-- dump date 20140618_203646 -- class Genbank::misc_feature -- table misc_feature_note -- id note 891968000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 891968000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 891968000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968000004 Walker A motif; other site 891968000005 ATP binding site [chemical binding]; other site 891968000006 Walker B motif; other site 891968000007 arginine finger; other site 891968000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 891968000009 DnaA box-binding interface [nucleotide binding]; other site 891968000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 891968000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 891968000012 putative DNA binding surface [nucleotide binding]; other site 891968000013 dimer interface [polypeptide binding]; other site 891968000014 beta-clamp/clamp loader binding surface; other site 891968000015 beta-clamp/translesion DNA polymerase binding surface; other site 891968000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 891968000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968000018 Walker A/P-loop; other site 891968000019 ATP binding site [chemical binding]; other site 891968000020 Q-loop/lid; other site 891968000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968000022 ABC transporter signature motif; other site 891968000023 Walker B; other site 891968000024 D-loop; other site 891968000025 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 891968000026 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 891968000027 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 891968000028 Protein of unknown function (DUF721); Region: DUF721; pfam05258 891968000029 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 891968000030 non-heme iron binding site [ion binding]; other site 891968000031 tetramer interface [polypeptide binding]; other site 891968000032 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 891968000033 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 891968000034 N-acetyl-D-glucosamine binding site [chemical binding]; other site 891968000035 catalytic residue [active] 891968000036 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 891968000037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 891968000038 dimerization interface [polypeptide binding]; other site 891968000039 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 891968000040 PAS domain; Region: PAS; smart00091 891968000041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 891968000042 dimer interface [polypeptide binding]; other site 891968000043 phosphorylation site [posttranslational modification] 891968000044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968000045 ATP binding site [chemical binding]; other site 891968000046 Mg2+ binding site [ion binding]; other site 891968000047 G-X-G motif; other site 891968000048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 891968000049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968000050 active site 891968000051 phosphorylation site [posttranslational modification] 891968000052 intermolecular recognition site; other site 891968000053 dimerization interface [polypeptide binding]; other site 891968000054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 891968000055 DNA binding site [nucleotide binding] 891968000056 PhoU domain; Region: PhoU; pfam01895 891968000057 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 891968000058 PhoU domain; Region: PhoU; pfam01895 891968000059 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 891968000060 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 891968000061 Walker A/P-loop; other site 891968000062 ATP binding site [chemical binding]; other site 891968000063 Q-loop/lid; other site 891968000064 ABC transporter signature motif; other site 891968000065 Walker B; other site 891968000066 D-loop; other site 891968000067 H-loop/switch region; other site 891968000068 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 891968000069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000070 dimer interface [polypeptide binding]; other site 891968000071 conserved gate region; other site 891968000072 putative PBP binding loops; other site 891968000073 ABC-ATPase subunit interface; other site 891968000074 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 891968000075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000076 dimer interface [polypeptide binding]; other site 891968000077 conserved gate region; other site 891968000078 putative PBP binding loops; other site 891968000079 ABC-ATPase subunit interface; other site 891968000080 multifunctional aminopeptidase A; Provisional; Region: PRK00913 891968000081 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 891968000082 interface (dimer of trimers) [polypeptide binding]; other site 891968000083 Substrate-binding/catalytic site; other site 891968000084 Zn-binding sites [ion binding]; other site 891968000085 Peptidase family M48; Region: Peptidase_M48; pfam01435 891968000086 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 891968000087 Uncharacterized conserved protein [Function unknown]; Region: COG3461 891968000088 EamA-like transporter family; Region: EamA; pfam00892 891968000089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 891968000090 EamA-like transporter family; Region: EamA; pfam00892 891968000091 acetylornithine deacetylase; Provisional; Region: PRK08652 891968000092 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 891968000093 metal binding site [ion binding]; metal-binding site 891968000094 dimer interface [polypeptide binding]; other site 891968000095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 891968000096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 891968000097 Coenzyme A binding pocket [chemical binding]; other site 891968000098 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 891968000099 FAD binding domain; Region: FAD_binding_4; pfam01565 891968000100 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 891968000101 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 891968000102 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 891968000103 putative dimer interface [polypeptide binding]; other site 891968000104 [2Fe-2S] cluster binding site [ion binding]; other site 891968000105 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 891968000106 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 891968000107 dimer interface [polypeptide binding]; other site 891968000108 [2Fe-2S] cluster binding site [ion binding]; other site 891968000109 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 891968000110 SLBB domain; Region: SLBB; pfam10531 891968000111 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 891968000112 putative oxidoreductase; Provisional; Region: PRK12831 891968000113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 891968000114 Transposase, Mutator family; Region: Transposase_mut; pfam00872 891968000115 MULE transposase domain; Region: MULE; pfam10551 891968000116 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 891968000117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968000118 Mg2+ binding site [ion binding]; other site 891968000119 G-X-G motif; other site 891968000120 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 891968000121 anchoring element; other site 891968000122 dimer interface [polypeptide binding]; other site 891968000123 ATP binding site [chemical binding]; other site 891968000124 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 891968000125 active site 891968000126 putative metal-binding site [ion binding]; other site 891968000127 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 891968000128 Cache domain; Region: Cache_1; pfam02743 891968000129 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 891968000130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 891968000131 dimer interface [polypeptide binding]; other site 891968000132 putative CheW interface [polypeptide binding]; other site 891968000133 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968000134 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 891968000135 metal binding site [ion binding]; metal-binding site 891968000136 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 891968000137 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 891968000138 tetramer interface [polypeptide binding]; other site 891968000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968000140 catalytic residue [active] 891968000141 Uncharacterized conserved protein [Function unknown]; Region: COG1683 891968000142 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 891968000143 dimer interface [polypeptide binding]; other site 891968000144 FMN binding site [chemical binding]; other site 891968000145 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 891968000146 diiron binding motif [ion binding]; other site 891968000147 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 891968000148 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 891968000149 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 891968000150 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 891968000151 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 891968000152 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 891968000153 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 891968000154 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 891968000155 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 891968000156 PAS domain S-box; Region: sensory_box; TIGR00229 891968000157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 891968000158 putative active site [active] 891968000159 heme pocket [chemical binding]; other site 891968000160 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 891968000161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968000162 Zn2+ binding site [ion binding]; other site 891968000163 Mg2+ binding site [ion binding]; other site 891968000164 Part of AAA domain; Region: AAA_19; pfam13245 891968000165 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 891968000166 Family description; Region: UvrD_C_2; pfam13538 891968000167 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 891968000168 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 891968000169 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 891968000170 Uncharacterized conserved protein [Function unknown]; Region: COG1284 891968000171 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 891968000172 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 891968000173 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 891968000174 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 891968000175 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 891968000176 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 891968000177 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 891968000178 PhoU domain; Region: PhoU; pfam01895 891968000179 PhoU domain; Region: PhoU; pfam01895 891968000180 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 891968000181 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 891968000182 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 891968000183 inhibitor site; inhibition site 891968000184 active site 891968000185 dimer interface [polypeptide binding]; other site 891968000186 catalytic residue [active] 891968000187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 891968000188 EamA-like transporter family; Region: EamA; pfam00892 891968000189 EamA-like transporter family; Region: EamA; pfam00892 891968000190 Rubrerythrin [Energy production and conversion]; Region: COG1592 891968000191 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 891968000192 binuclear metal center [ion binding]; other site 891968000193 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 891968000194 iron binding site [ion binding]; other site 891968000195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968000196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968000197 putative substrate translocation pore; other site 891968000198 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 891968000199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968000200 Walker A/P-loop; other site 891968000201 ATP binding site [chemical binding]; other site 891968000202 Q-loop/lid; other site 891968000203 ABC transporter signature motif; other site 891968000204 Walker B; other site 891968000205 D-loop; other site 891968000206 H-loop/switch region; other site 891968000207 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 891968000208 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 891968000209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968000210 Walker A/P-loop; other site 891968000211 ATP binding site [chemical binding]; other site 891968000212 Q-loop/lid; other site 891968000213 ABC transporter signature motif; other site 891968000214 Walker B; other site 891968000215 D-loop; other site 891968000216 H-loop/switch region; other site 891968000217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 891968000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000219 dimer interface [polypeptide binding]; other site 891968000220 conserved gate region; other site 891968000221 putative PBP binding loops; other site 891968000222 ABC-ATPase subunit interface; other site 891968000223 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 891968000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 891968000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000226 putative PBP binding loops; other site 891968000227 dimer interface [polypeptide binding]; other site 891968000228 ABC-ATPase subunit interface; other site 891968000229 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 891968000230 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968000231 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968000232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 891968000233 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 891968000234 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 891968000235 active site 891968000236 FMN binding site [chemical binding]; other site 891968000237 substrate binding site [chemical binding]; other site 891968000238 putative catalytic residue [active] 891968000239 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 891968000240 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 891968000241 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 891968000242 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 891968000243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 891968000244 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 891968000245 HTH domain; Region: HTH_11; pfam08279 891968000246 3H domain; Region: 3H; pfam02829 891968000247 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 891968000248 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 891968000249 Na binding site [ion binding]; other site 891968000250 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 891968000251 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 891968000252 Acylphosphatase; Region: Acylphosphatase; pfam00708 891968000253 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 891968000254 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 891968000255 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 891968000256 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 891968000257 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 891968000258 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 891968000259 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 891968000260 active site 891968000261 NTP binding site [chemical binding]; other site 891968000262 metal binding triad [ion binding]; metal-binding site 891968000263 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 891968000264 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 891968000265 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 891968000266 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 891968000267 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 891968000268 hypothetical protein; Provisional; Region: PRK08609 891968000269 active site 891968000270 primer binding site [nucleotide binding]; other site 891968000271 NTP binding site [chemical binding]; other site 891968000272 metal binding triad [ion binding]; metal-binding site 891968000273 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 891968000274 active site 891968000275 EamA-like transporter family; Region: EamA; pfam00892 891968000276 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 891968000277 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 891968000278 putative dimer interface [polypeptide binding]; other site 891968000279 [2Fe-2S] cluster binding site [ion binding]; other site 891968000280 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 891968000281 dimer interface [polypeptide binding]; other site 891968000282 [2Fe-2S] cluster binding site [ion binding]; other site 891968000283 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 891968000284 SLBB domain; Region: SLBB; pfam10531 891968000285 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 891968000286 4Fe-4S binding domain; Region: Fer4; pfam00037 891968000287 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968000288 4Fe-4S binding domain; Region: Fer4; pfam00037 891968000289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968000290 catalytic loop [active] 891968000291 iron binding site [ion binding]; other site 891968000292 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968000293 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968000294 4Fe-4S binding domain; Region: Fer4; cl02805 891968000295 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 891968000296 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 891968000297 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 891968000298 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 891968000299 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 891968000300 Cation efflux family; Region: Cation_efflux; pfam01545 891968000301 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 891968000302 diiron binding motif [ion binding]; other site 891968000303 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 891968000304 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 891968000305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 891968000306 putative active site [active] 891968000307 heme pocket [chemical binding]; other site 891968000308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 891968000309 putative active site [active] 891968000310 heme pocket [chemical binding]; other site 891968000311 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 891968000312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 891968000313 metal binding site [ion binding]; metal-binding site 891968000314 active site 891968000315 I-site; other site 891968000316 homoserine dehydrogenase; Provisional; Region: PRK06270 891968000317 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 891968000318 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 891968000319 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 891968000320 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 891968000321 Walker A/P-loop; other site 891968000322 ATP binding site [chemical binding]; other site 891968000323 Q-loop/lid; other site 891968000324 ABC transporter signature motif; other site 891968000325 Walker B; other site 891968000326 D-loop; other site 891968000327 H-loop/switch region; other site 891968000328 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 891968000329 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 891968000330 Walker A/P-loop; other site 891968000331 ATP binding site [chemical binding]; other site 891968000332 Q-loop/lid; other site 891968000333 ABC transporter signature motif; other site 891968000334 Walker B; other site 891968000335 D-loop; other site 891968000336 H-loop/switch region; other site 891968000337 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968000338 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 891968000339 TM-ABC transporter signature motif; other site 891968000340 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968000341 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 891968000342 TM-ABC transporter signature motif; other site 891968000343 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 891968000344 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 891968000345 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 891968000346 Ferritin-like domain; Region: Ferritin; pfam00210 891968000347 dinuclear metal binding motif [ion binding]; other site 891968000348 pyruvate phosphate dikinase; Provisional; Region: PRK09279 891968000349 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 891968000350 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 891968000351 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 891968000352 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 891968000353 homodimer interaction site [polypeptide binding]; other site 891968000354 cofactor binding site; other site 891968000355 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 891968000356 active site 891968000357 dimer interfaces [polypeptide binding]; other site 891968000358 catalytic residues [active] 891968000359 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 891968000360 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 891968000361 Cl- selectivity filter; other site 891968000362 Cl- binding residues [ion binding]; other site 891968000363 pore gating glutamate residue; other site 891968000364 dimer interface [polypeptide binding]; other site 891968000365 diaminopimelate decarboxylase; Region: lysA; TIGR01048 891968000366 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 891968000367 active site 891968000368 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 891968000369 substrate binding site [chemical binding]; other site 891968000370 catalytic residues [active] 891968000371 dimer interface [polypeptide binding]; other site 891968000372 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 891968000373 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 891968000374 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 891968000375 Ubiquitin-like proteins; Region: UBQ; cl00155 891968000376 charged pocket; other site 891968000377 hydrophobic patch; other site 891968000378 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 891968000379 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 891968000380 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 891968000381 putative RNA binding site [nucleotide binding]; other site 891968000382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968000383 S-adenosylmethionine binding site [chemical binding]; other site 891968000384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968000385 putative substrate translocation pore; other site 891968000386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968000387 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 891968000388 active site 1 [active] 891968000389 dimer interface [polypeptide binding]; other site 891968000390 hexamer interface [polypeptide binding]; other site 891968000391 active site 2 [active] 891968000392 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 891968000393 Peptidase family M23; Region: Peptidase_M23; pfam01551 891968000394 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 891968000395 amphipathic channel; other site 891968000396 Asn-Pro-Ala signature motifs; other site 891968000397 Uncharacterized conserved protein [Function unknown]; Region: COG2006 891968000398 Domain of unknown function (DUF362); Region: DUF362; pfam04015 891968000399 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 891968000400 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 891968000401 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 891968000402 NAD binding site [chemical binding]; other site 891968000403 Phe binding site; other site 891968000404 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 891968000405 hypothetical protein; Provisional; Region: PRK02399 891968000406 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 891968000407 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 891968000408 intersubunit interface [polypeptide binding]; other site 891968000409 active site 891968000410 Zn2+ binding site [ion binding]; other site 891968000411 Sensory domain found in PocR; Region: PocR; pfam10114 891968000412 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 891968000413 Histidine kinase; Region: His_kinase; pfam06580 891968000414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968000415 ATP binding site [chemical binding]; other site 891968000416 Mg2+ binding site [ion binding]; other site 891968000417 G-X-G motif; other site 891968000418 Response regulator receiver domain; Region: Response_reg; pfam00072 891968000419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968000420 active site 891968000421 phosphorylation site [posttranslational modification] 891968000422 intermolecular recognition site; other site 891968000423 dimerization interface [polypeptide binding]; other site 891968000424 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 891968000425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 891968000426 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 891968000427 putative hexamer interface [polypeptide binding]; other site 891968000428 putative hexagonal pore; other site 891968000429 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 891968000430 G3 box; other site 891968000431 Switch II region; other site 891968000432 GTP/Mg2+ binding site [chemical binding]; other site 891968000433 G4 box; other site 891968000434 G5 box; other site 891968000435 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 891968000436 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 891968000437 Hexamer interface [polypeptide binding]; other site 891968000438 Hexagonal pore residue; other site 891968000439 propanediol utilization protein PduB; Provisional; Region: PRK15415 891968000440 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 891968000441 putative hexamer interface [polypeptide binding]; other site 891968000442 putative hexagonal pore; other site 891968000443 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 891968000444 putative hexamer interface [polypeptide binding]; other site 891968000445 putative hexagonal pore; other site 891968000446 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 891968000447 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 891968000448 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 891968000449 alpha-beta subunit interface [polypeptide binding]; other site 891968000450 alpha-gamma subunit interface [polypeptide binding]; other site 891968000451 active site 891968000452 substrate and K+ binding site; other site 891968000453 K+ binding site [ion binding]; other site 891968000454 cobalamin binding site [chemical binding]; other site 891968000455 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 891968000456 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 891968000457 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 891968000458 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 891968000459 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 891968000460 Hexamer interface [polypeptide binding]; other site 891968000461 Hexagonal pore residue; other site 891968000462 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 891968000463 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 891968000464 Hexamer interface [polypeptide binding]; other site 891968000465 Hexagonal pore residue; other site 891968000466 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 891968000467 Propanediol utilisation protein PduL; Region: PduL; pfam06130 891968000468 Propanediol utilisation protein PduL; Region: PduL; pfam06130 891968000469 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 891968000470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 891968000471 nucleotide binding site [chemical binding]; other site 891968000472 Cell division protein FtsA; Region: FtsA; pfam14450 891968000473 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 891968000474 Hexamer/Pentamer interface [polypeptide binding]; other site 891968000475 central pore; other site 891968000476 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 891968000477 Domain of unknown function (DUF336); Region: DUF336; cl01249 891968000478 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 891968000479 NAD(P) binding site [chemical binding]; other site 891968000480 catalytic residues [active] 891968000481 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 891968000482 SLBB domain; Region: SLBB; pfam10531 891968000483 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 891968000484 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 891968000485 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 891968000486 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 891968000487 putative hexamer interface [polypeptide binding]; other site 891968000488 putative hexagonal pore; other site 891968000489 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 891968000490 putative hexamer interface [polypeptide binding]; other site 891968000491 putative hexagonal pore; other site 891968000492 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 891968000493 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 891968000494 dimer interface [polypeptide binding]; other site 891968000495 active site 891968000496 metal binding site [ion binding]; metal-binding site 891968000497 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 891968000498 ATP-NAD kinase; Region: NAD_kinase; pfam01513 891968000499 hypothetical protein; Provisional; Region: PRK13690 891968000500 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 891968000501 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 891968000502 B12 binding site [chemical binding]; other site 891968000503 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 891968000504 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 891968000505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968000506 catalytic residue [active] 891968000507 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 891968000508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968000509 catalytic residue [active] 891968000510 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 891968000511 metal binding site 2 [ion binding]; metal-binding site 891968000512 putative DNA binding helix; other site 891968000513 metal binding site 1 [ion binding]; metal-binding site 891968000514 dimer interface [polypeptide binding]; other site 891968000515 structural Zn2+ binding site [ion binding]; other site 891968000516 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 891968000517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968000518 Walker A/P-loop; other site 891968000519 ATP binding site [chemical binding]; other site 891968000520 Q-loop/lid; other site 891968000521 ABC transporter signature motif; other site 891968000522 Walker B; other site 891968000523 D-loop; other site 891968000524 H-loop/switch region; other site 891968000525 ABC-2 type transporter; Region: ABC2_membrane; cl17235 891968000526 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 891968000527 seryl-tRNA synthetase; Provisional; Region: PRK05431 891968000528 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 891968000529 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968000530 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968000531 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 891968000532 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 891968000533 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 891968000534 ABC-ATPase subunit interface; other site 891968000535 dimer interface [polypeptide binding]; other site 891968000536 putative PBP binding regions; other site 891968000537 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 891968000538 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 891968000539 Walker A/P-loop; other site 891968000540 ATP binding site [chemical binding]; other site 891968000541 Q-loop/lid; other site 891968000542 ABC transporter signature motif; other site 891968000543 Walker B; other site 891968000544 D-loop; other site 891968000545 H-loop/switch region; other site 891968000546 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 891968000547 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 891968000548 putative metal binding site [ion binding]; other site 891968000549 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 891968000550 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 891968000551 Walker A motif; other site 891968000552 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 891968000553 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 891968000554 putative valine binding site [chemical binding]; other site 891968000555 dimer interface [polypeptide binding]; other site 891968000556 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 891968000557 ketol-acid reductoisomerase; Provisional; Region: PRK05479 891968000558 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 891968000559 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 891968000560 2-isopropylmalate synthase; Validated; Region: PRK00915 891968000561 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 891968000562 active site 891968000563 catalytic residues [active] 891968000564 metal binding site [ion binding]; metal-binding site 891968000565 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 891968000566 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 891968000567 tartrate dehydrogenase; Region: TTC; TIGR02089 891968000568 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 891968000569 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 891968000570 PYR/PP interface [polypeptide binding]; other site 891968000571 dimer interface [polypeptide binding]; other site 891968000572 TPP binding site [chemical binding]; other site 891968000573 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 891968000574 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 891968000575 TPP-binding site [chemical binding]; other site 891968000576 dimer interface [polypeptide binding]; other site 891968000577 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 891968000578 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968000579 TM-ABC transporter signature motif; other site 891968000580 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 891968000581 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968000582 TM-ABC transporter signature motif; other site 891968000583 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 891968000584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968000585 Walker A/P-loop; other site 891968000586 ATP binding site [chemical binding]; other site 891968000587 Q-loop/lid; other site 891968000588 ABC transporter signature motif; other site 891968000589 Walker B; other site 891968000590 D-loop; other site 891968000591 H-loop/switch region; other site 891968000592 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 891968000593 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 891968000594 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 891968000595 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 891968000596 Walker A/P-loop; other site 891968000597 ATP binding site [chemical binding]; other site 891968000598 Q-loop/lid; other site 891968000599 ABC transporter signature motif; other site 891968000600 Walker B; other site 891968000601 D-loop; other site 891968000602 H-loop/switch region; other site 891968000603 FOG: CBS domain [General function prediction only]; Region: COG0517 891968000604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 891968000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000606 dimer interface [polypeptide binding]; other site 891968000607 conserved gate region; other site 891968000608 ABC-ATPase subunit interface; other site 891968000609 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 891968000610 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 891968000611 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 891968000612 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 891968000613 N-terminal plug; other site 891968000614 ligand-binding site [chemical binding]; other site 891968000615 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 891968000616 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 891968000617 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 891968000618 putative L-serine binding site [chemical binding]; other site 891968000619 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 891968000620 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 891968000621 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 891968000622 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 891968000623 P-loop; other site 891968000624 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968000625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 891968000626 dimer interface [polypeptide binding]; other site 891968000627 putative CheW interface [polypeptide binding]; other site 891968000628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 891968000629 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 891968000630 substrate binding pocket [chemical binding]; other site 891968000631 membrane-bound complex binding site; other site 891968000632 hinge residues; other site 891968000633 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 891968000634 putative FMN binding site [chemical binding]; other site 891968000635 DNA gyrase subunit A; Validated; Region: PRK05560 891968000636 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 891968000637 CAP-like domain; other site 891968000638 active site 891968000639 primary dimer interface [polypeptide binding]; other site 891968000640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000641 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000642 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000643 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000644 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000645 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 891968000646 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 891968000647 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 891968000648 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 891968000649 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 891968000650 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 891968000651 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 891968000652 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 891968000653 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 891968000654 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 891968000655 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 891968000656 intersubunit interface [polypeptide binding]; other site 891968000657 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 891968000658 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 891968000659 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 891968000660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 891968000661 NMT1/THI5 like; Region: NMT1; pfam09084 891968000662 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 891968000663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000664 dimer interface [polypeptide binding]; other site 891968000665 conserved gate region; other site 891968000666 putative PBP binding loops; other site 891968000667 ABC-ATPase subunit interface; other site 891968000668 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 891968000669 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 891968000670 Walker A/P-loop; other site 891968000671 ATP binding site [chemical binding]; other site 891968000672 Q-loop/lid; other site 891968000673 ABC transporter signature motif; other site 891968000674 Walker B; other site 891968000675 D-loop; other site 891968000676 H-loop/switch region; other site 891968000677 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 891968000678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968000679 Walker A/P-loop; other site 891968000680 ATP binding site [chemical binding]; other site 891968000681 Q-loop/lid; other site 891968000682 ABC transporter signature motif; other site 891968000683 Walker B; other site 891968000684 D-loop; other site 891968000685 H-loop/switch region; other site 891968000686 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 891968000687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968000688 dimer interface [polypeptide binding]; other site 891968000689 conserved gate region; other site 891968000690 putative PBP binding loops; other site 891968000691 ABC-ATPase subunit interface; other site 891968000692 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 891968000693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 891968000694 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 891968000695 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 891968000696 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 891968000697 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 891968000698 phosphate binding site [ion binding]; other site 891968000699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 891968000700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 891968000701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968000702 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 891968000703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968000704 catalytic residue [active] 891968000705 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 891968000706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 891968000707 putative acyl-acceptor binding pocket; other site 891968000708 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 891968000709 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 891968000710 Chromate transporter; Region: Chromate_transp; pfam02417 891968000711 Chromate transporter; Region: Chromate_transp; pfam02417 891968000712 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 891968000713 aspartate racemase; Region: asp_race; TIGR00035 891968000714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 891968000715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 891968000716 NAD(P) binding site [chemical binding]; other site 891968000717 active site 891968000718 hypothetical protein; Provisional; Region: PRK10279 891968000719 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 891968000720 nucleophile elbow; other site 891968000721 elongation factor Tu; Reviewed; Region: PRK00049 891968000722 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 891968000723 G1 box; other site 891968000724 GEF interaction site [polypeptide binding]; other site 891968000725 GTP/Mg2+ binding site [chemical binding]; other site 891968000726 Switch I region; other site 891968000727 G2 box; other site 891968000728 G3 box; other site 891968000729 Switch II region; other site 891968000730 G4 box; other site 891968000731 G5 box; other site 891968000732 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 891968000733 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 891968000734 Antibiotic Binding Site [chemical binding]; other site 891968000735 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 891968000736 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 891968000737 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 891968000738 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 891968000739 putative homodimer interface [polypeptide binding]; other site 891968000740 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 891968000741 heterodimer interface [polypeptide binding]; other site 891968000742 homodimer interface [polypeptide binding]; other site 891968000743 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 891968000744 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 891968000745 23S rRNA interface [nucleotide binding]; other site 891968000746 L7/L12 interface [polypeptide binding]; other site 891968000747 putative thiostrepton binding site; other site 891968000748 L25 interface [polypeptide binding]; other site 891968000749 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 891968000750 mRNA/rRNA interface [nucleotide binding]; other site 891968000751 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 891968000752 23S rRNA interface [nucleotide binding]; other site 891968000753 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 891968000754 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 891968000755 core dimer interface [polypeptide binding]; other site 891968000756 peripheral dimer interface [polypeptide binding]; other site 891968000757 L10 interface [polypeptide binding]; other site 891968000758 L11 interface [polypeptide binding]; other site 891968000759 putative EF-Tu interaction site [polypeptide binding]; other site 891968000760 putative EF-G interaction site [polypeptide binding]; other site 891968000761 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 891968000762 Active_site [active] 891968000763 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 891968000764 trimer interface [polypeptide binding]; other site 891968000765 active site 891968000766 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 891968000767 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 891968000768 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 891968000769 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 891968000770 substrate binding pocket [chemical binding]; other site 891968000771 dimer interface [polypeptide binding]; other site 891968000772 inhibitor binding site; inhibition site 891968000773 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 891968000774 B12 binding site [chemical binding]; other site 891968000775 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 891968000776 FAD binding site [chemical binding]; other site 891968000777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968000778 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 891968000779 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 891968000780 homodimer interface [polypeptide binding]; other site 891968000781 substrate-cofactor binding pocket; other site 891968000782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968000783 catalytic residue [active] 891968000784 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 891968000785 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 891968000786 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 891968000787 RNA/DNA hybrid binding site [nucleotide binding]; other site 891968000788 active site 891968000789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968000790 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968000791 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 891968000792 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 891968000793 HlyD family secretion protein; Region: HlyD_3; pfam13437 891968000794 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 891968000795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968000796 putative substrate translocation pore; other site 891968000797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968000798 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 891968000799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 891968000800 Predicted thioesterase [General function prediction only]; Region: COG5496 891968000801 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 891968000802 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 891968000803 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 891968000804 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968000805 dimer interface [polypeptide binding]; other site 891968000806 PYR/PP interface [polypeptide binding]; other site 891968000807 TPP binding site [chemical binding]; other site 891968000808 substrate binding site [chemical binding]; other site 891968000809 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968000810 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 891968000811 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 891968000812 TPP-binding site [chemical binding]; other site 891968000813 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 891968000814 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 891968000815 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 891968000816 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 891968000817 phosphate binding site [ion binding]; other site 891968000818 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 891968000819 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 891968000820 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 891968000821 intracellular protease, PfpI family; Region: PfpI; TIGR01382 891968000822 proposed catalytic triad [active] 891968000823 conserved cys residue [active] 891968000824 Uncharacterized conserved protein [Function unknown]; Region: COG1633 891968000825 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 891968000826 diiron binding motif [ion binding]; other site 891968000827 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 891968000828 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 891968000829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 891968000830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 891968000831 CoA binding domain; Region: CoA_binding_2; pfam13380 891968000832 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 891968000833 active site 891968000834 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 891968000835 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968000836 dimer interface [polypeptide binding]; other site 891968000837 PYR/PP interface [polypeptide binding]; other site 891968000838 TPP binding site [chemical binding]; other site 891968000839 substrate binding site [chemical binding]; other site 891968000840 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 891968000841 TPP-binding site; other site 891968000842 4Fe-4S binding domain; Region: Fer4; pfam00037 891968000843 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 891968000844 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 891968000845 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 891968000846 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 891968000847 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 891968000848 Catalytic site [active] 891968000849 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 891968000850 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 891968000851 GTP/Mg2+ binding site [chemical binding]; other site 891968000852 G4 box; other site 891968000853 G5 box; other site 891968000854 G1 box; other site 891968000855 Switch I region; other site 891968000856 G2 box; other site 891968000857 G3 box; other site 891968000858 Switch II region; other site 891968000859 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 891968000860 RNA/DNA hybrid binding site [nucleotide binding]; other site 891968000861 active site 891968000862 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 891968000863 hypothetical protein; Reviewed; Region: PRK12497 891968000864 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 891968000865 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 891968000866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968000867 Walker A motif; other site 891968000868 ATP binding site [chemical binding]; other site 891968000869 Walker B motif; other site 891968000870 arginine finger; other site 891968000871 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 891968000872 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 891968000873 DNA protecting protein DprA; Region: dprA; TIGR00732 891968000874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 891968000875 putative DNA binding site [nucleotide binding]; other site 891968000876 putative Zn2+ binding site [ion binding]; other site 891968000877 DNA topoisomerase I; Validated; Region: PRK05582 891968000878 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 891968000879 active site 891968000880 interdomain interaction site; other site 891968000881 putative metal-binding site [ion binding]; other site 891968000882 nucleotide binding site [chemical binding]; other site 891968000883 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 891968000884 domain I; other site 891968000885 DNA binding groove [nucleotide binding] 891968000886 phosphate binding site [ion binding]; other site 891968000887 domain II; other site 891968000888 domain III; other site 891968000889 nucleotide binding site [chemical binding]; other site 891968000890 catalytic site [active] 891968000891 domain IV; other site 891968000892 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 891968000893 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 891968000894 Glucose inhibited division protein A; Region: GIDA; pfam01134 891968000895 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 891968000896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 891968000897 active site 891968000898 DNA binding site [nucleotide binding] 891968000899 Int/Topo IB signature motif; other site 891968000900 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 891968000901 active site 891968000902 HslU subunit interaction site [polypeptide binding]; other site 891968000903 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 891968000904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968000905 Walker A motif; other site 891968000906 ATP binding site [chemical binding]; other site 891968000907 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 891968000908 Walker B motif; other site 891968000909 arginine finger; other site 891968000910 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 891968000911 transcriptional repressor CodY; Validated; Region: PRK04158 891968000912 CodY GAF-like domain; Region: CodY; pfam06018 891968000913 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 891968000914 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 891968000915 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 891968000916 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 891968000917 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 891968000918 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 891968000919 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 891968000920 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 891968000921 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 891968000922 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 891968000923 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 891968000924 FliG C-terminal domain; Region: FliG_C; pfam01706 891968000925 Flagellar assembly protein FliH; Region: FliH; pfam02108 891968000926 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 891968000927 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968000928 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 891968000929 Walker A motif/ATP binding site; other site 891968000930 Walker B motif; other site 891968000931 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 891968000932 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 891968000933 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 891968000934 N-acetyl-D-glucosamine binding site [chemical binding]; other site 891968000935 catalytic residue [active] 891968000936 Uncharacterized conserved protein [Function unknown]; Region: COG3334 891968000937 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 891968000938 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 891968000939 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 891968000940 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 891968000941 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 891968000942 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 891968000943 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 891968000944 Flagellar protein (FlbD); Region: FlbD; pfam06289 891968000945 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 891968000946 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 891968000947 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 891968000948 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 891968000949 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 891968000950 ligand binding site [chemical binding]; other site 891968000951 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 891968000952 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 891968000953 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 891968000954 flagellar motor switch protein; Validated; Region: PRK08119 891968000955 flagellar motor switch protein FliN; Region: fliN; TIGR02480 891968000956 Response regulator receiver domain; Region: Response_reg; pfam00072 891968000957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968000958 active site 891968000959 phosphorylation site [posttranslational modification] 891968000960 intermolecular recognition site; other site 891968000961 dimerization interface [polypeptide binding]; other site 891968000962 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 891968000963 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 891968000964 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 891968000965 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 891968000966 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 891968000967 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 891968000968 FHIPEP family; Region: FHIPEP; pfam00771 891968000969 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 891968000970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968000971 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968000972 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 891968000973 PilZ domain; Region: PilZ; pfam07238 891968000974 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 891968000975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968000976 active site 891968000977 phosphorylation site [posttranslational modification] 891968000978 intermolecular recognition site; other site 891968000979 dimerization interface [polypeptide binding]; other site 891968000980 CheB methylesterase; Region: CheB_methylest; pfam01339 891968000981 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 891968000982 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 891968000983 putative binding surface; other site 891968000984 active site 891968000985 P2 response regulator binding domain; Region: P2; pfam07194 891968000986 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 891968000987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968000988 ATP binding site [chemical binding]; other site 891968000989 Mg2+ binding site [ion binding]; other site 891968000990 G-X-G motif; other site 891968000991 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 891968000992 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 891968000993 CheC-like family; Region: CheC; pfam04509 891968000994 Chemotaxis phosphatase CheX; Region: CheX; cl15816 891968000995 CheD chemotactic sensory transduction; Region: CheD; cl00810 891968000996 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 891968000997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 891968000998 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 891968000999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 891968001000 DNA binding residues [nucleotide binding] 891968001001 Protein of unknown function (DUF342); Region: DUF342; pfam03961 891968001002 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 891968001003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 891968001004 RNA binding site [nucleotide binding]; other site 891968001005 Protein of unknown function (DUF501); Region: DUF501; cl00652 891968001006 exopolyphosphatase; Region: exo_poly_only; TIGR03706 891968001007 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 891968001008 argininosuccinate lyase; Provisional; Region: PRK00855 891968001009 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 891968001010 active sites [active] 891968001011 tetramer interface [polypeptide binding]; other site 891968001012 flagellar assembly protein FliW; Provisional; Region: PRK13285 891968001013 Global regulator protein family; Region: CsrA; pfam02599 891968001014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 891968001015 catalytic core [active] 891968001016 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 891968001017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 891968001018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 891968001019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 891968001020 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 891968001021 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 891968001022 Surface antigen; Region: Bac_surface_Ag; pfam01103 891968001023 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 891968001024 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 891968001025 trimer interface [polypeptide binding]; other site 891968001026 active site 891968001027 UDP-GlcNAc binding site [chemical binding]; other site 891968001028 lipid binding site [chemical binding]; lipid-binding site 891968001029 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 891968001030 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 891968001031 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 891968001032 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 891968001033 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 891968001034 active site 891968001035 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 891968001036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968001037 active site 891968001038 motif I; other site 891968001039 motif II; other site 891968001040 Predicted permeases [General function prediction only]; Region: COG0795 891968001041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 891968001042 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 891968001043 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 891968001044 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 891968001045 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 891968001046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 891968001047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 891968001048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968001049 Walker A/P-loop; other site 891968001050 ATP binding site [chemical binding]; other site 891968001051 Q-loop/lid; other site 891968001052 ABC transporter signature motif; other site 891968001053 Walker B; other site 891968001054 D-loop; other site 891968001055 H-loop/switch region; other site 891968001056 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 891968001057 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 891968001058 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 891968001059 PhoU domain; Region: PhoU; pfam01895 891968001060 PhoU domain; Region: PhoU; pfam01895 891968001061 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 891968001062 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 891968001063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 891968001064 conserved hypothetical protein; Region: TIGR03492 891968001065 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 891968001066 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 891968001067 Ligand binding site; other site 891968001068 oligomer interface; other site 891968001069 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 891968001070 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 891968001071 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 891968001072 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 891968001073 putative active site [active] 891968001074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 891968001075 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 891968001076 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 891968001077 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 891968001078 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 891968001079 active site 891968001080 NAD binding site [chemical binding]; other site 891968001081 metal binding site [ion binding]; metal-binding site 891968001082 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 891968001083 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 891968001084 inhibitor-cofactor binding pocket; inhibition site 891968001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001086 catalytic residue [active] 891968001087 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 891968001088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 891968001089 Coenzyme A binding pocket [chemical binding]; other site 891968001090 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 891968001091 Carbon starvation protein CstA; Region: CstA; pfam02554 891968001092 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 891968001093 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 891968001094 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 891968001095 P loop; other site 891968001096 Nucleotide binding site [chemical binding]; other site 891968001097 DTAP/Switch II; other site 891968001098 Switch I; other site 891968001099 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 891968001100 Protein of unknown function (DUF554); Region: DUF554; pfam04474 891968001101 glycogen branching enzyme; Provisional; Region: PRK12313 891968001102 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 891968001103 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 891968001104 active site 891968001105 catalytic site [active] 891968001106 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 891968001107 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 891968001108 active site 891968001109 catalytic site [active] 891968001110 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 891968001111 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 891968001112 catalytic center binding site [active] 891968001113 ATP binding site [chemical binding]; other site 891968001114 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 891968001115 dihydropteroate synthase; Region: DHPS; TIGR01496 891968001116 substrate binding pocket [chemical binding]; other site 891968001117 dimer interface [polypeptide binding]; other site 891968001118 inhibitor binding site; inhibition site 891968001119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 891968001120 catalytic core [active] 891968001121 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 891968001122 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 891968001123 GrpE; Region: GrpE; pfam01025 891968001124 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 891968001125 dimer interface [polypeptide binding]; other site 891968001126 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 891968001127 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 891968001128 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 891968001129 nucleotide binding site [chemical binding]; other site 891968001130 NEF interaction site [polypeptide binding]; other site 891968001131 SBD interface [polypeptide binding]; other site 891968001132 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 891968001133 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 891968001134 HSP70 interaction site [polypeptide binding]; other site 891968001135 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 891968001136 Zn binding sites [ion binding]; other site 891968001137 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 891968001138 dimer interface [polypeptide binding]; other site 891968001139 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 891968001140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001141 S-adenosylmethionine binding site [chemical binding]; other site 891968001142 RNA methyltransferase, RsmE family; Region: TIGR00046 891968001143 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 891968001144 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 891968001145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 891968001146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968001147 FeS/SAM binding site; other site 891968001148 Predicted methyltransferases [General function prediction only]; Region: COG1568 891968001149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 891968001150 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 891968001151 nucleotide binding site [chemical binding]; other site 891968001152 putative NEF/HSP70 interaction site [polypeptide binding]; other site 891968001153 SBD interface [polypeptide binding]; other site 891968001154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 891968001155 HSP70 interaction site [polypeptide binding]; other site 891968001156 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 891968001157 nucleotide binding site/active site [active] 891968001158 HIT family signature motif; other site 891968001159 catalytic residue [active] 891968001160 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 891968001161 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 891968001162 ATP cone domain; Region: ATP-cone; pfam03477 891968001163 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 891968001164 ATP cone domain; Region: ATP-cone; pfam03477 891968001165 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 891968001166 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 891968001167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968001168 FeS/SAM binding site; other site 891968001169 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 891968001170 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 891968001171 substrate-cofactor binding pocket; other site 891968001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001173 catalytic residue [active] 891968001174 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 891968001175 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 891968001176 putative ligand binding site [chemical binding]; other site 891968001177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968001178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 891968001179 TM-ABC transporter signature motif; other site 891968001180 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 891968001181 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 891968001182 TM-ABC transporter signature motif; other site 891968001183 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 891968001184 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 891968001185 Walker A/P-loop; other site 891968001186 ATP binding site [chemical binding]; other site 891968001187 Q-loop/lid; other site 891968001188 ABC transporter signature motif; other site 891968001189 Walker B; other site 891968001190 D-loop; other site 891968001191 H-loop/switch region; other site 891968001192 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 891968001193 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 891968001194 Walker A/P-loop; other site 891968001195 ATP binding site [chemical binding]; other site 891968001196 Q-loop/lid; other site 891968001197 ABC transporter signature motif; other site 891968001198 Walker B; other site 891968001199 D-loop; other site 891968001200 H-loop/switch region; other site 891968001201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 891968001202 diaminopimelate aminotransferase; Provisional; Region: PRK13983 891968001203 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 891968001204 metal binding site [ion binding]; metal-binding site 891968001205 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 891968001206 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 891968001207 SEC-C motif; Region: SEC-C; pfam02810 891968001208 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 891968001209 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 891968001210 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 891968001211 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 891968001212 active site 891968001213 HIGH motif; other site 891968001214 KMSK motif region; other site 891968001215 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 891968001216 tRNA binding surface [nucleotide binding]; other site 891968001217 anticodon binding site; other site 891968001218 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 891968001219 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 891968001220 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 891968001221 dimer interface [polypeptide binding]; other site 891968001222 ssDNA binding site [nucleotide binding]; other site 891968001223 tetramer (dimer of dimers) interface [polypeptide binding]; other site 891968001224 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 891968001225 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 891968001226 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 891968001227 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 891968001228 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 891968001229 replicative DNA helicase; Region: DnaB; TIGR00665 891968001230 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 891968001231 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 891968001232 Walker A motif; other site 891968001233 ATP binding site [chemical binding]; other site 891968001234 Walker B motif; other site 891968001235 DNA binding loops [nucleotide binding] 891968001236 Protein of unknown function DUF72; Region: DUF72; pfam01904 891968001237 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 891968001238 active site 891968001239 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 891968001240 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 891968001241 putative ligand binding site [chemical binding]; other site 891968001242 putative NAD binding site [chemical binding]; other site 891968001243 catalytic site [active] 891968001244 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 891968001245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968001246 motif II; other site 891968001247 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 891968001248 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 891968001249 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 891968001250 active site 891968001251 dimer interface [polypeptide binding]; other site 891968001252 effector binding site; other site 891968001253 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 891968001254 TSCPD domain; Region: TSCPD; pfam12637 891968001255 HlyD family secretion protein; Region: HlyD_2; pfam12700 891968001256 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 891968001257 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 891968001258 catalytic residue [active] 891968001259 Protein of unknown function (DUF552); Region: DUF552; pfam04472 891968001260 DivIVA protein; Region: DivIVA; pfam05103 891968001261 DivIVA domain; Region: DivI1A_domain; TIGR03544 891968001262 Y-family of DNA polymerases; Region: PolY; cl12025 891968001263 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 891968001264 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 891968001265 generic binding surface II; other site 891968001266 ssDNA binding site; other site 891968001267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968001268 ATP binding site [chemical binding]; other site 891968001269 putative Mg++ binding site [ion binding]; other site 891968001270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968001271 nucleotide binding region [chemical binding]; other site 891968001272 ATP-binding site [chemical binding]; other site 891968001273 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 891968001274 Na2 binding site [ion binding]; other site 891968001275 putative substrate binding site 1 [chemical binding]; other site 891968001276 Na binding site 1 [ion binding]; other site 891968001277 putative substrate binding site 2 [chemical binding]; other site 891968001278 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 891968001279 Na2 binding site [ion binding]; other site 891968001280 putative substrate binding site 1 [chemical binding]; other site 891968001281 Na binding site 1 [ion binding]; other site 891968001282 putative substrate binding site 2 [chemical binding]; other site 891968001283 phosphodiesterase; Provisional; Region: PRK12704 891968001284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968001285 Zn2+ binding site [ion binding]; other site 891968001286 Mg2+ binding site [ion binding]; other site 891968001287 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 891968001288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968001289 putative active site [active] 891968001290 metal binding site [ion binding]; metal-binding site 891968001291 homodimer binding site [polypeptide binding]; other site 891968001292 HupF/HypC family; Region: HupF_HypC; pfam01455 891968001293 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 891968001294 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 891968001295 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 891968001296 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 891968001297 dimerization interface [polypeptide binding]; other site 891968001298 ATP binding site [chemical binding]; other site 891968001299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968001300 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968001301 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 891968001302 catalytic residues [active] 891968001303 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 891968001304 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 891968001305 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 891968001306 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 891968001307 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 891968001308 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 891968001309 active site 891968001310 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 891968001311 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 891968001312 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 891968001313 alanine racemase; Reviewed; Region: alr; PRK00053 891968001314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 891968001315 active site 891968001316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 891968001317 dimer interface [polypeptide binding]; other site 891968001318 substrate binding site [chemical binding]; other site 891968001319 catalytic residues [active] 891968001320 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 891968001321 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 891968001322 hexamer interface [polypeptide binding]; other site 891968001323 ligand binding site [chemical binding]; other site 891968001324 putative active site [active] 891968001325 NAD(P) binding site [chemical binding]; other site 891968001326 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 891968001327 DEAD-like helicases superfamily; Region: DEXDc; smart00487 891968001328 ATP binding site [chemical binding]; other site 891968001329 Mg++ binding site [ion binding]; other site 891968001330 motif III; other site 891968001331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968001332 nucleotide binding region [chemical binding]; other site 891968001333 ATP-binding site [chemical binding]; other site 891968001334 transketolase; Reviewed; Region: PRK05899 891968001335 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 891968001336 TPP-binding site [chemical binding]; other site 891968001337 dimer interface [polypeptide binding]; other site 891968001338 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 891968001339 PYR/PP interface [polypeptide binding]; other site 891968001340 dimer interface [polypeptide binding]; other site 891968001341 TPP binding site [chemical binding]; other site 891968001342 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968001343 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 891968001344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001345 S-adenosylmethionine binding site [chemical binding]; other site 891968001346 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 891968001347 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 891968001348 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 891968001349 dimerization interface [polypeptide binding]; other site 891968001350 ATP binding site [chemical binding]; other site 891968001351 Rubredoxin [Energy production and conversion]; Region: COG1773 891968001352 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 891968001353 iron binding site [ion binding]; other site 891968001354 threonine synthase; Reviewed; Region: PRK06721 891968001355 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 891968001356 homodimer interface [polypeptide binding]; other site 891968001357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001358 catalytic residue [active] 891968001359 homoserine kinase; Provisional; Region: PRK01212 891968001360 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 891968001361 aspartate kinase; Reviewed; Region: PRK06635 891968001362 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 891968001363 nucleotide binding site [chemical binding]; other site 891968001364 substrate binding site [chemical binding]; other site 891968001365 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 891968001366 putative allosteric regulatory site; other site 891968001367 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 891968001368 putative allosteric regulatory residue; other site 891968001369 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 891968001370 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 891968001371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 891968001372 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 891968001373 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 891968001374 Walker A/P-loop; other site 891968001375 ATP binding site [chemical binding]; other site 891968001376 Q-loop/lid; other site 891968001377 ABC transporter signature motif; other site 891968001378 Walker B; other site 891968001379 D-loop; other site 891968001380 H-loop/switch region; other site 891968001381 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 891968001382 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 891968001383 nickel binding site [ion binding]; other site 891968001384 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 891968001385 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 891968001386 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 891968001387 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 891968001388 dimerization interface [polypeptide binding]; other site 891968001389 domain crossover interface; other site 891968001390 redox-dependent activation switch; other site 891968001391 UGMP family protein; Validated; Region: PRK09604 891968001392 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 891968001393 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 891968001394 oligomerisation interface [polypeptide binding]; other site 891968001395 mobile loop; other site 891968001396 roof hairpin; other site 891968001397 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 891968001398 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 891968001399 ring oligomerisation interface [polypeptide binding]; other site 891968001400 ATP/Mg binding site [chemical binding]; other site 891968001401 stacking interactions; other site 891968001402 hinge regions; other site 891968001403 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 891968001404 AIR carboxylase; Region: AIRC; smart01001 891968001405 ribonuclease R; Region: RNase_R; TIGR02063 891968001406 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 891968001407 RNB domain; Region: RNB; pfam00773 891968001408 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 891968001409 RNA binding site [nucleotide binding]; other site 891968001410 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 891968001411 Domain of unknown function DUF20; Region: UPF0118; pfam01594 891968001412 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 891968001413 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968001414 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 891968001415 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 891968001416 DNA primase; Validated; Region: dnaG; PRK05667 891968001417 CHC2 zinc finger; Region: zf-CHC2; pfam01807 891968001418 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 891968001419 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 891968001420 active site 891968001421 metal binding site [ion binding]; metal-binding site 891968001422 interdomain interaction site; other site 891968001423 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 891968001424 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 891968001425 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 891968001426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 891968001427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 891968001428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 891968001429 DNA binding residues [nucleotide binding] 891968001430 peptide chain release factor 1; Provisional; Region: PRK04011 891968001431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 891968001432 RNA binding surface [nucleotide binding]; other site 891968001433 enolase; Provisional; Region: eno; PRK00077 891968001434 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 891968001435 dimer interface [polypeptide binding]; other site 891968001436 metal binding site [ion binding]; metal-binding site 891968001437 substrate binding pocket [chemical binding]; other site 891968001438 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 891968001439 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 891968001440 CoA binding domain; Region: CoA_binding; pfam02629 891968001441 Preprotein translocase subunit; Region: YajC; pfam02699 891968001442 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 891968001443 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 891968001444 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 891968001445 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 891968001446 Protein export membrane protein; Region: SecD_SecF; pfam02355 891968001447 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 891968001448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968001449 FeS/SAM binding site; other site 891968001450 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 891968001451 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 891968001452 DHH family; Region: DHH; pfam01368 891968001453 DHHA1 domain; Region: DHHA1; pfam02272 891968001454 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 891968001455 putative active site [active] 891968001456 dimerization interface [polypeptide binding]; other site 891968001457 putative tRNAtyr binding site [nucleotide binding]; other site 891968001458 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 891968001459 rod shape-determining protein MreB; Provisional; Region: PRK13927 891968001460 MreB and similar proteins; Region: MreB_like; cd10225 891968001461 nucleotide binding site [chemical binding]; other site 891968001462 Mg binding site [ion binding]; other site 891968001463 putative protofilament interaction site [polypeptide binding]; other site 891968001464 RodZ interaction site [polypeptide binding]; other site 891968001465 rod shape-determining protein MreC; Provisional; Region: PRK13922 891968001466 rod shape-determining protein MreC; Region: MreC; pfam04085 891968001467 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 891968001468 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 891968001469 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 891968001470 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 891968001471 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 891968001472 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 891968001473 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 891968001474 Switch I; other site 891968001475 Switch II; other site 891968001476 Septum formation topological specificity factor MinE; Region: MinE; cl00538 891968001477 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 891968001478 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 891968001479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968001480 FeS/SAM binding site; other site 891968001481 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 891968001482 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 891968001483 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 891968001484 homodimer interface [polypeptide binding]; other site 891968001485 oligonucleotide binding site [chemical binding]; other site 891968001486 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 891968001487 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 891968001488 Walker A/P-loop; other site 891968001489 ATP binding site [chemical binding]; other site 891968001490 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 891968001491 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 891968001492 ABC transporter signature motif; other site 891968001493 Walker B; other site 891968001494 D-loop; other site 891968001495 H-loop/switch region; other site 891968001496 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 891968001497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001498 S-adenosylmethionine binding site [chemical binding]; other site 891968001499 Predicted methyltransferases [General function prediction only]; Region: COG0313 891968001500 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 891968001501 putative SAM binding site [chemical binding]; other site 891968001502 putative homodimer interface [polypeptide binding]; other site 891968001503 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 891968001504 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 891968001505 active site 891968001506 HIGH motif; other site 891968001507 KMSKS motif; other site 891968001508 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 891968001509 tRNA binding surface [nucleotide binding]; other site 891968001510 anticodon binding site; other site 891968001511 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 891968001512 dimer interface [polypeptide binding]; other site 891968001513 putative tRNA-binding site [nucleotide binding]; other site 891968001514 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 891968001515 active site 891968001516 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 891968001517 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 891968001518 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 891968001519 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 891968001520 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 891968001521 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 891968001522 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 891968001523 RPB1 interaction site [polypeptide binding]; other site 891968001524 RPB10 interaction site [polypeptide binding]; other site 891968001525 RPB11 interaction site [polypeptide binding]; other site 891968001526 RPB3 interaction site [polypeptide binding]; other site 891968001527 RPB12 interaction site [polypeptide binding]; other site 891968001528 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 891968001529 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 891968001530 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 891968001531 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 891968001532 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 891968001533 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 891968001534 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 891968001535 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 891968001536 G-loop; other site 891968001537 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 891968001538 DNA binding site [nucleotide binding] 891968001539 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 891968001540 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 891968001541 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 891968001542 S17 interaction site [polypeptide binding]; other site 891968001543 S8 interaction site; other site 891968001544 16S rRNA interaction site [nucleotide binding]; other site 891968001545 streptomycin interaction site [chemical binding]; other site 891968001546 23S rRNA interaction site [nucleotide binding]; other site 891968001547 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 891968001548 30S ribosomal protein S7; Validated; Region: PRK05302 891968001549 elongation factor G; Reviewed; Region: PRK00007 891968001550 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 891968001551 G1 box; other site 891968001552 putative GEF interaction site [polypeptide binding]; other site 891968001553 GTP/Mg2+ binding site [chemical binding]; other site 891968001554 Switch I region; other site 891968001555 G2 box; other site 891968001556 G3 box; other site 891968001557 Switch II region; other site 891968001558 G4 box; other site 891968001559 G5 box; other site 891968001560 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 891968001561 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 891968001562 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 891968001563 elongation factor Tu; Reviewed; Region: PRK00049 891968001564 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 891968001565 G1 box; other site 891968001566 GEF interaction site [polypeptide binding]; other site 891968001567 GTP/Mg2+ binding site [chemical binding]; other site 891968001568 Switch I region; other site 891968001569 G2 box; other site 891968001570 G3 box; other site 891968001571 Switch II region; other site 891968001572 G4 box; other site 891968001573 G5 box; other site 891968001574 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 891968001575 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 891968001576 Antibiotic Binding Site [chemical binding]; other site 891968001577 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 891968001578 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 891968001579 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 891968001580 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 891968001581 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 891968001582 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 891968001583 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 891968001584 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 891968001585 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 891968001586 putative translocon binding site; other site 891968001587 protein-rRNA interface [nucleotide binding]; other site 891968001588 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 891968001589 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 891968001590 G-X-X-G motif; other site 891968001591 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 891968001592 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 891968001593 23S rRNA interface [nucleotide binding]; other site 891968001594 5S rRNA interface [nucleotide binding]; other site 891968001595 putative antibiotic binding site [chemical binding]; other site 891968001596 L25 interface [polypeptide binding]; other site 891968001597 L27 interface [polypeptide binding]; other site 891968001598 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 891968001599 23S rRNA interface [nucleotide binding]; other site 891968001600 putative translocon interaction site; other site 891968001601 signal recognition particle (SRP54) interaction site; other site 891968001602 L23 interface [polypeptide binding]; other site 891968001603 trigger factor interaction site; other site 891968001604 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 891968001605 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 891968001606 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 891968001607 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 891968001608 RNA binding site [nucleotide binding]; other site 891968001609 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 891968001610 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 891968001611 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 891968001612 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 891968001613 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 891968001614 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 891968001615 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 891968001616 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 891968001617 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 891968001618 23S rRNA interface [nucleotide binding]; other site 891968001619 L21e interface [polypeptide binding]; other site 891968001620 5S rRNA interface [nucleotide binding]; other site 891968001621 L27 interface [polypeptide binding]; other site 891968001622 L5 interface [polypeptide binding]; other site 891968001623 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 891968001624 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 891968001625 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 891968001626 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 891968001627 23S rRNA binding site [nucleotide binding]; other site 891968001628 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 891968001629 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 891968001630 SecY translocase; Region: SecY; pfam00344 891968001631 adenylate kinase; Reviewed; Region: adk; PRK00279 891968001632 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 891968001633 AMP-binding site [chemical binding]; other site 891968001634 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 891968001635 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 891968001636 active site 891968001637 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 891968001638 RNA binding site [nucleotide binding]; other site 891968001639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 891968001640 rRNA binding site [nucleotide binding]; other site 891968001641 predicted 30S ribosome binding site; other site 891968001642 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 891968001643 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 891968001644 30S ribosomal protein S13; Region: bact_S13; TIGR03631 891968001645 30S ribosomal protein S11; Validated; Region: PRK05309 891968001646 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 891968001647 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 891968001648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 891968001649 RNA binding surface [nucleotide binding]; other site 891968001650 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 891968001651 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 891968001652 alphaNTD homodimer interface [polypeptide binding]; other site 891968001653 alphaNTD - beta interaction site [polypeptide binding]; other site 891968001654 alphaNTD - beta' interaction site [polypeptide binding]; other site 891968001655 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 891968001656 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 891968001657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 891968001658 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 891968001659 Walker A/P-loop; other site 891968001660 ATP binding site [chemical binding]; other site 891968001661 Q-loop/lid; other site 891968001662 ABC transporter signature motif; other site 891968001663 Walker B; other site 891968001664 D-loop; other site 891968001665 H-loop/switch region; other site 891968001666 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 891968001667 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 891968001668 Walker A/P-loop; other site 891968001669 ATP binding site [chemical binding]; other site 891968001670 Q-loop/lid; other site 891968001671 ABC transporter signature motif; other site 891968001672 Walker B; other site 891968001673 D-loop; other site 891968001674 H-loop/switch region; other site 891968001675 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 891968001676 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 891968001677 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 891968001678 dimerization interface 3.5A [polypeptide binding]; other site 891968001679 active site 891968001680 rod shape-determining protein MreB; Provisional; Region: PRK13927 891968001681 MreB and similar proteins; Region: MreB_like; cd10225 891968001682 nucleotide binding site [chemical binding]; other site 891968001683 Mg binding site [ion binding]; other site 891968001684 putative protofilament interaction site [polypeptide binding]; other site 891968001685 RodZ interaction site [polypeptide binding]; other site 891968001686 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 891968001687 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 891968001688 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 891968001689 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 891968001690 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 891968001691 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 891968001692 SAF-like; Region: SAF_2; pfam13144 891968001693 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 891968001694 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 891968001695 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 891968001696 Flagellar L-ring protein; Region: FlgH; pfam02107 891968001697 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 891968001698 Flagellar P-ring protein; Region: FlgI; pfam02119 891968001699 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 891968001700 L-lysine aminotransferase; Provisional; Region: PRK08297 891968001701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 891968001702 inhibitor-cofactor binding pocket; inhibition site 891968001703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001704 catalytic residue [active] 891968001705 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 891968001706 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 891968001707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 891968001708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 891968001709 Coenzyme A binding pocket [chemical binding]; other site 891968001710 S-adenosylmethionine synthetase; Validated; Region: PRK05250 891968001711 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 891968001712 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 891968001713 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 891968001714 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 891968001715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968001716 active site 891968001717 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 891968001718 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 891968001719 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 891968001720 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 891968001721 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 891968001722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 891968001723 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 891968001724 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 891968001725 FlaG protein; Region: FlaG; pfam03646 891968001726 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 891968001727 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968001728 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 891968001729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 891968001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001731 S-adenosylmethionine binding site [chemical binding]; other site 891968001732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968001733 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 891968001734 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 891968001735 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 891968001736 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 891968001737 NAD(P) binding site [chemical binding]; other site 891968001738 homodimer interface [polypeptide binding]; other site 891968001739 substrate binding site [chemical binding]; other site 891968001740 active site 891968001741 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 891968001742 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 891968001743 inhibitor-cofactor binding pocket; inhibition site 891968001744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001745 catalytic residue [active] 891968001746 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 891968001747 ligand binding site; other site 891968001748 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 891968001749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968001750 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 891968001751 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 891968001752 pseudaminic acid synthase; Region: PseI; TIGR03586 891968001753 NeuB family; Region: NeuB; pfam03102 891968001754 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 891968001755 NeuB binding interface [polypeptide binding]; other site 891968001756 putative substrate binding site [chemical binding]; other site 891968001757 YcfA-like protein; Region: YcfA; pfam07927 891968001758 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 891968001759 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 891968001760 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 891968001761 Mechanosensitive ion channel; Region: MS_channel; pfam00924 891968001762 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 891968001763 active site 891968001764 NTP binding site [chemical binding]; other site 891968001765 metal binding triad [ion binding]; metal-binding site 891968001766 antibiotic binding site [chemical binding]; other site 891968001767 HEPN domain; Region: HEPN; pfam05168 891968001768 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 891968001769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968001770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968001771 homodimer interface [polypeptide binding]; other site 891968001772 catalytic residue [active] 891968001773 D-glutamate deacylase; Validated; Region: PRK09061 891968001774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968001775 active site 891968001776 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 891968001777 active site 891968001778 intersubunit interface [polypeptide binding]; other site 891968001779 zinc binding site [ion binding]; other site 891968001780 Na+ binding site [ion binding]; other site 891968001781 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 891968001782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 891968001783 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 891968001784 Bacitracin resistance protein BacA; Region: BacA; pfam02673 891968001785 Maf-like protein; Provisional; Region: PRK14361 891968001786 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 891968001787 active site 891968001788 dimer interface [polypeptide binding]; other site 891968001789 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 891968001790 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 891968001791 transketolase; Reviewed; Region: PRK05899 891968001792 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 891968001793 TPP-binding site [chemical binding]; other site 891968001794 dimer interface [polypeptide binding]; other site 891968001795 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 891968001796 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 891968001797 PYR/PP interface [polypeptide binding]; other site 891968001798 dimer interface [polypeptide binding]; other site 891968001799 TPP binding site [chemical binding]; other site 891968001800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968001801 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 891968001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968001803 Walker A/P-loop; other site 891968001804 ATP binding site [chemical binding]; other site 891968001805 Q-loop/lid; other site 891968001806 ABC transporter signature motif; other site 891968001807 Walker B; other site 891968001808 D-loop; other site 891968001809 H-loop/switch region; other site 891968001810 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 891968001811 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 891968001812 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 891968001813 Peptidase family M23; Region: Peptidase_M23; pfam01551 891968001814 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 891968001815 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 891968001816 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 891968001817 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 891968001818 Catalytic dyad [active] 891968001819 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 891968001820 NodB motif; other site 891968001821 putative active site [active] 891968001822 putative catalytic site [active] 891968001823 Zn binding site [ion binding]; other site 891968001824 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 891968001825 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 891968001826 GDP-binding site [chemical binding]; other site 891968001827 ACT binding site; other site 891968001828 IMP binding site; other site 891968001829 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 891968001830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968001831 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 891968001832 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 891968001833 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 891968001834 putative active site [active] 891968001835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968001836 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 891968001837 putative glycosyl transferase; Provisional; Region: PRK10073 891968001838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 891968001839 active site 891968001840 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 891968001841 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 891968001842 putative active site [active] 891968001843 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 891968001844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968001845 S-layer homology domain; Region: SLH; pfam00395 891968001846 Predicted coiled-coil protein (DUF2205); Region: DUF2205; pfam10224 891968001847 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 891968001848 6-phosphofructokinase; Provisional; Region: PRK03202 891968001849 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 891968001850 active site 891968001851 ADP/pyrophosphate binding site [chemical binding]; other site 891968001852 dimerization interface [polypeptide binding]; other site 891968001853 allosteric effector site; other site 891968001854 fructose-1,6-bisphosphate binding site; other site 891968001855 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 891968001856 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 891968001857 MoaE interaction surface [polypeptide binding]; other site 891968001858 MoeB interaction surface [polypeptide binding]; other site 891968001859 thiocarboxylated glycine; other site 891968001860 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 891968001861 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 891968001862 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 891968001863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968001864 active site 891968001865 motif I; other site 891968001866 motif II; other site 891968001867 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 891968001868 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 891968001869 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 891968001870 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 891968001871 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 891968001872 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 891968001873 metal binding site [ion binding]; metal-binding site 891968001874 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 891968001875 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 891968001876 substrate binding site [chemical binding]; other site 891968001877 glutamase interaction surface [polypeptide binding]; other site 891968001878 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 891968001879 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 891968001880 catalytic residues [active] 891968001881 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 891968001882 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 891968001883 putative active site [active] 891968001884 oxyanion strand; other site 891968001885 catalytic triad [active] 891968001886 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 891968001887 putative active site pocket [active] 891968001888 4-fold oligomerization interface [polypeptide binding]; other site 891968001889 metal binding residues [ion binding]; metal-binding site 891968001890 3-fold/trimer interface [polypeptide binding]; other site 891968001891 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 891968001892 ATP phosphoribosyltransferase; Region: HisG; cl15266 891968001893 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 891968001894 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 891968001895 active site 891968001896 dimer interface [polypeptide binding]; other site 891968001897 motif 2; other site 891968001898 motif 3; other site 891968001899 DNA repair protein RadA; Provisional; Region: PRK11823 891968001900 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 891968001901 Walker A motif; other site 891968001902 ATP binding site [chemical binding]; other site 891968001903 Walker B motif; other site 891968001904 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 891968001905 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 891968001906 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 891968001907 dimer interface [polypeptide binding]; other site 891968001908 active site residues [active] 891968001909 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 891968001910 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 891968001911 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 891968001912 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 891968001913 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 891968001914 HIGH motif; other site 891968001915 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 891968001916 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 891968001917 active site 891968001918 KMSKS motif; other site 891968001919 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 891968001920 tRNA binding surface [nucleotide binding]; other site 891968001921 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 891968001922 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 891968001923 Protein of unknown function (DUF445); Region: DUF445; pfam04286 891968001924 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 891968001925 Ribonuclease P; Region: Ribonuclease_P; pfam00825 891968001926 Haemolytic domain; Region: Haemolytic; pfam01809 891968001927 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 891968001928 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 891968001929 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 891968001930 G-X-X-G motif; other site 891968001931 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 891968001932 RxxxH motif; other site 891968001933 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 891968001934 16S/18S rRNA binding site [nucleotide binding]; other site 891968001935 S13e-L30e interaction site [polypeptide binding]; other site 891968001936 25S rRNA binding site [nucleotide binding]; other site 891968001937 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 891968001938 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 891968001939 RNase E interface [polypeptide binding]; other site 891968001940 trimer interface [polypeptide binding]; other site 891968001941 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 891968001942 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 891968001943 RNase E interface [polypeptide binding]; other site 891968001944 trimer interface [polypeptide binding]; other site 891968001945 active site 891968001946 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 891968001947 putative nucleic acid binding region [nucleotide binding]; other site 891968001948 G-X-X-G motif; other site 891968001949 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 891968001950 RNA binding site [nucleotide binding]; other site 891968001951 domain interface; other site 891968001952 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 891968001953 trimer interface [polypeptide binding]; other site 891968001954 active site 891968001955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001956 S-adenosylmethionine binding site [chemical binding]; other site 891968001957 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 891968001958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968001959 S-adenosylmethionine binding site [chemical binding]; other site 891968001960 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 891968001961 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 891968001962 active site 891968001963 (T/H)XGH motif; other site 891968001964 hypothetical protein; Provisional; Region: PRK13670 891968001965 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 891968001966 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 891968001967 propionate/acetate kinase; Provisional; Region: PRK12379 891968001968 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 891968001969 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 891968001970 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 891968001971 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 891968001972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 891968001973 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 891968001974 active site 2 [active] 891968001975 putative phosphate acyltransferase; Provisional; Region: PRK05331 891968001976 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 891968001977 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 891968001978 dimer interface [polypeptide binding]; other site 891968001979 active site 891968001980 CoA binding pocket [chemical binding]; other site 891968001981 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 891968001982 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 891968001983 FMN binding site [chemical binding]; other site 891968001984 substrate binding site [chemical binding]; other site 891968001985 putative catalytic residue [active] 891968001986 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 891968001987 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 891968001988 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 891968001989 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 891968001990 NAD(P) binding site [chemical binding]; other site 891968001991 homotetramer interface [polypeptide binding]; other site 891968001992 homodimer interface [polypeptide binding]; other site 891968001993 active site 891968001994 acyl carrier protein; Provisional; Region: acpP; PRK00982 891968001995 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 891968001996 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 891968001997 dimer interface [polypeptide binding]; other site 891968001998 active site 891968001999 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 891968002000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968002001 active site 891968002002 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 891968002003 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 891968002004 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 891968002005 dihydroorotase; Validated; Region: pyrC; PRK09357 891968002006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968002007 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 891968002008 active site 891968002009 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 891968002010 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 891968002011 FAD binding pocket [chemical binding]; other site 891968002012 conserved FAD binding motif [chemical binding]; other site 891968002013 phosphate binding motif [ion binding]; other site 891968002014 beta-alpha-beta structure motif; other site 891968002015 NAD binding pocket [chemical binding]; other site 891968002016 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 891968002017 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 891968002018 heterodimer interface [polypeptide binding]; other site 891968002019 active site 891968002020 FMN binding site [chemical binding]; other site 891968002021 homodimer interface [polypeptide binding]; other site 891968002022 substrate binding site [chemical binding]; other site 891968002023 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 891968002024 active site 891968002025 dimer interface [polypeptide binding]; other site 891968002026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968002027 active site 891968002028 selenophosphate synthetase; Provisional; Region: PRK00943 891968002029 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 891968002030 dimerization interface [polypeptide binding]; other site 891968002031 putative ATP binding site [chemical binding]; other site 891968002032 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 891968002033 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 891968002034 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 891968002035 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 891968002036 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 891968002037 Permease; Region: Permease; pfam02405 891968002038 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 891968002039 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 891968002040 Walker A/P-loop; other site 891968002041 ATP binding site [chemical binding]; other site 891968002042 Q-loop/lid; other site 891968002043 ABC transporter signature motif; other site 891968002044 Walker B; other site 891968002045 D-loop; other site 891968002046 H-loop/switch region; other site 891968002047 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 891968002048 mce related protein; Region: MCE; pfam02470 891968002049 thymidylate kinase; Validated; Region: tmk; PRK00698 891968002050 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 891968002051 TMP-binding site; other site 891968002052 ATP-binding site [chemical binding]; other site 891968002053 Protein of unknown function (DUF327); Region: DUF327; pfam03885 891968002054 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 891968002055 DNA polymerase III subunit delta'; Validated; Region: PRK08485 891968002056 PSP1 C-terminal conserved region; Region: PSP1; cl00770 891968002057 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 891968002058 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 891968002059 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 891968002060 P loop; other site 891968002061 GTP binding site [chemical binding]; other site 891968002062 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 891968002063 adenylosuccinate lyase; Provisional; Region: PRK07492 891968002064 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 891968002065 tetramer interface [polypeptide binding]; other site 891968002066 active site 891968002067 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 891968002068 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 891968002069 putative active site [active] 891968002070 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 891968002071 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 891968002072 Potassium binding sites [ion binding]; other site 891968002073 Cesium cation binding sites [ion binding]; other site 891968002074 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 891968002075 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 891968002076 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 891968002077 hexamer interface [polypeptide binding]; other site 891968002078 RNA binding site [nucleotide binding]; other site 891968002079 Histidine-zinc binding site [chemical binding]; other site 891968002080 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 891968002081 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 891968002082 peptide chain release factor 1; Validated; Region: prfA; PRK00591 891968002083 This domain is found in peptide chain release factors; Region: PCRF; smart00937 891968002084 RF-1 domain; Region: RF-1; pfam00472 891968002085 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 891968002086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968002087 S-adenosylmethionine binding site [chemical binding]; other site 891968002088 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 891968002089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 891968002090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968002091 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 891968002092 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 891968002093 putative substrate binding site [chemical binding]; other site 891968002094 putative ATP binding site [chemical binding]; other site 891968002095 FOG: CBS domain [General function prediction only]; Region: COG0517 891968002096 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 891968002097 Low molecular weight phosphatase family; Region: LMWPc; cl00105 891968002098 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 891968002099 active site 891968002100 Flagellar protein FliS; Region: FliS; cl00654 891968002101 FlgN protein; Region: FlgN; pfam05130 891968002102 Peptidase family M48; Region: Peptidase_M48; pfam01435 891968002103 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 891968002104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968002105 Walker A motif; other site 891968002106 ATP binding site [chemical binding]; other site 891968002107 Walker B motif; other site 891968002108 arginine finger; other site 891968002109 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 891968002110 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 891968002111 active site 891968002112 PHP Thumb interface [polypeptide binding]; other site 891968002113 metal binding site [ion binding]; metal-binding site 891968002114 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 891968002115 generic binding surface II; other site 891968002116 generic binding surface I; other site 891968002117 pyruvate kinase; Provisional; Region: PRK06354 891968002118 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 891968002119 domain interfaces; other site 891968002120 active site 891968002121 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 891968002122 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 891968002123 putative active site [active] 891968002124 putative CoA binding site [chemical binding]; other site 891968002125 nudix motif; other site 891968002126 metal binding site [ion binding]; metal-binding site 891968002127 endonuclease IV; Provisional; Region: PRK01060 891968002128 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 891968002129 AP (apurinic/apyrimidinic) site pocket; other site 891968002130 DNA interaction; other site 891968002131 Metal-binding active site; metal-binding site 891968002132 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 891968002133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 891968002134 dimer interface [polypeptide binding]; other site 891968002135 active site 891968002136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 891968002137 substrate binding site [chemical binding]; other site 891968002138 catalytic residue [active] 891968002139 TIGR00159 family protein; Region: TIGR00159 891968002140 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 891968002141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 891968002142 YbbR-like protein; Region: YbbR; pfam07949 891968002143 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 891968002144 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 891968002145 active site 891968002146 substrate binding site [chemical binding]; other site 891968002147 metal binding site [ion binding]; metal-binding site 891968002148 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 891968002149 active site 891968002150 tetramer interface; other site 891968002151 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 891968002152 metal binding site 2 [ion binding]; metal-binding site 891968002153 putative DNA binding helix; other site 891968002154 metal binding site 1 [ion binding]; metal-binding site 891968002155 dimer interface [polypeptide binding]; other site 891968002156 structural Zn2+ binding site [ion binding]; other site 891968002157 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 891968002158 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 891968002159 Substrate binding site; other site 891968002160 Mg++ binding site; other site 891968002161 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 891968002162 active site 891968002163 substrate binding site [chemical binding]; other site 891968002164 CoA binding site [chemical binding]; other site 891968002165 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 891968002166 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 891968002167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968002168 active site 891968002169 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 891968002170 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 891968002171 5S rRNA interface [nucleotide binding]; other site 891968002172 CTC domain interface [polypeptide binding]; other site 891968002173 L16 interface [polypeptide binding]; other site 891968002174 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 891968002175 putative active site [active] 891968002176 catalytic residue [active] 891968002177 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 891968002178 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 891968002179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968002180 ATP binding site [chemical binding]; other site 891968002181 putative Mg++ binding site [ion binding]; other site 891968002182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968002183 nucleotide binding region [chemical binding]; other site 891968002184 ATP-binding site [chemical binding]; other site 891968002185 TRCF domain; Region: TRCF; pfam03461 891968002186 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 891968002187 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 891968002188 homodimer interface [polypeptide binding]; other site 891968002189 metal binding site [ion binding]; metal-binding site 891968002190 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 891968002191 homodimer interface [polypeptide binding]; other site 891968002192 active site 891968002193 putative chemical substrate binding site [chemical binding]; other site 891968002194 metal binding site [ion binding]; metal-binding site 891968002195 oxaloacetate decarboxylase; Provisional; Region: PRK12331 891968002196 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 891968002197 active site 891968002198 catalytic residues [active] 891968002199 metal binding site [ion binding]; metal-binding site 891968002200 homodimer binding site [polypeptide binding]; other site 891968002201 NifU-like domain; Region: NifU; cl00484 891968002202 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 891968002203 PhoH-like protein; Region: PhoH; pfam02562 891968002204 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 891968002205 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 891968002206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968002207 Zn2+ binding site [ion binding]; other site 891968002208 Mg2+ binding site [ion binding]; other site 891968002209 metal-binding heat shock protein; Provisional; Region: PRK00016 891968002210 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 891968002211 Domain of unknown function DUF21; Region: DUF21; pfam01595 891968002212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 891968002213 Transporter associated domain; Region: CorC_HlyC; smart01091 891968002214 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 891968002215 Recombination protein O C terminal; Region: RecO_C; pfam02565 891968002216 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 891968002217 dimer interface [polypeptide binding]; other site 891968002218 motif 1; other site 891968002219 active site 891968002220 motif 2; other site 891968002221 motif 3; other site 891968002222 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 891968002223 DALR anticodon binding domain; Region: DALR_1; pfam05746 891968002224 anticodon binding site; other site 891968002225 tRNA binding surface [nucleotide binding]; other site 891968002226 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 891968002227 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 891968002228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968002229 Zn2+ binding site [ion binding]; other site 891968002230 Mg2+ binding site [ion binding]; other site 891968002231 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 891968002232 Transglycosylase; Region: Transgly; pfam00912 891968002233 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 891968002234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 891968002235 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 891968002236 spermidine synthase; Provisional; Region: PRK00811 891968002237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 891968002238 agmatinase; Region: agmatinase; TIGR01230 891968002239 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 891968002240 putative active site [active] 891968002241 Mn binding site [ion binding]; other site 891968002242 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 891968002243 Amidinotransferase; Region: Amidinotransf; cl12043 891968002244 ornithine carbamoyltransferase; Validated; Region: PRK02102 891968002245 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 891968002246 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 891968002247 nickel responsive regulator; Provisional; Region: PRK01002 891968002248 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 891968002249 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 891968002250 NAD synthetase; Provisional; Region: PRK13980 891968002251 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 891968002252 homodimer interface [polypeptide binding]; other site 891968002253 NAD binding pocket [chemical binding]; other site 891968002254 ATP binding pocket [chemical binding]; other site 891968002255 Mg binding site [ion binding]; other site 891968002256 active-site loop [active] 891968002257 hypothetical protein; Validated; Region: PRK00110 891968002258 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 891968002259 active site 891968002260 putative DNA-binding cleft [nucleotide binding]; other site 891968002261 dimer interface [polypeptide binding]; other site 891968002262 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 891968002263 RuvA N terminal domain; Region: RuvA_N; pfam01330 891968002264 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 891968002265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968002266 Walker A motif; other site 891968002267 ATP binding site [chemical binding]; other site 891968002268 Walker B motif; other site 891968002269 arginine finger; other site 891968002270 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 891968002271 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 891968002272 Stage II sporulation protein; Region: SpoIID; pfam08486 891968002273 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 891968002274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 891968002275 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 891968002276 hypothetical protein; Provisional; Region: PRK03881 891968002277 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 891968002278 AMMECR1; Region: AMMECR1; pfam01871 891968002279 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 891968002280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968002281 FeS/SAM binding site; other site 891968002282 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 891968002283 active sites [active] 891968002284 tetramer interface [polypeptide binding]; other site 891968002285 glutamate formiminotransferase; Region: FtcD; TIGR02024 891968002286 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 891968002287 Formiminotransferase domain; Region: FTCD; pfam02971 891968002288 imidazolonepropionase; Validated; Region: PRK09356 891968002289 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 891968002290 active site 891968002291 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 891968002292 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 891968002293 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 891968002294 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 891968002295 putative substrate binding site [chemical binding]; other site 891968002296 putative ATP binding site [chemical binding]; other site 891968002297 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 891968002298 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 891968002299 Glycoprotease family; Region: Peptidase_M22; pfam00814 891968002300 Ferredoxin [Energy production and conversion]; Region: COG1146 891968002301 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 891968002302 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 891968002303 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968002304 dimer interface [polypeptide binding]; other site 891968002305 PYR/PP interface [polypeptide binding]; other site 891968002306 TPP binding site [chemical binding]; other site 891968002307 substrate binding site [chemical binding]; other site 891968002308 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 891968002309 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 891968002310 TPP-binding site [chemical binding]; other site 891968002311 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 891968002312 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 891968002313 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 891968002314 TRAM domain; Region: TRAM; cl01282 891968002315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968002316 S-adenosylmethionine binding site [chemical binding]; other site 891968002317 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 891968002318 4Fe-4S binding domain; Region: Fer4; pfam00037 891968002319 4Fe-4S binding domain; Region: Fer4_6; pfam12837 891968002320 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 891968002321 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 891968002322 DNA binding residues [nucleotide binding] 891968002323 putative dimer interface [polypeptide binding]; other site 891968002324 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 891968002325 HsdM N-terminal domain; Region: HsdM_N; pfam12161 891968002326 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 891968002327 Methyltransferase domain; Region: Methyltransf_26; pfam13659 891968002328 Divergent AAA domain; Region: AAA_4; pfam04326 891968002329 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 891968002330 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 891968002331 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 891968002332 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 891968002333 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 891968002334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968002335 ATP binding site [chemical binding]; other site 891968002336 putative Mg++ binding site [ion binding]; other site 891968002337 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 891968002338 Protein of unknown function DUF45; Region: DUF45; pfam01863 891968002339 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 891968002340 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 891968002341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 891968002342 non-specific DNA binding site [nucleotide binding]; other site 891968002343 salt bridge; other site 891968002344 sequence-specific DNA binding site [nucleotide binding]; other site 891968002345 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 891968002346 polymerase nucleotide-binding site; other site 891968002347 DNA-binding residues [nucleotide binding]; DNA binding site 891968002348 nucleotide binding site [chemical binding]; other site 891968002349 primase nucleotide-binding site [nucleotide binding]; other site 891968002350 D5 N terminal like; Region: D5_N; smart00885 891968002351 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 891968002352 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 891968002353 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 891968002354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 891968002355 active site 891968002356 DNA binding site [nucleotide binding] 891968002357 Int/Topo IB signature motif; other site 891968002358 trigger factor; Provisional; Region: tig; PRK01490 891968002359 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 891968002360 Clp protease; Region: CLP_protease; pfam00574 891968002361 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 891968002362 oligomer interface [polypeptide binding]; other site 891968002363 active site residues [active] 891968002364 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 891968002365 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 891968002366 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 891968002367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968002368 Walker A motif; other site 891968002369 ATP binding site [chemical binding]; other site 891968002370 Walker B motif; other site 891968002371 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 891968002372 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 891968002373 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 891968002374 HIGH motif; other site 891968002375 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 891968002376 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 891968002377 active site 891968002378 KMSKS motif; other site 891968002379 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 891968002380 tRNA binding surface [nucleotide binding]; other site 891968002381 anticodon binding site; other site 891968002382 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 891968002383 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 891968002384 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968002385 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 891968002386 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 891968002387 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 891968002388 PQQ-like domain; Region: PQQ_2; pfam13360 891968002389 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 891968002390 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 891968002391 Walker A; other site 891968002392 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 891968002393 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 891968002394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968002395 active site 891968002396 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 891968002397 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 891968002398 Mg++ binding site [ion binding]; other site 891968002399 putative catalytic motif [active] 891968002400 substrate binding site [chemical binding]; other site 891968002401 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 891968002402 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 891968002403 active site 891968002404 homodimer interface [polypeptide binding]; other site 891968002405 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 891968002406 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 891968002407 hinge; other site 891968002408 active site 891968002409 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 891968002410 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968002411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968002412 homodimer interface [polypeptide binding]; other site 891968002413 catalytic residue [active] 891968002414 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 891968002415 Fe-S cluster binding site [ion binding]; other site 891968002416 active site 891968002417 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 891968002418 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 891968002419 catalytic residue [active] 891968002420 putative FPP diphosphate binding site; other site 891968002421 putative FPP binding hydrophobic cleft; other site 891968002422 dimer interface [polypeptide binding]; other site 891968002423 putative IPP diphosphate binding site; other site 891968002424 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 891968002425 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 891968002426 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 891968002427 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 891968002428 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 891968002429 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 891968002430 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 891968002431 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 891968002432 active site 891968002433 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 891968002434 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 891968002435 GcpE protein; Region: GcpE; pfam04551 891968002436 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 891968002437 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 891968002438 elongation factor P; Validated; Region: PRK00529 891968002439 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 891968002440 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 891968002441 RNA binding site [nucleotide binding]; other site 891968002442 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 891968002443 RNA binding site [nucleotide binding]; other site 891968002444 Asp23 family; Region: Asp23; pfam03780 891968002445 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 891968002446 putative RNA binding site [nucleotide binding]; other site 891968002447 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 891968002448 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 891968002449 generic binding surface II; other site 891968002450 generic binding surface I; other site 891968002451 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 891968002452 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 891968002453 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 891968002454 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 891968002455 homotetramer interface [polypeptide binding]; other site 891968002456 ligand binding site [chemical binding]; other site 891968002457 catalytic site [active] 891968002458 NAD binding site [chemical binding]; other site 891968002459 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 891968002460 N-ethylammeline chlorohydrolase; Provisional; Region: PRK08393 891968002461 active site 891968002462 putative substrate binding pocket [chemical binding]; other site 891968002463 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 891968002464 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 891968002465 motif 1; other site 891968002466 active site 891968002467 motif 2; other site 891968002468 motif 3; other site 891968002469 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 891968002470 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 891968002471 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 891968002472 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 891968002473 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 891968002474 LytB protein; Region: LYTB; cl00507 891968002475 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 891968002476 RNA binding site [nucleotide binding]; other site 891968002477 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 891968002478 RNA binding site [nucleotide binding]; other site 891968002479 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 891968002480 RNA binding site [nucleotide binding]; other site 891968002481 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 891968002482 RNA binding site [nucleotide binding]; other site 891968002483 domain interface; other site 891968002484 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 891968002485 active site 891968002486 catalytic residues [active] 891968002487 metal binding site [ion binding]; metal-binding site 891968002488 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 891968002489 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 891968002490 substrate binding site [chemical binding]; other site 891968002491 putative active site [active] 891968002492 putative cosubstrate binding site; other site 891968002493 catalytic site [active] 891968002494 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 891968002495 substrate binding site [chemical binding]; other site 891968002496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 891968002497 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 891968002498 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968002499 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 891968002500 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968002501 dimer interface [polypeptide binding]; other site 891968002502 PYR/PP interface [polypeptide binding]; other site 891968002503 TPP binding site [chemical binding]; other site 891968002504 substrate binding site [chemical binding]; other site 891968002505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968002506 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 891968002507 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 891968002508 TPP-binding site [chemical binding]; other site 891968002509 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 891968002510 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 891968002511 dimer interface [polypeptide binding]; other site 891968002512 ADP-ribose binding site [chemical binding]; other site 891968002513 active site 891968002514 nudix motif; other site 891968002515 metal binding site [ion binding]; metal-binding site 891968002516 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 891968002517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 891968002518 active site 891968002519 DNA binding site [nucleotide binding] 891968002520 Int/Topo IB signature motif; other site 891968002521 phosphopentomutase; Provisional; Region: PRK05362 891968002522 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 891968002523 purine nucleoside phosphorylase; Provisional; Region: PRK08202 891968002524 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 891968002525 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 891968002526 ATP binding site [chemical binding]; other site 891968002527 substrate interface [chemical binding]; other site 891968002528 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 891968002529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 891968002530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 891968002531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 891968002532 DNA binding residues [nucleotide binding] 891968002533 dimerization interface [polypeptide binding]; other site 891968002534 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 891968002535 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 891968002536 active site 891968002537 HIGH motif; other site 891968002538 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 891968002539 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 891968002540 KMSKS motif; other site 891968002541 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 891968002542 tRNA binding surface [nucleotide binding]; other site 891968002543 anticodon binding site; other site 891968002544 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 891968002545 GIY-YIG motif/motif A; other site 891968002546 active site 891968002547 catalytic site [active] 891968002548 putative DNA binding site [nucleotide binding]; other site 891968002549 metal binding site [ion binding]; metal-binding site 891968002550 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 891968002551 Y-family of DNA polymerases; Region: PolY; cl12025 891968002552 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 891968002553 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 891968002554 catalytic motif [active] 891968002555 Zn binding site [ion binding]; other site 891968002556 RibD C-terminal domain; Region: RibD_C; cl17279 891968002557 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 891968002558 Lumazine binding domain; Region: Lum_binding; pfam00677 891968002559 Lumazine binding domain; Region: Lum_binding; pfam00677 891968002560 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 891968002561 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 891968002562 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 891968002563 dimerization interface [polypeptide binding]; other site 891968002564 active site 891968002565 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 891968002566 homopentamer interface [polypeptide binding]; other site 891968002567 active site 891968002568 seryl-tRNA synthetase; Provisional; Region: PRK05431 891968002569 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 891968002570 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 891968002571 dimer interface [polypeptide binding]; other site 891968002572 active site 891968002573 motif 1; other site 891968002574 motif 2; other site 891968002575 motif 3; other site 891968002576 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 891968002577 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 891968002578 putative catalytic motif [active] 891968002579 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 891968002580 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 891968002581 FOG: CBS domain [General function prediction only]; Region: COG0517 891968002582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 891968002583 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 891968002584 V-type ATP synthase subunit I; Validated; Region: PRK05771 891968002585 ATP synthase subunit C; Region: ATP-synt_C; cl00466 891968002586 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 891968002587 V-type ATP synthase subunit A; Provisional; Region: PRK04192 891968002588 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968002589 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 891968002590 Walker A motif/ATP binding site; other site 891968002591 Walker B motif; other site 891968002592 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968002593 V-type ATP synthase subunit B; Provisional; Region: PRK04196 891968002594 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968002595 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 891968002596 Walker A motif homologous position; other site 891968002597 Walker B motif; other site 891968002598 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968002599 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 891968002600 hypothetical protein; Validated; Region: PRK00153 891968002601 recombination protein RecR; Reviewed; Region: recR; PRK00076 891968002602 RecR protein; Region: RecR; pfam02132 891968002603 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 891968002604 putative active site [active] 891968002605 putative metal-binding site [ion binding]; other site 891968002606 tetramer interface [polypeptide binding]; other site 891968002607 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 891968002608 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 891968002609 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 891968002610 putative active site [active] 891968002611 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 891968002612 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 891968002613 substrate binding site; other site 891968002614 dimer interface; other site 891968002615 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 891968002616 homotrimer interaction site [polypeptide binding]; other site 891968002617 zinc binding site [ion binding]; other site 891968002618 CDP-binding sites; other site 891968002619 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 891968002620 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 891968002621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 891968002622 active site 891968002623 HIGH motif; other site 891968002624 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 891968002625 active site 891968002626 KMSKS motif; other site 891968002627 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 891968002628 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 891968002629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 891968002630 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 891968002631 active site 891968002632 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 891968002633 DNA-binding site [nucleotide binding]; DNA binding site 891968002634 RNA-binding motif; other site 891968002635 Acylphosphatase; Region: Acylphosphatase; pfam00708 891968002636 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 891968002637 HypF finger; Region: zf-HYPF; pfam07503 891968002638 HypF finger; Region: zf-HYPF; pfam07503 891968002639 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 891968002640 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 891968002641 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 891968002642 homodimer interface [polypeptide binding]; other site 891968002643 Walker A motif; other site 891968002644 ATP binding site [chemical binding]; other site 891968002645 hydroxycobalamin binding site [chemical binding]; other site 891968002646 Walker B motif; other site 891968002647 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 891968002648 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 891968002649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 891968002650 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 891968002651 Soluble P-type ATPase [General function prediction only]; Region: COG4087 891968002652 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 891968002653 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 891968002654 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 891968002655 Ligand Binding Site [chemical binding]; other site 891968002656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968002657 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968002658 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 891968002659 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 891968002660 minor groove reading motif; other site 891968002661 helix-hairpin-helix signature motif; other site 891968002662 substrate binding pocket [chemical binding]; other site 891968002663 active site 891968002664 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 891968002665 Uncharacterized conserved protein [Function unknown]; Region: COG2006 891968002666 Domain of unknown function (DUF362); Region: DUF362; pfam04015 891968002667 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 891968002668 4Fe-4S binding domain; Region: Fer4; pfam00037 891968002669 Trp repressor protein; Region: Trp_repressor; cl17266 891968002670 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 891968002671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968002672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968002673 homodimer interface [polypeptide binding]; other site 891968002674 catalytic residue [active] 891968002675 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 891968002676 putative amphipathic alpha helix; other site 891968002677 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 891968002678 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 891968002679 Ligand Binding Site [chemical binding]; other site 891968002680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968002681 active site 891968002682 FtsH Extracellular; Region: FtsH_ext; pfam06480 891968002683 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 891968002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968002685 Walker A motif; other site 891968002686 ATP binding site [chemical binding]; other site 891968002687 Walker B motif; other site 891968002688 arginine finger; other site 891968002689 Peptidase family M41; Region: Peptidase_M41; pfam01434 891968002690 excinuclease ABC subunit B; Provisional; Region: PRK05298 891968002691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968002692 ATP binding site [chemical binding]; other site 891968002693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968002694 nucleotide binding region [chemical binding]; other site 891968002695 ATP-binding site [chemical binding]; other site 891968002696 Ultra-violet resistance protein B; Region: UvrB; pfam12344 891968002697 UvrB/uvrC motif; Region: UVR; pfam02151 891968002698 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 891968002699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 891968002700 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 891968002701 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 891968002702 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 891968002703 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 891968002704 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 891968002705 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 891968002706 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 891968002707 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 891968002708 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 891968002709 Thiamine pyrophosphokinase; Region: TPK; cd07995 891968002710 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 891968002711 active site 891968002712 dimerization interface [polypeptide binding]; other site 891968002713 thiamine binding site [chemical binding]; other site 891968002714 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 891968002715 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 891968002716 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 891968002717 substrate binding pocket [chemical binding]; other site 891968002718 chain length determination region; other site 891968002719 substrate-Mg2+ binding site; other site 891968002720 catalytic residues [active] 891968002721 aspartate-rich region 1; other site 891968002722 active site lid residues [active] 891968002723 aspartate-rich region 2; other site 891968002724 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 891968002725 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 891968002726 TPP-binding site; other site 891968002727 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 891968002728 PYR/PP interface [polypeptide binding]; other site 891968002729 dimer interface [polypeptide binding]; other site 891968002730 TPP binding site [chemical binding]; other site 891968002731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968002732 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 891968002733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968002734 S-adenosylmethionine binding site [chemical binding]; other site 891968002735 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 891968002736 ATP-NAD kinase; Region: NAD_kinase; pfam01513 891968002737 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 891968002738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968002739 Walker A/P-loop; other site 891968002740 ATP binding site [chemical binding]; other site 891968002741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968002742 ABC transporter signature motif; other site 891968002743 Walker B; other site 891968002744 D-loop; other site 891968002745 H-loop/switch region; other site 891968002746 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 891968002747 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 891968002748 Protein of unknown function (DUF464); Region: DUF464; pfam04327 891968002749 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 891968002750 GTPase CgtA; Reviewed; Region: obgE; PRK12297 891968002751 GTP1/OBG; Region: GTP1_OBG; pfam01018 891968002752 Obg GTPase; Region: Obg; cd01898 891968002753 G1 box; other site 891968002754 GTP/Mg2+ binding site [chemical binding]; other site 891968002755 Switch I region; other site 891968002756 G2 box; other site 891968002757 G3 box; other site 891968002758 Switch II region; other site 891968002759 G4 box; other site 891968002760 G5 box; other site 891968002761 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 891968002762 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 891968002763 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 891968002764 active site 891968002765 (T/H)XGH motif; other site 891968002766 Transcriptional regulator [Transcription]; Region: LytR; COG1316 891968002767 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 891968002768 Oligomerisation domain; Region: Oligomerisation; pfam02410 891968002769 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 891968002770 triosephosphate isomerase; Provisional; Region: PRK14565 891968002771 substrate binding site [chemical binding]; other site 891968002772 dimer interface [polypeptide binding]; other site 891968002773 catalytic triad [active] 891968002774 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 891968002775 Phosphoglycerate kinase; Region: PGK; pfam00162 891968002776 substrate binding site [chemical binding]; other site 891968002777 hinge regions; other site 891968002778 ADP binding site [chemical binding]; other site 891968002779 catalytic site [active] 891968002780 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 891968002781 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 891968002782 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 891968002783 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 891968002784 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 891968002785 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 891968002786 phosphate binding site [ion binding]; other site 891968002787 putative substrate binding pocket [chemical binding]; other site 891968002788 dimer interface [polypeptide binding]; other site 891968002789 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 891968002790 shikimate kinase; Reviewed; Region: aroK; PRK00131 891968002791 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 891968002792 MPT binding site; other site 891968002793 trimer interface [polypeptide binding]; other site 891968002794 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 891968002795 trimer interface [polypeptide binding]; other site 891968002796 dimer interface [polypeptide binding]; other site 891968002797 putative active site [active] 891968002798 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 891968002799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968002800 FeS/SAM binding site; other site 891968002801 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 891968002802 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 891968002803 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 891968002804 dimer interface [polypeptide binding]; other site 891968002805 putative functional site; other site 891968002806 putative MPT binding site; other site 891968002807 PBP superfamily domain; Region: PBP_like; pfam12727 891968002808 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 891968002809 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 891968002810 dimer interface [polypeptide binding]; other site 891968002811 putative functional site; other site 891968002812 putative MPT binding site; other site 891968002813 Sporulation related domain; Region: SPOR; pfam05036 891968002814 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 891968002815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968002816 FeS/SAM binding site; other site 891968002817 cell division protein FtsZ; Validated; Region: PRK09330 891968002818 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 891968002819 nucleotide binding site [chemical binding]; other site 891968002820 SulA interaction site; other site 891968002821 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 891968002822 Cell division protein FtsA; Region: FtsA; smart00842 891968002823 Cell division protein FtsA; Region: FtsA; pfam14450 891968002824 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 891968002825 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 891968002826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968002827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 891968002828 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968002829 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 891968002830 cell division protein FtsW; Region: ftsW; TIGR02614 891968002831 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 891968002832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968002833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 891968002834 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 891968002835 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 891968002836 Mg++ binding site [ion binding]; other site 891968002837 putative catalytic motif [active] 891968002838 putative substrate binding site [chemical binding]; other site 891968002839 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 891968002840 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 891968002841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968002842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 891968002843 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 891968002844 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 891968002845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968002846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 891968002847 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 891968002848 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 891968002849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 891968002850 MraW methylase family; Region: Methyltransf_5; cl17771 891968002851 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 891968002852 cell division protein MraZ; Reviewed; Region: PRK00326 891968002853 MraZ protein; Region: MraZ; pfam02381 891968002854 MraZ protein; Region: MraZ; pfam02381 891968002855 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 891968002856 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 891968002857 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 891968002858 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 891968002859 V-type ATP synthase subunit B; Provisional; Region: PRK04196 891968002860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968002861 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 891968002862 Walker A motif homologous position; other site 891968002863 Walker B motif; other site 891968002864 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968002865 V-type ATP synthase subunit A; Provisional; Region: PRK04192 891968002866 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968002867 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 891968002868 Walker A motif/ATP binding site; other site 891968002869 Walker B motif; other site 891968002870 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968002871 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 891968002872 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 891968002873 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 891968002874 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 891968002875 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 891968002876 V-type ATP synthase subunit K; Validated; Region: PRK06558 891968002877 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 891968002878 V-type ATP synthase subunit I; Validated; Region: PRK05771 891968002879 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 891968002880 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 891968002881 MutS domain III; Region: MutS_III; pfam05192 891968002882 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 891968002883 Walker A/P-loop; other site 891968002884 ATP binding site [chemical binding]; other site 891968002885 Q-loop/lid; other site 891968002886 ABC transporter signature motif; other site 891968002887 Walker B; other site 891968002888 D-loop; other site 891968002889 H-loop/switch region; other site 891968002890 Smr domain; Region: Smr; pfam01713 891968002891 Colicin V production protein; Region: Colicin_V; pfam02674 891968002892 Cell division protein ZapA; Region: ZapA; pfam05164 891968002893 phosphodiesterase; Provisional; Region: PRK12704 891968002894 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 891968002895 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 891968002896 putative tRNA-binding site [nucleotide binding]; other site 891968002897 B3/4 domain; Region: B3_4; pfam03483 891968002898 tRNA synthetase B5 domain; Region: B5; cl08394 891968002899 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 891968002900 dimer interface [polypeptide binding]; other site 891968002901 motif 1; other site 891968002902 motif 3; other site 891968002903 motif 2; other site 891968002904 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 891968002905 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 891968002906 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 891968002907 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 891968002908 dimer interface [polypeptide binding]; other site 891968002909 motif 1; other site 891968002910 active site 891968002911 motif 2; other site 891968002912 motif 3; other site 891968002913 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 891968002914 TrkA-N domain; Region: TrkA_N; pfam02254 891968002915 TrkA-C domain; Region: TrkA_C; pfam02080 891968002916 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 891968002917 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 891968002918 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 891968002919 23S rRNA binding site [nucleotide binding]; other site 891968002920 L21 binding site [polypeptide binding]; other site 891968002921 L13 binding site [polypeptide binding]; other site 891968002922 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 891968002923 translation initiation factor IF-3; Region: infC; TIGR00168 891968002924 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 891968002925 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 891968002926 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 891968002927 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 891968002928 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 891968002929 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 891968002930 active site 891968002931 dimer interface [polypeptide binding]; other site 891968002932 motif 1; other site 891968002933 motif 2; other site 891968002934 motif 3; other site 891968002935 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 891968002936 anticodon binding site; other site 891968002937 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 891968002938 dimethyladenosine transferase; Region: ksgA; TIGR00755 891968002939 S-adenosylmethionine binding site [chemical binding]; other site 891968002940 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 891968002941 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 891968002942 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 891968002943 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 891968002944 Ligand Binding Site [chemical binding]; other site 891968002945 TIGR00269 family protein; Region: TIGR00269 891968002946 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 891968002947 Domain of unknown function (DUF814); Region: DUF814; pfam05670 891968002948 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 891968002949 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 891968002950 active site 891968002951 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 891968002952 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 891968002953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 891968002954 active site 891968002955 HIGH motif; other site 891968002956 nucleotide binding site [chemical binding]; other site 891968002957 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 891968002958 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 891968002959 active site 891968002960 KMSKS motif; other site 891968002961 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 891968002962 tRNA binding surface [nucleotide binding]; other site 891968002963 anticodon binding site; other site 891968002964 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 891968002965 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 891968002966 DctM-like transporters; Region: DctM; pfam06808 891968002967 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 891968002968 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 891968002969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968002970 S-adenosylmethionine binding site [chemical binding]; other site 891968002971 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 891968002972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968002973 FeS/SAM binding site; other site 891968002974 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 891968002975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968002976 FeS/SAM binding site; other site 891968002977 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 891968002978 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 891968002979 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 891968002980 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 891968002981 Cl binding site [ion binding]; other site 891968002982 oligomer interface [polypeptide binding]; other site 891968002983 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 891968002984 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 891968002985 active site 891968002986 Riboflavin kinase; Region: Flavokinase; pfam01687 891968002987 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 891968002988 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 891968002989 RNA binding site [nucleotide binding]; other site 891968002990 active site 891968002991 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 891968002992 DHH family; Region: DHH; pfam01368 891968002993 DHHA1 domain; Region: DHHA1; pfam02272 891968002994 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 891968002995 Protein of unknown function (DUF503); Region: DUF503; pfam04456 891968002996 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 891968002997 translation initiation factor IF-2; Region: IF-2; TIGR00487 891968002998 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 891968002999 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 891968003000 G1 box; other site 891968003001 putative GEF interaction site [polypeptide binding]; other site 891968003002 GTP/Mg2+ binding site [chemical binding]; other site 891968003003 Switch I region; other site 891968003004 G2 box; other site 891968003005 G3 box; other site 891968003006 Switch II region; other site 891968003007 G4 box; other site 891968003008 G5 box; other site 891968003009 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 891968003010 Translation-initiation factor 2; Region: IF-2; pfam11987 891968003011 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 891968003012 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 891968003013 putative RNA binding cleft [nucleotide binding]; other site 891968003014 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 891968003015 NusA N-terminal domain; Region: NusA_N; pfam08529 891968003016 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 891968003017 RNA binding site [nucleotide binding]; other site 891968003018 homodimer interface [polypeptide binding]; other site 891968003019 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 891968003020 G-X-X-G motif; other site 891968003021 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 891968003022 G-X-X-G motif; other site 891968003023 ribosome maturation protein RimP; Reviewed; Region: PRK00092 891968003024 Sm and related proteins; Region: Sm_like; cl00259 891968003025 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 891968003026 putative oligomer interface [polypeptide binding]; other site 891968003027 putative RNA binding site [nucleotide binding]; other site 891968003028 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 891968003029 IHF dimer interface [polypeptide binding]; other site 891968003030 IHF - DNA interface [nucleotide binding]; other site 891968003031 GTP-binding protein Der; Reviewed; Region: PRK00093 891968003032 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 891968003033 G1 box; other site 891968003034 GTP/Mg2+ binding site [chemical binding]; other site 891968003035 Switch I region; other site 891968003036 G2 box; other site 891968003037 Switch II region; other site 891968003038 G3 box; other site 891968003039 G4 box; other site 891968003040 G5 box; other site 891968003041 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 891968003042 G1 box; other site 891968003043 GTP/Mg2+ binding site [chemical binding]; other site 891968003044 Switch I region; other site 891968003045 G2 box; other site 891968003046 G3 box; other site 891968003047 Switch II region; other site 891968003048 G4 box; other site 891968003049 G5 box; other site 891968003050 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 891968003051 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 891968003052 Flavoprotein; Region: Flavoprotein; pfam02441 891968003053 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 891968003054 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 891968003055 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 891968003056 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 891968003057 catalytic site [active] 891968003058 G-X2-G-X-G-K; other site 891968003059 hypothetical protein; Provisional; Region: PRK04323 891968003060 hypothetical protein; Provisional; Region: PRK11820 891968003061 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 891968003062 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 891968003063 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 891968003064 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 891968003065 HflX GTPase family; Region: HflX; cd01878 891968003066 G1 box; other site 891968003067 GTP/Mg2+ binding site [chemical binding]; other site 891968003068 Switch I region; other site 891968003069 G2 box; other site 891968003070 G3 box; other site 891968003071 Switch II region; other site 891968003072 G4 box; other site 891968003073 G5 box; other site 891968003074 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 891968003075 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 891968003076 putative acyl-acceptor binding pocket; other site 891968003077 cytidylate kinase; Provisional; Region: cmk; PRK00023 891968003078 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 891968003079 CMP-binding site; other site 891968003080 The sites determining sugar specificity; other site 891968003081 HDOD domain; Region: HDOD; pfam08668 891968003082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968003083 Zn2+ binding site [ion binding]; other site 891968003084 Mg2+ binding site [ion binding]; other site 891968003085 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 891968003086 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 891968003087 RNA binding surface [nucleotide binding]; other site 891968003088 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 891968003089 active site 891968003090 uracil binding [chemical binding]; other site 891968003091 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 891968003092 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 891968003093 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 891968003094 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 891968003095 active site 891968003096 HIGH motif; other site 891968003097 dimer interface [polypeptide binding]; other site 891968003098 KMSKS motif; other site 891968003099 Uncharacterized conserved protein [Function unknown]; Region: COG0327 891968003100 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 891968003101 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 891968003102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 891968003103 pur operon repressor; Provisional; Region: PRK09213 891968003104 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 891968003105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968003106 active site 891968003107 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 891968003108 transcriptional antiterminator BglG; Provisional; Region: PRK09772 891968003109 CAT RNA binding domain; Region: CAT_RBD; smart01061 891968003110 PRD domain; Region: PRD; pfam00874 891968003111 PRD domain; Region: PRD; pfam00874 891968003112 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 891968003113 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 891968003114 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 891968003115 active site turn [active] 891968003116 phosphorylation site [posttranslational modification] 891968003117 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 891968003118 HPr interaction site; other site 891968003119 glycerol kinase (GK) interaction site [polypeptide binding]; other site 891968003120 active site 891968003121 phosphorylation site [posttranslational modification] 891968003122 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 891968003123 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 891968003124 substrate binding site [chemical binding]; other site 891968003125 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 891968003126 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 891968003127 Walker A/P-loop; other site 891968003128 ATP binding site [chemical binding]; other site 891968003129 Q-loop/lid; other site 891968003130 ABC transporter signature motif; other site 891968003131 Walker B; other site 891968003132 D-loop; other site 891968003133 H-loop/switch region; other site 891968003134 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 891968003135 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 891968003136 TM-ABC transporter signature motif; other site 891968003137 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 891968003138 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 891968003139 Walker A/P-loop; other site 891968003140 ATP binding site [chemical binding]; other site 891968003141 Q-loop/lid; other site 891968003142 ABC transporter signature motif; other site 891968003143 Walker B; other site 891968003144 D-loop; other site 891968003145 H-loop/switch region; other site 891968003146 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968003147 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 891968003148 TM-ABC transporter signature motif; other site 891968003149 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 891968003150 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 891968003151 dimerization interface [polypeptide binding]; other site 891968003152 ligand binding site [chemical binding]; other site 891968003153 aspartate kinase; Reviewed; Region: PRK06635 891968003154 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 891968003155 putative nucleotide binding site [chemical binding]; other site 891968003156 putative catalytic residues [active] 891968003157 putative Mg ion binding site [ion binding]; other site 891968003158 putative aspartate binding site [chemical binding]; other site 891968003159 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 891968003160 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 891968003161 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 891968003162 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 891968003163 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 891968003164 trimer interface [polypeptide binding]; other site 891968003165 active site 891968003166 substrate binding site [chemical binding]; other site 891968003167 CoA binding site [chemical binding]; other site 891968003168 dihydrodipicolinate reductase; Provisional; Region: PRK00048 891968003169 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 891968003170 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 891968003171 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 891968003172 dihydrodipicolinate synthase; Region: dapA; TIGR00674 891968003173 dimer interface [polypeptide binding]; other site 891968003174 active site 891968003175 catalytic residue [active] 891968003176 Cupin domain; Region: Cupin_2; pfam07883 891968003177 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 891968003178 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 891968003179 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968003180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968003181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968003182 PIF1-like helicase; Region: PIF1; pfam05970 891968003183 AAA domain; Region: AAA_30; pfam13604 891968003184 Helicase; Region: Herpes_Helicase; pfam02689 891968003185 WYL domain; Region: WYL; pfam13280 891968003186 Bifunctional nuclease; Region: DNase-RNase; pfam02577 891968003187 acetyl-lysine deacetylase; Provisional; Region: PRK04443 891968003188 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 891968003189 metal binding site [ion binding]; metal-binding site 891968003190 putative dimer interface [polypeptide binding]; other site 891968003191 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 891968003192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 891968003193 inhibitor-cofactor binding pocket; inhibition site 891968003194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968003195 catalytic residue [active] 891968003196 acetylglutamate/acetylaminoadipate kinase; Provisional; Region: PRK14058 891968003197 nucleotide binding site [chemical binding]; other site 891968003198 substrate binding site [chemical binding]; other site 891968003199 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 891968003200 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 891968003201 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 891968003202 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003203 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 891968003204 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 891968003205 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 891968003206 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968003207 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968003208 metal binding site [ion binding]; metal-binding site 891968003209 dimer interface [polypeptide binding]; other site 891968003210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968003211 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 891968003212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 891968003213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003214 dimer interface [polypeptide binding]; other site 891968003215 conserved gate region; other site 891968003216 putative PBP binding loops; other site 891968003217 ABC-ATPase subunit interface; other site 891968003218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 891968003219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003220 dimer interface [polypeptide binding]; other site 891968003221 conserved gate region; other site 891968003222 ABC-ATPase subunit interface; other site 891968003223 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 891968003224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968003225 Walker A/P-loop; other site 891968003226 ATP binding site [chemical binding]; other site 891968003227 Q-loop/lid; other site 891968003228 ABC transporter signature motif; other site 891968003229 Walker B; other site 891968003230 D-loop; other site 891968003231 H-loop/switch region; other site 891968003232 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968003233 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 891968003234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968003235 Walker A/P-loop; other site 891968003236 ATP binding site [chemical binding]; other site 891968003237 Q-loop/lid; other site 891968003238 ABC transporter signature motif; other site 891968003239 Walker B; other site 891968003240 D-loop; other site 891968003241 H-loop/switch region; other site 891968003242 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968003243 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 891968003244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 891968003245 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 891968003246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003247 dimer interface [polypeptide binding]; other site 891968003248 conserved gate region; other site 891968003249 putative PBP binding loops; other site 891968003250 ABC-ATPase subunit interface; other site 891968003251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003252 dimer interface [polypeptide binding]; other site 891968003253 conserved gate region; other site 891968003254 putative PBP binding loops; other site 891968003255 ABC-ATPase subunit interface; other site 891968003256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968003257 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 891968003258 Walker A/P-loop; other site 891968003259 ATP binding site [chemical binding]; other site 891968003260 Q-loop/lid; other site 891968003261 ABC transporter signature motif; other site 891968003262 Walker B; other site 891968003263 D-loop; other site 891968003264 H-loop/switch region; other site 891968003265 TOBE domain; Region: TOBE_2; pfam08402 891968003266 MOSC domain; Region: MOSC; pfam03473 891968003267 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 891968003268 Amino acid permease; Region: AA_permease_2; pfam13520 891968003269 Uncharacterized conserved protein [Function unknown]; Region: COG2014 891968003270 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 891968003271 Domain of unknown function (DUF364); Region: DUF364; pfam04016 891968003272 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 891968003273 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 891968003274 G1 box; other site 891968003275 putative GEF interaction site [polypeptide binding]; other site 891968003276 GTP/Mg2+ binding site [chemical binding]; other site 891968003277 Switch I region; other site 891968003278 G2 box; other site 891968003279 G3 box; other site 891968003280 Switch II region; other site 891968003281 G4 box; other site 891968003282 G5 box; other site 891968003283 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 891968003284 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 891968003285 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 891968003286 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 891968003287 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 891968003288 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 891968003289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968003290 catalytic residue [active] 891968003291 allantoate amidohydrolase; Reviewed; Region: PRK09290 891968003292 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 891968003293 active site 891968003294 metal binding site [ion binding]; metal-binding site 891968003295 dimer interface [polypeptide binding]; other site 891968003296 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968003297 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 891968003298 metal binding site [ion binding]; metal-binding site 891968003299 putative dimer interface [polypeptide binding]; other site 891968003300 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 891968003301 Isochorismatase family; Region: Isochorismatase; pfam00857 891968003302 catalytic triad [active] 891968003303 metal binding site [ion binding]; metal-binding site 891968003304 conserved cis-peptide bond; other site 891968003305 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 891968003306 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 891968003307 CPxP motif; other site 891968003308 DsrE/DsrF-like family; Region: DrsE; cl00672 891968003309 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 891968003310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968003311 FeS/SAM binding site; other site 891968003312 GTP-binding protein LepA; Provisional; Region: PRK05433 891968003313 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 891968003314 G1 box; other site 891968003315 putative GEF interaction site [polypeptide binding]; other site 891968003316 GTP/Mg2+ binding site [chemical binding]; other site 891968003317 Switch I region; other site 891968003318 G2 box; other site 891968003319 G3 box; other site 891968003320 Switch II region; other site 891968003321 G4 box; other site 891968003322 G5 box; other site 891968003323 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 891968003324 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 891968003325 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 891968003326 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 891968003327 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 891968003328 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 891968003329 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 891968003330 generic binding surface I; other site 891968003331 generic binding surface II; other site 891968003332 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 891968003333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968003334 Zn2+ binding site [ion binding]; other site 891968003335 Mg2+ binding site [ion binding]; other site 891968003336 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 891968003337 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 891968003338 active site 891968003339 dimer interface [polypeptide binding]; other site 891968003340 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 891968003341 FMN binding site [chemical binding]; other site 891968003342 dimer interface [polypeptide binding]; other site 891968003343 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 891968003344 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 891968003345 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 891968003346 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 891968003347 Ligand binding site; other site 891968003348 DXD motif; other site 891968003349 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 891968003350 putative catalytic site [active] 891968003351 putative metal binding site [ion binding]; other site 891968003352 putative phosphate binding site [ion binding]; other site 891968003353 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 891968003354 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 891968003355 putative active site [active] 891968003356 catalytic site [active] 891968003357 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 891968003358 putative active site [active] 891968003359 catalytic site [active] 891968003360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968003362 putative substrate translocation pore; other site 891968003363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968003365 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968003366 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 891968003367 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 891968003368 homodimer interface [polypeptide binding]; other site 891968003369 homotetramer interface [polypeptide binding]; other site 891968003370 active site pocket [active] 891968003371 cleavage site 891968003372 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 891968003373 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 891968003374 active site 891968003375 putative substrate binding pocket [chemical binding]; other site 891968003376 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 891968003377 Transcriptional regulator [Transcription]; Region: IclR; COG1414 891968003378 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 891968003379 Bacterial transcriptional regulator; Region: IclR; pfam01614 891968003380 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 891968003381 EamA-like transporter family; Region: EamA; pfam00892 891968003382 Cation transport protein; Region: TrkH; cl17365 891968003383 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 891968003384 TrkA-N domain; Region: TrkA_N; pfam02254 891968003385 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 891968003386 TrkA-C domain; Region: TrkA_C; pfam02080 891968003387 TrkA-N domain; Region: TrkA_N; pfam02254 891968003388 TrkA-C domain; Region: TrkA_C; pfam02080 891968003389 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 891968003390 active site 891968003391 homotetramer interface [polypeptide binding]; other site 891968003392 homodimer interface [polypeptide binding]; other site 891968003393 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 891968003394 Carbon starvation protein CstA; Region: CstA; pfam02554 891968003395 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 891968003396 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 891968003397 P loop; other site 891968003398 Nucleotide binding site [chemical binding]; other site 891968003399 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 891968003400 DTAP/Switch II; other site 891968003401 Switch I; other site 891968003402 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 891968003403 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 891968003404 glutaminase active site [active] 891968003405 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 891968003406 dimer interface [polypeptide binding]; other site 891968003407 active site 891968003408 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 891968003409 dimer interface [polypeptide binding]; other site 891968003410 active site 891968003411 BCCT family transporter; Region: BCCT; pfam02028 891968003412 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 891968003413 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 891968003414 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 891968003415 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 891968003416 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 891968003417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 891968003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968003419 active site 891968003420 phosphorylation site [posttranslational modification] 891968003421 intermolecular recognition site; other site 891968003422 dimerization interface [polypeptide binding]; other site 891968003423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 891968003424 DNA binding residues [nucleotide binding] 891968003425 dimerization interface [polypeptide binding]; other site 891968003426 PAS domain; Region: PAS_9; pfam13426 891968003427 PAS domain; Region: PAS; smart00091 891968003428 putative active site [active] 891968003429 heme pocket [chemical binding]; other site 891968003430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 891968003431 Histidine kinase; Region: HisKA_3; pfam07730 891968003432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968003433 ATP binding site [chemical binding]; other site 891968003434 Mg2+ binding site [ion binding]; other site 891968003435 G-X-G motif; other site 891968003436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 891968003437 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 891968003438 acyl-activating enzyme (AAE) consensus motif; other site 891968003439 active site 891968003440 AMP binding site [chemical binding]; other site 891968003441 CoA binding site [chemical binding]; other site 891968003442 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 891968003443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968003444 FeS/SAM binding site; other site 891968003445 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 891968003446 Methyltransferase domain; Region: Methyltransf_23; pfam13489 891968003447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968003448 S-adenosylmethionine binding site [chemical binding]; other site 891968003449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 891968003450 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 891968003451 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 891968003452 Cysteine-rich domain; Region: CCG; pfam02754 891968003453 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968003454 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 891968003455 catalytic loop [active] 891968003456 iron binding site [ion binding]; other site 891968003457 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968003458 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968003459 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968003460 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 891968003461 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968003462 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968003463 metal binding site [ion binding]; metal-binding site 891968003464 dimer interface [polypeptide binding]; other site 891968003465 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 891968003466 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 891968003467 dimer interface [polypeptide binding]; other site 891968003468 active site 891968003469 glycine-pyridoxal phosphate binding site [chemical binding]; other site 891968003470 folate binding site [chemical binding]; other site 891968003471 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 891968003472 dimer interface [polypeptide binding]; other site 891968003473 catalytic triad [active] 891968003474 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 891968003475 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 891968003476 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 891968003477 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 891968003478 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 891968003479 putative dimer interface [polypeptide binding]; other site 891968003480 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 891968003481 putative deacylase active site [active] 891968003482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 891968003483 binding surface 891968003484 TPR motif; other site 891968003485 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 891968003486 N-acetyl-D-glucosamine binding site [chemical binding]; other site 891968003487 catalytic residue [active] 891968003488 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 891968003489 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 891968003490 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 891968003491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 891968003492 non-specific DNA binding site [nucleotide binding]; other site 891968003493 salt bridge; other site 891968003494 sequence-specific DNA binding site [nucleotide binding]; other site 891968003495 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 891968003496 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 891968003497 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 891968003498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 891968003499 active site 891968003500 catalytic tetrad [active] 891968003501 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 891968003502 Tetratricopeptide repeat; Region: TPR_12; pfam13424 891968003503 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 891968003504 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 891968003505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 891968003506 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003507 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 891968003508 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 891968003509 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003510 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 891968003511 substrate binding site [chemical binding]; other site 891968003512 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 891968003513 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968003514 putative active site [active] 891968003515 putative metal binding site [ion binding]; other site 891968003516 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 891968003517 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 891968003518 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 891968003519 transmembrane helices; other site 891968003520 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 891968003521 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 891968003522 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 891968003523 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 891968003524 Uncharacterized conserved protein [Function unknown]; Region: COG2006 891968003525 Domain of unknown function (DUF362); Region: DUF362; pfam04015 891968003526 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 891968003527 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 891968003528 phage exclusion protein Lit; Provisional; Region: PRK09672 891968003529 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 891968003530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968003531 Walker A/P-loop; other site 891968003532 ATP binding site [chemical binding]; other site 891968003533 Q-loop/lid; other site 891968003534 ABC transporter signature motif; other site 891968003535 Walker B; other site 891968003536 D-loop; other site 891968003537 H-loop/switch region; other site 891968003538 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 891968003539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003540 dimer interface [polypeptide binding]; other site 891968003541 conserved gate region; other site 891968003542 putative PBP binding loops; other site 891968003543 ABC-ATPase subunit interface; other site 891968003544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 891968003545 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 891968003546 Sulfatase; Region: Sulfatase; cl17466 891968003547 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 891968003548 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 891968003549 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 891968003550 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 891968003551 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 891968003552 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 891968003553 oligomer interface [polypeptide binding]; other site 891968003554 active site 891968003555 metal binding site [ion binding]; metal-binding site 891968003556 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 891968003557 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 891968003558 oligomer interface [polypeptide binding]; other site 891968003559 active site 891968003560 metal binding site [ion binding]; metal-binding site 891968003561 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 891968003562 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 891968003563 oligomer interface [polypeptide binding]; other site 891968003564 active site 891968003565 metal binding site [ion binding]; metal-binding site 891968003566 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 891968003567 putative active site [active] 891968003568 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 891968003569 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 891968003570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 891968003571 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 891968003572 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 891968003573 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 891968003574 isoaspartyl dipeptidase; Provisional; Region: PRK10657 891968003575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968003576 active site 891968003577 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968003578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968003579 DNA-binding site [nucleotide binding]; DNA binding site 891968003580 FCD domain; Region: FCD; pfam07729 891968003581 Cupin domain; Region: Cupin_2; pfam07883 891968003582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 891968003583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968003584 DNA-binding site [nucleotide binding]; DNA binding site 891968003585 FCD domain; Region: FCD; pfam07729 891968003586 DctM-like transporters; Region: DctM; pfam06808 891968003587 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968003588 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 891968003589 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968003590 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968003591 mannonate dehydratase; Provisional; Region: PRK03906 891968003592 mannonate dehydratase; Region: uxuA; TIGR00695 891968003593 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 891968003594 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 891968003595 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 891968003596 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 891968003597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968003598 FeS/SAM binding site; other site 891968003599 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 891968003600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968003601 FeS/SAM binding site; other site 891968003602 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 891968003603 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 891968003604 Cache domain; Region: Cache_1; pfam02743 891968003605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 891968003606 dimerization interface [polypeptide binding]; other site 891968003607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 891968003608 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 891968003609 dimer interface [polypeptide binding]; other site 891968003610 putative CheW interface [polypeptide binding]; other site 891968003611 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 891968003612 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 891968003613 putative active site [active] 891968003614 metal binding site [ion binding]; metal-binding site 891968003615 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 891968003616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003617 putative substrate translocation pore; other site 891968003618 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 891968003619 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 891968003620 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 891968003621 putative NADH binding site [chemical binding]; other site 891968003622 putative active site [active] 891968003623 nudix motif; other site 891968003624 putative metal binding site [ion binding]; other site 891968003625 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 891968003626 putative ADP-ribose binding site [chemical binding]; other site 891968003627 putative active site [active] 891968003628 Transposase, Mutator family; Region: Transposase_mut; pfam00872 891968003629 MULE transposase domain; Region: MULE; pfam10551 891968003630 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 891968003631 CPxP motif; other site 891968003632 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 891968003633 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 891968003634 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 891968003635 active site 891968003636 trimer interface [polypeptide binding]; other site 891968003637 allosteric site; other site 891968003638 active site lid [active] 891968003639 hexamer (dimer of trimers) interface [polypeptide binding]; other site 891968003640 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 891968003641 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 891968003642 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 891968003643 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 891968003644 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 891968003645 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 891968003646 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 891968003647 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 891968003648 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 891968003649 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661 891968003650 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 891968003651 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 891968003652 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 891968003653 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003654 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 891968003655 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 891968003656 trimer interface I [polypeptide binding]; other site 891968003657 putative substrate binding pocket [chemical binding]; other site 891968003658 trimer interface II [polypeptide binding]; other site 891968003659 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 891968003660 domain_subunit interface; other site 891968003661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 891968003662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 891968003663 dimer interface [polypeptide binding]; other site 891968003664 putative CheW interface [polypeptide binding]; other site 891968003665 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 891968003666 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 891968003667 FTR, proximal lobe; Region: FTR_C; pfam02741 891968003668 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 891968003669 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 891968003670 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 891968003671 Protein of unknown function (DUF447); Region: DUF447; pfam04289 891968003672 dihydropteroate synthase-related protein; Region: TIGR00284 891968003673 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 891968003674 substrate binding pocket [chemical binding]; other site 891968003675 dimer interface [polypeptide binding]; other site 891968003676 inhibitor binding site; inhibition site 891968003677 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 891968003678 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 891968003679 catalytic center binding site [active] 891968003680 ATP binding site [chemical binding]; other site 891968003681 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 891968003682 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 891968003683 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968003684 active site 891968003685 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 891968003686 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 891968003687 putative [4Fe-4S] binding site [ion binding]; other site 891968003688 putative molybdopterin cofactor binding site [chemical binding]; other site 891968003689 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 891968003690 molybdopterin cofactor binding site; other site 891968003691 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 891968003692 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003693 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 891968003694 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 891968003695 NADP binding site [chemical binding]; other site 891968003696 Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034 891968003697 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 891968003698 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 891968003699 GTP binding site; other site 891968003700 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 891968003701 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 891968003702 Protein of unknown function DUF86; Region: DUF86; pfam01934 891968003703 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 891968003704 active site 891968003705 NTP binding site [chemical binding]; other site 891968003706 metal binding triad [ion binding]; metal-binding site 891968003707 Autotransporter beta-domain; Region: Autotransporter; smart00869 891968003708 DctM-like transporters; Region: DctM; pfam06808 891968003709 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968003710 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 891968003711 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968003712 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968003713 AAA domain; Region: AAA_14; pfam13173 891968003714 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 891968003715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 891968003716 dimerization interface [polypeptide binding]; other site 891968003717 putative DNA binding site [nucleotide binding]; other site 891968003718 putative Zn2+ binding site [ion binding]; other site 891968003719 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 891968003720 B3/4 domain; Region: B3_4; pfam03483 891968003721 RelB antitoxin; Region: RelB; cl01171 891968003722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 891968003723 YcfA-like protein; Region: YcfA; pfam07927 891968003724 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 891968003725 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 891968003726 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 891968003727 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 891968003728 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 891968003729 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 891968003730 Ligand binding site [chemical binding]; other site 891968003731 Electron transfer flavoprotein domain; Region: ETF; pfam01012 891968003732 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 891968003733 FAD binding domain; Region: FAD_binding_4; pfam01565 891968003734 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 891968003735 YcfA-like protein; Region: YcfA; pfam07927 891968003736 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 891968003737 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 891968003738 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 891968003739 PemK-like protein; Region: PemK; cl00995 891968003740 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 891968003741 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 891968003742 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 891968003743 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 891968003744 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 891968003745 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 891968003746 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 891968003747 putative NAD(P) binding site [chemical binding]; other site 891968003748 active site 891968003749 putative substrate binding site [chemical binding]; other site 891968003750 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 891968003751 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968003752 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 891968003753 active site 891968003754 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 891968003755 homodimer interface [polypeptide binding]; other site 891968003756 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 891968003757 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 891968003758 putative ADP-binding pocket [chemical binding]; other site 891968003759 Transposase [DNA replication, recombination, and repair]; Region: COG5421 891968003760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968003761 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968003762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968003763 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 891968003764 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 891968003765 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 891968003766 putative ADP-binding pocket [chemical binding]; other site 891968003767 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 891968003768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968003769 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968003770 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 891968003771 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 891968003772 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 891968003773 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 891968003774 inhibitor-cofactor binding pocket; inhibition site 891968003775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968003776 catalytic residue [active] 891968003777 putative trimer interface [polypeptide binding]; other site 891968003778 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 891968003779 putative CoA binding site [chemical binding]; other site 891968003780 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 891968003781 putative trimer interface [polypeptide binding]; other site 891968003782 putative active site [active] 891968003783 putative substrate binding site [chemical binding]; other site 891968003784 putative CoA binding site [chemical binding]; other site 891968003785 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 891968003786 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 891968003787 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 891968003788 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 891968003789 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 891968003790 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 891968003791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 891968003792 dimerization interface [polypeptide binding]; other site 891968003793 putative DNA binding site [nucleotide binding]; other site 891968003794 putative Zn2+ binding site [ion binding]; other site 891968003795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 891968003796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 891968003797 non-specific DNA binding site [nucleotide binding]; other site 891968003798 salt bridge; other site 891968003799 sequence-specific DNA binding site [nucleotide binding]; other site 891968003800 Helix-turn-helix domain; Region: HTH_36; pfam13730 891968003801 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 891968003802 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 891968003803 YvrJ protein family; Region: YvrJ; pfam12841 891968003804 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 891968003805 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 891968003806 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 891968003807 active site 891968003808 NTP binding site [chemical binding]; other site 891968003809 metal binding triad [ion binding]; metal-binding site 891968003810 antibiotic binding site [chemical binding]; other site 891968003811 Uncharacterized conserved protein [Function unknown]; Region: COG2445 891968003812 Archaeal ATPase; Region: Arch_ATPase; pfam01637 891968003813 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 891968003814 Bacterial sugar transferase; Region: Bac_transf; pfam02397 891968003815 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 891968003816 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 891968003817 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 891968003818 SLBB domain; Region: SLBB; pfam10531 891968003819 SLBB domain; Region: SLBB; pfam10531 891968003820 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 891968003821 Chain length determinant protein; Region: Wzz; pfam02706 891968003822 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 891968003823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968003824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968003825 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 891968003826 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 891968003827 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 891968003828 Bacterial sugar transferase; Region: Bac_transf; pfam02397 891968003829 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 891968003830 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 891968003831 Probable Catalytic site; other site 891968003832 metal-binding site 891968003833 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 891968003834 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 891968003835 active site 891968003836 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 891968003837 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 891968003838 Probable Catalytic site; other site 891968003839 metal-binding site 891968003840 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 891968003841 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 891968003842 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 891968003843 substrate binding site; other site 891968003844 tetramer interface; other site 891968003845 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 891968003846 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 891968003847 NAD binding site [chemical binding]; other site 891968003848 substrate binding site [chemical binding]; other site 891968003849 homodimer interface [polypeptide binding]; other site 891968003850 active site 891968003851 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 891968003852 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 891968003853 NADP binding site [chemical binding]; other site 891968003854 active site 891968003855 putative substrate binding site [chemical binding]; other site 891968003856 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 891968003857 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 891968003858 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 891968003859 O-Antigen ligase; Region: Wzy_C; pfam04932 891968003860 Methyltransferase domain; Region: Methyltransf_31; pfam13847 891968003861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968003862 S-adenosylmethionine binding site [chemical binding]; other site 891968003863 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 891968003864 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 891968003865 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 891968003866 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 891968003867 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 891968003868 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 891968003869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 891968003870 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 891968003871 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 891968003872 ZIP Zinc transporter; Region: Zip; pfam02535 891968003873 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 891968003874 Predicted amidohydrolase [General function prediction only]; Region: COG0388 891968003875 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 891968003876 active site 891968003877 catalytic triad [active] 891968003878 dimer interface [polypeptide binding]; other site 891968003879 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 891968003880 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 891968003881 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 891968003882 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 891968003883 metal binding site [ion binding]; metal-binding site 891968003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968003886 putative substrate translocation pore; other site 891968003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 891968003889 endonuclease III; Region: ENDO3c; smart00478 891968003890 minor groove reading motif; other site 891968003891 helix-hairpin-helix signature motif; other site 891968003892 substrate binding pocket [chemical binding]; other site 891968003893 active site 891968003894 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 891968003895 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 891968003896 active site 891968003897 ADP/pyrophosphate binding site [chemical binding]; other site 891968003898 dimerization interface [polypeptide binding]; other site 891968003899 allosteric effector site; other site 891968003900 fructose-1,6-bisphosphate binding site; other site 891968003901 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 891968003902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968003903 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 891968003904 AAK_UC: Uncharacterized (UC) amino acid kinase-like proteins found mainly in archaea and a few bacteria. Sequences in this CD are members of the Amino Acid Kinase (AAK) superfamily; Region: AAK_UC; cd04240 891968003905 putative nucleotide binding site [chemical binding]; other site 891968003906 putative substrate binding site [chemical binding]; other site 891968003907 hypothetical protein; Provisional; Region: PRK02227 891968003908 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 891968003909 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 891968003910 active site 891968003911 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 891968003912 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 891968003913 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 891968003914 E3 interaction surface; other site 891968003915 lipoyl attachment site [posttranslational modification]; other site 891968003916 e3 binding domain; Region: E3_binding; pfam02817 891968003917 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 891968003918 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 891968003919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 891968003920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 891968003921 NAD(P) binding site [chemical binding]; other site 891968003922 active site 891968003923 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 891968003924 dimer interface [polypeptide binding]; other site 891968003925 metal binding site [ion binding]; metal-binding site 891968003926 substrate binding site [chemical binding]; other site 891968003927 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 891968003928 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 891968003929 alpha subunit interface [polypeptide binding]; other site 891968003930 TPP binding site [chemical binding]; other site 891968003931 heterodimer interface [polypeptide binding]; other site 891968003932 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968003933 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 891968003934 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 891968003935 tetramer interface [polypeptide binding]; other site 891968003936 TPP-binding site [chemical binding]; other site 891968003937 heterodimer interface [polypeptide binding]; other site 891968003938 phosphorylation loop region [posttranslational modification] 891968003939 lipoyl synthase; Provisional; Region: PRK05481 891968003940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968003941 FeS/SAM binding site; other site 891968003942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 891968003943 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 891968003944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968003945 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 891968003946 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 891968003947 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 891968003948 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 891968003949 MgtE intracellular N domain; Region: MgtE_N; smart00924 891968003950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 891968003951 Divalent cation transporter; Region: MgtE; pfam01769 891968003952 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 891968003953 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 891968003954 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 891968003955 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 891968003956 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 891968003957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 891968003958 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 891968003959 substrate binding pocket [chemical binding]; other site 891968003960 membrane-bound complex binding site; other site 891968003961 hinge residues; other site 891968003962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003963 dimer interface [polypeptide binding]; other site 891968003964 conserved gate region; other site 891968003965 putative PBP binding loops; other site 891968003966 ABC-ATPase subunit interface; other site 891968003967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 891968003968 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 891968003969 Walker A/P-loop; other site 891968003970 ATP binding site [chemical binding]; other site 891968003971 Q-loop/lid; other site 891968003972 ABC transporter signature motif; other site 891968003973 Walker B; other site 891968003974 D-loop; other site 891968003975 H-loop/switch region; other site 891968003976 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 891968003977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968003978 dimer interface [polypeptide binding]; other site 891968003979 conserved gate region; other site 891968003980 putative PBP binding loops; other site 891968003981 ABC-ATPase subunit interface; other site 891968003982 Transcriptional regulator [Transcription]; Region: IclR; COG1414 891968003983 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 891968003984 Bacterial transcriptional regulator; Region: IclR; pfam01614 891968003985 urocanate hydratase; Provisional; Region: PRK05414 891968003986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 891968003987 Nucleoside recognition; Region: Gate; pfam07670 891968003988 Predicted membrane protein [Function unknown]; Region: COG1288 891968003989 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 891968003990 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 891968003991 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 891968003992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 891968003993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968003994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968003995 putative substrate translocation pore; other site 891968003996 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968003997 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968003998 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968003999 DctM-like transporters; Region: DctM; pfam06808 891968004000 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 891968004001 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 891968004002 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 891968004003 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 891968004004 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 891968004005 shikimate binding site; other site 891968004006 NAD(P) binding site [chemical binding]; other site 891968004007 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 891968004008 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 891968004009 putative catalytic cysteine [active] 891968004010 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 891968004011 active site 891968004012 catalytic residues [active] 891968004013 metal binding site [ion binding]; metal-binding site 891968004014 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 891968004015 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 891968004016 PYR/PP interface [polypeptide binding]; other site 891968004017 dimer interface [polypeptide binding]; other site 891968004018 TPP binding site [chemical binding]; other site 891968004019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 891968004020 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 891968004021 TPP-binding site [chemical binding]; other site 891968004022 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 891968004023 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 891968004024 active site 891968004025 catalytic residue [active] 891968004026 dimer interface [polypeptide binding]; other site 891968004027 Transcriptional regulator [Transcription]; Region: IclR; COG1414 891968004028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 891968004029 putative DNA binding site [nucleotide binding]; other site 891968004030 putative Zn2+ binding site [ion binding]; other site 891968004031 Bacterial transcriptional regulator; Region: IclR; pfam01614 891968004032 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 891968004033 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 891968004034 tetramer interface [polypeptide binding]; other site 891968004035 active site 891968004036 Mg2+/Mn2+ binding site [ion binding]; other site 891968004037 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 891968004038 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 891968004039 active site 891968004040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 891968004041 putative DNA binding site [nucleotide binding]; other site 891968004042 Repressor of nif and glnA expression [Transcription]; Region: COG1693 891968004043 putative Zn2+ binding site [ion binding]; other site 891968004044 Domain of unknown function DUF128; Region: DUF128; pfam01995 891968004045 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 891968004046 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 891968004047 tetramer interface [polypeptide binding]; other site 891968004048 active site 891968004049 Mg2+/Mn2+ binding site [ion binding]; other site 891968004050 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 891968004051 DctM-like transporters; Region: DctM; pfam06808 891968004052 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 891968004053 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 891968004054 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 891968004055 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 891968004056 substrate binding site [chemical binding]; other site 891968004057 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 891968004058 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 891968004059 substrate binding site [chemical binding]; other site 891968004060 ligand binding site [chemical binding]; other site 891968004061 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 891968004062 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 891968004063 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 891968004064 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 891968004065 2-methylcitrate dehydratase; Region: prpD; TIGR02330 891968004066 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 891968004067 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 891968004068 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 891968004069 active site 891968004070 NTP binding site [chemical binding]; other site 891968004071 metal binding triad [ion binding]; metal-binding site 891968004072 antibiotic binding site [chemical binding]; other site 891968004073 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 891968004074 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 891968004075 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 891968004076 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 891968004077 MOFRL family; Region: MOFRL; pfam05161 891968004078 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 891968004079 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 891968004080 active site 891968004081 NAD binding site [chemical binding]; other site 891968004082 metal binding site [ion binding]; metal-binding site 891968004083 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 891968004084 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 891968004085 oligomer interface [polypeptide binding]; other site 891968004086 active site 891968004087 metal binding site [ion binding]; metal-binding site 891968004088 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968004089 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968004090 metal binding site [ion binding]; metal-binding site 891968004091 dimer interface [polypeptide binding]; other site 891968004092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 891968004093 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469 891968004094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968004095 FeS/SAM binding site; other site 891968004096 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 891968004097 active site 891968004098 metal-binding site [ion binding] 891968004099 nucleotide-binding site [chemical binding]; other site 891968004100 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 891968004101 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 891968004102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 891968004103 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 891968004104 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 891968004105 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 891968004106 transaminase; Validated; Region: PRK07324 891968004107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968004108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968004109 homodimer interface [polypeptide binding]; other site 891968004110 catalytic residue [active] 891968004111 aspartate aminotransferase; Provisional; Region: PRK05764 891968004112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968004113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968004114 homodimer interface [polypeptide binding]; other site 891968004115 catalytic residue [active] 891968004116 Dehydratase family; Region: ILVD_EDD; pfam00920 891968004117 GntP family permease; Region: GntP_permease; pfam02447 891968004118 fructuronate transporter; Provisional; Region: PRK10034; cl15264 891968004119 Transcriptional regulator [Transcription]; Region: IclR; COG1414 891968004120 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 891968004121 Bacterial transcriptional regulator; Region: IclR; pfam01614 891968004122 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 891968004123 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 891968004124 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 891968004125 ATP binding site [chemical binding]; other site 891968004126 active site 891968004127 substrate binding site [chemical binding]; other site 891968004128 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 891968004129 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 891968004130 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 891968004131 putative active site [active] 891968004132 catalytic triad [active] 891968004133 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 891968004134 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 891968004135 dimerization interface [polypeptide binding]; other site 891968004136 ATP binding site [chemical binding]; other site 891968004137 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 891968004138 dimerization interface [polypeptide binding]; other site 891968004139 ATP binding site [chemical binding]; other site 891968004140 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 891968004141 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 891968004142 active site 891968004143 tetramer interface [polypeptide binding]; other site 891968004144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968004145 active site 891968004146 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 891968004147 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 891968004148 dimerization interface [polypeptide binding]; other site 891968004149 putative ATP binding site [chemical binding]; other site 891968004150 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 891968004151 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 891968004152 active site 891968004153 substrate binding site [chemical binding]; other site 891968004154 cosubstrate binding site; other site 891968004155 catalytic site [active] 891968004156 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 891968004157 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 891968004158 purine monophosphate binding site [chemical binding]; other site 891968004159 dimer interface [polypeptide binding]; other site 891968004160 putative catalytic residues [active] 891968004161 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 891968004162 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 891968004163 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 891968004164 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 891968004165 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 891968004166 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 891968004167 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 891968004168 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 891968004169 nucleoside/Zn binding site; other site 891968004170 dimer interface [polypeptide binding]; other site 891968004171 catalytic motif [active] 891968004172 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 891968004173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968004174 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 891968004175 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 891968004176 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968004177 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968004178 xanthine permease; Region: pbuX; TIGR03173 891968004179 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 891968004180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968004181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968004182 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 891968004183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968004184 catalytic loop [active] 891968004185 iron binding site [ion binding]; other site 891968004186 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968004187 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 891968004188 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 891968004189 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 891968004190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968004191 active site 891968004192 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 891968004193 nucleoside/Zn binding site; other site 891968004194 dimer interface [polypeptide binding]; other site 891968004195 catalytic motif [active] 891968004196 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 891968004197 Na binding site [ion binding]; other site 891968004198 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 891968004199 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968004200 catalytic loop [active] 891968004201 iron binding site [ion binding]; other site 891968004202 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968004203 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 891968004204 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 891968004205 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 891968004206 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968004207 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968004208 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 891968004209 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 891968004210 phosphate binding site [ion binding]; other site 891968004211 4Fe-4S binding domain; Region: Fer4_6; pfam12837 891968004212 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004213 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 891968004214 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 891968004215 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 891968004216 peptidase; Reviewed; Region: PRK13004 891968004217 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 891968004218 putative metal binding site [ion binding]; other site 891968004219 putative dimer interface [polypeptide binding]; other site 891968004220 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 891968004221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968004222 threonine synthase; Validated; Region: PRK06260 891968004223 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 891968004224 homodimer interface [polypeptide binding]; other site 891968004225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968004226 catalytic residue [active] 891968004227 peptidase; Reviewed; Region: PRK13004 891968004228 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 891968004229 metal binding site [ion binding]; metal-binding site 891968004230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 891968004231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 891968004232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 891968004233 dimerization interface [polypeptide binding]; other site 891968004234 AIR carboxylase; Region: AIRC; pfam00731 891968004235 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 891968004236 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 891968004237 dimer interface [polypeptide binding]; other site 891968004238 active site 891968004239 glycine-pyridoxal phosphate binding site [chemical binding]; other site 891968004240 folate binding site [chemical binding]; other site 891968004241 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 891968004242 intersubunit interface [polypeptide binding]; other site 891968004243 active site 891968004244 catalytic residue [active] 891968004245 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 891968004246 amino acid carrier protein; Region: agcS; TIGR00835 891968004247 B12 binding domain; Region: B12-binding; pfam02310 891968004248 B12 binding site [chemical binding]; other site 891968004249 Radical SAM superfamily; Region: Radical_SAM; pfam04055 891968004250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968004251 FeS/SAM binding site; other site 891968004252 argininosuccinate synthase; Provisional; Region: PRK13820 891968004253 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 891968004254 ANP binding site [chemical binding]; other site 891968004255 Substrate Binding Site II [chemical binding]; other site 891968004256 Substrate Binding Site I [chemical binding]; other site 891968004257 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 891968004258 Malic enzyme, N-terminal domain; Region: malic; pfam00390 891968004259 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 891968004260 putative NAD(P) binding site [chemical binding]; other site 891968004261 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 891968004262 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 891968004263 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 891968004264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 891968004265 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 891968004266 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 891968004267 substrate binding site [chemical binding]; other site 891968004268 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 891968004269 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 891968004270 substrate binding site [chemical binding]; other site 891968004271 ligand binding site [chemical binding]; other site 891968004272 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968004273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968004274 DNA-binding site [nucleotide binding]; DNA binding site 891968004275 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 891968004276 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 891968004277 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 891968004278 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 891968004279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 891968004280 Peptidase family C69; Region: Peptidase_C69; cl17793 891968004281 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 891968004282 active site 891968004283 Zn binding site [ion binding]; other site 891968004284 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 891968004285 active site 891968004286 Peptidase family C69; Region: Peptidase_C69; cl17793 891968004287 Transcriptional regulators [Transcription]; Region: GntR; COG1802 891968004288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968004289 DNA-binding site [nucleotide binding]; DNA binding site 891968004290 FCD domain; Region: FCD; pfam07729 891968004291 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 891968004292 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 891968004293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968004294 catalytic residue [active] 891968004295 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 891968004296 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 891968004297 trimerization site [polypeptide binding]; other site 891968004298 active site 891968004299 MOSC domain; Region: MOSC; pfam03473 891968004300 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 891968004301 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 891968004302 TPP-binding site [chemical binding]; other site 891968004303 putative dimer interface [polypeptide binding]; other site 891968004304 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 891968004305 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968004306 dimer interface [polypeptide binding]; other site 891968004307 PYR/PP interface [polypeptide binding]; other site 891968004308 TPP binding site [chemical binding]; other site 891968004309 substrate binding site [chemical binding]; other site 891968004310 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968004311 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 891968004312 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 891968004313 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004314 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 891968004315 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 891968004316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968004317 Walker A motif; other site 891968004318 ATP binding site [chemical binding]; other site 891968004319 Walker B motif; other site 891968004320 arginine finger; other site 891968004321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968004322 Walker A motif; other site 891968004323 ATP binding site [chemical binding]; other site 891968004324 Walker B motif; other site 891968004325 arginine finger; other site 891968004326 L-lactate permease; Region: Lactate_perm; cl00701 891968004327 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 891968004328 Isochorismatase family; Region: Isochorismatase; pfam00857 891968004329 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 891968004330 catalytic triad [active] 891968004331 conserved cis-peptide bond; other site 891968004332 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 891968004333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968004334 S-adenosylmethionine binding site [chemical binding]; other site 891968004335 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 891968004336 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 891968004337 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 891968004338 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 891968004339 hypothetical protein; Reviewed; Region: PRK09588 891968004340 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 891968004341 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 891968004342 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 891968004343 Peptidase family M50; Region: Peptidase_M50; pfam02163 891968004344 active site 891968004345 putative substrate binding region [chemical binding]; other site 891968004346 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 891968004347 DHH family; Region: DHH; pfam01368 891968004348 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 891968004349 FOG: CBS domain [General function prediction only]; Region: COG0517 891968004350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 891968004351 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 891968004352 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 891968004353 active site 891968004354 NTP binding site [chemical binding]; other site 891968004355 metal binding triad [ion binding]; metal-binding site 891968004356 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 891968004357 dephospho-CoA kinase; Region: TIGR00152 891968004358 CoA-binding site [chemical binding]; other site 891968004359 ATP-binding [chemical binding]; other site 891968004360 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 891968004361 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 891968004362 Part of AAA domain; Region: AAA_19; pfam13245 891968004363 Family description; Region: UvrD_C_2; pfam13538 891968004364 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 891968004365 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 891968004366 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 891968004367 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 891968004368 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 891968004369 30S subunit binding site; other site 891968004370 aspartate aminotransferase; Provisional; Region: PRK05764 891968004371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968004372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968004373 homodimer interface [polypeptide binding]; other site 891968004374 catalytic residue [active] 891968004375 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 891968004376 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 891968004377 putative substrate binding site [chemical binding]; other site 891968004378 nucleotide binding site [chemical binding]; other site 891968004379 nucleotide binding site [chemical binding]; other site 891968004380 homodimer interface [polypeptide binding]; other site 891968004381 ribosome recycling factor; Reviewed; Region: frr; PRK00083 891968004382 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 891968004383 hinge region; other site 891968004384 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 891968004385 putative nucleotide binding site [chemical binding]; other site 891968004386 uridine monophosphate binding site [chemical binding]; other site 891968004387 homohexameric interface [polypeptide binding]; other site 891968004388 elongation factor Ts; Reviewed; Region: tsf; PRK12332 891968004389 UBA/TS-N domain; Region: UBA; pfam00627 891968004390 Elongation factor TS; Region: EF_TS; pfam00889 891968004391 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 891968004392 rRNA interaction site [nucleotide binding]; other site 891968004393 S8 interaction site; other site 891968004394 putative laminin-1 binding site; other site 891968004395 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 891968004396 putative homodimer interface [polypeptide binding]; other site 891968004397 putative homotetramer interface [polypeptide binding]; other site 891968004398 putative allosteric switch controlling residues; other site 891968004399 putative metal binding site [ion binding]; other site 891968004400 putative homodimer-homodimer interface [polypeptide binding]; other site 891968004401 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 891968004402 nucleoside/Zn binding site; other site 891968004403 dimer interface [polypeptide binding]; other site 891968004404 catalytic motif [active] 891968004405 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 891968004406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 891968004407 non-specific DNA binding site [nucleotide binding]; other site 891968004408 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 891968004409 salt bridge; other site 891968004410 sequence-specific DNA binding site [nucleotide binding]; other site 891968004411 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 891968004412 Catalytic site [active] 891968004413 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 891968004414 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 891968004415 active site 891968004416 DNA binding site [nucleotide binding] 891968004417 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 891968004418 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 891968004419 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 891968004420 Catalytic site [active] 891968004421 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 891968004422 AAA ATPase domain; Region: AAA_16; pfam13191 891968004423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 891968004424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 891968004425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 891968004426 binding surface 891968004427 TPR motif; other site 891968004428 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 891968004429 active sites [active] 891968004430 tetramer interface [polypeptide binding]; other site 891968004431 Predicted membrane protein [Function unknown]; Region: COG1288 891968004432 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 891968004433 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 891968004434 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 891968004435 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 891968004436 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 891968004437 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 891968004438 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 891968004439 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 891968004440 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 891968004441 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968004442 dimer interface [polypeptide binding]; other site 891968004443 PYR/PP interface [polypeptide binding]; other site 891968004444 TPP binding site [chemical binding]; other site 891968004445 substrate binding site [chemical binding]; other site 891968004446 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 891968004447 TPP-binding site; other site 891968004448 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004449 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 891968004450 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 891968004451 SurA N-terminal domain; Region: SurA_N; pfam09312 891968004452 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 891968004453 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 891968004454 ABC1 family; Region: ABC1; cl17513 891968004455 DNA polymerase I; Provisional; Region: PRK05755 891968004456 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 891968004457 active site 891968004458 metal binding site 1 [ion binding]; metal-binding site 891968004459 putative 5' ssDNA interaction site; other site 891968004460 metal binding site 3; metal-binding site 891968004461 metal binding site 2 [ion binding]; metal-binding site 891968004462 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 891968004463 putative DNA binding site [nucleotide binding]; other site 891968004464 putative metal binding site [ion binding]; other site 891968004465 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 891968004466 active site 891968004467 DNA binding site [nucleotide binding] 891968004468 catalytic site [active] 891968004469 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 891968004470 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 891968004471 active site 891968004472 HIGH motif; other site 891968004473 KMSKS motif; other site 891968004474 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 891968004475 4Fe-4S binding domain; Region: Fer4_6; pfam12837 891968004476 NADH dehydrogenase; Region: NADHdh; cl00469 891968004477 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 891968004478 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 891968004479 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 891968004480 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 891968004481 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 891968004482 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08376 891968004483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 891968004484 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 891968004485 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK08386 891968004486 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 891968004487 hypothetical protein; Provisional; Region: PRK08378 891968004488 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12672 891968004489 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 891968004490 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 891968004491 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 891968004492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 891968004493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968004494 Walker A/P-loop; other site 891968004495 ATP binding site [chemical binding]; other site 891968004496 Q-loop/lid; other site 891968004497 ABC transporter signature motif; other site 891968004498 Walker B; other site 891968004499 D-loop; other site 891968004500 H-loop/switch region; other site 891968004501 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 891968004502 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 891968004503 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 891968004504 SmpB-tmRNA interface; other site 891968004505 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 891968004506 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 891968004507 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 891968004508 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 891968004509 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968004510 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 891968004511 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 891968004512 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 891968004513 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 891968004514 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 891968004515 thiS-thiF/thiG interaction site; other site 891968004516 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 891968004517 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 891968004518 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 891968004519 Isochorismatase family; Region: Isochorismatase; pfam00857 891968004520 catalytic triad [active] 891968004521 dimer interface [polypeptide binding]; other site 891968004522 conserved cis-peptide bond; other site 891968004523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 891968004524 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 891968004525 Malic enzyme, N-terminal domain; Region: malic; pfam00390 891968004526 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 891968004527 NAD(P) binding pocket [chemical binding]; other site 891968004528 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 891968004529 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 891968004530 DNA binding site [nucleotide binding] 891968004531 active site 891968004532 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 891968004533 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 891968004534 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 891968004535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968004536 active site 891968004537 motif I; other site 891968004538 motif II; other site 891968004539 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 891968004540 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 891968004541 NADP-binding site; other site 891968004542 homotetramer interface [polypeptide binding]; other site 891968004543 substrate binding site [chemical binding]; other site 891968004544 homodimer interface [polypeptide binding]; other site 891968004545 active site 891968004546 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 891968004547 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 891968004548 Substrate binding site; other site 891968004549 Mg++ binding site; other site 891968004550 metal-binding site 891968004551 Mg++ binding site; other site 891968004552 metal-binding site 891968004553 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 891968004554 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 891968004555 dimer interface [polypeptide binding]; other site 891968004556 active site 891968004557 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 891968004558 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 891968004559 putative active site [active] 891968004560 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 891968004561 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 891968004562 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 891968004563 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 891968004564 Na binding site [ion binding]; other site 891968004565 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 891968004566 classical (c) SDRs; Region: SDR_c; cd05233 891968004567 NAD(P) binding site [chemical binding]; other site 891968004568 active site 891968004569 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 891968004570 ATP-NAD kinase; Region: NAD_kinase; pfam01513 891968004571 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 891968004572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968004573 catalytic residue [active] 891968004574 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 891968004575 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 891968004576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968004577 catalytic residue [active] 891968004578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968004579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968004580 DNA-binding site [nucleotide binding]; DNA binding site 891968004581 FCD domain; Region: FCD; pfam07729 891968004582 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 891968004583 Ligand Binding Site [chemical binding]; other site 891968004584 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 891968004585 active site 891968004586 catalytic motif [active] 891968004587 Zn binding site [ion binding]; other site 891968004588 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 891968004589 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 891968004590 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 891968004591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968004592 Walker A/P-loop; other site 891968004593 ATP binding site [chemical binding]; other site 891968004594 Q-loop/lid; other site 891968004595 ABC transporter signature motif; other site 891968004596 Walker B; other site 891968004597 D-loop; other site 891968004598 H-loop/switch region; other site 891968004599 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 891968004600 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 891968004601 active site 891968004602 dimer interface [polypeptide binding]; other site 891968004603 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 891968004604 dimer interface [polypeptide binding]; other site 891968004605 active site 891968004606 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 891968004607 catalytic residues [active] 891968004608 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 891968004609 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 891968004610 putative dimer interface [polypeptide binding]; other site 891968004611 [2Fe-2S] cluster binding site [ion binding]; other site 891968004612 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 891968004613 dimer interface [polypeptide binding]; other site 891968004614 [2Fe-2S] cluster binding site [ion binding]; other site 891968004615 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 891968004616 SLBB domain; Region: SLBB; pfam10531 891968004617 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 891968004618 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004619 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 891968004620 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968004622 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 891968004623 catalytic loop [active] 891968004624 iron binding site [ion binding]; other site 891968004625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 891968004626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968004627 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968004628 4Fe-4S binding domain; Region: Fer4; pfam00037 891968004629 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968004630 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 891968004631 molybdopterin cofactor binding site; other site 891968004632 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 891968004633 elongation factor G; Reviewed; Region: PRK12740 891968004634 G1 box; other site 891968004635 putative GEF interaction site [polypeptide binding]; other site 891968004636 GTP/Mg2+ binding site [chemical binding]; other site 891968004637 Switch I region; other site 891968004638 G2 box; other site 891968004639 G3 box; other site 891968004640 Switch II region; other site 891968004641 G4 box; other site 891968004642 G5 box; other site 891968004643 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 891968004644 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 891968004645 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 891968004646 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 891968004647 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 891968004648 GatB domain; Region: GatB_Yqey; smart00845 891968004649 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 891968004650 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 891968004651 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 891968004652 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 891968004653 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 891968004654 nucleotide binding pocket [chemical binding]; other site 891968004655 K-X-D-G motif; other site 891968004656 catalytic site [active] 891968004657 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 891968004658 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 891968004659 Helix-hairpin-helix motif; Region: HHH; pfam00633 891968004660 helix-hairpin-helix signature motif; other site 891968004661 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 891968004662 Dimer interface [polypeptide binding]; other site 891968004663 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 891968004664 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 891968004665 dimer interface [polypeptide binding]; other site 891968004666 putative anticodon binding site; other site 891968004667 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 891968004668 motif 1; other site 891968004669 active site 891968004670 motif 2; other site 891968004671 motif 3; other site 891968004672 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 891968004673 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 891968004674 FMN binding site [chemical binding]; other site 891968004675 active site 891968004676 catalytic residues [active] 891968004677 substrate binding site [chemical binding]; other site 891968004678 pantothenate kinase; Reviewed; Region: PRK13318 891968004679 Competence protein; Region: Competence; pfam03772 891968004680 SLBB domain; Region: SLBB; pfam10531 891968004681 comEA protein; Region: comE; TIGR01259 891968004682 Helix-hairpin-helix motif; Region: HHH; pfam00633 891968004683 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 891968004684 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 891968004685 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 891968004686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968004687 FeS/SAM binding site; other site 891968004688 TRAM domain; Region: TRAM; pfam01938 891968004689 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 891968004690 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 891968004691 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 891968004692 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 891968004693 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 891968004694 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968004695 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 891968004696 CTP synthetase; Validated; Region: pyrG; PRK05380 891968004697 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 891968004698 Catalytic site [active] 891968004699 active site 891968004700 UTP binding site [chemical binding]; other site 891968004701 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 891968004702 active site 891968004703 putative oxyanion hole; other site 891968004704 catalytic triad [active] 891968004705 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 891968004706 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 891968004707 active site 891968004708 substrate binding site [chemical binding]; other site 891968004709 metal binding site [ion binding]; metal-binding site 891968004710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 891968004711 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 891968004712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 891968004713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 891968004714 Peptidase family M23; Region: Peptidase_M23; pfam01551 891968004715 transcription termination factor Rho; Provisional; Region: rho; PRK09376 891968004716 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 891968004717 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 891968004718 RNA binding site [nucleotide binding]; other site 891968004719 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 891968004720 Walker A motif; other site 891968004721 ATP binding site [chemical binding]; other site 891968004722 Walker B motif; other site 891968004723 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 891968004724 active site 891968004725 intersubunit interactions; other site 891968004726 catalytic residue [active] 891968004727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968004728 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968004729 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 891968004730 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 891968004731 Walker A/P-loop; other site 891968004732 ATP binding site [chemical binding]; other site 891968004733 Q-loop/lid; other site 891968004734 ABC transporter signature motif; other site 891968004735 Walker B; other site 891968004736 D-loop; other site 891968004737 H-loop/switch region; other site 891968004738 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 891968004739 cobalt transport protein CbiM; Validated; Region: PRK06265 891968004740 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 891968004741 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 891968004742 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 891968004743 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 891968004744 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 891968004745 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 891968004746 homotrimer interaction site [polypeptide binding]; other site 891968004747 putative active site [active] 891968004748 Domain of unknown function DUF77; Region: DUF77; pfam01910 891968004749 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 891968004750 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 891968004751 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 891968004752 active site 891968004753 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 891968004754 Clp amino terminal domain; Region: Clp_N; pfam02861 891968004755 Clp amino terminal domain; Region: Clp_N; pfam02861 891968004756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968004757 Walker A motif; other site 891968004758 ATP binding site [chemical binding]; other site 891968004759 Walker B motif; other site 891968004760 arginine finger; other site 891968004761 UvrB/uvrC motif; Region: UVR; pfam02151 891968004762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968004763 Walker A motif; other site 891968004764 ATP binding site [chemical binding]; other site 891968004765 Walker B motif; other site 891968004766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 891968004767 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 891968004768 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 891968004769 ADP binding site [chemical binding]; other site 891968004770 phosphagen binding site; other site 891968004771 substrate specificity loop; other site 891968004772 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 891968004773 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 891968004774 Predicted membrane protein [Function unknown]; Region: COG1971 891968004775 Domain of unknown function DUF; Region: DUF204; pfam02659 891968004776 Domain of unknown function DUF; Region: DUF204; pfam02659 891968004777 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 891968004778 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 891968004779 CoA binding domain; Region: CoA_binding_2; pfam13380 891968004780 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 891968004781 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 891968004782 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 891968004783 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 891968004784 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 891968004785 active site 891968004786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 891968004787 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 891968004788 NAD binding site [chemical binding]; other site 891968004789 homodimer interface [polypeptide binding]; other site 891968004790 active site 891968004791 putative substrate binding site [chemical binding]; other site 891968004792 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 891968004793 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 891968004794 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 891968004795 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 891968004796 RimM N-terminal domain; Region: RimM; pfam01782 891968004797 KH domain; Region: KH_4; pfam13083 891968004798 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 891968004799 signal recognition particle protein; Provisional; Region: PRK10867 891968004800 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 891968004801 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 891968004802 P loop; other site 891968004803 GTP binding site [chemical binding]; other site 891968004804 Signal peptide binding domain; Region: SRP_SPB; pfam02978 891968004805 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 891968004806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 891968004807 glyoxylate reductase; Reviewed; Region: PRK13243 891968004808 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 891968004809 dimerization interface [polypeptide binding]; other site 891968004810 ligand binding site [chemical binding]; other site 891968004811 NADP binding site [chemical binding]; other site 891968004812 catalytic site [active] 891968004813 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968004814 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968004815 metal binding site [ion binding]; metal-binding site 891968004816 dimer interface [polypeptide binding]; other site 891968004817 Predicted membrane protein [Function unknown]; Region: COG1288 891968004818 Pantoate-beta-alanine ligase; Region: PanC; cd00560 891968004819 pantoate--beta-alanine ligase; Region: panC; TIGR00018 891968004820 active site 891968004821 ATP-binding site [chemical binding]; other site 891968004822 pantoate-binding site; other site 891968004823 HXXH motif; other site 891968004824 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 891968004825 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 891968004826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968004827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968004828 active site 891968004829 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 891968004830 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 891968004831 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 891968004832 Walker A/P-loop; other site 891968004833 ATP binding site [chemical binding]; other site 891968004834 Q-loop/lid; other site 891968004835 ABC transporter signature motif; other site 891968004836 Walker B; other site 891968004837 D-loop; other site 891968004838 H-loop/switch region; other site 891968004839 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 891968004840 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 891968004841 Walker A/P-loop; other site 891968004842 ATP binding site [chemical binding]; other site 891968004843 Q-loop/lid; other site 891968004844 ABC transporter signature motif; other site 891968004845 Walker B; other site 891968004846 D-loop; other site 891968004847 H-loop/switch region; other site 891968004848 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 891968004849 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 891968004850 TM-ABC transporter signature motif; other site 891968004851 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968004852 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 891968004853 TM-ABC transporter signature motif; other site 891968004854 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 891968004855 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 891968004856 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 891968004857 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 891968004858 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 891968004859 active site 891968004860 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 891968004861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 891968004862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968004863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 891968004864 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 891968004865 active site residue [active] 891968004866 Sulphur transport; Region: Sulf_transp; pfam04143 891968004867 PAS domain; Region: PAS; smart00091 891968004868 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 891968004869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 891968004870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 891968004871 metal binding site [ion binding]; metal-binding site 891968004872 active site 891968004873 I-site; other site 891968004874 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 891968004875 PBP superfamily domain; Region: PBP_like_2; cl17296 891968004876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 891968004877 Nucleoside recognition; Region: Gate; pfam07670 891968004878 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 891968004879 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 891968004880 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 891968004881 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 891968004882 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 891968004883 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 891968004884 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 891968004885 Active Sites [active] 891968004886 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968004887 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 891968004888 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 891968004889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 891968004890 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 891968004891 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 891968004892 active site 891968004893 homotetramer interface [polypeptide binding]; other site 891968004894 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 891968004895 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 891968004896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968004897 FeS/SAM binding site; other site 891968004898 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 891968004899 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 891968004900 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 891968004901 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 891968004902 oligomerization interface [polypeptide binding]; other site 891968004903 active site 891968004904 metal binding site [ion binding]; metal-binding site 891968004905 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 891968004906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 891968004907 Predicted amidohydrolase [General function prediction only]; Region: COG0388 891968004908 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 891968004909 putative active site [active] 891968004910 catalytic triad [active] 891968004911 putative dimer interface [polypeptide binding]; other site 891968004912 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 891968004913 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 891968004914 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 891968004915 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 891968004916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968004917 catalytic residue [active] 891968004918 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 891968004919 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 891968004920 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 891968004921 active site 891968004922 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 891968004923 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 891968004924 SxDxEG motif; other site 891968004925 active site 891968004926 metal binding site [ion binding]; metal-binding site 891968004927 homopentamer interface [polypeptide binding]; other site 891968004928 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 891968004929 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 891968004930 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 891968004931 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 891968004932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 891968004933 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 891968004934 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 891968004935 Family of unknown function (DUF694); Region: DUF694; pfam05107 891968004936 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 891968004937 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 891968004938 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 891968004939 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 891968004940 GMP synthase; Reviewed; Region: guaA; PRK00074 891968004941 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 891968004942 AMP/PPi binding site [chemical binding]; other site 891968004943 candidate oxyanion hole; other site 891968004944 catalytic triad [active] 891968004945 potential glutamine specificity residues [chemical binding]; other site 891968004946 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 891968004947 ATP Binding subdomain [chemical binding]; other site 891968004948 Ligand Binding sites [chemical binding]; other site 891968004949 Dimerization subdomain; other site 891968004950 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 891968004951 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 891968004952 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 891968004953 protein binding site [polypeptide binding]; other site 891968004954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 891968004955 protein binding site [polypeptide binding]; other site 891968004956 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 891968004957 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 891968004958 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968004959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968004960 DNA-binding site [nucleotide binding]; DNA binding site 891968004961 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 891968004962 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 891968004963 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 891968004964 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 891968004965 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 891968004966 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 891968004967 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968004968 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 891968004969 alanine dehydrogenase; Validated; Region: PRK06046 891968004970 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 891968004971 alanine dehydrogenase; Validated; Region: PRK06046 891968004972 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 891968004973 DctM-like transporters; Region: DctM; pfam06808 891968004974 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968004975 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 891968004976 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 891968004977 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 891968004978 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 891968004979 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 891968004980 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 891968004981 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 891968004982 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 891968004983 putative active site [active] 891968004984 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 891968004985 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 891968004986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968004987 FeS/SAM binding site; other site 891968004988 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 891968004989 metal-dependent hydrolase; Provisional; Region: PRK00685 891968004990 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968004991 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 891968004992 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 891968004993 dimer interface [polypeptide binding]; other site 891968004994 anticodon binding site; other site 891968004995 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 891968004996 homodimer interface [polypeptide binding]; other site 891968004997 motif 1; other site 891968004998 active site 891968004999 motif 2; other site 891968005000 GAD domain; Region: GAD; pfam02938 891968005001 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 891968005002 motif 3; other site 891968005003 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 891968005004 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 891968005005 dimer interface [polypeptide binding]; other site 891968005006 motif 1; other site 891968005007 active site 891968005008 motif 2; other site 891968005009 motif 3; other site 891968005010 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 891968005011 anticodon binding site; other site 891968005012 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 891968005013 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 891968005014 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 891968005015 DNA-binding site [nucleotide binding]; DNA binding site 891968005016 RNA-binding motif; other site 891968005017 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 891968005018 dimer interface [polypeptide binding]; other site 891968005019 putative tRNA-binding site [nucleotide binding]; other site 891968005020 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 891968005021 histidinol dehydrogenase; Region: hisD; TIGR00069 891968005022 NAD binding site [chemical binding]; other site 891968005023 dimerization interface [polypeptide binding]; other site 891968005024 product binding site; other site 891968005025 substrate binding site [chemical binding]; other site 891968005026 zinc binding site [ion binding]; other site 891968005027 catalytic residues [active] 891968005028 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 891968005029 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968005030 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968005031 metal binding site [ion binding]; metal-binding site 891968005032 dimer interface [polypeptide binding]; other site 891968005033 Peptidase family M48; Region: Peptidase_M48; pfam01435 891968005034 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 891968005035 thiamine phosphate binding site [chemical binding]; other site 891968005036 active site 891968005037 pyrophosphate binding site [ion binding]; other site 891968005038 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 891968005039 substrate binding site [chemical binding]; other site 891968005040 multimerization interface [polypeptide binding]; other site 891968005041 ATP binding site [chemical binding]; other site 891968005042 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 891968005043 dimer interface [polypeptide binding]; other site 891968005044 substrate binding site [chemical binding]; other site 891968005045 ATP binding site [chemical binding]; other site 891968005046 GTP-binding protein YchF; Reviewed; Region: PRK09601 891968005047 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 891968005048 G1 box; other site 891968005049 GTP/Mg2+ binding site [chemical binding]; other site 891968005050 G2 box; other site 891968005051 Switch I region; other site 891968005052 G3 box; other site 891968005053 Switch II region; other site 891968005054 G4 box; other site 891968005055 G5 box; other site 891968005056 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 891968005057 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 891968005058 active site 891968005059 Ap4A binding cleft/pocket [chemical binding]; other site 891968005060 P4 phosphate binding site; other site 891968005061 nudix motif; other site 891968005062 putative P2/P3 phosphate binding site [ion binding]; other site 891968005063 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 891968005064 conserved hypothetical protein; Region: TIGR02231 891968005065 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 891968005066 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 891968005067 FeoA domain; Region: FeoA; pfam04023 891968005068 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 891968005069 ferrous iron transporter FeoB; Region: feoB; TIGR00437 891968005070 G1 box; other site 891968005071 GTP/Mg2+ binding site [chemical binding]; other site 891968005072 Switch I region; other site 891968005073 G2 box; other site 891968005074 G3 box; other site 891968005075 Switch II region; other site 891968005076 G4 box; other site 891968005077 G5 box; other site 891968005078 Nucleoside recognition; Region: Gate; pfam07670 891968005079 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 891968005080 Nucleoside recognition; Region: Gate; pfam07670 891968005081 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 891968005082 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 891968005083 Walker A/P-loop; other site 891968005084 ATP binding site [chemical binding]; other site 891968005085 Q-loop/lid; other site 891968005086 ABC transporter signature motif; other site 891968005087 Walker B; other site 891968005088 D-loop; other site 891968005089 H-loop/switch region; other site 891968005090 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 891968005091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 891968005092 ABC-ATPase subunit interface; other site 891968005093 dimer interface [polypeptide binding]; other site 891968005094 putative PBP binding regions; other site 891968005095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 891968005096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 891968005097 DNA binding site [nucleotide binding] 891968005098 domain linker motif; other site 891968005099 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 891968005100 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 891968005101 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 891968005102 active site 891968005103 FMN binding site [chemical binding]; other site 891968005104 substrate binding site [chemical binding]; other site 891968005105 putative catalytic residue [active] 891968005106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 891968005107 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 891968005108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 891968005109 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 891968005110 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 891968005111 active site 891968005112 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 891968005113 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 891968005114 Walker A/P-loop; other site 891968005115 ATP binding site [chemical binding]; other site 891968005116 Q-loop/lid; other site 891968005117 ABC transporter signature motif; other site 891968005118 Walker B; other site 891968005119 D-loop; other site 891968005120 H-loop/switch region; other site 891968005121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968005122 dimer interface [polypeptide binding]; other site 891968005123 conserved gate region; other site 891968005124 putative PBP binding loops; other site 891968005125 ABC-ATPase subunit interface; other site 891968005126 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 891968005127 PBP superfamily domain; Region: PBP_like_2; pfam12849 891968005128 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 891968005129 Na binding site [ion binding]; other site 891968005130 Protein of unknown function (DUF997); Region: DUF997; cl01614 891968005131 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 891968005132 transaminase; Validated; Region: PRK07324 891968005133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968005134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005135 homodimer interface [polypeptide binding]; other site 891968005136 catalytic residue [active] 891968005137 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 891968005138 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 891968005139 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 891968005140 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 891968005141 G1 box; other site 891968005142 putative GEF interaction site [polypeptide binding]; other site 891968005143 GTP/Mg2+ binding site [chemical binding]; other site 891968005144 Switch I region; other site 891968005145 G2 box; other site 891968005146 G3 box; other site 891968005147 Switch II region; other site 891968005148 G4 box; other site 891968005149 G5 box; other site 891968005150 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 891968005151 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 891968005152 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 891968005153 CoenzymeA binding site [chemical binding]; other site 891968005154 subunit interaction site [polypeptide binding]; other site 891968005155 PHB binding site; other site 891968005156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 891968005157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968005158 DNA-binding site [nucleotide binding]; DNA binding site 891968005159 FCD domain; Region: FCD; pfam07729 891968005160 Uncharacterized conserved protein [Function unknown]; Region: COG1434 891968005161 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 891968005162 putative active site [active] 891968005163 recombination factor protein RarA; Reviewed; Region: PRK13342 891968005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 891968005165 Walker A motif; other site 891968005166 ATP binding site [chemical binding]; other site 891968005167 Walker B motif; other site 891968005168 arginine finger; other site 891968005169 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 891968005170 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 891968005171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968005172 active site 891968005173 motif I; other site 891968005174 motif II; other site 891968005175 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 891968005176 nickel binding site [ion binding]; other site 891968005177 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 891968005178 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 891968005179 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 891968005180 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 891968005181 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968005182 catalytic loop [active] 891968005183 iron binding site [ion binding]; other site 891968005184 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 891968005185 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 891968005186 molybdopterin cofactor binding site; other site 891968005187 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 891968005188 dimer interface [polypeptide binding]; other site 891968005189 [2Fe-2S] cluster binding site [ion binding]; other site 891968005190 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 891968005191 SLBB domain; Region: SLBB; pfam10531 891968005192 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 891968005193 4Fe-4S binding domain; Region: Fer4; pfam00037 891968005194 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 891968005195 4Fe-4S binding domain; Region: Fer4; pfam00037 891968005196 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 891968005197 dimer interface [polypeptide binding]; other site 891968005198 [2Fe-2S] cluster binding site [ion binding]; other site 891968005199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 891968005200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968005201 ATP binding site [chemical binding]; other site 891968005202 Mg2+ binding site [ion binding]; other site 891968005203 G-X-G motif; other site 891968005204 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 891968005205 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 891968005206 putative dimer interface [polypeptide binding]; other site 891968005207 [2Fe-2S] cluster binding site [ion binding]; other site 891968005208 PHP domain; Region: PHP; pfam02811 891968005209 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 891968005210 active site 891968005211 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 891968005212 DRTGG domain; Region: DRTGG; pfam07085 891968005213 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 891968005214 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 891968005215 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 891968005216 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 891968005217 Putative Fe-S cluster; Region: FeS; cl17515 891968005218 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 891968005219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 891968005220 ATP binding site [chemical binding]; other site 891968005221 Mg2+ binding site [ion binding]; other site 891968005222 G-X-G motif; other site 891968005223 DRTGG domain; Region: DRTGG; pfam07085 891968005224 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968005225 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 891968005226 glycogen synthase; Provisional; Region: glgA; PRK00654 891968005227 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 891968005228 ADP-binding pocket [chemical binding]; other site 891968005229 homodimer interface [polypeptide binding]; other site 891968005230 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 891968005231 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 891968005232 ligand binding site; other site 891968005233 oligomer interface; other site 891968005234 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 891968005235 dimer interface [polypeptide binding]; other site 891968005236 N-terminal domain interface [polypeptide binding]; other site 891968005237 sulfate 1 binding site; other site 891968005238 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 891968005239 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 891968005240 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 891968005241 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 891968005242 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 891968005243 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 891968005244 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 891968005245 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 891968005246 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 891968005247 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 891968005248 active site 891968005249 PQQ-like domain; Region: PQQ_2; pfam13360 891968005250 Trp docking motif [polypeptide binding]; other site 891968005251 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 891968005252 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 891968005253 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 891968005254 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 891968005255 Ligand Binding Site [chemical binding]; other site 891968005256 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 891968005257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 891968005258 NAD(P) binding site [chemical binding]; other site 891968005259 active site 891968005260 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 891968005261 amino acid carrier protein; Region: agcS; TIGR00835 891968005262 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 891968005263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968005264 catalytic residue [active] 891968005265 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 891968005266 Protein export membrane protein; Region: SecD_SecF; cl14618 891968005267 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 891968005268 HlyD family secretion protein; Region: HlyD_3; pfam13437 891968005269 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 891968005270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 891968005271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 891968005272 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 891968005273 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 891968005274 23S rRNA interface [nucleotide binding]; other site 891968005275 L3 interface [polypeptide binding]; other site 891968005276 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 891968005277 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 891968005278 active site 891968005279 Preprotein translocase SecG subunit; Region: SecG; pfam03840 891968005280 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 891968005281 active site 891968005282 dimerization interface [polypeptide binding]; other site 891968005283 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 891968005284 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 891968005285 active site 891968005286 metal binding site [ion binding]; metal-binding site 891968005287 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 891968005288 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 891968005289 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 891968005290 tetramer interface [polypeptide binding]; other site 891968005291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005292 catalytic residue [active] 891968005293 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 891968005294 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 891968005295 active site 891968005296 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 891968005297 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 891968005298 putative CheA interaction surface; other site 891968005299 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 891968005300 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968005301 active site 891968005302 metal binding site [ion binding]; metal-binding site 891968005303 homotetramer interface [polypeptide binding]; other site 891968005304 homoserine dehydrogenase; Provisional; Region: PRK06270 891968005305 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 891968005306 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 891968005307 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 891968005308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 891968005309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 891968005310 dimer interface [polypeptide binding]; other site 891968005311 putative CheW interface [polypeptide binding]; other site 891968005312 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 891968005313 dimerization domain swap beta strand [polypeptide binding]; other site 891968005314 regulatory protein interface [polypeptide binding]; other site 891968005315 active site 891968005316 regulatory phosphorylation site [posttranslational modification]; other site 891968005317 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 891968005318 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 891968005319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 891968005320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968005321 Predicted dehydrogenase [General function prediction only]; Region: COG0579 891968005322 hydroxyglutarate oxidase; Provisional; Region: PRK11728 891968005323 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 891968005324 glycerol kinase; Provisional; Region: glpK; PRK00047 891968005325 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 891968005326 N- and C-terminal domain interface [polypeptide binding]; other site 891968005327 active site 891968005328 MgATP binding site [chemical binding]; other site 891968005329 catalytic site [active] 891968005330 metal binding site [ion binding]; metal-binding site 891968005331 glycerol binding site [chemical binding]; other site 891968005332 homotetramer interface [polypeptide binding]; other site 891968005333 homodimer interface [polypeptide binding]; other site 891968005334 FBP binding site [chemical binding]; other site 891968005335 protein IIAGlc interface [polypeptide binding]; other site 891968005336 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 891968005337 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 891968005338 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 891968005339 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 891968005340 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 891968005341 Pleckstrin homology-like domain; Region: PH-like; cl17171 891968005342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 891968005343 putative acyl-acceptor binding pocket; other site 891968005344 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 891968005345 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 891968005346 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 891968005347 active site 891968005348 HIGH motif; other site 891968005349 dimer interface [polypeptide binding]; other site 891968005350 KMSKS motif; other site 891968005351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 891968005352 RNA binding surface [nucleotide binding]; other site 891968005353 hypothetical protein; Provisional; Region: PRK04164 891968005354 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 891968005355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 891968005356 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 891968005357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 891968005358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968005359 active site 891968005360 phosphorylation site [posttranslational modification] 891968005361 intermolecular recognition site; other site 891968005362 dimerization interface [polypeptide binding]; other site 891968005363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 891968005364 DNA binding residues [nucleotide binding] 891968005365 dimerization interface [polypeptide binding]; other site 891968005366 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 891968005367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968005368 Walker A/P-loop; other site 891968005369 ATP binding site [chemical binding]; other site 891968005370 Q-loop/lid; other site 891968005371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968005372 ABC transporter signature motif; other site 891968005373 Walker B; other site 891968005374 D-loop; other site 891968005375 H-loop/switch region; other site 891968005376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 891968005377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968005378 active site 891968005379 metal binding site [ion binding]; metal-binding site 891968005380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 891968005381 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 891968005382 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 891968005383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968005384 active site 891968005385 phosphorylation site [posttranslational modification] 891968005386 intermolecular recognition site; other site 891968005387 dimerization interface [polypeptide binding]; other site 891968005388 4-alpha-glucanotransferase; Provisional; Region: PRK14508 891968005389 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 891968005390 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 891968005391 dimer interface [polypeptide binding]; other site 891968005392 PYR/PP interface [polypeptide binding]; other site 891968005393 TPP binding site [chemical binding]; other site 891968005394 substrate binding site [chemical binding]; other site 891968005395 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 891968005396 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 891968005397 Domain of unknown function; Region: EKR; pfam10371 891968005398 4Fe-4S binding domain; Region: Fer4_6; pfam12837 891968005399 4Fe-4S binding domain; Region: Fer4; pfam00037 891968005400 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 891968005401 TPP-binding site [chemical binding]; other site 891968005402 dimer interface [polypeptide binding]; other site 891968005403 phosphoenolpyruvate synthase; Validated; Region: PRK06464 891968005404 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 891968005405 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 891968005406 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 891968005407 Cupin domain; Region: Cupin_2; pfam07883 891968005408 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 891968005409 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 891968005410 tetramer interface [polypeptide binding]; other site 891968005411 active site 891968005412 Mg2+/Mn2+ binding site [ion binding]; other site 891968005413 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 891968005414 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 891968005415 substrate binding site [chemical binding]; other site 891968005416 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 891968005417 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 891968005418 substrate binding site [chemical binding]; other site 891968005419 ligand binding site [chemical binding]; other site 891968005420 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968005421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968005422 DNA-binding site [nucleotide binding]; DNA binding site 891968005423 FCD domain; Region: FCD; cl11656 891968005424 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 891968005425 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 891968005426 hybrid cluster protein; Provisional; Region: PRK05290 891968005427 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 891968005428 ACS interaction site; other site 891968005429 CODH interaction site; other site 891968005430 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 891968005431 hybrid metal cluster; other site 891968005432 4Fe-4S binding domain; Region: Fer4_6; pfam12837 891968005433 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 891968005434 Transcriptional regulator; Region: Rrf2; pfam02082 891968005435 Rrf2 family protein; Region: rrf2_super; TIGR00738 891968005436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 891968005437 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 891968005438 catalytic loop [active] 891968005439 iron binding site [ion binding]; other site 891968005440 hypothetical protein; Region: PHA02448 891968005441 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 891968005442 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 891968005443 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 891968005444 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 891968005445 NAD-dependent deacetylase; Provisional; Region: PRK00481 891968005446 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 891968005447 ferric uptake regulator; Provisional; Region: fur; PRK09462 891968005448 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 891968005449 metal binding site 2 [ion binding]; metal-binding site 891968005450 putative DNA binding helix; other site 891968005451 metal binding site 1 [ion binding]; metal-binding site 891968005452 dimer interface [polypeptide binding]; other site 891968005453 structural Zn2+ binding site [ion binding]; other site 891968005454 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 891968005455 putative MPT binding site; other site 891968005456 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 891968005457 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 891968005458 XdhC Rossmann domain; Region: XdhC_C; pfam13478 891968005459 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 891968005460 metal-binding site 891968005461 xanthine permease; Region: pbuX; TIGR03173 891968005462 recombinase A; Provisional; Region: recA; PRK09354 891968005463 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 891968005464 Walker A motif; other site 891968005465 ATP binding site [chemical binding]; other site 891968005466 Walker B motif; other site 891968005467 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 891968005468 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 891968005469 competence damage-inducible protein A; Provisional; Region: PRK00549 891968005470 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 891968005471 putative MPT binding site; other site 891968005472 Competence-damaged protein; Region: CinA; pfam02464 891968005473 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 891968005474 tetramer interfaces [polypeptide binding]; other site 891968005475 binuclear metal-binding site [ion binding]; other site 891968005476 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 891968005477 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 891968005478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968005479 FeS/SAM binding site; other site 891968005480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 891968005481 non-specific DNA binding site [nucleotide binding]; other site 891968005482 salt bridge; other site 891968005483 sequence-specific DNA binding site [nucleotide binding]; other site 891968005484 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 891968005485 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 891968005486 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 891968005487 substrate binding site [chemical binding]; other site 891968005488 hexamer interface [polypeptide binding]; other site 891968005489 metal binding site [ion binding]; metal-binding site 891968005490 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 891968005491 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 891968005492 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 891968005493 NusB family; Region: NusB; pfam01029 891968005494 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 891968005495 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 891968005496 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 891968005497 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 891968005498 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 891968005499 inhibitor-cofactor binding pocket; inhibition site 891968005500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005501 catalytic residue [active] 891968005502 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968005503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968005504 DNA-binding site [nucleotide binding]; DNA binding site 891968005505 FCD domain; Region: FCD; pfam07729 891968005506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 891968005507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968005508 DNA-binding site [nucleotide binding]; DNA binding site 891968005509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968005510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005511 homodimer interface [polypeptide binding]; other site 891968005512 catalytic residue [active] 891968005513 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 891968005514 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 891968005515 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 891968005516 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 891968005517 putative ribose interaction site [chemical binding]; other site 891968005518 putative ADP binding site [chemical binding]; other site 891968005519 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 891968005520 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 891968005521 acyl-activating enzyme (AAE) consensus motif; other site 891968005522 AMP binding site [chemical binding]; other site 891968005523 active site 891968005524 CoA binding site [chemical binding]; other site 891968005525 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 891968005526 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 891968005527 metal binding site [ion binding]; metal-binding site 891968005528 dimer interface [polypeptide binding]; other site 891968005529 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 891968005530 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 891968005531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 891968005532 RNA binding surface [nucleotide binding]; other site 891968005533 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 891968005534 active site 891968005535 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 891968005536 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 891968005537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 891968005538 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 891968005539 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 891968005540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968005541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005542 homodimer interface [polypeptide binding]; other site 891968005543 catalytic residue [active] 891968005544 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 891968005545 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 891968005546 trmE is a tRNA modification GTPase; Region: trmE; cd04164 891968005547 G1 box; other site 891968005548 GTP/Mg2+ binding site [chemical binding]; other site 891968005549 Switch I region; other site 891968005550 G2 box; other site 891968005551 Switch II region; other site 891968005552 G3 box; other site 891968005553 G4 box; other site 891968005554 G5 box; other site 891968005555 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 891968005556 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 891968005557 Flavoprotein; Region: Flavoprotein; pfam02441 891968005558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 891968005559 putative substrate translocation pore; other site 891968005560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 891968005561 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 891968005562 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 891968005563 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 891968005564 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 891968005565 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 891968005566 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 891968005567 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 891968005568 active site 891968005569 ribulose/triose binding site [chemical binding]; other site 891968005570 phosphate binding site [ion binding]; other site 891968005571 substrate (anthranilate) binding pocket [chemical binding]; other site 891968005572 product (indole) binding pocket [chemical binding]; other site 891968005573 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 891968005574 active site 891968005575 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 891968005576 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 891968005577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005578 catalytic residue [active] 891968005579 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 891968005580 substrate binding site [chemical binding]; other site 891968005581 active site 891968005582 catalytic residues [active] 891968005583 heterodimer interface [polypeptide binding]; other site 891968005584 hypothetical protein; Provisional; Region: PRK05463 891968005585 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 891968005586 putative active site [active] 891968005587 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 891968005588 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 891968005589 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 891968005590 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 891968005591 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 891968005592 putative ADP-ribose binding site [chemical binding]; other site 891968005593 prolyl-tRNA synthetase; Provisional; Region: PRK08661 891968005594 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 891968005595 dimer interface [polypeptide binding]; other site 891968005596 motif 1; other site 891968005597 active site 891968005598 motif 2; other site 891968005599 motif 3; other site 891968005600 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 891968005601 anticodon binding site; other site 891968005602 zinc-binding site [ion binding]; other site 891968005603 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 891968005604 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 891968005605 catalytic residues [active] 891968005606 Predicted permeases [General function prediction only]; Region: COG0679 891968005607 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 891968005608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968005609 ATP binding site [chemical binding]; other site 891968005610 putative Mg++ binding site [ion binding]; other site 891968005611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968005612 nucleotide binding region [chemical binding]; other site 891968005613 ATP-binding site [chemical binding]; other site 891968005614 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 891968005615 RNase_H superfamily; Region: RNase_H_2; pfam13482 891968005616 active site 891968005617 substrate binding site [chemical binding]; other site 891968005618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 891968005619 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 891968005620 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 891968005621 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 891968005622 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 891968005623 putative ligand binding site [chemical binding]; other site 891968005624 putative NAD binding site [chemical binding]; other site 891968005625 catalytic site [active] 891968005626 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 891968005627 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 891968005628 N- and C-terminal domain interface [polypeptide binding]; other site 891968005629 active site 891968005630 catalytic site [active] 891968005631 metal binding site [ion binding]; metal-binding site 891968005632 carbohydrate binding site [chemical binding]; other site 891968005633 ATP binding site [chemical binding]; other site 891968005634 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 891968005635 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 891968005636 Na binding site [ion binding]; other site 891968005637 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 891968005638 Protein of unknown function (DUF458); Region: DUF458; pfam04308 891968005639 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 891968005640 metal-binding site [ion binding] 891968005641 oligoendopeptidase F; Region: pepF; TIGR00181 891968005642 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 891968005643 active site 891968005644 Zn binding site [ion binding]; other site 891968005645 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 891968005646 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 891968005647 metal-binding site [ion binding] 891968005648 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 891968005649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 891968005650 Soluble P-type ATPase [General function prediction only]; Region: COG4087 891968005651 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 891968005652 dimer interface [polypeptide binding]; other site 891968005653 homoserine dehydrogenase; Provisional; Region: PRK06270 891968005654 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 891968005655 NAD(P) binding pocket [chemical binding]; other site 891968005656 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 891968005657 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 891968005658 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 891968005659 active site 891968005660 intersubunit interface [polypeptide binding]; other site 891968005661 catalytic residue [active] 891968005662 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 891968005663 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 891968005664 substrate binding site [chemical binding]; other site 891968005665 ATP binding site [chemical binding]; other site 891968005666 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968005667 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968005668 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 891968005669 DctM-like transporters; Region: DctM; pfam06808 891968005670 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968005671 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 891968005672 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 891968005673 putative NAD(P) binding site [chemical binding]; other site 891968005674 catalytic Zn binding site [ion binding]; other site 891968005675 structural Zn binding site [ion binding]; other site 891968005676 altronate oxidoreductase; Provisional; Region: PRK03643 891968005677 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 891968005678 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 891968005679 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 891968005680 galactarate dehydratase; Region: galactar-dH20; TIGR03248 891968005681 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 891968005682 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 891968005683 Transcriptional regulator [Transcription]; Region: IclR; COG1414 891968005684 Bacterial transcriptional regulator; Region: IclR; pfam01614 891968005685 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 891968005686 Na2 binding site [ion binding]; other site 891968005687 putative substrate binding site 1 [chemical binding]; other site 891968005688 Na binding site 1 [ion binding]; other site 891968005689 putative substrate binding site 2 [chemical binding]; other site 891968005690 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 891968005691 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 891968005692 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 891968005693 dimer interface [polypeptide binding]; other site 891968005694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005695 catalytic residue [active] 891968005696 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 891968005697 serine O-acetyltransferase; Region: cysE; TIGR01172 891968005698 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 891968005699 trimer interface [polypeptide binding]; other site 891968005700 active site 891968005701 substrate binding site [chemical binding]; other site 891968005702 CoA binding site [chemical binding]; other site 891968005703 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 891968005704 dimer interface [polypeptide binding]; other site 891968005705 catalytic triad [active] 891968005706 peroxidatic and resolving cysteines [active] 891968005707 butyrate kinase; Provisional; Region: PRK03011 891968005708 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 891968005709 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 891968005710 butyrate kinase; Provisional; Region: PRK03011 891968005711 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 891968005712 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 891968005713 homodimer interface [polypeptide binding]; other site 891968005714 substrate-cofactor binding pocket; other site 891968005715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005716 catalytic residue [active] 891968005717 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 891968005718 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 891968005719 homodimer interface [polypeptide binding]; other site 891968005720 substrate-cofactor binding pocket; other site 891968005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005722 catalytic residue [active] 891968005723 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 891968005724 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 891968005725 AAA domain; Region: AAA_33; pfam13671 891968005726 hypothetical protein; Provisional; Region: PRK06762 891968005727 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 891968005728 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 891968005729 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968005730 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 891968005731 ATP-grasp domain; Region: ATP-grasp_4; cl17255 891968005732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 891968005733 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 891968005734 Coenzyme A binding pocket [chemical binding]; other site 891968005735 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 891968005736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 891968005737 FeS/SAM binding site; other site 891968005738 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 891968005739 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 891968005740 Transposase, Mutator family; Region: Transposase_mut; pfam00872 891968005741 MULE transposase domain; Region: MULE; pfam10551 891968005742 Uncharacterized conserved protein [Function unknown]; Region: COG1479 891968005743 Protein of unknown function DUF262; Region: DUF262; pfam03235 891968005744 Uncharacterized conserved protein [Function unknown]; Region: COG3472 891968005745 PglZ domain; Region: PglZ; pfam08665 891968005746 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 891968005747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 891968005748 ATP binding site [chemical binding]; other site 891968005749 putative Mg++ binding site [ion binding]; other site 891968005750 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 891968005751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 891968005752 nucleotide binding region [chemical binding]; other site 891968005753 ATP-binding site [chemical binding]; other site 891968005754 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 891968005755 DNA methylase; Region: N6_N4_Mtase; cl17433 891968005756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 891968005757 Walker A motif; other site 891968005758 ATP binding site [chemical binding]; other site 891968005759 Walker B motif; other site 891968005760 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 891968005761 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 891968005762 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 891968005763 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 891968005764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 891968005765 dimerization interface [polypeptide binding]; other site 891968005766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 891968005767 dimer interface [polypeptide binding]; other site 891968005768 phosphorylation site [posttranslational modification] 891968005769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 891968005770 ATP binding site [chemical binding]; other site 891968005771 Mg2+ binding site [ion binding]; other site 891968005772 G-X-G motif; other site 891968005773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 891968005774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 891968005775 active site 891968005776 phosphorylation site [posttranslational modification] 891968005777 intermolecular recognition site; other site 891968005778 dimerization interface [polypeptide binding]; other site 891968005779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 891968005780 DNA binding site [nucleotide binding] 891968005781 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 891968005782 Ligand binding site; other site 891968005783 Putative Catalytic site; other site 891968005784 DXD motif; other site 891968005785 Predicted membrane protein [Function unknown]; Region: COG2246 891968005786 GtrA-like protein; Region: GtrA; pfam04138 891968005787 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 891968005788 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 891968005789 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 891968005790 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 891968005791 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 891968005792 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 891968005793 NADP-binding site; other site 891968005794 homotetramer interface [polypeptide binding]; other site 891968005795 substrate binding site [chemical binding]; other site 891968005796 homodimer interface [polypeptide binding]; other site 891968005797 active site 891968005798 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 891968005799 Ligand binding site; other site 891968005800 Putative Catalytic site; other site 891968005801 DXD motif; other site 891968005802 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 891968005803 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 891968005804 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 891968005805 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 891968005806 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 891968005807 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 891968005808 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 891968005809 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 891968005810 putative substrate binding site [chemical binding]; other site 891968005811 putative ATP binding site [chemical binding]; other site 891968005812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 891968005813 active site 891968005814 phosphorylation site [posttranslational modification] 891968005815 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 891968005816 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 891968005817 active site 891968005818 P-loop; other site 891968005819 phosphorylation site [posttranslational modification] 891968005820 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 891968005821 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 891968005822 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 891968005823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968005824 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 891968005825 Walker A/P-loop; other site 891968005826 ATP binding site [chemical binding]; other site 891968005827 Q-loop/lid; other site 891968005828 ABC transporter signature motif; other site 891968005829 Walker B; other site 891968005830 D-loop; other site 891968005831 H-loop/switch region; other site 891968005832 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 891968005833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968005834 dimer interface [polypeptide binding]; other site 891968005835 conserved gate region; other site 891968005836 putative PBP binding loops; other site 891968005837 ABC-ATPase subunit interface; other site 891968005838 phenylhydantoinase; Validated; Region: PRK08323 891968005839 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968005840 active site 891968005841 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 891968005842 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968005843 putative active site [active] 891968005844 putative metal binding site [ion binding]; other site 891968005845 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 891968005846 putative catalytic site [active] 891968005847 putative phosphate binding site [ion binding]; other site 891968005848 active site 891968005849 metal binding site A [ion binding]; metal-binding site 891968005850 DNA binding site [nucleotide binding] 891968005851 putative AP binding site [nucleotide binding]; other site 891968005852 putative metal binding site B [ion binding]; other site 891968005853 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 891968005854 EamA-like transporter family; Region: EamA; pfam00892 891968005855 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 891968005856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 891968005857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968005858 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 891968005859 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 891968005860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968005861 catalytic residue [active] 891968005862 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 891968005863 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 891968005864 tetramer interface [polypeptide binding]; other site 891968005865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968005866 catalytic residue [active] 891968005867 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 891968005868 lipoyl attachment site [posttranslational modification]; other site 891968005869 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 891968005870 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 891968005871 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 891968005872 V-type ATP synthase subunit B; Provisional; Region: PRK04196 891968005873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968005874 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 891968005875 Walker A motif homologous position; other site 891968005876 Walker B motif; other site 891968005877 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968005878 V-type ATP synthase subunit A; Provisional; Region: PRK04192 891968005879 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 891968005880 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 891968005881 Walker A motif/ATP binding site; other site 891968005882 Walker B motif; other site 891968005883 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 891968005884 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 891968005885 V-type ATP synthase subunit I; Validated; Region: PRK05771 891968005886 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 891968005887 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 891968005888 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 891968005889 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 891968005890 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 891968005891 active site 891968005892 substrate binding site [chemical binding]; other site 891968005893 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 891968005894 FMN binding site [chemical binding]; other site 891968005895 putative catalytic residues [active] 891968005896 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 891968005897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968005898 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 891968005899 active site 891968005900 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 891968005901 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 891968005902 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 891968005903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 891968005904 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 891968005905 hydroxyglutarate oxidase; Provisional; Region: PRK11728 891968005906 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 891968005907 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 891968005908 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 891968005909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 891968005910 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 891968005911 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 891968005912 Na2 binding site [ion binding]; other site 891968005913 putative substrate binding site 1 [chemical binding]; other site 891968005914 Na binding site 1 [ion binding]; other site 891968005915 putative substrate binding site 2 [chemical binding]; other site 891968005916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 891968005917 Transposase; Region: DDE_Tnp_ISL3; pfam01610 891968005918 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 891968005919 Na binding site [ion binding]; other site 891968005920 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 891968005921 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 891968005922 Cupin domain; Region: Cupin_2; cl17218 891968005923 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 891968005924 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 891968005925 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 891968005926 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 891968005927 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 891968005928 Na binding site [ion binding]; other site 891968005929 S-layer homology domain; Region: SLH; pfam00395 891968005930 Predicted coiled-coil protein (DUF2205); Region: DUF2205; pfam10224 891968005931 Transposase, Mutator family; Region: Transposase_mut; pfam00872 891968005932 MULE transposase domain; Region: MULE; pfam10551 891968005933 Protein of unknown function (DUF917); Region: DUF917; pfam06032 891968005934 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 891968005935 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 891968005936 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 891968005937 active site 891968005938 Protein of unknown function (DUF917); Region: DUF917; pfam06032 891968005939 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 891968005940 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 891968005941 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 891968005942 Na binding site [ion binding]; other site 891968005943 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 891968005944 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 891968005945 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 891968005946 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 891968005947 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 891968005948 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 891968005949 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 891968005950 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 891968005951 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 891968005952 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 891968005953 Na binding site [ion binding]; other site 891968005954 Protein of unknown function (DUF917); Region: DUF917; pfam06032 891968005955 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 891968005956 Protein of unknown function (DUF917); Region: DUF917; pfam06032 891968005957 dipeptidase PepV; Reviewed; Region: PRK07318 891968005958 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 891968005959 active site 891968005960 metal binding site [ion binding]; metal-binding site 891968005961 proline racemase; Provisional; Region: PRK13969 891968005962 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 891968005963 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 891968005964 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 891968005965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 891968005966 FeS/SAM binding site; other site 891968005967 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 891968005968 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 891968005969 dimer interface [polypeptide binding]; other site 891968005970 active site 891968005971 glycine loop; other site 891968005972 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 891968005973 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 891968005974 oligomer interface [polypeptide binding]; other site 891968005975 metal binding site [ion binding]; metal-binding site 891968005976 metal binding site [ion binding]; metal-binding site 891968005977 Cl binding site [ion binding]; other site 891968005978 aspartate ring; other site 891968005979 basic sphincter; other site 891968005980 putative hydrophobic gate; other site 891968005981 periplasmic entrance; other site 891968005982 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 891968005983 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 891968005984 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 891968005985 Radical SAM superfamily; Region: Radical_SAM; pfam04055 891968005986 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 891968005987 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 891968005988 active site 891968005989 putative substrate binding pocket [chemical binding]; other site 891968005990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968005991 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 891968005992 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 891968005993 catalytic triad [active] 891968005994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 891968005995 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 891968005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968005997 dimer interface [polypeptide binding]; other site 891968005998 conserved gate region; other site 891968005999 putative PBP binding loops; other site 891968006000 ABC-ATPase subunit interface; other site 891968006001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 891968006002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006003 dimer interface [polypeptide binding]; other site 891968006004 conserved gate region; other site 891968006005 ABC-ATPase subunit interface; other site 891968006006 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968006007 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 891968006008 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 891968006009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006010 Walker A/P-loop; other site 891968006011 ATP binding site [chemical binding]; other site 891968006012 Q-loop/lid; other site 891968006013 ABC transporter signature motif; other site 891968006014 Walker B; other site 891968006015 D-loop; other site 891968006016 H-loop/switch region; other site 891968006017 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006018 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 891968006019 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006020 Walker A/P-loop; other site 891968006021 ATP binding site [chemical binding]; other site 891968006022 Q-loop/lid; other site 891968006023 ABC transporter signature motif; other site 891968006024 Walker B; other site 891968006025 D-loop; other site 891968006026 H-loop/switch region; other site 891968006027 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006028 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 891968006029 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 891968006030 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 891968006031 NlpC/P60 family; Region: NLPC_P60; cl17555 891968006032 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 891968006033 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 891968006034 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 891968006035 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 891968006036 TIGR04076 family protein; Region: TIGR04076 891968006037 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 891968006038 4Fe-4S binding domain; Region: Fer4; pfam00037 891968006039 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968006040 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968006041 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 891968006042 DctM-like transporters; Region: DctM; pfam06808 891968006043 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968006044 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 891968006045 Transposase, Mutator family; Region: Transposase_mut; pfam00872 891968006046 MULE transposase domain; Region: MULE; pfam10551 891968006047 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 891968006048 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968006049 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968006050 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 891968006051 substrate binding site [chemical binding]; other site 891968006052 Predicted aconitase [General function prediction only]; Region: COG1679 891968006053 Protein of unknown function (DUF521); Region: DUF521; pfam04412 891968006054 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 891968006055 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968006056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968006057 DNA-binding site [nucleotide binding]; DNA binding site 891968006058 FCD domain; Region: FCD; pfam07729 891968006059 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 891968006060 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 891968006061 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 891968006062 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 891968006063 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 891968006064 Prephenate dehydrogenase; Region: PDH; pfam02153 891968006065 prephenate dehydrogenase; Validated; Region: PRK08507 891968006066 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 891968006067 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 891968006068 hinge; other site 891968006069 active site 891968006070 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 891968006071 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 891968006072 Tetramer interface [polypeptide binding]; other site 891968006073 active site 891968006074 FMN-binding site [chemical binding]; other site 891968006075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 891968006076 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 891968006077 ADP binding site [chemical binding]; other site 891968006078 magnesium binding site [ion binding]; other site 891968006079 putative shikimate binding site; other site 891968006080 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 891968006081 active site 891968006082 dimer interface [polypeptide binding]; other site 891968006083 metal binding site [ion binding]; metal-binding site 891968006084 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 891968006085 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 891968006086 Prephenate dehydratase; Region: PDT; pfam00800 891968006087 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 891968006088 putative L-Phe binding site [chemical binding]; other site 891968006089 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 891968006090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006091 dimer interface [polypeptide binding]; other site 891968006092 conserved gate region; other site 891968006093 putative PBP binding loops; other site 891968006094 ABC-ATPase subunit interface; other site 891968006095 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 891968006096 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 891968006097 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 891968006098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 891968006099 Walker A/P-loop; other site 891968006100 ATP binding site [chemical binding]; other site 891968006101 Q-loop/lid; other site 891968006102 ABC transporter signature motif; other site 891968006103 Walker B; other site 891968006104 D-loop; other site 891968006105 H-loop/switch region; other site 891968006106 TOBE domain; Region: TOBE_2; pfam08402 891968006107 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 891968006108 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 891968006109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006110 dimer interface [polypeptide binding]; other site 891968006111 conserved gate region; other site 891968006112 putative PBP binding loops; other site 891968006113 ABC-ATPase subunit interface; other site 891968006114 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 891968006115 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 891968006116 Walker A motif; other site 891968006117 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 891968006118 4Fe-4S binding domain; Region: Fer4; pfam00037 891968006119 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 891968006120 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 891968006121 Secretin and TonB N terminus short domain; Region: STN; pfam07660 891968006122 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 891968006123 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 891968006124 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 891968006125 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 891968006126 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 891968006127 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 891968006128 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 891968006129 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 891968006130 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 891968006131 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 891968006132 Walker A motif; other site 891968006133 ATP binding site [chemical binding]; other site 891968006134 Walker B motif; other site 891968006135 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 891968006136 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 891968006137 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 891968006138 Walker A motif; other site 891968006139 ATP binding site [chemical binding]; other site 891968006140 Walker B motif; other site 891968006141 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 891968006142 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 891968006143 Walker A/P-loop; other site 891968006144 ATP binding site [chemical binding]; other site 891968006145 Q-loop/lid; other site 891968006146 ABC transporter signature motif; other site 891968006147 Walker B; other site 891968006148 D-loop; other site 891968006149 H-loop/switch region; other site 891968006150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 891968006151 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 891968006152 Walker A/P-loop; other site 891968006153 ATP binding site [chemical binding]; other site 891968006154 Q-loop/lid; other site 891968006155 ABC transporter signature motif; other site 891968006156 Walker B; other site 891968006157 D-loop; other site 891968006158 H-loop/switch region; other site 891968006159 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 891968006160 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968006161 TM-ABC transporter signature motif; other site 891968006162 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968006163 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 891968006164 TM-ABC transporter signature motif; other site 891968006165 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 891968006166 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 891968006167 putative ligand binding site [chemical binding]; other site 891968006168 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 891968006169 PemK-like protein; Region: PemK; pfam02452 891968006170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 891968006171 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 891968006172 FtsX-like permease family; Region: FtsX; pfam02687 891968006173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 891968006174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 891968006175 Walker A/P-loop; other site 891968006176 ATP binding site [chemical binding]; other site 891968006177 Q-loop/lid; other site 891968006178 ABC transporter signature motif; other site 891968006179 Walker B; other site 891968006180 D-loop; other site 891968006181 H-loop/switch region; other site 891968006182 macrolide transporter subunit MacA; Provisional; Region: PRK11578 891968006183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 891968006184 HlyD family secretion protein; Region: HlyD_3; pfam13437 891968006185 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 891968006186 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 891968006187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 891968006188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968006189 homodimer interface [polypeptide binding]; other site 891968006190 catalytic residue [active] 891968006191 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 891968006192 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 891968006193 oligomerization interface [polypeptide binding]; other site 891968006194 active site 891968006195 metal binding site [ion binding]; metal-binding site 891968006196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 891968006197 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 891968006198 Transcriptional regulators [Transcription]; Region: FadR; COG2186 891968006199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 891968006200 DNA-binding site [nucleotide binding]; DNA binding site 891968006201 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 891968006202 DctM-like transporters; Region: DctM; pfam06808 891968006203 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 891968006204 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 891968006205 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 891968006206 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 891968006207 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 891968006208 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 891968006209 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 891968006210 Fumarase C-terminus; Region: Fumerase_C; cl00795 891968006211 fumarate hydratase; Provisional; Region: PRK06246 891968006212 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 891968006213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 891968006214 carboxyltransferase (CT) interaction site; other site 891968006215 biotinylation site [posttranslational modification]; other site 891968006216 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 891968006217 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 891968006218 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 891968006219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 891968006220 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 891968006221 dimer interface [polypeptide binding]; other site 891968006222 substrate binding site [chemical binding]; other site 891968006223 metal binding site [ion binding]; metal-binding site 891968006224 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 891968006225 B12 binding site [chemical binding]; other site 891968006226 cobalt ligand [ion binding]; other site 891968006227 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 891968006228 flagellar operon protein TIGR03826; Region: YvyF 891968006229 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 891968006230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 891968006231 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 891968006232 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 891968006233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968006234 motif II; other site 891968006235 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 891968006236 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 891968006237 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 891968006238 NAD(P) binding site [chemical binding]; other site 891968006239 Putative transcription activator [Transcription]; Region: TenA; COG0819 891968006240 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 891968006241 Fe-S cluster binding site [ion binding]; other site 891968006242 active site 891968006243 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 891968006244 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 891968006245 GIY-YIG motif/motif A; other site 891968006246 putative active site [active] 891968006247 putative metal binding site [ion binding]; other site 891968006248 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968006249 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 891968006250 TM-ABC transporter signature motif; other site 891968006251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 891968006252 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 891968006253 TM-ABC transporter signature motif; other site 891968006254 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 891968006255 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 891968006256 Walker A/P-loop; other site 891968006257 ATP binding site [chemical binding]; other site 891968006258 Q-loop/lid; other site 891968006259 ABC transporter signature motif; other site 891968006260 Walker B; other site 891968006261 D-loop; other site 891968006262 H-loop/switch region; other site 891968006263 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 891968006264 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 891968006265 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 891968006266 putative ligand binding site [chemical binding]; other site 891968006267 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 891968006268 active site 891968006269 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 891968006270 Uncharacterized conserved protein [Function unknown]; Region: COG1739 891968006271 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 891968006272 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 891968006273 nucleotide binding site/active site [active] 891968006274 HIT family signature motif; other site 891968006275 catalytic residue [active] 891968006276 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 891968006277 metal binding site 2 [ion binding]; metal-binding site 891968006278 putative DNA binding helix; other site 891968006279 metal binding site 1 [ion binding]; metal-binding site 891968006280 dimer interface [polypeptide binding]; other site 891968006281 structural Zn2+ binding site [ion binding]; other site 891968006282 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 891968006283 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 891968006284 putative metal binding residues [ion binding]; other site 891968006285 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 891968006286 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 891968006287 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 891968006288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 891968006289 ABC-ATPase subunit interface; other site 891968006290 dimer interface [polypeptide binding]; other site 891968006291 putative PBP binding regions; other site 891968006292 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 891968006293 Predicted permease; Region: DUF318; cl17795 891968006294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 891968006295 dimerization interface [polypeptide binding]; other site 891968006296 putative DNA binding site [nucleotide binding]; other site 891968006297 putative Zn2+ binding site [ion binding]; other site 891968006298 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 891968006299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 891968006300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006301 dimer interface [polypeptide binding]; other site 891968006302 conserved gate region; other site 891968006303 putative PBP binding loops; other site 891968006304 ABC-ATPase subunit interface; other site 891968006305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 891968006306 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 891968006307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006308 dimer interface [polypeptide binding]; other site 891968006309 conserved gate region; other site 891968006310 putative PBP binding loops; other site 891968006311 ABC-ATPase subunit interface; other site 891968006312 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 891968006313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006314 Walker A/P-loop; other site 891968006315 ATP binding site [chemical binding]; other site 891968006316 Q-loop/lid; other site 891968006317 ABC transporter signature motif; other site 891968006318 Walker B; other site 891968006319 D-loop; other site 891968006320 H-loop/switch region; other site 891968006321 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006322 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 891968006323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006324 Walker A/P-loop; other site 891968006325 ATP binding site [chemical binding]; other site 891968006326 Q-loop/lid; other site 891968006327 ABC transporter signature motif; other site 891968006328 Walker B; other site 891968006329 D-loop; other site 891968006330 H-loop/switch region; other site 891968006331 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006332 isoaspartyl dipeptidase; Provisional; Region: PRK10657 891968006333 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 891968006334 active site 891968006335 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968006336 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 891968006337 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 891968006338 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 891968006339 ligand binding site [chemical binding]; other site 891968006340 NAD binding site [chemical binding]; other site 891968006341 dimerization interface [polypeptide binding]; other site 891968006342 catalytic site [active] 891968006343 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 891968006344 putative L-serine binding site [chemical binding]; other site 891968006345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 891968006346 catalytic core [active] 891968006347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 891968006348 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 891968006349 putative NAD(P) binding site [chemical binding]; other site 891968006350 putative active site [active] 891968006351 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 891968006352 ParB-like nuclease domain; Region: ParB; smart00470 891968006353 KorB domain; Region: KorB; pfam08535 891968006354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 891968006355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 891968006356 P-loop; other site 891968006357 Magnesium ion binding site [ion binding]; other site 891968006358 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 891968006359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 891968006360 S-adenosylmethionine binding site [chemical binding]; other site 891968006361 Domain of unknown function (DUF364); Region: DUF364; pfam04016 891968006362 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 891968006363 trimer interface [polypeptide binding]; other site 891968006364 putative Zn binding site [ion binding]; other site 891968006365 Staphylococcal nuclease homologues; Region: SNc; smart00318 891968006366 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 891968006367 Catalytic site; other site 891968006368 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006369 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006370 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006371 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006372 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 891968006373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 891968006374 Beta-Casp domain; Region: Beta-Casp; smart01027 891968006375 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 891968006376 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 891968006377 FMN binding site [chemical binding]; other site 891968006378 dimer interface [polypeptide binding]; other site 891968006379 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 891968006380 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 891968006381 catalytic residues [active] 891968006382 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 891968006383 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 891968006384 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 891968006385 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006386 Walker A/P-loop; other site 891968006387 ATP binding site [chemical binding]; other site 891968006388 Q-loop/lid; other site 891968006389 ABC transporter signature motif; other site 891968006390 Walker B; other site 891968006391 D-loop; other site 891968006392 H-loop/switch region; other site 891968006393 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006394 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 891968006395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 891968006396 Walker A/P-loop; other site 891968006397 ATP binding site [chemical binding]; other site 891968006398 Q-loop/lid; other site 891968006399 ABC transporter signature motif; other site 891968006400 Walker B; other site 891968006401 D-loop; other site 891968006402 H-loop/switch region; other site 891968006403 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 891968006404 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 891968006405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 891968006406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006407 dimer interface [polypeptide binding]; other site 891968006408 conserved gate region; other site 891968006409 putative PBP binding loops; other site 891968006410 ABC-ATPase subunit interface; other site 891968006411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 891968006412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 891968006413 dimer interface [polypeptide binding]; other site 891968006414 conserved gate region; other site 891968006415 putative PBP binding loops; other site 891968006416 ABC-ATPase subunit interface; other site 891968006417 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 891968006418 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 891968006419 Protein of unknown function DUF111; Region: DUF111; pfam01969 891968006420 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 891968006421 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 891968006422 Ligand Binding Site [chemical binding]; other site 891968006423 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006424 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 891968006425 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 891968006426 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 891968006427 tetramer interface [polypeptide binding]; other site 891968006428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 891968006429 catalytic residue [active] 891968006430 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 891968006431 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 891968006432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 891968006433 Zn2+ binding site [ion binding]; other site 891968006434 Mg2+ binding site [ion binding]; other site 891968006435 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 891968006436 putative dimer interface [polypeptide binding]; other site 891968006437 active site pocket [active] 891968006438 putative cataytic base [active] 891968006439 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 891968006440 homotrimer interface [polypeptide binding]; other site 891968006441 Walker A motif; other site 891968006442 GTP binding site [chemical binding]; other site 891968006443 Walker B motif; other site 891968006444 cobalamin synthase; Reviewed; Region: cobS; PRK00235 891968006445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968006446 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 891968006447 active site 891968006448 motif I; other site 891968006449 motif II; other site 891968006450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 891968006451 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 891968006452 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 891968006453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 891968006454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 891968006455 catalytic residue [active] 891968006456 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 891968006457 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 891968006458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 891968006459 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 891968006460 DHHA1 domain; Region: DHHA1; pfam02272 891968006461 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 891968006462 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 891968006463 active site 891968006464 metal binding site [ion binding]; metal-binding site