATP binding site [chemical binding]; other site
240292005025	substrate binding site [chemical binding]; other site
240292005026	activation loop (A-loop); other site
240292005027	Protein of unknown function DUF45; Region: DUF45; cl00636
240292005028	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
240292005029	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
240292005030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292005031	ATP binding site [chemical binding]; other site
240292005032	putative Mg++ binding site [ion binding]; other site
240292005033	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
240292005034	Divergent AAA domain; Region: AAA_4; pfam04326
240292005035	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
240292005036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
240292005037	putative DNA binding site [nucleotide binding]; other site
240292005038	putative Zn2+ binding site [ion binding]; other site
240292005039	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292005040	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
240292005041	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292005042	HsdM N-terminal domain; Region: HsdM_N; pfam12161
240292005043	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
240292005044	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
240292005045	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
240292005046	DNA binding residues [nucleotide binding]
240292005047	putative dimer interface [polypeptide binding]; other site
240292005048	lipoyl synthase; Provisional; Region: PRK05481
240292005049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292005050	FeS/SAM binding site; other site
240292005051	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
240292005052	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
240292005053	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
240292005054	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
240292005055	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292005056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292005057	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292005058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292005059	DNA binding residues [nucleotide binding]
240292005060	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
240292005061	metal binding site 2 [ion binding]; metal-binding site
240292005062	putative DNA binding helix; other site
240292005063	metal binding site 1 [ion binding]; metal-binding site
240292005064	dimer interface [polypeptide binding]; other site
240292005065	structural Zn2+ binding site [ion binding]; other site
240292005066	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005067	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292005068	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005069	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005070	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005071	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
240292005072	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
240292005073	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
240292005074	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005075	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292005076	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292005077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292005078	dimer interface [polypeptide binding]; other site
240292005079	phosphorylation site [posttranslational modification]
240292005080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292005081	ATP binding site [chemical binding]; other site
240292005082	Mg2+ binding site [ion binding]; other site
240292005083	G-X-G motif; other site
240292005084	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
240292005085	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292005086	active site
240292005087	metal binding site [ion binding]; metal-binding site
240292005088	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
240292005089	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292005090	catalytic residue [active]
240292005091	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
240292005092	MgtE intracellular N domain; Region: MgtE_N; smart00924
240292005093	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
240292005094	Divalent cation transporter; Region: MgtE; pfam01769
240292005095	Homeodomain-like domain; Region: HTH_23; pfam13384
240292005096	Winged helix-turn helix; Region: HTH_29; pfam13551
240292005097	Winged helix-turn helix; Region: HTH_33; pfam13592
240292005098	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292005099	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
240292005100	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
240292005101	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
240292005102	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292005103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292005104	ATP binding site [chemical binding]; other site
240292005105	Mg2+ binding site [ion binding]; other site
240292005106	G-X-G motif; other site
240292005107	Predicted membrane protein [Function unknown]; Region: COG4327
240292005108	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
240292005109	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
240292005110	Na binding site [ion binding]; other site
240292005111	TPR repeat; Region: TPR_11; pfam13414
240292005112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005113	binding surface
240292005114	TPR motif; other site
240292005115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005116	binding surface
240292005117	TPR motif; other site
240292005118	TPR repeat; Region: TPR_11; pfam13414
240292005119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005120	binding surface
240292005121	TPR motif; other site
240292005122	TPR repeat; Region: TPR_11; pfam13414
240292005123	methionine sulfoxide reductase A; Provisional; Region: PRK00058
240292005124	proton extrusion protein PcxA; Provisional; Region: PRK02507
240292005125	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240292005126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292005127	non-specific DNA binding site [nucleotide binding]; other site
240292005128	salt bridge; other site
240292005129	sequence-specific DNA binding site [nucleotide binding]; other site
240292005130	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240292005131	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
240292005132	NodB motif; other site
240292005133	active site
240292005134	catalytic site [active]
240292005135	metal binding site [ion binding]; metal-binding site
240292005136	putative glycosyl transferase; Provisional; Region: PRK10307
240292005137	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
240292005138	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292005139	ligand binding site [chemical binding]; other site
240292005140	flexible hinge region; other site
240292005141	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292005142	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
240292005143	putative active site [active]
240292005144	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292005145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292005146	Walker A/P-loop; other site
240292005147	ATP binding site [chemical binding]; other site
240292005148	Q-loop/lid; other site
240292005149	ABC transporter signature motif; other site
240292005150	Walker B; other site
240292005151	D-loop; other site
240292005152	H-loop/switch region; other site
240292005153	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
240292005154	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
240292005155	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292005156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
240292005157	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
240292005158	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
240292005159	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
240292005160	Ligand Binding Site [chemical binding]; other site
240292005161	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
240292005162	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
240292005163	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
240292005164	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292005165	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292005166	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
240292005167	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292005168	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
240292005169	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292005170	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
240292005171	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292005172	ATP binding site [chemical binding]; other site
240292005173	putative Mg++ binding site [ion binding]; other site
240292005174	helicase superfamily c-terminal domain; Region: HELICc; smart00490
240292005175	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292005176	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
240292005177	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292005178	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292005179	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292005180	DNA binding residues [nucleotide binding]
240292005181	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292005182	Coenzyme A binding pocket [chemical binding]; other site
240292005183	cytochrome c6; Provisional; Region: PRK13697
240292005184	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240292005185	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240292005186	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240292005187	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
240292005188	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
240292005189	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
240292005190	NAD(P) binding site [chemical binding]; other site
240292005191	Homeodomain-like domain; Region: HTH_23; pfam13384
240292005192	Winged helix-turn helix; Region: HTH_29; pfam13551
240292005193	Winged helix-turn helix; Region: HTH_33; pfam13592
240292005194	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292005195	acetyl-CoA synthetase; Provisional; Region: PRK00174
240292005196	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
240292005197	active site
240292005198	CoA binding site [chemical binding]; other site
240292005199	acyl-activating enzyme (AAE) consensus motif; other site
240292005200	AMP binding site [chemical binding]; other site
240292005201	acetate binding site [chemical binding]; other site
240292005202	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005203	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292005204	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005205	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292005206	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005207	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292005208	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005209	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292005210	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292005211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292005212	dimer interface [polypeptide binding]; other site
240292005213	phosphorylation site [posttranslational modification]
240292005214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292005215	ATP binding site [chemical binding]; other site
240292005216	Mg2+ binding site [ion binding]; other site
240292005217	G-X-G motif; other site
240292005218	PetN; Region: PetN; pfam03742
240292005219	MgtC family; Region: MgtC; pfam02308
240292005220	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
240292005221	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240292005222	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
240292005223	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240292005224	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240292005225	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
240292005226	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
240292005227	putative NADP binding site [chemical binding]; other site
240292005228	putative substrate binding site [chemical binding]; other site
240292005229	active site
240292005230	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
240292005231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292005232	FeS/SAM binding site; other site
240292005233	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
240292005234	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
240292005235	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292005236	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
240292005237	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
240292005238	quinone interaction residues [chemical binding]; other site
240292005239	active site
240292005240	catalytic residues [active]
240292005241	FMN binding site [chemical binding]; other site
240292005242	substrate binding site [chemical binding]; other site
240292005243	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292005244	GAF domain; Region: GAF; pfam01590
240292005245	Uncharacterized conserved protein; Region: KxDL; pfam10241
240292005246	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
240292005247	Predicted transcriptional regulators [Transcription]; Region: COG1695
240292005248	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
240292005249	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
240292005250	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292005251	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292005252	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292005253	hypothetical protein; Validated; Region: PRK00110
240292005254	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
240292005255	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292005256	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240292005257	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
240292005258	putative active site [active]
240292005259	putative metal binding site [ion binding]; other site
240292005260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292005261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292005262	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292005263	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292005264	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292005265	DevC protein; Region: devC; TIGR01185
240292005266	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292005267	FtsX-like permease family; Region: FtsX; pfam02687
240292005268	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292005269	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292005270	Walker A/P-loop; other site
240292005271	ATP binding site [chemical binding]; other site
240292005272	Q-loop/lid; other site
240292005273	ABC transporter signature motif; other site
240292005274	Walker B; other site
240292005275	D-loop; other site
240292005276	H-loop/switch region; other site
240292005277	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
240292005278	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
240292005279	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
240292005280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292005281	BT1 family; Region: BT1; pfam03092
240292005282	putative substrate translocation pore; other site
240292005283	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
240292005284	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
240292005285	dimer interface [polypeptide binding]; other site
240292005286	active site
240292005287	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292005288	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
240292005289	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
240292005290	active site
240292005291	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
240292005292	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
240292005293	D1 interface; other site
240292005294	chlorophyll binding site; other site
240292005295	pheophytin binding site; other site
240292005296	beta carotene binding site; other site
240292005297	cytochrome b559 beta interface; other site
240292005298	quinone binding site; other site
240292005299	cytochrome b559 alpha interface; other site
240292005300	protein J interface; other site
240292005301	protein H interface; other site
240292005302	protein X interface; other site
240292005303	core light harvesting protein interface; other site
240292005304	protein L interface; other site
240292005305	CP43 interface; other site
240292005306	protein T interface; other site
240292005307	Fe binding site [ion binding]; other site
240292005308	protein M interface; other site
240292005309	Mn-stabilizing polypeptide interface; other site
240292005310	bromide binding site; other site
240292005311	cytochrome c-550 interface; other site
240292005312	photosystem II 44 kDa protein; Region: psbC; CHL00035
240292005313	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
240292005314	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
240292005315	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005316	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292005317	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005318	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005319	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292005320	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005321	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292005322	Ycf46; Provisional; Region: ycf46; CHL00195
240292005323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292005324	Walker A motif; other site
240292005325	ATP binding site [chemical binding]; other site
240292005326	Walker B motif; other site
240292005327	arginine finger; other site
240292005328	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
240292005329	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
240292005330	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292005331	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292005332	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292005333	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292005334	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292005335	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
240292005336	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240292005337	Zn2+ binding site [ion binding]; other site
240292005338	Mg2+ binding site [ion binding]; other site
240292005339	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
240292005340	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
240292005341	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
240292005342	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292005343	FeS/SAM binding site; other site
240292005344	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
240292005345	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
240292005346	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240292005347	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292005348	Walker A/P-loop; other site
240292005349	ATP binding site [chemical binding]; other site
240292005350	Q-loop/lid; other site
240292005351	ABC transporter signature motif; other site
240292005352	Walker B; other site
240292005353	D-loop; other site
240292005354	H-loop/switch region; other site
240292005355	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292005356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292005357	active site
240292005358	phosphorylation site [posttranslational modification]
240292005359	intermolecular recognition site; other site
240292005360	dimerization interface [polypeptide binding]; other site
240292005361	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292005362	DNA binding site [nucleotide binding]
240292005363	Predicted membrane protein [Function unknown]; Region: COG3650
240292005364	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
240292005365	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
240292005366	active site
240292005367	non-prolyl cis peptide bond; other site
240292005368	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
240292005369	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
240292005370	Mg++ binding site [ion binding]; other site
240292005371	putative catalytic motif [active]
240292005372	putative substrate binding site [chemical binding]; other site
240292005373	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
240292005374	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
240292005375	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
240292005376	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
240292005377	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
240292005378	DNA binding site [nucleotide binding]
240292005379	catalytic residue [active]
240292005380	H2TH interface [polypeptide binding]; other site
240292005381	putative catalytic residues [active]
240292005382	turnover-facilitating residue; other site
240292005383	intercalation triad [nucleotide binding]; other site
240292005384	8OG recognition residue [nucleotide binding]; other site
240292005385	putative reading head residues; other site
240292005386	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
240292005387	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
240292005388	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
240292005389	malate dehydrogenase; Reviewed; Region: PRK06223
240292005390	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
240292005391	NAD(P) binding site [chemical binding]; other site
240292005392	dimer interface [polypeptide binding]; other site
240292005393	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240292005394	substrate binding site [chemical binding]; other site
240292005395	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
240292005396	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
240292005397	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292005398	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292005399	homodimer interface [polypeptide binding]; other site
240292005400	catalytic residue [active]
240292005401	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292005402	anti sigma factor interaction site; other site
240292005403	regulatory phosphorylation site [posttranslational modification]; other site
240292005404	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
240292005405	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292005406	FeS/SAM binding site; other site
240292005407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011
240292005408	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
240292005409	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
240292005410	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
240292005411	homodimer interface [polypeptide binding]; other site
240292005412	oligonucleotide binding site [chemical binding]; other site
240292005413	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
240292005414	RNA/DNA hybrid binding site [nucleotide binding]; other site
240292005415	active site
240292005416	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
240292005417	prephenate dehydratase; Provisional; Region: PRK11898
240292005418	Prephenate dehydratase; Region: PDT; pfam00800
240292005419	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
240292005420	putative L-Phe binding site [chemical binding]; other site
240292005421	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
240292005422	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
240292005423	elongation factor Tu; Region: tufA; CHL00071
240292005424	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
240292005425	G1 box; other site
240292005426	GEF interaction site [polypeptide binding]; other site
240292005427	GTP/Mg2+ binding site [chemical binding]; other site
240292005428	Switch I region; other site
240292005429	G2 box; other site
240292005430	G3 box; other site
240292005431	Switch II region; other site
240292005432	G4 box; other site
240292005433	G5 box; other site
240292005434	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
240292005435	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
240292005436	Antibiotic Binding Site [chemical binding]; other site
240292005437	elongation factor G; Reviewed; Region: PRK00007
240292005438	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
240292005439	G1 box; other site
240292005440	putative GEF interaction site [polypeptide binding]; other site
240292005441	GTP/Mg2+ binding site [chemical binding]; other site
240292005442	Switch I region; other site
240292005443	G2 box; other site
240292005444	G3 box; other site
240292005445	Switch II region; other site
240292005446	G4 box; other site
240292005447	G5 box; other site
240292005448	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
240292005449	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
240292005450	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
240292005451	30S ribosomal protein S7; Validated; Region: PRK05302
240292005452	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
240292005453	S17 interaction site [polypeptide binding]; other site
240292005454	S8 interaction site; other site
240292005455	16S rRNA interaction site [nucleotide binding]; other site
240292005456	streptomycin interaction site [chemical binding]; other site
240292005457	23S rRNA interaction site [nucleotide binding]; other site
240292005458	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
240292005459	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
240292005460	Cupin domain; Region: Cupin_2; cl17218
240292005461	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
240292005462	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
240292005463	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
240292005464	active site
240292005465	dimer interface [polypeptide binding]; other site
240292005466	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
240292005467	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
240292005468	active site
240292005469	FMN binding site [chemical binding]; other site
240292005470	substrate binding site [chemical binding]; other site
240292005471	3Fe-4S cluster binding site [ion binding]; other site
240292005472	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
240292005473	domain interface; other site
240292005474	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240292005475	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
240292005476	NodB motif; other site
240292005477	active site
240292005478	catalytic site [active]
240292005479	metal binding site [ion binding]; metal-binding site
240292005480	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292005481	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292005482	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240292005483	Predicted integral membrane protein [Function unknown]; Region: COG5542
240292005484	Predicted integral membrane protein [Function unknown]; Region: COG5542
240292005485	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
240292005486	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
240292005487	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
240292005488	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
240292005489	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
240292005490	MoaE interaction surface [polypeptide binding]; other site
240292005491	MoeB interaction surface [polypeptide binding]; other site
240292005492	thiocarboxylated glycine; other site
240292005493	pheophorbide a oxygenase; Region: PLN02518
240292005494	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
240292005495	iron-sulfur cluster [ion binding]; other site
240292005496	[2Fe-2S] cluster binding site [ion binding]; other site
240292005497	Pheophorbide a oxygenase; Region: PaO; pfam08417
240292005498	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292005499	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
240292005500	HSP70 interaction site [polypeptide binding]; other site
240292005501	Clp protease; Region: CLP_protease; pfam00574
240292005502	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
240292005503	oligomer interface [polypeptide binding]; other site
240292005504	active site residues [active]
240292005505	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
240292005506	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
240292005507	oligomer interface [polypeptide binding]; other site
240292005508	active site residues [active]
240292005509	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
240292005510	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
240292005511	metal ion-dependent adhesion site (MIDAS); other site
240292005512	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
240292005513	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
240292005514	metal ion-dependent adhesion site (MIDAS); other site
240292005515	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
240292005516	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292005517	putative metal binding site [ion binding]; other site
240292005518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
240292005519	GrpE; Region: GrpE; pfam01025
240292005520	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
240292005521	dimer interface [polypeptide binding]; other site
240292005522	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
240292005523	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
240292005524	Outer membrane lipoprotein; Region: YfiO; pfam13525
240292005525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005526	binding surface
240292005527	TPR motif; other site
240292005528	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240292005529	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
240292005530	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
240292005531	nucleotide binding site [chemical binding]; other site
240292005532	putative NEF/HSP70 interaction site [polypeptide binding]; other site
240292005533	SBD interface [polypeptide binding]; other site
240292005534	Predicted membrane protein [Function unknown]; Region: COG4270
240292005535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4446
240292005536	RDD family; Region: RDD; pfam06271
240292005537	ribosomal protein L33; Region: rpl33; CHL00104
240292005538	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
240292005539	Exoribonuclease R [Transcription]; Region: VacB; COG0557
240292005540	RNB domain; Region: RNB; pfam00773
240292005541	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292005542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292005543	ATP binding site [chemical binding]; other site
240292005544	putative Mg++ binding site [ion binding]; other site
240292005545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292005546	nucleotide binding region [chemical binding]; other site
240292005547	ATP-binding site [chemical binding]; other site
240292005548	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292005549	Transposase IS200 like; Region: Y1_Tnp; pfam01797
240292005550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292005551	ATP-binding site [chemical binding]; other site
240292005552	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
240292005553	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292005554	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292005555	Integrase core domain; Region: rve; pfam00665
240292005556	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292005557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292005558	AAA domain; Region: AAA_22; pfam13401
240292005559	Walker A motif; other site
240292005560	ATP binding site [chemical binding]; other site
240292005561	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
240292005562	PLD-like domain; Region: PLDc_2; pfam13091
240292005563	putative active site [active]
240292005564	catalytic site [active]
240292005565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
240292005566	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292005567	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292005568	structural tetrad; other site
240292005569	AAA domain; Region: AAA_22; pfam13401
240292005570	Homeodomain-like domain; Region: HTH_23; pfam13384
240292005571	Winged helix-turn helix; Region: HTH_29; pfam13551
240292005572	Integrase core domain; Region: rve; pfam00665
240292005573	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292005574	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240292005575	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292005576	putative active site [active]
240292005577	heme pocket [chemical binding]; other site
240292005578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292005579	dimer interface [polypeptide binding]; other site
240292005580	phosphorylation site [posttranslational modification]
240292005581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292005582	ATP binding site [chemical binding]; other site
240292005583	Mg2+ binding site [ion binding]; other site
240292005584	G-X-G motif; other site
240292005585	Response regulator receiver domain; Region: Response_reg; pfam00072
240292005586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292005587	active site
240292005588	phosphorylation site [posttranslational modification]
240292005589	intermolecular recognition site; other site
240292005590	dimerization interface [polypeptide binding]; other site
240292005591	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
240292005592	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
240292005593	active site
240292005594	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
240292005595	dimer interface [polypeptide binding]; other site
240292005596	[2Fe-2S] cluster binding site [ion binding]; other site
240292005597	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240292005598	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240292005599	dimer interface [polypeptide binding]; other site
240292005600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292005601	catalytic residue [active]
240292005602	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292005603	Dynamin family; Region: Dynamin_N; pfam00350
240292005604	G1 box; other site
240292005605	GTP/Mg2+ binding site [chemical binding]; other site
240292005606	G2 box; other site
240292005607	Switch I region; other site
240292005608	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
240292005609	G3 box; other site
240292005610	Switch II region; other site
240292005611	GTP/Mg2+ binding site [chemical binding]; other site
240292005612	G4 box; other site
240292005613	G5 box; other site
240292005614	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
240292005615	Dynamin family; Region: Dynamin_N; pfam00350
240292005616	G1 box; other site
240292005617	GTP/Mg2+ binding site [chemical binding]; other site
240292005618	G2 box; other site
240292005619	Switch I region; other site
240292005620	G3 box; other site
240292005621	Switch II region; other site
240292005622	G4 box; other site
240292005623	G5 box; other site
240292005624	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292005625	HSP70 interaction site [polypeptide binding]; other site
240292005626	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
240292005627	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
240292005628	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
240292005629	metal ion-dependent adhesion site (MIDAS); other site
240292005630	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
240292005631	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
240292005632	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
240292005633	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292005634	putative active site [active]
240292005635	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240292005636	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
240292005637	dimer interface [polypeptide binding]; other site
240292005638	decamer (pentamer of dimers) interface [polypeptide binding]; other site
240292005639	catalytic triad [active]
240292005640	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
240292005641	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292005642	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240292005643	metal ion-dependent adhesion site (MIDAS); other site
240292005644	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
240292005645	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292005646	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292005647	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292005648	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
240292005649	putative ADP-binding pocket [chemical binding]; other site
240292005650	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292005651	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292005652	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292005653	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
240292005654	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292005655	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
240292005656	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292005657	active site
240292005658	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
240292005659	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
240292005660	FAD binding domain; Region: FAD_binding_4; pfam01565
240292005661	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292005662	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292005663	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
240292005664	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292005665	Predicted membrane protein [Function unknown]; Region: COG3431
240292005666	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292005667	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292005668	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292005669	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
240292005670	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
240292005671	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292005672	catalytic residue [active]
240292005673	Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693
240292005674	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
240292005675	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
240292005676	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
240292005677	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
240292005678	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292005679	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
240292005680	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
240292005681	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292005682	active site
240292005683	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292005684	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
240292005685	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240292005686	O-Antigen ligase; Region: Wzy_C; pfam04932
240292005687	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292005688	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
240292005689	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
240292005690	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292005691	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292005692	active site
240292005693	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292005694	Chain length determinant protein; Region: Wzz; pfam02706
240292005695	WAHD domain of WASH complex; Region: WASH_WAHD; pfam11945
240292005696	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
240292005697	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240292005698	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292005699	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
240292005700	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292005701	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292005702	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
240292005703	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292005704	Double zinc ribbon; Region: DZR; pfam12773
240292005705	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
240292005706	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
240292005707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
240292005708	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
240292005709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
240292005710	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
240292005711	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
240292005712	AmpG-like permease; Region: 2A0125; TIGR00901
240292005713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292005714	Coenzyme A binding pocket [chemical binding]; other site
240292005715	HEAT repeats; Region: HEAT_2; pfam13646
240292005716	HEAT repeats; Region: HEAT_2; pfam13646
240292005717	HEAT repeats; Region: HEAT_2; pfam13646
240292005718	Cupin domain; Region: Cupin_2; cl17218
240292005719	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
240292005720	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
240292005721	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240292005722	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
240292005723	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
240292005724	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292005725	Fasciclin domain; Region: Fasciclin; pfam02469
240292005726	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
240292005727	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292005728	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292005729	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292005730	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292005731	DNA binding residues [nucleotide binding]
240292005732	light-harvesting-like protein 3; Provisional; Region: PLN00014
240292005733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292005734	AAA domain; Region: AAA_21; pfam13304
240292005735	Walker A/P-loop; other site
240292005736	ATP binding site [chemical binding]; other site
240292005737	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
240292005738	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292005739	active site
240292005740	catalytic tetrad [active]
240292005741	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292005742	Bifunctional nuclease; Region: DNase-RNase; pfam02577
240292005743	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
240292005744	Lumazine binding domain; Region: Lum_binding; pfam00677
240292005745	Lumazine binding domain; Region: Lum_binding; pfam00677
240292005746	Ustilago B locus mating-type protein; Region: Ustilago_mating; pfam05722
240292005747	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292005748	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292005749	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
240292005750	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
240292005751	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
240292005752	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
240292005753	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
240292005754	Sodium Bile acid symporter family; Region: SBF; cl17470
240292005755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
240292005756	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
240292005757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292005758	S-adenosylmethionine binding site [chemical binding]; other site
240292005759	Response regulator receiver domain; Region: Response_reg; pfam00072
240292005760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292005761	active site
240292005762	phosphorylation site [posttranslational modification]
240292005763	intermolecular recognition site; other site
240292005764	dimerization interface [polypeptide binding]; other site
240292005765	GAF domain; Region: GAF; pfam01590
240292005766	GAF domain; Region: GAF_2; pfam13185
240292005767	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
240292005768	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
240292005769	Family description; Region: UvrD_C_2; pfam13538
240292005770	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
240292005771	Trehalase; Region: Trehalase; cl17346
240292005772	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
240292005773	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
240292005774	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
240292005775	active site
240292005776	catalytic site [active]
240292005777	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
240292005778	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
240292005779	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
240292005780	catalytic site [active]
240292005781	active site
240292005782	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
240292005783	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
240292005784	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
240292005785	active site
240292005786	catalytic site [active]
240292005787	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
240292005788	starch-binding site 2 [chemical binding]; other site
240292005789	starch-binding site 1 [chemical binding]; other site
240292005790	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
240292005791	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
240292005792	active site
240292005793	substrate binding site [chemical binding]; other site
240292005794	FMN binding site [chemical binding]; other site
240292005795	putative catalytic residues [active]
240292005796	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292005797	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292005798	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292005799	DevC protein; Region: devC; TIGR01185
240292005800	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292005801	FtsX-like permease family; Region: FtsX; pfam02687
240292005802	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292005803	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292005804	Walker A/P-loop; other site
240292005805	ATP binding site [chemical binding]; other site
240292005806	Q-loop/lid; other site
240292005807	ABC transporter signature motif; other site
240292005808	Walker B; other site
240292005809	D-loop; other site
240292005810	H-loop/switch region; other site
240292005811	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292005812	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292005813	ligand binding site [chemical binding]; other site
240292005814	flexible hinge region; other site
240292005815	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
240292005816	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
240292005817	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
240292005818	hinge; other site
240292005819	active site
240292005820	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
240292005821	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
240292005822	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240292005823	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292005824	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
240292005825	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
240292005826	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292005827	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292005828	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292005829	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292005830	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292005831	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292005832	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292005833	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292005834	putative active site [active]
240292005835	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292005836	putative active site [active]
240292005837	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292005838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005839	binding surface
240292005840	TPR motif; other site
240292005841	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292005842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292005843	binding surface
240292005844	TPR motif; other site
240292005845	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292005846	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
240292005847	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
240292005848	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
240292005849	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292005850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292005851	active site
240292005852	phosphorylation site [posttranslational modification]
240292005853	intermolecular recognition site; other site
240292005854	dimerization interface [polypeptide binding]; other site
240292005855	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292005856	DNA binding site [nucleotide binding]
240292005857	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292005858	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
240292005859	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292005860	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292005861	active site
240292005862	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292005863	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240292005864	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292005865	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240292005866	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
240292005867	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292005868	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
240292005869	Walker A/P-loop; other site
240292005870	ATP binding site [chemical binding]; other site
240292005871	Q-loop/lid; other site
240292005872	ABC transporter signature motif; other site
240292005873	Walker B; other site
240292005874	D-loop; other site
240292005875	H-loop/switch region; other site
240292005876	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240292005877	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292005878	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
240292005879	active site
240292005880	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
240292005881	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
240292005882	catalytic motif [active]
240292005883	Zn binding site [ion binding]; other site
240292005884	RibD C-terminal domain; Region: RibD_C; cl17279
240292005885	XisI protein; Region: XisI; pfam08869
240292005886	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
240292005887	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
240292005888	rod shape-determining protein MreC; Region: MreC; pfam04085
240292005889	rod shape-determining protein MreB; Provisional; Region: PRK13927
240292005890	MreB and similar proteins; Region: MreB_like; cd10225
240292005891	nucleotide binding site [chemical binding]; other site
240292005892	Mg binding site [ion binding]; other site
240292005893	putative protofilament interaction site [polypeptide binding]; other site
240292005894	RodZ interaction site [polypeptide binding]; other site
240292005895	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240292005896	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240292005897	dimer interface [polypeptide binding]; other site
240292005898	ssDNA binding site [nucleotide binding]; other site
240292005899	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240292005900	Uncharacterized conserved protein [Function unknown]; Region: COG2968
240292005901	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
240292005902	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292005903	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240292005904	AMIN domain; Region: AMIN; pfam11741
240292005905	AMIN domain; Region: AMIN; pfam11741
240292005906	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292005907	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240292005908	active site
240292005909	metal binding site [ion binding]; metal-binding site
240292005910	AMIN domain; Region: AMIN; pfam11741
240292005911	AMIN domain; Region: AMIN; pfam11741
240292005912	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292005913	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240292005914	active site
240292005915	metal binding site [ion binding]; metal-binding site
240292005916	glutamate racemase; Provisional; Region: PRK00865
240292005917	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
240292005918	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
240292005919	substrate binding pocket [chemical binding]; other site
240292005920	chain length determination region; other site
240292005921	substrate-Mg2+ binding site; other site
240292005922	catalytic residues [active]
240292005923	aspartate-rich region 1; other site
240292005924	active site lid residues [active]
240292005925	aspartate-rich region 2; other site
240292005926	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
240292005927	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
240292005928	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
240292005929	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
240292005930	hypothetical protein; Provisional; Region: PRK04323
240292005931	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
240292005932	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
240292005933	catalytic site [active]
240292005934	G-X2-G-X-G-K; other site
240292005935	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
240292005936	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
240292005937	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
240292005938	UGMP family protein; Validated; Region: PRK09604
240292005939	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
240292005940	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292005941	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
240292005942	catalytic site [active]
240292005943	Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479
240292005944	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292005945	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292005946	Coenzyme A binding pocket [chemical binding]; other site
240292005947	Tic22-like family; Region: Tic22; cl04468
240292005948	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
240292005949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292005950	S-adenosylmethionine binding site [chemical binding]; other site
240292005951	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
240292005952	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292005953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292005954	dimer interface [polypeptide binding]; other site
240292005955	phosphorylation site [posttranslational modification]
240292005956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292005957	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292005958	Coenzyme A binding pocket [chemical binding]; other site
240292005959	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
240292005960	Protein export membrane protein; Region: SecD_SecF; pfam02355
240292005961	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
240292005962	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
240292005963	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
240292005964	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
240292005965	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
240292005966	alpha subunit interface [polypeptide binding]; other site
240292005967	TPP binding site [chemical binding]; other site
240292005968	heterodimer interface [polypeptide binding]; other site
240292005969	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240292005970	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292005971	putative active site [active]
240292005972	Leucine rich repeat; Region: LRR_8; pfam13855
240292005973	Leucine rich repeat; Region: LRR_8; pfam13855
240292005974	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
240292005975	Leucine-rich repeats; other site
240292005976	Substrate binding site [chemical binding]; other site
240292005977	Leucine rich repeat; Region: LRR_8; pfam13855
240292005978	Leucine rich repeat; Region: LRR_8; pfam13855
240292005979	Leucine rich repeat; Region: LRR_8; pfam13855
240292005980	Leucine rich repeat; Region: LRR_8; pfam13855
240292005981	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
240292005982	Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914
240292005983	G1 box; other site
240292005984	GTP/Mg2+ binding site [chemical binding]; other site
240292005985	G2 box; other site
240292005986	Switch I region; other site
240292005987	G3 box; other site
240292005988	Switch II region; other site
240292005989	G4 box; other site
240292005990	G5 box; other site
240292005991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292005992	salt bridge; other site
240292005993	non-specific DNA binding site [nucleotide binding]; other site
240292005994	sequence-specific DNA binding site [nucleotide binding]; other site
240292005995	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
240292005996	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
240292005997	Walker A/P-loop; other site
240292005998	ATP binding site [chemical binding]; other site
240292005999	Q-loop/lid; other site
240292006000	ABC transporter signature motif; other site
240292006001	Walker B; other site
240292006002	D-loop; other site
240292006003	H-loop/switch region; other site
240292006004	TOBE-like domain; Region: TOBE_3; pfam12857
240292006005	Haemolytic domain; Region: Haemolytic; cl00506
240292006006	geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093
240292006007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292006008	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292006009	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292006010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006011	active site
240292006012	phosphorylation site [posttranslational modification]
240292006013	intermolecular recognition site; other site
240292006014	dimerization interface [polypeptide binding]; other site
240292006015	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292006016	DNA binding site [nucleotide binding]
240292006017	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
240292006018	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292006019	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
240292006020	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006021	putative active site [active]
240292006022	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006023	putative active site [active]
240292006024	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292006025	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292006026	motif II; other site
240292006027	30S ribosomal protein S1; Reviewed; Region: PRK07400
240292006028	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
240292006029	RNA binding site [nucleotide binding]; other site
240292006030	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
240292006031	RNA binding site [nucleotide binding]; other site
240292006032	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
240292006033	RNA binding site [nucleotide binding]; other site
240292006034	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
240292006035	photosystem II 47 kDa protein; Region: psbB; CHL00062
240292006036	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
240292006037	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
240292006038	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
240292006039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292006040	dimer interface [polypeptide binding]; other site
240292006041	conserved gate region; other site
240292006042	putative PBP binding loops; other site
240292006043	ABC-ATPase subunit interface; other site
240292006044	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
240292006045	RNA/DNA hybrid binding site [nucleotide binding]; other site
240292006046	active site
240292006047	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
240292006048	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
240292006049	active site
240292006050	Predicted membrane protein [Function unknown]; Region: COG2324
240292006051	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
240292006052	ribosomal protein L21; Region: rpl21; CHL00075
240292006053	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
240292006054	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
240292006055	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
240292006056	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
240292006057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240292006058	Walker A motif; other site
240292006059	ATP binding site [chemical binding]; other site
240292006060	Beta-lactamase; Region: Beta-lactamase; pfam00144
240292006061	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
240292006062	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
240292006063	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
240292006064	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292006065	phosphopeptide binding site; other site
240292006066	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292006067	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292006068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292006069	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
240292006070	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292006071	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292006072	active site
240292006073	catalytic tetrad [active]
240292006074	cytochrome c6; Provisional; Region: PRK13697
240292006075	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240292006076	Mnd1 family; Region: Mnd1; pfam03962
240292006077	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
240292006078	Predicted membrane protein [Function unknown]; Region: COG1950
240292006079	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292006080	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292006081	catalytic loop [active]
240292006082	iron binding site [ion binding]; other site
240292006083	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
240292006084	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
240292006085	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
240292006086	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
240292006087	RNA binding site [nucleotide binding]; other site
240292006088	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292006089	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292006090	P-loop; other site
240292006091	Magnesium ion binding site [ion binding]; other site
240292006092	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
240292006093	active site
240292006094	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292006095	G2 box; other site
240292006096	Switch I region; other site
240292006097	G3 box; other site
240292006098	Switch II region; other site
240292006099	G4 box; other site
240292006100	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292006101	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006102	structural tetrad; other site
240292006103	EamA-like transporter family; Region: EamA; pfam00892
240292006104	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
240292006105	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
240292006106	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
240292006107	G1 box; other site
240292006108	GTP/Mg2+ binding site [chemical binding]; other site
240292006109	Switch I region; other site
240292006110	G2 box; other site
240292006111	Switch II region; other site
240292006112	G3 box; other site
240292006113	G4 box; other site
240292006114	G5 box; other site
240292006115	Domain of unknown function (DUF697); Region: DUF697; pfam05128
240292006116	CAAX protease self-immunity; Region: Abi; pfam02517
240292006117	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
240292006118	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
240292006119	metal-binding site [ion binding]
240292006120	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292006121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292006122	motif II; other site
240292006123	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292006124	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292006125	phosphopeptide binding site; other site
240292006126	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
240292006127	Protein kinase domain; Region: Pkinase; pfam00069
240292006128	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292006129	active site
240292006130	ATP binding site [chemical binding]; other site
240292006131	substrate binding site [chemical binding]; other site
240292006132	activation loop (A-loop); other site
240292006133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006134	binding surface
240292006135	TPR motif; other site
240292006136	TPR repeat; Region: TPR_11; pfam13414
240292006137	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240292006138	Tetratricopeptide repeat; Region: TPR_1; pfam00515
240292006139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006140	binding surface
240292006141	TPR motif; other site
240292006142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006143	binding surface
240292006144	TPR motif; other site
240292006145	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
240292006146	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
240292006147	NAD binding site [chemical binding]; other site
240292006148	catalytic residues [active]
240292006149	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
240292006150	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006151	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006152	Protein of unknown function, DUF258; Region: DUF258; pfam03193
240292006153	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006154	structural tetrad; other site
240292006155	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292006156	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006157	structural tetrad; other site
240292006158	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006159	structural tetrad; other site
240292006160	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
240292006161	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292006162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006163	active site
240292006164	phosphorylation site [posttranslational modification]
240292006165	intermolecular recognition site; other site
240292006166	dimerization interface [polypeptide binding]; other site
240292006167	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292006168	DNA binding residues [nucleotide binding]
240292006169	dimerization interface [polypeptide binding]; other site
240292006170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006171	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292006172	putative active site [active]
240292006173	heme pocket [chemical binding]; other site
240292006174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006175	putative active site [active]
240292006176	heme pocket [chemical binding]; other site
240292006177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006178	dimer interface [polypeptide binding]; other site
240292006179	phosphorylation site [posttranslational modification]
240292006180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006181	ATP binding site [chemical binding]; other site
240292006182	Mg2+ binding site [ion binding]; other site
240292006183	G-X-G motif; other site
240292006184	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006186	active site
240292006187	phosphorylation site [posttranslational modification]
240292006188	intermolecular recognition site; other site
240292006189	dimerization interface [polypeptide binding]; other site
240292006190	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292006191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006192	active site
240292006193	phosphorylation site [posttranslational modification]
240292006194	intermolecular recognition site; other site
240292006195	dimerization interface [polypeptide binding]; other site
240292006196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006197	dimer interface [polypeptide binding]; other site
240292006198	phosphorylation site [posttranslational modification]
240292006199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006200	ATP binding site [chemical binding]; other site
240292006201	Mg2+ binding site [ion binding]; other site
240292006202	G-X-G motif; other site
240292006203	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006205	active site
240292006206	phosphorylation site [posttranslational modification]
240292006207	intermolecular recognition site; other site
240292006208	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292006209	dimerization interface [polypeptide binding]; other site
240292006210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006211	dimer interface [polypeptide binding]; other site
240292006212	phosphorylation site [posttranslational modification]
240292006213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006214	ATP binding site [chemical binding]; other site
240292006215	Mg2+ binding site [ion binding]; other site
240292006216	G-X-G motif; other site
240292006217	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
240292006218	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
240292006219	peptide binding site [polypeptide binding]; other site
240292006220	dimer interface [polypeptide binding]; other site
240292006221	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292006222	GAF domain; Region: GAF; pfam01590
240292006223	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
240292006224	PAS domain; Region: PAS_9; pfam13426
240292006225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006226	putative active site [active]
240292006227	heme pocket [chemical binding]; other site
240292006228	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292006229	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292006230	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292006231	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292006232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292006233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006234	dimer interface [polypeptide binding]; other site
240292006235	phosphorylation site [posttranslational modification]
240292006236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006237	ATP binding site [chemical binding]; other site
240292006238	Mg2+ binding site [ion binding]; other site
240292006239	G-X-G motif; other site
240292006240	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006242	active site
240292006243	phosphorylation site [posttranslational modification]
240292006244	intermolecular recognition site; other site
240292006245	dimerization interface [polypeptide binding]; other site
240292006246	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006248	active site
240292006249	phosphorylation site [posttranslational modification]
240292006250	intermolecular recognition site; other site
240292006251	dimerization interface [polypeptide binding]; other site
240292006252	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292006253	putative binding surface; other site
240292006254	active site
240292006255	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
240292006256	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
240292006257	Mg2+ binding site [ion binding]; other site
240292006258	G-X-G motif; other site
240292006259	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006261	active site
240292006262	phosphorylation site [posttranslational modification]
240292006263	intermolecular recognition site; other site
240292006264	dimerization interface [polypeptide binding]; other site
240292006265	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240292006266	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240292006267	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292006268	anti sigma factor interaction site; other site
240292006269	regulatory phosphorylation site [posttranslational modification]; other site
240292006270	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292006271	active site
240292006272	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292006273	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292006274	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
240292006275	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
240292006276	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
240292006277	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
240292006278	classical (c) SDRs; Region: SDR_c; cd05233
240292006279	NAD(P) binding site [chemical binding]; other site
240292006280	active site
240292006281	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
240292006282	ferrochelatase; Reviewed; Region: hemH; PRK00035
240292006283	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
240292006284	active site
240292006285	C-terminal domain interface [polypeptide binding]; other site
240292006286	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
240292006287	active site
240292006288	N-terminal domain interface [polypeptide binding]; other site
240292006289	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292006290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292006291	S-adenosylmethionine binding site [chemical binding]; other site
240292006292	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292006293	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292006294	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
240292006295	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
240292006296	active site
240292006297	putative substrate binding pocket [chemical binding]; other site
240292006298	Isochorismatase family; Region: Isochorismatase; pfam00857
240292006299	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
240292006300	catalytic triad [active]
240292006301	conserved cis-peptide bond; other site
240292006302	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
240292006303	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
240292006304	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240292006305	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292006306	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292006307	dimerization interface [polypeptide binding]; other site
240292006308	putative DNA binding site [nucleotide binding]; other site
240292006309	putative Zn2+ binding site [ion binding]; other site
240292006310	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
240292006311	pheophytin binding site; other site
240292006312	chlorophyll binding site; other site
240292006313	quinone binding site; other site
240292006314	Fe binding site [ion binding]; other site
240292006315	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
240292006316	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
240292006317	FMN binding site [chemical binding]; other site
240292006318	substrate binding site [chemical binding]; other site
240292006319	putative catalytic residue [active]
240292006320	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292006321	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292006322	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292006323	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292006324	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292006325	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292006326	GTPase CgtA; Reviewed; Region: obgE; PRK12299
240292006327	GTP1/OBG; Region: GTP1_OBG; pfam01018
240292006328	Obg GTPase; Region: Obg; cd01898
240292006329	G1 box; other site
240292006330	GTP/Mg2+ binding site [chemical binding]; other site
240292006331	Switch I region; other site
240292006332	G2 box; other site
240292006333	G3 box; other site
240292006334	Switch II region; other site
240292006335	G4 box; other site
240292006336	G5 box; other site
240292006337	tellurium resistance terB-like protein; Region: terB_like; cd07177
240292006338	metal binding site [ion binding]; metal-binding site
240292006339	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292006340	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006341	putative active site [active]
240292006342	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
240292006343	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
240292006344	putative active site; other site
240292006345	catalytic residue [active]
240292006346	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006348	binding surface
240292006349	TPR motif; other site
240292006350	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006353	binding surface
240292006354	TPR motif; other site
240292006355	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006356	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006358	binding surface
240292006359	TPR motif; other site
240292006360	Protein kinase domain; Region: Pkinase; pfam00069
240292006361	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292006362	active site
240292006363	ATP binding site [chemical binding]; other site
240292006364	substrate binding site [chemical binding]; other site
240292006365	activation loop (A-loop); other site
240292006366	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
240292006367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292006368	Walker A/P-loop; other site
240292006369	ATP binding site [chemical binding]; other site
240292006370	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
240292006371	active site
240292006372	metal binding site [ion binding]; metal-binding site
240292006373	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
240292006374	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
240292006375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292006376	S-adenosylmethionine binding site [chemical binding]; other site
240292006377	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
240292006378	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292006379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292006380	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
240292006381	protein I interface; other site
240292006382	D2 interface; other site
240292006383	protein T interface; other site
240292006384	chlorophyll binding site; other site
240292006385	beta carotene binding site; other site
240292006386	pheophytin binding site; other site
240292006387	manganese-stabilizing polypeptide interface; other site
240292006388	CP43 interface; other site
240292006389	protein L interface; other site
240292006390	oxygen evolving complex binding site; other site
240292006391	bromide binding site; other site
240292006392	quinone binding site; other site
240292006393	Fe binding site [ion binding]; other site
240292006394	core light harvesting interface; other site
240292006395	cytochrome b559 alpha subunit interface; other site
240292006396	cytochrome c-550 interface; other site
240292006397	protein J interface; other site
240292006398	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
240292006399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292006400	FeS/SAM binding site; other site
240292006401	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
240292006402	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292006403	ABC-ATPase subunit  interface; other site
240292006404	dimer interface [polypeptide binding]; other site
240292006405	putative PBP binding regions; other site
240292006406	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
240292006407	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
240292006408	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
240292006409	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
240292006410	metal binding site [ion binding]; metal-binding site
240292006411	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
240292006412	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
240292006413	active site
240292006414	PHP Thumb interface [polypeptide binding]; other site
240292006415	metal binding site [ion binding]; metal-binding site
240292006416	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
240292006417	protein-splicing catalytic site; other site
240292006418	thioester formation/cholesterol transfer; other site
240292006419	Transposase domain (DUF772); Region: DUF772; pfam05598
240292006420	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292006421	Homeodomain-like domain; Region: HTH_23; pfam13384
240292006422	Winged helix-turn helix; Region: HTH_29; pfam13551
240292006423	Winged helix-turn helix; Region: HTH_33; pfam13592
240292006424	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292006425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
240292006426	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
240292006427	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
240292006428	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
240292006429	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
240292006430	acyl-activating enzyme (AAE) consensus motif; other site
240292006431	putative AMP binding site [chemical binding]; other site
240292006432	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
240292006433	putative NADP binding site [chemical binding]; other site
240292006434	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
240292006435	active site
240292006436	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006437	Condensation domain; Region: Condensation; pfam00668
240292006438	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006439	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006440	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
240292006441	acyl-activating enzyme (AAE) consensus motif; other site
240292006442	AMP binding site [chemical binding]; other site
240292006443	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006444	Condensation domain; Region: Condensation; pfam00668
240292006445	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006446	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006447	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292006448	acyl-activating enzyme (AAE) consensus motif; other site
240292006449	AMP binding site [chemical binding]; other site
240292006450	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006451	Condensation domain; Region: Condensation; pfam00668
240292006452	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006453	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006454	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292006455	acyl-activating enzyme (AAE) consensus motif; other site
240292006456	AMP binding site [chemical binding]; other site
240292006457	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006458	Condensation domain; Region: Condensation; pfam00668
240292006459	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006460	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006461	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292006462	acyl-activating enzyme (AAE) consensus motif; other site
240292006463	AMP binding site [chemical binding]; other site
240292006464	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006465	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292006466	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
240292006467	active site
240292006468	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292006469	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292006470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292006471	S-adenosylmethionine binding site [chemical binding]; other site
240292006472	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006473	Condensation domain; Region: Condensation; pfam00668
240292006474	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006475	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006476	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292006477	acyl-activating enzyme (AAE) consensus motif; other site
240292006478	AMP binding site [chemical binding]; other site
240292006479	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006480	Condensation domain; Region: Condensation; pfam00668
240292006481	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006482	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292006483	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292006484	acyl-activating enzyme (AAE) consensus motif; other site
240292006485	AMP binding site [chemical binding]; other site
240292006486	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006487	Condensation domain; Region: Condensation; pfam00668
240292006488	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292006489	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
240292006490	Condensation domain; Region: Condensation; pfam00668
240292006491	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292006492	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
240292006493	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
240292006494	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292006495	catalytic Zn binding site [ion binding]; other site
240292006496	structural Zn binding site [ion binding]; other site
240292006497	tetramer interface [polypeptide binding]; other site
240292006498	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
240292006499	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
240292006500	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
240292006501	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
240292006502	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
240292006503	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
240292006504	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292006505	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
240292006506	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292006507	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
240292006508	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
240292006509	active site
240292006510	nucleophile elbow; other site
240292006511	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
240292006512	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
240292006513	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
240292006514	GUN4-like; Region: GUN4; pfam05419
240292006515	WD domain, G-beta repeat; Region: WD40; pfam00400
240292006516	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292006517	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006518	structural tetrad; other site
240292006519	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292006520	structural tetrad; other site
240292006521	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292006522	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006524	active site
240292006525	phosphorylation site [posttranslational modification]
240292006526	intermolecular recognition site; other site
240292006527	dimerization interface [polypeptide binding]; other site
240292006528	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006530	active site
240292006531	phosphorylation site [posttranslational modification]
240292006532	intermolecular recognition site; other site
240292006533	dimerization interface [polypeptide binding]; other site
240292006534	Cache domain; Region: Cache_1; pfam02743
240292006535	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292006536	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006537	putative active site [active]
240292006538	heme pocket [chemical binding]; other site
240292006539	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292006540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006541	putative active site [active]
240292006542	heme pocket [chemical binding]; other site
240292006543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006544	dimer interface [polypeptide binding]; other site
240292006545	phosphorylation site [posttranslational modification]
240292006546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006547	ATP binding site [chemical binding]; other site
240292006548	Mg2+ binding site [ion binding]; other site
240292006549	G-X-G motif; other site
240292006550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292006551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006552	active site
240292006553	phosphorylation site [posttranslational modification]
240292006554	intermolecular recognition site; other site
240292006555	dimerization interface [polypeptide binding]; other site
240292006556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292006557	DNA binding site [nucleotide binding]
240292006558	Hpt domain; Region: Hpt; pfam01627
240292006559	putative binding surface; other site
240292006560	active site
240292006561	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006563	active site
240292006564	phosphorylation site [posttranslational modification]
240292006565	intermolecular recognition site; other site
240292006566	dimerization interface [polypeptide binding]; other site
240292006567	Phytochelatin synthase; Region: Phytochelatin; pfam05023
240292006568	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240292006569	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292006570	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292006571	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240292006572	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
240292006573	Ligand Binding Site [chemical binding]; other site
240292006574	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292006575	AMIN domain; Region: AMIN; pfam11741
240292006576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292006577	Probable transposase; Region: OrfB_IS605; pfam01385
240292006578	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292006579	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292006580	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292006581	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292006582	Predicted permeases [General function prediction only]; Region: COG0795
240292006583	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
240292006584	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
240292006585	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
240292006586	Walker A/P-loop; other site
240292006587	ATP binding site [chemical binding]; other site
240292006588	Q-loop/lid; other site
240292006589	ABC transporter signature motif; other site
240292006590	Walker B; other site
240292006591	D-loop; other site
240292006592	H-loop/switch region; other site
240292006593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
240292006594	OstA-like protein; Region: OstA; pfam03968
240292006595	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
240292006596	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
240292006597	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
240292006598	Protein of unknown function DUF58; Region: DUF58; pfam01882
240292006599	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
240292006600	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
240292006601	Protein of unknown function, DUF393; Region: DUF393; pfam04134
240292006602	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
240292006603	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292006604	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
240292006605	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
240292006606	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
240292006607	active site
240292006608	acyl-CoA synthetase; Validated; Region: PRK05850
240292006609	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
240292006610	acyl-activating enzyme (AAE) consensus motif; other site
240292006611	active site
240292006612	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
240292006613	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
240292006614	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
240292006615	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
240292006616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292006617	S-adenosylmethionine binding site [chemical binding]; other site
240292006618	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
240292006619	transketolase; Reviewed; Region: PRK05899
240292006620	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
240292006621	TPP-binding site [chemical binding]; other site
240292006622	dimer interface [polypeptide binding]; other site
240292006623	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
240292006624	PYR/PP interface [polypeptide binding]; other site
240292006625	dimer interface [polypeptide binding]; other site
240292006626	TPP binding site [chemical binding]; other site
240292006627	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240292006628	PRC-barrel domain; Region: PRC; pfam05239
240292006629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
240292006630	PRC-barrel domain; Region: PRC; pfam05239
240292006631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
240292006632	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
240292006633	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
240292006634	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
240292006635	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
240292006636	putative dimer interface [polypeptide binding]; other site
240292006637	N-terminal domain interface [polypeptide binding]; other site
240292006638	putative substrate binding pocket (H-site) [chemical binding]; other site
240292006639	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
240292006640	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
240292006641	active site residue [active]
240292006642	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
240292006643	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006644	putative active site [active]
240292006645	KWG Leptospira; Region: KWG; pfam07656
240292006646	KWG Leptospira; Region: KWG; pfam07656
240292006647	KWG Leptospira; Region: KWG; pfam07656
240292006648	KWG Leptospira; Region: KWG; pfam07656
240292006649	KWG Leptospira; Region: KWG; pfam07656
240292006650	KWG Leptospira; Region: KWG; pfam07656
240292006651	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
240292006652	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
240292006653	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
240292006654	trimer interface [polypeptide binding]; other site
240292006655	active site
240292006656	substrate binding site [chemical binding]; other site
240292006657	CoA binding site [chemical binding]; other site
240292006658	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
240292006659	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
240292006660	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
240292006661	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
240292006662	AMIN domain; Region: AMIN; pfam11741
240292006663	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292006664	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292006665	N-terminal plug; other site
240292006666	ligand-binding site [chemical binding]; other site
240292006667	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
240292006668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292006669	putative substrate translocation pore; other site
240292006670	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
240292006671	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
240292006672	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
240292006673	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
240292006674	TPR repeat; Region: TPR_11; pfam13414
240292006675	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006676	binding surface
240292006677	TPR motif; other site
240292006678	TPR repeat; Region: TPR_11; pfam13414
240292006679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292006680	binding surface
240292006681	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292006682	TPR motif; other site
240292006683	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292006684	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292006685	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
240292006686	AMP binding site [chemical binding]; other site
240292006687	metal binding site [ion binding]; metal-binding site
240292006688	active site
240292006689	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
240292006690	putative active site [active]
240292006691	transaldolase; Provisional; Region: PRK03903
240292006692	catalytic residue [active]
240292006693	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
240292006694	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
240292006695	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
240292006696	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
240292006697	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292006698	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
240292006699	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292006700	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
240292006701	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
240292006702	Permease; Region: Permease; cl00510
240292006703	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
240292006704	Colicin pore forming domain; Region: Colicin; pfam01024
240292006705	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
240292006706	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
240292006707	tandem repeat interface [polypeptide binding]; other site
240292006708	oligomer interface [polypeptide binding]; other site
240292006709	active site residues [active]
240292006710	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
240292006711	homotrimer interaction site [polypeptide binding]; other site
240292006712	active site
240292006713	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
240292006714	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
240292006715	putative NAD(P) binding site [chemical binding]; other site
240292006716	active site
240292006717	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292006718	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292006719	ligand binding site [chemical binding]; other site
240292006720	flexible hinge region; other site
240292006721	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
240292006722	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
240292006723	putative di-iron ligands [ion binding]; other site
240292006724	pyruvate kinase; Provisional; Region: PRK06354
240292006725	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
240292006726	domain interfaces; other site
240292006727	active site
240292006728	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
240292006729	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292006730	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292006731	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
240292006732	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292006733	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292006734	active site
240292006735	ATP binding site [chemical binding]; other site
240292006736	substrate binding site [chemical binding]; other site
240292006737	activation loop (A-loop); other site
240292006738	YARHG domain; Region: YARHG; pfam13308
240292006739	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
240292006740	GIY-YIG motif/motif A; other site
240292006741	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
240292006742	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
240292006743	putative catalytic cysteine [active]
240292006744	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
240292006745	homopentamer interface [polypeptide binding]; other site
240292006746	active site
240292006747	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
240292006748	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903
240292006749	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
240292006750	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
240292006751	DHH family; Region: DHH; pfam01368
240292006752	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292006753	FOG: CBS domain [General function prediction only]; Region: COG0517
240292006754	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
240292006755	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
240292006756	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
240292006757	active site
240292006758	NTP binding site [chemical binding]; other site
240292006759	metal binding triad [ion binding]; metal-binding site
240292006760	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
240292006761	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
240292006762	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
240292006763	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
240292006764	Walker A/P-loop; other site
240292006765	ATP binding site [chemical binding]; other site
240292006766	Q-loop/lid; other site
240292006767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292006768	ABC transporter signature motif; other site
240292006769	Walker B; other site
240292006770	D-loop; other site
240292006771	H-loop/switch region; other site
240292006772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292006773	AAA domain; Region: AAA_22; pfam13401
240292006774	Walker A motif; other site
240292006775	ATP binding site [chemical binding]; other site
240292006776	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292006777	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292006778	Integrase core domain; Region: rve; pfam00665
240292006779	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292006780	PAS fold; Region: PAS_4; pfam08448
240292006781	PAS fold; Region: PAS; pfam00989
240292006782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292006783	putative active site [active]
240292006784	heme pocket [chemical binding]; other site
240292006785	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006786	dimer interface [polypeptide binding]; other site
240292006787	phosphorylation site [posttranslational modification]
240292006788	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
240292006789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006790	ATP binding site [chemical binding]; other site
240292006791	Mg2+ binding site [ion binding]; other site
240292006792	G-X-G motif; other site
240292006793	Response regulator receiver domain; Region: Response_reg; pfam00072
240292006794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006795	active site
240292006796	phosphorylation site [posttranslational modification]
240292006797	intermolecular recognition site; other site
240292006798	dimerization interface [polypeptide binding]; other site
240292006799	S-layer homology domain; Region: SLH; pfam00395
240292006800	S-layer homology domain; Region: SLH; pfam00395
240292006801	S-layer homology domain; Region: SLH; pfam00395
240292006802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292006803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292006804	dimer interface [polypeptide binding]; other site
240292006805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292006806	ATP binding site [chemical binding]; other site
240292006807	Mg2+ binding site [ion binding]; other site
240292006808	G-X-G motif; other site
240292006809	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
240292006810	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
240292006811	Predicted transcriptional regulators [Transcription]; Region: COG1695
240292006812	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
240292006813	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
240292006814	seryl-tRNA synthetase; Provisional; Region: PRK05431
240292006815	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
240292006816	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
240292006817	dimer interface [polypeptide binding]; other site
240292006818	active site
240292006819	motif 1; other site
240292006820	motif 2; other site
240292006821	motif 3; other site
240292006822	Protein of unknown function (DUF433); Region: DUF433; pfam04255
240292006823	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
240292006824	putative active site [active]
240292006825	RIP metalloprotease RseP; Region: TIGR00054
240292006826	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
240292006827	active site
240292006828	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
240292006829	protein binding site [polypeptide binding]; other site
240292006830	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
240292006831	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
240292006832	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
240292006833	minor groove reading motif; other site
240292006834	helix-hairpin-helix signature motif; other site
240292006835	substrate binding pocket [chemical binding]; other site
240292006836	active site
240292006837	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
240292006838	ribosomal protein S14; Region: rps14; CHL00074
240292006839	Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360
240292006840	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
240292006841	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
240292006842	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
240292006843	active site
240292006844	substrate binding site [chemical binding]; other site
240292006845	metal binding site [ion binding]; metal-binding site
240292006846	Uncharacterized conserved protein [Function unknown]; Region: COG1479
240292006847	Protein of unknown function DUF262; Region: DUF262; pfam03235
240292006848	Protein of unknown function DUF262; Region: DUF262; pfam03235
240292006849	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
240292006850	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
240292006851	Protein of unknown function (DUF433); Region: DUF433; pfam04255
240292006852	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006853	putative active site [active]
240292006854	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
240292006855	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292006856	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
240292006857	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
240292006858	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292006859	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
240292006860	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292006861	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292006862	catalytic residues [active]
240292006863	Predicted membrane protein [Function unknown]; Region: COG4094
240292006864	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
240292006865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292006866	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
240292006867	putative dimerization interface [polypeptide binding]; other site
240292006868	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292006869	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292006870	putative switch regulator; other site
240292006871	non-specific DNA interactions [nucleotide binding]; other site
240292006872	DNA binding site [nucleotide binding]
240292006873	sequence specific DNA binding site [nucleotide binding]; other site
240292006874	putative cAMP binding site [chemical binding]; other site
240292006875	DALR anticodon binding domain; Region: DALR_1; smart00836
240292006876	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
240292006877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292006878	active site
240292006879	motif I; other site
240292006880	motif II; other site
240292006881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292006882	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292006883	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292006884	Walker A/P-loop; other site
240292006885	ATP binding site [chemical binding]; other site
240292006886	Q-loop/lid; other site
240292006887	ABC transporter signature motif; other site
240292006888	Walker B; other site
240292006889	D-loop; other site
240292006890	H-loop/switch region; other site
240292006891	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
240292006892	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
240292006893	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
240292006894	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292006895	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292006896	Walker A/P-loop; other site
240292006897	ATP binding site [chemical binding]; other site
240292006898	Q-loop/lid; other site
240292006899	ABC transporter signature motif; other site
240292006900	Walker B; other site
240292006901	D-loop; other site
240292006902	H-loop/switch region; other site
240292006903	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
240292006904	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
240292006905	cobalt transport protein CbiM; Validated; Region: PRK08319
240292006906	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
240292006907	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
240292006908	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
240292006909	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
240292006910	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
240292006911	Ferritin-like domain; Region: Ferritin; pfam00210
240292006912	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
240292006913	dinuclear metal binding motif [ion binding]; other site
240292006914	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
240292006915	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
240292006916	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
240292006917	putative ligand binding site [chemical binding]; other site
240292006918	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
240292006919	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292006920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292006921	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240292006922	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
240292006923	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292006924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292006925	homodimer interface [polypeptide binding]; other site
240292006926	catalytic residue [active]
240292006927	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240292006928	IHF dimer interface [polypeptide binding]; other site
240292006929	IHF - DNA interface [nucleotide binding]; other site
240292006930	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
240292006931	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292006932	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
240292006933	catalytic triad [active]
240292006934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292006935	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292006936	Short C-terminal domain; Region: SHOCT; pfam09851
240292006937	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
240292006938	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
240292006939	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
240292006940	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
240292006941	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
240292006942	active site
240292006943	dimer interface [polypeptide binding]; other site
240292006944	catalytic nucleophile [active]
240292006945	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
240292006946	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
240292006947	Substrate binding site; other site
240292006948	Mg++ binding site; other site
240292006949	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
240292006950	active site
240292006951	substrate binding site [chemical binding]; other site
240292006952	CoA binding site [chemical binding]; other site
240292006953	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
240292006954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292006955	active site
240292006956	phosphorylation site [posttranslational modification]
240292006957	intermolecular recognition site; other site
240292006958	dimerization interface [polypeptide binding]; other site
240292006959	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240292006960	Zn2+ binding site [ion binding]; other site
240292006961	Mg2+ binding site [ion binding]; other site
240292006962	Uncharacterized conserved protein [Function unknown]; Region: COG4121
240292006963	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
240292006964	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
240292006965	active site residue [active]
240292006966	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
240292006967	active site residue [active]
240292006968	Protein of unknown function (DUF560); Region: DUF560; pfam04575
240292006969	FecR protein; Region: FecR; pfam04773
240292006970	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
240292006971	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
240292006972	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
240292006973	CoA binding domain; Region: CoA_binding; smart00881
240292006974	CoA-ligase; Region: Ligase_CoA; pfam00549
240292006975	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
240292006976	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
240292006977	active site
240292006978	Zn binding site [ion binding]; other site
240292006979	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
240292006980	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292006981	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
240292006982	substrate binding site [chemical binding]; other site
240292006983	active site
240292006984	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292006985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292006986	NAD(P) binding site [chemical binding]; other site
240292006987	active site
240292006988	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292006989	putative active site [active]
240292006990	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240292006991	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240292006992	active site residue [active]
240292006993	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
240292006994	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292006995	dimerization interface [polypeptide binding]; other site
240292006996	putative DNA binding site [nucleotide binding]; other site
240292006997	putative Zn2+ binding site [ion binding]; other site
240292006998	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
240292006999	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
240292007000	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
240292007001	methionine sulfoxide reductase B; Provisional; Region: PRK00222
240292007002	SelR domain; Region: SelR; pfam01641
240292007003	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
240292007004	Peptidase family M50; Region: Peptidase_M50; pfam02163
240292007005	active site
240292007006	putative substrate binding region [chemical binding]; other site
240292007007	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
240292007008	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
240292007009	nudix motif; other site
240292007010	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292007011	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292007012	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
240292007013	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
240292007014	putative NAD(P) binding site [chemical binding]; other site
240292007015	active site
240292007016	pantothenate kinase; Reviewed; Region: PRK13331
240292007017	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292007018	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292007019	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292007020	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
240292007021	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292007022	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
240292007023	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240292007024	argininosuccinate lyase; Provisional; Region: PRK00855
240292007025	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
240292007026	active sites [active]
240292007027	tetramer interface [polypeptide binding]; other site
240292007028	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
240292007029	AIR carboxylase; Region: AIRC; smart01001
240292007030	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
240292007031	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
240292007032	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
240292007033	homotrimer interaction site [polypeptide binding]; other site
240292007034	zinc binding site [ion binding]; other site
240292007035	CDP-binding sites; other site
240292007036	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
240292007037	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
240292007038	proposed catalytic triad [active]
240292007039	active site nucleophile [active]
240292007040	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
240292007041	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292007042	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292007043	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292007044	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
240292007045	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292007046	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292007047	active site
240292007048	ATP binding site [chemical binding]; other site
240292007049	substrate binding site [chemical binding]; other site
240292007050	activation loop (A-loop); other site
240292007051	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
240292007052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292007053	S-adenosylmethionine binding site [chemical binding]; other site
240292007054	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
240292007055	phosphatidate cytidylyltransferase; Region: PLN02953
240292007056	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
240292007057	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
240292007058	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292007059	RNA binding surface [nucleotide binding]; other site
240292007060	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
240292007061	active site
240292007062	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
240292007063	Helix-turn-helix domain; Region: HTH_25; pfam13413
240292007064	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
240292007065	4-alpha-glucanotransferase; Provisional; Region: PRK14508
240292007066	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
240292007067	nudix motif; other site
240292007068	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
240292007069	homotrimer interaction site [polypeptide binding]; other site
240292007070	putative active site [active]
240292007071	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
240292007072	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292007073	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
240292007074	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
240292007075	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292007076	catalytic residue [active]
240292007077	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
240292007078	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
240292007079	iron-sulfur cluster [ion binding]; other site
240292007080	[2Fe-2S] cluster binding site [ion binding]; other site
240292007081	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292007082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292007083	Probable transposase; Region: OrfB_IS605; pfam01385
240292007084	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292007085	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
240292007086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292007087	FeS/SAM binding site; other site
240292007088	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
240292007089	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007090	putative active site [active]
240292007091	NurA nuclease; Region: NurA; smart00933
240292007092	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292007093	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
240292007094	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
240292007095	HflX GTPase family; Region: HflX; cd01878
240292007096	G1 box; other site
240292007097	GTP/Mg2+ binding site [chemical binding]; other site
240292007098	Switch I region; other site
240292007099	G2 box; other site
240292007100	G3 box; other site
240292007101	Switch II region; other site
240292007102	G4 box; other site
240292007103	G5 box; other site
240292007104	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
240292007105	GSH binding site [chemical binding]; other site
240292007106	catalytic residues [active]
240292007107	glutathione synthetase; Provisional; Region: PRK05246
240292007108	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
240292007109	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
240292007110	cell division protein FtsZ; Validated; Region: PRK09330
240292007111	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
240292007112	nucleotide binding site [chemical binding]; other site
240292007113	SulA interaction site; other site
240292007114	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
240292007115	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
240292007116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240292007117	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292007118	Protein of unknown function, DUF258; Region: DUF258; pfam03193
240292007119	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292007120	structural tetrad; other site
240292007121	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292007122	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292007123	structural tetrad; other site
240292007124	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
240292007125	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
240292007126	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292007127	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292007128	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292007129	DNA binding residues [nucleotide binding]
240292007130	von Willebrand factor type A domain; Region: VWA_2; pfam13519
240292007131	metal ion-dependent adhesion site (MIDAS); other site
240292007132	Tubulin like; Region: Tubulin_2; pfam13809
240292007133	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
240292007134	ligand binding site [chemical binding]; other site
240292007135	Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205
240292007136	PsbJ; Region: PsbJ; pfam01788
240292007137	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
240292007138	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
240292007139	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
240292007140	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
240292007141	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
240292007142	Ycf48-like protein; Provisional; Region: PRK13684
240292007143	Rubredoxin [Energy production and conversion]; Region: COG1773
240292007144	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
240292007145	iron binding site [ion binding]; other site
240292007146	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
240292007147	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
240292007148	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
240292007149	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
240292007150	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292007151	Tetratricopeptide repeat; Region: TPR_10; pfam13374
240292007152	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292007153	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292007154	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
240292007155	glucose-1-dehydrogenase; Provisional; Region: PRK08936
240292007156	NAD binding site [chemical binding]; other site
240292007157	homodimer interface [polypeptide binding]; other site
240292007158	active site
240292007159	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
240292007160	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
240292007161	translation initiation factor IF-2; Region: IF-2; TIGR00487
240292007162	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
240292007163	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
240292007164	G1 box; other site
240292007165	putative GEF interaction site [polypeptide binding]; other site
240292007166	GTP/Mg2+ binding site [chemical binding]; other site
240292007167	Switch I region; other site
240292007168	G2 box; other site
240292007169	G3 box; other site
240292007170	Switch II region; other site
240292007171	G4 box; other site
240292007172	G5 box; other site
240292007173	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
240292007174	Translation-initiation factor 2; Region: IF-2; pfam11987
240292007175	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
240292007176	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
240292007177	putative RNA binding cleft [nucleotide binding]; other site
240292007178	transcription elongation factor NusA; Provisional; Region: nusA; PRK12329
240292007179	NusA N-terminal domain; Region: NusA_N; pfam08529
240292007180	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
240292007181	RNA binding site [nucleotide binding]; other site
240292007182	homodimer interface [polypeptide binding]; other site
240292007183	NusA-like KH domain; Region: KH_5; pfam13184
240292007184	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
240292007185	G-X-X-G motif; other site
240292007186	ribosome maturation protein RimP; Reviewed; Region: PRK00092
240292007187	Sm and related proteins; Region: Sm_like; cl00259
240292007188	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
240292007189	putative oligomer interface [polypeptide binding]; other site
240292007190	putative RNA binding site [nucleotide binding]; other site
240292007191	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292007192	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292007193	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292007194	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
240292007195	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
240292007196	active site
240292007197	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007198	putative active site [active]
240292007199	DNA repair protein RadA; Provisional; Region: PRK11823
240292007200	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
240292007201	Walker A motif/ATP binding site; other site
240292007202	ATP binding site [chemical binding]; other site
240292007203	Walker B motif; other site
240292007204	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
240292007205	Ycf27; Reviewed; Region: orf27; CHL00148
240292007206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292007207	active site
240292007208	phosphorylation site [posttranslational modification]
240292007209	intermolecular recognition site; other site
240292007210	dimerization interface [polypeptide binding]; other site
240292007211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292007212	DNA binding site [nucleotide binding]
240292007213	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
240292007214	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007215	putative active site [active]
240292007216	Protein of unknown function (DUF456); Region: DUF456; cl01069
240292007217	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
240292007218	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292007219	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292007220	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292007221	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292007222	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
240292007223	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
240292007224	catalytic site [active]
240292007225	Transposase domain (DUF772); Region: DUF772; pfam05598
240292007226	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292007227	HEAT repeats; Region: HEAT_2; pfam13646
240292007228	HEAT repeats; Region: HEAT_2; pfam13646
240292007229	FOG: CBS domain [General function prediction only]; Region: COG0517
240292007230	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
240292007231	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
240292007232	active site
240292007233	8-oxo-dGMP binding site [chemical binding]; other site
240292007234	nudix motif; other site
240292007235	metal binding site [ion binding]; metal-binding site
240292007236	Protein of unknown function (DUF760); Region: DUF760; pfam05542
240292007237	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
240292007238	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292007239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292007240	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292007241	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292007242	DNA binding residues [nucleotide binding]
240292007243	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
240292007244	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240292007245	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
240292007246	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
240292007247	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240292007248	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292007249	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
240292007250	IMP binding site; other site
240292007251	dimer interface [polypeptide binding]; other site
240292007252	interdomain contacts; other site
240292007253	partial ornithine binding site; other site
240292007254	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
240292007255	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
240292007256	dimerization interface [polypeptide binding]; other site
240292007257	DPS ferroxidase diiron center [ion binding]; other site
240292007258	ion pore; other site
240292007259	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
240292007260	dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334
240292007261	NAD binding site [chemical binding]; other site
240292007262	homodimer interface [polypeptide binding]; other site
240292007263	active site
240292007264	deoxyhypusine synthase-like protein; Provisional; Region: PRK00770
240292007265	deoxyhypusine synthase; Region: dhys; TIGR00321
240292007266	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
240292007267	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
240292007268	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
240292007269	homodimer interface [polypeptide binding]; other site
240292007270	Walker A motif; other site
240292007271	ATP binding site [chemical binding]; other site
240292007272	hydroxycobalamin binding site [chemical binding]; other site
240292007273	Walker B motif; other site
240292007274	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
240292007275	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
240292007276	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292007277	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292007278	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292007279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292007280	motif II; other site
240292007281	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292007282	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
240292007283	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240292007284	Walker A/P-loop; other site
240292007285	ATP binding site [chemical binding]; other site
240292007286	Q-loop/lid; other site
240292007287	ABC transporter signature motif; other site
240292007288	Walker B; other site
240292007289	D-loop; other site
240292007290	H-loop/switch region; other site
240292007291	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
240292007292	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292007293	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292007294	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
240292007295	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292007296	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292007297	RNA polymerase sigma factor; Validated; Region: PRK05949
240292007298	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240292007299	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292007300	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292007301	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292007302	DNA binding residues [nucleotide binding]
240292007303	HAS barrel domain; Region: HAS-barrel; pfam09378
240292007304	HerA helicase [Replication, recombination, and repair]; Region: COG0433
240292007305	Domain of unknown function DUF87; Region: DUF87; pfam01935
240292007306	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292007307	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
240292007308	C-terminal domain interface [polypeptide binding]; other site
240292007309	GSH binding site (G-site) [chemical binding]; other site
240292007310	dimer interface [polypeptide binding]; other site
240292007311	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
240292007312	N-terminal domain interface [polypeptide binding]; other site
240292007313	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292007314	Fasciclin domain; Region: Fasciclin; pfam02469
240292007315	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
240292007316	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
240292007317	putative rRNA binding site [nucleotide binding]; other site
240292007318	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
240292007319	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
240292007320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292007321	catalytic residue [active]
240292007322	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240292007323	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
240292007324	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240292007325	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
240292007326	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
240292007327	catalytic site [active]
240292007328	putative active site [active]
240292007329	putative substrate binding site [chemical binding]; other site
240292007330	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240292007331	active site residue [active]
240292007332	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292007333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292007334	Walker A motif; other site
240292007335	ATP binding site [chemical binding]; other site
240292007336	Walker B motif; other site
240292007337	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292007338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292007339	active site
240292007340	phosphorylation site [posttranslational modification]
240292007341	intermolecular recognition site; other site
240292007342	dimerization interface [polypeptide binding]; other site
240292007343	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292007344	DNA binding site [nucleotide binding]
240292007345	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
240292007346	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
240292007347	cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876
240292007348	Ycf39; Provisional; Region: ycf39; CHL00194
240292007349	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
240292007350	NAD(P) binding site [chemical binding]; other site
240292007351	putative active site [active]
240292007352	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
240292007353	ATP-NAD kinase; Region: NAD_kinase; pfam01513
240292007354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292007355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292007356	active site
240292007357	phosphorylation site [posttranslational modification]
240292007358	intermolecular recognition site; other site
240292007359	dimerization interface [polypeptide binding]; other site
240292007360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292007361	DNA binding site [nucleotide binding]
240292007362	Uncharacterized conserved protein [Function unknown]; Region: COG1430
240292007363	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
240292007364	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
240292007365	active site
240292007366	ribulose/triose binding site [chemical binding]; other site
240292007367	phosphate binding site [ion binding]; other site
240292007368	substrate (anthranilate) binding pocket [chemical binding]; other site
240292007369	product (indole) binding pocket [chemical binding]; other site
240292007370	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
240292007371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292007372	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240292007373	Uncharacterized conserved protein [Function unknown]; Region: COG4715
240292007374	SWIM zinc finger; Region: SWIM; pfam04434
240292007375	S-layer homology domain; Region: SLH; pfam00395
240292007376	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292007377	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
240292007378	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240292007379	DNA-binding site [nucleotide binding]; DNA binding site
240292007380	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292007381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292007382	homodimer interface [polypeptide binding]; other site
240292007383	catalytic residue [active]
240292007384	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
240292007385	Transposase domain (DUF772); Region: DUF772; pfam05598
240292007386	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292007387	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
240292007388	YcfA-like protein; Region: YcfA; pfam07927
240292007389	magnesium chelatase, H subunit; Region: BchH; TIGR02025
240292007390	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
240292007391	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292007392	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292007393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292007394	Walker A/P-loop; other site
240292007395	ATP binding site [chemical binding]; other site
240292007396	Q-loop/lid; other site
240292007397	ABC transporter signature motif; other site
240292007398	Walker B; other site
240292007399	D-loop; other site
240292007400	H-loop/switch region; other site
240292007401	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292007402	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292007403	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240292007404	Walker A/P-loop; other site
240292007405	ATP binding site [chemical binding]; other site
240292007406	Q-loop/lid; other site
240292007407	ABC transporter signature motif; other site
240292007408	Walker B; other site
240292007409	D-loop; other site
240292007410	H-loop/switch region; other site
240292007411	Uncharacterized conserved protein [Function unknown]; Region: COG1432
240292007412	LabA_like proteins; Region: LabA; cd10911
240292007413	putative metal binding site [ion binding]; other site
240292007414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292007415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292007416	active site
240292007417	phosphorylation site [posttranslational modification]
240292007418	intermolecular recognition site; other site
240292007419	dimerization interface [polypeptide binding]; other site
240292007420	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292007421	DNA binding site [nucleotide binding]
240292007422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292007423	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292007424	dimerization interface [polypeptide binding]; other site
240292007425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292007426	dimer interface [polypeptide binding]; other site
240292007427	phosphorylation site [posttranslational modification]
240292007428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292007429	ATP binding site [chemical binding]; other site
240292007430	Mg2+ binding site [ion binding]; other site
240292007431	G-X-G motif; other site
240292007432	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
240292007433	dimer interface [polypeptide binding]; other site
240292007434	active site
240292007435	aspartate-rich active site metal binding site; other site
240292007436	allosteric magnesium binding site [ion binding]; other site
240292007437	Schiff base residues; other site
240292007438	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
240292007439	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
240292007440	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
240292007441	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292007442	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
240292007443	homodecamer interface [polypeptide binding]; other site
240292007444	GTP cyclohydrolase I; Provisional; Region: PLN03044
240292007445	active site
240292007446	putative catalytic site residues [active]
240292007447	zinc binding site [ion binding]; other site
240292007448	GTP-CH-I/GFRP interaction surface; other site
240292007449	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292007450	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
240292007451	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
240292007452	ATP binding site [chemical binding]; other site
240292007453	Mg++ binding site [ion binding]; other site
240292007454	motif III; other site
240292007455	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292007456	nucleotide binding region [chemical binding]; other site
240292007457	ATP-binding site [chemical binding]; other site
240292007458	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
240292007459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292007460	dimer interface [polypeptide binding]; other site
240292007461	phosphorylation site [posttranslational modification]
240292007462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292007463	ATP binding site [chemical binding]; other site
240292007464	Mg2+ binding site [ion binding]; other site
240292007465	G-X-G motif; other site
240292007466	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292007467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292007468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292007469	Walker A/P-loop; other site
240292007470	ATP binding site [chemical binding]; other site
240292007471	Q-loop/lid; other site
240292007472	ABC transporter signature motif; other site
240292007473	Walker B; other site
240292007474	D-loop; other site
240292007475	H-loop/switch region; other site
240292007476	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
240292007477	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
240292007478	NAD binding site [chemical binding]; other site
240292007479	homodimer interface [polypeptide binding]; other site
240292007480	active site
240292007481	substrate binding site [chemical binding]; other site
240292007482	Uncharacterized conserved protein [Function unknown]; Region: COG2836
240292007483	Predicted membrane protein [Function unknown]; Region: COG2717
240292007484	M28 Zn-Peptidases; Region: M28_like_1; cd05640
240292007485	Peptidase family M28; Region: Peptidase_M28; pfam04389
240292007486	metal binding site [ion binding]; metal-binding site
240292007487	thymidylate kinase; Validated; Region: tmk; PRK00698
240292007488	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
240292007489	TMP-binding site; other site
240292007490	ATP-binding site [chemical binding]; other site
240292007491	DNA polymerase III subunit delta'; Validated; Region: PRK07399
240292007492	AAA ATPase domain; Region: AAA_16; pfam13191
240292007493	DNA polymerase III subunit delta'; Validated; Region: PRK08485
240292007494	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
240292007495	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
240292007496	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
240292007497	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
240292007498	active site
240292007499	(T/H)XGH motif; other site
240292007500	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
240292007501	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
240292007502	active site
240292007503	SAM binding site [chemical binding]; other site
240292007504	homodimer interface [polypeptide binding]; other site
240292007505	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
240292007506	hypothetical protein; Provisional; Region: PRK09256
240292007507	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
240292007508	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
240292007509	putative active site [active]
240292007510	putative metal binding residues [ion binding]; other site
240292007511	signature motif; other site
240292007512	putative dimer interface [polypeptide binding]; other site
240292007513	putative phosphate binding site [ion binding]; other site
240292007514	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
240292007515	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292007516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292007517	putative substrate translocation pore; other site
240292007518	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
240292007519	MarR family; Region: MarR; pfam01047
240292007520	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292007521	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240292007522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292007523	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292007524	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292007525	active site
240292007526	ATP binding site [chemical binding]; other site
240292007527	substrate binding site [chemical binding]; other site
240292007528	activation loop (A-loop); other site
240292007529	AAA ATPase domain; Region: AAA_16; pfam13191
240292007530	Predicted ATPase [General function prediction only]; Region: COG3899
240292007531	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292007532	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292007533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292007534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292007535	dimer interface [polypeptide binding]; other site
240292007536	phosphorylation site [posttranslational modification]
240292007537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292007538	ATP binding site [chemical binding]; other site
240292007539	Mg2+ binding site [ion binding]; other site
240292007540	G-X-G motif; other site
240292007541	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240292007542	Cytochrome P450; Region: p450; pfam00067
240292007543	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
240292007544	substrate binding pocket [chemical binding]; other site
240292007545	substrate-Mg2+ binding site; other site
240292007546	aspartate-rich region 1; other site
240292007547	active site lid residues [active]
240292007548	aspartate-rich region 2; other site
240292007549	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292007550	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292007551	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
240292007552	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
240292007553	active site
240292007554	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
240292007555	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240292007556	substrate binding site [chemical binding]; other site
240292007557	ATP binding site [chemical binding]; other site
240292007558	Predicted methyltransferases [General function prediction only]; Region: COG0313
240292007559	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
240292007560	putative SAM binding site [chemical binding]; other site
240292007561	putative homodimer interface [polypeptide binding]; other site
240292007562	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
240292007563	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
240292007564	trmE is a tRNA modification GTPase; Region: trmE; cd04164
240292007565	G1 box; other site
240292007566	GTP/Mg2+ binding site [chemical binding]; other site
240292007567	Switch I region; other site
240292007568	G2 box; other site
240292007569	Switch II region; other site
240292007570	G3 box; other site
240292007571	G4 box; other site
240292007572	G5 box; other site
240292007573	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
240292007574	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
240292007575	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292007576	putative active site [active]
240292007577	putative metal binding site [ion binding]; other site
240292007578	quinolinate synthetase; Provisional; Region: PRK09375
240292007579	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
240292007580	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240292007581	Zn2+ binding site [ion binding]; other site
240292007582	Mg2+ binding site [ion binding]; other site
240292007583	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
240292007584	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
240292007585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292007586	active site
240292007587	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292007588	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292007589	active site
240292007590	ATP binding site [chemical binding]; other site
240292007591	substrate binding site [chemical binding]; other site
240292007592	activation loop (A-loop); other site
240292007593	AAA domain; Region: AAA_26; pfam13500
240292007594	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
240292007595	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
240292007596	DRTGG domain; Region: DRTGG; pfam07085
240292007597	Predicted membrane protein [Function unknown]; Region: COG3686
240292007598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
240292007599	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
240292007600	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292007601	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
240292007602	putative C-terminal domain interface [polypeptide binding]; other site
240292007603	putative GSH binding site (G-site) [chemical binding]; other site
240292007604	putative dimer interface [polypeptide binding]; other site
240292007605	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
240292007606	dimer interface [polypeptide binding]; other site
240292007607	N-terminal domain interface [polypeptide binding]; other site
240292007608	substrate binding pocket (H-site) [chemical binding]; other site
240292007609	TPR repeat; Region: TPR_11; pfam13414
240292007610	TPR repeat; Region: TPR_11; pfam13414
240292007611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292007612	binding surface
240292007613	TPR motif; other site
240292007614	TPR repeat; Region: TPR_11; pfam13414
240292007615	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
240292007616	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240292007617	D-xylulose kinase; Region: XylB; TIGR01312
240292007618	nucleotide binding site [chemical binding]; other site
240292007619	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240292007620	nucleotide binding site [chemical binding]; other site
240292007621	muropeptide transporter; Reviewed; Region: ampG; PRK11902
240292007622	muropeptide transporter; Validated; Region: ampG; cl17669
240292007623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
240292007624	putative integral membrane protein TIGR02587; Region: TIGR02587
240292007625	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
240292007626	TIGR02588 family protein; Region: TIGR02588
240292007627	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
240292007628	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
240292007629	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292007630	Fasciclin domain; Region: Fasciclin; pfam02469
240292007631	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
240292007632	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
240292007633	active site
240292007634	homodimer interface [polypeptide binding]; other site
240292007635	catalytic site [active]
240292007636	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
240292007637	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
240292007638	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
240292007639	active site
240292007640	catalytic triad [active]
240292007641	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
240292007642	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
240292007643	ligand binding site; other site
240292007644	oligomer interface; other site
240292007645	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
240292007646	dimer interface [polypeptide binding]; other site
240292007647	N-terminal domain interface [polypeptide binding]; other site
240292007648	sulfate 1 binding site; other site
240292007649	Predicted kinase [General function prediction only]; Region: COG4639
240292007650	AAA domain; Region: AAA_17; pfam13207
240292007651	chaperone protein DnaJ; Provisional; Region: PRK14299
240292007652	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292007653	HSP70 interaction site [polypeptide binding]; other site
240292007654	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240292007655	substrate binding site [polypeptide binding]; other site
240292007656	dimer interface [polypeptide binding]; other site
240292007657	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
240292007658	putative catalytic residues [active]
240292007659	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240292007660	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
240292007661	dimer interface [polypeptide binding]; other site
240292007662	decamer (pentamer of dimers) interface [polypeptide binding]; other site
240292007663	catalytic triad [active]
240292007664	peroxidatic and resolving cysteines [active]
240292007665	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
240292007666	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
240292007667	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
240292007668	P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678
240292007669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240292007670	Histidine kinase; Region: HisKA_3; pfam07730
240292007671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292007672	ATP binding site [chemical binding]; other site
240292007673	Mg2+ binding site [ion binding]; other site
240292007674	G-X-G motif; other site
240292007675	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292007676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292007677	active site
240292007678	phosphorylation site [posttranslational modification]
240292007679	intermolecular recognition site; other site
240292007680	dimerization interface [polypeptide binding]; other site
240292007681	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292007682	DNA binding residues [nucleotide binding]
240292007683	dimerization interface [polypeptide binding]; other site
240292007684	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
240292007685	nucleoside/Zn binding site; other site
240292007686	dimer interface [polypeptide binding]; other site
240292007687	catalytic motif [active]
240292007688	Ion transport protein; Region: Ion_trans; pfam00520
240292007689	Ion channel; Region: Ion_trans_2; pfam07885
240292007690	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292007691	Double zinc ribbon; Region: DZR; pfam12773
240292007692	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
240292007693	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240292007694	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292007695	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292007696	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
240292007697	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
240292007698	putative valine binding site [chemical binding]; other site
240292007699	dimer interface [polypeptide binding]; other site
240292007700	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
240292007701	hydrolase, alpha/beta fold family protein; Region: PLN02824
240292007702	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
240292007703	translation initiation factor 3; Provisional; Region: infC; CHL00199
240292007704	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
240292007705	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
240292007706	TLC ATP/ADP transporter; Region: TLC; cl03940
240292007707	HEAT repeats; Region: HEAT_2; pfam13646
240292007708	Predicted membrane protein [Function unknown]; Region: COG1808
240292007709	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
240292007710	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
240292007711	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
240292007712	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240292007713	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
240292007714	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
240292007715	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292007716	Walker A/P-loop; other site
240292007717	ATP binding site [chemical binding]; other site
240292007718	Q-loop/lid; other site
240292007719	ABC transporter signature motif; other site
240292007720	Walker B; other site
240292007721	D-loop; other site
240292007722	H-loop/switch region; other site
240292007723	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240292007724	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292007725	Walker A/P-loop; other site
240292007726	ATP binding site [chemical binding]; other site
240292007727	Q-loop/lid; other site
240292007728	ABC transporter signature motif; other site
240292007729	Walker B; other site
240292007730	D-loop; other site
240292007731	H-loop/switch region; other site
240292007732	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240292007733	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240292007734	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240292007735	dimer interface [polypeptide binding]; other site
240292007736	ssDNA binding site [nucleotide binding]; other site
240292007737	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240292007738	tellurium resistance terB-like protein; Region: terB_like; cd07177
240292007739	metal binding site [ion binding]; metal-binding site
240292007740	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
240292007741	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
240292007742	Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513
240292007743	Fatty acid desaturase; Region: FA_desaturase; pfam00487
240292007744	putative di-iron ligands [ion binding]; other site
240292007745	hypothetical protein; Provisional; Region: PRK06185
240292007746	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240292007747	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
240292007748	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
240292007749	Walker A/P-loop; other site
240292007750	ATP binding site [chemical binding]; other site
240292007751	Q-loop/lid; other site
240292007752	ABC transporter signature motif; other site
240292007753	Walker B; other site
240292007754	D-loop; other site
240292007755	H-loop/switch region; other site
240292007756	TOBE domain; Region: TOBE_2; pfam08402
240292007757	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
240292007758	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
240292007759	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
240292007760	GDP-binding site [chemical binding]; other site
240292007761	ACT binding site; other site
240292007762	IMP binding site; other site
240292007763	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
240292007764	5S rRNA interface [nucleotide binding]; other site
240292007765	CTC domain interface [polypeptide binding]; other site
240292007766	L16 interface [polypeptide binding]; other site
240292007767	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240292007768	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
240292007769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
240292007770	Predicted kinase [General function prediction only]; Region: COG0645
240292007771	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
240292007772	ATP-binding site [chemical binding]; other site
240292007773	Gluconate-6-phosphate binding site [chemical binding]; other site
240292007774	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
240292007775	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
240292007776	generic binding surface II; other site
240292007777	ssDNA binding site; other site
240292007778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292007779	ATP binding site [chemical binding]; other site
240292007780	putative Mg++ binding site [ion binding]; other site
240292007781	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292007782	nucleotide binding region [chemical binding]; other site
240292007783	ATP-binding site [chemical binding]; other site
240292007784	elongation factor Ts; Provisional; Region: tsf; PRK09377
240292007785	UBA/TS-N domain; Region: UBA; pfam00627
240292007786	Elongation factor TS; Region: EF_TS; pfam00889
240292007787	Elongation factor TS; Region: EF_TS; pfam00889
240292007788	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
240292007789	rRNA interaction site [nucleotide binding]; other site
240292007790	S8 interaction site; other site
240292007791	putative laminin-1 binding site; other site
240292007792	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292007793	AAA domain; Region: AAA_21; pfam13304
240292007794	Walker A/P-loop; other site
240292007795	ATP binding site [chemical binding]; other site
240292007796	AAA domain; Region: AAA_21; pfam13304
240292007797	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
240292007798	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292007799	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
240292007800	Probable Catalytic site; other site
240292007801	metal-binding site
240292007802	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
240292007803	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
240292007804	argininosuccinate synthase; Provisional; Region: PRK13820
240292007805	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
240292007806	ANP binding site [chemical binding]; other site
240292007807	Substrate Binding Site II [chemical binding]; other site
240292007808	Substrate Binding Site I [chemical binding]; other site
240292007809	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
240292007810	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
240292007811	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292007812	anti sigma factor interaction site; other site
240292007813	regulatory phosphorylation site [posttranslational modification]; other site
240292007814	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
240292007815	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
240292007816	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
240292007817	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
240292007818	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
240292007819	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
240292007820	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
240292007821	dimer interface [polypeptide binding]; other site
240292007822	active site
240292007823	glycine-pyridoxal phosphate binding site [chemical binding]; other site
240292007824	folate binding site [chemical binding]; other site
240292007825	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
240292007826	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
240292007827	Mg++ binding site [ion binding]; other site
240292007828	putative catalytic motif [active]
240292007829	substrate binding site [chemical binding]; other site
240292007830	competence damage-inducible protein A; Provisional; Region: PRK00549
240292007831	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
240292007832	putative MPT binding site; other site
240292007833	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
240292007834	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007835	putative active site [active]
240292007836	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
240292007837	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
240292007838	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
240292007839	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
240292007840	substrate binding site [chemical binding]; other site
240292007841	active site
240292007842	catalytic residues [active]
240292007843	heterodimer interface [polypeptide binding]; other site
240292007844	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292007845	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292007846	active site
240292007847	ATP binding site [chemical binding]; other site
240292007848	substrate binding site [chemical binding]; other site
240292007849	activation loop (A-loop); other site
240292007850	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
240292007851	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
240292007852	Predicted GTPase [General function prediction only]; Region: COG3596
240292007853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292007854	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292007855	G1 box; other site
240292007856	Walker A/P-loop; other site
240292007857	GTP/Mg2+ binding site [chemical binding]; other site
240292007858	ATP binding site [chemical binding]; other site
240292007859	G2 box; other site
240292007860	Switch I region; other site
240292007861	G3 box; other site
240292007862	Switch II region; other site
240292007863	G4 box; other site
240292007864	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240292007865	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
240292007866	Cl- selectivity filter; other site
240292007867	Cl- binding residues [ion binding]; other site
240292007868	pore gating glutamate residue; other site
240292007869	dimer interface [polypeptide binding]; other site
240292007870	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
240292007871	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
240292007872	AMIN domain; Region: AMIN; pfam11741
240292007873	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
240292007874	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
240292007875	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292007876	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
240292007877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292007878	dimer interface [polypeptide binding]; other site
240292007879	conserved gate region; other site
240292007880	putative PBP binding loops; other site
240292007881	ABC-ATPase subunit interface; other site
240292007882	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
240292007883	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
240292007884	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
240292007885	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
240292007886	NADP binding site [chemical binding]; other site
240292007887	active site
240292007888	putative substrate binding site [chemical binding]; other site
240292007889	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
240292007890	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
240292007891	homotetramer interface [polypeptide binding]; other site
240292007892	NADP-binding site; other site
240292007893	substrate binding site [chemical binding]; other site
240292007894	homodimer interface [polypeptide binding]; other site
240292007895	active site
240292007896	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292007897	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292007898	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
240292007899	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292007900	putative ADP-binding pocket [chemical binding]; other site
240292007901	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292007902	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
240292007903	putative NAD(P) binding site [chemical binding]; other site
240292007904	active site
240292007905	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
240292007906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
240292007907	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240292007908	Cytochrome P450; Region: p450; pfam00067
240292007909	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292007910	AAA ATPase domain; Region: AAA_16; pfam13191
240292007911	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292007912	structural tetrad; other site
240292007913	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292007914	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292007915	structural tetrad; other site
240292007916	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292007917	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292007918	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
240292007919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292007920	TPR motif; other site
240292007921	binding surface
240292007922	MEKHLA domain; Region: MEKHLA; pfam08670
240292007923	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
240292007924	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292007925	CHASE2 domain; Region: CHASE2; pfam05226
240292007926	Protein kinase domain; Region: Pkinase; pfam00069
240292007927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292007928	active site
240292007929	ATP binding site [chemical binding]; other site
240292007930	substrate binding site [chemical binding]; other site
240292007931	activation loop (A-loop); other site
240292007932	Uncharacterized conserved protein [Function unknown]; Region: COG1432
240292007933	LabA_like proteins; Region: LabA; cd10911
240292007934	putative metal binding site [ion binding]; other site
240292007935	2-isopropylmalate synthase; Validated; Region: PRK00915
240292007936	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
240292007937	active site
240292007938	catalytic residues [active]
240292007939	metal binding site [ion binding]; metal-binding site
240292007940	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
240292007941	diaminopimelate epimerase; Provisional; Region: PRK13577
240292007942	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240292007943	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240292007944	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
240292007945	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292007946	ATP binding site [chemical binding]; other site
240292007947	putative Mg++ binding site [ion binding]; other site
240292007948	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292007949	nucleotide binding region [chemical binding]; other site
240292007950	ATP-binding site [chemical binding]; other site
240292007951	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
240292007952	AAA domain; Region: AAA_17; pfam13207
240292007953	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
240292007954	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
240292007955	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
240292007956	dimer interface [polypeptide binding]; other site
240292007957	motif 1; other site
240292007958	active site
240292007959	motif 2; other site
240292007960	motif 3; other site
240292007961	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
240292007962	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
240292007963	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
240292007964	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
240292007965	active site
240292007966	Riboflavin kinase; Region: Flavokinase; pfam01687
240292007967	MoxR-like ATPases [General function prediction only]; Region: COG0714
240292007968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292007969	ATP binding site [chemical binding]; other site
240292007970	Walker A motif; other site
240292007971	Walker B motif; other site
240292007972	arginine finger; other site
240292007973	Dihaem cytochrome c; Region: DHC; pfam09626
240292007974	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
240292007975	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
240292007976	ATP binding site [chemical binding]; other site
240292007977	putative Mg++ binding site [ion binding]; other site
240292007978	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
240292007979	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
240292007980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292007981	ATP binding site [chemical binding]; other site
240292007982	putative Mg++ binding site [ion binding]; other site
240292007983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292007984	nucleotide binding region [chemical binding]; other site
240292007985	ATP-binding site [chemical binding]; other site
240292007986	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292007987	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292007988	active site
240292007989	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007990	putative active site [active]
240292007991	aspartate aminotransferase; Provisional; Region: PRK05764
240292007992	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292007993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292007994	homodimer interface [polypeptide binding]; other site
240292007995	catalytic residue [active]
240292007996	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292007997	putative active site [active]
240292007998	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
240292007999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
240292008000	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292008001	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
240292008002	putative metal binding site; other site
240292008003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292008004	TPR motif; other site
240292008005	binding surface
240292008006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292008007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292008008	binding surface
240292008009	TPR repeat; Region: TPR_11; pfam13414
240292008010	TPR motif; other site
240292008011	TPR repeat; Region: TPR_11; pfam13414
240292008012	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
240292008013	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
240292008014	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
240292008015	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
240292008016	protein I interface; other site
240292008017	D2 interface; other site
240292008018	protein T interface; other site
240292008019	chlorophyll binding site; other site
240292008020	beta carotene binding site; other site
240292008021	pheophytin binding site; other site
240292008022	manganese-stabilizing polypeptide interface; other site
240292008023	CP43 interface; other site
240292008024	protein L interface; other site
240292008025	oxygen evolving complex binding site; other site
240292008026	bromide binding site; other site
240292008027	quinone binding site; other site
240292008028	Fe binding site [ion binding]; other site
240292008029	core light harvesting interface; other site
240292008030	cytochrome b559 alpha subunit interface; other site
240292008031	cytochrome c-550 interface; other site
240292008032	protein J interface; other site
240292008033	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
240292008034	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
240292008035	active site
240292008036	catalytic triad [active]
240292008037	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
240292008038	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
240292008039	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292008040	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240292008041	putative acyl-acceptor binding pocket; other site
240292008042	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
240292008043	nucleoside/Zn binding site; other site
240292008044	dimer interface [polypeptide binding]; other site
240292008045	catalytic motif [active]
240292008046	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
240292008047	GSH binding site [chemical binding]; other site
240292008048	catalytic residues [active]
240292008049	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
240292008050	NADH(P)-binding; Region: NAD_binding_10; pfam13460
240292008051	NAD(P) binding site [chemical binding]; other site
240292008052	putative active site [active]
240292008053	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
240292008054	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292008055	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292008056	structural tetrad; other site
240292008057	Cache domain; Region: Cache_1; pfam02743
240292008058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292008060	dimerization interface [polypeptide binding]; other site
240292008061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008062	dimer interface [polypeptide binding]; other site
240292008063	phosphorylation site [posttranslational modification]
240292008064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008065	ATP binding site [chemical binding]; other site
240292008066	Mg2+ binding site [ion binding]; other site
240292008067	G-X-G motif; other site
240292008068	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008070	active site
240292008071	phosphorylation site [posttranslational modification]
240292008072	intermolecular recognition site; other site
240292008073	dimerization interface [polypeptide binding]; other site
240292008074	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008076	active site
240292008077	phosphorylation site [posttranslational modification]
240292008078	intermolecular recognition site; other site
240292008079	dimerization interface [polypeptide binding]; other site
240292008080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292008082	dimer interface [polypeptide binding]; other site
240292008083	phosphorylation site [posttranslational modification]
240292008084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008085	ATP binding site [chemical binding]; other site
240292008086	Mg2+ binding site [ion binding]; other site
240292008087	G-X-G motif; other site
240292008088	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008090	active site
240292008091	phosphorylation site [posttranslational modification]
240292008092	intermolecular recognition site; other site
240292008093	dimerization interface [polypeptide binding]; other site
240292008094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008095	ATP binding site [chemical binding]; other site
240292008096	Mg2+ binding site [ion binding]; other site
240292008097	G-X-G motif; other site
240292008098	Uncharacterized conserved protein [Function unknown]; Region: COG3287
240292008099	FIST N domain; Region: FIST; pfam08495
240292008100	FIST C domain; Region: FIST_C; pfam10442
240292008101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008103	dimer interface [polypeptide binding]; other site
240292008104	phosphorylation site [posttranslational modification]
240292008105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008106	ATP binding site [chemical binding]; other site
240292008107	Mg2+ binding site [ion binding]; other site
240292008108	G-X-G motif; other site
240292008109	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
240292008110	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292008111	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
240292008112	NADPH bind site [chemical binding]; other site
240292008113	putative FMN binding site [chemical binding]; other site
240292008114	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
240292008115	putative FMN binding site [chemical binding]; other site
240292008116	NADPH bind site [chemical binding]; other site
240292008117	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
240292008118	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
240292008119	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
240292008120	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
240292008121	homodimer interface [polypeptide binding]; other site
240292008122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292008123	catalytic residue [active]
240292008124	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
240292008125	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
240292008126	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292008127	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292008128	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240292008129	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
240292008130	Cl- selectivity filter; other site
240292008131	Cl- binding residues [ion binding]; other site
240292008132	pore gating glutamate residue; other site
240292008133	dimer interface [polypeptide binding]; other site
240292008134	H+/Cl- coupling transport residue; other site
240292008135	FOG: CBS domain [General function prediction only]; Region: COG0517
240292008136	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292008137	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
240292008138	Ligand Binding Site [chemical binding]; other site
240292008139	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292008140	Ligand Binding Site [chemical binding]; other site
240292008141	Domain of unknown function (DUF897); Region: DUF897; pfam05982
240292008142	Nitrogen regulatory protein P-II; Region: P-II; cl00412
240292008143	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
240292008144	active site clefts [active]
240292008145	zinc binding site [ion binding]; other site
240292008146	dimer interface [polypeptide binding]; other site
240292008147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
240292008148	conserved hypothetical protein; Region: TIGR03492
240292008149	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292008150	Fasciclin domain; Region: Fasciclin; pfam02469
240292008151	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
240292008152	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
240292008153	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
240292008154	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
240292008155	FMN binding site [chemical binding]; other site
240292008156	active site
240292008157	catalytic residues [active]
240292008158	substrate binding site [chemical binding]; other site
240292008159	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240292008160	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240292008161	DNA binding site [nucleotide binding]
240292008162	domain linker motif; other site
240292008163	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240292008164	dimerization interface [polypeptide binding]; other site
240292008165	ligand binding site [chemical binding]; other site
240292008166	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
240292008167	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
240292008168	putative ligand binding site [chemical binding]; other site
240292008169	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
240292008170	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
240292008171	Walker A/P-loop; other site
240292008172	ATP binding site [chemical binding]; other site
240292008173	Q-loop/lid; other site
240292008174	ABC transporter signature motif; other site
240292008175	Walker B; other site
240292008176	D-loop; other site
240292008177	H-loop/switch region; other site
240292008178	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
240292008179	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
240292008180	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
240292008181	TM-ABC transporter signature motif; other site
240292008182	S-layer homology domain; Region: SLH; pfam00395
240292008183	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292008184	conjugal transfer protein TraL; Provisional; Region: PRK13886
240292008185	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008187	dimer interface [polypeptide binding]; other site
240292008188	phosphorylation site [posttranslational modification]
240292008189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008190	ATP binding site [chemical binding]; other site
240292008191	Mg2+ binding site [ion binding]; other site
240292008192	G-X-G motif; other site
240292008193	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
240292008194	catalytic core [active]
240292008195	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
240292008196	KGK domain; Region: KGK; pfam08872
240292008197	Homeodomain-like domain; Region: HTH_23; pfam13384
240292008198	Winged helix-turn helix; Region: HTH_29; pfam13551
240292008199	Winged helix-turn helix; Region: HTH_33; pfam13592
240292008200	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292008201	Caspase domain; Region: Peptidase_C14; pfam00656
240292008202	NACHT domain; Region: NACHT; pfam05729
240292008203	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292008204	structural tetrad; other site
240292008205	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292008206	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292008207	structural tetrad; other site
240292008208	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292008209	structural tetrad; other site
240292008210	Caspase domain; Region: Peptidase_C14; pfam00656
240292008211	AAA ATPase domain; Region: AAA_16; pfam13191
240292008212	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292008213	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292008214	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292008215	structural tetrad; other site
240292008216	WD domain, G-beta repeat; Region: WD40; pfam00400
240292008217	Homeodomain-like domain; Region: HTH_23; pfam13384
240292008218	Winged helix-turn helix; Region: HTH_29; pfam13551
240292008219	Integrase core domain; Region: rve; pfam00665
240292008220	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292008221	Bacterial TniB protein; Region: TniB; pfam05621
240292008222	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292008223	TniQ; Region: TniQ; pfam06527
240292008224	DEAD-like helicases superfamily; Region: DEXDc; smart00487
240292008225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292008226	ATP binding site [chemical binding]; other site
240292008227	putative Mg++ binding site [ion binding]; other site
240292008228	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
240292008229	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292008230	nucleotide binding region [chemical binding]; other site
240292008231	ATP-binding site [chemical binding]; other site
240292008232	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
240292008233	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
240292008234	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
240292008235	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292008236	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
240292008237	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
240292008238	Protein of unknown function (DUF499); Region: DUF499; pfam04465
240292008239	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292008240	non-specific DNA binding site [nucleotide binding]; other site
240292008241	salt bridge; other site
240292008242	sequence-specific DNA binding site [nucleotide binding]; other site
240292008243	ornithine carbamoyltransferase; Provisional; Region: PRK00779
240292008244	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
240292008245	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
240292008246	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
240292008247	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
240292008248	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
240292008249	Catalytic site [active]
240292008250	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
240292008251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292008252	ATP binding site [chemical binding]; other site
240292008253	putative Mg++ binding site [ion binding]; other site
240292008254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292008255	nucleotide binding region [chemical binding]; other site
240292008256	ATP-binding site [chemical binding]; other site
240292008257	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
240292008258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008259	Walker A/P-loop; other site
240292008260	ATP binding site [chemical binding]; other site
240292008261	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292008262	putative active site [active]
240292008263	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
240292008264	DNA-sulfur modification-associated; Region: DndB; cl17621
240292008265	GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465
240292008266	DGQHR domain; Region: DGQHR; TIGR03187
240292008267	DNA-sulfur modification-associated; Region: DndB; cl17621
240292008268	hypothetical protein; Provisional; Region: PRK06850
240292008269	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240292008270	Active Sites [active]
240292008271	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
240292008272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008273	Walker A/P-loop; other site
240292008274	ATP binding site [chemical binding]; other site
240292008275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008276	ABC transporter signature motif; other site
240292008277	Walker B; other site
240292008278	D-loop; other site
240292008279	H-loop/switch region; other site
240292008280	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
240292008281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292008282	binding surface
240292008283	TPR motif; other site
240292008284	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240292008285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292008286	binding surface
240292008287	TPR motif; other site
240292008288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292008289	binding surface
240292008290	TPR motif; other site
240292008291	CHAT domain; Region: CHAT; cl17868
240292008292	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
240292008293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292008294	Walker A motif; other site
240292008295	ATP binding site [chemical binding]; other site
240292008296	Walker B motif; other site
240292008297	arginine finger; other site
240292008298	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
240292008299	hypothetical protein; Provisional; Region: PRK02237
240292008300	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
240292008301	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
240292008302	DXD motif; other site
240292008303	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
240292008304	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
240292008305	metal binding site [ion binding]; metal-binding site
240292008306	dimer interface [polypeptide binding]; other site
240292008307	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
240292008308	YciI-like protein; Reviewed; Region: PRK12864
240292008309	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
240292008310	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
240292008311	putative tRNA-binding site [nucleotide binding]; other site
240292008312	B3/4 domain; Region: B3_4; pfam03483
240292008313	tRNA synthetase B5 domain; Region: B5; smart00874
240292008314	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
240292008315	dimer interface [polypeptide binding]; other site
240292008316	motif 1; other site
240292008317	motif 3; other site
240292008318	motif 2; other site
240292008319	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
240292008320	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
240292008321	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
240292008322	putative active site [active]
240292008323	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
240292008324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292008325	FeS/SAM binding site; other site
240292008326	HemN C-terminal domain; Region: HemN_C; pfam06969
240292008327	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292008328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008329	Walker A/P-loop; other site
240292008330	ATP binding site [chemical binding]; other site
240292008331	Q-loop/lid; other site
240292008332	ABC transporter signature motif; other site
240292008333	Walker B; other site
240292008334	D-loop; other site
240292008335	H-loop/switch region; other site
240292008336	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292008337	active site
240292008338	metal binding site [ion binding]; metal-binding site
240292008339	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292008340	active site
240292008341	metal binding site [ion binding]; metal-binding site
240292008342	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292008343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292008344	S-adenosylmethionine binding site [chemical binding]; other site
240292008345	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292008346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292008347	motif II; other site
240292008348	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
240292008349	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
240292008350	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
240292008351	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292008352	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292008353	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
240292008354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292008355	Walker A motif; other site
240292008356	ATP binding site [chemical binding]; other site
240292008357	Walker B motif; other site
240292008358	arginine finger; other site
240292008359	Peptidase family M41; Region: Peptidase_M41; pfam01434
240292008360	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
240292008361	ABC1 family; Region: ABC1; pfam03109
240292008362	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
240292008363	active site
240292008364	ATP binding site [chemical binding]; other site
240292008365	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
240292008366	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
240292008367	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
240292008368	Walker A/P-loop; other site
240292008369	ATP binding site [chemical binding]; other site
240292008370	Q-loop/lid; other site
240292008371	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
240292008372	ABC transporter signature motif; other site
240292008373	Walker B; other site
240292008374	D-loop; other site
240292008375	H-loop/switch region; other site
240292008376	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292008377	putative active site [active]
240292008378	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292008379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008380	active site
240292008381	phosphorylation site [posttranslational modification]
240292008382	intermolecular recognition site; other site
240292008383	dimerization interface [polypeptide binding]; other site
240292008384	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292008385	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292008386	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292008387	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292008388	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008390	dimer interface [polypeptide binding]; other site
240292008391	phosphorylation site [posttranslational modification]
240292008392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008393	ATP binding site [chemical binding]; other site
240292008394	Mg2+ binding site [ion binding]; other site
240292008395	G-X-G motif; other site
240292008396	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008398	active site
240292008399	phosphorylation site [posttranslational modification]
240292008400	intermolecular recognition site; other site
240292008401	dimerization interface [polypeptide binding]; other site
240292008402	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240292008403	cyclase homology domain; Region: CHD; cd07302
240292008404	nucleotidyl binding site; other site
240292008405	metal binding site [ion binding]; metal-binding site
240292008406	dimer interface [polypeptide binding]; other site
240292008407	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292008408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292008409	Coenzyme A binding pocket [chemical binding]; other site
240292008410	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
240292008411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292008412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292008413	homodimer interface [polypeptide binding]; other site
240292008414	catalytic residue [active]
240292008415	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
240292008416	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292008417	glutathione reductase; Validated; Region: PRK06116
240292008418	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292008419	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292008420	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240292008421	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
240292008422	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
240292008423	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
240292008424	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
240292008425	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
240292008426	Predicted transcriptional regulators [Transcription]; Region: COG1695
240292008427	Transcriptional regulator PadR-like family; Region: PadR; cl17335
240292008428	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
240292008429	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292008430	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292008431	DevC protein; Region: devC; TIGR01185
240292008432	FtsX-like permease family; Region: FtsX; pfam02687
240292008433	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292008434	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292008435	Walker A/P-loop; other site
240292008436	ATP binding site [chemical binding]; other site
240292008437	Q-loop/lid; other site
240292008438	ABC transporter signature motif; other site
240292008439	Walker B; other site
240292008440	D-loop; other site
240292008441	H-loop/switch region; other site
240292008442	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
240292008443	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292008444	putative active site [active]
240292008445	putative metal binding site [ion binding]; other site
240292008446	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292008447	recombination protein RecR; Reviewed; Region: recR; PRK00076
240292008448	RecR protein; Region: RecR; pfam02132
240292008449	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
240292008450	putative active site [active]
240292008451	putative metal-binding site [ion binding]; other site
240292008452	tetramer interface [polypeptide binding]; other site
240292008453	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292008454	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292008455	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292008456	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292008457	DNA binding residues [nucleotide binding]
240292008458	dimerization interface [polypeptide binding]; other site
240292008459	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
240292008460	Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747
240292008461	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
240292008462	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
240292008463	NAD(P) binding site [chemical binding]; other site
240292008464	catalytic residues [active]
240292008465	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
240292008466	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
240292008467	hinge; other site
240292008468	active site
240292008469	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
240292008470	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
240292008471	dimer interface [polypeptide binding]; other site
240292008472	motif 1; other site
240292008473	active site
240292008474	motif 2; other site
240292008475	motif 3; other site
240292008476	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
240292008477	anticodon binding site; other site
240292008478	SnoaL-like domain; Region: SnoaL_2; pfam12680
240292008479	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
240292008480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292008481	dimer interface [polypeptide binding]; other site
240292008482	conserved gate region; other site
240292008483	ABC-ATPase subunit interface; other site
240292008484	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240292008485	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240292008486	nucleotide binding site [chemical binding]; other site
240292008487	CTP synthetase; Validated; Region: pyrG; PRK05380
240292008488	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
240292008489	Catalytic site [active]
240292008490	active site
240292008491	UTP binding site [chemical binding]; other site
240292008492	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
240292008493	active site
240292008494	putative oxyanion hole; other site
240292008495	catalytic triad [active]
240292008496	Bacterial SH3 domain; Region: SH3_3; pfam08239
240292008497	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292008498	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240292008499	active site
240292008500	metal binding site [ion binding]; metal-binding site
240292008501	XisI protein; Region: XisI; pfam08869
240292008502	XisH protein; Region: XisH; pfam08814
240292008503	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
240292008504	Amidinotransferase; Region: Amidinotransf; cl12043
240292008505	Uncharacterized conserved protein [Function unknown]; Region: COG1915
240292008506	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
240292008507	homodimer interface [polypeptide binding]; other site
240292008508	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
240292008509	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
240292008510	nudix motif; other site
240292008511	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292008512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292008513	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292008514	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
240292008515	Fatty acid desaturase; Region: FA_desaturase; pfam00487
240292008516	Di-iron ligands [ion binding]; other site
240292008517	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
240292008518	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
240292008519	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
240292008520	DNA binding site [nucleotide binding]
240292008521	active site
240292008522	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
240292008523	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
240292008524	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
240292008525	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
240292008526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
240292008527	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240292008528	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292008529	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
240292008530	putative dimerization interface [polypeptide binding]; other site
240292008531	sucrose synthase; Region: sucr_synth; TIGR02470
240292008532	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
240292008533	putative ADP-binding pocket [chemical binding]; other site
240292008534	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292008535	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292008536	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
240292008537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292008538	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
240292008539	NAD(P) binding site [chemical binding]; other site
240292008540	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
240292008541	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
240292008542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292008543	active site
240292008544	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
240292008545	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
240292008546	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292008547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
240292008548	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
240292008549	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
240292008550	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
240292008551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292008552	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292008553	Walker A motif; other site
240292008554	ATP binding site [chemical binding]; other site
240292008555	Walker B motif; other site
240292008556	arginine finger; other site
240292008557	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
240292008558	Protein of unknown function DUF58; Region: DUF58; pfam01882
240292008559	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
240292008560	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240292008561	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240292008562	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
240292008563	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
240292008564	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
240292008565	gamma subunit interface [polypeptide binding]; other site
240292008566	epsilon subunit interface [polypeptide binding]; other site
240292008567	LBP interface [polypeptide binding]; other site
240292008568	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
240292008569	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
240292008570	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
240292008571	alpha subunit interaction interface [polypeptide binding]; other site
240292008572	Walker A motif; other site
240292008573	ATP binding site [chemical binding]; other site
240292008574	Walker B motif; other site
240292008575	inhibitor binding site; inhibition site
240292008576	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
240292008577	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
240292008578	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
240292008579	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
240292008580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292008581	dimer interface [polypeptide binding]; other site
240292008582	conserved gate region; other site
240292008583	putative PBP binding loops; other site
240292008584	ABC-ATPase subunit interface; other site
240292008585	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
240292008586	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292008587	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
240292008588	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
240292008589	Walker A/P-loop; other site
240292008590	ATP binding site [chemical binding]; other site
240292008591	Q-loop/lid; other site
240292008592	ABC transporter signature motif; other site
240292008593	Walker B; other site
240292008594	D-loop; other site
240292008595	H-loop/switch region; other site
240292008596	TOBE domain; Region: TOBE_2; pfam08402
240292008597	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
240292008598	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
240292008599	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240292008600	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
240292008601	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
240292008602	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
240292008603	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
240292008604	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292008605	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292008606	putative active site [active]
240292008607	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
240292008608	prolyl-tRNA synthetase; Provisional; Region: PRK09194
240292008609	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
240292008610	dimer interface [polypeptide binding]; other site
240292008611	motif 1; other site
240292008612	active site
240292008613	motif 2; other site
240292008614	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
240292008615	putative deacylase active site [active]
240292008616	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
240292008617	active site
240292008618	motif 3; other site
240292008619	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
240292008620	anticodon binding site; other site
240292008621	Spore germination protein [General function prediction only]; Region: COG5401
240292008622	Sporulation and spore germination; Region: Germane; pfam10646
240292008623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292008624	putative DNA binding site [nucleotide binding]; other site
240292008625	putative Zn2+ binding site [ion binding]; other site
240292008626	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
240292008627	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
240292008628	carboxyltransferase (CT) interaction site; other site
240292008629	biotinylation site [posttranslational modification]; other site
240292008630	elongation factor P; Validated; Region: PRK00529
240292008631	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
240292008632	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
240292008633	RNA binding site [nucleotide binding]; other site
240292008634	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
240292008635	RNA binding site [nucleotide binding]; other site
240292008636	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
240292008637	active site
240292008638	thiamine monophosphate kinase; Provisional; Region: PRK05731
240292008639	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
240292008640	ATP binding site [chemical binding]; other site
240292008641	dimerization interface [polypeptide binding]; other site
240292008642	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
240292008643	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
240292008644	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
240292008645	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
240292008646	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
240292008647	active site
240292008648	(T/H)XGH motif; other site
240292008649	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
240292008650	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240292008651	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292008652	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292008653	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
240292008654	FAD binding domain; Region: FAD_binding_4; pfam01565
240292008655	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
240292008656	hypothetical protein; Validated; Region: PRK00153
240292008657	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
240292008658	Low molecular weight phosphatase family; Region: LMWPc; cd00115
240292008659	active site
240292008660	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292008661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008662	active site
240292008663	phosphorylation site [posttranslational modification]
240292008664	intermolecular recognition site; other site
240292008665	dimerization interface [polypeptide binding]; other site
240292008666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292008667	DNA binding residues [nucleotide binding]
240292008668	dimerization interface [polypeptide binding]; other site
240292008669	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
240292008670	SmpB-tmRNA interface; other site
240292008671	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240292008672	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
240292008673	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292008674	GAF domain; Region: GAF; pfam01590
240292008675	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008677	dimer interface [polypeptide binding]; other site
240292008678	phosphorylation site [posttranslational modification]
240292008679	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
240292008680	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
240292008681	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
240292008682	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
240292008683	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
240292008684	P-loop; other site
240292008685	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
240292008686	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292008687	putative active site [active]
240292008688	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
240292008689	Clp amino terminal domain; Region: Clp_N; pfam02861
240292008690	Clp amino terminal domain; Region: Clp_N; pfam02861
240292008691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292008692	Walker A motif; other site
240292008693	ATP binding site [chemical binding]; other site
240292008694	Walker B motif; other site
240292008695	arginine finger; other site
240292008696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292008697	Walker A motif; other site
240292008698	ATP binding site [chemical binding]; other site
240292008699	Walker B motif; other site
240292008700	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240292008701	Tic20-like protein; Region: Tic20; pfam09685
240292008702	DDE superfamily endonuclease; Region: DDE_5; cl17874
240292008703	Homeodomain-like domain; Region: HTH_23; pfam13384
240292008704	Winged helix-turn helix; Region: HTH_29; pfam13551
240292008705	Phosphotransferase enzyme family; Region: APH; pfam01636
240292008706	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
240292008707	active site
240292008708	ATP binding site [chemical binding]; other site
240292008709	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292008710	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292008711	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292008712	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
240292008713	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292008714	Uncharacterized conserved protein [Function unknown]; Region: COG0398
240292008715	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
240292008716	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
240292008717	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
240292008718	Ligand binding site; other site
240292008719	Putative Catalytic site; other site
240292008720	DXD motif; other site
240292008721	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292008722	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240292008723	NAD(P) binding site [chemical binding]; other site
240292008724	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
240292008725	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
240292008726	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292008727	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008728	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292008729	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008730	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292008731	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008732	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008733	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292008734	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008735	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008736	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008737	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292008738	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292008739	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292008740	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
240292008741	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292008742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292008743	homodimer interface [polypeptide binding]; other site
240292008744	catalytic residue [active]
240292008745	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
240292008746	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
240292008747	Probable Catalytic site; other site
240292008748	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
240292008749	Transglycosylase; Region: Transgly; pfam00912
240292008750	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
240292008751	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
240292008752	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
240292008753	MG2 domain; Region: A2M_N; pfam01835
240292008754	Alpha-2-macroglobulin family; Region: A2M; pfam00207
240292008755	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
240292008756	surface patch; other site
240292008757	specificity defining residues; other site
240292008758	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292008759	active site
240292008760	Domain of unknown function DUF21; Region: DUF21; pfam01595
240292008761	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
240292008762	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
240292008763	Transporter associated domain; Region: CorC_HlyC; smart01091
240292008764	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
240292008765	Ligand Binding Site [chemical binding]; other site
240292008766	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240292008767	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240292008768	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
240292008769	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
240292008770	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
240292008771	Mg binding site [ion binding]; other site
240292008772	nucleotide binding site [chemical binding]; other site
240292008773	putative protofilament interface [polypeptide binding]; other site
240292008774	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
240292008775	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
240292008776	active site
240292008777	substrate binding site [chemical binding]; other site
240292008778	metal binding site [ion binding]; metal-binding site
240292008779	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
240292008780	active site
240292008781	dimerization interface [polypeptide binding]; other site
240292008782	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292008783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
240292008784	Homeodomain-like domain; Region: HTH_23; pfam13384
240292008785	Winged helix-turn helix; Region: HTH_29; pfam13551
240292008786	DDE superfamily endonuclease; Region: DDE_4; pfam13359
240292008787	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
240292008788	DHH family; Region: DHH; pfam01368
240292008789	DHHA1 domain; Region: DHHA1; pfam02272
240292008790	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
240292008791	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292008792	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292008793	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292008794	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292008795	Predicted membrane protein [Function unknown]; Region: COG2119
240292008796	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
240292008797	Predicted membrane protein [Function unknown]; Region: COG2119
240292008798	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
240292008799	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
240292008800	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
240292008801	dimer interface [polypeptide binding]; other site
240292008802	putative functional site; other site
240292008803	putative MPT binding site; other site
240292008804	Caspase domain; Region: Peptidase_C14; pfam00656
240292008805	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
240292008806	ATP-sulfurylase; Region: ATPS; cd00517
240292008807	active site
240292008808	HXXH motif; other site
240292008809	flexible loop; other site
240292008810	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292008811	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292008812	active site
240292008813	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
240292008814	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292008815	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292008816	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292008817	active site
240292008818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
240292008819	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
240292008820	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
240292008821	inhibitor-cofactor binding pocket; inhibition site
240292008822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292008823	catalytic residue [active]
240292008824	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292008825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292008826	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
240292008827	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
240292008828	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
240292008829	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292008830	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
240292008831	putative active site [active]
240292008832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292008833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008834	Walker A/P-loop; other site
240292008835	ATP binding site [chemical binding]; other site
240292008836	Q-loop/lid; other site
240292008837	ABC transporter signature motif; other site
240292008838	Walker B; other site
240292008839	D-loop; other site
240292008840	H-loop/switch region; other site
240292008841	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
240292008842	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292008843	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292008844	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292008845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008846	active site
240292008847	phosphorylation site [posttranslational modification]
240292008848	intermolecular recognition site; other site
240292008849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
240292008850	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292008851	CHASE2 domain; Region: CHASE2; pfam05226
240292008852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292008853	ribonuclease Z; Region: RNase_Z; TIGR02651
240292008854	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
240292008855	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
240292008856	PemK-like protein; Region: PemK; pfam02452
240292008857	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
240292008858	catalytic triad [active]
240292008859	conserved cis-peptide bond; other site
240292008860	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292008861	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240292008862	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292008863	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
240292008864	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292008865	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240292008866	protein binding site [polypeptide binding]; other site
240292008867	Protein of unknown function (DUF760); Region: DUF760; pfam05542
240292008868	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
240292008869	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
240292008870	substrate binding site; other site
240292008871	dimer interface; other site
240292008872	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
240292008873	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
240292008874	putative active site [active]
240292008875	Uncharacterized conserved protein [Function unknown]; Region: COG5474
240292008876	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292008877	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292008878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008879	active site
240292008880	phosphorylation site [posttranslational modification]
240292008881	intermolecular recognition site; other site
240292008882	dimerization interface [polypeptide binding]; other site
240292008883	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292008884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292008885	putative active site [active]
240292008886	heme pocket [chemical binding]; other site
240292008887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292008888	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292008889	putative active site [active]
240292008890	heme pocket [chemical binding]; other site
240292008891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292008892	putative active site [active]
240292008893	heme pocket [chemical binding]; other site
240292008894	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008896	dimer interface [polypeptide binding]; other site
240292008897	phosphorylation site [posttranslational modification]
240292008898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008899	ATP binding site [chemical binding]; other site
240292008900	Mg2+ binding site [ion binding]; other site
240292008901	G-X-G motif; other site
240292008902	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008904	active site
240292008905	phosphorylation site [posttranslational modification]
240292008906	intermolecular recognition site; other site
240292008907	dimerization interface [polypeptide binding]; other site
240292008908	Response regulator receiver domain; Region: Response_reg; pfam00072
240292008909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008910	active site
240292008911	phosphorylation site [posttranslational modification]
240292008912	intermolecular recognition site; other site
240292008913	dimerization interface [polypeptide binding]; other site
240292008914	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292008915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008916	active site
240292008917	phosphorylation site [posttranslational modification]
240292008918	intermolecular recognition site; other site
240292008919	dimerization interface [polypeptide binding]; other site
240292008920	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292008921	DNA binding site [nucleotide binding]
240292008922	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292008923	putative binding surface; other site
240292008924	active site
240292008925	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292008926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008927	active site
240292008928	phosphorylation site [posttranslational modification]
240292008929	intermolecular recognition site; other site
240292008930	dimerization interface [polypeptide binding]; other site
240292008931	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292008932	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292008933	metal binding site [ion binding]; metal-binding site
240292008934	active site
240292008935	I-site; other site
240292008936	Protein of unknown function (DUF760); Region: DUF760; pfam05542
240292008937	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
240292008938	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
240292008939	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292008940	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
240292008941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292008942	S-adenosylmethionine binding site [chemical binding]; other site
240292008943	short chain dehydrogenase; Provisional; Region: PRK06701
240292008944	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
240292008945	NAD binding site [chemical binding]; other site
240292008946	metal binding site [ion binding]; metal-binding site
240292008947	active site
240292008948	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
240292008949	MgtE intracellular N domain; Region: MgtE_N; smart00924
240292008950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
240292008951	Divalent cation transporter; Region: MgtE; pfam01769
240292008952	mercuric reductase; Validated; Region: PRK06370
240292008953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292008954	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240292008955	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
240292008956	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292008957	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
240292008958	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
240292008959	putative ADP-binding pocket [chemical binding]; other site
240292008960	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292008961	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
240292008962	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292008963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292008964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292008965	Walker A/P-loop; other site
240292008966	ATP binding site [chemical binding]; other site
240292008967	Q-loop/lid; other site
240292008968	ABC transporter signature motif; other site
240292008969	Walker B; other site
240292008970	D-loop; other site
240292008971	H-loop/switch region; other site
240292008972	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
240292008973	active site
240292008974	substrate binding site [chemical binding]; other site
240292008975	ATP binding site [chemical binding]; other site
240292008976	Phosphotransferase enzyme family; Region: APH; pfam01636
240292008977	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292008978	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
240292008979	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
240292008980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292008981	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292008982	dimerization interface [polypeptide binding]; other site
240292008983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292008984	dimer interface [polypeptide binding]; other site
240292008985	phosphorylation site [posttranslational modification]
240292008986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292008987	ATP binding site [chemical binding]; other site
240292008988	Mg2+ binding site [ion binding]; other site
240292008989	G-X-G motif; other site
240292008990	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292008991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292008992	active site
240292008993	phosphorylation site [posttranslational modification]
240292008994	intermolecular recognition site; other site
240292008995	dimerization interface [polypeptide binding]; other site
240292008996	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292008997	DNA binding site [nucleotide binding]
240292008998	Predicted flavoprotein [General function prediction only]; Region: COG0431
240292008999	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240292009000	cell division protein; Validated; Region: ftsH; CHL00176
240292009001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292009002	Walker A motif; other site
240292009003	ATP binding site [chemical binding]; other site
240292009004	Walker B motif; other site
240292009005	arginine finger; other site
240292009006	Peptidase family M41; Region: Peptidase_M41; pfam01434
240292009007	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
240292009008	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
240292009009	glutaminase; Provisional; Region: PRK00971
240292009010	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
240292009011	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
240292009012	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
240292009013	active site
240292009014	intersubunit interface [polypeptide binding]; other site
240292009015	catalytic residue [active]
240292009016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
240292009017	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
240292009018	Integrase core domain; Region: rve; pfam00665
240292009019	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292009020	AAA domain; Region: AAA_22; pfam13401
240292009021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
240292009022	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
240292009023	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292009024	metal binding site [ion binding]; metal-binding site
240292009025	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292009026	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292009027	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
240292009028	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
240292009029	Malic enzyme, N-terminal domain; Region: malic; pfam00390
240292009030	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
240292009031	putative NAD(P) binding site [chemical binding]; other site
240292009032	Tudor domain; Region: TUDOR; smart00333
240292009033	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
240292009034	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
240292009035	protein I interface; other site
240292009036	D2 interface; other site
240292009037	protein T interface; other site
240292009038	chlorophyll binding site; other site
240292009039	beta carotene binding site; other site
240292009040	pheophytin binding site; other site
240292009041	manganese-stabilizing polypeptide interface; other site
240292009042	CP43 interface; other site
240292009043	protein L interface; other site
240292009044	oxygen evolving complex binding site; other site
240292009045	bromide binding site; other site
240292009046	quinone binding site; other site
240292009047	Fe binding site [ion binding]; other site
240292009048	core light harvesting interface; other site
240292009049	cytochrome b559 alpha subunit interface; other site
240292009050	cytochrome c-550 interface; other site
240292009051	protein J interface; other site
240292009052	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
240292009053	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
240292009054	homotetramer interface [polypeptide binding]; other site
240292009055	FMN binding site [chemical binding]; other site
240292009056	homodimer contacts [polypeptide binding]; other site
240292009057	putative active site [active]
240292009058	putative substrate binding site [chemical binding]; other site
240292009059	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
240292009060	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
240292009061	oligomer interface [polypeptide binding]; other site
240292009062	tandem repeat interface [polypeptide binding]; other site
240292009063	active site residues [active]
240292009064	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
240292009065	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
240292009066	tandem repeat interface [polypeptide binding]; other site
240292009067	oligomer interface [polypeptide binding]; other site
240292009068	active site residues [active]
240292009069	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
240292009070	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
240292009071	CHASE4 domain; Region: CHASE4; cl01308
240292009072	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
240292009073	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292009075	dimer interface [polypeptide binding]; other site
240292009076	phosphorylation site [posttranslational modification]
240292009077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009078	ATP binding site [chemical binding]; other site
240292009079	Mg2+ binding site [ion binding]; other site
240292009080	G-X-G motif; other site
240292009081	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
240292009082	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292009083	Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656
240292009084	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
240292009085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292009086	dimer interface [polypeptide binding]; other site
240292009087	conserved gate region; other site
240292009088	ABC-ATPase subunit interface; other site
240292009089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292009090	active site
240292009091	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
240292009092	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
240292009093	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292009094	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292009095	phosphopeptide binding site; other site
240292009096	Transglycosylase; Region: Transgly; pfam00912
240292009097	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
240292009098	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240292009099	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
240292009100	lipoprotein signal peptidase; Provisional; Region: PRK14787
240292009101	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
240292009102	PBP superfamily domain; Region: PBP_like_2; cl17296
240292009103	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
240292009104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292009105	dimer interface [polypeptide binding]; other site
240292009106	conserved gate region; other site
240292009107	putative PBP binding loops; other site
240292009108	ABC-ATPase subunit interface; other site
240292009109	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
240292009110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292009111	dimer interface [polypeptide binding]; other site
240292009112	conserved gate region; other site
240292009113	putative PBP binding loops; other site
240292009114	ABC-ATPase subunit interface; other site
240292009115	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
240292009116	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240292009117	Walker A/P-loop; other site
240292009118	ATP binding site [chemical binding]; other site
240292009119	Q-loop/lid; other site
240292009120	ABC transporter signature motif; other site
240292009121	Walker B; other site
240292009122	D-loop; other site
240292009123	H-loop/switch region; other site
240292009124	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
240292009125	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
240292009126	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
240292009127	Glucose inhibited division protein A; Region: GIDA; pfam01134
240292009128	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292009129	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
240292009130	C-terminal domain interface [polypeptide binding]; other site
240292009131	GSH binding site (G-site) [chemical binding]; other site
240292009132	dimer interface [polypeptide binding]; other site
240292009133	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
240292009134	N-terminal domain interface [polypeptide binding]; other site
240292009135	dimer interface [polypeptide binding]; other site
240292009136	substrate binding pocket (H-site) [chemical binding]; other site
240292009137	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
240292009138	active site
240292009139	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
240292009140	dimer interface [polypeptide binding]; other site
240292009141	hexamer interface [polypeptide binding]; other site
240292009142	active site 2 [active]
240292009143	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292009144	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292009145	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292009146	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292009147	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292009148	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
240292009149	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
240292009150	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
240292009151	dimer interface [polypeptide binding]; other site
240292009152	active site
240292009153	metal binding site [ion binding]; metal-binding site
240292009154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292009155	PAS domain; Region: PAS_9; pfam13426
240292009156	putative active site [active]
240292009157	heme pocket [chemical binding]; other site
240292009158	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292009159	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292009160	putative switch regulator; other site
240292009161	non-specific DNA interactions [nucleotide binding]; other site
240292009162	DNA binding site [nucleotide binding]
240292009163	sequence specific DNA binding site [nucleotide binding]; other site
240292009164	putative cAMP binding site [chemical binding]; other site
240292009165	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
240292009166	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
240292009167	intersubunit interface [polypeptide binding]; other site
240292009168	active site
240292009169	zinc binding site [ion binding]; other site
240292009170	Na+ binding site [ion binding]; other site
240292009171	Protein of unknown function (DUF433); Region: DUF433; pfam04255
240292009172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
240292009173	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
240292009174	putative active site [active]
240292009175	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
240292009176	Uncharacterized conserved protein [Function unknown]; Region: COG2442
240292009177	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292009178	structural tetrad; other site
240292009179	PQQ-like domain; Region: PQQ_2; pfam13360
240292009180	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
240292009181	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
240292009182	[2Fe-2S] cluster binding site [ion binding]; other site
240292009183	Rubredoxin [Energy production and conversion]; Region: COG1773
240292009184	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
240292009185	iron binding site [ion binding]; other site
240292009186	flavoprotein, HI0933 family; Region: TIGR00275
240292009187	tellurite resistance protein terB; Region: terB; cd07176
240292009188	putative metal binding site [ion binding]; other site
240292009189	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
240292009190	active site
240292009191	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
240292009192	active site
240292009193	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
240292009194	oligomeric interface; other site
240292009195	putative active site [active]
240292009196	homodimer interface [polypeptide binding]; other site
240292009197	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
240292009198	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292009199	HSP70 interaction site [polypeptide binding]; other site
240292009200	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240292009201	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240292009202	dimer interface [polypeptide binding]; other site
240292009203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292009204	catalytic residue [active]
240292009205	Predicted transcriptional regulator [Transcription]; Region: COG1959
240292009206	Transcriptional regulator; Region: Rrf2; pfam02082
240292009207	S-layer homology domain; Region: SLH; pfam00395
240292009208	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292009209	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
240292009210	aromatic arch; other site
240292009211	DCoH dimer interaction site [polypeptide binding]; other site
240292009212	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
240292009213	DCoH tetramer interaction site [polypeptide binding]; other site
240292009214	substrate binding site [chemical binding]; other site
240292009215	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
240292009216	D1 interface; other site
240292009217	chlorophyll binding site; other site
240292009218	pheophytin binding site; other site
240292009219	beta carotene binding site; other site
240292009220	cytochrome b559 beta interface; other site
240292009221	quinone binding site; other site
240292009222	cytochrome b559 alpha interface; other site
240292009223	protein J interface; other site
240292009224	protein H interface; other site
240292009225	protein X interface; other site
240292009226	core light harvesting protein interface; other site
240292009227	protein L interface; other site
240292009228	CP43 interface; other site
240292009229	protein T interface; other site
240292009230	Fe binding site [ion binding]; other site
240292009231	protein M interface; other site
240292009232	Mn-stabilizing polypeptide interface; other site
240292009233	bromide binding site; other site
240292009234	cytochrome c-550 interface; other site
240292009235	hypothetical protein; Provisional; Region: PRK13683
240292009236	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292009237	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292009238	Walker A/P-loop; other site
240292009239	ATP binding site [chemical binding]; other site
240292009240	Q-loop/lid; other site
240292009241	ABC transporter signature motif; other site
240292009242	Walker B; other site
240292009243	D-loop; other site
240292009244	H-loop/switch region; other site
240292009245	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
240292009246	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
240292009247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009248	Mg2+ binding site [ion binding]; other site
240292009249	G-X-G motif; other site
240292009250	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
240292009251	anchoring element; other site
240292009252	dimer interface [polypeptide binding]; other site
240292009253	ATP binding site [chemical binding]; other site
240292009254	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
240292009255	active site
240292009256	putative metal-binding site [ion binding]; other site
240292009257	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
240292009258	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
240292009259	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
240292009260	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292009261	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292009262	active site
240292009263	ATP binding site [chemical binding]; other site
240292009264	substrate binding site [chemical binding]; other site
240292009265	activation loop (A-loop); other site
240292009266	KWG Leptospira; Region: KWG; pfam07656
240292009267	KWG Leptospira; Region: KWG; pfam07656
240292009268	KWG Leptospira; Region: KWG; pfam07656
240292009269	FAD binding domain; Region: FAD_binding_4; pfam01565
240292009270	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
240292009271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292009272	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292009273	PAS fold; Region: PAS_4; pfam08448
240292009274	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292009275	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292009276	GAF domain; Region: GAF; pfam01590
240292009277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292009279	dimer interface [polypeptide binding]; other site
240292009280	phosphorylation site [posttranslational modification]
240292009281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009282	ATP binding site [chemical binding]; other site
240292009283	G-X-G motif; other site
240292009284	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
240292009285	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
240292009286	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
240292009287	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
240292009288	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292009289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292009290	active site
240292009291	ATP binding site [chemical binding]; other site
240292009292	substrate binding site [chemical binding]; other site
240292009293	activation loop (A-loop); other site
240292009294	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292009295	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292009296	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
240292009297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292009298	dimer interface [polypeptide binding]; other site
240292009299	conserved gate region; other site
240292009300	putative PBP binding loops; other site
240292009301	ABC-ATPase subunit interface; other site
240292009302	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
240292009303	dinuclear metal binding motif [ion binding]; other site
240292009304	acyl-ACP reductase; Provisional; Region: PRK14982
240292009305	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
240292009306	NAD(P) binding pocket [chemical binding]; other site
240292009307	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
240292009308	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
240292009309	short chain dehydrogenase; Provisional; Region: PRK07454
240292009310	classical (c) SDRs; Region: SDR_c; cd05233
240292009311	NAD(P) binding site [chemical binding]; other site
240292009312	active site
240292009313	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
240292009314	homodecamer interface [polypeptide binding]; other site
240292009315	GTP cyclohydrolase I; Provisional; Region: PLN03044
240292009316	active site
240292009317	putative catalytic site residues [active]
240292009318	zinc binding site [ion binding]; other site
240292009319	GTP-CH-I/GFRP interaction surface; other site
240292009320	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
240292009321	active site
240292009322	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
240292009323	photosystem I reaction center subunit X-like protein; Reviewed; Region: PRK13216
240292009324	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240292009325	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292009326	CpeS-like protein; Region: CpeS; pfam09367
240292009327	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240292009328	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292009329	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
240292009330	Predicted ATPases [General function prediction only]; Region: COG1106
240292009331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292009332	Walker A/P-loop; other site
240292009333	ATP binding site [chemical binding]; other site
240292009334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292009335	ABC transporter signature motif; other site
240292009336	Walker B; other site
240292009337	D-loop; other site
240292009338	H-loop/switch region; other site
240292009339	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
240292009340	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
240292009341	putative NADP binding site [chemical binding]; other site
240292009342	putative substrate binding site [chemical binding]; other site
240292009343	active site
240292009344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292009345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292009346	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
240292009347	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
240292009348	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
240292009349	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
240292009350	putative homodimer interface [polypeptide binding]; other site
240292009351	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
240292009352	heterodimer interface [polypeptide binding]; other site
240292009353	homodimer interface [polypeptide binding]; other site
240292009354	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
240292009355	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
240292009356	23S rRNA interface [nucleotide binding]; other site
240292009357	L7/L12 interface [polypeptide binding]; other site
240292009358	putative thiostrepton binding site; other site
240292009359	L25 interface [polypeptide binding]; other site
240292009360	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
240292009361	mRNA/rRNA interface [nucleotide binding]; other site
240292009362	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
240292009363	23S rRNA interface [nucleotide binding]; other site
240292009364	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
240292009365	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
240292009366	L11 interface [polypeptide binding]; other site
240292009367	putative EF-Tu interaction site [polypeptide binding]; other site
240292009368	putative EF-G interaction site [polypeptide binding]; other site
240292009369	Homeodomain-like domain; Region: HTH_23; pfam13384
240292009370	Winged helix-turn helix; Region: HTH_29; pfam13551
240292009371	Winged helix-turn helix; Region: HTH_33; pfam13592
240292009372	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292009373	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
240292009374	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
240292009375	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
240292009376	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292009377	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
240292009378	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
240292009379	NAD(P) binding site [chemical binding]; other site
240292009380	putative active site [active]
240292009381	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
240292009382	putative catalytic site [active]
240292009383	putative phosphate binding site [ion binding]; other site
240292009384	active site
240292009385	metal binding site A [ion binding]; metal-binding site
240292009386	DNA binding site [nucleotide binding]
240292009387	putative AP binding site [nucleotide binding]; other site
240292009388	putative metal binding site B [ion binding]; other site
240292009389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292009390	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
240292009391	putative ADP-binding pocket [chemical binding]; other site
240292009392	Response regulator receiver domain; Region: Response_reg; pfam00072
240292009393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292009394	active site
240292009395	phosphorylation site [posttranslational modification]
240292009396	intermolecular recognition site; other site
240292009397	dimerization interface [polypeptide binding]; other site
240292009398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292009399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009400	dimer interface [polypeptide binding]; other site
240292009401	phosphorylation site [posttranslational modification]
240292009402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009403	ATP binding site [chemical binding]; other site
240292009404	Mg2+ binding site [ion binding]; other site
240292009405	G-X-G motif; other site
240292009406	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292009407	CHASE2 domain; Region: CHASE2; pfam05226
240292009408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009409	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292009410	dimer interface [polypeptide binding]; other site
240292009411	phosphorylation site [posttranslational modification]
240292009412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009413	ATP binding site [chemical binding]; other site
240292009414	Mg2+ binding site [ion binding]; other site
240292009415	G-X-G motif; other site
240292009416	Response regulator receiver domain; Region: Response_reg; pfam00072
240292009417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292009418	active site
240292009419	phosphorylation site [posttranslational modification]
240292009420	intermolecular recognition site; other site
240292009421	dimerization interface [polypeptide binding]; other site
240292009422	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292009423	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292009424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292009425	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
240292009426	Virulence-associated protein E; Region: VirE; pfam05272
240292009427	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
240292009428	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292009429	DNA binding site [nucleotide binding]
240292009430	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292009431	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
240292009432	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292009433	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
240292009434	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292009435	active site
240292009436	metal binding site [ion binding]; metal-binding site
240292009437	hexamer interface [polypeptide binding]; other site
240292009438	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
240292009439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292009440	TPR motif; other site
240292009441	binding surface
240292009442	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292009443	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292009444	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
240292009445	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
240292009446	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292009447	active site
240292009448	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
240292009449	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292009450	active site
240292009451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
240292009452	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292009453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292009454	NAD(P) binding site [chemical binding]; other site
240292009455	active site
240292009456	DevC protein; Region: devC; TIGR01185
240292009457	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292009458	FtsX-like permease family; Region: FtsX; pfam02687
240292009459	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292009460	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292009461	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292009462	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
240292009463	ParB-like nuclease domain; Region: ParB; smart00470
240292009464	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
240292009465	DNA methylase; Region: N6_N4_Mtase; cl17433
240292009466	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292009467	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
240292009468	active site
240292009469	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292009470	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292009471	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
240292009472	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292009473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292009474	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
240292009475	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
240292009476	putative NADP binding site [chemical binding]; other site
240292009477	active site
240292009478	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
240292009479	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
240292009480	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292009481	active site
240292009482	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
240292009483	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292009484	active site
240292009485	Acyl transferase domain; Region: Acyl_transf_1; cl08282
240292009486	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
240292009487	FMN binding site [chemical binding]; other site
240292009488	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
240292009489	substrate binding site [chemical binding]; other site
240292009490	putative catalytic residue [active]
240292009491	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292009492	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
240292009493	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
240292009494	putative NAD(P) binding site [chemical binding]; other site
240292009495	active site
240292009496	putative substrate binding site [chemical binding]; other site
240292009497	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
240292009498	putative NAD(P) binding site [chemical binding]; other site
240292009499	active site
240292009500	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
240292009501	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
240292009502	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
240292009503	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
240292009504	putative ligand binding site [chemical binding]; other site
240292009505	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
240292009506	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
240292009507	Walker A/P-loop; other site
240292009508	ATP binding site [chemical binding]; other site
240292009509	Q-loop/lid; other site
240292009510	ABC transporter signature motif; other site
240292009511	Walker B; other site
240292009512	D-loop; other site
240292009513	H-loop/switch region; other site
240292009514	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
240292009515	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
240292009516	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
240292009517	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
240292009518	TM-ABC transporter signature motif; other site
240292009519	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
240292009520	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
240292009521	TM-ABC transporter signature motif; other site
240292009522	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
240292009523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292009524	S-adenosylmethionine binding site [chemical binding]; other site
240292009525	Uncharacterized conserved protein [Function unknown]; Region: COG2128
240292009526	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
240292009527	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240292009528	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292009529	putative active site [active]
240292009530	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
240292009531	core domain interface [polypeptide binding]; other site
240292009532	delta subunit interface [polypeptide binding]; other site
240292009533	epsilon subunit interface [polypeptide binding]; other site
240292009534	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
240292009535	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
240292009536	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
240292009537	beta subunit interaction interface [polypeptide binding]; other site
240292009538	Walker A motif; other site
240292009539	ATP binding site [chemical binding]; other site
240292009540	Walker B motif; other site
240292009541	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
240292009542	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
240292009543	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
240292009544	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
240292009545	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
240292009546	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
240292009547	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
240292009548	ATP synthase CF0 C subunit; Region: atpH; CHL00061
240292009549	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
240292009550	ATP synthase CF0 A subunit; Region: atpI; CHL00046
240292009551	ATP synthase I chain; Region: ATP_synt_I; pfam03899
240292009552	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292009553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292009554	S-adenosylmethionine binding site [chemical binding]; other site
240292009555	phycobillisome linker protein; Region: apcE; CHL00091
240292009556	Phycobilisome protein; Region: Phycobilisome; cl08227
240292009557	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292009558	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292009559	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292009560	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292009561	Phycobilisome protein; Region: Phycobilisome; cl08227
240292009562	Phycobilisome protein; Region: Phycobilisome; cl08227
240292009563	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
240292009564	Uncharacterized conserved protein [Function unknown]; Region: COG2912
240292009565	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
240292009566	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
240292009567	hydrophobic ligand binding site; other site
240292009568	AAA ATPase domain; Region: AAA_16; pfam13191
240292009569	NACHT domain; Region: NACHT; pfam05729
240292009570	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292009571	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292009572	structural tetrad; other site
240292009573	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292009574	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292009575	structural tetrad; other site
240292009576	WD40 repeats; Region: WD40; smart00320
240292009577	B12 binding domain; Region: B12-binding; pfam02310
240292009578	B12 binding site [chemical binding]; other site
240292009579	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
240292009580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292009581	FeS/SAM binding site; other site
240292009582	glycogen synthase; Provisional; Region: glgA; PRK00654
240292009583	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
240292009584	ADP-binding pocket [chemical binding]; other site
240292009585	homodimer interface [polypeptide binding]; other site
240292009586	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
240292009587	chorismate binding enzyme; Region: Chorismate_bind; cl10555
240292009588	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
240292009589	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292009590	Transposase domain (DUF772); Region: DUF772; pfam05598
240292009591	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292009592	O-succinylbenzoate synthase; Provisional; Region: PRK02714
240292009593	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
240292009594	active site
240292009595	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
240292009596	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
240292009597	acyl-activating enzyme (AAE) consensus motif; other site
240292009598	putative AMP binding site [chemical binding]; other site
240292009599	putative active site [active]
240292009600	putative CoA binding site [chemical binding]; other site
240292009601	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
240292009602	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240292009603	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292009604	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292009605	tellurite resistance protein terB; Region: terB; cd07176
240292009606	putative metal binding site [ion binding]; other site
240292009607	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
240292009608	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
240292009609	NAD binding site [chemical binding]; other site
240292009610	substrate binding site [chemical binding]; other site
240292009611	homodimer interface [polypeptide binding]; other site
240292009612	active site
240292009613	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292009614	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292009615	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292009616	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292009617	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
240292009618	Ycf35; Provisional; Region: ycf35; CHL00193
240292009619	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
240292009620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298
240292009621	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
240292009622	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
240292009623	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
240292009624	MutS domain III; Region: MutS_III; pfam05192
240292009625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292009626	Walker A/P-loop; other site
240292009627	ATP binding site [chemical binding]; other site
240292009628	Q-loop/lid; other site
240292009629	ABC transporter signature motif; other site
240292009630	Walker B; other site
240292009631	D-loop; other site
240292009632	H-loop/switch region; other site
240292009633	Smr domain; Region: Smr; pfam01713
240292009634	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
240292009635	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
240292009636	active site
240292009637	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292009638	catalytic residues [active]
240292009639	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
240292009640	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
240292009641	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
240292009642	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240292009643	Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DodA; COG3805
240292009644	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
240292009645	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
240292009646	putative ligand binding site [chemical binding]; other site
240292009647	putative NAD binding site [chemical binding]; other site
240292009648	catalytic site [active]
240292009649	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292009650	Chain length determinant protein; Region: Wzz; cl15801
240292009651	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
240292009652	AAA domain; Region: AAA_31; pfam13614
240292009653	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292009654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
240292009655	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
240292009656	Protein of unknown function (DUF751); Region: DUF751; pfam05421
240292009657	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
240292009658	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
240292009659	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
240292009660	trimer interface [polypeptide binding]; other site
240292009661	active site
240292009662	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
240292009663	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
240292009664	adenylate kinase; Reviewed; Region: adk; PRK00279
240292009665	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
240292009666	AMP-binding site [chemical binding]; other site
240292009667	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
240292009668	ribonuclease PH; Reviewed; Region: rph; PRK00173
240292009669	Ribonuclease PH; Region: RNase_PH_bact; cd11362
240292009670	hexamer interface [polypeptide binding]; other site
240292009671	active site
240292009672	carotene isomerase; Region: carot_isom; TIGR02730
240292009673	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292009674	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
240292009675	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
240292009676	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
240292009677	Walker A/P-loop; other site
240292009678	ATP binding site [chemical binding]; other site
240292009679	Q-loop/lid; other site
240292009680	ABC transporter signature motif; other site
240292009681	Walker B; other site
240292009682	D-loop; other site
240292009683	H-loop/switch region; other site
240292009684	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
240292009685	mce related protein; Region: MCE; pfam02470
240292009686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292009687	PAS fold; Region: PAS_3; pfam08447
240292009688	putative active site [active]
240292009689	heme pocket [chemical binding]; other site
240292009690	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292009692	dimer interface [polypeptide binding]; other site
240292009693	phosphorylation site [posttranslational modification]
240292009694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009695	ATP binding site [chemical binding]; other site
240292009696	Mg2+ binding site [ion binding]; other site
240292009697	G-X-G motif; other site
240292009698	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292009699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292009700	active site
240292009701	phosphorylation site [posttranslational modification]
240292009702	intermolecular recognition site; other site
240292009703	dimerization interface [polypeptide binding]; other site
240292009704	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
240292009705	DHH family; Region: DHH; pfam01368
240292009706	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
240292009707	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
240292009708	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292009709	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292009710	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292009711	Transcriptional regulator [Transcription]; Region: LytR; COG1316
240292009712	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
240292009713	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
240292009714	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
240292009715	Substrate binding site; other site
240292009716	Cupin domain; Region: Cupin_2; cl17218
240292009717	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
240292009718	ABC1 family; Region: ABC1; cl17513
240292009719	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
240292009720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292009721	Walker A/P-loop; other site
240292009722	ATP binding site [chemical binding]; other site
240292009723	Q-loop/lid; other site
240292009724	ABC transporter signature motif; other site
240292009725	Walker B; other site
240292009726	D-loop; other site
240292009727	H-loop/switch region; other site
240292009728	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
240292009729	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
240292009730	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292009731	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292009732	active site
240292009733	substrate binding site [chemical binding]; other site
240292009734	ATP binding site [chemical binding]; other site
240292009735	activation loop (A-loop); other site
240292009736	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292009737	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292009738	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
240292009739	ArsC family; Region: ArsC; pfam03960
240292009740	catalytic residue [active]
240292009741	Predicted integral membrane protein [Function unknown]; Region: COG0392
240292009742	hypothetical protein; Provisional; Region: PRK04194
240292009743	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
240292009744	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
240292009745	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292009746	ATP binding site [chemical binding]; other site
240292009747	putative Mg++ binding site [ion binding]; other site
240292009748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292009749	nucleotide binding region [chemical binding]; other site
240292009750	ATP-binding site [chemical binding]; other site
240292009751	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
240292009752	HRDC domain; Region: HRDC; pfam00570
240292009753	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
240292009754	DNA binding residues [nucleotide binding]
240292009755	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
240292009756	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292009757	putative active site [active]
240292009758	putative metal binding site [ion binding]; other site
240292009759	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292009760	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292009761	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
240292009762	nudix motif; other site
240292009763	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
240292009764	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
240292009765	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
240292009766	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
240292009767	homodimer interface [polypeptide binding]; other site
240292009768	NADP binding site [chemical binding]; other site
240292009769	substrate binding site [chemical binding]; other site
240292009770	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
240292009771	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
240292009772	substrate binding pocket [chemical binding]; other site
240292009773	chain length determination region; other site
240292009774	substrate-Mg2+ binding site; other site
240292009775	catalytic residues [active]
240292009776	aspartate-rich region 1; other site
240292009777	active site lid residues [active]
240292009778	aspartate-rich region 2; other site
240292009779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
240292009780	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
240292009781	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
240292009782	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
240292009783	active site
240292009784	hydrophilic channel; other site
240292009785	dimerization interface [polypeptide binding]; other site
240292009786	catalytic residues [active]
240292009787	active site lid [active]
240292009788	PAS domain S-box; Region: sensory_box; TIGR00229
240292009789	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292009790	putative active site [active]
240292009791	heme pocket [chemical binding]; other site
240292009792	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292009793	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292009794	metal binding site [ion binding]; metal-binding site
240292009795	active site
240292009796	I-site; other site
240292009797	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292009798	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
240292009799	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
240292009800	catalytic core [active]
240292009801	citrate synthase; Provisional; Region: PRK14036
240292009802	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
240292009803	dimer interface [polypeptide binding]; other site
240292009804	active site
240292009805	citrylCoA binding site [chemical binding]; other site
240292009806	oxalacetate/citrate binding site [chemical binding]; other site
240292009807	coenzyme A binding site [chemical binding]; other site
240292009808	catalytic triad [active]
240292009809	NADH dehydrogenase; Region: NADHdh; cl00469
240292009810	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
240292009811	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
240292009812	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292009813	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
240292009814	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
240292009815	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
240292009816	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
240292009817	ATP-NAD kinase; Region: NAD_kinase; pfam01513
240292009818	Putative hemolysin [General function prediction only]; Region: COG3176
240292009819	Predicted membrane protein [Function unknown]; Region: COG5305
240292009820	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
240292009821	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
240292009822	Uncharacterized conserved protein [Function unknown]; Region: COG1432
240292009823	LabA_like proteins; Region: LabA; cd10911
240292009824	putative metal binding site [ion binding]; other site
240292009825	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
240292009826	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
240292009827	active site
240292009828	HIGH motif; other site
240292009829	KMSKS motif; other site
240292009830	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
240292009831	anticodon binding site; other site
240292009832	tRNA binding surface [nucleotide binding]; other site
240292009833	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292009834	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240292009835	putative acyl-acceptor binding pocket; other site
240292009836	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292009837	multifunctional aminopeptidase A; Provisional; Region: PRK00913
240292009838	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
240292009839	interface (dimer of trimers) [polypeptide binding]; other site
240292009840	Substrate-binding/catalytic site; other site
240292009841	Zn-binding sites [ion binding]; other site
240292009842	putative phosphate acyltransferase; Provisional; Region: PRK05331
240292009843	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
240292009844	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
240292009845	dimer interface [polypeptide binding]; other site
240292009846	active site
240292009847	CoA binding pocket [chemical binding]; other site
240292009848	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
240292009849	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292009850	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292009851	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240292009852	putative acyl-acceptor binding pocket; other site
240292009853	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292009854	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292009855	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
240292009856	Uncharacterized conserved protein [Function unknown]; Region: COG1434
240292009857	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240292009858	putative active site [active]
240292009859	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
240292009860	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292009861	HSP70 interaction site [polypeptide binding]; other site
240292009862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292009863	TPR repeat; Region: TPR_11; pfam13414
240292009864	binding surface
240292009865	TPR motif; other site
240292009866	phosphodiesterase YaeI; Provisional; Region: PRK11340
240292009867	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
240292009868	putative active site [active]
240292009869	putative metal binding site [ion binding]; other site
240292009870	phosphodiesterase YaeI; Provisional; Region: PRK11340
240292009871	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
240292009872	putative active site [active]
240292009873	putative metal binding site [ion binding]; other site
240292009874	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
240292009875	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
240292009876	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292009877	TrkA-N domain; Region: TrkA_N; pfam02254
240292009878	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
240292009879	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
240292009880	heme bL binding site [chemical binding]; other site
240292009881	interchain domain interface [polypeptide binding]; other site
240292009882	intrachain domain interface; other site
240292009883	heme bH binding site [chemical binding]; other site
240292009884	Qo binding site; other site
240292009885	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
240292009886	PGAP1-like protein; Region: PGAP1; pfam07819
240292009887	Cytochrome c; Region: Cytochrom_C; cl11414
240292009888	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240292009889	plastocyanin; Provisional; Region: PRK02710
240292009890	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
240292009891	cytochrome c-550; Provisional; Region: psbV; PRK13618
240292009892	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
240292009893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292009894	dimer interface [polypeptide binding]; other site
240292009895	conserved gate region; other site
240292009896	putative PBP binding loops; other site
240292009897	ABC-ATPase subunit interface; other site
240292009898	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
240292009899	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
240292009900	tetramer interface [polypeptide binding]; other site
240292009901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292009902	catalytic residue [active]
240292009903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292009904	AAA domain; Region: AAA_18; pfam13238
240292009905	Walker A motif; other site
240292009906	ATP binding site [chemical binding]; other site
240292009907	Walker B motif; other site
240292009908	arginine finger; other site
240292009909	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292009910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292009911	active site
240292009912	phosphorylation site [posttranslational modification]
240292009913	intermolecular recognition site; other site
240292009914	dimerization interface [polypeptide binding]; other site
240292009915	Uncharacterized conserved protein [Function unknown]; Region: COG0398
240292009916	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
240292009917	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
240292009918	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
240292009919	C-terminal domain interface [polypeptide binding]; other site
240292009920	active site
240292009921	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
240292009922	active site
240292009923	N-terminal domain interface [polypeptide binding]; other site
240292009924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292009925	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292009926	putative substrate translocation pore; other site
240292009927	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
240292009928	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
240292009929	PYR/PP interface [polypeptide binding]; other site
240292009930	dimer interface [polypeptide binding]; other site
240292009931	TPP binding site [chemical binding]; other site
240292009932	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240292009933	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
240292009934	TPP-binding site [chemical binding]; other site
240292009935	dimer interface [polypeptide binding]; other site
240292009936	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292009937	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
240292009938	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292009939	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292009940	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292009941	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
240292009942	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
240292009943	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
240292009944	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
240292009945	lipoyl attachment site [posttranslational modification]; other site
240292009946	glycine dehydrogenase; Provisional; Region: PRK05367
240292009947	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
240292009948	tetramer interface [polypeptide binding]; other site
240292009949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292009950	catalytic residue [active]
240292009951	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
240292009952	tetramer interface [polypeptide binding]; other site
240292009953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292009954	catalytic residue [active]
240292009955	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292009956	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292009957	Predicted membrane protein [Function unknown]; Region: COG1981
240292009958	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
240292009959	Domain of unknown function DUF21; Region: DUF21; pfam01595
240292009960	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
240292009961	Transporter associated domain; Region: CorC_HlyC; smart01091
240292009962	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
240292009963	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
240292009964	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292009965	ATP binding site [chemical binding]; other site
240292009966	putative Mg++ binding site [ion binding]; other site
240292009967	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292009968	nucleotide binding region [chemical binding]; other site
240292009969	ATP-binding site [chemical binding]; other site
240292009970	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
240292009971	alpha-glucosidase; Provisional; Region: PRK10137
240292009972	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
240292009973	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292009974	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292009975	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292009976	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
240292009977	PAS fold; Region: PAS_4; pfam08448
240292009978	PAS fold; Region: PAS_4; pfam08448
240292009979	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292009980	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292009981	PAS fold; Region: PAS_4; pfam08448
240292009982	PAS domain S-box; Region: sensory_box; TIGR00229
240292009983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292009984	putative active site [active]
240292009985	heme pocket [chemical binding]; other site
240292009986	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292009987	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292009988	GAF domain; Region: GAF; pfam01590
240292009989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292009990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292009991	dimer interface [polypeptide binding]; other site
240292009992	phosphorylation site [posttranslational modification]
240292009993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292009994	ATP binding site [chemical binding]; other site
240292009995	Mg2+ binding site [ion binding]; other site
240292009996	G-X-G motif; other site
240292009997	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292009998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292009999	active site
240292010000	phosphorylation site [posttranslational modification]
240292010001	intermolecular recognition site; other site
240292010002	dimerization interface [polypeptide binding]; other site
240292010003	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292010004	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292010005	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292010006	transferase, transferring glycosyl groups; Region: PLN02939
240292010007	alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902
240292010008	Uncharacterized conserved protein [Function unknown]; Region: COG0398
240292010009	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
240292010010	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
240292010011	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
240292010012	Catalytic site; other site
240292010013	proline aminopeptidase P II; Provisional; Region: PRK10879
240292010014	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
240292010015	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
240292010016	active site
240292010017	Family description; Region: VCBS; pfam13517
240292010018	Family description; Region: VCBS; pfam13517
240292010019	Family description; Region: VCBS; pfam13517
240292010020	Family description; Region: VCBS; pfam13517
240292010021	Family description; Region: VCBS; pfam13517
240292010022	Family description; Region: VCBS; pfam13517
240292010023	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240292010024	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
240292010025	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
240292010026	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
240292010027	glutamine binding [chemical binding]; other site
240292010028	catalytic triad [active]
240292010029	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
240292010030	metal-binding heat shock protein; Provisional; Region: PRK00016
240292010031	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
240292010032	This domain is found in peptide chain release factors; Region: PCRF; smart00937
240292010033	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
240292010034	RF-1 domain; Region: RF-1; pfam00472
240292010035	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
240292010036	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
240292010037	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
240292010038	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
240292010039	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
240292010040	active site
240292010041	dimer interface [polypeptide binding]; other site
240292010042	motif 1; other site
240292010043	motif 2; other site
240292010044	motif 3; other site
240292010045	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
240292010046	anticodon binding site; other site
240292010047	AAA ATPase domain; Region: AAA_16; pfam13191
240292010048	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
240292010049	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
240292010050	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
240292010051	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292010052	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010053	active site
240292010054	substrate binding site [chemical binding]; other site
240292010055	ATP binding site [chemical binding]; other site
240292010056	activation loop (A-loop); other site
240292010057	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
240292010058	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
240292010059	putative ligand binding site [chemical binding]; other site
240292010060	homoserine kinase; Provisional; Region: PRK01212
240292010061	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
240292010062	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
240292010063	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292010064	2TM domain; Region: 2TM; pfam13239
240292010065	acyl carrier protein; Provisional; Region: acpP; PRK00982
240292010066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
240292010067	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240292010068	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
240292010069	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
240292010070	NADP binding site [chemical binding]; other site
240292010071	substrate binding site [chemical binding]; other site
240292010072	active site
240292010073	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240292010074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292010075	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
240292010076	substrate binding pocket [chemical binding]; other site
240292010077	dimerization interface [polypeptide binding]; other site
240292010078	Protein kinase domain; Region: Pkinase; pfam00069
240292010079	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010080	active site
240292010081	ATP binding site [chemical binding]; other site
240292010082	substrate binding site [chemical binding]; other site
240292010083	activation loop (A-loop); other site
240292010084	AAA ATPase domain; Region: AAA_16; pfam13191
240292010085	Predicted ATPase [General function prediction only]; Region: COG3899
240292010086	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010087	GAF domain; Region: GAF; pfam01590
240292010088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292010089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010090	ATP binding site [chemical binding]; other site
240292010091	Mg2+ binding site [ion binding]; other site
240292010092	G-X-G motif; other site
240292010093	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
240292010094	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292010095	FeS/SAM binding site; other site
240292010096	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292010097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010098	active site
240292010099	phosphorylation site [posttranslational modification]
240292010100	intermolecular recognition site; other site
240292010101	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292010102	CHASE2 domain; Region: CHASE2; pfam05226
240292010103	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292010104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
240292010105	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292010106	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292010107	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292010108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292010109	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292010110	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010111	active site
240292010112	ATP binding site [chemical binding]; other site
240292010113	substrate binding site [chemical binding]; other site
240292010114	activation loop (A-loop); other site
240292010115	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292010116	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
240292010117	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292010118	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
240292010119	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292010120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292010121	putative substrate translocation pore; other site
240292010122	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
240292010123	MarR family; Region: MarR; pfam01047
240292010124	YwiC-like protein; Region: YwiC; pfam14256
240292010125	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292010126	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010127	structural tetrad; other site
240292010128	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010129	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010130	structural tetrad; other site
240292010131	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
240292010132	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
240292010133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292010134	catalytic residue [active]
240292010135	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
240292010136	RuvA N terminal domain; Region: RuvA_N; pfam01330
240292010137	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
240292010138	sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485
240292010139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
240292010140	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
240292010141	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
240292010142	Nucleoside recognition; Region: Gate; pfam07670
240292010143	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
240292010144	cobalamin synthase; Reviewed; Region: cobS; PRK00235
240292010145	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
240292010146	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
240292010147	active site residue [active]
240292010148	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292010149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292010150	S-adenosylmethionine binding site [chemical binding]; other site
240292010151	Phosphate acyltransferases; Region: PlsC; smart00563
240292010152	putative acyl-acceptor binding pocket; other site
240292010153	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
240292010154	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292010155	ABC-ATPase subunit  interface; other site
240292010156	dimer interface [polypeptide binding]; other site
240292010157	putative PBP binding regions; other site
240292010158	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
240292010159	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292010160	ABC-ATPase subunit  interface; other site
240292010161	dimer interface [polypeptide binding]; other site
240292010162	putative PBP binding regions; other site
240292010163	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
240292010164	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
240292010165	siderophore binding site; other site
240292010166	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
240292010167	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
240292010168	Walker A/P-loop; other site
240292010169	ATP binding site [chemical binding]; other site
240292010170	Q-loop/lid; other site
240292010171	ABC transporter signature motif; other site
240292010172	Walker B; other site
240292010173	D-loop; other site
240292010174	H-loop/switch region; other site
240292010175	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
240292010176	putative dimer interface [polypeptide binding]; other site
240292010177	putative [2Fe-2S] cluster binding site [ion binding]; other site
240292010178	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240292010179	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
240292010180	substrate binding pocket [chemical binding]; other site
240292010181	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
240292010182	IucA / IucC family; Region: IucA_IucC; pfam04183
240292010183	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
240292010184	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
240292010185	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
240292010186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292010187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292010188	putative substrate translocation pore; other site
240292010189	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
240292010190	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292010191	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
240292010192	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
240292010193	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
240292010194	IucA / IucC family; Region: IucA_IucC; pfam04183
240292010195	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
240292010196	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
240292010197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292010198	catalytic residue [active]
240292010199	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
240292010200	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292010201	inhibitor-cofactor binding pocket; inhibition site
240292010202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292010203	catalytic residue [active]
240292010204	AMIN domain; Region: AMIN; pfam11741
240292010205	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240292010206	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292010207	N-terminal plug; other site
240292010208	ligand-binding site [chemical binding]; other site
240292010209	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
240292010210	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
240292010211	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
240292010212	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
240292010213	Protein kinase domain; Region: Pkinase; pfam00069
240292010214	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010215	active site
240292010216	ATP binding site [chemical binding]; other site
240292010217	substrate binding site [chemical binding]; other site
240292010218	activation loop (A-loop); other site
240292010219	AAA ATPase domain; Region: AAA_16; pfam13191
240292010220	Predicted ATPase [General function prediction only]; Region: COG3899
240292010221	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010222	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292010223	PAS fold; Region: PAS_3; pfam08447
240292010224	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010225	putative active site [active]
240292010226	heme pocket [chemical binding]; other site
240292010227	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292010228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010229	ATP binding site [chemical binding]; other site
240292010230	Mg2+ binding site [ion binding]; other site
240292010231	G-X-G motif; other site
240292010232	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
240292010233	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
240292010234	active site
240292010235	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
240292010236	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
240292010237	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010238	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292010239	active site
240292010240	ATP binding site [chemical binding]; other site
240292010241	substrate binding site [chemical binding]; other site
240292010242	activation loop (A-loop); other site
240292010243	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010244	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010245	structural tetrad; other site
240292010246	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240292010247	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292010248	Walker A/P-loop; other site
240292010249	ATP binding site [chemical binding]; other site
240292010250	Q-loop/lid; other site
240292010251	ABC transporter signature motif; other site
240292010252	Walker B; other site
240292010253	D-loop; other site
240292010254	H-loop/switch region; other site
240292010255	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292010256	TrkA-N domain; Region: TrkA_N; pfam02254
240292010257	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
240292010258	TrkA-N domain; Region: TrkA_N; pfam02254
240292010259	DNA gyrase subunit A; Validated; Region: PRK05560
240292010260	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
240292010261	CAP-like domain; other site
240292010262	active site
240292010263	primary dimer interface [polypeptide binding]; other site
240292010264	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292010265	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292010266	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292010267	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292010268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010269	active site
240292010270	phosphorylation site [posttranslational modification]
240292010271	intermolecular recognition site; other site
240292010272	dimerization interface [polypeptide binding]; other site
240292010273	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010274	binding surface
240292010275	TPR motif; other site
240292010276	TPR repeat; Region: TPR_11; pfam13414
240292010277	TPR repeat; Region: TPR_11; pfam13414
240292010278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010279	binding surface
240292010280	TPR motif; other site
240292010281	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240292010282	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240292010283	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292010284	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292010285	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240292010286	FtsX-like permease family; Region: FtsX; pfam02687
240292010287	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240292010288	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292010289	Walker A/P-loop; other site
240292010290	ATP binding site [chemical binding]; other site
240292010291	Q-loop/lid; other site
240292010292	ABC transporter signature motif; other site
240292010293	Walker B; other site
240292010294	D-loop; other site
240292010295	H-loop/switch region; other site
240292010296	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240292010297	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292010298	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292010299	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292010300	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240292010301	FtsX-like permease family; Region: FtsX; pfam02687
240292010302	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
240292010303	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
240292010304	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
240292010305	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
240292010306	active site
240292010307	SAM binding site [chemical binding]; other site
240292010308	homodimer interface [polypeptide binding]; other site
240292010309	Divergent AAA domain; Region: AAA_4; pfam04326
240292010310	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
240292010311	active site
240292010312	SAM binding site [chemical binding]; other site
240292010313	homodimer interface [polypeptide binding]; other site
240292010314	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
240292010315	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292010316	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292010317	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
240292010318	Precorrin-8X methylmutase; Region: CbiC; pfam02570
240292010319	ChaB; Region: ChaB; pfam06150
240292010320	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
240292010321	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
240292010322	dimerization interface [polypeptide binding]; other site
240292010323	DPS ferroxidase diiron center [ion binding]; other site
240292010324	ion pore; other site
240292010325	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
240292010326	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
240292010327	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
240292010328	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
240292010329	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
240292010330	FAD binding pocket [chemical binding]; other site
240292010331	FAD binding motif [chemical binding]; other site
240292010332	phosphate binding motif [ion binding]; other site
240292010333	beta-alpha-beta structure motif; other site
240292010334	NAD binding pocket [chemical binding]; other site
240292010335	PHP-associated; Region: PHP_C; pfam13263
240292010336	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
240292010337	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240292010338	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240292010339	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240292010340	Family of unknown function (DUF490); Region: DUF490; pfam04357
240292010341	AAA-like domain; Region: AAA_10; pfam12846
240292010342	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
240292010343	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
240292010344	putative NAD(P) binding site [chemical binding]; other site
240292010345	homodimer interface [polypeptide binding]; other site
240292010346	homotetramer interface [polypeptide binding]; other site
240292010347	active site
240292010348	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
240292010349	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
240292010350	active site
240292010351	homodimer interface [polypeptide binding]; other site
240292010352	AAA ATPase domain; Region: AAA_16; pfam13191
240292010353	Walker A motif; other site
240292010354	ATP binding site [chemical binding]; other site
240292010355	WD domain, G-beta repeat; Region: WD40; pfam00400
240292010356	WD40 repeats; Region: WD40; smart00320
240292010357	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010358	structural tetrad; other site
240292010359	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010360	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010361	structural tetrad; other site
240292010362	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
240292010363	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292010364	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
240292010365	putative NAD(P) binding site [chemical binding]; other site
240292010366	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
240292010367	hydrophobic ligand binding site; other site
240292010368	GTP-binding protein Der; Reviewed; Region: PRK00093
240292010369	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
240292010370	G1 box; other site
240292010371	GTP/Mg2+ binding site [chemical binding]; other site
240292010372	Switch I region; other site
240292010373	G2 box; other site
240292010374	Switch II region; other site
240292010375	G3 box; other site
240292010376	G4 box; other site
240292010377	G5 box; other site
240292010378	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
240292010379	G1 box; other site
240292010380	GTP/Mg2+ binding site [chemical binding]; other site
240292010381	Switch I region; other site
240292010382	G2 box; other site
240292010383	G3 box; other site
240292010384	Switch II region; other site
240292010385	G4 box; other site
240292010386	G5 box; other site
240292010387	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
240292010388	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
240292010389	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
240292010390	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240292010391	catalytic residue [active]
240292010392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
240292010393	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
240292010394	pyrroline-5-carboxylate reductase; Region: PLN02688
240292010395	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
240292010396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292010397	ATP binding site [chemical binding]; other site
240292010398	putative Mg++ binding site [ion binding]; other site
240292010399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292010400	nucleotide binding region [chemical binding]; other site
240292010401	ATP-binding site [chemical binding]; other site
240292010402	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
240292010403	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292010404	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292010405	active site
240292010406	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292010407	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
240292010408	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
240292010409	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
240292010410	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
240292010411	membrane protein; Provisional; Region: PRK14419
240292010412	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292010413	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240292010414	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292010415	Nucleotide binding site [chemical binding]; other site
240292010416	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240292010417	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
240292010418	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240292010419	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
240292010420	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
240292010421	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
240292010422	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
240292010423	inhibitor-cofactor binding pocket; inhibition site
240292010424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292010425	catalytic residue [active]
240292010426	Uncharacterized metal-binding protein [General function prediction only]; Region: COG2389
240292010427	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
240292010428	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
240292010429	homodimer interface [polypeptide binding]; other site
240292010430	metal binding site [ion binding]; metal-binding site
240292010431	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
240292010432	homodimer interface [polypeptide binding]; other site
240292010433	active site
240292010434	putative chemical substrate binding site [chemical binding]; other site
240292010435	metal binding site [ion binding]; metal-binding site
240292010436	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
240292010437	putative catalytic residue [active]
240292010438	light-harvesting-like protein 3; Provisional; Region: PLN00014
240292010439	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
240292010440	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240292010441	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
240292010442	putative substrate binding site [chemical binding]; other site
240292010443	putative ATP binding site [chemical binding]; other site
240292010444	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
240292010445	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
240292010446	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
240292010447	putative active site [active]
240292010448	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
240292010449	putative active site [active]
240292010450	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
240292010451	active site
240292010452	SAM binding site [chemical binding]; other site
240292010453	homodimer interface [polypeptide binding]; other site
240292010454	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
240292010455	Response regulator receiver domain; Region: Response_reg; pfam00072
240292010456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010457	active site
240292010458	phosphorylation site [posttranslational modification]
240292010459	intermolecular recognition site; other site
240292010460	dimerization interface [polypeptide binding]; other site
240292010461	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
240292010462	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292010463	RNA binding surface [nucleotide binding]; other site
240292010464	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
240292010465	active site
240292010466	Phycobilisome protein; Region: Phycobilisome; cl08227
240292010467	Phycobilisome protein; Region: Phycobilisome; cl08227
240292010468	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010469	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
240292010470	HEAT repeats; Region: HEAT_2; pfam13646
240292010471	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292010472	HEAT repeats; Region: HEAT_2; pfam13646
240292010473	HEAT repeats; Region: HEAT_2; pfam13646
240292010474	phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339
240292010475	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
240292010476	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010477	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
240292010478	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
240292010479	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
240292010480	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292010481	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292010482	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
240292010483	HEAT repeats; Region: HEAT_2; pfam13646
240292010484	HEAT repeats; Region: HEAT_2; pfam13646
240292010485	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010486	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010487	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010488	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
240292010489	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
240292010490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292010491	S-adenosylmethionine binding site [chemical binding]; other site
240292010492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
240292010493	Proline dehydrogenase; Region: Pro_dh; pfam01619
240292010494	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
240292010495	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
240292010496	Glutamate binding site [chemical binding]; other site
240292010497	homodimer interface [polypeptide binding]; other site
240292010498	NAD binding site [chemical binding]; other site
240292010499	catalytic residues [active]
240292010500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292010501	Coenzyme A binding pocket [chemical binding]; other site
240292010502	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010503	GAF domain; Region: GAF; pfam01590
240292010504	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292010505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010506	putative active site [active]
240292010507	heme pocket [chemical binding]; other site
240292010508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292010509	dimer interface [polypeptide binding]; other site
240292010510	phosphorylation site [posttranslational modification]
240292010511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010512	ATP binding site [chemical binding]; other site
240292010513	Mg2+ binding site [ion binding]; other site
240292010514	G-X-G motif; other site
240292010515	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
240292010516	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
240292010517	cobalamin binding residues [chemical binding]; other site
240292010518	putative BtuC binding residues; other site
240292010519	dimer interface [polypeptide binding]; other site
240292010520	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
240292010521	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
240292010522	active site
240292010523	Zn binding site [ion binding]; other site
240292010524	Uncharacterized conserved protein [Function unknown]; Region: COG2947
240292010525	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
240292010526	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
240292010527	Domain of unknown function (DUF897); Region: DUF897; pfam05982
240292010528	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
240292010529	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
240292010530	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
240292010531	active site
240292010532	dimer interface [polypeptide binding]; other site
240292010533	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
240292010534	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
240292010535	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
240292010536	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
240292010537	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
240292010538	active site
240292010539	catalytic triad [active]
240292010540	oxyanion hole [active]
240292010541	Phytochelatin synthase; Region: Phytochelatin; pfam05023
240292010542	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
240292010543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292010544	dimer interface [polypeptide binding]; other site
240292010545	conserved gate region; other site
240292010546	ABC-ATPase subunit interface; other site
240292010547	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
240292010548	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
240292010549	Walker A/P-loop; other site
240292010550	ATP binding site [chemical binding]; other site
240292010551	Q-loop/lid; other site
240292010552	ABC transporter signature motif; other site
240292010553	Walker B; other site
240292010554	D-loop; other site
240292010555	H-loop/switch region; other site
240292010556	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
240292010557	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292010558	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240292010559	Walker A/P-loop; other site
240292010560	ATP binding site [chemical binding]; other site
240292010561	Q-loop/lid; other site
240292010562	ABC transporter signature motif; other site
240292010563	Walker B; other site
240292010564	D-loop; other site
240292010565	H-loop/switch region; other site
240292010566	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
240292010567	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
240292010568	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292010569	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
240292010570	classical (c) SDRs; Region: SDR_c; cd05233
240292010571	NAD(P) binding site [chemical binding]; other site
240292010572	active site
240292010573	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
240292010574	active site
240292010575	catalytic site [active]
240292010576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
240292010577	SPFH domain / Band 7 family; Region: Band_7; pfam01145
240292010578	Transposase domain (DUF772); Region: DUF772; pfam05598
240292010579	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292010580	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010581	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010582	structural tetrad; other site
240292010583	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010584	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010585	structural tetrad; other site
240292010586	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010587	structural tetrad; other site
240292010588	CHAT domain; Region: CHAT; cl17868
240292010589	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
240292010590	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010591	binding surface
240292010592	TPR motif; other site
240292010593	TPR repeat; Region: TPR_11; pfam13414
240292010594	TPR repeat; Region: TPR_11; pfam13414
240292010595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010596	binding surface
240292010597	TPR motif; other site
240292010598	TPR repeat; Region: TPR_11; pfam13414
240292010599	KTSC domain; Region: KTSC; pfam13619
240292010600	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292010601	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240292010602	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292010603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292010604	Coenzyme A binding pocket [chemical binding]; other site
240292010605	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292010606	Fasciclin domain; Region: Fasciclin; pfam02469
240292010607	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
240292010608	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
240292010609	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
240292010610	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
240292010611	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240292010612	active site
240292010613	HIGH motif; other site
240292010614	nucleotide binding site [chemical binding]; other site
240292010615	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
240292010616	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
240292010617	active site
240292010618	KMSKS motif; other site
240292010619	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
240292010620	tRNA binding surface [nucleotide binding]; other site
240292010621	anticodon binding site; other site
240292010622	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
240292010623	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
240292010624	Predicted membrane protein [Function unknown]; Region: COG5305
240292010625	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
240292010626	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
240292010627	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
240292010628	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
240292010629	tartrate dehydrogenase; Region: TTC; TIGR02089
240292010630	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
240292010631	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292010632	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010633	active site
240292010634	ATP binding site [chemical binding]; other site
240292010635	substrate binding site [chemical binding]; other site
240292010636	activation loop (A-loop); other site
240292010637	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292010638	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010639	active site
240292010640	ATP binding site [chemical binding]; other site
240292010641	substrate binding site [chemical binding]; other site
240292010642	activation loop (A-loop); other site
240292010643	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
240292010644	FAD binding site [chemical binding]; other site
240292010645	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
240292010646	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
240292010647	active site
240292010648	HIGH motif; other site
240292010649	dimer interface [polypeptide binding]; other site
240292010650	KMSKS motif; other site
240292010651	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
240292010652	TAP-like protein; Region: Abhydrolase_4; pfam08386
240292010653	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
240292010654	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
240292010655	putative homodimer interface [polypeptide binding]; other site
240292010656	putative active site pocket [active]
240292010657	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
240292010658	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
240292010659	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
240292010660	trimer interface [polypeptide binding]; other site
240292010661	active site
240292010662	substrate binding site [chemical binding]; other site
240292010663	CoA binding site [chemical binding]; other site
240292010664	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
240292010665	OstA-like protein; Region: OstA; cl00844
240292010666	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
240292010667	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292010668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010669	active site
240292010670	phosphorylation site [posttranslational modification]
240292010671	intermolecular recognition site; other site
240292010672	dimerization interface [polypeptide binding]; other site
240292010673	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292010674	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010675	putative active site [active]
240292010676	heme pocket [chemical binding]; other site
240292010677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292010678	dimer interface [polypeptide binding]; other site
240292010679	phosphorylation site [posttranslational modification]
240292010680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010681	ATP binding site [chemical binding]; other site
240292010682	Mg2+ binding site [ion binding]; other site
240292010683	G-X-G motif; other site
240292010684	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010685	GAF domain; Region: GAF; pfam01590
240292010686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010687	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292010688	putative active site [active]
240292010689	heme pocket [chemical binding]; other site
240292010690	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292010691	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010692	putative active site [active]
240292010693	heme pocket [chemical binding]; other site
240292010694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010695	putative active site [active]
240292010696	heme pocket [chemical binding]; other site
240292010697	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010698	GAF domain; Region: GAF; pfam01590
240292010699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292010700	Histidine kinase; Region: HisKA_2; pfam07568
240292010701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010702	ATP binding site [chemical binding]; other site
240292010703	Mg2+ binding site [ion binding]; other site
240292010704	G-X-G motif; other site
240292010705	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292010706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010707	active site
240292010708	phosphorylation site [posttranslational modification]
240292010709	intermolecular recognition site; other site
240292010710	dimerization interface [polypeptide binding]; other site
240292010711	lipoyl synthase; Provisional; Region: PRK12928
240292010712	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292010713	FeS/SAM binding site; other site
240292010714	PsaX family; Region: PsaX; pfam08078
240292010715	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
240292010716	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
240292010717	TM-ABC transporter signature motif; other site
240292010718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292010719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292010720	dimer interface [polypeptide binding]; other site
240292010721	phosphorylation site [posttranslational modification]
240292010722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010723	ATP binding site [chemical binding]; other site
240292010724	Mg2+ binding site [ion binding]; other site
240292010725	G-X-G motif; other site
240292010726	Response regulator receiver domain; Region: Response_reg; pfam00072
240292010727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010728	active site
240292010729	phosphorylation site [posttranslational modification]
240292010730	intermolecular recognition site; other site
240292010731	dimerization interface [polypeptide binding]; other site
240292010732	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
240292010733	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
240292010734	Ligand Binding Site [chemical binding]; other site
240292010735	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
240292010736	active site
240292010737	catalytic triad [active]
240292010738	oxyanion hole [active]
240292010739	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
240292010740	DNA methylase; Region: N6_N4_Mtase; pfam01555
240292010741	cyanate hydratase; Validated; Region: PRK02866
240292010742	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
240292010743	oligomer interface [polypeptide binding]; other site
240292010744	active site
240292010745	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292010746	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292010747	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240292010748	Walker A/P-loop; other site
240292010749	ATP binding site [chemical binding]; other site
240292010750	Q-loop/lid; other site
240292010751	ABC transporter signature motif; other site
240292010752	Walker B; other site
240292010753	D-loop; other site
240292010754	H-loop/switch region; other site
240292010755	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240292010756	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
240292010757	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
240292010758	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
240292010759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292010760	Walker A/P-loop; other site
240292010761	ATP binding site [chemical binding]; other site
240292010762	Q-loop/lid; other site
240292010763	ABC transporter signature motif; other site
240292010764	Walker B; other site
240292010765	D-loop; other site
240292010766	H-loop/switch region; other site
240292010767	ABC transporter; Region: ABC_tran_2; pfam12848
240292010768	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240292010769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292010770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292010771	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
240292010772	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
240292010773	intersubunit interface [polypeptide binding]; other site
240292010774	ATP-grasp domain; Region: ATP-grasp; pfam02222
240292010775	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
240292010776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
240292010777	Predicted permease [General function prediction only]; Region: COG3329
240292010778	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292010779	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240292010780	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292010781	GAF domain; Region: GAF_3; pfam13492
240292010782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292010783	dimer interface [polypeptide binding]; other site
240292010784	phosphorylation site [posttranslational modification]
240292010785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010786	ATP binding site [chemical binding]; other site
240292010787	Mg2+ binding site [ion binding]; other site
240292010788	G-X-G motif; other site
240292010789	NifU-like domain; Region: NifU; pfam01106
240292010790	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
240292010791	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
240292010792	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
240292010793	putative active site [active]
240292010794	catalytic site [active]
240292010795	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292010796	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292010797	active site
240292010798	ATP binding site [chemical binding]; other site
240292010799	substrate binding site [chemical binding]; other site
240292010800	activation loop (A-loop); other site
240292010801	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
240292010802	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
240292010803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292010804	FeS/SAM binding site; other site
240292010805	TRAM domain; Region: TRAM; pfam01938
240292010806	Protein of unknown function (DUF433); Region: DUF433; pfam04255
240292010807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
240292010808	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
240292010809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
240292010810	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
240292010811	FOG: CBS domain [General function prediction only]; Region: COG0517
240292010812	PAS domain S-box; Region: sensory_box; TIGR00229
240292010813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010814	putative active site [active]
240292010815	heme pocket [chemical binding]; other site
240292010816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010817	PAS fold; Region: PAS_3; pfam08447
240292010818	putative active site [active]
240292010819	heme pocket [chemical binding]; other site
240292010820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010821	PAS domain; Region: PAS_9; pfam13426
240292010822	putative active site [active]
240292010823	heme pocket [chemical binding]; other site
240292010824	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292010825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292010826	putative active site [active]
240292010827	heme pocket [chemical binding]; other site
240292010828	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292010829	dimer interface [polypeptide binding]; other site
240292010830	phosphorylation site [posttranslational modification]
240292010831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292010832	ATP binding site [chemical binding]; other site
240292010833	Mg2+ binding site [ion binding]; other site
240292010834	G-X-G motif; other site
240292010835	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292010836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292010837	active site
240292010838	phosphorylation site [posttranslational modification]
240292010839	intermolecular recognition site; other site
240292010840	dimerization interface [polypeptide binding]; other site
240292010841	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
240292010842	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
240292010843	active site
240292010844	ADP/pyrophosphate binding site [chemical binding]; other site
240292010845	dimerization interface [polypeptide binding]; other site
240292010846	allosteric effector site; other site
240292010847	fructose-1,6-bisphosphate binding site; other site
240292010848	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
240292010849	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
240292010850	putative active site [active]
240292010851	putative FMN binding site [chemical binding]; other site
240292010852	putative substrate binding site [chemical binding]; other site
240292010853	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
240292010854	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
240292010855	dimer interface [polypeptide binding]; other site
240292010856	PYR/PP interface [polypeptide binding]; other site
240292010857	TPP binding site [chemical binding]; other site
240292010858	substrate binding site [chemical binding]; other site
240292010859	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
240292010860	Domain of unknown function; Region: EKR; smart00890
240292010861	4Fe-4S binding domain; Region: Fer4_6; pfam12837
240292010862	4Fe-4S binding domain; Region: Fer4; pfam00037
240292010863	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
240292010864	TPP-binding site [chemical binding]; other site
240292010865	dimer interface [polypeptide binding]; other site
240292010866	Putative phosphatase (DUF442); Region: DUF442; cl17385
240292010867	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
240292010868	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
240292010869	Chromate transporter; Region: Chromate_transp; pfam02417
240292010870	Putative phosphatase (DUF442); Region: DUF442; cl17385
240292010871	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
240292010872	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
240292010873	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
240292010874	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
240292010875	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
240292010876	N-acetyl-D-glucosamine binding site [chemical binding]; other site
240292010877	catalytic residue [active]
240292010878	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
240292010879	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
240292010880	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
240292010881	substrate binding pocket [chemical binding]; other site
240292010882	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
240292010883	B12 binding site [chemical binding]; other site
240292010884	cobalt ligand [ion binding]; other site
240292010885	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
240292010886	Transposase domain (DUF772); Region: DUF772; pfam05598
240292010887	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292010888	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292010889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010890	binding surface
240292010891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292010892	TPR motif; other site
240292010893	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292010894	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292010895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292010896	TPR motif; other site
240292010897	binding surface
240292010898	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
240292010899	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
240292010900	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292010901	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292010902	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292010903	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292010904	active site
240292010905	catalytic tetrad [active]
240292010906	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
240292010907	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
240292010908	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
240292010909	active site pocket [active]
240292010910	putative dimer interface [polypeptide binding]; other site
240292010911	putative cataytic base [active]
240292010912	Predicted membrane protein [Function unknown]; Region: COG4241
240292010913	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292010914	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292010915	ligand binding site [chemical binding]; other site
240292010916	flexible hinge region; other site
240292010917	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292010918	putative switch regulator; other site
240292010919	non-specific DNA interactions [nucleotide binding]; other site
240292010920	DNA binding site [nucleotide binding]
240292010921	sequence specific DNA binding site [nucleotide binding]; other site
240292010922	putative cAMP binding site [chemical binding]; other site
240292010923	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240292010924	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
240292010925	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292010926	Coenzyme A binding pocket [chemical binding]; other site
240292010927	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
240292010928	active site
240292010929	dimerization interface [polypeptide binding]; other site
240292010930	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292010931	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292010932	DNA binding residues [nucleotide binding]
240292010933	dimerization interface [polypeptide binding]; other site
240292010934	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292010935	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240292010936	protein binding site [polypeptide binding]; other site
240292010937	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
240292010938	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292010939	motif II; other site
240292010940	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
240292010941	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
240292010942	active site
240292010943	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
240292010944	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
240292010945	putative dimer interface [polypeptide binding]; other site
240292010946	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
240292010947	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
240292010948	Caspase domain; Region: Peptidase_C14; pfam00656
240292010949	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010950	structural tetrad; other site
240292010951	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010952	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010953	structural tetrad; other site
240292010954	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
240292010955	Caspase domain; Region: Peptidase_C14; pfam00656
240292010956	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010957	structural tetrad; other site
240292010958	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292010959	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010960	structural tetrad; other site
240292010961	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292010962	structural tetrad; other site
240292010963	Propionate catabolism activator; Region: PrpR_N; pfam06506
240292010964	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
240292010965	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
240292010966	dimerization interface [polypeptide binding]; other site
240292010967	active site
240292010968	metal binding site [ion binding]; metal-binding site
240292010969	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
240292010970	LabA_like proteins; Region: LabA_like; cd06167
240292010971	putative metal binding site [ion binding]; other site
240292010972	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292010973	putative active site [active]
240292010974	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
240292010975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292010976	Walker A motif; other site
240292010977	ATP binding site [chemical binding]; other site
240292010978	Walker B motif; other site
240292010979	arginine finger; other site
240292010980	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
240292010981	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
240292010982	metal ion-dependent adhesion site (MIDAS); other site
240292010983	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
240292010984	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292010985	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240292010986	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
240292010987	DNA binding residues [nucleotide binding]
240292010988	putative cation:proton antiport protein; Provisional; Region: PRK10669
240292010989	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292010990	TrkA-N domain; Region: TrkA_N; pfam02254
240292010991	TrkA-C domain; Region: TrkA_C; pfam02080
240292010992	TrkA-C domain; Region: TrkA_C; pfam02080
240292010993	bacterial Hfq-like; Region: Hfq; cd01716
240292010994	hexamer interface [polypeptide binding]; other site
240292010995	Sm1 motif; other site
240292010996	RNA binding site [nucleotide binding]; other site
240292010997	Sm2 motif; other site
240292010998	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240292010999	diaminopimelate epimerase; Region: PLN02536
240292011000	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240292011001	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292011002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292011003	active site
240292011004	phosphorylation site [posttranslational modification]
240292011005	intermolecular recognition site; other site
240292011006	dimerization interface [polypeptide binding]; other site
240292011007	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
240292011008	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
240292011009	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292011010	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
240292011011	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
240292011012	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
240292011013	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
240292011014	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292011015	active site
240292011016	catalytic residues [active]
240292011017	DNA binding site [nucleotide binding]
240292011018	Int/Topo IB signature motif; other site
240292011019	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
240292011020	Virulence-associated protein E; Region: VirE; pfam05272
240292011021	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
240292011022	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292011023	active site
240292011024	DNA binding site [nucleotide binding]
240292011025	Int/Topo IB signature motif; other site
240292011026	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
240292011027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
240292011028	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292011029	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292011030	active site
240292011031	catalytic tetrad [active]
240292011032	hydrolase, alpha/beta fold family protein; Region: PLN02824
240292011033	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
240292011034	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292011035	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292011036	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292011037	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292011038	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292011039	Kelch motif; Region: Kelch_5; pfam13854
240292011040	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292011041	TrkA-N domain; Region: TrkA_N; pfam02254
240292011042	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292011043	TrkA-N domain; Region: TrkA_N; pfam02254
240292011044	TrkA-C domain; Region: TrkA_C; pfam02080
240292011045	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
240292011046	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
240292011047	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
240292011048	shikimate binding site; other site
240292011049	NAD(P) binding site [chemical binding]; other site
240292011050	YGGT family; Region: YGGT; pfam02325
240292011051	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292011052	active site
240292011053	carotene isomerase; Region: carot_isom; TIGR02730
240292011054	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292011055	hydroxyglutarate oxidase; Provisional; Region: PRK11728
240292011056	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292011057	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
240292011058	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
240292011059	threonine synthase; Reviewed; Region: PRK06721
240292011060	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
240292011061	homodimer interface [polypeptide binding]; other site
240292011062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292011063	catalytic residue [active]
240292011064	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
240292011065	heterotetramer interface [polypeptide binding]; other site
240292011066	active site pocket [active]
240292011067	cleavage site
240292011068	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
240292011069	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292011070	dimer interface [polypeptide binding]; other site
240292011071	putative metal binding site [ion binding]; other site
240292011072	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
240292011073	Resolvase, N terminal domain; Region: Resolvase; smart00857
240292011074	catalytic residues [active]
240292011075	Recombinase; Region: Recombinase; pfam07508
240292011076	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292011077	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240292011078	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240292011079	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240292011080	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
240292011081	Cl- selectivity filter; other site
240292011082	Cl- binding residues [ion binding]; other site
240292011083	pore gating glutamate residue; other site
240292011084	dimer interface [polypeptide binding]; other site
240292011085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
240292011086	FOG: CBS domain [General function prediction only]; Region: COG0517
240292011087	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
240292011088	Predicted transcriptional regulator [Transcription]; Region: COG1959
240292011089	Transcriptional regulator; Region: Rrf2; cl17282
240292011090	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
240292011091	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
240292011092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292011093	active site
240292011094	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
240292011095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292011096	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292011097	S-adenosylmethionine binding site [chemical binding]; other site
240292011098	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
240292011099	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292011100	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
240292011101	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
240292011102	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
240292011103	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
240292011104	S-layer homology domain; Region: SLH; pfam00395
240292011105	S-layer homology domain; Region: SLH; pfam00395
240292011106	S-layer homology domain; Region: SLH; pfam00395
240292011107	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
240292011108	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
240292011109	dimerization interface [polypeptide binding]; other site
240292011110	active site
240292011111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
240292011112	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
240292011113	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
240292011114	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
240292011115	active site
240292011116	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
240292011117	active site
240292011118	CHAT domain; Region: CHAT; cl17868
240292011119	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
240292011120	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
240292011121	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
240292011122	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
240292011123	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
240292011124	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292011125	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292011126	putative active site [active]
240292011127	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
240292011128	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
240292011129	dimer interface [polypeptide binding]; other site
240292011130	putative anticodon binding site; other site
240292011131	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
240292011132	motif 1; other site
240292011133	active site
240292011134	motif 2; other site
240292011135	motif 3; other site
240292011136	KTSC domain; Region: KTSC; pfam13619
240292011137	PIN domain; Region: PIN_3; cl17397
240292011138	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292011139	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
240292011140	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
240292011141	active site
240292011142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011143	binding surface
240292011144	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011145	TPR motif; other site
240292011146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292011147	binding surface
240292011148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011149	TPR motif; other site
240292011150	Uncharacterized conserved protein [Function unknown]; Region: COG5502
240292011151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292011152	dimer interface [polypeptide binding]; other site
240292011153	phosphorylation site [posttranslational modification]
240292011154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011155	ATP binding site [chemical binding]; other site
240292011156	Mg2+ binding site [ion binding]; other site
240292011157	G-X-G motif; other site
240292011158	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
240292011159	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
240292011160	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240292011161	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240292011162	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240292011163	polyphosphate kinase; Provisional; Region: PRK05443
240292011164	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
240292011165	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
240292011166	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
240292011167	putative domain interface [polypeptide binding]; other site
240292011168	putative active site [active]
240292011169	catalytic site [active]
240292011170	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
240292011171	putative domain interface [polypeptide binding]; other site
240292011172	putative active site [active]
240292011173	catalytic site [active]
240292011174	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292011175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292011176	active site
240292011177	phosphorylation site [posttranslational modification]
240292011178	intermolecular recognition site; other site
240292011179	dimerization interface [polypeptide binding]; other site
240292011180	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
240292011181	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
240292011182	Response regulator receiver domain; Region: Response_reg; pfam00072
240292011183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292011184	active site
240292011185	phosphorylation site [posttranslational modification]
240292011186	intermolecular recognition site; other site
240292011187	dimerization interface [polypeptide binding]; other site
240292011188	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292011189	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292011190	metal binding site [ion binding]; metal-binding site
240292011191	active site
240292011192	I-site; other site
240292011193	adaptive-response sensory kinase; Validated; Region: PRK09303
240292011194	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
240292011195	tetramer interface [polypeptide binding]; other site
240292011196	dimer interface [polypeptide binding]; other site
240292011197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292011198	dimer interface [polypeptide binding]; other site
240292011199	phosphorylation site [posttranslational modification]
240292011200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011201	ATP binding site [chemical binding]; other site
240292011202	Mg2+ binding site [ion binding]; other site
240292011203	G-X-G motif; other site
240292011204	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
240292011205	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
240292011206	acyl-activating enzyme (AAE) consensus motif; other site
240292011207	putative AMP binding site [chemical binding]; other site
240292011208	putative active site [active]
240292011209	putative CoA binding site [chemical binding]; other site
240292011210	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
240292011211	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
240292011212	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240292011213	E3 interaction surface; other site
240292011214	lipoyl attachment site [posttranslational modification]; other site
240292011215	e3 binding domain; Region: E3_binding; pfam02817
240292011216	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
240292011217	TPR repeat; Region: TPR_11; pfam13414
240292011218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011219	binding surface
240292011220	TPR motif; other site
240292011221	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011222	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
240292011223	S-layer homology domain; Region: SLH; pfam00395
240292011224	S-layer homology domain; Region: SLH; pfam00395
240292011225	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
240292011226	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
240292011227	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
240292011228	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292011229	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
240292011230	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
240292011231	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
240292011232	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
240292011233	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
240292011234	active site
240292011235	catalytic triad [active]
240292011236	oxyanion hole [active]
240292011237	S-layer homology domain; Region: SLH; pfam00395
240292011238	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
240292011239	MutS domain I; Region: MutS_I; pfam01624
240292011240	MutS domain II; Region: MutS_II; pfam05188
240292011241	MutS domain III; Region: MutS_III; pfam05192
240292011242	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
240292011243	Walker A/P-loop; other site
240292011244	ATP binding site [chemical binding]; other site
240292011245	Q-loop/lid; other site
240292011246	ABC transporter signature motif; other site
240292011247	Walker B; other site
240292011248	D-loop; other site
240292011249	H-loop/switch region; other site
240292011250	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292011251	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292011252	ligand binding site [chemical binding]; other site
240292011253	flexible hinge region; other site
240292011254	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292011255	putative switch regulator; other site
240292011256	non-specific DNA interactions [nucleotide binding]; other site
240292011257	DNA binding site [nucleotide binding]
240292011258	sequence specific DNA binding site [nucleotide binding]; other site
240292011259	putative cAMP binding site [chemical binding]; other site
240292011260	hybrid cluster protein; Provisional; Region: PRK05290
240292011261	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292011262	ACS interaction site; other site
240292011263	CODH interaction site; other site
240292011264	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
240292011265	hybrid metal cluster; other site
240292011266	Homeodomain-like domain; Region: HTH_23; pfam13384
240292011267	Winged helix-turn helix; Region: HTH_29; pfam13551
240292011268	Winged helix-turn helix; Region: HTH_33; pfam13592
240292011269	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292011270	cell division protein; Validated; Region: ftsH; CHL00176
240292011271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292011272	Walker A motif; other site
240292011273	ATP binding site [chemical binding]; other site
240292011274	Walker B motif; other site
240292011275	arginine finger; other site
240292011276	Peptidase family M41; Region: Peptidase_M41; pfam01434
240292011277	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
240292011278	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
240292011279	putative active site [active]
240292011280	Zn binding site [ion binding]; other site
240292011281	glutamate--cysteine ligase, cyanobacterial, putative; Region: gshA_cyano; TIGR02048
240292011282	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
240292011283	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240292011284	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292011285	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292011286	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
240292011287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292011288	S-adenosylmethionine binding site [chemical binding]; other site
240292011289	Peptidase family M48; Region: Peptidase_M48; cl12018
240292011290	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
240292011291	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
240292011292	Uncharacterized conserved protein [Function unknown]; Region: COG2898
240292011293	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
240292011294	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
240292011295	Putative esterase; Region: Esterase; pfam00756
240292011296	Putative esterase; Region: Esterase; pfam00756
240292011297	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292011298	Predicted integral membrane protein [Function unknown]; Region: COG0392
240292011299	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292011300	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292011301	Uncharacterized conserved protein [Function unknown]; Region: COG1565
240292011302	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
240292011303	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
240292011304	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292011305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292011306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011307	ATP binding site [chemical binding]; other site
240292011308	Mg2+ binding site [ion binding]; other site
240292011309	G-X-G motif; other site
240292011310	Predicted permeases [General function prediction only]; Region: COG0701
240292011311	Predicted membrane protein [Function unknown]; Region: COG3689
240292011312	Bacterial Ig-like domain; Region: Big_5; pfam13205
240292011313	Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150
240292011314	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
240292011315	ATP binding site [chemical binding]; other site
240292011316	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
240292011317	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
240292011318	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
240292011319	active site
240292011320	catalytic residues [active]
240292011321	metal binding site [ion binding]; metal-binding site
240292011322	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
240292011323	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292011324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292011325	catalytic loop [active]
240292011326	iron binding site [ion binding]; other site
240292011327	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
240292011328	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
240292011329	ThiS interaction site; other site
240292011330	putative active site [active]
240292011331	tetramer interface [polypeptide binding]; other site
240292011332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011333	binding surface
240292011334	TPR motif; other site
240292011335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011337	binding surface
240292011338	TPR motif; other site
240292011339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011340	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292011341	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
240292011342	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
240292011343	homooctamer interface [polypeptide binding]; other site
240292011344	active site
240292011345	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292011346	dimerization interface [polypeptide binding]; other site
240292011347	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292011348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292011349	putative active site [active]
240292011350	heme pocket [chemical binding]; other site
240292011351	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292011352	dimer interface [polypeptide binding]; other site
240292011353	phosphorylation site [posttranslational modification]
240292011354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011355	ATP binding site [chemical binding]; other site
240292011356	Mg2+ binding site [ion binding]; other site
240292011357	G-X-G motif; other site
240292011358	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
240292011359	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
240292011360	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
240292011361	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
240292011362	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292011363	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292011364	NAD(P) binding site [chemical binding]; other site
240292011365	active site
240292011366	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
240292011367	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
240292011368	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292011369	active site
240292011370	motif I; other site
240292011371	motif II; other site
240292011372	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
240292011373	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292011374	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
240292011375	phosphate binding site [ion binding]; other site
240292011376	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292011377	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292011378	metal binding site [ion binding]; metal-binding site
240292011379	active site
240292011380	I-site; other site
240292011381	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292011382	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
240292011383	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
240292011384	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
240292011385	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292011386	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
240292011387	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
240292011388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292011389	non-specific DNA binding site [nucleotide binding]; other site
240292011390	salt bridge; other site
240292011391	sequence-specific DNA binding site [nucleotide binding]; other site
240292011392	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292011393	NACHT domain; Region: NACHT; pfam05729
240292011394	Caspase domain; Region: Peptidase_C14; pfam00656
240292011395	Part of AAA domain; Region: AAA_19; pfam13245
240292011396	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
240292011397	AAA domain; Region: AAA_12; pfam13087
240292011398	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
240292011399	putative active site [active]
240292011400	catalytic site [active]
240292011401	Uncharacterized conserved protein [Function unknown]; Region: COG1262
240292011402	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240292011403	Protein of unknown function (DUF433); Region: DUF433; cl01030
240292011404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
240292011405	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
240292011406	DNA gyrase subunit A; Validated; Region: PRK05560
240292011407	DEAD-like helicases superfamily; Region: DEXDc; smart00487
240292011408	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
240292011409	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292011410	ATP binding site [chemical binding]; other site
240292011411	putative Mg++ binding site [ion binding]; other site
240292011412	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292011413	ATP-binding site [chemical binding]; other site
240292011414	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
240292011415	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
240292011416	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
240292011417	putative active site [active]
240292011418	putative NTP binding site [chemical binding]; other site
240292011419	putative nucleic acid binding site [nucleotide binding]; other site
240292011420	Divergent AAA domain; Region: AAA_4; pfam04326
240292011421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011422	TPR repeat; Region: TPR_11; pfam13414
240292011423	binding surface
240292011424	TPR motif; other site
240292011425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011426	binding surface
240292011427	TPR motif; other site
240292011428	TPR repeat; Region: TPR_11; pfam13414
240292011429	TIGR04255 family protein; Region: sporadTIGR04255
240292011430	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292011431	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292011432	active site
240292011433	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
240292011434	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011435	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011436	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011437	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011438	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292011439	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011440	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011441	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011442	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011443	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
240292011444	Cadherin repeat-like domain; Region: CA_like; cl15786
240292011445	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
240292011446	Ca2+ binding site [ion binding]; other site
240292011447	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292011448	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
240292011449	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
240292011450	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292011451	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
240292011452	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
240292011453	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292011454	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
240292011455	oligomeric interface; other site
240292011456	putative active site [active]
240292011457	homodimer interface [polypeptide binding]; other site
240292011458	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
240292011459	HsdM N-terminal domain; Region: HsdM_N; pfam12161
240292011460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292011461	S-adenosylmethionine binding site [chemical binding]; other site
240292011462	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
240292011463	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
240292011464	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
240292011465	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292011466	ATP binding site [chemical binding]; other site
240292011467	putative Mg++ binding site [ion binding]; other site
240292011468	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
240292011469	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
240292011470	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292011471	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292011472	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292011473	structural tetrad; other site
240292011474	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292011475	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292011476	structural tetrad; other site
240292011477	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
240292011478	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
240292011479	SNF2 Helicase protein; Region: DUF3670; pfam12419
240292011480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292011481	ATP binding site [chemical binding]; other site
240292011482	putative Mg++ binding site [ion binding]; other site
240292011483	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292011484	nucleotide binding region [chemical binding]; other site
240292011485	ATP-binding site [chemical binding]; other site
240292011486	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240292011487	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
240292011488	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
240292011489	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
240292011490	RNase E interface [polypeptide binding]; other site
240292011491	trimer interface [polypeptide binding]; other site
240292011492	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
240292011493	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
240292011494	RNase E interface [polypeptide binding]; other site
240292011495	trimer interface [polypeptide binding]; other site
240292011496	active site
240292011497	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
240292011498	putative nucleic acid binding region [nucleotide binding]; other site
240292011499	G-X-X-G motif; other site
240292011500	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
240292011501	RNA binding site [nucleotide binding]; other site
240292011502	domain interface; other site
240292011503	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
240292011504	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
240292011505	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
240292011506	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
240292011507	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
240292011508	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292011509	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
240292011510	ligand binding site [chemical binding]; other site
240292011511	flexible hinge region; other site
240292011512	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240292011513	putative switch regulator; other site
240292011514	non-specific DNA interactions [nucleotide binding]; other site
240292011515	DNA binding site [nucleotide binding]
240292011516	sequence specific DNA binding site [nucleotide binding]; other site
240292011517	putative cAMP binding site [chemical binding]; other site
240292011518	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
240292011519	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
240292011520	NAD binding site [chemical binding]; other site
240292011521	homotetramer interface [polypeptide binding]; other site
240292011522	homodimer interface [polypeptide binding]; other site
240292011523	substrate binding site [chemical binding]; other site
240292011524	active site
240292011525	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
240292011526	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
240292011527	putative active site pocket [active]
240292011528	4-fold oligomerization interface [polypeptide binding]; other site
240292011529	metal binding residues [ion binding]; metal-binding site
240292011530	3-fold/trimer interface [polypeptide binding]; other site
240292011531	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292011532	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240292011533	Walker A/P-loop; other site
240292011534	ATP binding site [chemical binding]; other site
240292011535	Q-loop/lid; other site
240292011536	ABC transporter signature motif; other site
240292011537	Walker B; other site
240292011538	D-loop; other site
240292011539	H-loop/switch region; other site
240292011540	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
240292011541	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240292011542	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
240292011543	SLBB domain; Region: SLBB; pfam10531
240292011544	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240292011545	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
240292011546	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
240292011547	dihydropteroate synthase; Region: DHPS; TIGR01496
240292011548	substrate binding pocket [chemical binding]; other site
240292011549	dimer interface [polypeptide binding]; other site
240292011550	inhibitor binding site; inhibition site
240292011551	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
240292011552	triosephosphate isomerase; Provisional; Region: PRK14565
240292011553	substrate binding site [chemical binding]; other site
240292011554	dimer interface [polypeptide binding]; other site
240292011555	catalytic triad [active]
240292011556	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
240292011557	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
240292011558	G1 box; other site
240292011559	GTP/Mg2+ binding site [chemical binding]; other site
240292011560	Switch I region; other site
240292011561	G2 box; other site
240292011562	Switch II region; other site
240292011563	G3 box; other site
240292011564	G4 box; other site
240292011565	G5 box; other site
240292011566	Domain of unknown function (DUF697); Region: DUF697; pfam05128
240292011567	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292011568	putative active site [active]
240292011569	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
240292011570	elongation factor G; Reviewed; Region: PRK12740
240292011571	G1 box; other site
240292011572	putative GEF interaction site [polypeptide binding]; other site
240292011573	GTP/Mg2+ binding site [chemical binding]; other site
240292011574	Switch I region; other site
240292011575	G2 box; other site
240292011576	G3 box; other site
240292011577	Switch II region; other site
240292011578	G4 box; other site
240292011579	G5 box; other site
240292011580	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
240292011581	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
240292011582	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
240292011583	TPR repeat; Region: TPR_11; pfam13414
240292011584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011585	binding surface
240292011586	TPR motif; other site
240292011587	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011588	binding surface
240292011589	TPR repeat; Region: TPR_11; pfam13414
240292011590	TPR motif; other site
240292011591	TPR repeat; Region: TPR_11; pfam13414
240292011592	Predicted membrane protein [Function unknown]; Region: COG3431
240292011593	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
240292011594	dimer interface [polypeptide binding]; other site
240292011595	active site
240292011596	Schiff base residues; other site
240292011597	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
240292011598	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
240292011599	G1 box; other site
240292011600	putative GEF interaction site [polypeptide binding]; other site
240292011601	GTP/Mg2+ binding site [chemical binding]; other site
240292011602	Switch I region; other site
240292011603	G2 box; other site
240292011604	G3 box; other site
240292011605	Switch II region; other site
240292011606	G4 box; other site
240292011607	G5 box; other site
240292011608	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
240292011609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292011610	binding surface
240292011611	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292011612	TPR motif; other site
240292011613	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
240292011614	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292011615	RNA recognition motif; Region: RRM; smart00360
240292011616	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
240292011617	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
240292011618	putative ADP-binding pocket [chemical binding]; other site
240292011619	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
240292011620	Domain of unknown function (DUF814); Region: DUF814; pfam05670
240292011621	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
240292011622	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
240292011623	Peptidase family M48; Region: Peptidase_M48; pfam01435
240292011624	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
240292011625	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292011626	active site
240292011627	metal binding site [ion binding]; metal-binding site
240292011628	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
240292011629	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292011630	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292011631	active site
240292011632	ATP binding site [chemical binding]; other site
240292011633	substrate binding site [chemical binding]; other site
240292011634	activation loop (A-loop); other site
240292011635	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292011636	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292011637	active site
240292011638	ATP binding site [chemical binding]; other site
240292011639	substrate binding site [chemical binding]; other site
240292011640	activation loop (A-loop); other site
240292011641	Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489
240292011642	magnesium chelatase subunit H; Provisional; Region: PRK12493
240292011643	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
240292011644	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
240292011645	XisH protein; Region: XisH; pfam08814
240292011646	XisI protein; Region: XisI; pfam08869
240292011647	AIPR protein; Region: AIPR; pfam10592
240292011648	XisH protein; Region: XisH; pfam08814
240292011649	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292011650	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292011651	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292011652	XisH protein; Region: XisH; pfam08814
240292011653	XisI protein; Region: XisI; pfam08869
240292011654	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
240292011655	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
240292011656	putative active site [active]
240292011657	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292011658	putative active site [active]
240292011659	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
240292011660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292011661	Coenzyme A binding pocket [chemical binding]; other site
240292011662	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
240292011663	ATP adenylyltransferase; Region: ATP_transf; pfam09830
240292011664	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
240292011665	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240292011666	Active Sites [active]
240292011667	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
240292011668	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
240292011669	active site
240292011670	metal binding site [ion binding]; metal-binding site
240292011671	DNA binding site [nucleotide binding]
240292011672	PUCC protein; Region: PUCC; pfam03209
240292011673	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
240292011674	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
240292011675	active site
240292011676	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
240292011677	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292011678	putative NAD(P) binding site [chemical binding]; other site
240292011679	catalytic Zn binding site [ion binding]; other site
240292011680	structural Zn binding site [ion binding]; other site
240292011681	tropinone reductase; Provisional; Region: PRK09242
240292011682	tropinone reductase-I and II (TR-1, and TR-II)-like, classical (c) SDRs; Region: TR_SDR_c; cd05329
240292011683	NADP binding site [chemical binding]; other site
240292011684	homodimer interface [polypeptide binding]; other site
240292011685	substrate binding site [chemical binding]; other site
240292011686	active site
240292011687	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
240292011688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
240292011689	substrate binding site [chemical binding]; other site
240292011690	oxyanion hole (OAH) forming residues; other site
240292011691	trimer interface [polypeptide binding]; other site
240292011692	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292011693	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292011694	ligand binding site [chemical binding]; other site
240292011695	flexible hinge region; other site
240292011696	putative switch regulator; other site
240292011697	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
240292011698	non-specific DNA interactions [nucleotide binding]; other site
240292011699	DNA binding site [nucleotide binding]
240292011700	sequence specific DNA binding site [nucleotide binding]; other site
240292011701	putative cAMP binding site [chemical binding]; other site
240292011702	chlorophyll synthase, ChlG; Region: ChlG; TIGR02056
240292011703	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292011704	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
240292011705	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292011706	P loop; other site
240292011707	Nucleotide binding site [chemical binding]; other site
240292011708	DTAP/Switch II; other site
240292011709	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
240292011710	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292011711	putative active site [active]
240292011712	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
240292011713	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
240292011714	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
240292011715	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
240292011716	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
240292011717	Walker A/P-loop; other site
240292011718	ATP binding site [chemical binding]; other site
240292011719	Q-loop/lid; other site
240292011720	ABC transporter signature motif; other site
240292011721	Walker B; other site
240292011722	D-loop; other site
240292011723	H-loop/switch region; other site
240292011724	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292011725	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
240292011726	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292011727	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
240292011728	Probable Catalytic site; other site
240292011729	metal-binding site
240292011730	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292011731	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292011732	GtrA-like protein; Region: GtrA; pfam04138
240292011733	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
240292011734	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
240292011735	Ligand binding site; other site
240292011736	Putative Catalytic site; other site
240292011737	DXD motif; other site
240292011738	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
240292011739	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292011740	NAD binding site [chemical binding]; other site
240292011741	homotetramer interface [polypeptide binding]; other site
240292011742	homodimer interface [polypeptide binding]; other site
240292011743	active site
240292011744	substrate binding site [chemical binding]; other site
240292011745	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
240292011746	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292011747	NAD binding site [chemical binding]; other site
240292011748	homotetramer interface [polypeptide binding]; other site
240292011749	homodimer interface [polypeptide binding]; other site
240292011750	active site
240292011751	substrate binding site [chemical binding]; other site
240292011752	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
240292011753	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
240292011754	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
240292011755	NADP binding site [chemical binding]; other site
240292011756	active site
240292011757	putative substrate binding site [chemical binding]; other site
240292011758	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
240292011759	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
240292011760	substrate binding site; other site
240292011761	metal-binding site
240292011762	Oligomer interface; other site
240292011763	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
240292011764	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292011765	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
240292011766	Probable Catalytic site; other site
240292011767	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
240292011768	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
240292011769	Probable Catalytic site; other site
240292011770	metal-binding site
240292011771	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292011772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292011773	S-adenosylmethionine binding site [chemical binding]; other site
240292011774	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292011775	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
240292011776	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
240292011777	Part of AAA domain; Region: AAA_19; pfam13245
240292011778	Family description; Region: UvrD_C_2; pfam13538
240292011779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292011780	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292011781	dimerization interface [polypeptide binding]; other site
240292011782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292011783	dimer interface [polypeptide binding]; other site
240292011784	phosphorylation site [posttranslational modification]
240292011785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011786	ATP binding site [chemical binding]; other site
240292011787	Mg2+ binding site [ion binding]; other site
240292011788	G-X-G motif; other site
240292011789	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
240292011790	S-layer homology domain; Region: SLH; pfam00395
240292011791	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292011792	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292011793	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
240292011794	ligand binding site [chemical binding]; other site
240292011795	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
240292011796	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
240292011797	PhoU domain; Region: PhoU; pfam01895
240292011798	PhoU domain; Region: PhoU; pfam01895
240292011799	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292011800	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292011801	dimer interface [polypeptide binding]; other site
240292011802	phosphorylation site [posttranslational modification]
240292011803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292011804	ATP binding site [chemical binding]; other site
240292011805	Mg2+ binding site [ion binding]; other site
240292011806	G-X-G motif; other site
240292011807	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292011808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292011809	active site
240292011810	phosphorylation site [posttranslational modification]
240292011811	intermolecular recognition site; other site
240292011812	dimerization interface [polypeptide binding]; other site
240292011813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292011814	DNA binding site [nucleotide binding]
240292011815	MAEBL; Provisional; Region: PTZ00121
240292011816	phosphodiesterase; Provisional; Region: PRK12704
240292011817	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
240292011818	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
240292011819	catalytic residues [active]
240292011820	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
240292011821	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
240292011822	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
240292011823	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
240292011824	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
240292011825	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
240292011826	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
240292011827	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
240292011828	cytochrome b subunit interaction site [polypeptide binding]; other site
240292011829	[2Fe-2S] cluster binding site [ion binding]; other site
240292011830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
240292011831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292011832	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
240292011833	ABC1 family; Region: ABC1; cl17513
240292011834	Protein phosphatase 2C; Region: PP2C; pfam00481
240292011835	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240292011836	active site
240292011837	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
240292011838	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292011839	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292011840	active site
240292011841	ATP binding site [chemical binding]; other site
240292011842	substrate binding site [chemical binding]; other site
240292011843	activation loop (A-loop); other site
240292011844	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
240292011845	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292011846	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
240292011847	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
240292011848	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
240292011849	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
240292011850	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
240292011851	MgtC family; Region: MgtC; pfam02308
240292011852	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
240292011853	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
240292011854	Walker A/P-loop; other site
240292011855	ATP binding site [chemical binding]; other site
240292011856	Q-loop/lid; other site
240292011857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292011858	ABC transporter signature motif; other site
240292011859	Walker B; other site
240292011860	D-loop; other site
240292011861	H-loop/switch region; other site
240292011862	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292011863	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
240292011864	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292011865	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292011866	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292011867	motif II; other site
240292011868	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292011869	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240292011870	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
240292011871	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
240292011872	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
240292011873	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
240292011874	NlpC/P60 family; Region: NLPC_P60; pfam00877
240292011875	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
240292011876	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
240292011877	Ligand binding site; other site
240292011878	Putative Catalytic site; other site
240292011879	DXD motif; other site
240292011880	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292011881	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292011882	putative substrate translocation pore; other site
240292011883	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
240292011884	trimer interface [polypeptide binding]; other site
240292011885	dimer interface [polypeptide binding]; other site
240292011886	putative active site [active]
240292011887	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
240292011888	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
240292011889	Response regulator receiver domain; Region: Response_reg; pfam00072
240292011890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292011891	active site
240292011892	phosphorylation site [posttranslational modification]
240292011893	intermolecular recognition site; other site
240292011894	dimerization interface [polypeptide binding]; other site
240292011895	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
240292011896	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
240292011897	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
240292011898	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
240292011899	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292011900	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
240292011901	Predicted membrane protein [Function unknown]; Region: COG2323
240292011902	adenylosuccinate lyase; Provisional; Region: PRK07380
240292011903	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
240292011904	tetramer interface [polypeptide binding]; other site
240292011905	active site
240292011906	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
240292011907	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
240292011908	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
240292011909	putative ADP-binding pocket [chemical binding]; other site
240292011910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292011911	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292011912	Walker A motif; other site
240292011913	ATP binding site [chemical binding]; other site
240292011914	Walker B motif; other site
240292011915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292011916	binding surface
240292011917	TPR motif; other site
240292011918	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292011919	Transposase domain (DUF772); Region: DUF772; pfam05598
240292011920	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292011921	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
240292011922	hypothetical protein; Reviewed; Region: PRK09588
240292011923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292011924	S-adenosylmethionine binding site [chemical binding]; other site
240292011925	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
240292011926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292011927	motif II; other site
240292011928	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
240292011929	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
240292011930	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
240292011931	active site
240292011932	Substrate binding site; other site
240292011933	Mg++ binding site; other site
240292011934	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
240292011935	putative trimer interface [polypeptide binding]; other site
240292011936	putative CoA binding site [chemical binding]; other site
240292011937	arginine decarboxylase; Provisional; Region: PRK05354
240292011938	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
240292011939	dimer interface [polypeptide binding]; other site
240292011940	active site
240292011941	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240292011942	catalytic residues [active]
240292011943	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
240292011944	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
240292011945	active site
240292011946	multimer interface [polypeptide binding]; other site
240292011947	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
240292011948	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
240292011949	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292011950	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292011951	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292011952	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292011953	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292011954	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292011955	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
240292011956	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
240292011957	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
240292011958	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
240292011959	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
240292011960	ligand binding site [chemical binding]; other site
240292011961	homodimer interface [polypeptide binding]; other site
240292011962	NAD(P) binding site [chemical binding]; other site
240292011963	trimer interface B [polypeptide binding]; other site
240292011964	trimer interface A [polypeptide binding]; other site
240292011965	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
240292011966	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
240292011967	ribonuclease P; Reviewed; Region: rnpA; PRK03031
240292011968	Bacterial PH domain; Region: DUF304; pfam03703
240292011969	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
240292011970	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
240292011971	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
240292011972	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
240292011973	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
240292011974	G-X-X-G motif; other site
240292011975	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
240292011976	RxxxH motif; other site
240292011977	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
240292011978	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
240292011979	Peptidase family M50; Region: Peptidase_M50; pfam02163
240292011980	active site
240292011981	putative substrate binding region [chemical binding]; other site
240292011982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292011983	carboxyl-terminal processing protease; Provisional; Region: PLN00049
240292011984	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240292011985	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240292011986	protein binding site [polypeptide binding]; other site
240292011987	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
240292011988	Catalytic dyad [active]
240292011989	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
240292011990	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
240292011991	Qi binding site; other site
240292011992	intrachain domain interface; other site
240292011993	interchain domain interface [polypeptide binding]; other site
240292011994	heme bH binding site [chemical binding]; other site
240292011995	heme bL binding site [chemical binding]; other site
240292011996	Qo binding site; other site
240292011997	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
240292011998	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
240292011999	interchain domain interface [polypeptide binding]; other site
240292012000	intrachain domain interface; other site
240292012001	Qi binding site; other site
240292012002	Qo binding site; other site
240292012003	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
240292012004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012005	ATP binding site [chemical binding]; other site
240292012006	Mg2+ binding site [ion binding]; other site
240292012007	G-X-G motif; other site
240292012008	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
240292012009	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
240292012010	NADP-binding site; other site
240292012011	homotetramer interface [polypeptide binding]; other site
240292012012	substrate binding site [chemical binding]; other site
240292012013	homodimer interface [polypeptide binding]; other site
240292012014	active site
240292012015	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292012016	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292012017	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
240292012018	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
240292012019	23S rRNA binding site [nucleotide binding]; other site
240292012020	L21 binding site [polypeptide binding]; other site
240292012021	L13 binding site [polypeptide binding]; other site
240292012022	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292012023	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
240292012024	substrate binding pocket [chemical binding]; other site
240292012025	membrane-bound complex binding site; other site
240292012026	hinge residues; other site
240292012027	TPR repeat; Region: TPR_11; pfam13414
240292012028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012029	binding surface
240292012030	TPR motif; other site
240292012031	TPR repeat; Region: TPR_11; pfam13414
240292012032	Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733
240292012033	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
240292012034	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
240292012035	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
240292012036	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292012037	dimerization interface [polypeptide binding]; other site
240292012038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292012039	dimer interface [polypeptide binding]; other site
240292012040	phosphorylation site [posttranslational modification]
240292012041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012042	ATP binding site [chemical binding]; other site
240292012043	Mg2+ binding site [ion binding]; other site
240292012044	G-X-G motif; other site
240292012045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292012046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012047	active site
240292012048	phosphorylation site [posttranslational modification]
240292012049	intermolecular recognition site; other site
240292012050	dimerization interface [polypeptide binding]; other site
240292012051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292012052	DNA binding site [nucleotide binding]
240292012053	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
240292012054	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
240292012055	catalytic residue [active]
240292012056	putative FPP diphosphate  binding site; other site
240292012057	putative FPP binding hydrophobic cleft; other site
240292012058	dimer interface [polypeptide binding]; other site
240292012059	putative IPP diphosphate binding site; other site
240292012060	Predicted membrane protein [Function unknown]; Region: COG3918
240292012061	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292012062	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292012063	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292012064	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
240292012065	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
240292012066	NADP binding site [chemical binding]; other site
240292012067	homodimer interface [polypeptide binding]; other site
240292012068	active site
240292012069	substrate binding site [chemical binding]; other site
240292012070	mercuric reductase; Validated; Region: PRK06370
240292012071	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
240292012072	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292012073	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240292012074	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
240292012075	active site
240292012076	AAA ATPase domain; Region: AAA_16; pfam13191
240292012077	NACHT domain; Region: NACHT; pfam05729
240292012078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012079	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012080	TPR motif; other site
240292012081	binding surface
240292012082	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012083	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
240292012084	GIY-YIG motif/motif A; other site
240292012085	active site
240292012086	catalytic site [active]
240292012087	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
240292012088	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
240292012089	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
240292012090	PAS fold; Region: PAS_3; pfam08447
240292012091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012092	putative active site [active]
240292012093	heme pocket [chemical binding]; other site
240292012094	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292012095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012096	putative active site [active]
240292012097	heme pocket [chemical binding]; other site
240292012098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012099	putative active site [active]
240292012100	heme pocket [chemical binding]; other site
240292012101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292012103	dimer interface [polypeptide binding]; other site
240292012104	phosphorylation site [posttranslational modification]
240292012105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012106	ATP binding site [chemical binding]; other site
240292012107	Mg2+ binding site [ion binding]; other site
240292012108	G-X-G motif; other site
240292012109	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292012110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012111	active site
240292012112	phosphorylation site [posttranslational modification]
240292012113	intermolecular recognition site; other site
240292012114	dimerization interface [polypeptide binding]; other site
240292012115	oxo-acid-lyase/anthranilate synthase; Region: PLN02889
240292012116	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
240292012117	glutamine binding [chemical binding]; other site
240292012118	catalytic triad [active]
240292012119	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
240292012120	chorismate binding enzyme; Region: Chorismate_bind; cl10555
240292012121	DNA polymerase III subunit delta; Validated; Region: PRK07452
240292012122	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
240292012123	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
240292012124	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292012125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292012126	DNA binding residues [nucleotide binding]
240292012127	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
240292012128	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292012129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012130	binding surface
240292012131	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292012132	TPR motif; other site
240292012133	TPR repeat; Region: TPR_11; pfam13414
240292012134	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
240292012135	active site
240292012136	SAM binding site [chemical binding]; other site
240292012137	homodimer interface [polypeptide binding]; other site
240292012138	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
240292012139	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
240292012140	active site
240292012141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
240292012142	septum formation inhibitor; Reviewed; Region: minC; PRK00513
240292012143	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
240292012144	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
240292012145	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
240292012146	Switch I; other site
240292012147	Switch II; other site
240292012148	cell division topological specificity factor MinE; Provisional; Region: PRK13988
240292012149	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
240292012150	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
240292012151	putative active site [active]
240292012152	substrate binding site [chemical binding]; other site
240292012153	putative cosubstrate binding site; other site
240292012154	catalytic site [active]
240292012155	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
240292012156	substrate binding site [chemical binding]; other site
240292012157	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012158	binding surface
240292012159	TPR motif; other site
240292012160	TPR repeat; Region: TPR_11; pfam13414
240292012161	TPR repeat; Region: TPR_11; pfam13414
240292012162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012163	binding surface
240292012164	TPR motif; other site
240292012165	TPR repeat; Region: TPR_11; pfam13414
240292012166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012167	binding surface
240292012168	TPR motif; other site
240292012169	TPR repeat; Region: TPR_11; pfam13414
240292012170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012171	binding surface
240292012172	TPR motif; other site
240292012173	TPR repeat; Region: TPR_11; pfam13414
240292012174	photosystem I subunit VII; Region: psaC; CHL00065
240292012175	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292012176	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
240292012177	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
240292012178	glutaminase active site [active]
240292012179	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
240292012180	dimer interface [polypeptide binding]; other site
240292012181	active site
240292012182	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
240292012183	dimer interface [polypeptide binding]; other site
240292012184	active site
240292012185	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292012186	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292012187	Integrase core domain; Region: rve; pfam00665
240292012188	AAA domain; Region: AAA_22; pfam13401
240292012189	AAA ATPase domain; Region: AAA_16; pfam13191
240292012190	Bacterial TniB protein; Region: TniB; pfam05621
240292012191	TniQ; Region: TniQ; pfam06527
240292012192	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703
240292012193	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09713
240292012194	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cd09714
240292012195	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
240292012196	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688
240292012197	TniQ; Region: TniQ; pfam06527
240292012198	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
240292012199	HsdM N-terminal domain; Region: HsdM_N; pfam12161
240292012200	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
240292012201	Methyltransferase domain; Region: Methyltransf_26; pfam13659
240292012202	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
240292012203	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292012204	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240292012205	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
240292012206	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
240292012207	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
240292012208	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
240292012209	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
240292012210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292012211	ATP binding site [chemical binding]; other site
240292012212	putative Mg++ binding site [ion binding]; other site
240292012213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292012214	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240292012215	Walker A motif; other site
240292012216	ATP binding site [chemical binding]; other site
240292012217	Walker B motif; other site
240292012218	arginine finger; other site
240292012219	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
240292012220	active site
240292012221	catalytic triad [active]
240292012222	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
240292012223	TPR repeat; Region: TPR_11; pfam13414
240292012224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012225	binding surface
240292012226	TPR motif; other site
240292012227	TPR repeat; Region: TPR_11; pfam13414
240292012228	TPR repeat; Region: TPR_11; pfam13414
240292012229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012230	binding surface
240292012231	TPR motif; other site
240292012232	TPR repeat; Region: TPR_11; pfam13414
240292012233	TPR repeat; Region: TPR_11; pfam13414
240292012234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012235	binding surface
240292012236	TPR motif; other site
240292012237	CHAT domain; Region: CHAT; pfam12770
240292012238	NACHT domain; Region: NACHT; pfam05729
240292012239	HEAT-like repeat; Region: HEAT_EZ; pfam13513
240292012240	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
240292012241	HEAT-like repeat; Region: HEAT_EZ; pfam13513
240292012242	protein binding surface [polypeptide binding]; other site
240292012243	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
240292012244	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292012245	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292012246	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
240292012247	protein binding surface [polypeptide binding]; other site
240292012248	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292012249	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292012250	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
240292012251	protein binding surface [polypeptide binding]; other site
240292012252	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292012253	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
240292012254	G1 box; other site
240292012255	GTP/Mg2+ binding site [chemical binding]; other site
240292012256	G2 box; other site
240292012257	Switch I region; other site
240292012258	G3 box; other site
240292012259	Switch II region; other site
240292012260	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
240292012261	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
240292012262	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
240292012263	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
240292012264	active site
240292012265	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
240292012266	dimer interface [polypeptide binding]; other site
240292012267	ADP-ribose binding site [chemical binding]; other site
240292012268	active site
240292012269	nudix motif; other site
240292012270	metal binding site [ion binding]; metal-binding site
240292012271	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
240292012272	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292012273	Coenzyme A binding pocket [chemical binding]; other site
240292012274	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
240292012275	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
240292012276	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
240292012277	dimerization interface [polypeptide binding]; other site
240292012278	active site
240292012279	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
240292012280	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240292012281	enolase; Provisional; Region: eno; PRK00077
240292012282	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
240292012283	dimer interface [polypeptide binding]; other site
240292012284	metal binding site [ion binding]; metal-binding site
240292012285	substrate binding pocket [chemical binding]; other site
240292012286	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
240292012287	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
240292012288	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
240292012289	dimer interface [polypeptide binding]; other site
240292012290	substrate binding site [chemical binding]; other site
240292012291	ATP binding site [chemical binding]; other site
240292012292	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
240292012293	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
240292012294	active site
240292012295	catalytic triad [active]
240292012296	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292012297	CHAT domain; Region: CHAT; pfam12770
240292012298	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240292012299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292012301	dimer interface [polypeptide binding]; other site
240292012302	phosphorylation site [posttranslational modification]
240292012303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012304	ATP binding site [chemical binding]; other site
240292012305	Mg2+ binding site [ion binding]; other site
240292012306	G-X-G motif; other site
240292012307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
240292012308	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292012309	HEAT repeats; Region: HEAT_2; pfam13646
240292012310	HEAT repeats; Region: HEAT_2; pfam13646
240292012311	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
240292012312	EamA-like transporter family; Region: EamA; pfam00892
240292012313	EamA-like transporter family; Region: EamA; pfam00892
240292012314	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
240292012315	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
240292012316	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
240292012317	UbiA prenyltransferase family; Region: UbiA; pfam01040
240292012318	acetolactate synthase; Reviewed; Region: PRK08322
240292012319	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
240292012320	PYR/PP interface [polypeptide binding]; other site
240292012321	dimer interface [polypeptide binding]; other site
240292012322	TPP binding site [chemical binding]; other site
240292012323	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240292012324	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
240292012325	TPP-binding site [chemical binding]; other site
240292012326	dimer interface [polypeptide binding]; other site
240292012327	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
240292012328	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
240292012329	NAD(P) binding site [chemical binding]; other site
240292012330	catalytic residues [active]
240292012331	Protein kinase domain; Region: Pkinase; pfam00069
240292012332	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292012333	active site
240292012334	ATP binding site [chemical binding]; other site
240292012335	substrate binding site [chemical binding]; other site
240292012336	activation loop (A-loop); other site
240292012337	AAA ATPase domain; Region: AAA_16; pfam13191
240292012338	Predicted ATPase [General function prediction only]; Region: COG3899
240292012339	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012340	GAF domain; Region: GAF; pfam01590
240292012341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012343	ATP binding site [chemical binding]; other site
240292012344	Mg2+ binding site [ion binding]; other site
240292012345	G-X-G motif; other site
240292012346	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292012347	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292012348	ligand binding site [chemical binding]; other site
240292012349	flexible hinge region; other site
240292012350	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
240292012351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240292012352	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
240292012353	4Fe-4S binding domain; Region: Fer4_5; pfam12801
240292012354	4Fe-4S binding domain; Region: Fer4_5; pfam12801
240292012355	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
240292012356	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
240292012357	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
240292012358	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
240292012359	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
240292012360	PAS domain S-box; Region: sensory_box; TIGR00229
240292012361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012362	putative active site [active]
240292012363	heme pocket [chemical binding]; other site
240292012364	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012366	ATP binding site [chemical binding]; other site
240292012367	Mg2+ binding site [ion binding]; other site
240292012368	G-X-G motif; other site
240292012369	PAS fold; Region: PAS_4; pfam08448
240292012370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012371	putative active site [active]
240292012372	heme pocket [chemical binding]; other site
240292012373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012375	ATP binding site [chemical binding]; other site
240292012376	Mg2+ binding site [ion binding]; other site
240292012377	G-X-G motif; other site
240292012378	probable methyltransferase domain, EasF family; Region: methyl_EasF; TIGR03439
240292012379	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
240292012380	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
240292012381	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292012382	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240292012383	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
240292012384	Ligand Binding Site [chemical binding]; other site
240292012385	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
240292012386	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
240292012387	tetramerization interface [polypeptide binding]; other site
240292012388	active site
240292012389	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
240292012390	dimer interface [polypeptide binding]; other site
240292012391	substrate binding site [chemical binding]; other site
240292012392	metal binding sites [ion binding]; metal-binding site
240292012393	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
240292012394	protein I interface; other site
240292012395	D2 interface; other site
240292012396	protein T interface; other site
240292012397	chlorophyll binding site; other site
240292012398	beta carotene binding site; other site
240292012399	pheophytin binding site; other site
240292012400	manganese-stabilizing polypeptide interface; other site
240292012401	CP43 interface; other site
240292012402	protein L interface; other site
240292012403	oxygen evolving complex binding site; other site
240292012404	bromide binding site; other site
240292012405	quinone binding site; other site
240292012406	Fe binding site [ion binding]; other site
240292012407	core light harvesting interface; other site
240292012408	cytochrome b559 alpha subunit interface; other site
240292012409	cytochrome c-550 interface; other site
240292012410	protein J interface; other site
240292012411	light-harvesting-like protein 3; Provisional; Region: PLN00014
240292012412	Uncharacterized conserved protein [Function unknown]; Region: COG2006
240292012413	Domain of unknown function (DUF362); Region: DUF362; pfam04015
240292012414	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
240292012415	Aspartase; Region: Aspartase; cd01357
240292012416	active sites [active]
240292012417	tetramer interface [polypeptide binding]; other site
240292012418	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292012419	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
240292012420	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292012421	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292012422	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
240292012423	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292012424	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292012425	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
240292012426	active site
240292012427	putative homodimer interface [polypeptide binding]; other site
240292012428	SAM binding site [chemical binding]; other site
240292012429	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
240292012430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292012431	S-adenosylmethionine binding site [chemical binding]; other site
240292012432	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
240292012433	metal-binding site [ion binding]
240292012434	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
240292012435	arginine-tRNA ligase; Region: PLN02286
240292012436	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
240292012437	active site
240292012438	HIGH motif; other site
240292012439	KMSK motif region; other site
240292012440	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
240292012441	tRNA binding surface [nucleotide binding]; other site
240292012442	anticodon binding site; other site
240292012443	Predicted ATPase [General function prediction only]; Region: COG4637
240292012444	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292012445	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292012446	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
240292012447	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292012448	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292012449	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292012450	motif II; other site
240292012451	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292012452	AAA ATPase domain; Region: AAA_16; pfam13191
240292012453	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
240292012454	dimerization interface [polypeptide binding]; other site
240292012455	putative active cleft [active]
240292012456	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292012457	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292012458	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
240292012459	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240292012460	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292012461	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292012462	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292012463	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292012464	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292012465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292012466	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240292012467	Subunit I/III interface [polypeptide binding]; other site
240292012468	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240292012469	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
240292012470	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292012471	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
240292012472	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240292012473	Predicted membrane protein [Function unknown]; Region: COG4244
240292012474	Predicted membrane protein [Function unknown]; Region: COG4244
240292012475	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
240292012476	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
240292012477	Predicted permeases [General function prediction only]; Region: COG0679
240292012478	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
240292012479	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292012480	active site
240292012481	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
240292012482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292012483	putative substrate translocation pore; other site
240292012484	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292012485	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292012486	active site
240292012487	ATP binding site [chemical binding]; other site
240292012488	substrate binding site [chemical binding]; other site
240292012489	activation loop (A-loop); other site
240292012490	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
240292012491	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292012492	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292012493	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292012494	DevC protein; Region: devC; TIGR01185
240292012495	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292012496	FtsX-like permease family; Region: FtsX; pfam02687
240292012497	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292012498	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292012499	Walker A/P-loop; other site
240292012500	ATP binding site [chemical binding]; other site
240292012501	Q-loop/lid; other site
240292012502	ABC transporter signature motif; other site
240292012503	Walker B; other site
240292012504	D-loop; other site
240292012505	H-loop/switch region; other site
240292012506	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
240292012507	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292012508	active site
240292012509	motif I; other site
240292012510	motif II; other site
240292012511	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
240292012512	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240292012513	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240292012514	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
240292012515	Protein of unknown function DUF262; Region: DUF262; pfam03235
240292012516	Uncharacterized conserved protein [Function unknown]; Region: COG1479
240292012517	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240292012518	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292012519	mechanosensitive channel MscS; Provisional; Region: PRK10334
240292012520	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292012521	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292012522	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292012523	active site
240292012524	ATP binding site [chemical binding]; other site
240292012525	substrate binding site [chemical binding]; other site
240292012526	activation loop (A-loop); other site
240292012527	AAA ATPase domain; Region: AAA_16; pfam13191
240292012528	Predicted ATPase [General function prediction only]; Region: COG3899
240292012529	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012530	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292012531	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012532	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292012533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012535	ATP binding site [chemical binding]; other site
240292012536	Mg2+ binding site [ion binding]; other site
240292012537	G-X-G motif; other site
240292012538	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240292012539	O-Antigen ligase; Region: Wzy_C; pfam04932
240292012540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
240292012541	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
240292012542	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240292012543	Acyl transferase domain; Region: Acyl_transf_1; cl08282
240292012544	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
240292012545	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292012546	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292012547	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
240292012548	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
240292012549	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
240292012550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292012551	Walker A motif; other site
240292012552	ATP binding site [chemical binding]; other site
240292012553	Walker B motif; other site
240292012554	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
240292012555	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
240292012556	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
240292012557	oligomer interface [polypeptide binding]; other site
240292012558	active site residues [active]
240292012559	trigger factor; Provisional; Region: tig; PRK01490
240292012560	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
240292012561	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
240292012562	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
240292012563	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240292012564	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
240292012565	dihydrodipicolinate synthase; Region: dapA; TIGR00674
240292012566	dimer interface [polypeptide binding]; other site
240292012567	active site
240292012568	catalytic residue [active]
240292012569	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
240292012570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
240292012571	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
240292012572	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
240292012573	transmembrane helices; other site
240292012574	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
240292012575	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292012576	Caspase domain; Region: Peptidase_C14; pfam00656
240292012577	ribosomal protein L32; Validated; Region: rpl32; CHL00152
240292012578	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
240292012579	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
240292012580	Moco binding site; other site
240292012581	metal coordination site [ion binding]; other site
240292012582	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
240292012583	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
240292012584	NAD(P) binding site [chemical binding]; other site
240292012585	catalytic residues [active]
240292012586	Response regulator receiver domain; Region: Response_reg; pfam00072
240292012587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012588	active site
240292012589	phosphorylation site [posttranslational modification]
240292012590	intermolecular recognition site; other site
240292012591	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012592	dimerization interface [polypeptide binding]; other site
240292012593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292012594	dimer interface [polypeptide binding]; other site
240292012595	phosphorylation site [posttranslational modification]
240292012596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012597	ATP binding site [chemical binding]; other site
240292012598	Mg2+ binding site [ion binding]; other site
240292012599	G-X-G motif; other site
240292012600	urease subunit alpha; Reviewed; Region: ureC; PRK13207
240292012601	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
240292012602	subunit interactions [polypeptide binding]; other site
240292012603	active site
240292012604	flap region; other site
240292012605	GxxExxY protein; Region: GxxExxY; TIGR04256
240292012606	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
240292012607	gamma-beta subunit interface [polypeptide binding]; other site
240292012608	alpha-beta subunit interface [polypeptide binding]; other site
240292012609	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
240292012610	alpha-gamma subunit interface [polypeptide binding]; other site
240292012611	beta-gamma subunit interface [polypeptide binding]; other site
240292012612	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
240292012613	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
240292012614	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292012615	P-loop; other site
240292012616	Magnesium ion binding site [ion binding]; other site
240292012617	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
240292012618	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
240292012619	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
240292012620	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
240292012621	ring oligomerisation interface [polypeptide binding]; other site
240292012622	ATP/Mg binding site [chemical binding]; other site
240292012623	stacking interactions; other site
240292012624	hinge regions; other site
240292012625	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
240292012626	oligomerisation interface [polypeptide binding]; other site
240292012627	mobile loop; other site
240292012628	roof hairpin; other site
240292012629	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292012630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012631	active site
240292012632	phosphorylation site [posttranslational modification]
240292012633	intermolecular recognition site; other site
240292012634	dimerization interface [polypeptide binding]; other site
240292012635	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292012636	DNA binding residues [nucleotide binding]
240292012637	dimerization interface [polypeptide binding]; other site
240292012638	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
240292012639	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
240292012640	putative dimer interface [polypeptide binding]; other site
240292012641	putative anticodon binding site; other site
240292012642	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
240292012643	homodimer interface [polypeptide binding]; other site
240292012644	motif 1; other site
240292012645	motif 2; other site
240292012646	active site
240292012647	motif 3; other site
240292012648	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
240292012649	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
240292012650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
240292012651	ATP binding site [chemical binding]; other site
240292012652	Mg2+ binding site [ion binding]; other site
240292012653	G-X-G motif; other site
240292012654	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
240292012655	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
240292012656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292012657	S-adenosylmethionine binding site [chemical binding]; other site
240292012658	Phycobilisome protein; Region: Phycobilisome; cl08227
240292012659	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
240292012660	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
240292012661	dimerization interface [polypeptide binding]; other site
240292012662	ATP binding site [chemical binding]; other site
240292012663	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
240292012664	dimerization interface [polypeptide binding]; other site
240292012665	ATP binding site [chemical binding]; other site
240292012666	amidophosphoribosyltransferase; Provisional; Region: PRK07349
240292012667	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
240292012668	active site
240292012669	tetramer interface [polypeptide binding]; other site
240292012670	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292012671	active site
240292012672	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292012673	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292012674	Walker A/P-loop; other site
240292012675	ATP binding site [chemical binding]; other site
240292012676	Q-loop/lid; other site
240292012677	ABC transporter signature motif; other site
240292012678	Walker B; other site
240292012679	D-loop; other site
240292012680	H-loop/switch region; other site
240292012681	DevC protein; Region: devC; TIGR01185
240292012682	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292012683	FtsX-like permease family; Region: FtsX; pfam02687
240292012684	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292012685	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292012686	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292012687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292012688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292012689	aspartate kinase; Provisional; Region: PRK07431
240292012690	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
240292012691	putative nucleotide binding site [chemical binding]; other site
240292012692	putative catalytic residues [active]
240292012693	putative Mg ion binding site [ion binding]; other site
240292012694	putative aspartate binding site [chemical binding]; other site
240292012695	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
240292012696	putative allosteric regulatory site; other site
240292012697	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
240292012698	putative allosteric regulatory residue; other site
240292012699	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
240292012700	putative allosteric regulatory site; other site
240292012701	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
240292012702	putative allosteric regulatory residue; other site
240292012703	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
240292012704	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
240292012705	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
240292012706	Calx-beta domain; Region: Calx-beta; pfam03160
240292012707	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
240292012708	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
240292012709	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
240292012710	transketolase; Region: PLN02790
240292012711	TPP-binding site [chemical binding]; other site
240292012712	dimer interface [polypeptide binding]; other site
240292012713	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
240292012714	PYR/PP interface [polypeptide binding]; other site
240292012715	dimer interface [polypeptide binding]; other site
240292012716	TPP binding site [chemical binding]; other site
240292012717	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240292012718	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
240292012719	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
240292012720	dimer interface [polypeptide binding]; other site
240292012721	active site
240292012722	acyl carrier protein; Provisional; Region: acpP; PRK00982
240292012723	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
240292012724	Cysteine-rich domain; Region: CCG; pfam02754
240292012725	Cysteine-rich domain; Region: CCG; pfam02754
240292012726	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
240292012727	dihydroorotase; Provisional; Region: PRK07369
240292012728	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240292012729	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
240292012730	active site
240292012731	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
240292012732	catalytic core [active]
240292012733	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
240292012734	catalytic core [active]
240292012735	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
240292012736	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
240292012737	NADP binding site [chemical binding]; other site
240292012738	active site
240292012739	putative substrate binding site [chemical binding]; other site
240292012740	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292012741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292012742	dimer interface [polypeptide binding]; other site
240292012743	conserved gate region; other site
240292012744	putative PBP binding loops; other site
240292012745	ABC-ATPase subunit interface; other site
240292012746	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292012747	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
240292012748	Walker A/P-loop; other site
240292012749	ATP binding site [chemical binding]; other site
240292012750	Q-loop/lid; other site
240292012751	ABC transporter signature motif; other site
240292012752	Walker B; other site
240292012753	D-loop; other site
240292012754	H-loop/switch region; other site
240292012755	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292012756	NMT1-like family; Region: NMT1_2; pfam13379
240292012757	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292012758	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292012759	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292012760	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
240292012761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292012762	putative Mg++ binding site [ion binding]; other site
240292012763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292012764	nucleotide binding region [chemical binding]; other site
240292012765	ATP-binding site [chemical binding]; other site
240292012766	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
240292012767	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
240292012768	Walker A motif; other site
240292012769	ATP binding site [chemical binding]; other site
240292012770	Walker B motif; other site
240292012771	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
240292012772	tetramer interface [polypeptide binding]; other site
240292012773	dimer interface [polypeptide binding]; other site
240292012774	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
240292012775	Predicted membrane protein [Function unknown]; Region: COG4872
240292012776	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
240292012777	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
240292012778	Calcium binding; Region: Calci_bind_CcbP; pfam11535
240292012779	maltose O-acetyltransferase; Provisional; Region: PRK10092
240292012780	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
240292012781	active site
240292012782	substrate binding site [chemical binding]; other site
240292012783	trimer interface [polypeptide binding]; other site
240292012784	CoA binding site [chemical binding]; other site
240292012785	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292012786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012787	active site
240292012788	phosphorylation site [posttranslational modification]
240292012789	intermolecular recognition site; other site
240292012790	dimerization interface [polypeptide binding]; other site
240292012791	PAS fold; Region: PAS; pfam00989
240292012792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012793	putative active site [active]
240292012794	heme pocket [chemical binding]; other site
240292012795	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292012796	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292012797	metal binding site [ion binding]; metal-binding site
240292012798	active site
240292012799	I-site; other site
240292012800	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
240292012801	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292012802	catalytic residues [active]
240292012803	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292012804	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
240292012805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
240292012806	motif II; other site
240292012807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
240292012808	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
240292012809	amidase; Provisional; Region: PRK09201
240292012810	Amidase; Region: Amidase; cl11426
240292012811	Transposase domain (DUF772); Region: DUF772; pfam05598
240292012812	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292012813	methionine aminopeptidase; Provisional; Region: PRK12318
240292012814	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
240292012815	active site
240292012816	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
240292012817	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292012818	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292012819	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292012820	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292012821	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292012822	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292012823	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292012824	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240292012825	active site
240292012826	metal binding site [ion binding]; metal-binding site
240292012827	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
240292012828	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
240292012829	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
240292012830	trimer interface [polypeptide binding]; other site
240292012831	putative metal binding site [ion binding]; other site
240292012832	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
240292012833	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240292012834	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
240292012835	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
240292012836	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
240292012837	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
240292012838	Cell division protein FtsA; Region: FtsA; cl17206
240292012839	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
240292012840	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
240292012841	AMIN domain; Region: AMIN; pfam11741
240292012842	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
240292012843	Secretin and TonB N terminus short domain; Region: STN; pfam07660
240292012844	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
240292012845	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240292012846	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
240292012847	Phage-related protein [Function unknown]; Region: COG4679
240292012848	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292012849	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292012850	ligand binding site [chemical binding]; other site
240292012851	flexible hinge region; other site
240292012852	hypothetical protein; Provisional; Region: PRK02509
240292012853	Uncharacterized conserved protein [Function unknown]; Region: COG1615
240292012854	aspartate aminotransferase; Provisional; Region: PRK05957
240292012855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292012856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292012857	homodimer interface [polypeptide binding]; other site
240292012858	catalytic residue [active]
240292012859	Uncharacterized conserved protein [Function unknown]; Region: COG0432
240292012860	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
240292012861	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
240292012862	putative active site [active]
240292012863	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
240292012864	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
240292012865	tRNA; other site
240292012866	putative tRNA binding site [nucleotide binding]; other site
240292012867	putative NADP binding site [chemical binding]; other site
240292012868	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
240292012869	Helix-turn-helix domain; Region: HTH_17; cl17695
240292012870	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292012871	dimerization interface [polypeptide binding]; other site
240292012872	putative DNA binding site [nucleotide binding]; other site
240292012873	putative Zn2+ binding site [ion binding]; other site
240292012874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860
240292012875	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
240292012876	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
240292012877	Walker A/P-loop; other site
240292012878	ATP binding site [chemical binding]; other site
240292012879	Q-loop/lid; other site
240292012880	ABC transporter signature motif; other site
240292012881	Walker B; other site
240292012882	D-loop; other site
240292012883	H-loop/switch region; other site
240292012884	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
240292012885	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
240292012886	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
240292012887	TM-ABC transporter signature motif; other site
240292012888	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
240292012889	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
240292012890	active site
240292012891	dimer interface [polypeptide binding]; other site
240292012892	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
240292012893	dimer interface [polypeptide binding]; other site
240292012894	active site
240292012895	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
240292012896	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
240292012897	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
240292012898	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292012899	putative active site [active]
240292012900	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
240292012901	Low molecular weight phosphatase family; Region: LMWPc; cd00115
240292012902	active site
240292012903	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
240292012904	arsenical-resistance protein; Region: acr3; TIGR00832
240292012905	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
240292012906	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
240292012907	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
240292012908	PBP superfamily domain; Region: PBP_like_2; cl17296
240292012909	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
240292012910	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292012911	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
240292012912	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
240292012913	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
240292012914	active site
240292012915	HIGH motif; other site
240292012916	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
240292012917	KMSKS motif; other site
240292012918	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
240292012919	tRNA binding surface [nucleotide binding]; other site
240292012920	anticodon binding site; other site
240292012921	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292012922	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240292012923	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012924	GAF domain; Region: GAF_3; pfam13492
240292012925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292012926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292012927	ATP binding site [chemical binding]; other site
240292012928	Mg2+ binding site [ion binding]; other site
240292012929	G-X-G motif; other site
240292012930	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
240292012931	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292012932	anti sigma factor interaction site; other site
240292012933	regulatory phosphorylation site [posttranslational modification]; other site
240292012934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292012935	Response regulator receiver domain; Region: Response_reg; pfam00072
240292012936	active site
240292012937	phosphorylation site [posttranslational modification]
240292012938	intermolecular recognition site; other site
240292012939	dimerization interface [polypeptide binding]; other site
240292012940	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240292012941	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240292012942	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
240292012943	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
240292012944	N-terminal domain interface [polypeptide binding]; other site
240292012945	dimer interface [polypeptide binding]; other site
240292012946	substrate binding pocket (H-site) [chemical binding]; other site
240292012947	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
240292012948	Psb28 protein; Region: Psb28; pfam03912
240292012949	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012951	binding surface
240292012952	TPR motif; other site
240292012953	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012954	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012956	binding surface
240292012957	TPR motif; other site
240292012958	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292012960	binding surface
240292012961	TPR motif; other site
240292012962	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012963	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292012964	acetylornithine aminotransferase; Provisional; Region: PRK02627
240292012965	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292012966	inhibitor-cofactor binding pocket; inhibition site
240292012967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292012968	catalytic residue [active]
240292012969	Ion channel; Region: Ion_trans_2; pfam07885
240292012970	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292012971	TrkA-N domain; Region: TrkA_N; pfam02254
240292012972	TrkA-C domain; Region: TrkA_C; pfam02080
240292012973	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
240292012974	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
240292012975	RNA binding site [nucleotide binding]; other site
240292012976	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
240292012977	RNA binding site [nucleotide binding]; other site
240292012978	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
240292012979	RNA binding site [nucleotide binding]; other site
240292012980	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240292012981	Predicted transcriptional regulators [Transcription]; Region: COG1725
240292012982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240292012983	DNA-binding site [nucleotide binding]; DNA binding site
240292012984	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292012985	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012986	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292012987	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292012988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292012989	PAS domain; Region: PAS_9; pfam13426
240292012990	putative active site [active]
240292012991	heme pocket [chemical binding]; other site
240292012992	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240292012993	cyclase homology domain; Region: CHD; cd07302
240292012994	nucleotidyl binding site; other site
240292012995	metal binding site [ion binding]; metal-binding site
240292012996	dimer interface [polypeptide binding]; other site
240292012997	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292012998	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292012999	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292013000	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
240292013001	PhoD-like phosphatase; Region: PhoD; pfam09423
240292013002	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292013003	putative active site [active]
240292013004	putative metal binding site [ion binding]; other site
240292013005	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292013006	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
240292013007	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
240292013008	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292013009	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
240292013010	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
240292013011	putative active site [active]
240292013012	catalytic site [active]
240292013013	putative metal binding site [ion binding]; other site
240292013014	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292013015	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
240292013016	Helix-turn-helix domain; Region: HTH_25; pfam13413
240292013017	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
240292013018	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
240292013019	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
240292013020	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
240292013021	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
240292013022	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
240292013023	generic binding surface I; other site
240292013024	generic binding surface II; other site
240292013025	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
240292013026	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
240292013027	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
240292013028	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
240292013029	beta-phosphoglucomutase; Region: bPGM; TIGR01990
240292013030	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292013031	sucrose synthase; Region: sucr_synth; TIGR02470
240292013032	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
240292013033	putative ADP-binding pocket [chemical binding]; other site
240292013034	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
240292013035	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
240292013036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
240292013037	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
240292013038	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
240292013039	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
240292013040	ligand binding site [chemical binding]; other site
240292013041	NAD binding site [chemical binding]; other site
240292013042	dimerization interface [polypeptide binding]; other site
240292013043	catalytic site [active]
240292013044	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
240292013045	putative L-serine binding site [chemical binding]; other site
240292013046	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
240292013047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013048	S-adenosylmethionine binding site [chemical binding]; other site
240292013049	Uncharacterized conserved protein [Function unknown]; Region: COG2442
240292013050	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292013051	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292013052	catalytic residues [active]
240292013053	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
240292013054	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
240292013055	NAD(P) binding site [chemical binding]; other site
240292013056	homotetramer interface [polypeptide binding]; other site
240292013057	homodimer interface [polypeptide binding]; other site
240292013058	active site
240292013059	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
240292013060	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
240292013061	Mg++ binding site [ion binding]; other site
240292013062	putative catalytic motif [active]
240292013063	substrate binding site [chemical binding]; other site
240292013064	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
240292013065	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
240292013066	ring oligomerisation interface [polypeptide binding]; other site
240292013067	ATP/Mg binding site [chemical binding]; other site
240292013068	stacking interactions; other site
240292013069	hinge regions; other site
240292013070	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
240292013071	heme binding pocket [chemical binding]; other site
240292013072	heme ligand [chemical binding]; other site
240292013073	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
240292013074	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
240292013075	active site
240292013076	substrate binding site [chemical binding]; other site
240292013077	metal binding site [ion binding]; metal-binding site
240292013078	RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399
240292013079	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
240292013080	putative active site [active]
240292013081	adenylation catalytic residue [active]
240292013082	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013083	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292013084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013085	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292013086	putative active site [active]
240292013087	heme pocket [chemical binding]; other site
240292013088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013089	dimer interface [polypeptide binding]; other site
240292013090	phosphorylation site [posttranslational modification]
240292013091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013092	ATP binding site [chemical binding]; other site
240292013093	Mg2+ binding site [ion binding]; other site
240292013094	G-X-G motif; other site
240292013095	Response regulator receiver domain; Region: Response_reg; pfam00072
240292013096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013097	active site
240292013098	phosphorylation site [posttranslational modification]
240292013099	intermolecular recognition site; other site
240292013100	dimerization interface [polypeptide binding]; other site
240292013101	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292013102	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292013103	P-loop; other site
240292013104	Magnesium ion binding site [ion binding]; other site
240292013105	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292013106	Magnesium ion binding site [ion binding]; other site
240292013107	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292013108	putative active site [active]
240292013109	isoleucyl-tRNA synthetase; Region: PLN02843
240292013110	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
240292013111	HIGH motif; other site
240292013112	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
240292013113	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
240292013114	active site
240292013115	KMSKS motif; other site
240292013116	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
240292013117	tRNA binding surface [nucleotide binding]; other site
240292013118	anticodon binding site; other site
240292013119	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
240292013120	Response regulator receiver domain; Region: Response_reg; pfam00072
240292013121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013122	active site
240292013123	phosphorylation site [posttranslational modification]
240292013124	intermolecular recognition site; other site
240292013125	dimerization interface [polypeptide binding]; other site
240292013126	Response regulator receiver domain; Region: Response_reg; pfam00072
240292013127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013128	active site
240292013129	phosphorylation site [posttranslational modification]
240292013130	intermolecular recognition site; other site
240292013131	dimerization interface [polypeptide binding]; other site
240292013132	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
240292013133	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013134	GAF domain; Region: GAF; pfam01590
240292013135	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013136	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292013137	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013138	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292013139	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013140	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292013141	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
240292013142	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
240292013143	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
240292013144	dimer interface [polypeptide binding]; other site
240292013145	putative CheW interface [polypeptide binding]; other site
240292013146	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240292013147	putative binding surface; other site
240292013148	active site
240292013149	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
240292013150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013151	ATP binding site [chemical binding]; other site
240292013152	Mg2+ binding site [ion binding]; other site
240292013153	G-X-G motif; other site
240292013154	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
240292013155	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292013156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013157	active site
240292013158	phosphorylation site [posttranslational modification]
240292013159	intermolecular recognition site; other site
240292013160	dimerization interface [polypeptide binding]; other site
240292013161	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
240292013162	Low molecular weight phosphatase family; Region: LMWPc; cd00115
240292013163	active site
240292013164	Pirin-related protein [General function prediction only]; Region: COG1741
240292013165	Pirin; Region: Pirin; pfam02678
240292013166	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
240292013167	methionine sulfoxide reductase A; Provisional; Region: PRK13014
240292013168	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
240292013169	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
240292013170	molybdopterin cofactor binding site; other site
240292013171	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
240292013172	putative molybdopterin cofactor binding site; other site
240292013173	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
240292013174	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
240292013175	active site
240292013176	interdomain interaction site; other site
240292013177	putative metal-binding site [ion binding]; other site
240292013178	nucleotide binding site [chemical binding]; other site
240292013179	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
240292013180	domain I; other site
240292013181	DNA binding groove [nucleotide binding]
240292013182	phosphate binding site [ion binding]; other site
240292013183	domain II; other site
240292013184	domain III; other site
240292013185	nucleotide binding site [chemical binding]; other site
240292013186	catalytic site [active]
240292013187	domain IV; other site
240292013188	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240292013189	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
240292013190	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292013191	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
240292013192	Transposase domain (DUF772); Region: DUF772; pfam05598
240292013193	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292013194	DNA primase; Validated; Region: dnaG; PRK05667
240292013195	CHC2 zinc finger; Region: zf-CHC2; pfam01807
240292013196	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
240292013197	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
240292013198	active site
240292013199	metal binding site [ion binding]; metal-binding site
240292013200	interdomain interaction site; other site
240292013201	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292013202	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240292013203	active site
240292013204	metal binding site [ion binding]; metal-binding site
240292013205	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
240292013206	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
240292013207	DNA protecting protein DprA; Region: dprA; TIGR00732
240292013208	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
240292013209	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
240292013210	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292013211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013212	S-adenosylmethionine binding site [chemical binding]; other site
240292013213	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
240292013214	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
240292013215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292013216	FeS/SAM binding site; other site
240292013217	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
240292013218	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240292013219	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240292013220	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240292013221	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
240292013222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292013223	Coenzyme A binding pocket [chemical binding]; other site
240292013224	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
240292013225	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
240292013226	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
240292013227	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
240292013228	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292013229	gamma-glutamyl kinase; Provisional; Region: PRK05429
240292013230	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
240292013231	nucleotide binding site [chemical binding]; other site
240292013232	homotetrameric interface [polypeptide binding]; other site
240292013233	putative phosphate binding site [ion binding]; other site
240292013234	putative allosteric binding site; other site
240292013235	PUA domain; Region: PUA; pfam01472
240292013236	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292013237	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292013238	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
240292013239	Flavoprotein; Region: Flavoprotein; pfam02441
240292013240	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
240292013241	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
240292013242	putative hydrolase; Provisional; Region: PRK11460
240292013243	Predicted esterase [General function prediction only]; Region: COG0400
240292013244	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292013245	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
240292013246	TIR domain; Region: TIR_2; pfam13676
240292013247	TIR domain; Region: TIR_2; pfam13676
240292013248	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
240292013249	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
240292013250	purine monophosphate binding site [chemical binding]; other site
240292013251	dimer interface [polypeptide binding]; other site
240292013252	putative catalytic residues [active]
240292013253	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
240292013254	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
240292013255	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
240292013256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013257	PAS domain; Region: PAS_9; pfam13426
240292013258	putative active site [active]
240292013259	heme pocket [chemical binding]; other site
240292013260	PAS domain; Region: PAS; smart00091
240292013261	PAS fold; Region: PAS_4; pfam08448
240292013262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013263	PAS fold; Region: PAS_3; pfam08447
240292013264	putative active site [active]
240292013265	heme pocket [chemical binding]; other site
240292013266	PAS domain S-box; Region: sensory_box; TIGR00229
240292013267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013268	putative active site [active]
240292013269	heme pocket [chemical binding]; other site
240292013270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013271	PAS fold; Region: PAS_3; pfam08447
240292013272	putative active site [active]
240292013273	heme pocket [chemical binding]; other site
240292013274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013276	dimer interface [polypeptide binding]; other site
240292013277	phosphorylation site [posttranslational modification]
240292013278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013279	ATP binding site [chemical binding]; other site
240292013280	Mg2+ binding site [ion binding]; other site
240292013281	G-X-G motif; other site
240292013282	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292013283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013284	active site
240292013285	phosphorylation site [posttranslational modification]
240292013286	intermolecular recognition site; other site
240292013287	dimerization interface [polypeptide binding]; other site
240292013288	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
240292013289	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
240292013290	Ferritin-like domain; Region: Ferritin; pfam00210
240292013291	dimanganese center [ion binding]; other site
240292013292	Predicted membrane protein [Function unknown]; Region: COG2261
240292013293	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
240292013294	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
240292013295	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
240292013296	ResB-like family; Region: ResB; pfam05140
240292013297	XisI protein; Region: XisI; pfam08869
240292013298	XisH protein; Region: XisH; pfam08814
240292013299	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
240292013300	heme binding pocket [chemical binding]; other site
240292013301	heme ligand [chemical binding]; other site
240292013302	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
240292013303	HemN C-terminal domain; Region: HemN_C; pfam06969
240292013304	Uncharacterized conserved protein [Function unknown]; Region: COG4278
240292013305	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
240292013306	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
240292013307	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
240292013308	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
240292013309	active site
240292013310	NTP binding site [chemical binding]; other site
240292013311	metal binding triad [ion binding]; metal-binding site
240292013312	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
240292013313	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
240292013314	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
240292013315	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
240292013316	Glycoprotease family; Region: Peptidase_M22; pfam00814
240292013317	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
240292013318	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
240292013319	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
240292013320	Protein export membrane protein; Region: SecD_SecF; cl14618
240292013321	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240292013322	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240292013323	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292013324	phosphoenolpyruvate synthase; Validated; Region: PRK06464
240292013325	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
240292013326	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
240292013327	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
240292013328	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
240292013329	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
240292013330	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
240292013331	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; pfam02366
240292013332	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
240292013333	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
240292013334	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292013335	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292013336	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
240292013337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013339	dimer interface [polypeptide binding]; other site
240292013340	phosphorylation site [posttranslational modification]
240292013341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013342	ATP binding site [chemical binding]; other site
240292013343	Mg2+ binding site [ion binding]; other site
240292013344	G-X-G motif; other site
240292013345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292013346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013347	active site
240292013348	phosphorylation site [posttranslational modification]
240292013349	intermolecular recognition site; other site
240292013350	dimerization interface [polypeptide binding]; other site
240292013351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292013352	DNA binding residues [nucleotide binding]
240292013353	dimerization interface [polypeptide binding]; other site
240292013354	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
240292013355	GAF domain; Region: GAF; pfam01590
240292013356	Phytochrome region; Region: PHY; pfam00360
240292013357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013358	dimer interface [polypeptide binding]; other site
240292013359	phosphorylation site [posttranslational modification]
240292013360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013361	ATP binding site [chemical binding]; other site
240292013362	Mg2+ binding site [ion binding]; other site
240292013363	G-X-G motif; other site
240292013364	Response regulator receiver domain; Region: Response_reg; pfam00072
240292013365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013366	active site
240292013367	phosphorylation site [posttranslational modification]
240292013368	intermolecular recognition site; other site
240292013369	dimerization interface [polypeptide binding]; other site
240292013370	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292013371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013372	active site
240292013373	phosphorylation site [posttranslational modification]
240292013374	intermolecular recognition site; other site
240292013375	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013376	dimerization interface [polypeptide binding]; other site
240292013377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013378	dimer interface [polypeptide binding]; other site
240292013379	phosphorylation site [posttranslational modification]
240292013380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013381	ATP binding site [chemical binding]; other site
240292013382	Mg2+ binding site [ion binding]; other site
240292013383	G-X-G motif; other site
240292013384	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292013385	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292013386	acyl-activating enzyme (AAE) consensus motif; other site
240292013387	AMP binding site [chemical binding]; other site
240292013388	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292013389	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
240292013390	hypothetical protein; Provisional; Region: PRK06849
240292013391	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240292013392	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
240292013393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240292013394	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
240292013395	2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199
240292013396	active site
240292013397	metal binding site [ion binding]; metal-binding site
240292013398	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
240292013399	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292013400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292013401	motif II; other site
240292013402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292013403	AAA domain; Region: AAA_21; pfam13304
240292013404	Walker A/P-loop; other site
240292013405	ATP binding site [chemical binding]; other site
240292013406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292013407	ABC transporter signature motif; other site
240292013408	Walker B; other site
240292013409	D-loop; other site
240292013410	H-loop/switch region; other site
240292013411	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
240292013412	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
240292013413	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
240292013414	DNA binding residues [nucleotide binding]
240292013415	dimer interface [polypeptide binding]; other site
240292013416	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082
240292013417	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
240292013418	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240292013419	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240292013420	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
240292013421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013422	dimer interface [polypeptide binding]; other site
240292013423	phosphorylation site [posttranslational modification]
240292013424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013425	ATP binding site [chemical binding]; other site
240292013426	Mg2+ binding site [ion binding]; other site
240292013427	G-X-G motif; other site
240292013428	hypothetical protein; Provisional; Region: PRK02724
240292013429	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292013430	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292013431	active site
240292013432	ATP binding site [chemical binding]; other site
240292013433	substrate binding site [chemical binding]; other site
240292013434	activation loop (A-loop); other site
240292013435	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292013436	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292013437	structural tetrad; other site
240292013438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013439	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
240292013440	putative active site [active]
240292013441	heme pocket [chemical binding]; other site
240292013442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013443	putative active site [active]
240292013444	heme pocket [chemical binding]; other site
240292013445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292013446	putative active site [active]
240292013447	heme pocket [chemical binding]; other site
240292013448	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292013449	metal binding site [ion binding]; metal-binding site
240292013450	active site
240292013451	I-site; other site
240292013452	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292013453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292013454	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
240292013455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292013456	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
240292013457	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
240292013458	homotrimer interface [polypeptide binding]; other site
240292013459	Walker A motif; other site
240292013460	GTP binding site [chemical binding]; other site
240292013461	Walker B motif; other site
240292013462	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240292013463	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292013464	active site
240292013465	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
240292013466	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292013467	putative metal binding site; other site
240292013468	putative acyl transferase; Provisional; Region: PRK10502
240292013469	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
240292013470	putative trimer interface [polypeptide binding]; other site
240292013471	putative active site [active]
240292013472	putative substrate binding site [chemical binding]; other site
240292013473	putative CoA binding site [chemical binding]; other site
240292013474	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292013475	CHAT domain; Region: CHAT; cl17868
240292013476	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292013477	CHASE2 domain; Region: CHASE2; pfam05226
240292013478	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
240292013479	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
240292013480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013481	S-adenosylmethionine binding site [chemical binding]; other site
240292013482	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240292013483	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292013484	catalytic triad [active]
240292013485	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
240292013486	30S subunit binding site; other site
240292013487	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
240292013488	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
240292013489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292013490	substrate binding pocket [chemical binding]; other site
240292013491	membrane-bound complex binding site; other site
240292013492	hinge residues; other site
240292013493	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
240292013494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292013495	dimer interface [polypeptide binding]; other site
240292013496	conserved gate region; other site
240292013497	putative PBP binding loops; other site
240292013498	ABC-ATPase subunit interface; other site
240292013499	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
240292013500	Fatty acid desaturase; Region: FA_desaturase; pfam00487
240292013501	Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513
240292013502	putative di-iron ligands [ion binding]; other site
240292013503	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
240292013504	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
240292013505	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
240292013506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292013507	binding surface
240292013508	TPR motif; other site
240292013509	Uncharacterized conserved protein [Function unknown]; Region: COG2135
240292013510	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292013511	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
240292013512	putative C-terminal domain interface [polypeptide binding]; other site
240292013513	putative GSH binding site (G-site) [chemical binding]; other site
240292013514	putative dimer interface [polypeptide binding]; other site
240292013515	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
240292013516	N-terminal domain interface [polypeptide binding]; other site
240292013517	dimer interface [polypeptide binding]; other site
240292013518	substrate binding pocket (H-site) [chemical binding]; other site
240292013519	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
240292013520	Predicted membrane protein [Function unknown]; Region: COG4244
240292013521	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
240292013522	Hemerythrin-like domain; Region: Hr-like; cd12108
240292013523	Fe binding site [ion binding]; other site
240292013524	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
240292013525	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
240292013526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013527	S-adenosylmethionine binding site [chemical binding]; other site
240292013528	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
240292013529	nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans.  Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649
240292013530	active site
240292013531	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
240292013532	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
240292013533	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
240292013534	putative multimerization interface [polypeptide binding]; other site
240292013535	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
240292013536	active site
240292013537	catalytic triad [active]
240292013538	oxyanion hole [active]
240292013539	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
240292013540	multimerization interface [polypeptide binding]; other site
240292013541	RbcX protein; Region: RcbX; pfam02341
240292013542	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
240292013543	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
240292013544	homodimer interface [polypeptide binding]; other site
240292013545	active site
240292013546	heterodimer interface [polypeptide binding]; other site
240292013547	catalytic residue [active]
240292013548	metal binding site [ion binding]; metal-binding site
240292013549	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240292013550	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
240292013551	oligomerization interface [polypeptide binding]; other site
240292013552	active site
240292013553	metal binding site [ion binding]; metal-binding site
240292013554	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292013555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013556	S-adenosylmethionine binding site [chemical binding]; other site
240292013557	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
240292013558	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
240292013559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292013560	FeS/SAM binding site; other site
240292013561	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
240292013562	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292013563	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240292013564	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240292013565	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292013566	catalytic residue [active]
240292013567	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
240292013568	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
240292013569	trimerization site [polypeptide binding]; other site
240292013570	active site
240292013571	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
240292013572	NifU-like domain; Region: NifU; pfam01106
240292013573	nitrogenase reductase; Reviewed; Region: PRK13236
240292013574	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
240292013575	Nucleotide-binding sites [chemical binding]; other site
240292013576	Walker A motif; other site
240292013577	Switch I region of nucleotide binding site; other site
240292013578	Fe4S4 binding sites [ion binding]; other site
240292013579	Switch II region of nucleotide binding site; other site
240292013580	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
240292013581	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
240292013582	MoFe protein alpha/beta subunit interactions; other site
240292013583	Alpha subunit P cluster binding residues; other site
240292013584	FeMoco binding residues [chemical binding]; other site
240292013585	MoFe protein alpha subunit/Fe protein contacts; other site
240292013586	MoFe protein dimer/ dimer interactions; other site
240292013587	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240292013588	Cytochrome P450; Region: p450; pfam00067
240292013589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
240292013590	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292013591	putative active site [active]
240292013592	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292013593	putative active site [active]
240292013594	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292013595	active site
240292013596	catalytic residues [active]
240292013597	DNA binding site [nucleotide binding]
240292013598	Int/Topo IB signature motif; other site
240292013599	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
240292013600	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
240292013601	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
240292013602	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
240292013603	MoFe protein beta/alpha subunit interactions; other site
240292013604	Beta subunit P cluster binding residues; other site
240292013605	MoFe protein beta subunit/Fe protein contacts; other site
240292013606	MoFe protein dimer/ dimer interactions; other site
240292013607	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292013608	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
240292013609	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
240292013610	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
240292013611	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
240292013612	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
240292013613	Protein of unknown function, DUF269; Region: DUF269; pfam03270
240292013614	Rop-like; Region: Rop-like; pfam05082
240292013615	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
240292013616	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
240292013617	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
240292013618	ATP binding site [chemical binding]; other site
240292013619	substrate interface [chemical binding]; other site
240292013620	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
240292013621	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292013622	catalytic loop [active]
240292013623	iron binding site [ion binding]; other site
240292013624	FeoA domain; Region: FeoA; pfam04023
240292013625	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
240292013626	FOG: CBS domain [General function prediction only]; Region: COG0517
240292013627	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
240292013628	CP12 domain; Region: CP12; smart01093
240292013629	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292013630	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292013631	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
240292013632	NADPH bind site [chemical binding]; other site
240292013633	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
240292013634	putative FMN binding site [chemical binding]; other site
240292013635	NADPH bind site [chemical binding]; other site
240292013636	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
240292013637	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
240292013638	nickel binding site [ion binding]; other site
240292013639	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292013640	putative active site [active]
240292013641	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292013642	metal binding site [ion binding]; metal-binding site
240292013643	topology modulation protein; Reviewed; Region: PRK08118
240292013644	AAA domain; Region: AAA_17; pfam13207
240292013645	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
240292013646	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
240292013647	GatB domain; Region: GatB_Yqey; pfam02637
240292013648	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
240292013649	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
240292013650	trimer interface [polypeptide binding]; other site
240292013651	active site
240292013652	substrate binding site [chemical binding]; other site
240292013653	CoA binding site [chemical binding]; other site
240292013654	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
240292013655	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
240292013656	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
240292013657	active site
240292013658	catalytic residues [active]
240292013659	metal binding site [ion binding]; metal-binding site
240292013660	NifZ domain; Region: NifZ; pfam04319
240292013661	NifT/FixU protein; Region: NifT; cl02351
240292013662	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
240292013663	dimer interface [polypeptide binding]; other site
240292013664	[2Fe-2S] cluster binding site [ion binding]; other site
240292013665	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240292013666	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240292013667	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
240292013668	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
240292013669	homotetramer interface [polypeptide binding]; other site
240292013670	ligand binding site [chemical binding]; other site
240292013671	catalytic site [active]
240292013672	NAD binding site [chemical binding]; other site
240292013673	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
240292013674	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
240292013675	substrate binding site [chemical binding]; other site
240292013676	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
240292013677	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
240292013678	substrate binding site [chemical binding]; other site
240292013679	ligand binding site [chemical binding]; other site
240292013680	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
240292013681	short chain dehydrogenase; Provisional; Region: PRK06181
240292013682	NADP binding site [chemical binding]; other site
240292013683	homodimer interface [polypeptide binding]; other site
240292013684	substrate binding site [chemical binding]; other site
240292013685	active site
240292013686	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
240292013687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013688	S-adenosylmethionine binding site [chemical binding]; other site
240292013689	C factor cell-cell signaling protein; Provisional; Region: PRK09009
240292013690	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
240292013691	NADP binding site [chemical binding]; other site
240292013692	homodimer interface [polypeptide binding]; other site
240292013693	active site
240292013694	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292013695	non-specific DNA binding site [nucleotide binding]; other site
240292013696	salt bridge; other site
240292013697	sequence-specific DNA binding site [nucleotide binding]; other site
240292013698	PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921
240292013699	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
240292013700	Cache domain; Region: Cache_1; pfam02743
240292013701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013703	dimer interface [polypeptide binding]; other site
240292013704	phosphorylation site [posttranslational modification]
240292013705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013706	ATP binding site [chemical binding]; other site
240292013707	Mg2+ binding site [ion binding]; other site
240292013708	G-X-G motif; other site
240292013709	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292013710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013711	active site
240292013712	phosphorylation site [posttranslational modification]
240292013713	intermolecular recognition site; other site
240292013714	dimerization interface [polypeptide binding]; other site
240292013715	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292013716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292013717	active site
240292013718	phosphorylation site [posttranslational modification]
240292013719	intermolecular recognition site; other site
240292013720	dimerization interface [polypeptide binding]; other site
240292013721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292013723	dimer interface [polypeptide binding]; other site
240292013724	phosphorylation site [posttranslational modification]
240292013725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013726	ATP binding site [chemical binding]; other site
240292013727	Mg2+ binding site [ion binding]; other site
240292013728	G-X-G motif; other site
240292013729	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
240292013730	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
240292013731	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
240292013732	putative NAD(P) binding site [chemical binding]; other site
240292013733	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292013734	putative active site [active]
240292013735	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
240292013736	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
240292013737	Condensation domain; Region: Condensation; pfam00668
240292013738	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
240292013739	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292013740	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292013741	acyl-activating enzyme (AAE) consensus motif; other site
240292013742	AMP binding site [chemical binding]; other site
240292013743	Condensation domain; Region: Condensation; pfam00668
240292013744	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292013745	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
240292013746	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292013747	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240292013748	active site
240292013749	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292013750	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292013751	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
240292013752	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
240292013753	putative NADP binding site [chemical binding]; other site
240292013754	active site
240292013755	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292013756	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
240292013757	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292013758	active site
240292013759	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292013760	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240292013761	active site
240292013762	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292013763	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292013764	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
240292013765	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
240292013766	KR domain; Region: KR; pfam08659
240292013767	putative NADP binding site [chemical binding]; other site
240292013768	active site
240292013769	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292013770	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
240292013771	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
240292013772	acyl-activating enzyme (AAE) consensus motif; other site
240292013773	putative AMP binding site [chemical binding]; other site
240292013774	putative active site [active]
240292013775	putative CoA binding site [chemical binding]; other site
240292013776	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292013777	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
240292013778	active sites [active]
240292013779	tetramer interface [polypeptide binding]; other site
240292013780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292013781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292013782	putative substrate translocation pore; other site
240292013783	Thioesterase domain; Region: Thioesterase; pfam00975
240292013784	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
240292013785	nucleophilic elbow; other site
240292013786	catalytic triad; other site
240292013787	von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381
240292013788	pVHL-HIF-1alpha interaction [polypeptide binding]; other site
240292013789	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
240292013790	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
240292013791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292013792	Coenzyme A binding pocket [chemical binding]; other site
240292013793	Protein kinase domain; Region: Pkinase; pfam00069
240292013794	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292013795	active site
240292013796	ATP binding site [chemical binding]; other site
240292013797	substrate binding site [chemical binding]; other site
240292013798	activation loop (A-loop); other site
240292013799	AAA ATPase domain; Region: AAA_16; pfam13191
240292013800	Predicted ATPase [General function prediction only]; Region: COG3899
240292013801	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292013802	GAF domain; Region: GAF; pfam01590
240292013803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292013804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292013805	dimer interface [polypeptide binding]; other site
240292013806	phosphorylation site [posttranslational modification]
240292013807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292013808	ATP binding site [chemical binding]; other site
240292013809	Mg2+ binding site [ion binding]; other site
240292013810	G-X-G motif; other site
240292013811	Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406
240292013812	putative active site [active]
240292013813	putative metal binding site [ion binding]; other site
240292013814	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292013815	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
240292013816	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
240292013817	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
240292013818	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247
240292013819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
240292013820	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292013821	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
240292013822	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
240292013823	active site
240292013824	substrate binding site [chemical binding]; other site
240292013825	Mg2+ binding site [ion binding]; other site
240292013826	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
240292013827	Protein of unknown function (DUF1269); Region: DUF1269; pfam06897
240292013828	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
240292013829	translocation protein TolB; Provisional; Region: tolB; PRK04922
240292013830	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
240292013831	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
240292013832	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
240292013833	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
240292013834	active site
240292013835	catalytic triad [active]
240292013836	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
240292013837	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
240292013838	2TM domain; Region: 2TM; pfam13239
240292013839	Creatinine amidohydrolase; Region: Creatininase; pfam02633
240292013840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
240292013841	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
240292013842	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240292013843	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240292013844	nucleotide binding site [chemical binding]; other site
240292013845	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
240292013846	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
240292013847	putative substrate binding pocket [chemical binding]; other site
240292013848	catalytic triad [active]
240292013849	AB domain interface; other site
240292013850	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
240292013851	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
240292013852	putative active site [active]
240292013853	oxyanion strand; other site
240292013854	catalytic triad [active]
240292013855	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
240292013856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013857	S-adenosylmethionine binding site [chemical binding]; other site
240292013858	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
240292013859	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240292013860	Cytochrome c; Region: Cytochrom_C; pfam00034
240292013861	Transposase domain (DUF772); Region: DUF772; pfam05598
240292013862	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292013863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292013864	TPR motif; other site
240292013865	binding surface
240292013866	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240292013867	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
240292013868	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
240292013869	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240292013870	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292013871	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
240292013872	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
240292013873	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
240292013874	V-containing nitrogenase, delta subunit; Region: vnfG_nitrog; TIGR02930
240292013875	Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of  the VFe protein of the vanadium-dependent (V-) nitrogenase.  Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973
240292013876	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
240292013877	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
240292013878	Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins.  The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972
240292013879	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
240292013880	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
240292013881	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
240292013882	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
240292013883	Uncharacterized small protein [Function unknown]; Region: COG2886
240292013884	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
240292013885	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
240292013886	putative active site [active]
240292013887	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
240292013888	dimer interface [polypeptide binding]; other site
240292013889	FMN binding site [chemical binding]; other site
240292013890	NADPH bind site [chemical binding]; other site
240292013891	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
240292013892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292013893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292013894	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292013895	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292013896	Walker A/P-loop; other site
240292013897	ATP binding site [chemical binding]; other site
240292013898	Q-loop/lid; other site
240292013899	ABC transporter signature motif; other site
240292013900	Walker B; other site
240292013901	D-loop; other site
240292013902	H-loop/switch region; other site
240292013903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
240292013904	PBP superfamily domain; Region: PBP_like_2; pfam12849
240292013905	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292013906	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
240292013907	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
240292013908	active site
240292013909	catalytic residues [active]
240292013910	metal binding site [ion binding]; metal-binding site
240292013911	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240292013912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292013913	non-specific DNA binding site [nucleotide binding]; other site
240292013914	salt bridge; other site
240292013915	sequence-specific DNA binding site [nucleotide binding]; other site
240292013916	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292013917	PBP superfamily domain; Region: PBP_like; pfam12727
240292013918	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
240292013919	putative active site [active]
240292013920	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
240292013921	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
240292013922	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
240292013923	Nucleotide-binding sites [chemical binding]; other site
240292013924	Walker A motif; other site
240292013925	Switch I region of nucleotide binding site; other site
240292013926	Fe4S4 binding sites [ion binding]; other site
240292013927	Switch II region of nucleotide binding site; other site
240292013928	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
240292013929	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
240292013930	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
240292013931	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
240292013932	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
240292013933	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
240292013934	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
240292013935	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
240292013936	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
240292013937	nitrogenase reductase; Reviewed; Region: PRK13236
240292013938	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
240292013939	Nucleotide-binding sites [chemical binding]; other site
240292013940	Walker A motif; other site
240292013941	Switch I region of nucleotide binding site; other site
240292013942	Fe4S4 binding sites [ion binding]; other site
240292013943	Switch II region of nucleotide binding site; other site
240292013944	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240292013945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292013946	non-specific DNA binding site [nucleotide binding]; other site
240292013947	salt bridge; other site
240292013948	sequence-specific DNA binding site [nucleotide binding]; other site
240292013949	PBP superfamily domain; Region: PBP_like; pfam12727
240292013950	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292013951	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
240292013952	S-layer homology domain; Region: SLH; pfam00395
240292013953	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292013954	CARDB; Region: CARDB; pfam07705
240292013955	CARDB; Region: CARDB; pfam07705
240292013956	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
240292013957	catalytic triad [active]
240292013958	putative active site [active]
240292013959	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
240292013960	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292013961	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240292013962	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240292013963	Cytochrome P450; Region: p450; cl12078
240292013964	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
240292013965	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
240292013966	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292013967	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292013968	substrate binding pocket [chemical binding]; other site
240292013969	membrane-bound complex binding site; other site
240292013970	hinge residues; other site
240292013971	putative oxidoreductase; Provisional; Region: PRK08275
240292013972	L-aspartate oxidase; Provisional; Region: PRK06175
240292013973	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240292013974	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292013975	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292013976	Coenzyme A binding pocket [chemical binding]; other site
240292013977	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
240292013978	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292013979	motif II; other site
240292013980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240292013981	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292013982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292013983	S-adenosylmethionine binding site [chemical binding]; other site
240292013984	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292013985	Coenzyme A binding pocket [chemical binding]; other site
240292013986	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
240292013987	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292013988	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
240292013989	HEAT repeats; Region: HEAT_2; pfam13646
240292013990	protein binding surface [polypeptide binding]; other site
240292013991	HEAT repeats; Region: HEAT_2; pfam13646
240292013992	HEAT repeats; Region: HEAT_2; pfam13646
240292013993	HEAT repeats; Region: HEAT_2; pfam13646
240292013994	antiporter inner membrane protein; Provisional; Region: PRK11670
240292013995	Domain of unknown function DUF59; Region: DUF59; pfam01883
240292013996	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
240292013997	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
240292013998	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
240292013999	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
240292014000	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
240292014001	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
240292014002	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
240292014003	homodimer interface [polypeptide binding]; other site
240292014004	substrate-cofactor binding pocket; other site
240292014005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014006	catalytic residue [active]
240292014007	Sulphur transport; Region: Sulf_transp; pfam04143
240292014008	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
240292014009	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
240292014010	active site residue [active]
240292014011	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
240292014012	active site residue [active]
240292014013	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
240292014014	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
240292014015	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014016	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292014017	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014018	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014019	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292014020	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014021	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014022	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
240292014023	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292014024	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292014025	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292014026	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292014027	motif II; other site
240292014028	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292014029	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292014030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014031	active site
240292014032	phosphorylation site [posttranslational modification]
240292014033	intermolecular recognition site; other site
240292014034	dimerization interface [polypeptide binding]; other site
240292014035	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292014036	DNA binding site [nucleotide binding]
240292014037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292014038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014039	dimer interface [polypeptide binding]; other site
240292014040	phosphorylation site [posttranslational modification]
240292014041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014042	ATP binding site [chemical binding]; other site
240292014043	Mg2+ binding site [ion binding]; other site
240292014044	G-X-G motif; other site
240292014045	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
240292014046	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292014047	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292014048	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292014049	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292014050	motif II; other site
240292014051	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292014052	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
240292014053	30S subunit binding site; other site
240292014054	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240292014055	DNA-binding site [nucleotide binding]; DNA binding site
240292014056	RNA-binding motif; other site
240292014057	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292014058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014059	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014060	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
240292014061	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
240292014062	metal binding site [ion binding]; metal-binding site
240292014063	dimer interface [polypeptide binding]; other site
240292014064	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
240292014065	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
240292014066	active site
240292014067	metal binding site [ion binding]; metal-binding site
240292014068	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240292014069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014070	active site
240292014071	phosphorylation site [posttranslational modification]
240292014072	intermolecular recognition site; other site
240292014073	dimerization interface [polypeptide binding]; other site
240292014074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292014075	DNA binding residues [nucleotide binding]
240292014076	dimerization interface [polypeptide binding]; other site
240292014077	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
240292014078	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240292014079	Condensation domain; Region: Condensation; pfam00668
240292014080	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292014081	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292014082	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292014083	acyl-activating enzyme (AAE) consensus motif; other site
240292014084	AMP binding site [chemical binding]; other site
240292014085	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292014086	Condensation domain; Region: Condensation; pfam00668
240292014087	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292014088	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
240292014089	Condensation domain; Region: Condensation; pfam00668
240292014090	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292014091	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
240292014092	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
240292014093	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292014094	acyl-activating enzyme (AAE) consensus motif; other site
240292014095	AMP binding site [chemical binding]; other site
240292014096	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292014097	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240292014098	H+ Antiporter protein; Region: 2A0121; TIGR00900
240292014099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292014100	putative substrate translocation pore; other site
240292014101	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
240292014102	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292014103	DevC protein; Region: devC; TIGR01185
240292014104	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240292014105	FtsX-like permease family; Region: FtsX; pfam02687
240292014106	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
240292014107	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240292014108	Walker A/P-loop; other site
240292014109	ATP binding site [chemical binding]; other site
240292014110	Q-loop/lid; other site
240292014111	ABC transporter signature motif; other site
240292014112	Walker B; other site
240292014113	D-loop; other site
240292014114	H-loop/switch region; other site
240292014115	Protein kinase domain; Region: Pkinase; pfam00069
240292014116	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292014117	active site
240292014118	ATP binding site [chemical binding]; other site
240292014119	substrate binding site [chemical binding]; other site
240292014120	activation loop (A-loop); other site
240292014121	acyl-CoA synthetase; Validated; Region: PRK05850
240292014122	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
240292014123	acyl-activating enzyme (AAE) consensus motif; other site
240292014124	active site
240292014125	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292014126	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240292014127	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292014128	active site
240292014129	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292014130	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292014131	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292014132	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
240292014133	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292014134	inhibitor-cofactor binding pocket; inhibition site
240292014135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014136	catalytic residue [active]
240292014137	Condensation domain; Region: Condensation; pfam00668
240292014138	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292014139	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292014140	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292014141	acyl-activating enzyme (AAE) consensus motif; other site
240292014142	AMP binding site [chemical binding]; other site
240292014143	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292014144	Caspase domain; Region: Peptidase_C14; pfam00656
240292014145	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
240292014146	substrate binding site [chemical binding]; other site
240292014147	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
240292014148	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
240292014149	indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394
240292014150	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
240292014151	dimer interface [polypeptide binding]; other site
240292014152	PYR/PP interface [polypeptide binding]; other site
240292014153	TPP binding site [chemical binding]; other site
240292014154	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240292014155	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
240292014156	TPP-binding site [chemical binding]; other site
240292014157	dimer interface [polypeptide binding]; other site
240292014158	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
240292014159	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
240292014160	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
240292014161	NAD(P) binding site [chemical binding]; other site
240292014162	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
240292014163	pheophytin binding site; other site
240292014164	chlorophyll binding site; other site
240292014165	quinone binding site; other site
240292014166	Fe binding site [ion binding]; other site
240292014167	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
240292014168	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
240292014169	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292014170	active site
240292014171	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292014172	active site
240292014173	Probable transposase; Region: OrfB_IS605; pfam01385
240292014174	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292014175	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
240292014176	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292014177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292014178	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292014179	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
240292014180	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292014181	putative active site [active]
240292014182	putative metal binding site [ion binding]; other site
240292014183	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
240292014184	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292014185	haemagglutination activity domain; Region: Haemagg_act; pfam05860
240292014186	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
240292014187	active site
240292014188	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292014189	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292014190	CHASE2 domain; Region: CHASE2; pfam05226
240292014191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014192	dimer interface [polypeptide binding]; other site
240292014193	phosphorylation site [posttranslational modification]
240292014194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014195	ATP binding site [chemical binding]; other site
240292014196	Mg2+ binding site [ion binding]; other site
240292014197	G-X-G motif; other site
240292014198	Response regulator receiver domain; Region: Response_reg; pfam00072
240292014199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014200	active site
240292014201	phosphorylation site [posttranslational modification]
240292014202	intermolecular recognition site; other site
240292014203	dimerization interface [polypeptide binding]; other site
240292014204	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292014205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014206	active site
240292014207	phosphorylation site [posttranslational modification]
240292014208	intermolecular recognition site; other site
240292014209	dimerization interface [polypeptide binding]; other site
240292014210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014211	dimer interface [polypeptide binding]; other site
240292014212	phosphorylation site [posttranslational modification]
240292014213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014214	ATP binding site [chemical binding]; other site
240292014215	Mg2+ binding site [ion binding]; other site
240292014216	G-X-G motif; other site
240292014217	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292014218	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292014219	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292014220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240292014221	binding surface
240292014222	TPR motif; other site
240292014223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292014224	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
240292014225	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292014226	Walker A/P-loop; other site
240292014227	ATP binding site [chemical binding]; other site
240292014228	Q-loop/lid; other site
240292014229	ABC transporter signature motif; other site
240292014230	Walker B; other site
240292014231	D-loop; other site
240292014232	H-loop/switch region; other site
240292014233	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292014234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292014235	dimer interface [polypeptide binding]; other site
240292014236	conserved gate region; other site
240292014237	putative PBP binding loops; other site
240292014238	ABC-ATPase subunit interface; other site
240292014239	S-layer homology domain; Region: SLH; pfam00395
240292014240	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292014241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292014242	S-adenosylmethionine binding site [chemical binding]; other site
240292014243	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
240292014244	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
240292014245	active site
240292014246	non-prolyl cis peptide bond; other site
240292014247	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240292014248	Predicted esterase [General function prediction only]; Region: COG0400
240292014249	putative hydrolase; Provisional; Region: PRK11460
240292014250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292014251	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292014252	active site
240292014253	catalytic tetrad [active]
240292014254	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292014255	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292014256	substrate binding pocket [chemical binding]; other site
240292014257	membrane-bound complex binding site; other site
240292014258	hinge residues; other site
240292014259	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292014260	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292014261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292014262	Walker A/P-loop; other site
240292014263	ATP binding site [chemical binding]; other site
240292014264	Q-loop/lid; other site
240292014265	ABC transporter signature motif; other site
240292014266	Walker B; other site
240292014267	D-loop; other site
240292014268	H-loop/switch region; other site
240292014269	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292014270	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
240292014271	Cache domain; Region: Cache_1; pfam02743
240292014272	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292014273	dimerization interface [polypeptide binding]; other site
240292014274	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292014275	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292014276	metal binding site [ion binding]; metal-binding site
240292014277	active site
240292014278	I-site; other site
240292014279	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240292014280	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240292014281	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
240292014282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292014283	Walker A/P-loop; other site
240292014284	ATP binding site [chemical binding]; other site
240292014285	Q-loop/lid; other site
240292014286	ABC transporter signature motif; other site
240292014287	Walker B; other site
240292014288	D-loop; other site
240292014289	H-loop/switch region; other site
240292014290	Dienelactone hydrolase family; Region: DLH; pfam01738
240292014291	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
240292014292	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
240292014293	dimer interface [polypeptide binding]; other site
240292014294	FMN binding site [chemical binding]; other site
240292014295	NADPH bind site [chemical binding]; other site
240292014296	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292014297	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292014298	substrate binding pocket [chemical binding]; other site
240292014299	membrane-bound complex binding site; other site
240292014300	hinge residues; other site
240292014301	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
240292014302	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
240292014303	homodimer interface [polypeptide binding]; other site
240292014304	substrate-cofactor binding pocket; other site
240292014305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014306	catalytic residue [active]
240292014307	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
240292014308	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240292014309	dimer interface [polypeptide binding]; other site
240292014310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014311	catalytic residue [active]
240292014312	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
240292014313	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292014314	homodimer interface [polypeptide binding]; other site
240292014315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014316	catalytic residue [active]
240292014317	Putative phosphatase (DUF442); Region: DUF442; cl17385
240292014318	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
240292014319	VCBS repeat; Region: VCBS_repeat; TIGR01965
240292014320	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
240292014321	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
240292014322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292014323	dimer interface [polypeptide binding]; other site
240292014324	conserved gate region; other site
240292014325	putative PBP binding loops; other site
240292014326	ABC-ATPase subunit interface; other site
240292014327	WYL domain; Region: WYL; pfam13280
240292014328	CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain; Region: Cas3_I-D; cd09710
240292014329	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
240292014330	Uncharacterized conserved protein [Function unknown]; Region: COG2442
240292014331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
240292014332	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
240292014333	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
240292014334	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
240292014335	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
240292014336	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
240292014337	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
240292014338	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
240292014339	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
240292014340	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
240292014341	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
240292014342	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
240292014343	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
240292014344	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
240292014345	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
240292014346	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
240292014347	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
240292014348	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
240292014349	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
240292014350	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292014351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
240292014352	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292014353	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292014354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292014355	TIR domain; Region: TIR_2; pfam13676
240292014356	TIR domain; Region: TIR_2; pfam13676
240292014357	TIR domain; Region: TIR_2; pfam13676
240292014358	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292014359	CHASE2 domain; Region: CHASE2; pfam05226
240292014360	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292014361	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
240292014362	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
240292014363	Ferritin-like; Region: Ferritin-like; pfam12902
240292014364	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014365	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292014366	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014367	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014368	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
240292014369	UV-endonuclease UvdE; Region: UvdE; cl10036
240292014370	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
240292014371	L-ascorbate oxidase, fungal type; Region: ascorbOXfungal; TIGR03390
240292014372	Multicopper oxidase; Region: Cu-oxidase; pfam00394
240292014373	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
240292014374	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
240292014375	SnoaL-like domain; Region: SnoaL_3; pfam13474
240292014376	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
240292014377	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
240292014378	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
240292014379	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
240292014380	Major royal jelly protein; Region: MRJP; pfam03022
240292014381	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
240292014382	Domain interface; other site
240292014383	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
240292014384	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
240292014385	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
240292014386	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
240292014387	dimerization interface [polypeptide binding]; other site
240292014388	domain crossover interface; other site
240292014389	redox-dependent activation switch; other site
240292014390	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292014391	putative active site [active]
240292014392	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292014393	Ligand Binding Site [chemical binding]; other site
240292014394	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
240292014395	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
240292014396	NAD binding site [chemical binding]; other site
240292014397	dimerization interface [polypeptide binding]; other site
240292014398	product binding site; other site
240292014399	substrate binding site [chemical binding]; other site
240292014400	zinc binding site [ion binding]; other site
240292014401	catalytic residues [active]
240292014402	ribosomal protein S20; Region: rps20; CHL00102
240292014403	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
240292014404	active site
240292014405	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
240292014406	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
240292014407	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
240292014408	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
240292014409	RPB10 interaction site [polypeptide binding]; other site
240292014410	RPB1 interaction site [polypeptide binding]; other site
240292014411	RPB11 interaction site [polypeptide binding]; other site
240292014412	RPB3 interaction site [polypeptide binding]; other site
240292014413	RPB12 interaction site [polypeptide binding]; other site
240292014414	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
240292014415	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
240292014416	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
240292014417	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
240292014418	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
240292014419	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
240292014420	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
240292014421	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
240292014422	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
240292014423	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
240292014424	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
240292014425	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
240292014426	DNA binding site [nucleotide binding]
240292014427	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
240292014428	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
240292014429	Domain of unknown function (DUF3474); Region: DUF3474; pfam11960
240292014430	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
240292014431	putative di-iron ligands [ion binding]; other site
240292014432	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
240292014433	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
240292014434	putative di-iron ligands [ion binding]; other site
240292014435	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
240292014436	Fatty acid desaturase; Region: FA_desaturase; pfam00487
240292014437	Di-iron ligands [ion binding]; other site
240292014438	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
240292014439	Aluminium resistance protein; Region: Alum_res; pfam06838
240292014440	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
240292014441	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
240292014442	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
240292014443	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
240292014444	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
240292014445	putative active site [active]
240292014446	Double zinc ribbon; Region: DZR; pfam12773
240292014447	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
240292014448	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240292014449	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292014450	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292014451	phosphopeptide binding site; other site
240292014452	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
240292014453	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
240292014454	Stage II sporulation protein; Region: SpoIID; pfam08486
240292014455	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
240292014456	Haemolytic domain; Region: Haemolytic; pfam01809
240292014457	Predicted membrane protein [Function unknown]; Region: COG1836
240292014458	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
240292014459	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
240292014460	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292014461	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
240292014462	putative active site [active]
240292014463	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292014464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292014465	Walker A/P-loop; other site
240292014466	ATP binding site [chemical binding]; other site
240292014467	Q-loop/lid; other site
240292014468	ABC transporter signature motif; other site
240292014469	Walker B; other site
240292014470	D-loop; other site
240292014471	H-loop/switch region; other site
240292014472	CARDB; Region: CARDB; pfam07705
240292014473	Uncharacterized conserved protein [Function unknown]; Region: COG1572
240292014474	CARDB; Region: CARDB; pfam07705
240292014475	CARDB; Region: CARDB; pfam07705
240292014476	CARDB; Region: CARDB; pfam07705
240292014477	CARDB; Region: CARDB; pfam07705
240292014478	CARDB; Region: CARDB; pfam07705
240292014479	CARDB; Region: CARDB; pfam07705
240292014480	CARDB; Region: CARDB; pfam07705
240292014481	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
240292014482	catalytic triad [active]
240292014483	putative active site [active]
240292014484	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
240292014485	S-layer homology domain; Region: SLH; pfam00395
240292014486	S-layer homology domain; Region: SLH; pfam00395
240292014487	S-layer homology domain; Region: SLH; pfam00395
240292014488	S-layer homology domain; Region: SLH; pfam00395
240292014489	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292014490	putative active site [active]
240292014491	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240292014492	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240292014493	Walker A/P-loop; other site
240292014494	ATP binding site [chemical binding]; other site
240292014495	Q-loop/lid; other site
240292014496	ABC transporter signature motif; other site
240292014497	Walker B; other site
240292014498	D-loop; other site
240292014499	H-loop/switch region; other site
240292014500	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
240292014501	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
240292014502	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
240292014503	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
240292014504	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
240292014505	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
240292014506	putative active site [active]
240292014507	putative substrate binding site [chemical binding]; other site
240292014508	putative cosubstrate binding site; other site
240292014509	catalytic site [active]
240292014510	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
240292014511	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
240292014512	metal-binding site [ion binding]
240292014513	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292014514	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292014515	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
240292014516	DNA binding residues [nucleotide binding]
240292014517	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
240292014518	dimer interface [polypeptide binding]; other site
240292014519	metal binding site [ion binding]; metal-binding site
240292014520	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
240292014521	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
240292014522	NAD binding site [chemical binding]; other site
240292014523	ligand binding site [chemical binding]; other site
240292014524	catalytic site [active]
240292014525	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240292014526	Uncharacterized conserved protein [Function unknown]; Region: COG1262
240292014527	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
240292014528	Sulfatase; Region: Sulfatase; pfam00884
240292014529	NifT/FixU protein; Region: NifT; pfam06988
240292014530	NifZ domain; Region: NifZ; pfam04319
240292014531	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
240292014532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292014533	FeS/SAM binding site; other site
240292014534	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
240292014535	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240292014536	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240292014537	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292014538	catalytic residue [active]
240292014539	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
240292014540	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
240292014541	trimerization site [polypeptide binding]; other site
240292014542	active site
240292014543	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
240292014544	NifU-like domain; Region: NifU; pfam01106
240292014545	nitrogenase reductase; Reviewed; Region: PRK13236
240292014546	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
240292014547	Nucleotide-binding sites [chemical binding]; other site
240292014548	Walker A motif; other site
240292014549	Switch I region of nucleotide binding site; other site
240292014550	Fe4S4 binding sites [ion binding]; other site
240292014551	Switch II region of nucleotide binding site; other site
240292014552	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
240292014553	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
240292014554	MoFe protein alpha/beta subunit interactions; other site
240292014555	Alpha subunit P cluster binding residues; other site
240292014556	FeMoco binding residues [chemical binding]; other site
240292014557	MoFe protein alpha subunit/Fe protein contacts; other site
240292014558	MoFe protein dimer/ dimer interactions; other site
240292014559	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
240292014560	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
240292014561	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
240292014562	MoFe protein beta/alpha subunit interactions; other site
240292014563	Beta subunit P cluster binding residues; other site
240292014564	MoFe protein beta subunit/Fe protein contacts; other site
240292014565	MoFe protein dimer/ dimer interactions; other site
240292014566	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292014567	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
240292014568	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
240292014569	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
240292014570	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
240292014571	Protein of unknown function, DUF269; Region: DUF269; pfam03270
240292014572	Rop-like; Region: Rop-like; pfam05082
240292014573	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
240292014574	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
240292014575	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
240292014576	ATP binding site [chemical binding]; other site
240292014577	substrate interface [chemical binding]; other site
240292014578	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
240292014579	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292014580	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292014581	catalytic loop [active]
240292014582	iron binding site [ion binding]; other site
240292014583	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
240292014584	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292014585	4Fe-4S binding domain; Region: Fer4; pfam00037
240292014586	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292014587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292014588	non-specific DNA binding site [nucleotide binding]; other site
240292014589	salt bridge; other site
240292014590	sequence-specific DNA binding site [nucleotide binding]; other site
240292014591	Restriction endonuclease; Region: Mrr_cat; pfam04471
240292014592	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
240292014593	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
240292014594	TPP-binding site [chemical binding]; other site
240292014595	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
240292014596	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
240292014597	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292014598	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
240292014599	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014600	GAF domain; Region: GAF; pfam01590
240292014601	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014602	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292014603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014604	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292014605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292014606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014607	dimer interface [polypeptide binding]; other site
240292014608	phosphorylation site [posttranslational modification]
240292014609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014610	ATP binding site [chemical binding]; other site
240292014611	Mg2+ binding site [ion binding]; other site
240292014612	G-X-G motif; other site
240292014613	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
240292014614	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292014615	P loop; other site
240292014616	Nucleotide binding site [chemical binding]; other site
240292014617	DTAP/Switch II; other site
240292014618	Switch I; other site
240292014619	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
240292014620	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
240292014621	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
240292014622	Uncharacterized conserved protein [Function unknown]; Region: COG5464
240292014623	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
240292014624	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
240292014625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
240292014626	Predicted permeases [General function prediction only]; Region: COG0679
240292014627	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240292014628	HSP70 interaction site [polypeptide binding]; other site
240292014629	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
240292014630	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
240292014631	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
240292014632	tetramer interface [polypeptide binding]; other site
240292014633	TPP-binding site [chemical binding]; other site
240292014634	heterodimer interface [polypeptide binding]; other site
240292014635	phosphorylation loop region [posttranslational modification]
240292014636	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
240292014637	active site
240292014638	catalytic residues [active]
240292014639	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
240292014640	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
240292014641	putative active site [active]
240292014642	putative dimer interface [polypeptide binding]; other site
240292014643	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
240292014644	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240292014645	Uncharacterized conserved protein [Function unknown]; Region: COG4301
240292014646	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
240292014647	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
240292014648	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
240292014649	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
240292014650	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240292014651	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
240292014652	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
240292014653	catalytic triad [active]
240292014654	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
240292014655	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292014656	putative ADP-binding pocket [chemical binding]; other site
240292014657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292014658	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
240292014659	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
240292014660	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
240292014661	dimer interface [polypeptide binding]; other site
240292014662	catalytic triad [active]
240292014663	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
240292014664	Cupin domain; Region: Cupin_2; cl17218
240292014665	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
240292014666	DNA photolyase; Region: DNA_photolyase; pfam00875
240292014667	Response regulator receiver domain; Region: Response_reg; pfam00072
240292014668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014669	active site
240292014670	phosphorylation site [posttranslational modification]
240292014671	intermolecular recognition site; other site
240292014672	dimerization interface [polypeptide binding]; other site
240292014673	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
240292014674	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
240292014675	GIY-YIG motif/motif A; other site
240292014676	active site
240292014677	catalytic site [active]
240292014678	putative DNA binding site [nucleotide binding]; other site
240292014679	metal binding site [ion binding]; metal-binding site
240292014680	UvrB/uvrC motif; Region: UVR; pfam02151
240292014681	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
240292014682	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
240292014683	Predicted membrane protein [Function unknown]; Region: COG4244
240292014684	Predicted membrane protein [Function unknown]; Region: COG4244
240292014685	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
240292014686	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
240292014687	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240292014688	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240292014689	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
240292014690	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240292014691	Subunit I/III interface [polypeptide binding]; other site
240292014692	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
240292014693	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
240292014694	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292014695	RNA binding surface [nucleotide binding]; other site
240292014696	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
240292014697	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292014698	membrane-bound complex binding site; other site
240292014699	hinge residues; other site
240292014700	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292014701	dimerization interface [polypeptide binding]; other site
240292014702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292014703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292014704	dimer interface [polypeptide binding]; other site
240292014705	phosphorylation site [posttranslational modification]
240292014706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014707	ATP binding site [chemical binding]; other site
240292014708	Mg2+ binding site [ion binding]; other site
240292014709	G-X-G motif; other site
240292014710	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292014711	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014712	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292014713	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
240292014714	ATP-grasp domain; Region: ATP-grasp; pfam02222
240292014715	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292014716	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292014717	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292014718	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292014719	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292014720	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292014721	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292014722	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292014723	Predicted membrane protein [Function unknown]; Region: COG1950
240292014724	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014725	Ankyrin repeat; Region: Ank; pfam00023
240292014726	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014727	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292014728	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014729	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292014730	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014731	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014732	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240292014733	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240292014734	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
240292014735	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
240292014736	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
240292014737	NADH(P)-binding; Region: NAD_binding_10; pfam13460
240292014738	NAD(P) binding site [chemical binding]; other site
240292014739	putative active site [active]
240292014740	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
240292014741	N-acetyl-D-glucosamine binding site [chemical binding]; other site
240292014742	catalytic residue [active]
240292014743	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
240292014744	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014745	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292014746	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
240292014747	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
240292014748	folate binding site [chemical binding]; other site
240292014749	NADP+ binding site [chemical binding]; other site
240292014750	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
240292014751	putative homodimer interface [polypeptide binding]; other site
240292014752	putative homotetramer interface [polypeptide binding]; other site
240292014753	putative metal binding site [ion binding]; other site
240292014754	putative homodimer-homodimer interface [polypeptide binding]; other site
240292014755	putative allosteric switch controlling residues; other site
240292014756	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
240292014757	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292014758	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240292014759	protein binding site [polypeptide binding]; other site
240292014760	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
240292014761	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292014762	active site
240292014763	catalytic tetrad [active]
240292014764	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
240292014765	FOG: CBS domain [General function prediction only]; Region: COG0517
240292014766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014767	putative active site [active]
240292014768	PAS fold; Region: PAS_3; pfam08447
240292014769	heme pocket [chemical binding]; other site
240292014770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014771	PAS fold; Region: PAS_3; pfam08447
240292014772	putative active site [active]
240292014773	heme pocket [chemical binding]; other site
240292014774	PAS domain S-box; Region: sensory_box; TIGR00229
240292014775	PAS domain; Region: PAS; smart00091
240292014776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014777	PAS fold; Region: PAS_3; pfam08447
240292014778	putative active site [active]
240292014779	heme pocket [chemical binding]; other site
240292014780	PAS domain; Region: PAS_9; pfam13426
240292014781	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292014782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014783	putative active site [active]
240292014784	heme pocket [chemical binding]; other site
240292014785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014786	PAS fold; Region: PAS_3; pfam08447
240292014787	putative active site [active]
240292014788	heme pocket [chemical binding]; other site
240292014789	PAS fold; Region: PAS_4; pfam08448
240292014790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014791	putative active site [active]
240292014792	heme pocket [chemical binding]; other site
240292014793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014794	PAS domain; Region: PAS_9; pfam13426
240292014795	putative active site [active]
240292014796	heme pocket [chemical binding]; other site
240292014797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240292014798	Histidine kinase; Region: HisKA_2; pfam07568
240292014799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014800	ATP binding site [chemical binding]; other site
240292014801	Mg2+ binding site [ion binding]; other site
240292014802	G-X-G motif; other site
240292014803	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292014804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014805	active site
240292014806	phosphorylation site [posttranslational modification]
240292014807	intermolecular recognition site; other site
240292014808	dimerization interface [polypeptide binding]; other site
240292014809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014810	putative active site [active]
240292014811	heme pocket [chemical binding]; other site
240292014812	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292014813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014814	dimer interface [polypeptide binding]; other site
240292014815	phosphorylation site [posttranslational modification]
240292014816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014817	ATP binding site [chemical binding]; other site
240292014818	Mg2+ binding site [ion binding]; other site
240292014819	G-X-G motif; other site
240292014820	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
240292014821	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
240292014822	putative NAD(P) binding site [chemical binding]; other site
240292014823	putative active site [active]
240292014824	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
240292014825	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
240292014826	substrate binding pocket [chemical binding]; other site
240292014827	active site
240292014828	iron coordination sites [ion binding]; other site
240292014829	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
240292014830	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
240292014831	active site
240292014832	non-prolyl cis peptide bond; other site
240292014833	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
240292014834	EamA-like transporter family; Region: EamA; pfam00892
240292014835	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
240292014836	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
240292014837	conserved cys residue [active]
240292014838	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292014839	Acid Phosphatase; Region: Acid_PPase; cl17256
240292014840	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292014841	motif II; other site
240292014842	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
240292014843	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240292014844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292014845	homodimer interface [polypeptide binding]; other site
240292014846	catalytic residue [active]
240292014847	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
240292014848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292014849	S-adenosylmethionine binding site [chemical binding]; other site
240292014850	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
240292014851	dimer interface [polypeptide binding]; other site
240292014852	motif 1; other site
240292014853	active site
240292014854	motif 2; other site
240292014855	motif 3; other site
240292014856	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
240292014857	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
240292014858	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
240292014859	Competence protein; Region: Competence; pfam03772
240292014860	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
240292014861	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240292014862	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240292014863	nucleotide binding site [chemical binding]; other site
240292014864	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
240292014865	putative dimer interface [polypeptide binding]; other site
240292014866	putative [2Fe-2S] cluster binding site [ion binding]; other site
240292014867	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292014868	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292014869	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
240292014870	Walker A/P-loop; other site
240292014871	ATP binding site [chemical binding]; other site
240292014872	Q-loop/lid; other site
240292014873	ABC transporter signature motif; other site
240292014874	Walker B; other site
240292014875	D-loop; other site
240292014876	H-loop/switch region; other site
240292014877	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292014878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014879	active site
240292014880	phosphorylation site [posttranslational modification]
240292014881	intermolecular recognition site; other site
240292014882	dimerization interface [polypeptide binding]; other site
240292014883	PAS domain S-box; Region: sensory_box; TIGR00229
240292014884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014885	putative active site [active]
240292014886	heme pocket [chemical binding]; other site
240292014887	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292014888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014889	putative active site [active]
240292014890	heme pocket [chemical binding]; other site
240292014891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014892	dimer interface [polypeptide binding]; other site
240292014893	phosphorylation site [posttranslational modification]
240292014894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014895	ATP binding site [chemical binding]; other site
240292014896	Mg2+ binding site [ion binding]; other site
240292014897	G-X-G motif; other site
240292014898	Response regulator receiver domain; Region: Response_reg; pfam00072
240292014899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014900	active site
240292014901	phosphorylation site [posttranslational modification]
240292014902	intermolecular recognition site; other site
240292014903	dimerization interface [polypeptide binding]; other site
240292014904	Response regulator receiver domain; Region: Response_reg; pfam00072
240292014905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014906	active site
240292014907	phosphorylation site [posttranslational modification]
240292014908	intermolecular recognition site; other site
240292014909	dimerization interface [polypeptide binding]; other site
240292014910	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014911	GAF domain; Region: GAF; pfam01590
240292014912	PAS fold; Region: PAS_4; pfam08448
240292014913	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014914	putative active site [active]
240292014915	heme pocket [chemical binding]; other site
240292014916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292014917	PAS fold; Region: PAS_3; pfam08447
240292014918	putative active site [active]
240292014919	heme pocket [chemical binding]; other site
240292014920	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292014921	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292014922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292014923	dimer interface [polypeptide binding]; other site
240292014924	phosphorylation site [posttranslational modification]
240292014925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
240292014926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292014927	ATP binding site [chemical binding]; other site
240292014928	G-X-G motif; other site
240292014929	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
240292014930	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
240292014931	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292014932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292014933	active site
240292014934	phosphorylation site [posttranslational modification]
240292014935	intermolecular recognition site; other site
240292014936	dimerization interface [polypeptide binding]; other site
240292014937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292014938	DNA binding site [nucleotide binding]
240292014939	Clp protease ATP binding subunit; Region: clpC; CHL00095
240292014940	Clp amino terminal domain; Region: Clp_N; pfam02861
240292014941	Clp amino terminal domain; Region: Clp_N; pfam02861
240292014942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292014943	Walker A motif; other site
240292014944	ATP binding site [chemical binding]; other site
240292014945	Walker B motif; other site
240292014946	arginine finger; other site
240292014947	UvrB/uvrC motif; Region: UVR; pfam02151
240292014948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292014949	Walker A motif; other site
240292014950	ATP binding site [chemical binding]; other site
240292014951	Walker B motif; other site
240292014952	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240292014953	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
240292014954	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
240292014955	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
240292014956	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
240292014957	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
240292014958	PhoH-like protein; Region: PhoH; pfam02562
240292014959	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
240292014960	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
240292014961	KH domain; Region: KH_4; pfam13083
240292014962	G-X-X-G motif; other site
240292014963	ribosomal protein S16; Region: rps16; CHL00005
240292014964	signal recognition particle protein; Provisional; Region: PRK10867
240292014965	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
240292014966	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
240292014967	GTP binding site [chemical binding]; other site
240292014968	Signal peptide binding domain; Region: SRP_SPB; pfam02978
240292014969	DNA methylase; Region: N6_N4_Mtase; cl17433
240292014970	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
240292014971	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
240292014972	putative ligand binding site [chemical binding]; other site
240292014973	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
240292014974	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
240292014975	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
240292014976	TM-ABC transporter signature motif; other site
240292014977	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
240292014978	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
240292014979	TM-ABC transporter signature motif; other site
240292014980	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
240292014981	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
240292014982	Walker A/P-loop; other site
240292014983	ATP binding site [chemical binding]; other site
240292014984	Q-loop/lid; other site
240292014985	ABC transporter signature motif; other site
240292014986	Walker B; other site
240292014987	D-loop; other site
240292014988	H-loop/switch region; other site
240292014989	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
240292014990	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
240292014991	Walker A/P-loop; other site
240292014992	ATP binding site [chemical binding]; other site
240292014993	Q-loop/lid; other site
240292014994	ABC transporter signature motif; other site
240292014995	Walker B; other site
240292014996	D-loop; other site
240292014997	H-loop/switch region; other site
240292014998	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
240292014999	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
240292015000	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
240292015001	active site
240292015002	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
240292015003	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
240292015004	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240292015005	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240292015006	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292015007	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292015008	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292015009	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240292015010	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240292015011	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240292015012	Phosphotransferase enzyme family; Region: APH; pfam01636
240292015013	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
240292015014	substrate binding site [chemical binding]; other site
240292015015	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
240292015016	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
240292015017	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
240292015018	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240292015019	E3 interaction surface; other site
240292015020	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292015021	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
240292015022	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
240292015023	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
240292015024	putative active site [active]
240292015025	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292015026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292015027	Walker A/P-loop; other site
240292015028	ATP binding site [chemical binding]; other site
240292015029	Q-loop/lid; other site
240292015030	ABC transporter signature motif; other site
240292015031	Walker B; other site
240292015032	D-loop; other site
240292015033	H-loop/switch region; other site
240292015034	Homeodomain-like domain; Region: HTH_23; pfam13384
240292015035	Winged helix-turn helix; Region: HTH_29; pfam13551
240292015036	Winged helix-turn helix; Region: HTH_33; pfam13592
240292015037	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
240292015038	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
240292015039	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
240292015040	active site
240292015041	dimer interface [polypeptide binding]; other site
240292015042	metal binding site [ion binding]; metal-binding site
240292015043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292015044	putative active site [active]
240292015045	Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502
240292015046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292015047	FeS/SAM binding site; other site
240292015048	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
240292015049	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240292015050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292015051	S-adenosylmethionine binding site [chemical binding]; other site
240292015052	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292015053	active site
240292015054	ATP binding site [chemical binding]; other site
240292015055	substrate binding site [chemical binding]; other site
240292015056	activation loop (A-loop); other site
240292015057	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
240292015058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292015059	FeS/SAM binding site; other site
240292015060	HemN C-terminal domain; Region: HemN_C; pfam06969
240292015061	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
240292015062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292015063	active site
240292015064	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240292015065	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240292015066	active site
240292015067	metal binding site [ion binding]; metal-binding site
240292015068	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292015069	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292015070	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292015071	arogenate dehydrogenase; Reviewed; Region: PRK07417
240292015072	prephenate dehydrogenase; Validated; Region: PRK08507
240292015073	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292015074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015079	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015081	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292015082	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
240292015083	PAS domain S-box; Region: sensory_box; TIGR00229
240292015084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015085	putative active site [active]
240292015086	heme pocket [chemical binding]; other site
240292015087	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015088	GAF domain; Region: GAF; pfam01590
240292015089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015090	dimer interface [polypeptide binding]; other site
240292015091	phosphorylation site [posttranslational modification]
240292015092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015093	ATP binding site [chemical binding]; other site
240292015094	Mg2+ binding site [ion binding]; other site
240292015095	G-X-G motif; other site
240292015096	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240292015097	G1 box; other site
240292015098	GTP/Mg2+ binding site [chemical binding]; other site
240292015099	G2 box; other site
240292015100	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240292015101	Predicted integral membrane protein [Function unknown]; Region: COG5500
240292015102	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
240292015103	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
240292015104	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
240292015105	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
240292015106	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
240292015107	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
240292015108	catalytic motif [active]
240292015109	Catalytic residue [active]
240292015110	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
240292015111	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
240292015112	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
240292015113	catalytic site [active]
240292015114	subunit interface [polypeptide binding]; other site
240292015115	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
240292015116	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292015117	anti sigma factor interaction site; other site
240292015118	regulatory phosphorylation site [posttranslational modification]; other site
240292015119	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
240292015120	dimerization interface [polypeptide binding]; other site
240292015121	active site
240292015122	metal binding site [ion binding]; metal-binding site
240292015123	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
240292015124	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
240292015125	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240292015126	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
240292015127	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292015128	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
240292015129	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
240292015130	Uncharacterized conserved protein [Function unknown]; Region: COG3937
240292015131	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
240292015132	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
240292015133	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292015134	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
240292015135	catalytic residue [active]
240292015136	Pirin-related protein [General function prediction only]; Region: COG1741
240292015137	Pirin; Region: Pirin; pfam02678
240292015138	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
240292015139	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
240292015140	dimerization interface [polypeptide binding]; other site
240292015141	DPS ferroxidase diiron center [ion binding]; other site
240292015142	ion pore; other site
240292015143	Rubrerythrin [Energy production and conversion]; Region: COG1592
240292015144	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
240292015145	binuclear metal center [ion binding]; other site
240292015146	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
240292015147	iron binding site [ion binding]; other site
240292015148	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292015149	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292015150	phosphopeptide binding site; other site
240292015151	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015152	GAF domain; Region: GAF; pfam01590
240292015153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240292015154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240292015155	metal binding site [ion binding]; metal-binding site
240292015156	active site
240292015157	I-site; other site
240292015158	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240292015159	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
240292015160	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
240292015161	Surface antigen; Region: Bac_surface_Ag; pfam01103
240292015162	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
240292015163	Prostaglandin dehydrogenases; Region: PGDH; cd05288
240292015164	NAD(P) binding site [chemical binding]; other site
240292015165	substrate binding site [chemical binding]; other site
240292015166	dimer interface [polypeptide binding]; other site
240292015167	16S rRNA methyltransferase B; Provisional; Region: PRK14901
240292015168	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
240292015169	putative RNA binding site [nucleotide binding]; other site
240292015170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292015171	S-adenosylmethionine binding site [chemical binding]; other site
240292015172	tellurium resistance terB-like protein; Region: terB_like; cd07177
240292015173	metal binding site [ion binding]; metal-binding site
240292015174	Response regulator receiver domain; Region: Response_reg; pfam00072
240292015175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015176	active site
240292015177	phosphorylation site [posttranslational modification]
240292015178	intermolecular recognition site; other site
240292015179	dimerization interface [polypeptide binding]; other site
240292015180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015181	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292015182	putative active site [active]
240292015183	heme pocket [chemical binding]; other site
240292015184	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292015185	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015186	putative active site [active]
240292015187	heme pocket [chemical binding]; other site
240292015188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015189	putative active site [active]
240292015190	heme pocket [chemical binding]; other site
240292015191	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292015192	PAS domain; Region: PAS; smart00091
240292015193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015194	dimer interface [polypeptide binding]; other site
240292015195	phosphorylation site [posttranslational modification]
240292015196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015197	ATP binding site [chemical binding]; other site
240292015198	Mg2+ binding site [ion binding]; other site
240292015199	G-X-G motif; other site
240292015200	Response regulator receiver domain; Region: Response_reg; pfam00072
240292015201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015202	active site
240292015203	phosphorylation site [posttranslational modification]
240292015204	intermolecular recognition site; other site
240292015205	dimerization interface [polypeptide binding]; other site
240292015206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292015207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015208	phosphorylation site [posttranslational modification]
240292015209	GAF domain; Region: GAF_2; pfam13185
240292015210	GAF domain; Region: GAF_3; pfam13492
240292015211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015212	ATP binding site [chemical binding]; other site
240292015213	Mg2+ binding site [ion binding]; other site
240292015214	G-X-G motif; other site
240292015215	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
240292015216	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
240292015217	active site
240292015218	FMN binding site [chemical binding]; other site
240292015219	substrate binding site [chemical binding]; other site
240292015220	homotetramer interface [polypeptide binding]; other site
240292015221	catalytic residue [active]
240292015222	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
240292015223	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
240292015224	dimer interface [polypeptide binding]; other site
240292015225	putative PBP binding regions; other site
240292015226	ABC-ATPase subunit  interface; other site
240292015227	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292015228	dimerization interface [polypeptide binding]; other site
240292015229	putative DNA binding site [nucleotide binding]; other site
240292015230	putative Zn2+ binding site [ion binding]; other site
240292015231	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
240292015232	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
240292015233	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
240292015234	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
240292015235	metal binding site [ion binding]; metal-binding site
240292015236	S-layer homology domain; Region: SLH; pfam00395
240292015237	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240292015238	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
240292015239	putative active site pocket [active]
240292015240	dimerization interface [polypeptide binding]; other site
240292015241	putative catalytic residue [active]
240292015242	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
240292015243	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
240292015244	active site
240292015245	Zn binding site [ion binding]; other site
240292015246	AAA ATPase domain; Region: AAA_16; pfam13191
240292015247	AAA ATPase domain; Region: AAA_16; pfam13191
240292015248	AAA domain; Region: AAA_22; pfam13401
240292015249	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
240292015250	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
240292015251	putative active site [active]
240292015252	catalytic residue [active]
240292015253	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
240292015254	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
240292015255	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
240292015256	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
240292015257	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
240292015258	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
240292015259	active site
240292015260	catalytic site [active]
240292015261	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
240292015262	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292015263	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240292015264	putative acyl-acceptor binding pocket; other site
240292015265	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
240292015266	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292015267	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
240292015268	putative hydrophobic ligand binding site [chemical binding]; other site
240292015269	GAF domain; Region: GAF; pfam01590
240292015270	GAF domain; Region: GAF; pfam01590
240292015271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292015272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015273	dimer interface [polypeptide binding]; other site
240292015274	phosphorylation site [posttranslational modification]
240292015275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015276	ATP binding site [chemical binding]; other site
240292015277	Mg2+ binding site [ion binding]; other site
240292015278	G-X-G motif; other site
240292015279	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292015280	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292015281	active site
240292015282	Tic20-like protein; Region: Tic20; pfam09685
240292015283	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
240292015284	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
240292015285	putative active site [active]
240292015286	catalytic triad [active]
240292015287	putative dimer interface [polypeptide binding]; other site
240292015288	DNA gyrase subunit A; Validated; Region: PRK05560
240292015289	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
240292015290	CAP-like domain; other site
240292015291	active site
240292015292	primary dimer interface [polypeptide binding]; other site
240292015293	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015294	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015295	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015296	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015297	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015298	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240292015299	conserved hypothetical protein; Region: TIGR02231
240292015300	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
240292015301	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
240292015302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240292015303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292015304	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
240292015305	putative dimerization interface [polypeptide binding]; other site
240292015306	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292015307	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292015308	Hexamer interface [polypeptide binding]; other site
240292015309	Hexagonal pore residue; other site
240292015310	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292015311	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292015312	Hexamer interface [polypeptide binding]; other site
240292015313	Hexagonal pore residue; other site
240292015314	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
240292015315	putative trimer interface [polypeptide binding]; other site
240292015316	putative CoA binding site [chemical binding]; other site
240292015317	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
240292015318	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
240292015319	trimer interface [polypeptide binding]; other site
240292015320	active site
240292015321	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
240292015322	putative multimerization interface [polypeptide binding]; other site
240292015323	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
240292015324	putative multimerization interface [polypeptide binding]; other site
240292015325	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
240292015326	putative multimerization interface [polypeptide binding]; other site
240292015327	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
240292015328	Hexamer/Pentamer interface [polypeptide binding]; other site
240292015329	central pore; other site
240292015330	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292015331	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292015332	Hexamer interface [polypeptide binding]; other site
240292015333	Hexagonal pore residue; other site
240292015334	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292015335	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292015336	Hexamer interface [polypeptide binding]; other site
240292015337	Hexagonal pore residue; other site
240292015338	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
240292015339	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292015340	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
240292015341	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292015342	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
240292015343	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
240292015344	A new structural DNA glycosylase; Region: AlkD_like; cl11434
240292015345	HEAT repeats; Region: HEAT_2; pfam13646
240292015346	HEAT repeats; Region: HEAT_2; pfam13646
240292015347	nitrogenase reductase; Reviewed; Region: PRK13236
240292015348	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
240292015349	Nucleotide-binding sites [chemical binding]; other site
240292015350	Walker A motif; other site
240292015351	Switch I region of nucleotide binding site; other site
240292015352	Fe4S4 binding sites [ion binding]; other site
240292015353	Switch II region of nucleotide binding site; other site
240292015354	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
240292015355	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
240292015356	glycogen binding site [chemical binding]; other site
240292015357	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
240292015358	active site
240292015359	catalytic site [active]
240292015360	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
240292015361	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
240292015362	acylphosphatase; Provisional; Region: PRK14423
240292015363	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
240292015364	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
240292015365	putative NAD(P) binding site [chemical binding]; other site
240292015366	putative substrate binding site [chemical binding]; other site
240292015367	catalytic Zn binding site [ion binding]; other site
240292015368	structural Zn binding site [ion binding]; other site
240292015369	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
240292015370	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
240292015371	active site
240292015372	Zn binding site [ion binding]; other site
240292015373	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
240292015374	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292015375	Ligand Binding Site [chemical binding]; other site
240292015376	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292015377	Ligand Binding Site [chemical binding]; other site
240292015378	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
240292015379	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240292015380	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240292015381	catalytic loop [active]
240292015382	iron binding site [ion binding]; other site
240292015383	Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533
240292015384	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292015385	active site
240292015386	ATP binding site [chemical binding]; other site
240292015387	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292015388	substrate binding site [chemical binding]; other site
240292015389	activation loop (A-loop); other site
240292015390	AAA ATPase domain; Region: AAA_16; pfam13191
240292015391	Predicted ATPase [General function prediction only]; Region: COG3899
240292015392	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015393	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292015394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015395	dimer interface [polypeptide binding]; other site
240292015396	phosphorylation site [posttranslational modification]
240292015397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015398	ATP binding site [chemical binding]; other site
240292015399	Mg2+ binding site [ion binding]; other site
240292015400	G-X-G motif; other site
240292015401	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
240292015402	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
240292015403	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240292015404	active site
240292015405	dimer interface [polypeptide binding]; other site
240292015406	TPR repeat; Region: TPR_11; pfam13414
240292015407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015408	binding surface
240292015409	TPR motif; other site
240292015410	TPR repeat; Region: TPR_11; pfam13414
240292015411	TPR repeat; Region: TPR_11; pfam13414
240292015412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015413	binding surface
240292015414	TPR motif; other site
240292015415	TPR repeat; Region: TPR_11; pfam13414
240292015416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015417	binding surface
240292015418	TPR motif; other site
240292015419	TPR repeat; Region: TPR_11; pfam13414
240292015420	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015421	binding surface
240292015422	TPR motif; other site
240292015423	TPR repeat; Region: TPR_11; pfam13414
240292015424	TPR repeat; Region: TPR_11; pfam13414
240292015425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015426	binding surface
240292015427	TPR motif; other site
240292015428	TPR repeat; Region: TPR_11; pfam13414
240292015429	Uncharacterized conserved protein [Function unknown]; Region: COG5502
240292015430	intracellular protease, PfpI family; Region: PfpI; TIGR01382
240292015431	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
240292015432	proposed catalytic triad [active]
240292015433	conserved cys residue [active]
240292015434	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
240292015435	dinuclear metal binding motif [ion binding]; other site
240292015436	Predicted integral membrane protein [Function unknown]; Region: COG5637
240292015437	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
240292015438	putative hydrophobic ligand binding site [chemical binding]; other site
240292015439	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
240292015440	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292015441	NAD binding site [chemical binding]; other site
240292015442	catalytic Zn binding site [ion binding]; other site
240292015443	structural Zn binding site [ion binding]; other site
240292015444	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
240292015445	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240292015446	NAD binding site [chemical binding]; other site
240292015447	catalytic Zn binding site [ion binding]; other site
240292015448	structural Zn binding site [ion binding]; other site
240292015449	Cupin domain; Region: Cupin_2; pfam07883
240292015450	Protein kinase domain; Region: Pkinase; pfam00069
240292015451	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292015452	active site
240292015453	ATP binding site [chemical binding]; other site
240292015454	substrate binding site [chemical binding]; other site
240292015455	activation loop (A-loop); other site
240292015456	AAA ATPase domain; Region: AAA_16; pfam13191
240292015457	Predicted ATPase [General function prediction only]; Region: COG3899
240292015458	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015459	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292015460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292015461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015462	dimer interface [polypeptide binding]; other site
240292015463	phosphorylation site [posttranslational modification]
240292015464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015465	ATP binding site [chemical binding]; other site
240292015466	Mg2+ binding site [ion binding]; other site
240292015467	G-X-G motif; other site
240292015468	Protein kinase domain; Region: Pkinase; pfam00069
240292015469	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292015470	active site
240292015471	ATP binding site [chemical binding]; other site
240292015472	substrate binding site [chemical binding]; other site
240292015473	activation loop (A-loop); other site
240292015474	AAA ATPase domain; Region: AAA_16; pfam13191
240292015475	Predicted ATPase [General function prediction only]; Region: COG3899
240292015476	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015477	GAF domain; Region: GAF; pfam01590
240292015478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292015479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015480	ATP binding site [chemical binding]; other site
240292015481	Mg2+ binding site [ion binding]; other site
240292015482	G-X-G motif; other site
240292015483	Uncharacterized conserved protein [Function unknown]; Region: COG1801
240292015484	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
240292015485	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292015486	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
240292015487	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
240292015488	active site residue [active]
240292015489	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
240292015490	active site residue [active]
240292015491	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
240292015492	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
240292015493	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
240292015494	Dynamin family; Region: Dynamin_N; pfam00350
240292015495	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
240292015496	G1 box; other site
240292015497	GTP/Mg2+ binding site [chemical binding]; other site
240292015498	Switch I region; other site
240292015499	G2 box; other site
240292015500	Switch II region; other site
240292015501	G3 box; other site
240292015502	G4 box; other site
240292015503	G5 box; other site
240292015504	Domain of unknown function (DUF697); Region: DUF697; pfam05128
240292015505	CP12 domain; Region: CP12; pfam02672
240292015506	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
240292015507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292015508	RNA binding surface [nucleotide binding]; other site
240292015509	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
240292015510	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258
240292015511	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240292015512	Walker A/P-loop; other site
240292015513	ATP binding site [chemical binding]; other site
240292015514	Q-loop/lid; other site
240292015515	ABC transporter signature motif; other site
240292015516	Walker B; other site
240292015517	D-loop; other site
240292015518	H-loop/switch region; other site
240292015519	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14260
240292015520	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240292015521	Walker A/P-loop; other site
240292015522	ATP binding site [chemical binding]; other site
240292015523	Q-loop/lid; other site
240292015524	ABC transporter signature motif; other site
240292015525	Walker B; other site
240292015526	D-loop; other site
240292015527	H-loop/switch region; other site
240292015528	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
240292015529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292015530	dimer interface [polypeptide binding]; other site
240292015531	conserved gate region; other site
240292015532	putative PBP binding loops; other site
240292015533	ABC-ATPase subunit interface; other site
240292015534	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
240292015535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292015536	dimer interface [polypeptide binding]; other site
240292015537	conserved gate region; other site
240292015538	putative PBP binding loops; other site
240292015539	ABC-ATPase subunit interface; other site
240292015540	PBP superfamily domain; Region: PBP_like_2; cl17296
240292015541	GTPase Era; Reviewed; Region: era; PRK00089
240292015542	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
240292015543	G1 box; other site
240292015544	GTP/Mg2+ binding site [chemical binding]; other site
240292015545	Switch I region; other site
240292015546	G2 box; other site
240292015547	Switch II region; other site
240292015548	G3 box; other site
240292015549	G4 box; other site
240292015550	G5 box; other site
240292015551	KH domain; Region: KH_2; pfam07650
240292015552	Response regulator receiver domain; Region: Response_reg; pfam00072
240292015553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015554	active site
240292015555	phosphorylation site [posttranslational modification]
240292015556	intermolecular recognition site; other site
240292015557	dimerization interface [polypeptide binding]; other site
240292015558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240292015559	DNA binding residues [nucleotide binding]
240292015560	Transposase IS200 like; Region: Y1_Tnp; pfam01797
240292015561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292015562	Probable transposase; Region: OrfB_IS605; pfam01385
240292015563	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292015564	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
240292015565	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
240292015566	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
240292015567	iron-sulfur cluster [ion binding]; other site
240292015568	[2Fe-2S] cluster binding site [ion binding]; other site
240292015569	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
240292015570	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
240292015571	Amidase; Region: Amidase; pfam01425
240292015572	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240292015573	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
240292015574	putative acyl-acceptor binding pocket; other site
240292015575	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
240292015576	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
240292015577	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
240292015578	dimer interface [polypeptide binding]; other site
240292015579	[2Fe-2S] cluster binding site [ion binding]; other site
240292015580	S-layer homology domain; Region: SLH; pfam00395
240292015581	S-layer homology domain; Region: SLH; pfam00395
240292015582	S-layer homology domain; Region: SLH; pfam00395
240292015583	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
240292015584	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
240292015585	TPP-binding site; other site
240292015586	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
240292015587	PYR/PP interface [polypeptide binding]; other site
240292015588	dimer interface [polypeptide binding]; other site
240292015589	TPP binding site [chemical binding]; other site
240292015590	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240292015591	hypothetical protein; Provisional; Region: PRK07394
240292015592	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
240292015593	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
240292015594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240292015595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292015596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
240292015597	dimerization interface [polypeptide binding]; other site
240292015598	S-layer homology domain; Region: SLH; pfam00395
240292015599	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
240292015600	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
240292015601	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
240292015602	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
240292015603	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
240292015604	iron-sulfur cluster [ion binding]; other site
240292015605	[2Fe-2S] cluster binding site [ion binding]; other site
240292015606	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
240292015607	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292015608	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292015609	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292015610	NMT1-like family; Region: NMT1_2; pfam13379
240292015611	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292015612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292015613	dimer interface [polypeptide binding]; other site
240292015614	conserved gate region; other site
240292015615	putative PBP binding loops; other site
240292015616	ABC-ATPase subunit interface; other site
240292015617	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292015618	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
240292015619	Walker A/P-loop; other site
240292015620	ATP binding site [chemical binding]; other site
240292015621	Q-loop/lid; other site
240292015622	ABC transporter signature motif; other site
240292015623	Walker B; other site
240292015624	D-loop; other site
240292015625	H-loop/switch region; other site
240292015626	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
240292015627	NMT1-like family; Region: NMT1_2; pfam13379
240292015628	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240292015629	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
240292015630	Walker A/P-loop; other site
240292015631	ATP binding site [chemical binding]; other site
240292015632	Q-loop/lid; other site
240292015633	ABC transporter signature motif; other site
240292015634	Walker B; other site
240292015635	D-loop; other site
240292015636	H-loop/switch region; other site
240292015637	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
240292015638	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
240292015639	[4Fe-4S] binding site [ion binding]; other site
240292015640	molybdopterin cofactor binding site; other site
240292015641	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
240292015642	molybdopterin cofactor binding site; other site
240292015643	Predicted membrane protein [Function unknown]; Region: COG3431
240292015644	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
240292015645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
240292015646	HEAT repeats; Region: HEAT_2; pfam13646
240292015647	HEAT repeats; Region: HEAT_2; pfam13646
240292015648	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
240292015649	CpeS-like protein; Region: CpeS; pfam09367
240292015650	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240292015651	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240292015652	ligand binding site [chemical binding]; other site
240292015653	flexible hinge region; other site
240292015654	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
240292015655	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
240292015656	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292015657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292015658	S-adenosylmethionine binding site [chemical binding]; other site
240292015659	TPR repeat; Region: TPR_11; pfam13414
240292015660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015661	binding surface
240292015662	TPR motif; other site
240292015663	TPR repeat; Region: TPR_11; pfam13414
240292015664	TPR repeat; Region: TPR_11; pfam13414
240292015665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292015666	binding surface
240292015667	TPR motif; other site
240292015668	TPR repeat; Region: TPR_11; pfam13414
240292015669	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
240292015670	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
240292015671	Cysteine-rich domain; Region: CCG; pfam02754
240292015672	Cysteine-rich domain; Region: CCG; pfam02754
240292015673	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
240292015674	FAD binding domain; Region: FAD_binding_4; pfam01565
240292015675	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292015676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292015677	S-adenosylmethionine binding site [chemical binding]; other site
240292015678	calcium/proton exchanger (cax); Region: cax; TIGR00378
240292015679	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
240292015680	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
240292015681	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
240292015682	active site
240292015683	catalytic site [active]
240292015684	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
240292015685	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240292015686	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240292015687	active site
240292015688	KGK domain; Region: KGK; pfam08872
240292015689	KGK domain; Region: KGK; pfam08872
240292015690	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
240292015691	Transposase domain (DUF772); Region: DUF772; pfam05598
240292015692	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292015693	Ligand Binding Site [chemical binding]; other site
240292015694	phosphoenolpyruvate synthase; Validated; Region: PRK06464
240292015695	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
240292015696	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
240292015697	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
240292015698	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
240292015699	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292015700	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
240292015701	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240292015702	Walker A/P-loop; other site
240292015703	ATP binding site [chemical binding]; other site
240292015704	Q-loop/lid; other site
240292015705	ABC transporter signature motif; other site
240292015706	Walker B; other site
240292015707	D-loop; other site
240292015708	H-loop/switch region; other site
240292015709	Uncharacterized conserved protein [Function unknown]; Region: COG3339
240292015710	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
240292015711	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
240292015712	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
240292015713	Predicted membrane protein [Function unknown]; Region: COG1950
240292015714	Thf1-like protein; Reviewed; Region: PRK13266
240292015715	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
240292015716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292015717	Probable transposase; Region: OrfB_IS605; pfam01385
240292015718	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292015719	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
240292015720	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240292015721	anti sigma factor interaction site; other site
240292015722	regulatory phosphorylation site [posttranslational modification]; other site
240292015723	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
240292015724	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
240292015725	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
240292015726	hydrophobic ligand binding site; other site
240292015727	Domain of unknown function DUF59; Region: DUF59; pfam01883
240292015728	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
240292015729	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
240292015730	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
240292015731	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
240292015732	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240292015733	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240292015734	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
240292015735	Ligand Binding Site [chemical binding]; other site
240292015736	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292015737	Ligand Binding Site [chemical binding]; other site
240292015738	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240292015739	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
240292015740	NAD binding site [chemical binding]; other site
240292015741	putative substrate binding site 2 [chemical binding]; other site
240292015742	putative substrate binding site 1 [chemical binding]; other site
240292015743	active site
240292015744	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
240292015745	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
240292015746	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
240292015747	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
240292015748	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
240292015749	putative deacylase active site [active]
240292015750	Protein of unknown function (DUF433); Region: DUF433; pfam04255
240292015751	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
240292015752	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
240292015753	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
240292015754	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
240292015755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292015756	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
240292015757	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
240292015758	Acylphosphatase; Region: Acylphosphatase; pfam00708
240292015759	HypF finger; Region: zf-HYPF; pfam07503
240292015760	HypF finger; Region: zf-HYPF; pfam07503
240292015761	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
240292015762	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
240292015763	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
240292015764	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
240292015765	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
240292015766	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
240292015767	active site 1 [active]
240292015768	dimer interface [polypeptide binding]; other site
240292015769	hexamer interface [polypeptide binding]; other site
240292015770	active site 2 [active]
240292015771	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
240292015772	dimerization interface [polypeptide binding]; other site
240292015773	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
240292015774	ATP binding site [chemical binding]; other site
240292015775	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
240292015776	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
240292015777	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292015778	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
240292015779	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292015780	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240292015781	protein binding site [polypeptide binding]; other site
240292015782	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240292015783	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
240292015784	Homeodomain-like domain; Region: HTH_23; pfam13384
240292015785	Winged helix-turn helix; Region: HTH_29; pfam13551
240292015786	Winged helix-turn helix; Region: HTH_33; pfam13592
240292015787	DDE superfamily endonuclease; Region: DDE_3; pfam13358
240292015788	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
240292015789	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240292015790	nucleotide binding site [chemical binding]; other site
240292015791	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240292015792	nucleotide binding site [chemical binding]; other site
240292015793	glycogen branching enzyme; Provisional; Region: PRK05402
240292015794	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
240292015795	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
240292015796	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
240292015797	active site
240292015798	catalytic site [active]
240292015799	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
240292015800	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
240292015801	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
240292015802	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240292015803	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
240292015804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240292015805	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
240292015806	GTP-binding protein YchF; Reviewed; Region: PRK09601
240292015807	YchF GTPase; Region: YchF; cd01900
240292015808	G1 box; other site
240292015809	GTP/Mg2+ binding site [chemical binding]; other site
240292015810	Switch I region; other site
240292015811	G2 box; other site
240292015812	Switch II region; other site
240292015813	G3 box; other site
240292015814	G4 box; other site
240292015815	G5 box; other site
240292015816	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
240292015817	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240292015818	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
240292015819	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
240292015820	active site
240292015821	trimer interface [polypeptide binding]; other site
240292015822	allosteric site; other site
240292015823	active site lid [active]
240292015824	hexamer (dimer of trimers) interface [polypeptide binding]; other site
240292015825	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
240292015826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292015827	active site
240292015828	motif I; other site
240292015829	motif II; other site
240292015830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
240292015831	active site
240292015832	phosphorylation site [posttranslational modification]
240292015833	intermolecular recognition site; other site
240292015834	dimerization interface [polypeptide binding]; other site
240292015835	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015836	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292015837	PAS domain S-box; Region: sensory_box; TIGR00229
240292015838	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015839	putative active site [active]
240292015840	heme pocket [chemical binding]; other site
240292015841	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015842	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292015843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292015844	PAS fold; Region: PAS_3; pfam08447
240292015845	putative active site [active]
240292015846	heme pocket [chemical binding]; other site
240292015847	PAS fold; Region: PAS_4; pfam08448
240292015848	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015849	GAF domain; Region: GAF; pfam01590
240292015850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292015851	dimer interface [polypeptide binding]; other site
240292015852	phosphorylation site [posttranslational modification]
240292015853	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
240292015854	Mg2+ binding site [ion binding]; other site
240292015855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292015856	ATP binding site [chemical binding]; other site
240292015857	G-X-G motif; other site
240292015858	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292015859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015860	active site
240292015861	phosphorylation site [posttranslational modification]
240292015862	intermolecular recognition site; other site
240292015863	dimerization interface [polypeptide binding]; other site
240292015864	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
240292015865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240292015866	FeS/SAM binding site; other site
240292015867	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
240292015868	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
240292015869	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
240292015870	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
240292015871	dimer interface [polypeptide binding]; other site
240292015872	catalytic residues [active]
240292015873	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
240292015874	UreF; Region: UreF; pfam01730
240292015875	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292015876	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
240292015877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292015878	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
240292015879	catalytic residues [active]
240292015880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292015881	dimer interface [polypeptide binding]; other site
240292015882	conserved gate region; other site
240292015883	putative PBP binding loops; other site
240292015884	ABC-ATPase subunit interface; other site
240292015885	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
240292015886	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
240292015887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
240292015888	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
240292015889	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240292015890	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
240292015891	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
240292015892	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
240292015893	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
240292015894	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
240292015895	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292015896	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292015897	phosphopeptide binding site; other site
240292015898	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292015899	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292015900	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240292015901	cyclase homology domain; Region: CHD; cd07302
240292015902	nucleotidyl binding site; other site
240292015903	metal binding site [ion binding]; metal-binding site
240292015904	dimer interface [polypeptide binding]; other site
240292015905	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
240292015906	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
240292015907	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
240292015908	GTP/Mg2+ binding site [chemical binding]; other site
240292015909	G4 box; other site
240292015910	G5 box; other site
240292015911	G1 box; other site
240292015912	Switch I region; other site
240292015913	G2 box; other site
240292015914	G3 box; other site
240292015915	Switch II region; other site
240292015916	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240292015917	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240292015918	active site
240292015919	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
240292015920	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
240292015921	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
240292015922	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
240292015923	16S/18S rRNA binding site [nucleotide binding]; other site
240292015924	S13e-L30e interaction site [polypeptide binding]; other site
240292015925	25S rRNA binding site [nucleotide binding]; other site
240292015926	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292015927	Ligand Binding Site [chemical binding]; other site
240292015928	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
240292015929	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
240292015930	putative dimer interface [polypeptide binding]; other site
240292015931	[2Fe-2S] cluster binding site [ion binding]; other site
240292015932	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
240292015933	dimer interface [polypeptide binding]; other site
240292015934	[2Fe-2S] cluster binding site [ion binding]; other site
240292015935	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
240292015936	SLBB domain; Region: SLBB; pfam10531
240292015937	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
240292015938	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
240292015939	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
240292015940	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
240292015941	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
240292015942	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
240292015943	4Fe-4S binding domain; Region: Fer4; pfam00037
240292015944	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
240292015945	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
240292015946	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
240292015947	FOG: CBS domain [General function prediction only]; Region: COG0517
240292015948	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
240292015949	CP12 domain; Region: CP12; pfam02672
240292015950	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
240292015951	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
240292015952	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
240292015953	homotrimer interaction site [polypeptide binding]; other site
240292015954	putative active site [active]
240292015955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292015956	Coenzyme A binding pocket [chemical binding]; other site
240292015957	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
240292015958	CoA binding domain; Region: CoA_binding_2; pfam13380
240292015959	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
240292015960	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
240292015961	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240292015962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292015963	Coenzyme A binding pocket [chemical binding]; other site
240292015964	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
240292015965	nickel binding site [ion binding]; other site
240292015966	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
240292015967	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
240292015968	dimer interface [polypeptide binding]; other site
240292015969	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
240292015970	active site
240292015971	Fe binding site [ion binding]; other site
240292015972	classical (c) SDRs; Region: SDR_c; cd05233
240292015973	NAD(P) binding site [chemical binding]; other site
240292015974	active site
240292015975	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240292015976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292015977	S-adenosylmethionine binding site [chemical binding]; other site
240292015978	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
240292015979	Response regulator receiver domain; Region: Response_reg; pfam00072
240292015980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292015981	active site
240292015982	phosphorylation site [posttranslational modification]
240292015983	intermolecular recognition site; other site
240292015984	dimerization interface [polypeptide binding]; other site
240292015985	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
240292015986	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
240292015987	Active site cavity [active]
240292015988	catalytic acid [active]
240292015989	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
240292015990	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
240292015991	DXD motif; other site
240292015992	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292015993	serpin-like protein; Provisional; Region: PHA02660
240292015994	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
240292015995	reactive center loop; other site
240292015996	Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488
240292015997	putative catalytic residues [active]
240292015998	putative active site [active]
240292015999	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
240292016000	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
240292016001	substrate binding site [chemical binding]; other site
240292016002	hexamer interface [polypeptide binding]; other site
240292016003	metal binding site [ion binding]; metal-binding site
240292016004	CsbD-like; Region: CsbD; pfam05532
240292016005	excinuclease ABC subunit B; Provisional; Region: PRK05298
240292016006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240292016007	ATP binding site [chemical binding]; other site
240292016008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240292016009	nucleotide binding region [chemical binding]; other site
240292016010	ATP-binding site [chemical binding]; other site
240292016011	Ultra-violet resistance protein B; Region: UvrB; pfam12344
240292016012	UvrB/uvrC motif; Region: UVR; pfam02151
240292016013	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016014	active site
240292016015	ATP binding site [chemical binding]; other site
240292016016	substrate binding site [chemical binding]; other site
240292016017	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292016018	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240292016019	activation loop (A-loop); other site
240292016020	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292016021	structural tetrad; other site
240292016022	PQQ-like domain; Region: PQQ_2; pfam13360
240292016023	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
240292016024	EF-hand domain pair; Region: EF_hand_5; pfam13499
240292016025	Ca2+ binding site [ion binding]; other site
240292016026	PRC-barrel domain; Region: PRC; pfam05239
240292016027	PRC-barrel domain; Region: PRC; pfam05239
240292016028	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
240292016029	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
240292016030	Walker A/P-loop; other site
240292016031	ATP binding site [chemical binding]; other site
240292016032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292016033	Q-loop/lid; other site
240292016034	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
240292016035	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
240292016036	ABC transporter signature motif; other site
240292016037	Walker B; other site
240292016038	D-loop; other site
240292016039	H-loop/switch region; other site
240292016040	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292016041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292016042	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292016043	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292016044	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
240292016045	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
240292016046	C-terminal domain interface [polypeptide binding]; other site
240292016047	GSH binding site (G-site) [chemical binding]; other site
240292016048	dimer interface [polypeptide binding]; other site
240292016049	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
240292016050	N-terminal domain interface [polypeptide binding]; other site
240292016051	putative dimer interface [polypeptide binding]; other site
240292016052	active site
240292016053	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
240292016054	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240292016055	Ligand Binding Site [chemical binding]; other site
240292016056	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
240292016057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016058	dimerization interface [polypeptide binding]; other site
240292016059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016060	dimerization interface [polypeptide binding]; other site
240292016061	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016062	dimerization interface [polypeptide binding]; other site
240292016063	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
240292016064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016065	dimerization interface [polypeptide binding]; other site
240292016066	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016067	dimerization interface [polypeptide binding]; other site
240292016068	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
240292016069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016070	dimerization interface [polypeptide binding]; other site
240292016071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016072	dimerization interface [polypeptide binding]; other site
240292016073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016074	dimerization interface [polypeptide binding]; other site
240292016075	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016076	dimerization interface [polypeptide binding]; other site
240292016077	GAF domain; Region: GAF_2; pfam13185
240292016078	GAF domain; Region: GAF; pfam01590
240292016079	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016080	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016081	dimer interface [polypeptide binding]; other site
240292016082	phosphorylation site [posttranslational modification]
240292016083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016084	ATP binding site [chemical binding]; other site
240292016085	Mg2+ binding site [ion binding]; other site
240292016086	G-X-G motif; other site
240292016087	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016089	active site
240292016090	phosphorylation site [posttranslational modification]
240292016091	intermolecular recognition site; other site
240292016092	dimerization interface [polypeptide binding]; other site
240292016093	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016095	active site
240292016096	phosphorylation site [posttranslational modification]
240292016097	intermolecular recognition site; other site
240292016098	dimerization interface [polypeptide binding]; other site
240292016099	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016101	active site
240292016102	phosphorylation site [posttranslational modification]
240292016103	intermolecular recognition site; other site
240292016104	dimerization interface [polypeptide binding]; other site
240292016105	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
240292016106	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292016107	CHASE2 domain; Region: CHASE2; pfam05226
240292016108	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240292016109	cyclase homology domain; Region: CHD; cd07302
240292016110	nucleotidyl binding site; other site
240292016111	metal binding site [ion binding]; metal-binding site
240292016112	dimer interface [polypeptide binding]; other site
240292016113	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292016114	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
240292016115	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240292016116	active site
240292016117	FOG: CBS domain [General function prediction only]; Region: COG0517
240292016118	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
240292016119	FOG: CBS domain [General function prediction only]; Region: COG0517
240292016120	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
240292016121	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292016122	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292016123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016124	PAS fold; Region: PAS_3; pfam08447
240292016125	putative active site [active]
240292016126	heme pocket [chemical binding]; other site
240292016127	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292016128	GAF domain; Region: GAF; pfam01590
240292016129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016131	dimer interface [polypeptide binding]; other site
240292016132	phosphorylation site [posttranslational modification]
240292016133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016134	ATP binding site [chemical binding]; other site
240292016135	Mg2+ binding site [ion binding]; other site
240292016136	G-X-G motif; other site
240292016137	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016139	active site
240292016140	phosphorylation site [posttranslational modification]
240292016141	intermolecular recognition site; other site
240292016142	dimerization interface [polypeptide binding]; other site
240292016143	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016145	active site
240292016146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016147	phosphorylation site [posttranslational modification]
240292016148	intermolecular recognition site; other site
240292016149	dimerization interface [polypeptide binding]; other site
240292016150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016151	dimer interface [polypeptide binding]; other site
240292016152	phosphorylation site [posttranslational modification]
240292016153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016154	ATP binding site [chemical binding]; other site
240292016155	Mg2+ binding site [ion binding]; other site
240292016156	G-X-G motif; other site
240292016157	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
240292016158	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292016159	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292016160	P-loop; other site
240292016161	Magnesium ion binding site [ion binding]; other site
240292016162	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292016163	Magnesium ion binding site [ion binding]; other site
240292016164	Double zinc ribbon; Region: DZR; pfam12773
240292016165	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
240292016166	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
240292016167	dimer interface [polypeptide binding]; other site
240292016168	tetramer interface [polypeptide binding]; other site
240292016169	PYR/PP interface [polypeptide binding]; other site
240292016170	TPP binding site [chemical binding]; other site
240292016171	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
240292016172	TPP-binding site; other site
240292016173	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292016174	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292016175	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292016176	Hexamer interface [polypeptide binding]; other site
240292016177	Hexagonal pore residue; other site
240292016178	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
240292016179	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
240292016180	Hexamer interface [polypeptide binding]; other site
240292016181	Hexagonal pore residue; other site
240292016182	NIL domain; Region: NIL; pfam09383
240292016183	sulfate transport protein; Provisional; Region: cysT; CHL00187
240292016184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292016185	dimer interface [polypeptide binding]; other site
240292016186	conserved gate region; other site
240292016187	putative PBP binding loops; other site
240292016188	ABC-ATPase subunit interface; other site
240292016189	sulfate transport protein; Provisional; Region: cysT; CHL00187
240292016190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292016191	dimer interface [polypeptide binding]; other site
240292016192	conserved gate region; other site
240292016193	putative PBP binding loops; other site
240292016194	ABC-ATPase subunit interface; other site
240292016195	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
240292016196	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292016197	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
240292016198	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240292016199	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016200	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016201	active site
240292016202	ATP binding site [chemical binding]; other site
240292016203	substrate binding site [chemical binding]; other site
240292016204	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240292016205	activation loop (A-loop); other site
240292016206	activation loop (A-loop); other site
240292016207	AAA ATPase domain; Region: AAA_16; pfam13191
240292016208	Predicted ATPase [General function prediction only]; Region: COG3899
240292016209	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016210	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292016211	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240292016212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016213	dimer interface [polypeptide binding]; other site
240292016214	phosphorylation site [posttranslational modification]
240292016215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016216	ATP binding site [chemical binding]; other site
240292016217	Mg2+ binding site [ion binding]; other site
240292016218	G-X-G motif; other site
240292016219	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
240292016220	FAD binding domain; Region: FAD_binding_4; pfam01565
240292016221	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
240292016222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292016223	S-adenosylmethionine binding site [chemical binding]; other site
240292016224	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
240292016225	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
240292016226	putative active site [active]
240292016227	putative dimer interface [polypeptide binding]; other site
240292016228	anthranilate synthase component I; Provisional; Region: PRK13565
240292016229	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
240292016230	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
240292016231	PsaD; Region: PsaD; pfam02531
240292016232	Predicted sensor protein/domain [Signal transduction mechanisms]; Region: COG4250
240292016233	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292016234	GAF domain; Region: GAF; pfam01590
240292016235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016237	dimer interface [polypeptide binding]; other site
240292016238	phosphorylation site [posttranslational modification]
240292016239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016240	ATP binding site [chemical binding]; other site
240292016241	Mg2+ binding site [ion binding]; other site
240292016242	G-X-G motif; other site
240292016243	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
240292016244	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
240292016245	Calx-beta domain; Region: Calx-beta; cl02522
240292016246	Calx-beta domain; Region: Calx-beta; pfam03160
240292016247	Calx-beta domain; Region: Calx-beta; cl02522
240292016248	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292016249	Calx-beta domain; Region: Calx-beta; cl02522
240292016250	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
240292016251	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
240292016252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
240292016253	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
240292016254	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
240292016255	putative active site [active]
240292016256	catalytic site [active]
240292016257	putative metal binding site [ion binding]; other site
240292016258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
240292016259	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292016260	Lamin Tail Domain; Region: LTD; pfam00932
240292016261	Lamin Tail Domain; Region: LTD; pfam00932
240292016262	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
240292016263	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
240292016264	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
240292016265	generic binding surface II; other site
240292016266	generic binding surface I; other site
240292016267	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
240292016268	putative active site [active]
240292016269	putative catalytic site [active]
240292016270	putative Mg binding site IVb [ion binding]; other site
240292016271	putative phosphate binding site [ion binding]; other site
240292016272	putative DNA binding site [nucleotide binding]; other site
240292016273	putative Mg binding site IVa [ion binding]; other site
240292016274	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
240292016275	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
240292016276	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
240292016277	Tubulin like; Region: Tubulin_2; pfam13809
240292016278	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240292016279	metal ion-dependent adhesion site (MIDAS); other site
240292016280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292016281	non-specific DNA binding site [nucleotide binding]; other site
240292016282	salt bridge; other site
240292016283	sequence-specific DNA binding site [nucleotide binding]; other site
240292016284	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240292016285	Protein export membrane protein; Region: SecD_SecF; cl14618
240292016286	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240292016287	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
240292016288	HlyD family secretion protein; Region: HlyD_3; pfam13437
240292016289	PAS fold; Region: PAS; pfam00989
240292016290	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016291	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292016292	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
240292016293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292016294	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292016295	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292016296	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240292016297	active site
240292016298	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292016299	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292016300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292016301	Transposase domain (DUF772); Region: DUF772; pfam05598
240292016302	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292016303	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
240292016304	KR domain; Region: KR; pfam08659
240292016305	putative NADP binding site [chemical binding]; other site
240292016306	active site
240292016307	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240292016308	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
240292016309	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292016310	active site
240292016311	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292016312	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016313	Condensation domain; Region: Condensation; pfam00668
240292016314	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
240292016315	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292016316	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292016317	acyl-activating enzyme (AAE) consensus motif; other site
240292016318	AMP binding site [chemical binding]; other site
240292016319	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
240292016320	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
240292016321	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292016322	active site
240292016323	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292016324	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292016326	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
240292016327	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
240292016328	putative NADP binding site [chemical binding]; other site
240292016329	active site
240292016330	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
240292016331	active site
240292016332	Acyl transferase domain; Region: Acyl_transf_1; cl08282
240292016333	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292016334	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
240292016335	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
240292016336	active site 1 [active]
240292016337	dimer interface [polypeptide binding]; other site
240292016338	active site 2 [active]
240292016339	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
240292016340	active site 1 [active]
240292016341	dimer interface [polypeptide binding]; other site
240292016342	active site 2 [active]
240292016343	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
240292016344	FMN binding site [chemical binding]; other site
240292016345	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
240292016346	substrate binding site [chemical binding]; other site
240292016347	putative catalytic residue [active]
240292016348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292016349	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292016350	putative substrate translocation pore; other site
240292016351	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016353	active site
240292016354	phosphorylation site [posttranslational modification]
240292016355	intermolecular recognition site; other site
240292016356	dimerization interface [polypeptide binding]; other site
240292016357	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240292016358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016359	putative active site [active]
240292016360	heme pocket [chemical binding]; other site
240292016361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016362	dimer interface [polypeptide binding]; other site
240292016363	phosphorylation site [posttranslational modification]
240292016364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016365	ATP binding site [chemical binding]; other site
240292016366	Mg2+ binding site [ion binding]; other site
240292016367	G-X-G motif; other site
240292016368	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016370	active site
240292016371	phosphorylation site [posttranslational modification]
240292016372	intermolecular recognition site; other site
240292016373	dimerization interface [polypeptide binding]; other site
240292016374	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
240292016375	MoaE homodimer interface [polypeptide binding]; other site
240292016376	MoaD interaction [polypeptide binding]; other site
240292016377	active site residues [active]
240292016378	Bacterial SH3 domain; Region: SH3_3; pfam08239
240292016379	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
240292016380	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292016381	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292016382	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292016383	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292016384	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
240292016385	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
240292016386	tetramer interface [polypeptide binding]; other site
240292016387	active site
240292016388	Mg2+/Mn2+ binding site [ion binding]; other site
240292016389	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
240292016390	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
240292016391	putative NAD(P) binding site [chemical binding]; other site
240292016392	active site
240292016393	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
240292016394	dimer interface [polypeptide binding]; other site
240292016395	FMN binding site [chemical binding]; other site
240292016396	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
240292016397	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
240292016398	FMN binding site [chemical binding]; other site
240292016399	active site
240292016400	substrate binding site [chemical binding]; other site
240292016401	catalytic residue [active]
240292016402	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240292016403	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240292016404	catalytic residues [active]
240292016405	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240292016406	dimerization interface [polypeptide binding]; other site
240292016407	putative DNA binding site [nucleotide binding]; other site
240292016408	putative Zn2+ binding site [ion binding]; other site
240292016409	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
240292016410	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
240292016411	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016412	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016413	active site
240292016414	ATP binding site [chemical binding]; other site
240292016415	substrate binding site [chemical binding]; other site
240292016416	activation loop (A-loop); other site
240292016417	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
240292016418	Ycf46; Provisional; Region: ycf46; CHL00195
240292016419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292016420	Walker A motif; other site
240292016421	ATP binding site [chemical binding]; other site
240292016422	Walker B motif; other site
240292016423	arginine finger; other site
240292016424	Transposase domain (DUF772); Region: DUF772; pfam05598
240292016425	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240292016426	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292016427	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240292016428	active site
240292016429	metal binding site [ion binding]; metal-binding site
240292016430	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240292016431	putative lipid kinase; Reviewed; Region: PRK00861
240292016432	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
240292016433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
240292016434	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
240292016435	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
240292016436	domain interfaces; other site
240292016437	active site
240292016438	glycogen synthase; Provisional; Region: glgA; PRK00654
240292016439	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
240292016440	ADP-binding pocket [chemical binding]; other site
240292016441	homodimer interface [polypeptide binding]; other site
240292016442	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
240292016443	diiron binding motif [ion binding]; other site
240292016444	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
240292016445	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240292016446	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
240292016447	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240292016448	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
240292016449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240292016450	dimerization interface [polypeptide binding]; other site
240292016451	GAF domain; Region: GAF; pfam01590
240292016452	GAF domain; Region: GAF_2; pfam13185
240292016453	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
240292016454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016455	ATP binding site [chemical binding]; other site
240292016456	Mg2+ binding site [ion binding]; other site
240292016457	G-X-G motif; other site
240292016458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016459	active site
240292016460	phosphorylation site [posttranslational modification]
240292016461	intermolecular recognition site; other site
240292016462	dimerization interface [polypeptide binding]; other site
240292016463	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016465	active site
240292016466	phosphorylation site [posttranslational modification]
240292016467	intermolecular recognition site; other site
240292016468	dimerization interface [polypeptide binding]; other site
240292016469	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016471	active site
240292016472	phosphorylation site [posttranslational modification]
240292016473	intermolecular recognition site; other site
240292016474	dimerization interface [polypeptide binding]; other site
240292016475	classical (c) SDRs; Region: SDR_c; cd05233
240292016476	NAD(P) binding site [chemical binding]; other site
240292016477	active site
240292016478	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
240292016479	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
240292016480	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
240292016481	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
240292016482	CheB methylesterase; Region: CheB_methylest; pfam01339
240292016483	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016485	active site
240292016486	phosphorylation site [posttranslational modification]
240292016487	intermolecular recognition site; other site
240292016488	dimerization interface [polypeptide binding]; other site
240292016489	PAS domain S-box; Region: sensory_box; TIGR00229
240292016490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016491	putative active site [active]
240292016492	heme pocket [chemical binding]; other site
240292016493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016495	dimer interface [polypeptide binding]; other site
240292016496	phosphorylation site [posttranslational modification]
240292016497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016498	ATP binding site [chemical binding]; other site
240292016499	Mg2+ binding site [ion binding]; other site
240292016500	G-X-G motif; other site
240292016501	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016503	active site
240292016504	phosphorylation site [posttranslational modification]
240292016505	intermolecular recognition site; other site
240292016506	dimerization interface [polypeptide binding]; other site
240292016507	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
240292016508	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
240292016509	Peptidase family M50; Region: Peptidase_M50; pfam02163
240292016510	active site
240292016511	putative substrate binding region [chemical binding]; other site
240292016512	FOG: CBS domain [General function prediction only]; Region: COG0517
240292016513	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
240292016514	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
240292016515	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
240292016516	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240292016517	YtxH-like protein; Region: YtxH; pfam12732
240292016518	hypothetical protein; Provisional; Region: PRK07377
240292016519	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
240292016520	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
240292016521	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
240292016522	putative ligand binding site [chemical binding]; other site
240292016523	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
240292016524	active site lid residues [active]
240292016525	substrate binding pocket [chemical binding]; other site
240292016526	catalytic residues [active]
240292016527	substrate-Mg2+ binding site; other site
240292016528	aspartate-rich region 1; other site
240292016529	aspartate-rich region 2; other site
240292016530	phytoene desaturase; Region: phytoene_desat; TIGR02731
240292016531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292016532	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
240292016533	active site
240292016534	catalytic triad [active]
240292016535	oxyanion hole [active]
240292016536	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240292016537	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
240292016538	NodB motif; other site
240292016539	active site
240292016540	catalytic site [active]
240292016541	metal binding site [ion binding]; metal-binding site
240292016542	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
240292016543	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
240292016544	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
240292016545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016546	binding surface
240292016547	TPR motif; other site
240292016548	TPR repeat; Region: TPR_11; pfam13414
240292016549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016550	binding surface
240292016551	TPR motif; other site
240292016552	TPR repeat; Region: TPR_11; pfam13414
240292016553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016554	binding surface
240292016555	TPR motif; other site
240292016556	TPR repeat; Region: TPR_11; pfam13414
240292016557	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292016558	Tetratricopeptide repeat; Region: TPR_17; pfam13431
240292016559	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
240292016560	TrkA-N domain; Region: TrkA_N; pfam02254
240292016561	TrkA-C domain; Region: TrkA_C; pfam02080
240292016562	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
240292016563	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
240292016564	tocopherol O-methyltransferase; Region: PLN02244
240292016565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240292016566	S-adenosylmethionine binding site [chemical binding]; other site
240292016567	PAS domain S-box; Region: sensory_box; TIGR00229
240292016568	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016569	putative active site [active]
240292016570	heme pocket [chemical binding]; other site
240292016571	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292016572	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240292016573	GAF domain; Region: GAF; pfam01590
240292016574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016575	dimer interface [polypeptide binding]; other site
240292016576	phosphorylation site [posttranslational modification]
240292016577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016578	ATP binding site [chemical binding]; other site
240292016579	Mg2+ binding site [ion binding]; other site
240292016580	G-X-G motif; other site
240292016581	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016583	active site
240292016584	phosphorylation site [posttranslational modification]
240292016585	intermolecular recognition site; other site
240292016586	dimerization interface [polypeptide binding]; other site
240292016587	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
240292016588	substrate binding pocket [chemical binding]; other site
240292016589	substrate-Mg2+ binding site; other site
240292016590	aspartate-rich region 1; other site
240292016591	aspartate-rich region 2; other site
240292016592	Predicted membrane protein/domain [Function unknown]; Region: COG1714
240292016593	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
240292016594	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
240292016595	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
240292016596	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
240292016597	putative dimer interface [polypeptide binding]; other site
240292016598	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
240292016599	TolA protein; Region: tolA_full; TIGR02794
240292016600	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292016601	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292016602	structural tetrad; other site
240292016603	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292016604	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292016605	structural tetrad; other site
240292016606	CHAT domain; Region: CHAT; cl17868
240292016607	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
240292016608	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
240292016609	N- and C-terminal domain interface [polypeptide binding]; other site
240292016610	active site
240292016611	MgATP binding site [chemical binding]; other site
240292016612	catalytic site [active]
240292016613	metal binding site [ion binding]; metal-binding site
240292016614	glycerol binding site [chemical binding]; other site
240292016615	homotetramer interface [polypeptide binding]; other site
240292016616	homodimer interface [polypeptide binding]; other site
240292016617	FBP binding site [chemical binding]; other site
240292016618	protein IIAGlc interface [polypeptide binding]; other site
240292016619	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292016620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016621	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016622	Uncharacterized conserved protein [Function unknown]; Region: COG1434
240292016623	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240292016624	putative active site [active]
240292016625	S-layer homology domain; Region: SLH; pfam00395
240292016626	S-layer homology domain; Region: SLH; pfam00395
240292016627	S-layer homology domain; Region: SLH; pfam00395
240292016628	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240292016629	Fasciclin domain; Region: Fasciclin; pfam02469
240292016630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016631	binding surface
240292016632	TPR motif; other site
240292016633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016636	binding surface
240292016637	TPR motif; other site
240292016638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016639	binding surface
240292016640	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016641	TPR motif; other site
240292016642	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016644	binding surface
240292016645	TPR motif; other site
240292016646	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016647	Tetratricopeptide repeat; Region: TPR_12; pfam13424
240292016648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
240292016649	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240292016650	putative active site [active]
240292016651	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
240292016652	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
240292016653	Walker A/P-loop; other site
240292016654	ATP binding site [chemical binding]; other site
240292016655	Q-loop/lid; other site
240292016656	ABC transporter signature motif; other site
240292016657	Walker B; other site
240292016658	D-loop; other site
240292016659	H-loop/switch region; other site
240292016660	TOBE domain; Region: TOBE_2; pfam08402
240292016661	GUN4-like; Region: GUN4; pfam05419
240292016662	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
240292016663	isocitrate dehydrogenase; Validated; Region: PRK07362
240292016664	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
240292016665	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240292016666	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
240292016667	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240292016668	acyl-activating enzyme (AAE) consensus motif; other site
240292016669	AMP binding site [chemical binding]; other site
240292016670	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016671	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240292016672	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240292016673	active site
240292016674	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240292016675	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240292016676	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016677	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292016678	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
240292016679	inhibitor-cofactor binding pocket; inhibition site
240292016680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292016681	catalytic residue [active]
240292016682	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
240292016683	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
240292016684	Condensation domain; Region: Condensation; pfam00668
240292016685	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240292016686	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292016687	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
240292016688	acyl-activating enzyme (AAE) consensus motif; other site
240292016689	AMP binding site [chemical binding]; other site
240292016690	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016691	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
240292016692	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240292016693	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240292016694	acyl-activating enzyme (AAE) consensus motif; other site
240292016695	AMP binding site [chemical binding]; other site
240292016696	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240292016697	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
240292016698	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
240292016699	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
240292016700	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240292016701	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240292016702	active site
240292016703	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292016704	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292016705	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240292016706	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
240292016707	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292016708	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240292016709	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
240292016710	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
240292016711	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
240292016712	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240292016713	Chain length determinant protein; Region: Wzz; pfam02706
240292016714	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
240292016715	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240292016716	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
240292016717	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
240292016718	NACHT domain; Region: NACHT; pfam05729
240292016719	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016720	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016721	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292016722	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016723	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292016724	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016725	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016726	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016727	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016728	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016729	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
240292016730	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
240292016731	active site
240292016732	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
240292016733	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016734	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016735	active site
240292016736	ATP binding site [chemical binding]; other site
240292016737	substrate binding site [chemical binding]; other site
240292016738	activation loop (A-loop); other site
240292016739	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292016740	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292016741	structural tetrad; other site
240292016742	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240292016743	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240292016744	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292016745	catalytic residue [active]
240292016746	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
240292016747	PLD-like domain; Region: PLDc_2; pfam13091
240292016748	putative active site [active]
240292016749	catalytic site [active]
240292016750	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
240292016751	PLD-like domain; Region: PLDc_2; pfam13091
240292016752	putative active site [active]
240292016753	catalytic site [active]
240292016754	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
240292016755	Helix-hairpin-helix motif; Region: HHH; pfam00633
240292016756	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
240292016757	AAA domain; Region: AAA_33; pfam13671
240292016758	ATP-binding site [chemical binding]; other site
240292016759	Gluconate-6-phosphate binding site [chemical binding]; other site
240292016760	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
240292016761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4340
240292016762	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
240292016763	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240292016764	HIGH motif; other site
240292016765	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240292016766	active site
240292016767	KMSKS motif; other site
240292016768	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240292016769	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016770	active site
240292016771	ATP binding site [chemical binding]; other site
240292016772	substrate binding site [chemical binding]; other site
240292016773	activation loop (A-loop); other site
240292016774	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016775	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016776	active site
240292016777	ATP binding site [chemical binding]; other site
240292016778	substrate binding site [chemical binding]; other site
240292016779	activation loop (A-loop); other site
240292016780	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
240292016781	SdiA-regulated; Region: SdiA-regulated; cd09971
240292016782	putative active site [active]
240292016783	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
240292016784	RNase_H superfamily; Region: RNase_H_2; pfam13482
240292016785	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
240292016786	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240292016787	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240292016788	catalytic residue [active]
240292016789	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
240292016790	HEAT repeats; Region: HEAT_2; pfam13646
240292016791	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
240292016792	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
240292016793	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
240292016794	PemK-like protein; Region: PemK; cl00995
240292016795	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
240292016796	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
240292016797	Uncharacterized conserved protein [Function unknown]; Region: COG0432
240292016798	NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350
240292016799	Uncharacterized conserved protein [Function unknown]; Region: COG0327
240292016800	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
240292016801	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
240292016802	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240292016803	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240292016804	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240292016805	P-loop; other site
240292016806	Magnesium ion binding site [ion binding]; other site
240292016807	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
240292016808	Sporulation and spore germination; Region: Germane; cl11253
240292016809	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292016810	active site
240292016811	catalytic residues [active]
240292016812	DNA binding site [nucleotide binding]
240292016813	Int/Topo IB signature motif; other site
240292016814	PAS fold; Region: PAS_4; pfam08448
240292016815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016816	putative active site [active]
240292016817	heme pocket [chemical binding]; other site
240292016818	PAS domain; Region: PAS_9; pfam13426
240292016819	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016820	putative active site [active]
240292016821	heme pocket [chemical binding]; other site
240292016822	PAS fold; Region: PAS_4; pfam08448
240292016823	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016824	putative active site [active]
240292016825	heme pocket [chemical binding]; other site
240292016826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016827	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240292016828	putative active site [active]
240292016829	heme pocket [chemical binding]; other site
240292016830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016831	putative active site [active]
240292016832	heme pocket [chemical binding]; other site
240292016833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240292016834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
240292016835	dimer interface [polypeptide binding]; other site
240292016836	phosphorylation site [posttranslational modification]
240292016837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016838	ATP binding site [chemical binding]; other site
240292016839	Mg2+ binding site [ion binding]; other site
240292016840	G-X-G motif; other site
240292016841	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
240292016842	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
240292016843	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
240292016844	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
240292016845	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
240292016846	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
240292016847	Response regulator receiver domain; Region: Response_reg; pfam00072
240292016848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016849	active site
240292016850	phosphorylation site [posttranslational modification]
240292016851	intermolecular recognition site; other site
240292016852	dimerization interface [polypeptide binding]; other site
240292016853	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
240292016854	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240292016855	anthranilate synthase; Provisional; Region: PRK13566
240292016856	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
240292016857	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
240292016858	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
240292016859	glutamine binding [chemical binding]; other site
240292016860	catalytic triad [active]
240292016861	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
240292016862	active site
240292016863	ribulose/triose binding site [chemical binding]; other site
240292016864	phosphate binding site [ion binding]; other site
240292016865	substrate (anthranilate) binding pocket [chemical binding]; other site
240292016866	product (indole) binding pocket [chemical binding]; other site
240292016867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292016868	binding surface
240292016869	TPR motif; other site
240292016870	TPR repeat; Region: TPR_11; pfam13414
240292016871	Uncharacterized conserved protein [Function unknown]; Region: COG5609
240292016872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016873	active site
240292016874	phosphorylation site [posttranslational modification]
240292016875	intermolecular recognition site; other site
240292016876	dimerization interface [polypeptide binding]; other site
240292016877	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
240292016878	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
240292016879	ABC-ATPase subunit  interface; other site
240292016880	dimer interface [polypeptide binding]; other site
240292016881	putative PBP binding regions; other site
240292016882	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
240292016883	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
240292016884	Walker A/P-loop; other site
240292016885	ATP binding site [chemical binding]; other site
240292016886	Q-loop/lid; other site
240292016887	ABC transporter signature motif; other site
240292016888	Walker B; other site
240292016889	D-loop; other site
240292016890	H-loop/switch region; other site
240292016891	S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192
240292016892	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
240292016893	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
240292016894	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
240292016895	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240292016896	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
240292016897	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292016898	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240292016899	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
240292016900	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292016901	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240292016902	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
240292016903	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
240292016904	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
240292016905	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
240292016906	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
240292016907	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
240292016908	Protein of unknown function (DUF1838); Region: DUF1838; pfam08894
240292016909	short chain dehydrogenase; Provisional; Region: PRK08303
240292016910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240292016911	NAD(P) binding site [chemical binding]; other site
240292016912	active site
240292016913	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240292016914	RNA binding surface [nucleotide binding]; other site
240292016915	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
240292016916	Cadmium resistance transporter; Region: Cad; pfam03596
240292016917	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016918	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292016919	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016920	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016921	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292016922	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016923	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
240292016924	putative hexamer interface [polypeptide binding]; other site
240292016925	putative hexagonal pore; other site
240292016926	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
240292016927	Hexamer interface [polypeptide binding]; other site
240292016928	Hexagonal pore residue; other site
240292016929	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240292016930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240292016931	motif II; other site
240292016932	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
240292016933	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240292016934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016935	active site
240292016936	phosphorylation site [posttranslational modification]
240292016937	intermolecular recognition site; other site
240292016938	dimerization interface [polypeptide binding]; other site
240292016939	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240292016940	DNA binding site [nucleotide binding]
240292016941	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
240292016942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240292016943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240292016944	putative substrate translocation pore; other site
240292016945	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
240292016946	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
240292016947	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
240292016948	metal binding site [ion binding]; metal-binding site
240292016949	Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572
240292016950	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
240292016951	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240292016952	inhibitor-cofactor binding pocket; inhibition site
240292016953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292016954	catalytic residue [active]
240292016955	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240292016956	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292016957	active site
240292016958	ATP binding site [chemical binding]; other site
240292016959	substrate binding site [chemical binding]; other site
240292016960	activation loop (A-loop); other site
240292016961	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016962	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
240292016963	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292016965	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240292016966	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240292016967	phosphopeptide binding site; other site
240292016968	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
240292016969	recombinase A; Provisional; Region: recA; PRK09354
240292016970	hexamer interface [polypeptide binding]; other site
240292016971	Walker A motif; other site
240292016972	ATP binding site [chemical binding]; other site
240292016973	Walker B motif; other site
240292016974	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
240292016975	dimer interface [polypeptide binding]; other site
240292016976	catalytic triad [active]
240292016977	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
240292016978	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
240292016979	active site
240292016980	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
240292016981	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240292016982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240292016983	putative active site [active]
240292016984	heme pocket [chemical binding]; other site
240292016985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240292016986	dimer interface [polypeptide binding]; other site
240292016987	phosphorylation site [posttranslational modification]
240292016988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240292016989	ATP binding site [chemical binding]; other site
240292016990	Mg2+ binding site [ion binding]; other site
240292016991	G-X-G motif; other site
240292016992	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240292016993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240292016994	active site
240292016995	phosphorylation site [posttranslational modification]
240292016996	intermolecular recognition site; other site
240292016997	dimerization interface [polypeptide binding]; other site
240292016998	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240292016999	Peptidase family M23; Region: Peptidase_M23; pfam01551
240292017000	Late competence development protein ComFB; Region: ComFB; pfam10719
240292017001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
240292017002	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
240292017003	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240292017004	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292017005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240292017006	DNA binding residues [nucleotide binding]
240292017007	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
240292017008	Putative zinc-finger; Region: zf-HC2; pfam13490
240292017009	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
240292017010	putative active site pocket [active]
240292017011	dimerization interface [polypeptide binding]; other site
240292017012	putative catalytic residue [active]
240292017013	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
240292017014	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
240292017015	HIGH motif; other site
240292017016	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
240292017017	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240292017018	active site
240292017019	KMSKS motif; other site
240292017020	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
240292017021	tRNA binding surface [nucleotide binding]; other site
240292017022	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
240292017023	nucleoside/Zn binding site; other site
240292017024	dimer interface [polypeptide binding]; other site
240292017025	catalytic motif [active]
240292017026	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
240292017027	active site
240292017028	dimerization interface [polypeptide binding]; other site
240292017029	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
240292017030	amidase catalytic site [active]
240292017031	Zn binding residues [ion binding]; other site
240292017032	substrate binding site [chemical binding]; other site
240292017033	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
240292017034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
240292017035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240292017036	AAA domain; Region: AAA_22; pfam13401
240292017037	Walker A motif; other site
240292017038	ATP binding site [chemical binding]; other site
240292017039	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
240292017040	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
240292017041	Integrase core domain; Region: rve; pfam00665
240292017042	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
240292017043	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
240292017044	conserved repeat domain; Region: B_ant_repeat; TIGR01451
240292017045	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
240292017046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
240292017047	threonine synthase; Validated; Region: PRK07591
240292017048	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
240292017049	homodimer interface [polypeptide binding]; other site
240292017050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292017051	catalytic residue [active]
240292017052	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
240292017053	MoaE interaction surface [polypeptide binding]; other site
240292017054	MoeB interaction surface [polypeptide binding]; other site
240292017055	thiocarboxylated glycine; other site
240292017056	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
240292017057	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
240292017058	tetramer interface [polypeptide binding]; other site
240292017059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292017060	catalytic residue [active]
240292017061	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
240292017062	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
240292017063	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
240292017064	diiron binding motif [ion binding]; other site
240292017065	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
240292017066	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240292017067	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292017068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292017069	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292017070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292017071	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292017072	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
240292017073	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292017074	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
240292017075	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240292017076	N-terminal plug; other site
240292017077	ligand-binding site [chemical binding]; other site
240292017078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
240292017079	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB [Energy production and conversion]; Region: NqrB; COG1805
240292017080	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240292017081	active site
240292017082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
240292017083	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
240292017084	Probable transposase; Region: OrfB_IS605; pfam01385
240292017085	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
240292017086	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
240292017087	PEP-CTERM motif; Region: VPEP; pfam07589
240292017088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292017089	binding surface
240292017090	TPR repeat; Region: TPR_11; pfam13414
240292017091	TPR motif; other site
240292017092	TPR repeat; Region: TPR_11; pfam13414
240292017093	TPR repeat; Region: TPR_11; pfam13414
240292017094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292017095	binding surface
240292017096	TPR motif; other site
240292017097	TPR repeat; Region: TPR_11; pfam13414
240292017098	TPR repeat; Region: TPR_11; pfam13414
240292017099	Tetratricopeptide repeat; Region: TPR_1; pfam00515
240292017100	Electron transfer DM13; Region: DM13; pfam10517
240292017101	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
240292017102	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
240292017103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240292017104	Coenzyme A binding pocket [chemical binding]; other site
240292017105	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
240292017106	EamA-like transporter family; Region: EamA; pfam00892
240292017107	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
240292017108	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240292017109	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
240292017110	catalytic triad [active]
240292017111	dimer interface [polypeptide binding]; other site
240292017112	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292017113	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
240292017114	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
240292017115	RNA binding site [nucleotide binding]; other site
240292017116	active site
240292017117	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
240292017118	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
240292017119	SnoaL-like domain; Region: SnoaL_2; pfam12680
240292017120	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240292017121	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
240292017122	Walker A/P-loop; other site
240292017123	ATP binding site [chemical binding]; other site
240292017124	Q-loop/lid; other site
240292017125	ABC transporter signature motif; other site
240292017126	Walker B; other site
240292017127	D-loop; other site
240292017128	H-loop/switch region; other site
240292017129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240292017130	binding surface
240292017131	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240292017132	TPR motif; other site
240292017133	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
240292017134	HD domain; Region: HD_4; pfam13328
240292017135	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
240292017136	synthetase active site [active]
240292017137	NTP binding site [chemical binding]; other site
240292017138	metal binding site [ion binding]; metal-binding site
240292017139	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
240292017140	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
240292017141	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
240292017142	putative active site [active]
240292017143	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
240292017144	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292017145	Walker A/P-loop; other site
240292017146	ATP binding site [chemical binding]; other site
240292017147	Q-loop/lid; other site
240292017148	ABC transporter signature motif; other site
240292017149	Walker B; other site
240292017150	D-loop; other site
240292017151	H-loop/switch region; other site
240292017152	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240292017153	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240292017154	Walker A/P-loop; other site
240292017155	ATP binding site [chemical binding]; other site
240292017156	Q-loop/lid; other site
240292017157	ABC transporter signature motif; other site
240292017158	Walker B; other site
240292017159	D-loop; other site
240292017160	H-loop/switch region; other site
240292017161	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240292017162	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240292017163	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240292017164	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240292017165	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240292017166	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240292017167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240292017168	Walker A/P-loop; other site
240292017169	ATP binding site [chemical binding]; other site
240292017170	Q-loop/lid; other site
240292017171	ABC transporter signature motif; other site
240292017172	Walker B; other site
240292017173	D-loop; other site
240292017174	H-loop/switch region; other site
240292017175	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
240292017176	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
240292017177	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
240292017178	Cadmium resistance transporter; Region: Cad; pfam03596
240292017179	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292017180	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
240292017181	C-terminal domain interface [polypeptide binding]; other site
240292017182	GSH binding site (G-site) [chemical binding]; other site
240292017183	dimer interface [polypeptide binding]; other site
240292017184	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
240292017185	N-terminal domain interface [polypeptide binding]; other site
240292017186	dimer interface [polypeptide binding]; other site
240292017187	substrate binding pocket (H-site) [chemical binding]; other site
240292017188	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
240292017189	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
240292017190	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240292017191	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
240292017192	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292017193	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292017194	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292017195	substrate binding pocket [chemical binding]; other site
240292017196	membrane-bound complex binding site; other site
240292017197	hinge residues; other site
240292017198	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292017199	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292017200	substrate binding pocket [chemical binding]; other site
240292017201	membrane-bound complex binding site; other site
240292017202	hinge residues; other site
240292017203	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
240292017204	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
240292017205	active site
240292017206	Methyltransferase domain; Region: Methyltransf_18; pfam12847
240292017207	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
240292017208	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292017209	C-terminal domain interface [polypeptide binding]; other site
240292017210	GSH binding site (G-site) [chemical binding]; other site
240292017211	dimer interface [polypeptide binding]; other site
240292017212	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
240292017213	N-terminal domain interface [polypeptide binding]; other site
240292017214	dimer interface [polypeptide binding]; other site
240292017215	substrate binding pocket (H-site) [chemical binding]; other site
240292017216	Phycobilisome protein; Region: Phycobilisome; cl08227
240292017217	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
240292017218	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240292017219	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
240292017220	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
240292017221	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
240292017222	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
240292017223	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
240292017224	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240292017225	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240292017226	active site
240292017227	catalytic tetrad [active]
240292017228	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
240292017229	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240292017230	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
240292017231	N-terminal domain interface [polypeptide binding]; other site
240292017232	dimer interface [polypeptide binding]; other site
240292017233	substrate binding pocket (H-site) [chemical binding]; other site
240292017234	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
240292017235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
240292017236	substrate binding pocket [chemical binding]; other site
240292017237	membrane-bound complex binding site; other site
240292017238	hinge residues; other site
240292017239	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
240292017240	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
240292017241	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
240292017242	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
240292017243	active site
240292017244	dimer interface [polypeptide binding]; other site
240292017245	non-prolyl cis peptide bond; other site
240292017246	insertion regions; other site
240292017247	serine O-acetyltransferase; Region: cysE; TIGR01172
240292017248	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
240292017249	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
240292017250	trimer interface [polypeptide binding]; other site
240292017251	active site
240292017252	substrate binding site [chemical binding]; other site
240292017253	CoA binding site [chemical binding]; other site
240292017254	Predicted transcriptional regulator [Transcription]; Region: COG1959
240292017255	Transcriptional regulator; Region: Rrf2; pfam02082
240292017256	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240292017257	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240292017258	dimer interface [polypeptide binding]; other site
240292017259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292017260	catalytic residue [active]
240292017261	Domain of unknown function (DUF202); Region: DUF202; pfam02656
240292017262	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
240292017263	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
240292017264	Cadmium resistance transporter; Region: Cad; pfam03596
240292017265	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
240292017266	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240292017267	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
240292017268	putative dimerization interface [polypeptide binding]; other site
240292017269	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
240292017270	Cadmium resistance transporter; Region: Cad; pfam03596
240292017271	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240292017272	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
240292017273	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
240292017274	active site
240292017275	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240292017276	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
240292017277	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240292017278	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292017279	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240292017280	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
240292017281	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
240292017282	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240292017283	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292017284	structural tetrad; other site
240292017285	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
240292017286	structural tetrad; other site
240292017287	Isochorismatase family; Region: Isochorismatase; pfam00857
240292017288	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
240292017289	catalytic triad [active]
240292017290	dimer interface [polypeptide binding]; other site
240292017291	conserved cis-peptide bond; other site
240292017292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
240292017293	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
240292017294	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
240292017295	hydroxyglutarate oxidase; Provisional; Region: PRK11728
240292017296	haloalkane dehalogenase; Provisional; Region: PRK03592
240292017297	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240292017298	Lipase (class 2); Region: Lipase_2; pfam01674
240292017299	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240292017300	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
240292017301	ferredoxin-sulfite reductase; Region: sir; TIGR02042
240292017302	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292017303	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240292017304	Predicted membrane protein [Function unknown]; Region: COG4371
240292017305	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292017306	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
240292017307	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
240292017308	thiS-thiF/thiG interaction site; other site
240292017309	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
240292017310	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
240292017311	thiamine phosphate binding site [chemical binding]; other site
240292017312	active site
240292017313	pyrophosphate binding site [ion binding]; other site
240292017314	Right handed beta helix region; Region: Beta_helix; pfam13229
240292017315	Protein of unknown function (DUF3257); Region: DUF3257; pfam11645
240292017316	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
240292017317	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
240292017318	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240292017319	active site
240292017320	ATP binding site [chemical binding]; other site
240292017321	substrate binding site [chemical binding]; other site
240292017322	activation loop (A-loop); other site
240292017323	Uncharacterized conserved protein [Function unknown]; Region: COG1262
240292017324	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240292017325	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
240292017326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240292017327	dimer interface [polypeptide binding]; other site
240292017328	conserved gate region; other site
240292017329	putative PBP binding loops; other site
240292017330	ABC-ATPase subunit interface; other site
240292017331	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292017332	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
240292017333	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292017334	active site
240292017335	catalytic residues [active]
240292017336	DNA binding site [nucleotide binding]
240292017337	Int/Topo IB signature motif; other site
240292017338	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240292017339	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
240292017340	putative ADP-binding pocket [chemical binding]; other site
240292017341	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
240292017342	homodimer interface [polypeptide binding]; other site
240292017343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240292017344	catalytic residue [active]
240292017345	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
240292017346	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
240292017347	nitrilase; Region: PLN02798
240292017348	putative active site [active]
240292017349	catalytic triad [active]
240292017350	dimer interface [polypeptide binding]; other site
240292017351	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
240292017352	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240292017353	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240292017354	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
240292017355	active site
240292017356	catalytic residues [active]
240292017357	metal binding site [ion binding]; metal-binding site
240292017358	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240292017359	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240292017360	protein binding site [polypeptide binding]; other site
240292017361	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
240292017362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
240292017363	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
240292017364	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240292017365	IHF - DNA interface [nucleotide binding]; other site
240292017366	IHF dimer interface [polypeptide binding]; other site
240292017367	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
240292017368	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240292017369	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240292017370	active site
240292017371	DNA binding site [nucleotide binding]
240292017372	Int/Topo IB signature motif; other site
240292017373	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
240292017374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240292017375	non-specific DNA binding site [nucleotide binding]; other site
240292017376	salt bridge; other site
240292017377	sequence-specific DNA binding site [nucleotide binding]; other site
240292017378	DdrB-like protein; Region: DdrB; pfam12747
240292017379	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240292017380	active site
240292017381	catalytic residues [active]
240292017382	DNA binding site [nucleotide binding]
240292017383	Int/Topo IB signature motif; other site