-- dump date 20140618_203745 -- class Genbank::misc_feature -- table misc_feature_note -- id note 926569000001 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569000002 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569000003 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 926569000004 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 926569000005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926569000006 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926569000007 PAS fold; Region: PAS_3; pfam08447 926569000008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569000009 putative active site [active] 926569000010 heme pocket [chemical binding]; other site 926569000011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569000012 GAF domain; Region: GAF; pfam01590 926569000013 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569000014 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569000015 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569000016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569000017 Zn2+ binding site [ion binding]; other site 926569000018 Mg2+ binding site [ion binding]; other site 926569000019 ACT domain; Region: ACT_3; pfam10000 926569000020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 926569000021 Family description; Region: ACT_7; pfam13840 926569000022 Predicted transcriptional regulators [Transcription]; Region: COG1725 926569000023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926569000024 DNA-binding site [nucleotide binding]; DNA binding site 926569000025 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926569000026 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 926569000027 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 926569000028 Predicted integral membrane protein [Function unknown]; Region: COG5658 926569000029 SdpI/YhfL protein family; Region: SdpI; pfam13630 926569000030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926569000031 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926569000032 Walker A/P-loop; other site 926569000033 ATP binding site [chemical binding]; other site 926569000034 Q-loop/lid; other site 926569000035 ABC transporter signature motif; other site 926569000036 Walker B; other site 926569000037 D-loop; other site 926569000038 H-loop/switch region; other site 926569000039 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 926569000040 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926569000041 Rrf2 family protein; Region: rrf2_super; TIGR00738 926569000042 Transcriptional regulator; Region: Rrf2; pfam02082 926569000043 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 926569000044 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926569000045 minor groove reading motif; other site 926569000046 helix-hairpin-helix signature motif; other site 926569000047 substrate binding pocket [chemical binding]; other site 926569000048 active site 926569000049 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 926569000050 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 926569000051 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 926569000052 N- and C-terminal domain interface [polypeptide binding]; other site 926569000053 active site 926569000054 catalytic site [active] 926569000055 metal binding site [ion binding]; metal-binding site 926569000056 carbohydrate binding site [chemical binding]; other site 926569000057 ATP binding site [chemical binding]; other site 926569000058 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 926569000059 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 926569000060 RloB-like protein; Region: RloB; pfam13707 926569000061 AAA domain; Region: AAA_21; pfam13304 926569000062 Cytochrome c552; Region: Cytochrom_C552; pfam02335 926569000063 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 926569000064 phenylhydantoinase; Validated; Region: PRK08323 926569000065 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 926569000066 tetramer interface [polypeptide binding]; other site 926569000067 active site 926569000068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 926569000069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569000070 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569000071 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 926569000072 S-formylglutathione hydrolase; Region: PLN02442 926569000073 Putative esterase; Region: Esterase; pfam00756 926569000074 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 926569000075 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 926569000076 Double zinc ribbon; Region: DZR; pfam12773 926569000077 MutL protein; Region: MutL; pfam13941 926569000078 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926569000079 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 926569000080 DXD motif; other site 926569000081 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569000082 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926569000083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569000084 S-adenosylmethionine binding site [chemical binding]; other site 926569000085 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 926569000086 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926569000087 active site 926569000088 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926569000089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569000090 S-adenosylmethionine binding site [chemical binding]; other site 926569000091 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 926569000092 MgtC family; Region: MgtC; pfam02308 926569000093 HerA helicase [Replication, recombination, and repair]; Region: COG0433 926569000094 HAS barrel domain; Region: HAS-barrel; pfam09378 926569000095 Domain of unknown function DUF87; Region: DUF87; pfam01935 926569000096 PUCC protein; Region: PUCC; pfam03209 926569000097 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 926569000098 ATP-NAD kinase; Region: NAD_kinase; pfam01513 926569000099 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 926569000100 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926569000101 Walker A/P-loop; other site 926569000102 ATP binding site [chemical binding]; other site 926569000103 Q-loop/lid; other site 926569000104 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926569000105 ABC transporter signature motif; other site 926569000106 Walker B; other site 926569000107 D-loop; other site 926569000108 H-loop/switch region; other site 926569000109 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 926569000110 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 926569000111 DNA binding site [nucleotide binding] 926569000112 Predicted ATPase [General function prediction only]; Region: COG3899 926569000113 AAA ATPase domain; Region: AAA_16; pfam13191 926569000114 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569000115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926569000116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569000117 Coenzyme A binding pocket [chemical binding]; other site 926569000118 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 926569000119 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926569000120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569000121 S-adenosylmethionine binding site [chemical binding]; other site 926569000122 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 926569000123 23S rRNA binding site [nucleotide binding]; other site 926569000124 L21 binding site [polypeptide binding]; other site 926569000125 L13 binding site [polypeptide binding]; other site 926569000126 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 926569000127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569000128 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926569000129 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 926569000130 putative catalytic site [active] 926569000131 putative metal binding site [ion binding]; other site 926569000132 putative phosphate binding site [ion binding]; other site 926569000133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569000134 active site 926569000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 926569000136 GIY-YIG motif/motif A; other site 926569000137 putative active site [active] 926569000138 putative metal binding site [ion binding]; other site 926569000139 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 926569000140 prephenate dehydrogenase; Validated; Region: PRK08507 926569000141 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 926569000142 Peptidase family M50; Region: Peptidase_M50; pfam02163 926569000143 active site 926569000144 putative substrate binding region [chemical binding]; other site 926569000145 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 926569000146 monogalactosyldiacylglycerol synthase; Region: PLN02605 926569000147 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 926569000148 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569000149 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926569000150 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 926569000151 dimer interface [polypeptide binding]; other site 926569000152 decamer (pentamer of dimers) interface [polypeptide binding]; other site 926569000153 catalytic triad [active] 926569000154 peroxidatic and resolving cysteines [active] 926569000155 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 926569000156 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 926569000157 putative substrate binding site 1 [chemical binding]; other site 926569000158 Na binding site 1 [ion binding]; other site 926569000159 putative substrate binding site 2 [chemical binding]; other site 926569000160 Na2 binding site [ion binding]; other site 926569000161 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 926569000162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569000163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569000164 DNA binding residues [nucleotide binding] 926569000165 MG2 domain; Region: A2M_N; pfam01835 926569000166 MG2 domain; Region: A2M_N; pfam01835 926569000167 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 926569000168 Alpha-2-macroglobulin family; Region: A2M; pfam00207 926569000169 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 926569000170 surface patch; other site 926569000171 thioester region; other site 926569000172 A-macroglobulin complement component; Region: A2M_comp; pfam07678 926569000173 specificity defining residues; other site 926569000174 A-macroglobulin receptor; Region: A2M_recep; pfam07677 926569000175 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926569000176 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926569000177 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926569000178 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 926569000179 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 926569000180 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 926569000181 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 926569000182 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 926569000183 DXD motif; other site 926569000184 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926569000185 Two component regulator propeller; Region: Reg_prop; pfam07494 926569000186 Two component regulator propeller; Region: Reg_prop; pfam07494 926569000187 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926569000188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569000189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569000190 metal binding site [ion binding]; metal-binding site 926569000191 active site 926569000192 I-site; other site 926569000193 Yip1 domain; Region: Yip1; cl17815 926569000194 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 926569000195 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569000196 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569000197 Walker A/P-loop; other site 926569000198 ATP binding site [chemical binding]; other site 926569000199 Q-loop/lid; other site 926569000200 ABC transporter signature motif; other site 926569000201 Walker B; other site 926569000202 D-loop; other site 926569000203 H-loop/switch region; other site 926569000204 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569000205 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569000206 Walker A/P-loop; other site 926569000207 ATP binding site [chemical binding]; other site 926569000208 Q-loop/lid; other site 926569000209 ABC transporter signature motif; other site 926569000210 Walker B; other site 926569000211 D-loop; other site 926569000212 H-loop/switch region; other site 926569000213 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 926569000214 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 926569000215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569000216 catalytic residue [active] 926569000217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000218 binding surface 926569000219 TPR repeat; Region: TPR_11; pfam13414 926569000220 TPR motif; other site 926569000221 TPR repeat; Region: TPR_11; pfam13414 926569000222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000223 TPR motif; other site 926569000224 binding surface 926569000225 TPR repeat; Region: TPR_11; pfam13414 926569000226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000227 TPR repeat; Region: TPR_11; pfam13414 926569000228 TPR motif; other site 926569000229 binding surface 926569000230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000231 binding surface 926569000232 TPR motif; other site 926569000233 TPR repeat; Region: TPR_11; pfam13414 926569000234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000235 TPR motif; other site 926569000236 binding surface 926569000237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569000238 TPR motif; other site 926569000239 binding surface 926569000240 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926569000241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926569000242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926569000243 ABC transporter; Region: ABC_tran_2; pfam12848 926569000244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926569000245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569000246 recombination factor protein RarA; Reviewed; Region: PRK13342 926569000247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569000248 Walker A motif; other site 926569000249 ATP binding site [chemical binding]; other site 926569000250 Walker B motif; other site 926569000251 arginine finger; other site 926569000252 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 926569000253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569000254 catalytic core [active] 926569000255 PAS domain; Region: PAS_9; pfam13426 926569000256 PAS domain; Region: PAS_9; pfam13426 926569000257 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569000258 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569000259 metal binding site [ion binding]; metal-binding site 926569000260 active site 926569000261 I-site; other site 926569000262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926569000263 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569000264 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569000265 DNA repair protein RadA; Provisional; Region: PRK11823 926569000266 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 926569000267 Walker A motif/ATP binding site; other site 926569000268 ATP binding site [chemical binding]; other site 926569000269 Walker B motif; other site 926569000270 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926569000271 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 926569000272 Ligand binding site; other site 926569000273 Ligand binding site; other site 926569000274 Ligand binding site; other site 926569000275 Putative Catalytic site; other site 926569000276 DXD motif; other site 926569000277 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 926569000278 RNA/DNA hybrid binding site [nucleotide binding]; other site 926569000279 active site 926569000280 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 926569000281 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569000282 Flavodoxin domain; Region: Flavodoxin_5; cl17428 926569000283 B-Box C-terminal domain; Region: BBC; smart00502 926569000284 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 926569000285 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 926569000286 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 926569000287 B12 binding site [chemical binding]; other site 926569000288 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569000289 Rdx family; Region: Rdx; pfam10262 926569000290 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 926569000291 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 926569000292 active site 926569000293 HIGH motif; other site 926569000294 dimer interface [polypeptide binding]; other site 926569000295 KMSKS motif; other site 926569000296 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 926569000297 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926569000298 active site 926569000299 HIGH motif; other site 926569000300 nucleotide binding site [chemical binding]; other site 926569000301 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 926569000302 KMSKS motif; other site 926569000303 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 926569000304 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 926569000305 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 926569000306 HlyD family secretion protein; Region: HlyD_3; pfam13437 926569000307 FtsX-like permease family; Region: FtsX; pfam02687 926569000308 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926569000309 FtsX-like permease family; Region: FtsX; pfam02687 926569000310 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569000311 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569000312 Walker A/P-loop; other site 926569000313 ATP binding site [chemical binding]; other site 926569000314 Q-loop/lid; other site 926569000315 ABC transporter signature motif; other site 926569000316 Walker B; other site 926569000317 D-loop; other site 926569000318 H-loop/switch region; other site 926569000319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569000320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569000321 Walker A/P-loop; other site 926569000322 ATP binding site [chemical binding]; other site 926569000323 Q-loop/lid; other site 926569000324 ABC transporter signature motif; other site 926569000325 Walker B; other site 926569000326 D-loop; other site 926569000327 H-loop/switch region; other site 926569000328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926569000329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926569000330 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 926569000331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569000332 PAS domain; Region: PAS_9; pfam13426 926569000333 putative active site [active] 926569000334 heme pocket [chemical binding]; other site 926569000335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569000336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569000337 metal binding site [ion binding]; metal-binding site 926569000338 active site 926569000339 I-site; other site 926569000340 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 926569000341 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 926569000342 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 926569000343 active site 926569000344 dimer interface [polypeptide binding]; other site 926569000345 motif 1; other site 926569000346 motif 2; other site 926569000347 motif 3; other site 926569000348 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 926569000349 anticodon binding site; other site 926569000350 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 926569000351 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 926569000352 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 926569000353 active site 926569000354 putative substrate binding pocket [chemical binding]; other site 926569000355 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 926569000356 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926569000357 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 926569000358 active site 926569000359 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 926569000360 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 926569000361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926569000362 DNA-binding site [nucleotide binding]; DNA binding site 926569000363 UTRA domain; Region: UTRA; pfam07702 926569000364 peptidase; Reviewed; Region: PRK13004 926569000365 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 926569000366 putative metal binding site [ion binding]; other site 926569000367 putative dimer interface [polypeptide binding]; other site 926569000368 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 926569000369 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926569000370 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926569000371 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 926569000372 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 926569000373 putative substrate binding site [chemical binding]; other site 926569000374 nucleotide binding site [chemical binding]; other site 926569000375 nucleotide binding site [chemical binding]; other site 926569000376 homodimer interface [polypeptide binding]; other site 926569000377 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 926569000378 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 926569000379 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569000380 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569000381 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926569000382 H+ Antiporter protein; Region: 2A0121; TIGR00900 926569000383 YacP-like NYN domain; Region: NYN_YacP; cl01491 926569000384 Lamin Tail Domain; Region: LTD; pfam00932 926569000385 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 926569000386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569000387 Walker A motif; other site 926569000388 ATP binding site [chemical binding]; other site 926569000389 Walker B motif; other site 926569000390 arginine finger; other site 926569000391 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 926569000392 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 926569000393 recombination protein RecR; Reviewed; Region: recR; PRK00076 926569000394 RecR protein; Region: RecR; pfam02132 926569000395 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 926569000396 putative active site [active] 926569000397 putative metal-binding site [ion binding]; other site 926569000398 tetramer interface [polypeptide binding]; other site 926569000399 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926569000400 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 926569000401 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 926569000402 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 926569000403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926569000404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000405 dimer interface [polypeptide binding]; other site 926569000406 conserved gate region; other site 926569000407 putative PBP binding loops; other site 926569000408 ABC-ATPase subunit interface; other site 926569000409 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 926569000410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 926569000411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000412 dimer interface [polypeptide binding]; other site 926569000413 conserved gate region; other site 926569000414 putative PBP binding loops; other site 926569000415 ABC-ATPase subunit interface; other site 926569000416 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 926569000417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569000418 Walker A/P-loop; other site 926569000419 ATP binding site [chemical binding]; other site 926569000420 Q-loop/lid; other site 926569000421 ABC transporter signature motif; other site 926569000422 Walker B; other site 926569000423 D-loop; other site 926569000424 H-loop/switch region; other site 926569000425 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569000426 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 926569000427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569000428 Walker A/P-loop; other site 926569000429 ATP binding site [chemical binding]; other site 926569000430 Q-loop/lid; other site 926569000431 ABC transporter signature motif; other site 926569000432 Walker B; other site 926569000433 D-loop; other site 926569000434 H-loop/switch region; other site 926569000435 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569000436 Response regulator receiver domain; Region: Response_reg; pfam00072 926569000437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569000438 active site 926569000439 phosphorylation site [posttranslational modification] 926569000440 intermolecular recognition site; other site 926569000441 dimerization interface [polypeptide binding]; other site 926569000442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 926569000443 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 926569000444 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 926569000445 D-mannonate oxidoreductase; Provisional; Region: PRK08277 926569000446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569000447 NAD(P) binding site [chemical binding]; other site 926569000448 active site 926569000449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569000450 active site 926569000451 GTPase Era; Reviewed; Region: era; PRK00089 926569000452 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 926569000453 G1 box; other site 926569000454 GTP/Mg2+ binding site [chemical binding]; other site 926569000455 Switch I region; other site 926569000456 G2 box; other site 926569000457 Switch II region; other site 926569000458 G3 box; other site 926569000459 G4 box; other site 926569000460 G5 box; other site 926569000461 KH domain; Region: KH_2; pfam07650 926569000462 YhhN-like protein; Region: YhhN; pfam07947 926569000463 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926569000464 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926569000465 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926569000466 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926569000467 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926569000468 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926569000469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569000470 putative Zn2+ binding site [ion binding]; other site 926569000471 putative DNA binding site [nucleotide binding]; other site 926569000472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569000473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569000474 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569000475 Walker A/P-loop; other site 926569000476 ATP binding site [chemical binding]; other site 926569000477 Q-loop/lid; other site 926569000478 ABC transporter signature motif; other site 926569000479 Walker B; other site 926569000480 D-loop; other site 926569000481 H-loop/switch region; other site 926569000482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569000483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569000484 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 926569000485 Walker A/P-loop; other site 926569000486 ATP binding site [chemical binding]; other site 926569000487 Q-loop/lid; other site 926569000488 ABC transporter signature motif; other site 926569000489 Walker B; other site 926569000490 D-loop; other site 926569000491 H-loop/switch region; other site 926569000492 recombinase A; Provisional; Region: recA; PRK09354 926569000493 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 926569000494 hexamer interface [polypeptide binding]; other site 926569000495 Walker A motif; other site 926569000496 ATP binding site [chemical binding]; other site 926569000497 Walker B motif; other site 926569000498 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 926569000499 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 926569000500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569000501 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 926569000502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569000503 motif II; other site 926569000504 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 926569000505 Thioredoxin; Region: Thioredoxin_4; cl17273 926569000506 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926569000507 active site 926569000508 Integral membrane protein TerC family; Region: TerC; cl10468 926569000509 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 926569000510 Ferritin-like domain; Region: Ferritin; pfam00210 926569000511 ferroxidase diiron center [ion binding]; other site 926569000512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569000513 S-adenosylmethionine binding site [chemical binding]; other site 926569000514 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 926569000515 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 926569000516 active site 926569000517 multimer interface [polypeptide binding]; other site 926569000518 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 926569000519 predicted active site [active] 926569000520 catalytic triad [active] 926569000521 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 926569000522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569000523 Walker A motif; other site 926569000524 ATP binding site [chemical binding]; other site 926569000525 Walker B motif; other site 926569000526 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 926569000527 RxxxH motif; other site 926569000528 thymidylate kinase; Validated; Region: tmk; PRK00698 926569000529 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 926569000530 TMP-binding site; other site 926569000531 ATP-binding site [chemical binding]; other site 926569000532 CHASE4 domain; Region: CHASE4; pfam05228 926569000533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569000534 dimerization interface [polypeptide binding]; other site 926569000535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569000536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569000537 metal binding site [ion binding]; metal-binding site 926569000538 active site 926569000539 I-site; other site 926569000540 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 926569000541 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 926569000542 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 926569000543 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 926569000544 putative ADP-binding pocket [chemical binding]; other site 926569000545 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926569000546 HAMP domain; Region: HAMP; pfam00672 926569000547 dimerization interface [polypeptide binding]; other site 926569000548 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569000549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569000550 putative active site [active] 926569000551 heme pocket [chemical binding]; other site 926569000552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569000553 dimer interface [polypeptide binding]; other site 926569000554 phosphorylation site [posttranslational modification] 926569000555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569000556 ATP binding site [chemical binding]; other site 926569000557 Mg2+ binding site [ion binding]; other site 926569000558 G-X-G motif; other site 926569000559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569000560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569000561 active site 926569000562 phosphorylation site [posttranslational modification] 926569000563 intermolecular recognition site; other site 926569000564 dimerization interface [polypeptide binding]; other site 926569000565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569000566 DNA binding site [nucleotide binding] 926569000567 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926569000568 putative glycosyl transferase; Provisional; Region: PRK10307 926569000569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569000570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569000571 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926569000572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000573 putative PBP binding loops; other site 926569000574 dimer interface [polypeptide binding]; other site 926569000575 ABC-ATPase subunit interface; other site 926569000576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569000577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000578 dimer interface [polypeptide binding]; other site 926569000579 conserved gate region; other site 926569000580 putative PBP binding loops; other site 926569000581 ABC-ATPase subunit interface; other site 926569000582 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569000583 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569000584 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569000585 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 926569000586 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 926569000587 active site 926569000588 PHP Thumb interface [polypeptide binding]; other site 926569000589 metal binding site [ion binding]; metal-binding site 926569000590 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 926569000591 generic binding surface I; other site 926569000592 generic binding surface II; other site 926569000593 6-phosphofructokinase; Provisional; Region: PRK03202 926569000594 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926569000595 active site 926569000596 ADP/pyrophosphate binding site [chemical binding]; other site 926569000597 dimerization interface [polypeptide binding]; other site 926569000598 allosteric effector site; other site 926569000599 fructose-1,6-bisphosphate binding site; other site 926569000600 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 926569000601 homotrimer interaction site [polypeptide binding]; other site 926569000602 active site 926569000603 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 926569000604 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 926569000605 prephenate dehydrogenase; Validated; Region: PRK08507 926569000606 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 926569000607 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 926569000608 hinge; other site 926569000609 active site 926569000610 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 926569000611 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 926569000612 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 926569000613 shikimate binding site; other site 926569000614 NAD(P) binding site [chemical binding]; other site 926569000615 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 926569000616 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 926569000617 Tetramer interface [polypeptide binding]; other site 926569000618 active site 926569000619 FMN-binding site [chemical binding]; other site 926569000620 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 926569000621 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 926569000622 ADP binding site [chemical binding]; other site 926569000623 magnesium binding site [ion binding]; other site 926569000624 putative shikimate binding site; other site 926569000625 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 926569000626 active site 926569000627 dimer interface [polypeptide binding]; other site 926569000628 metal binding site [ion binding]; metal-binding site 926569000629 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 926569000630 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 926569000631 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 926569000632 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 926569000633 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926569000634 Protein of unknown function DUF72; Region: DUF72; pfam01904 926569000635 Coenzyme A transferase; Region: CoA_trans; cl17247 926569000636 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 926569000637 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 926569000638 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 926569000639 Glutamate binding site [chemical binding]; other site 926569000640 homodimer interface [polypeptide binding]; other site 926569000641 NAD binding site [chemical binding]; other site 926569000642 catalytic residues [active] 926569000643 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 926569000644 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 926569000645 putative active site [active] 926569000646 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 926569000647 GAF domain; Region: GAF; cl17456 926569000648 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569000649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569000650 Zn2+ binding site [ion binding]; other site 926569000651 Mg2+ binding site [ion binding]; other site 926569000652 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 926569000653 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569000654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569000655 Walker A/P-loop; other site 926569000656 ATP binding site [chemical binding]; other site 926569000657 Q-loop/lid; other site 926569000658 ABC transporter signature motif; other site 926569000659 Walker B; other site 926569000660 D-loop; other site 926569000661 H-loop/switch region; other site 926569000662 FtsX-like permease family; Region: FtsX; pfam02687 926569000663 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 926569000664 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 926569000665 RNA binding site [nucleotide binding]; other site 926569000666 active site 926569000667 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 926569000668 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 926569000669 DHH family; Region: DHH; pfam01368 926569000670 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 926569000671 translation initiation factor IF-2; Region: IF-2; TIGR00487 926569000672 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 926569000673 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 926569000674 G1 box; other site 926569000675 putative GEF interaction site [polypeptide binding]; other site 926569000676 GTP/Mg2+ binding site [chemical binding]; other site 926569000677 Switch I region; other site 926569000678 G2 box; other site 926569000679 G3 box; other site 926569000680 Switch II region; other site 926569000681 G4 box; other site 926569000682 G5 box; other site 926569000683 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 926569000684 Translation-initiation factor 2; Region: IF-2; pfam11987 926569000685 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 926569000686 Protein of unknown function (DUF448); Region: DUF448; pfam04296 926569000687 putative RNA binding cleft [nucleotide binding]; other site 926569000688 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 926569000689 NusA N-terminal domain; Region: NusA_N; pfam08529 926569000690 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 926569000691 RNA binding site [nucleotide binding]; other site 926569000692 homodimer interface [polypeptide binding]; other site 926569000693 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 926569000694 G-X-X-G motif; other site 926569000695 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 926569000696 G-X-X-G motif; other site 926569000697 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569000698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926569000699 active site 926569000700 ABC-2 type transporter; Region: ABC2_membrane; cl17235 926569000701 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926569000702 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926569000703 ABC-2 type transporter; Region: ABC2_membrane; cl17235 926569000704 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 926569000705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569000706 Walker A/P-loop; other site 926569000707 ATP binding site [chemical binding]; other site 926569000708 Q-loop/lid; other site 926569000709 ABC transporter signature motif; other site 926569000710 Walker B; other site 926569000711 D-loop; other site 926569000712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569000713 H-loop/switch region; other site 926569000714 short chain dehydrogenase; Provisional; Region: PRK06181 926569000715 classical (c) SDRs; Region: SDR_c; cd05233 926569000716 NAD(P) binding site [chemical binding]; other site 926569000717 active site 926569000718 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 926569000719 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 926569000720 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 926569000721 homodimer interface [polypeptide binding]; other site 926569000722 NADP binding site [chemical binding]; other site 926569000723 substrate binding site [chemical binding]; other site 926569000724 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926569000725 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 926569000726 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926569000727 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926569000728 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 926569000729 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 926569000730 active site 926569000731 homodimer interface [polypeptide binding]; other site 926569000732 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569000733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569000734 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569000735 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569000736 TM-ABC transporter signature motif; other site 926569000737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569000738 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569000739 TM-ABC transporter signature motif; other site 926569000740 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 926569000741 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569000742 Walker A/P-loop; other site 926569000743 ATP binding site [chemical binding]; other site 926569000744 Q-loop/lid; other site 926569000745 ABC transporter signature motif; other site 926569000746 Walker B; other site 926569000747 D-loop; other site 926569000748 H-loop/switch region; other site 926569000749 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569000750 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 926569000751 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926569000752 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 926569000753 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 926569000754 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 926569000755 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 926569000756 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926569000757 Catalytic site [active] 926569000758 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 926569000759 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 926569000760 Walker A/P-loop; other site 926569000761 ATP binding site [chemical binding]; other site 926569000762 Q-loop/lid; other site 926569000763 ABC transporter signature motif; other site 926569000764 Walker B; other site 926569000765 D-loop; other site 926569000766 H-loop/switch region; other site 926569000767 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 926569000768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926569000769 ABC-ATPase subunit interface; other site 926569000770 dimer interface [polypeptide binding]; other site 926569000771 putative PBP binding regions; other site 926569000772 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 926569000773 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 926569000774 cobalamin binding residues [chemical binding]; other site 926569000775 putative BtuC binding residues; other site 926569000776 dimer interface [polypeptide binding]; other site 926569000777 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 926569000778 DNA polymerase III subunit delta'; Validated; Region: PRK08485 926569000779 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 926569000780 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926569000781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569000782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569000783 DNA binding residues [nucleotide binding] 926569000784 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 926569000785 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926569000786 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926569000787 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926569000788 MarR family; Region: MarR_2; cl17246 926569000789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569000790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569000791 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569000792 Walker A/P-loop; other site 926569000793 ATP binding site [chemical binding]; other site 926569000794 Q-loop/lid; other site 926569000795 ABC transporter signature motif; other site 926569000796 Walker B; other site 926569000797 D-loop; other site 926569000798 H-loop/switch region; other site 926569000799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569000800 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 926569000801 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569000802 Walker A/P-loop; other site 926569000803 ATP binding site [chemical binding]; other site 926569000804 Q-loop/lid; other site 926569000805 ABC transporter signature motif; other site 926569000806 Walker B; other site 926569000807 D-loop; other site 926569000808 H-loop/switch region; other site 926569000809 PBP superfamily domain; Region: PBP_like_2; cl17296 926569000810 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 926569000811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000812 dimer interface [polypeptide binding]; other site 926569000813 conserved gate region; other site 926569000814 putative PBP binding loops; other site 926569000815 ABC-ATPase subunit interface; other site 926569000816 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 926569000817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569000818 ABC-ATPase subunit interface; other site 926569000819 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 926569000820 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 926569000821 Walker A/P-loop; other site 926569000822 ATP binding site [chemical binding]; other site 926569000823 Q-loop/lid; other site 926569000824 ABC transporter signature motif; other site 926569000825 Walker B; other site 926569000826 D-loop; other site 926569000827 H-loop/switch region; other site 926569000828 Nitrogen regulatory protein P-II; Region: P-II; cl00412 926569000829 Nitrogen regulatory protein P-II; Region: P-II; smart00938 926569000830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 926569000831 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 926569000832 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 926569000833 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926569000834 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 926569000835 dimer interface [polypeptide binding]; other site 926569000836 substrate binding site [chemical binding]; other site 926569000837 metal binding site [ion binding]; metal-binding site 926569000838 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 926569000839 PAS fold; Region: PAS_4; pfam08448 926569000840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569000841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569000842 metal binding site [ion binding]; metal-binding site 926569000843 active site 926569000844 I-site; other site 926569000845 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 926569000846 catalytic residues [active] 926569000847 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 926569000848 oligomerisation interface [polypeptide binding]; other site 926569000849 mobile loop; other site 926569000850 roof hairpin; other site 926569000851 Staphylococcal nuclease homologues; Region: SNc; smart00318 926569000852 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 926569000853 Catalytic site; other site 926569000854 Excalibur calcium-binding domain; Region: Excalibur; cl05460 926569000855 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 926569000856 active site 926569000857 substrate binding site [chemical binding]; other site 926569000858 ATP binding site [chemical binding]; other site 926569000859 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 926569000860 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 926569000861 Maf-like protein; Region: Maf; pfam02545 926569000862 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 926569000863 active site 926569000864 dimer interface [polypeptide binding]; other site 926569000865 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 926569000866 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 926569000867 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926569000868 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926569000869 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 926569000870 GTPase RsgA; Reviewed; Region: PRK00098 926569000871 RNA binding site [nucleotide binding]; other site 926569000872 homodimer interface [polypeptide binding]; other site 926569000873 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 926569000874 GTPase/Zn-binding domain interface [polypeptide binding]; other site 926569000875 GTP/Mg2+ binding site [chemical binding]; other site 926569000876 G4 box; other site 926569000877 G5 box; other site 926569000878 G1 box; other site 926569000879 Switch I region; other site 926569000880 G2 box; other site 926569000881 G3 box; other site 926569000882 Switch II region; other site 926569000883 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 926569000884 Catalytic site [active] 926569000885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 926569000886 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 926569000887 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 926569000888 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 926569000889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926569000890 Beta-Casp domain; Region: Beta-Casp; smart01027 926569000891 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 926569000892 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 926569000893 catalytic site [active] 926569000894 putative active site [active] 926569000895 putative substrate binding site [chemical binding]; other site 926569000896 HRDC domain; Region: HRDC; pfam00570 926569000897 HRDC domain; Region: HRDC; cl02578 926569000898 Uncharacterized conserved protein [Function unknown]; Region: COG3339 926569000899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569000900 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 926569000901 FeS/SAM binding site; other site 926569000902 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 926569000903 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 926569000904 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 926569000905 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 926569000906 active site 926569000907 Riboflavin kinase; Region: Flavokinase; smart00904 926569000908 Thymidylate synthase complementing protein; Region: Thy1; cl03630 926569000909 Thymidylate synthase complementing protein; Region: Thy1; cl03630 926569000910 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 926569000911 Uncharacterized conserved protein [Function unknown]; Region: COG1284 926569000912 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 926569000913 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 926569000914 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 926569000915 cytosine deaminase; Validated; Region: PRK07572 926569000916 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 926569000917 active site 926569000918 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 926569000919 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569000920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569000921 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 926569000922 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 926569000923 putative ligand binding site [chemical binding]; other site 926569000924 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 926569000925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569000926 Walker A/P-loop; other site 926569000927 ATP binding site [chemical binding]; other site 926569000928 Q-loop/lid; other site 926569000929 ABC transporter signature motif; other site 926569000930 Walker B; other site 926569000931 D-loop; other site 926569000932 H-loop/switch region; other site 926569000933 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569000934 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569000935 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569000936 TM-ABC transporter signature motif; other site 926569000937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569000938 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 926569000939 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569000940 TM-ABC transporter signature motif; other site 926569000941 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926569000942 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569000943 catalytic residues [active] 926569000944 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 926569000945 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 926569000946 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 926569000947 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 926569000948 active site 926569000949 FMN binding site [chemical binding]; other site 926569000950 substrate binding site [chemical binding]; other site 926569000951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 926569000952 4Fe-4S binding domain; Region: Fer4; pfam00037 926569000953 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569000954 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569000955 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 926569000956 putative trimer interface [polypeptide binding]; other site 926569000957 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 926569000958 UbiA prenyltransferase family; Region: UbiA; pfam01040 926569000959 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926569000960 L-asparaginase II; Region: Asparaginase_II; pfam06089 926569000961 hypothetical protein; Validated; Region: PRK07682 926569000962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926569000963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569000964 homodimer interface [polypeptide binding]; other site 926569000965 catalytic residue [active] 926569000966 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 926569000967 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 926569000968 active site 926569000969 Substrate binding site; other site 926569000970 Mg++ binding site; other site 926569000971 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569000972 putative CoA binding site [chemical binding]; other site 926569000973 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 926569000974 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 926569000975 active site 926569000976 Zn binding site [ion binding]; other site 926569000977 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 926569000978 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 926569000979 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 926569000980 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569000981 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 926569000982 putative active site [active] 926569000983 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 926569000984 FMN binding site [chemical binding]; other site 926569000985 dimer interface [polypeptide binding]; other site 926569000986 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 926569000987 6-phosphogluconate dehydratase; Region: edd; TIGR01196 926569000988 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 926569000989 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 926569000990 PYR/PP interface [polypeptide binding]; other site 926569000991 dimer interface [polypeptide binding]; other site 926569000992 TPP binding site [chemical binding]; other site 926569000993 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 926569000994 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 926569000995 TPP-binding site [chemical binding]; other site 926569000996 dimer interface [polypeptide binding]; other site 926569000997 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 926569000998 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 926569000999 putative valine binding site [chemical binding]; other site 926569001000 dimer interface [polypeptide binding]; other site 926569001001 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 926569001002 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 926569001003 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 926569001004 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 926569001005 2-isopropylmalate synthase; Validated; Region: PRK00915 926569001006 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 926569001007 active site 926569001008 catalytic residues [active] 926569001009 metal binding site [ion binding]; metal-binding site 926569001010 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 926569001011 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 926569001012 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 926569001013 substrate binding site [chemical binding]; other site 926569001014 ligand binding site [chemical binding]; other site 926569001015 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 926569001016 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 926569001017 substrate binding site [chemical binding]; other site 926569001018 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 926569001019 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 926569001020 active site 926569001021 catalytic residues [active] 926569001022 metal binding site [ion binding]; metal-binding site 926569001023 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 926569001024 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 926569001025 tartrate dehydrogenase; Region: TTC; TIGR02089 926569001026 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 926569001027 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 926569001028 homodimer interface [polypeptide binding]; other site 926569001029 substrate-cofactor binding pocket; other site 926569001030 catalytic residue [active] 926569001031 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 926569001032 Prephenate dehydratase; Region: PDT; pfam00800 926569001033 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 926569001034 putative L-Phe binding site [chemical binding]; other site 926569001035 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 926569001036 FOG: CBS domain [General function prediction only]; Region: COG0517 926569001037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 926569001038 FOG: CBS domain [General function prediction only]; Region: COG0517 926569001039 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926569001040 FOG: CBS domain [General function prediction only]; Region: COG0517 926569001041 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926569001042 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 926569001043 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 926569001044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569001045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569001046 putative substrate translocation pore; other site 926569001047 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 926569001048 nudix motif; other site 926569001049 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 926569001050 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926569001051 FOG: PKD repeat [General function prediction only]; Region: COG3291 926569001052 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926569001053 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926569001054 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926569001055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926569001056 active site 926569001057 metal binding site [ion binding]; metal-binding site 926569001058 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926569001059 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569001060 catalytic residues [active] 926569001061 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 926569001062 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 926569001063 PAS domain S-box; Region: sensory_box; TIGR00229 926569001064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569001065 putative active site [active] 926569001066 heme pocket [chemical binding]; other site 926569001067 PAS domain S-box; Region: sensory_box; TIGR00229 926569001068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569001069 putative active site [active] 926569001070 heme pocket [chemical binding]; other site 926569001071 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569001072 GAF domain; Region: GAF_2; pfam13185 926569001073 GAF domain; Region: GAF_3; pfam13492 926569001074 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569001075 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569001076 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569001077 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569001078 Zn2+ binding site [ion binding]; other site 926569001079 Mg2+ binding site [ion binding]; other site 926569001080 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 926569001081 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 926569001082 active site 926569001083 Zn binding site [ion binding]; other site 926569001084 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 926569001085 MoaE interaction surface [polypeptide binding]; other site 926569001086 MoeB interaction surface [polypeptide binding]; other site 926569001087 thiocarboxylated glycine; other site 926569001088 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 926569001089 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 926569001090 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 926569001091 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 926569001092 catalytic residue [active] 926569001093 putative FPP diphosphate binding site; other site 926569001094 putative FPP binding hydrophobic cleft; other site 926569001095 dimer interface [polypeptide binding]; other site 926569001096 putative IPP diphosphate binding site; other site 926569001097 ribosome recycling factor; Reviewed; Region: frr; PRK00083 926569001098 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 926569001099 hinge region; other site 926569001100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569001101 dimerization interface [polypeptide binding]; other site 926569001102 putative DNA binding site [nucleotide binding]; other site 926569001103 putative Zn2+ binding site [ion binding]; other site 926569001104 DNA gyrase subunit A; Validated; Region: PRK05560 926569001105 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 926569001106 CAP-like domain; other site 926569001107 active site 926569001108 primary dimer interface [polypeptide binding]; other site 926569001109 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001110 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001114 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569001115 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 926569001116 GTP-binding protein Der; Reviewed; Region: PRK00093 926569001117 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 926569001118 G1 box; other site 926569001119 GTP/Mg2+ binding site [chemical binding]; other site 926569001120 Switch I region; other site 926569001121 G2 box; other site 926569001122 Switch II region; other site 926569001123 G3 box; other site 926569001124 G4 box; other site 926569001125 G5 box; other site 926569001126 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 926569001127 G1 box; other site 926569001128 GTP/Mg2+ binding site [chemical binding]; other site 926569001129 Switch I region; other site 926569001130 G2 box; other site 926569001131 G3 box; other site 926569001132 Switch II region; other site 926569001133 G4 box; other site 926569001134 G5 box; other site 926569001135 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 926569001136 SxDxEG motif; other site 926569001137 active site 926569001138 metal binding site [ion binding]; metal-binding site 926569001139 homopentamer interface [polypeptide binding]; other site 926569001140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569001141 binding surface 926569001142 TPR motif; other site 926569001143 TPR repeat; Region: TPR_11; pfam13414 926569001144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569001145 binding surface 926569001146 TPR motif; other site 926569001147 TPR repeat; Region: TPR_11; pfam13414 926569001148 Transglycosylase; Region: Transgly; cl17702 926569001149 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 926569001150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 926569001151 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 926569001152 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926569001153 aminoglycoside resistance protein; Provisional; Region: PRK13746 926569001154 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 926569001155 active site 926569001156 NTP binding site [chemical binding]; other site 926569001157 metal binding triad [ion binding]; metal-binding site 926569001158 antibiotic binding site [chemical binding]; other site 926569001159 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 926569001160 HAMP domain; Region: HAMP; pfam00672 926569001161 PAS domain S-box; Region: sensory_box; TIGR00229 926569001162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569001163 putative active site [active] 926569001164 heme pocket [chemical binding]; other site 926569001165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569001166 PAS fold; Region: PAS_3; pfam08447 926569001167 putative active site [active] 926569001168 heme pocket [chemical binding]; other site 926569001169 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569001170 GAF domain; Region: GAF_2; pfam13185 926569001171 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569001172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569001173 Zn2+ binding site [ion binding]; other site 926569001174 Mg2+ binding site [ion binding]; other site 926569001175 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 926569001176 active site 926569001177 PAP2 superfamily; Region: PAP2; pfam01569 926569001178 active site 926569001179 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926569001180 CAAX protease self-immunity; Region: Abi; pfam02517 926569001181 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 926569001182 Peptidase family M28; Region: Peptidase_M28; pfam04389 926569001183 metal binding site [ion binding]; metal-binding site 926569001184 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 926569001185 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 926569001186 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 926569001187 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 926569001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001189 dimer interface [polypeptide binding]; other site 926569001190 conserved gate region; other site 926569001191 putative PBP binding loops; other site 926569001192 ABC-ATPase subunit interface; other site 926569001193 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 926569001194 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 926569001195 Walker A/P-loop; other site 926569001196 ATP binding site [chemical binding]; other site 926569001197 Q-loop/lid; other site 926569001198 ABC transporter signature motif; other site 926569001199 Walker B; other site 926569001200 D-loop; other site 926569001201 H-loop/switch region; other site 926569001202 NMT1/THI5 like; Region: NMT1; pfam09084 926569001203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926569001204 membrane-bound complex binding site; other site 926569001205 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 926569001206 V4R domain; Region: V4R; cl15268 926569001207 Response regulator receiver domain; Region: Response_reg; pfam00072 926569001208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569001209 active site 926569001210 phosphorylation site [posttranslational modification] 926569001211 intermolecular recognition site; other site 926569001212 dimerization interface [polypeptide binding]; other site 926569001213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569001214 metal binding site [ion binding]; metal-binding site 926569001215 active site 926569001216 I-site; other site 926569001217 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 926569001218 Ligand binding site; other site 926569001219 Putative Catalytic site; other site 926569001220 DXD motif; other site 926569001221 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 926569001222 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 926569001223 Domain of unknown function (DUF348); Region: DUF348; pfam03990 926569001224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 926569001225 Domain of unknown function (DUF348); Region: DUF348; pfam03990 926569001226 G5 domain; Region: G5; pfam07501 926569001227 Uncharacterized conserved protein [Function unknown]; Region: COG2006 926569001228 Domain of unknown function (DUF362); Region: DUF362; pfam04015 926569001229 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569001230 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 926569001231 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 926569001232 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 926569001233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569001234 non-specific DNA binding site [nucleotide binding]; other site 926569001235 salt bridge; other site 926569001236 sequence-specific DNA binding site [nucleotide binding]; other site 926569001237 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 926569001238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569001239 non-specific DNA binding site [nucleotide binding]; other site 926569001240 salt bridge; other site 926569001241 sequence-specific DNA binding site [nucleotide binding]; other site 926569001242 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 926569001243 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 926569001244 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926569001245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569001246 FeS/SAM binding site; other site 926569001247 TRAM domain; Region: TRAM; pfam01938 926569001248 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926569001249 SnoaL-like domain; Region: SnoaL_2; pfam12680 926569001250 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 926569001251 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 926569001252 dimer interface [polypeptide binding]; other site 926569001253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569001254 catalytic residue [active] 926569001255 serine O-acetyltransferase; Region: cysE; TIGR01172 926569001256 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 926569001257 trimer interface [polypeptide binding]; other site 926569001258 active site 926569001259 substrate binding site [chemical binding]; other site 926569001260 CoA binding site [chemical binding]; other site 926569001261 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 926569001262 isocitrate dehydrogenase; Validated; Region: PRK07362 926569001263 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 926569001264 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 926569001265 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569001266 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926569001267 substrate binding site [chemical binding]; other site 926569001268 ATP binding site [chemical binding]; other site 926569001269 Class I aldolases; Region: Aldolase_Class_I; cl17187 926569001270 catalytic residue [active] 926569001271 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 926569001272 alpha-galactosidase; Provisional; Region: PRK15076 926569001273 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 926569001274 NAD binding site [chemical binding]; other site 926569001275 sugar binding site [chemical binding]; other site 926569001276 divalent metal binding site [ion binding]; other site 926569001277 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569001278 dimer interface [polypeptide binding]; other site 926569001279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569001280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001281 dimer interface [polypeptide binding]; other site 926569001282 conserved gate region; other site 926569001283 putative PBP binding loops; other site 926569001284 ABC-ATPase subunit interface; other site 926569001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001286 dimer interface [polypeptide binding]; other site 926569001287 conserved gate region; other site 926569001288 putative PBP binding loops; other site 926569001289 ABC-ATPase subunit interface; other site 926569001290 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569001291 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569001292 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 926569001293 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926569001294 dimer interface [polypeptide binding]; other site 926569001295 active site 926569001296 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926569001297 dimer interface [polypeptide binding]; other site 926569001298 active site 926569001299 Amidohydrolase; Region: Amidohydro_2; pfam04909 926569001300 active site 926569001301 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 926569001302 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 926569001303 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 926569001304 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 926569001305 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 926569001306 active site 926569001307 HIGH motif; other site 926569001308 KMSKS motif; other site 926569001309 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 926569001310 tRNA binding surface [nucleotide binding]; other site 926569001311 anticodon binding site; other site 926569001312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569001313 binding surface 926569001314 TPR repeat; Region: TPR_11; pfam13414 926569001315 TPR motif; other site 926569001316 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 926569001317 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 926569001318 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 926569001319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569001320 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 926569001321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569001322 DNA binding residues [nucleotide binding] 926569001323 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 926569001324 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 926569001325 active site 926569001326 dimerization interface [polypeptide binding]; other site 926569001327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569001328 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569001329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569001330 Histidine kinase; Region: HisKA_3; pfam07730 926569001331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569001332 ATP binding site [chemical binding]; other site 926569001333 Mg2+ binding site [ion binding]; other site 926569001334 G-X-G motif; other site 926569001335 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 926569001336 Clp amino terminal domain; Region: Clp_N; pfam02861 926569001337 Clp amino terminal domain; Region: Clp_N; pfam02861 926569001338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569001339 Walker A motif; other site 926569001340 ATP binding site [chemical binding]; other site 926569001341 Walker B motif; other site 926569001342 arginine finger; other site 926569001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569001344 Walker A motif; other site 926569001345 ATP binding site [chemical binding]; other site 926569001346 Walker B motif; other site 926569001347 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926569001348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569001349 Coenzyme A binding pocket [chemical binding]; other site 926569001350 Membrane protein of unknown function; Region: DUF360; pfam04020 926569001351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926569001352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569001353 Coenzyme A binding pocket [chemical binding]; other site 926569001354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 926569001355 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 926569001356 Walker A/P-loop; other site 926569001357 ATP binding site [chemical binding]; other site 926569001358 Q-loop/lid; other site 926569001359 ABC transporter signature motif; other site 926569001360 Walker B; other site 926569001361 D-loop; other site 926569001362 H-loop/switch region; other site 926569001363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001364 dimer interface [polypeptide binding]; other site 926569001365 conserved gate region; other site 926569001366 putative PBP binding loops; other site 926569001367 ABC-ATPase subunit interface; other site 926569001368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926569001369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 926569001370 substrate binding pocket [chemical binding]; other site 926569001371 membrane-bound complex binding site; other site 926569001372 hinge residues; other site 926569001373 Proline dehydrogenase; Region: Pro_dh; cl03282 926569001374 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 926569001375 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 926569001376 dimer interface [polypeptide binding]; other site 926569001377 putative functional site; other site 926569001378 putative MPT binding site; other site 926569001379 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926569001380 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 926569001381 putative active site [active] 926569001382 putative metal binding site [ion binding]; other site 926569001383 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 926569001384 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 926569001385 dimer interface [polypeptide binding]; other site 926569001386 putative functional site; other site 926569001387 putative MPT binding site; other site 926569001388 PBP superfamily domain; Region: PBP_like; pfam12727 926569001389 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 926569001390 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569001391 catalytic triad [active] 926569001392 Rrf2 family protein; Region: rrf2_super; TIGR00738 926569001393 Transcriptional regulator; Region: Rrf2; pfam02082 926569001394 Cytochrome c; Region: Cytochrom_C; pfam00034 926569001395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926569001396 Histidine kinase; Region: HisKA_3; pfam07730 926569001397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569001398 ATP binding site [chemical binding]; other site 926569001399 Mg2+ binding site [ion binding]; other site 926569001400 G-X-G motif; other site 926569001401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569001402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569001403 active site 926569001404 phosphorylation site [posttranslational modification] 926569001405 intermolecular recognition site; other site 926569001406 dimerization interface [polypeptide binding]; other site 926569001407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569001408 DNA binding residues [nucleotide binding] 926569001409 dimerization interface [polypeptide binding]; other site 926569001410 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926569001411 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 926569001412 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 926569001413 MPN+ (JAMM) motif; other site 926569001414 Zinc-binding site [ion binding]; other site 926569001415 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 926569001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569001417 ATP binding site [chemical binding]; other site 926569001418 Mg2+ binding site [ion binding]; other site 926569001419 G-X-G motif; other site 926569001420 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 926569001421 anchoring element; other site 926569001422 dimer interface [polypeptide binding]; other site 926569001423 ATP binding site [chemical binding]; other site 926569001424 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 926569001425 active site 926569001426 putative metal-binding site [ion binding]; other site 926569001427 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 926569001428 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569001429 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569001430 ligand binding site [chemical binding]; other site 926569001431 flexible hinge region; other site 926569001432 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926569001433 putative switch regulator; other site 926569001434 non-specific DNA interactions [nucleotide binding]; other site 926569001435 DNA binding site [nucleotide binding] 926569001436 sequence specific DNA binding site [nucleotide binding]; other site 926569001437 putative cAMP binding site [chemical binding]; other site 926569001438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569001439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569001440 putative substrate translocation pore; other site 926569001441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569001442 Coenzyme A binding pocket [chemical binding]; other site 926569001443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926569001444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569001445 Coenzyme A binding pocket [chemical binding]; other site 926569001446 Protein of unknown function (DUF970); Region: DUF970; cl17525 926569001447 Protein of unknown function (DUF970); Region: DUF970; cl17525 926569001448 Nitrogen regulatory protein P-II; Region: P-II; smart00938 926569001449 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 926569001450 AMMECR1; Region: AMMECR1; pfam01871 926569001451 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 926569001452 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 926569001453 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 926569001454 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 926569001455 active site 926569001456 Zn binding site [ion binding]; other site 926569001457 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 926569001458 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 926569001459 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 926569001460 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 926569001461 dimer interface [polypeptide binding]; other site 926569001462 PYR/PP interface [polypeptide binding]; other site 926569001463 TPP binding site [chemical binding]; other site 926569001464 substrate binding site [chemical binding]; other site 926569001465 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 926569001466 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 926569001467 TPP-binding site [chemical binding]; other site 926569001468 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 926569001469 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 926569001470 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 926569001471 Clp amino terminal domain; Region: Clp_N; pfam02861 926569001472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569001473 Walker A motif; other site 926569001474 ATP binding site [chemical binding]; other site 926569001475 Walker B motif; other site 926569001476 arginine finger; other site 926569001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569001478 Walker A motif; other site 926569001479 ATP binding site [chemical binding]; other site 926569001480 Walker B motif; other site 926569001481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926569001482 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 926569001483 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 926569001484 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 926569001485 catalytic triad [active] 926569001486 glutamate racemase; Provisional; Region: PRK00865 926569001487 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 926569001488 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569001489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001490 dimer interface [polypeptide binding]; other site 926569001491 conserved gate region; other site 926569001492 putative PBP binding loops; other site 926569001493 ABC-ATPase subunit interface; other site 926569001494 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926569001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569001496 putative PBP binding loops; other site 926569001497 dimer interface [polypeptide binding]; other site 926569001498 ABC-ATPase subunit interface; other site 926569001499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569001500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569001501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569001502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569001503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569001504 DNA binding site [nucleotide binding] 926569001505 domain linker motif; other site 926569001506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926569001507 dimerization interface [polypeptide binding]; other site 926569001508 ligand binding site [chemical binding]; other site 926569001509 Uncharacterized conserved protein [Function unknown]; Region: COG3743 926569001510 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 926569001511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569001512 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 926569001513 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926569001514 Ligand binding site; other site 926569001515 Putative Catalytic site; other site 926569001516 DXD motif; other site 926569001517 threonine synthase; Validated; Region: PRK06260 926569001518 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 926569001519 homodimer interface [polypeptide binding]; other site 926569001520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569001521 catalytic residue [active] 926569001522 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 926569001523 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569001524 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569001525 TM-ABC transporter signature motif; other site 926569001526 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569001527 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569001528 TM-ABC transporter signature motif; other site 926569001529 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 926569001530 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569001531 Walker A/P-loop; other site 926569001532 ATP binding site [chemical binding]; other site 926569001533 Q-loop/lid; other site 926569001534 ABC transporter signature motif; other site 926569001535 Walker B; other site 926569001536 D-loop; other site 926569001537 H-loop/switch region; other site 926569001538 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569001539 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 926569001540 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 926569001541 putative ligand binding site [chemical binding]; other site 926569001542 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 926569001543 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 926569001544 Uncharacterized conserved protein [Function unknown]; Region: COG2461 926569001545 Family of unknown function (DUF438); Region: DUF438; pfam04282 926569001546 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 926569001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926569001548 binding surface 926569001549 TPR motif; other site 926569001550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569001551 binding surface 926569001552 TPR motif; other site 926569001553 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 926569001554 Bacterial transcriptional activator domain; Region: BTAD; smart01043 926569001555 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 926569001556 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 926569001557 dimer interface [polypeptide binding]; other site 926569001558 ADP-ribose binding site [chemical binding]; other site 926569001559 active site 926569001560 nudix motif; other site 926569001561 metal binding site [ion binding]; metal-binding site 926569001562 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569001563 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569001564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569001565 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 926569001566 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 926569001567 tetramer interface [polypeptide binding]; other site 926569001568 active site 926569001569 Mg2+/Mn2+ binding site [ion binding]; other site 926569001570 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 926569001571 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 926569001572 oxalacetate binding site [chemical binding]; other site 926569001573 citrylCoA binding site [chemical binding]; other site 926569001574 coenzyme A binding site [chemical binding]; other site 926569001575 catalytic triad [active] 926569001576 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 926569001577 2-methylcitrate dehydratase; Region: prpD; TIGR02330 926569001578 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569001579 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569001580 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 926569001581 active site 926569001582 dimer interfaces [polypeptide binding]; other site 926569001583 catalytic residues [active] 926569001584 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 926569001585 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 926569001586 putative homodimer interface [polypeptide binding]; other site 926569001587 putative homotetramer interface [polypeptide binding]; other site 926569001588 putative allosteric switch controlling residues; other site 926569001589 putative metal binding site [ion binding]; other site 926569001590 putative homodimer-homodimer interface [polypeptide binding]; other site 926569001591 OsmC-like protein; Region: OsmC; cl00767 926569001592 threonine synthase; Reviewed; Region: PRK06721 926569001593 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 926569001594 homodimer interface [polypeptide binding]; other site 926569001595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569001596 catalytic residue [active] 926569001597 homoserine kinase; Provisional; Region: PRK01212 926569001598 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 926569001599 UbiA prenyltransferase family; Region: UbiA; pfam01040 926569001600 putative acyltransferase; Provisional; Region: PRK05790 926569001601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926569001602 dimer interface [polypeptide binding]; other site 926569001603 active site 926569001604 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 926569001605 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 926569001606 putative NADP binding site [chemical binding]; other site 926569001607 putative substrate binding site [chemical binding]; other site 926569001608 active site 926569001609 CAAX protease self-immunity; Region: Abi; pfam02517 926569001610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 926569001611 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 926569001612 Homeodomain-like domain; Region: HTH_23; pfam13384 926569001613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 926569001614 ribonuclease Z; Region: RNase_Z; TIGR02651 926569001615 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 926569001616 hypothetical protein; Provisional; Region: PRK04164 926569001617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569001618 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 926569001619 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 926569001620 xylose isomerase; Provisional; Region: PRK12677 926569001621 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926569001622 MarR family; Region: MarR; pfam01047 926569001623 Uncharacterized conserved protein [Function unknown]; Region: COG2353 926569001624 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 926569001625 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926569001626 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926569001627 Peptidase M16C associated; Region: M16C_assoc; pfam08367 926569001628 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 926569001629 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 926569001630 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 926569001631 active site 926569001632 ATP binding site [chemical binding]; other site 926569001633 substrate binding site [chemical binding]; other site 926569001634 activation loop (A-loop); other site 926569001635 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 926569001636 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 926569001637 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926569001638 hypothetical protein; Provisional; Region: PRK08262 926569001639 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 926569001640 metal binding site [ion binding]; metal-binding site 926569001641 Polycystin cation channel protein; Provisional; Region: PLN03223 926569001642 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 926569001643 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 926569001644 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 926569001645 active site 926569001646 catalytic site [active] 926569001647 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 926569001648 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 926569001649 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 926569001650 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926569001651 GIY-YIG motif/motif A; other site 926569001652 active site 926569001653 catalytic site [active] 926569001654 putative DNA binding site [nucleotide binding]; other site 926569001655 metal binding site [ion binding]; metal-binding site 926569001656 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 926569001657 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 926569001658 DNA binding site [nucleotide binding] 926569001659 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 926569001660 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 926569001661 UbiA prenyltransferase family; Region: UbiA; pfam01040 926569001662 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 926569001663 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926569001664 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926569001665 Cu(I) binding site [ion binding]; other site 926569001666 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 926569001667 Subunit I/III interface [polypeptide binding]; other site 926569001668 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 926569001669 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 926569001670 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 926569001671 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 926569001672 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 926569001673 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 926569001674 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926569001675 Cytochrome c; Region: Cytochrom_C; pfam00034 926569001676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569001677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569001678 DNA binding residues [nucleotide binding] 926569001679 dimerization interface [polypeptide binding]; other site 926569001680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926569001681 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926569001682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569001683 S-adenosylmethionine binding site [chemical binding]; other site 926569001684 Histone acetyltransferase [Transcription / Chromatin structure and dynamics]; Region: ELP3; COG1243 926569001685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569001686 FeS/SAM binding site; other site 926569001687 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 926569001688 beta-galactosidase; Region: BGL; TIGR03356 926569001689 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 926569001690 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 926569001691 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 926569001692 metal ion-dependent adhesion site (MIDAS); other site 926569001693 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569001694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569001695 DNA binding site [nucleotide binding] 926569001696 domain linker motif; other site 926569001697 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926569001698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569001699 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 926569001700 substrate binding site [chemical binding]; other site 926569001701 dimer interface [polypeptide binding]; other site 926569001702 ATP binding site [chemical binding]; other site 926569001703 D-ribose pyranase; Provisional; Region: PRK11797 926569001704 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569001705 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569001706 TM-ABC transporter signature motif; other site 926569001707 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 926569001708 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 926569001709 ligand binding site [chemical binding]; other site 926569001710 dimerization interface [polypeptide binding]; other site 926569001711 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 926569001712 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569001713 Walker A/P-loop; other site 926569001714 ATP binding site [chemical binding]; other site 926569001715 Q-loop/lid; other site 926569001716 ABC transporter signature motif; other site 926569001717 Walker B; other site 926569001718 D-loop; other site 926569001719 H-loop/switch region; other site 926569001720 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569001721 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569001722 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569001723 TM-ABC transporter signature motif; other site 926569001724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926569001725 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 926569001726 Walker A/P-loop; other site 926569001727 ATP binding site [chemical binding]; other site 926569001728 Q-loop/lid; other site 926569001729 ABC transporter signature motif; other site 926569001730 Walker B; other site 926569001731 D-loop; other site 926569001732 H-loop/switch region; other site 926569001733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926569001734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569001735 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926569001736 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 926569001737 oligomer interface [polypeptide binding]; other site 926569001738 active site 926569001739 metal binding site [ion binding]; metal-binding site 926569001740 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926569001741 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 926569001742 oligomer interface [polypeptide binding]; other site 926569001743 active site 926569001744 metal binding site [ion binding]; metal-binding site 926569001745 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926569001746 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 926569001747 oligomer interface [polypeptide binding]; other site 926569001748 active site 926569001749 metal binding site [ion binding]; metal-binding site 926569001750 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 926569001751 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 926569001752 adenosine deaminase; Provisional; Region: PRK09358 926569001753 active site 926569001754 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 926569001755 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569001756 structural tetrad; other site 926569001757 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569001758 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569001759 structural tetrad; other site 926569001760 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 926569001761 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 926569001762 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926569001763 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926569001764 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926569001765 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569001766 Ubiquitin-like proteins; Region: UBQ; cl00155 926569001767 charged pocket; other site 926569001768 hydrophobic patch; other site 926569001769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569001770 membrane protein FdrA; Validated; Region: PRK06091 926569001771 CoA binding domain; Region: CoA_binding; cl17356 926569001772 CoA-ligase; Region: Ligase_CoA; pfam00549 926569001773 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 926569001774 Putative cyclase; Region: Cyclase; pfam04199 926569001775 Putative cyclase; Region: Cyclase; pfam04199 926569001776 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 926569001777 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 926569001778 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 926569001779 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569001780 catalytic loop [active] 926569001781 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 926569001782 iron binding site [ion binding]; other site 926569001783 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926569001784 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 926569001785 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569001786 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569001787 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 926569001788 putative hydrophobic ligand binding site [chemical binding]; other site 926569001789 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 926569001790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569001791 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926569001792 NAD(P) binding site [chemical binding]; other site 926569001793 active site 926569001794 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 926569001795 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 926569001796 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 926569001797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569001798 catalytic loop [active] 926569001799 iron binding site [ion binding]; other site 926569001800 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926569001801 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 926569001802 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569001803 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569001804 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 926569001805 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 926569001806 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 926569001807 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 926569001808 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 926569001809 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926569001810 carboxyltransferase (CT) interaction site; other site 926569001811 biotinylation site [posttranslational modification]; other site 926569001812 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 926569001813 Putative cyclase; Region: Cyclase; pfam04199 926569001814 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 926569001815 Response regulator receiver domain; Region: Response_reg; pfam00072 926569001816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569001817 active site 926569001818 phosphorylation site [posttranslational modification] 926569001819 intermolecular recognition site; other site 926569001820 dimerization interface [polypeptide binding]; other site 926569001821 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926569001822 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 926569001823 active site 926569001824 dimerization interface [polypeptide binding]; other site 926569001825 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 926569001826 substrate binding site [chemical binding]; other site 926569001827 active site 926569001828 catalytic residues [active] 926569001829 heterodimer interface [polypeptide binding]; other site 926569001830 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 926569001831 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 926569001832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569001833 catalytic residue [active] 926569001834 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 926569001835 active site 926569001836 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 926569001837 active site 926569001838 ribulose/triose binding site [chemical binding]; other site 926569001839 phosphate binding site [ion binding]; other site 926569001840 substrate (anthranilate) binding pocket [chemical binding]; other site 926569001841 product (indole) binding pocket [chemical binding]; other site 926569001842 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 926569001843 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 926569001844 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 926569001845 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 926569001846 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 926569001847 glutamine binding [chemical binding]; other site 926569001848 catalytic triad [active] 926569001849 anthranilate synthase component I; Provisional; Region: PRK13565 926569001850 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 926569001851 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926569001852 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 926569001853 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 926569001854 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 926569001855 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 926569001856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569001857 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 926569001858 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 926569001859 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 926569001860 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 926569001861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569001862 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 926569001863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926569001864 metal binding site 2 [ion binding]; metal-binding site 926569001865 putative DNA binding helix; other site 926569001866 metal binding site 1 [ion binding]; metal-binding site 926569001867 dimer interface [polypeptide binding]; other site 926569001868 structural Zn2+ binding site [ion binding]; other site 926569001869 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 926569001870 Ferritin-like domain; Region: Ferritin; pfam00210 926569001871 dinuclear metal binding motif [ion binding]; other site 926569001872 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 926569001873 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 926569001874 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 926569001875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926569001876 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 926569001877 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 926569001878 HEPN domain; Region: HEPN; pfam05168 926569001879 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 926569001880 active site 926569001881 NTP binding site [chemical binding]; other site 926569001882 metal binding triad [ion binding]; metal-binding site 926569001883 antibiotic binding site [chemical binding]; other site 926569001884 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926569001885 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569001886 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 926569001887 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926569001888 Ligand binding site; other site 926569001889 Putative Catalytic site; other site 926569001890 DXD motif; other site 926569001891 Transcriptional regulator [Transcription]; Region: LytR; COG1316 926569001892 Trm112p-like protein; Region: Trm112p; cl01066 926569001893 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 926569001894 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926569001895 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 926569001896 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 926569001897 VanW like protein; Region: VanW; pfam04294 926569001898 G5 domain; Region: G5; pfam07501 926569001899 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926569001900 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926569001901 dimer interface [polypeptide binding]; other site 926569001902 ssDNA binding site [nucleotide binding]; other site 926569001903 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569001904 Translin family; Region: Translin; cl00957 926569001905 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 926569001906 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 926569001907 Transcriptional regulator [Transcription]; Region: LytR; COG1316 926569001908 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 926569001909 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926569001910 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 926569001911 NAD(P) binding site [chemical binding]; other site 926569001912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569001913 putative DNA binding site [nucleotide binding]; other site 926569001914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 926569001915 putative Zn2+ binding site [ion binding]; other site 926569001916 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 926569001917 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 926569001918 NADP binding site [chemical binding]; other site 926569001919 active site 926569001920 putative substrate binding site [chemical binding]; other site 926569001921 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926569001922 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569001923 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926569001924 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926569001925 Walker A/P-loop; other site 926569001926 ATP binding site [chemical binding]; other site 926569001927 Q-loop/lid; other site 926569001928 ABC transporter signature motif; other site 926569001929 Walker B; other site 926569001930 D-loop; other site 926569001931 H-loop/switch region; other site 926569001932 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926569001933 putative carbohydrate binding site [chemical binding]; other site 926569001934 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 926569001935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569001936 S-adenosylmethionine binding site [chemical binding]; other site 926569001937 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 926569001938 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 926569001939 NAD(P) binding site [chemical binding]; other site 926569001940 homodimer interface [polypeptide binding]; other site 926569001941 substrate binding site [chemical binding]; other site 926569001942 active site 926569001943 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 926569001944 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 926569001945 NADP binding site [chemical binding]; other site 926569001946 active site 926569001947 putative substrate binding site [chemical binding]; other site 926569001948 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 926569001949 NeuB family; Region: NeuB; pfam03102 926569001950 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 926569001951 NeuB binding interface [polypeptide binding]; other site 926569001952 putative substrate binding site [chemical binding]; other site 926569001953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569001954 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 926569001955 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 926569001956 ligand binding site; other site 926569001957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926569001958 active site 926569001959 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 926569001960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569001961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569001962 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569001963 flagellin modification protein A; Provisional; Region: PRK09186 926569001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569001965 NAD(P) binding site [chemical binding]; other site 926569001966 active site 926569001967 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 926569001968 ligand binding site; other site 926569001969 tetramer interface; other site 926569001970 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 926569001971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569001972 active site 926569001973 motif I; other site 926569001974 motif II; other site 926569001975 NeuB family; Region: NeuB; pfam03102 926569001976 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 926569001977 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 926569001978 ligand binding site; other site 926569001979 tetramer interface; other site 926569001980 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926569001981 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 926569001982 putative ligand binding site [chemical binding]; other site 926569001983 putative NAD binding site [chemical binding]; other site 926569001984 catalytic site [active] 926569001985 classical (c) SDRs; Region: SDR_c; cd05233 926569001986 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 926569001987 NAD(P) binding site [chemical binding]; other site 926569001988 active site 926569001989 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 926569001990 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926569001991 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 926569001992 metal-binding site 926569001993 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569001994 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926569001995 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926569001996 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 926569001997 metal-binding site 926569001998 Response regulator receiver domain; Region: Response_reg; pfam00072 926569001999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002000 active site 926569002001 phosphorylation site [posttranslational modification] 926569002002 intermolecular recognition site; other site 926569002003 dimerization interface [polypeptide binding]; other site 926569002004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569002005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569002006 metal binding site [ion binding]; metal-binding site 926569002007 active site 926569002008 I-site; other site 926569002009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002010 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002013 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002014 GAF domain; Region: GAF_3; pfam13492 926569002015 GAF domain; Region: GAF_2; pfam13185 926569002016 GAF domain; Region: GAF; cl17456 926569002017 GAF domain; Region: GAF; pfam01590 926569002018 GAF domain; Region: GAF_2; pfam13185 926569002019 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002020 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002021 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002022 GAF domain; Region: GAF; pfam01590 926569002023 GAF domain; Region: GAF; cl17456 926569002024 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002025 GAF domain; Region: GAF; pfam01590 926569002026 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569002027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569002028 putative active site [active] 926569002029 heme pocket [chemical binding]; other site 926569002030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569002031 dimer interface [polypeptide binding]; other site 926569002032 phosphorylation site [posttranslational modification] 926569002033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002034 ATP binding site [chemical binding]; other site 926569002035 Mg2+ binding site [ion binding]; other site 926569002036 G-X-G motif; other site 926569002037 Response regulator receiver domain; Region: Response_reg; pfam00072 926569002038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002039 active site 926569002040 phosphorylation site [posttranslational modification] 926569002041 intermolecular recognition site; other site 926569002042 dimerization interface [polypeptide binding]; other site 926569002043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926569002044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569002045 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 926569002046 Walker A/P-loop; other site 926569002047 ATP binding site [chemical binding]; other site 926569002048 Q-loop/lid; other site 926569002049 ABC transporter signature motif; other site 926569002050 Walker B; other site 926569002051 D-loop; other site 926569002052 H-loop/switch region; other site 926569002053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 926569002054 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 926569002055 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569002056 Walker A/P-loop; other site 926569002057 ATP binding site [chemical binding]; other site 926569002058 Q-loop/lid; other site 926569002059 ABC transporter signature motif; other site 926569002060 Walker B; other site 926569002061 D-loop; other site 926569002062 H-loop/switch region; other site 926569002063 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 926569002064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 926569002065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002066 dimer interface [polypeptide binding]; other site 926569002067 conserved gate region; other site 926569002068 putative PBP binding loops; other site 926569002069 ABC-ATPase subunit interface; other site 926569002070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926569002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002072 dimer interface [polypeptide binding]; other site 926569002073 conserved gate region; other site 926569002074 putative PBP binding loops; other site 926569002075 ABC-ATPase subunit interface; other site 926569002076 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926569002077 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 926569002078 substrate binding site [chemical binding]; other site 926569002079 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569002080 Thiamine pyrophosphokinase; Region: TPK; cd07995 926569002081 active site 926569002082 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 926569002083 dimerization interface [polypeptide binding]; other site 926569002084 thiamine binding site [chemical binding]; other site 926569002085 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 926569002086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569002087 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 926569002088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002089 dimer interface [polypeptide binding]; other site 926569002090 conserved gate region; other site 926569002091 putative PBP binding loops; other site 926569002092 ABC-ATPase subunit interface; other site 926569002093 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926569002094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002095 dimer interface [polypeptide binding]; other site 926569002096 conserved gate region; other site 926569002097 putative PBP binding loops; other site 926569002098 ABC-ATPase subunit interface; other site 926569002099 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 926569002100 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 926569002101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569002102 H+ Antiporter protein; Region: 2A0121; TIGR00900 926569002103 putative substrate translocation pore; other site 926569002104 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569002105 putative trimer interface [polypeptide binding]; other site 926569002106 putative CoA binding site [chemical binding]; other site 926569002107 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 926569002108 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926569002109 PGAP1-like protein; Region: PGAP1; pfam07819 926569002110 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 926569002111 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 926569002112 G1 box; other site 926569002113 GTP/Mg2+ binding site [chemical binding]; other site 926569002114 G2 box; other site 926569002115 Switch I region; other site 926569002116 G3 box; other site 926569002117 Switch II region; other site 926569002118 G4 box; other site 926569002119 G5 box; other site 926569002120 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 926569002121 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 926569002122 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 926569002123 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 926569002124 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002126 active site 926569002127 phosphorylation site [posttranslational modification] 926569002128 intermolecular recognition site; other site 926569002129 dimerization interface [polypeptide binding]; other site 926569002130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569002131 DNA binding site [nucleotide binding] 926569002132 MarR family; Region: MarR_2; cl17246 926569002133 Bifunctional nuclease; Region: DNase-RNase; pfam02577 926569002134 replicative DNA helicase; Region: DnaB; TIGR00665 926569002135 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 926569002136 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 926569002137 Walker A motif; other site 926569002138 ATP binding site [chemical binding]; other site 926569002139 Walker B motif; other site 926569002140 DNA binding loops [nucleotide binding] 926569002141 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 926569002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569002143 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569002144 Walker A motif; other site 926569002145 ATP binding site [chemical binding]; other site 926569002146 Walker B motif; other site 926569002147 arginine finger; other site 926569002148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569002149 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569002150 Walker A motif; other site 926569002151 ATP binding site [chemical binding]; other site 926569002152 Walker B motif; other site 926569002153 arginine finger; other site 926569002154 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926569002155 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 926569002156 NAD binding site [chemical binding]; other site 926569002157 ligand binding site [chemical binding]; other site 926569002158 catalytic site [active] 926569002159 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002160 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002161 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569002162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569002163 putative active site [active] 926569002164 heme pocket [chemical binding]; other site 926569002165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569002166 dimer interface [polypeptide binding]; other site 926569002167 phosphorylation site [posttranslational modification] 926569002168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002169 ATP binding site [chemical binding]; other site 926569002170 Mg2+ binding site [ion binding]; other site 926569002171 G-X-G motif; other site 926569002172 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926569002173 RibD C-terminal domain; Region: RibD_C; cl17279 926569002174 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926569002175 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 926569002176 active site 926569002177 catalytic triad [active] 926569002178 dimer interface [polypeptide binding]; other site 926569002179 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926569002180 ABC-2 type transporter; Region: ABC2_membrane; cl17235 926569002181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926569002182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569002183 Walker A/P-loop; other site 926569002184 ATP binding site [chemical binding]; other site 926569002185 Q-loop/lid; other site 926569002186 ABC transporter signature motif; other site 926569002187 Walker B; other site 926569002188 D-loop; other site 926569002189 H-loop/switch region; other site 926569002190 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926569002191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569002192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569002193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569002194 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 926569002195 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 926569002196 active site 926569002197 Zn binding site [ion binding]; other site 926569002198 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926569002199 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 926569002200 ligand binding site [chemical binding]; other site 926569002201 NAD binding site [chemical binding]; other site 926569002202 dimerization interface [polypeptide binding]; other site 926569002203 catalytic site [active] 926569002204 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 926569002205 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926569002206 active site 926569002207 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926569002208 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 926569002209 putative oligomer interface [polypeptide binding]; other site 926569002210 putative active site [active] 926569002211 metal binding site [ion binding]; metal-binding site 926569002212 PIN domain; Region: PIN_3; pfam13470 926569002213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 926569002214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926569002215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 926569002216 dimerization interface [polypeptide binding]; other site 926569002217 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 926569002218 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 926569002219 ligand binding site [chemical binding]; other site 926569002220 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 926569002221 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569002222 Walker A/P-loop; other site 926569002223 ATP binding site [chemical binding]; other site 926569002224 Q-loop/lid; other site 926569002225 ABC transporter signature motif; other site 926569002226 Walker B; other site 926569002227 D-loop; other site 926569002228 H-loop/switch region; other site 926569002229 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569002230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569002231 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569002232 TM-ABC transporter signature motif; other site 926569002233 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926569002234 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569002235 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926569002236 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926569002237 transmembrane helices; other site 926569002238 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 926569002239 Hexamer/Pentamer interface [polypeptide binding]; other site 926569002240 central pore; other site 926569002241 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 926569002242 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 926569002243 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 926569002244 Hexamer interface [polypeptide binding]; other site 926569002245 Putative hexagonal pore residue; other site 926569002246 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 926569002247 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 926569002248 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 926569002249 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 926569002250 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 926569002251 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 926569002252 putative hexamer interface [polypeptide binding]; other site 926569002253 putative hexagonal pore; other site 926569002254 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 926569002255 putative hexamer interface [polypeptide binding]; other site 926569002256 putative hexagonal pore; other site 926569002257 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 926569002258 putative catalytic cysteine [active] 926569002259 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 926569002260 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 926569002261 Hexamer interface [polypeptide binding]; other site 926569002262 Putative hexagonal pore residue; other site 926569002263 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 926569002264 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 926569002265 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 926569002266 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 926569002267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926569002268 nucleotide binding site [chemical binding]; other site 926569002269 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 926569002270 putative hexamer interface [polypeptide binding]; other site 926569002271 putative hexagonal pore; other site 926569002272 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 926569002273 putative hexamer interface [polypeptide binding]; other site 926569002274 putative hexagonal pore; other site 926569002275 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569002276 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 926569002277 P-loop; other site 926569002278 Magnesium ion binding site [ion binding]; other site 926569002279 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569002280 Magnesium ion binding site [ion binding]; other site 926569002281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 926569002282 active site 926569002283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569002284 S-adenosylmethionine binding site [chemical binding]; other site 926569002285 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 926569002286 nucleotide binding site/active site [active] 926569002287 HIT family signature motif; other site 926569002288 catalytic residue [active] 926569002289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569002290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569002291 catalytic residue [active] 926569002292 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 926569002293 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 926569002294 magnesium-transporting ATPase; Provisional; Region: PRK15122 926569002295 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569002296 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 926569002297 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926569002298 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 926569002299 Uncharacterized conserved protein [Function unknown]; Region: COG2898 926569002300 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 926569002301 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 926569002302 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 926569002303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569002304 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 926569002305 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926569002306 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 926569002307 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 926569002308 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 926569002309 FeoA domain; Region: FeoA; pfam04023 926569002310 FeoA domain; Region: FeoA; pfam04023 926569002311 manganese transport protein MntH; Reviewed; Region: PRK00701 926569002312 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 926569002313 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 926569002314 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 926569002315 ligand binding site [chemical binding]; other site 926569002316 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 926569002317 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569002318 Walker A/P-loop; other site 926569002319 ATP binding site [chemical binding]; other site 926569002320 Q-loop/lid; other site 926569002321 ABC transporter signature motif; other site 926569002322 Walker B; other site 926569002323 D-loop; other site 926569002324 H-loop/switch region; other site 926569002325 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569002326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569002327 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569002328 TM-ABC transporter signature motif; other site 926569002329 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569002330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569002331 TM-ABC transporter signature motif; other site 926569002332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569002333 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569002334 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 926569002335 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569002336 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 926569002337 putative ligand binding pocket/active site [active] 926569002338 putative metal binding site [ion binding]; other site 926569002339 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 926569002340 Domain of unknown function DUF21; Region: DUF21; pfam01595 926569002341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926569002342 Transporter associated domain; Region: CorC_HlyC; smart01091 926569002343 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926569002344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569002345 Coenzyme A binding pocket [chemical binding]; other site 926569002346 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 926569002347 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 926569002348 Walker A/P-loop; other site 926569002349 ATP binding site [chemical binding]; other site 926569002350 Q-loop/lid; other site 926569002351 ABC transporter signature motif; other site 926569002352 Walker B; other site 926569002353 D-loop; other site 926569002354 H-loop/switch region; other site 926569002355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 926569002356 NMT1/THI5 like; Region: NMT1; pfam09084 926569002357 substrate binding pocket [chemical binding]; other site 926569002358 membrane-bound complex binding site; other site 926569002359 hinge residues; other site 926569002360 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 926569002361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002362 dimer interface [polypeptide binding]; other site 926569002363 conserved gate region; other site 926569002364 putative PBP binding loops; other site 926569002365 ABC-ATPase subunit interface; other site 926569002366 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 926569002367 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569002368 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 926569002369 generic binding surface II; other site 926569002370 generic binding surface I; other site 926569002371 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 926569002372 putative active site [active] 926569002373 putative catalytic site [active] 926569002374 putative Mg binding site IVb [ion binding]; other site 926569002375 putative phosphate binding site [ion binding]; other site 926569002376 putative DNA binding site [nucleotide binding]; other site 926569002377 putative Mg binding site IVa [ion binding]; other site 926569002378 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 926569002379 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 926569002380 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 926569002381 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926569002382 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926569002383 metal-binding site [ion binding] 926569002384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569002385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926569002386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569002387 dimerization interface [polypeptide binding]; other site 926569002388 putative DNA binding site [nucleotide binding]; other site 926569002389 putative Zn2+ binding site [ion binding]; other site 926569002390 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926569002391 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926569002392 putative acyl-acceptor binding pocket; other site 926569002393 potential frameshift: common BLAST hit: gi|186471051|ref|YP_001862369.1| FAD dependent oxidoreductase 926569002394 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 926569002395 potential frameshift: common BLAST hit: gi|88603314|ref|YP_503492.1| FAD dependent oxidoreductase 926569002396 carotene isomerase; Region: carot_isom; TIGR02730 926569002397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569002398 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 926569002399 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 926569002400 Walker A/P-loop; other site 926569002401 ATP binding site [chemical binding]; other site 926569002402 Q-loop/lid; other site 926569002403 ABC transporter signature motif; other site 926569002404 Walker B; other site 926569002405 D-loop; other site 926569002406 H-loop/switch region; other site 926569002407 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 926569002408 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 926569002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002410 dimer interface [polypeptide binding]; other site 926569002411 conserved gate region; other site 926569002412 putative PBP binding loops; other site 926569002413 ABC-ATPase subunit interface; other site 926569002414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002415 dimer interface [polypeptide binding]; other site 926569002416 conserved gate region; other site 926569002417 putative PBP binding loops; other site 926569002418 ABC-ATPase subunit interface; other site 926569002419 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926569002420 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 926569002421 active site 926569002422 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926569002423 SnoaL-like domain; Region: SnoaL_3; pfam13474 926569002424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569002425 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569002426 active site 926569002427 catalytic tetrad [active] 926569002428 Dam-replacing family; Region: DRP; pfam06044 926569002429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569002430 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926569002431 FtsX-like permease family; Region: FtsX; pfam02687 926569002432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569002433 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569002434 Walker A/P-loop; other site 926569002435 ATP binding site [chemical binding]; other site 926569002436 Q-loop/lid; other site 926569002437 ABC transporter signature motif; other site 926569002438 Walker B; other site 926569002439 D-loop; other site 926569002440 H-loop/switch region; other site 926569002441 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 926569002442 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926569002443 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 926569002444 HlyD family secretion protein; Region: HlyD_3; pfam13437 926569002445 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 926569002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569002447 S-adenosylmethionine binding site [chemical binding]; other site 926569002448 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 926569002449 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 926569002450 active site 926569002451 HIGH motif; other site 926569002452 dimer interface [polypeptide binding]; other site 926569002453 KMSKS motif; other site 926569002454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926569002455 RNA binding surface [nucleotide binding]; other site 926569002456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569002457 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569002458 Walker A/P-loop; other site 926569002459 ATP binding site [chemical binding]; other site 926569002460 Q-loop/lid; other site 926569002461 ABC transporter signature motif; other site 926569002462 Walker B; other site 926569002463 D-loop; other site 926569002464 H-loop/switch region; other site 926569002465 CARDB; Region: CARDB; pfam07705 926569002466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569002467 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926569002468 FtsX-like permease family; Region: FtsX; pfam02687 926569002469 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 926569002470 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926569002471 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 926569002472 putative active site [active] 926569002473 catalytic triad [active] 926569002474 putative dimer interface [polypeptide binding]; other site 926569002475 NAD synthetase; Provisional; Region: PRK13980 926569002476 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 926569002477 homodimer interface [polypeptide binding]; other site 926569002478 NAD binding pocket [chemical binding]; other site 926569002479 ATP binding pocket [chemical binding]; other site 926569002480 Mg binding site [ion binding]; other site 926569002481 active-site loop [active] 926569002482 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 926569002483 putative active site [active] 926569002484 putative metal binding residues [ion binding]; other site 926569002485 signature motif; other site 926569002486 putative triphosphate binding site [ion binding]; other site 926569002487 dimer interface [polypeptide binding]; other site 926569002488 Family description; Region: VCBS; pfam13517 926569002489 Family description; Region: VCBS; pfam13517 926569002490 Family description; Region: VCBS; pfam13517 926569002491 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926569002492 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 926569002493 Transcriptional regulator [Transcription]; Region: LytR; COG1316 926569002494 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 926569002495 Leucine rich repeat; Region: LRR_8; pfam13855 926569002496 EamA-like transporter family; Region: EamA; pfam00892 926569002497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569002498 dimerization interface [polypeptide binding]; other site 926569002499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569002500 dimer interface [polypeptide binding]; other site 926569002501 phosphorylation site [posttranslational modification] 926569002502 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 926569002503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002504 ATP binding site [chemical binding]; other site 926569002505 Mg2+ binding site [ion binding]; other site 926569002506 G-X-G motif; other site 926569002507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569002508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002509 active site 926569002510 phosphorylation site [posttranslational modification] 926569002511 intermolecular recognition site; other site 926569002512 dimerization interface [polypeptide binding]; other site 926569002513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569002514 DNA binding site [nucleotide binding] 926569002515 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926569002516 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 926569002517 HlyD family secretion protein; Region: HlyD_3; pfam13437 926569002518 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569002519 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569002520 Walker A/P-loop; other site 926569002521 ATP binding site [chemical binding]; other site 926569002522 Q-loop/lid; other site 926569002523 ABC transporter signature motif; other site 926569002524 Walker B; other site 926569002525 D-loop; other site 926569002526 H-loop/switch region; other site 926569002527 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569002528 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926569002529 FtsX-like permease family; Region: FtsX; pfam02687 926569002530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569002531 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 926569002532 SnoaL-like domain; Region: SnoaL_2; pfam12680 926569002533 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926569002534 putative catalytic site [active] 926569002535 putative metal binding site [ion binding]; other site 926569002536 putative phosphate binding site [ion binding]; other site 926569002537 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 926569002538 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 926569002539 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 926569002540 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926569002541 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926569002542 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926569002543 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002544 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926569002545 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926569002546 Domain of unknown function DUF11; Region: DUF11; cl17728 926569002547 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002548 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002549 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002550 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002551 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002552 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569002553 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 926569002554 active site 926569002555 catalytic site [active] 926569002556 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 926569002557 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 926569002558 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 926569002559 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926569002560 dimer interface [polypeptide binding]; other site 926569002561 active site 926569002562 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926569002563 dimer interface [polypeptide binding]; other site 926569002564 active site 926569002565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002567 dimer interface [polypeptide binding]; other site 926569002568 conserved gate region; other site 926569002569 putative PBP binding loops; other site 926569002570 ABC-ATPase subunit interface; other site 926569002571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 926569002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002573 putative PBP binding loops; other site 926569002574 ABC-ATPase subunit interface; other site 926569002575 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569002576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569002577 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 926569002578 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569002579 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926569002580 non-specific DNA interactions [nucleotide binding]; other site 926569002581 DNA binding site [nucleotide binding] 926569002582 sequence specific DNA binding site [nucleotide binding]; other site 926569002583 putative cAMP binding site [chemical binding]; other site 926569002584 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569002585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569002586 nucleotide binding site [chemical binding]; other site 926569002587 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 926569002588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569002589 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 926569002590 Walker A/P-loop; other site 926569002591 ATP binding site [chemical binding]; other site 926569002592 Q-loop/lid; other site 926569002593 ABC transporter signature motif; other site 926569002594 Walker B; other site 926569002595 D-loop; other site 926569002596 H-loop/switch region; other site 926569002597 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 926569002598 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 926569002599 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569002600 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 926569002601 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926569002602 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569002603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569002604 NAD(P) binding site [chemical binding]; other site 926569002605 active site 926569002606 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926569002607 DNA-binding site [nucleotide binding]; DNA binding site 926569002608 RNA-binding motif; other site 926569002609 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 926569002610 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 926569002611 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 926569002612 active site 926569002613 catalytic residues [active] 926569002614 metal binding site [ion binding]; metal-binding site 926569002615 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 926569002616 AsnC family; Region: AsnC_trans_reg; pfam01037 926569002617 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 926569002618 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 926569002619 substrate binding site [chemical binding]; other site 926569002620 ligand binding site [chemical binding]; other site 926569002621 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 926569002622 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 926569002623 substrate binding site [chemical binding]; other site 926569002624 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 926569002625 tartrate dehydrogenase; Region: TTC; TIGR02089 926569002626 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 926569002627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926569002628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569002629 sugar efflux transporter; Region: 2A0120; TIGR00899 926569002630 putative substrate translocation pore; other site 926569002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569002632 sugar efflux transporter; Region: 2A0120; TIGR00899 926569002633 putative substrate translocation pore; other site 926569002634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569002635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569002636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569002637 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 926569002638 NADH dehydrogenase subunit B; Validated; Region: PRK06411 926569002639 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 926569002640 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 926569002641 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 926569002642 NADH dehydrogenase subunit D; Validated; Region: PRK06075 926569002643 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 926569002644 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 926569002645 putative dimer interface [polypeptide binding]; other site 926569002646 [2Fe-2S] cluster binding site [ion binding]; other site 926569002647 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 926569002648 SLBB domain; Region: SLBB; pfam10531 926569002649 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 926569002650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569002651 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 926569002652 catalytic loop [active] 926569002653 iron binding site [ion binding]; other site 926569002654 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 926569002655 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 926569002656 molybdopterin cofactor binding site; other site 926569002657 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 926569002658 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 926569002659 molybdopterin cofactor binding site; other site 926569002660 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 926569002661 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 926569002662 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 926569002663 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 926569002664 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 926569002665 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 926569002666 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 926569002667 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 926569002668 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 926569002669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569002670 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 926569002671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569002672 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 926569002673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569002674 Integral membrane protein DUF92; Region: DUF92; pfam01940 926569002675 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926569002676 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926569002677 inhibitor-cofactor binding pocket; inhibition site 926569002678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569002679 catalytic residue [active] 926569002680 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 926569002681 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 926569002682 motif 1; other site 926569002683 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 926569002684 putative deacylase active site [active] 926569002685 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 926569002686 anticodon binding site; other site 926569002687 CAAX protease self-immunity; Region: Abi; pfam02517 926569002688 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 926569002689 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926569002690 E3 interaction surface; other site 926569002691 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 926569002692 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 926569002693 putative trimer interface [polypeptide binding]; other site 926569002694 putative CoA binding site [chemical binding]; other site 926569002695 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 926569002696 active site 926569002697 DNA binding site [nucleotide binding] 926569002698 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 926569002699 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926569002700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 926569002701 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 926569002702 active site 926569002703 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569002704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569002705 NAD(P) binding site [chemical binding]; other site 926569002706 active site 926569002707 Rubrerythrin [Energy production and conversion]; Region: COG1592 926569002708 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 926569002709 binuclear metal center [ion binding]; other site 926569002710 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 926569002711 iron binding site [ion binding]; other site 926569002712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569002713 dimerization interface [polypeptide binding]; other site 926569002714 putative DNA binding site [nucleotide binding]; other site 926569002715 putative Zn2+ binding site [ion binding]; other site 926569002716 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 926569002717 arsenical-resistance protein; Region: acr3; TIGR00832 926569002718 hypothetical protein; Provisional; Region: PRK11770 926569002719 Domain of unknown function (DUF307); Region: DUF307; pfam03733 926569002720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569002721 dimerization interface [polypeptide binding]; other site 926569002722 GAF domain; Region: GAF_2; pfam13185 926569002723 GAF domain; Region: GAF; pfam01590 926569002724 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002725 GAF domain; Region: GAF; pfam01590 926569002726 GAF domain; Region: GAF_3; pfam13492 926569002727 GAF domain; Region: GAF_2; pfam13185 926569002728 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002729 GAF domain; Region: GAF_3; pfam13492 926569002730 GAF domain; Region: GAF_2; pfam13185 926569002731 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569002733 metal binding site [ion binding]; metal-binding site 926569002734 active site 926569002735 I-site; other site 926569002736 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 926569002737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 926569002738 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 926569002739 Recombination protein O N terminal; Region: RecO_N; pfam11967 926569002740 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 926569002741 Recombination protein O C terminal; Region: RecO_C; pfam02565 926569002742 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 926569002743 active site 926569002744 catalytic motif [active] 926569002745 Zn binding site [ion binding]; other site 926569002746 Domain of unknown function DUF21; Region: DUF21; pfam01595 926569002747 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 926569002748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926569002749 Transporter associated domain; Region: CorC_HlyC; smart01091 926569002750 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 926569002751 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 926569002752 Substrate binding site; other site 926569002753 Mg++ binding site; other site 926569002754 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 926569002755 active site 926569002756 substrate binding site [chemical binding]; other site 926569002757 CoA binding site [chemical binding]; other site 926569002758 Oligomerisation domain; Region: Oligomerisation; pfam02410 926569002759 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 926569002760 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 926569002761 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 926569002762 Protein of unknown function (DUF461); Region: DUF461; pfam04314 926569002763 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 926569002764 DNA primase; Validated; Region: dnaG; PRK05667 926569002765 CHC2 zinc finger; Region: zf-CHC2; cl17510 926569002766 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 926569002767 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 926569002768 active site 926569002769 metal binding site [ion binding]; metal-binding site 926569002770 interdomain interaction site; other site 926569002771 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 926569002772 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569002773 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569002774 glycyl-tRNA synthetase; Provisional; Region: PRK14908 926569002775 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 926569002776 dimer interface [polypeptide binding]; other site 926569002777 motif 1; other site 926569002778 active site 926569002779 motif 2; other site 926569002780 motif 3; other site 926569002781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569002782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002783 active site 926569002784 phosphorylation site [posttranslational modification] 926569002785 intermolecular recognition site; other site 926569002786 dimerization interface [polypeptide binding]; other site 926569002787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569002788 DNA binding residues [nucleotide binding] 926569002789 dimerization interface [polypeptide binding]; other site 926569002790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569002791 dimerization interface [polypeptide binding]; other site 926569002792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569002793 Histidine kinase; Region: HisKA_3; pfam07730 926569002794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002795 ATP binding site [chemical binding]; other site 926569002796 Mg2+ binding site [ion binding]; other site 926569002797 G-X-G motif; other site 926569002798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569002799 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926569002800 FtsX-like permease family; Region: FtsX; pfam02687 926569002801 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569002802 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569002803 Walker A/P-loop; other site 926569002804 ATP binding site [chemical binding]; other site 926569002805 Q-loop/lid; other site 926569002806 ABC transporter signature motif; other site 926569002807 Walker B; other site 926569002808 D-loop; other site 926569002809 H-loop/switch region; other site 926569002810 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 926569002811 HlyD family secretion protein; Region: HlyD_3; pfam13437 926569002812 Uncharacterized conserved protein [Function unknown]; Region: COG3391 926569002813 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 926569002814 alpha-galactosidase; Provisional; Region: PRK15076 926569002815 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 926569002816 NAD binding site [chemical binding]; other site 926569002817 sugar binding site [chemical binding]; other site 926569002818 divalent metal binding site [ion binding]; other site 926569002819 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569002820 dimer interface [polypeptide binding]; other site 926569002821 alpha-galactosidase; Provisional; Region: PRK15076 926569002822 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 926569002823 NAD binding site [chemical binding]; other site 926569002824 sugar binding site [chemical binding]; other site 926569002825 divalent metal binding site [ion binding]; other site 926569002826 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569002827 dimer interface [polypeptide binding]; other site 926569002828 Predicted membrane protein [Function unknown]; Region: COG4818 926569002829 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 926569002830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569002831 Walker A/P-loop; other site 926569002832 ATP binding site [chemical binding]; other site 926569002833 Q-loop/lid; other site 926569002834 ABC transporter signature motif; other site 926569002835 Walker B; other site 926569002836 D-loop; other site 926569002837 H-loop/switch region; other site 926569002838 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569002839 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 926569002840 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 926569002841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002842 dimer interface [polypeptide binding]; other site 926569002843 conserved gate region; other site 926569002844 putative PBP binding loops; other site 926569002845 ABC-ATPase subunit interface; other site 926569002846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926569002847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002848 dimer interface [polypeptide binding]; other site 926569002849 conserved gate region; other site 926569002850 putative PBP binding loops; other site 926569002851 ABC-ATPase subunit interface; other site 926569002852 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 926569002853 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 926569002854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 926569002855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569002856 Walker A/P-loop; other site 926569002857 ATP binding site [chemical binding]; other site 926569002858 Q-loop/lid; other site 926569002859 ABC transporter signature motif; other site 926569002860 Walker B; other site 926569002861 D-loop; other site 926569002862 H-loop/switch region; other site 926569002863 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569002864 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569002865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002866 active site 926569002867 phosphorylation site [posttranslational modification] 926569002868 intermolecular recognition site; other site 926569002869 dimerization interface [polypeptide binding]; other site 926569002870 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 926569002871 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 926569002872 ligand binding site [chemical binding]; other site 926569002873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002874 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569002875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569002876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569002877 dimer interface [polypeptide binding]; other site 926569002878 phosphorylation site [posttranslational modification] 926569002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002880 ATP binding site [chemical binding]; other site 926569002881 Mg2+ binding site [ion binding]; other site 926569002882 G-X-G motif; other site 926569002883 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569002884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002885 active site 926569002886 phosphorylation site [posttranslational modification] 926569002887 intermolecular recognition site; other site 926569002888 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926569002889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926569002890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926569002891 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 926569002892 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 926569002893 Ligand Binding Site [chemical binding]; other site 926569002894 TilS substrate C-terminal domain; Region: TilS_C; smart00977 926569002895 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569002896 DNA binding site [nucleotide binding] 926569002897 Transcriptional regulator [Transcription]; Region: LytR; COG1316 926569002898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569002899 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569002900 GAF domain; Region: GAF; cl17456 926569002901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569002902 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 926569002903 dimer interface [polypeptide binding]; other site 926569002904 phosphorylation site [posttranslational modification] 926569002905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569002906 ATP binding site [chemical binding]; other site 926569002907 Mg2+ binding site [ion binding]; other site 926569002908 G-X-G motif; other site 926569002909 MarR family; Region: MarR_2; pfam12802 926569002910 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569002911 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569002912 nucleotide binding site [chemical binding]; other site 926569002913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926569002914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569002915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569002916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002917 dimer interface [polypeptide binding]; other site 926569002918 conserved gate region; other site 926569002919 putative PBP binding loops; other site 926569002920 ABC-ATPase subunit interface; other site 926569002921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569002922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569002923 dimer interface [polypeptide binding]; other site 926569002924 conserved gate region; other site 926569002925 putative PBP binding loops; other site 926569002926 ABC-ATPase subunit interface; other site 926569002927 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 926569002928 alpha-galactosidase; Provisional; Region: PRK15076 926569002929 NAD binding site [chemical binding]; other site 926569002930 sugar binding site [chemical binding]; other site 926569002931 divalent metal binding site [ion binding]; other site 926569002932 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569002933 dimer interface [polypeptide binding]; other site 926569002934 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 926569002935 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926569002936 dimer interface [polypeptide binding]; other site 926569002937 active site 926569002938 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926569002939 dimer interface [polypeptide binding]; other site 926569002940 active site 926569002941 phosphoenolpyruvate synthase; Validated; Region: PRK06241 926569002942 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 926569002943 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 926569002944 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926569002945 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926569002946 protein binding site [polypeptide binding]; other site 926569002947 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 926569002948 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 926569002949 gating phenylalanine in ion channel; other site 926569002950 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569002951 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926569002952 Response regulator receiver domain; Region: Response_reg; pfam00072 926569002953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569002954 active site 926569002955 phosphorylation site [posttranslational modification] 926569002956 intermolecular recognition site; other site 926569002957 dimerization interface [polypeptide binding]; other site 926569002958 AAA domain; Region: AAA_31; pfam13614 926569002959 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 926569002960 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 926569002961 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926569002962 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569002963 Haem-binding domain; Region: Haem_bd; pfam14376 926569002964 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569002965 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569002966 metal binding site [ion binding]; metal-binding site 926569002967 active site 926569002968 I-site; other site 926569002969 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002970 GAF domain; Region: GAF_3; pfam13492 926569002971 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002972 GAF domain; Region: GAF; pfam01590 926569002973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569002974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569002975 dimerization interface [polypeptide binding]; other site 926569002976 PAS domain S-box; Region: sensory_box; TIGR00229 926569002977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569002978 putative active site [active] 926569002979 heme pocket [chemical binding]; other site 926569002980 PAS domain S-box; Region: sensory_box; TIGR00229 926569002981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569002982 putative active site [active] 926569002983 heme pocket [chemical binding]; other site 926569002984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002985 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 926569002986 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569002987 GAF domain; Region: GAF; pfam01590 926569002988 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569002989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569002990 Zn2+ binding site [ion binding]; other site 926569002991 Mg2+ binding site [ion binding]; other site 926569002992 O-Antigen ligase; Region: Wzy_C; pfam04932 926569002993 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 926569002994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569002995 TPR motif; other site 926569002996 binding surface 926569002997 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 926569002998 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 926569002999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569003000 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 926569003001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569003002 DNA binding residues [nucleotide binding] 926569003003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003004 active site 926569003005 phosphorylation site [posttranslational modification] 926569003006 intermolecular recognition site; other site 926569003007 dimerization interface [polypeptide binding]; other site 926569003008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569003009 dimerization interface [polypeptide binding]; other site 926569003010 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 926569003011 cyclase homology domain; Region: CHD; cd07302 926569003012 nucleotidyl binding site; other site 926569003013 metal binding site [ion binding]; metal-binding site 926569003014 dimer interface [polypeptide binding]; other site 926569003015 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 926569003016 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 926569003017 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 926569003018 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 926569003019 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 926569003020 Ligand Binding Site [chemical binding]; other site 926569003021 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 926569003022 GAF domain; Region: GAF_3; pfam13492 926569003023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003024 dimer interface [polypeptide binding]; other site 926569003025 phosphorylation site [posttranslational modification] 926569003026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003027 ATP binding site [chemical binding]; other site 926569003028 Mg2+ binding site [ion binding]; other site 926569003029 G-X-G motif; other site 926569003030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569003031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003032 active site 926569003033 phosphorylation site [posttranslational modification] 926569003034 intermolecular recognition site; other site 926569003035 dimerization interface [polypeptide binding]; other site 926569003036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569003037 DNA binding site [nucleotide binding] 926569003038 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 926569003039 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 926569003040 putative N- and C-terminal domain interface [polypeptide binding]; other site 926569003041 putative active site [active] 926569003042 MgATP binding site [chemical binding]; other site 926569003043 catalytic site [active] 926569003044 metal binding site [ion binding]; metal-binding site 926569003045 putative carbohydrate binding site [chemical binding]; other site 926569003046 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926569003047 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 926569003048 putative NAD(P) binding site [chemical binding]; other site 926569003049 active site 926569003050 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 926569003051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569003052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569003053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003054 active site 926569003055 phosphorylation site [posttranslational modification] 926569003056 intermolecular recognition site; other site 926569003057 dimerization interface [polypeptide binding]; other site 926569003058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569003059 DNA binding site [nucleotide binding] 926569003060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569003061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569003062 dimerization interface [polypeptide binding]; other site 926569003063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003064 dimer interface [polypeptide binding]; other site 926569003065 phosphorylation site [posttranslational modification] 926569003066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003067 ATP binding site [chemical binding]; other site 926569003068 Mg2+ binding site [ion binding]; other site 926569003069 G-X-G motif; other site 926569003070 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926569003071 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926569003072 protein binding site [polypeptide binding]; other site 926569003073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926569003074 protein binding site [polypeptide binding]; other site 926569003075 transcription termination factor Rho; Provisional; Region: rho; PRK09376 926569003076 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 926569003077 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 926569003078 RNA binding site [nucleotide binding]; other site 926569003079 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 926569003080 Walker A motif; other site 926569003081 ATP binding site [chemical binding]; other site 926569003082 Walker B motif; other site 926569003083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569003084 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569003085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569003086 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569003087 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 926569003088 putative active site [active] 926569003089 dimerization interface [polypeptide binding]; other site 926569003090 putative tRNAtyr binding site [nucleotide binding]; other site 926569003091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926569003092 phosphate binding site [ion binding]; other site 926569003093 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 926569003094 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 926569003095 FAD binding pocket [chemical binding]; other site 926569003096 conserved FAD binding motif [chemical binding]; other site 926569003097 phosphate binding motif [ion binding]; other site 926569003098 beta-alpha-beta structure motif; other site 926569003099 NAD binding pocket [chemical binding]; other site 926569003100 selenophosphate synthetase; Provisional; Region: PRK00943 926569003101 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 926569003102 dimerization interface [polypeptide binding]; other site 926569003103 putative ATP binding site [chemical binding]; other site 926569003104 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 926569003105 Peptidase family U32; Region: Peptidase_U32; pfam01136 926569003106 Collagenase; Region: DUF3656; pfam12392 926569003107 translocation protein TolB; Provisional; Region: tolB; PRK04922 926569003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 926569003109 YbbR-like protein; Region: YbbR; pfam07949 926569003110 YbbR-like protein; Region: YbbR; pfam07949 926569003111 Uncharacterized conserved protein [Function unknown]; Region: COG1624 926569003112 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 926569003113 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 926569003114 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 926569003115 CoA-binding site [chemical binding]; other site 926569003116 ATP-binding [chemical binding]; other site 926569003117 Tic20-like protein; Region: Tic20; pfam09685 926569003118 CAAX protease self-immunity; Region: Abi; pfam02517 926569003119 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 926569003120 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926569003121 Domain of unknown function DUF11; Region: DUF11; pfam01345 926569003122 Protein of unknown function DUF58; Region: DUF58; pfam01882 926569003123 MoxR-like ATPases [General function prediction only]; Region: COG0714 926569003124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569003125 Walker A motif; other site 926569003126 ATP binding site [chemical binding]; other site 926569003127 Walker B motif; other site 926569003128 arginine finger; other site 926569003129 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 926569003130 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 926569003131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569003132 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926569003133 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569003134 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926569003135 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 926569003136 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 926569003137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569003138 Walker A/P-loop; other site 926569003139 ATP binding site [chemical binding]; other site 926569003140 Q-loop/lid; other site 926569003141 ABC transporter signature motif; other site 926569003142 Walker B; other site 926569003143 D-loop; other site 926569003144 H-loop/switch region; other site 926569003145 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926569003146 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 926569003147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569003148 S-adenosylmethionine binding site [chemical binding]; other site 926569003149 peptide chain release factor 1; Validated; Region: prfA; PRK00591 926569003150 This domain is found in peptide chain release factors; Region: PCRF; smart00937 926569003151 RF-1 domain; Region: RF-1; pfam00472 926569003152 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 926569003153 nickel binding site [ion binding]; other site 926569003154 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 926569003155 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 926569003156 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 926569003157 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 926569003158 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 926569003159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569003160 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 926569003161 4Fe-4S binding domain; Region: Fer4; pfam00037 926569003162 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 926569003163 molybdopterin cofactor binding site; other site 926569003164 rod shape-determining protein MreB; Provisional; Region: PRK13927 926569003165 MreB and similar proteins; Region: MreB_like; cd10225 926569003166 nucleotide binding site [chemical binding]; other site 926569003167 Mg binding site [ion binding]; other site 926569003168 putative protofilament interaction site [polypeptide binding]; other site 926569003169 RodZ interaction site [polypeptide binding]; other site 926569003170 rod shape-determining protein MreC; Provisional; Region: PRK13922 926569003171 Protein of unknown function (DUF972); Region: DUF972; pfam06156 926569003172 rod shape-determining protein MreC; Region: MreC; pfam04085 926569003173 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 926569003174 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926569003175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926569003176 septum site-determining protein MinC; Region: minC; TIGR01222 926569003177 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 926569003178 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 926569003179 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 926569003180 Switch I; other site 926569003181 Switch II; other site 926569003182 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 926569003183 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 926569003184 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 926569003185 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926569003186 active site 926569003187 HIGH motif; other site 926569003188 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926569003189 active site 926569003190 KMSKS motif; other site 926569003191 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 926569003192 GIY-YIG motif/motif A; other site 926569003193 putative active site [active] 926569003194 putative metal binding site [ion binding]; other site 926569003195 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 926569003196 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926569003197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926569003198 RNA binding surface [nucleotide binding]; other site 926569003199 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926569003200 active site 926569003201 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 926569003202 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 926569003203 tetramer interface [polypeptide binding]; other site 926569003204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569003205 catalytic residue [active] 926569003206 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003207 GAF domain; Region: GAF; pfam01590 926569003208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569003209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569003210 metal binding site [ion binding]; metal-binding site 926569003211 active site 926569003212 I-site; other site 926569003213 GAF domain; Region: GAF; pfam01590 926569003214 GAF domain; Region: GAF_2; pfam13185 926569003215 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003216 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003217 GAF domain; Region: GAF_3; pfam13492 926569003218 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569003219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569003220 Zn2+ binding site [ion binding]; other site 926569003221 Mg2+ binding site [ion binding]; other site 926569003222 purine nucleoside phosphorylase; Provisional; Region: PRK08202 926569003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 926569003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569003225 Coenzyme A binding pocket [chemical binding]; other site 926569003226 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 926569003227 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 926569003228 RNA binding site [nucleotide binding]; other site 926569003229 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 926569003230 RNA binding site [nucleotide binding]; other site 926569003231 S1 RNA binding domain; Region: S1; pfam00575 926569003232 RNA binding site [nucleotide binding]; other site 926569003233 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 926569003234 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 926569003235 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926569003236 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 926569003237 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 926569003238 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 926569003239 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926569003240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569003241 Walker A/P-loop; other site 926569003242 ATP binding site [chemical binding]; other site 926569003243 Q-loop/lid; other site 926569003244 ABC transporter signature motif; other site 926569003245 Walker B; other site 926569003246 D-loop; other site 926569003247 H-loop/switch region; other site 926569003248 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926569003249 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 926569003250 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926569003251 Integral membrane protein DUF95; Region: DUF95; pfam01944 926569003252 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 926569003253 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 926569003254 active site 926569003255 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 926569003256 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 926569003257 putative NAD(P) binding site [chemical binding]; other site 926569003258 putative active site [active] 926569003259 GDP-mannose 4,6-dehydratase; Region: PLN02653 926569003260 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 926569003261 NADP-binding site; other site 926569003262 homotetramer interface [polypeptide binding]; other site 926569003263 substrate binding site [chemical binding]; other site 926569003264 homodimer interface [polypeptide binding]; other site 926569003265 active site 926569003266 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926569003267 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 926569003268 active site 926569003269 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 926569003270 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926569003271 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 926569003272 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926569003273 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 926569003274 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926569003275 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 926569003276 RPB10 interaction site [polypeptide binding]; other site 926569003277 RPB11 interaction site [polypeptide binding]; other site 926569003278 RPB3 interaction site [polypeptide binding]; other site 926569003279 RPB12 interaction site [polypeptide binding]; other site 926569003280 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926569003281 RPB1 interaction site [polypeptide binding]; other site 926569003282 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 926569003283 S17 interaction site [polypeptide binding]; other site 926569003284 S8 interaction site; other site 926569003285 16S rRNA interaction site [nucleotide binding]; other site 926569003286 streptomycin interaction site [chemical binding]; other site 926569003287 23S rRNA interaction site [nucleotide binding]; other site 926569003288 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 926569003289 30S ribosomal protein S7; Validated; Region: PRK05302 926569003290 elongation factor G; Reviewed; Region: PRK00007 926569003291 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 926569003292 G1 box; other site 926569003293 putative GEF interaction site [polypeptide binding]; other site 926569003294 GTP/Mg2+ binding site [chemical binding]; other site 926569003295 Switch I region; other site 926569003296 G2 box; other site 926569003297 G3 box; other site 926569003298 Switch II region; other site 926569003299 G4 box; other site 926569003300 G5 box; other site 926569003301 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 926569003302 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 926569003303 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 926569003304 elongation factor Tu; Reviewed; Region: PRK00049 926569003305 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 926569003306 G1 box; other site 926569003307 GEF interaction site [polypeptide binding]; other site 926569003308 GTP/Mg2+ binding site [chemical binding]; other site 926569003309 Switch I region; other site 926569003310 G2 box; other site 926569003311 G3 box; other site 926569003312 Switch II region; other site 926569003313 G4 box; other site 926569003314 G5 box; other site 926569003315 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 926569003316 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 926569003317 Antibiotic Binding Site [chemical binding]; other site 926569003318 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 926569003319 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 926569003320 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 926569003321 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 926569003322 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 926569003323 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 926569003324 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 926569003325 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 926569003326 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 926569003327 putative translocon binding site; other site 926569003328 protein-rRNA interface [nucleotide binding]; other site 926569003329 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 926569003330 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 926569003331 G-X-X-G motif; other site 926569003332 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 926569003333 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 926569003334 23S rRNA interface [nucleotide binding]; other site 926569003335 5S rRNA interface [nucleotide binding]; other site 926569003336 putative antibiotic binding site [chemical binding]; other site 926569003337 L25 interface [polypeptide binding]; other site 926569003338 L27 interface [polypeptide binding]; other site 926569003339 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 926569003340 23S rRNA interface [nucleotide binding]; other site 926569003341 putative translocon interaction site; other site 926569003342 signal recognition particle (SRP54) interaction site; other site 926569003343 L23 interface [polypeptide binding]; other site 926569003344 trigger factor interaction site; other site 926569003345 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 926569003346 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 926569003347 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 926569003348 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 926569003349 RNA binding site [nucleotide binding]; other site 926569003350 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 926569003351 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 926569003352 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 926569003353 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 926569003354 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 926569003355 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 926569003356 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926569003357 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926569003358 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 926569003359 23S rRNA interface [nucleotide binding]; other site 926569003360 5S rRNA interface [nucleotide binding]; other site 926569003361 L27 interface [polypeptide binding]; other site 926569003362 L5 interface [polypeptide binding]; other site 926569003363 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 926569003364 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 926569003365 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 926569003366 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 926569003367 23S rRNA binding site [nucleotide binding]; other site 926569003368 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 926569003369 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 926569003370 SecY translocase; Region: SecY; pfam00344 926569003371 adenylate kinase; Reviewed; Region: adk; PRK00279 926569003372 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 926569003373 AMP-binding site [chemical binding]; other site 926569003374 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 926569003375 methionine aminopeptidase; Provisional; Region: PRK12318 926569003376 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 926569003377 active site 926569003378 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 926569003379 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 926569003380 30S ribosomal protein S13; Region: bact_S13; TIGR03631 926569003381 30S ribosomal protein S11; Validated; Region: PRK05309 926569003382 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 926569003383 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 926569003384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926569003385 RNA binding surface [nucleotide binding]; other site 926569003386 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 926569003387 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 926569003388 alphaNTD homodimer interface [polypeptide binding]; other site 926569003389 alphaNTD - beta interaction site [polypeptide binding]; other site 926569003390 alphaNTD - beta' interaction site [polypeptide binding]; other site 926569003391 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 926569003392 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 926569003393 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 926569003394 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 926569003395 dimerization interface 3.5A [polypeptide binding]; other site 926569003396 active site 926569003397 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 926569003398 23S rRNA interface [nucleotide binding]; other site 926569003399 L3 interface [polypeptide binding]; other site 926569003400 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 926569003401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569003402 Domain of unknown function DUF302; Region: DUF302; cl01364 926569003403 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 926569003404 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 926569003405 putative SAM binding site [chemical binding]; other site 926569003406 putative homodimer interface [polypeptide binding]; other site 926569003407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 926569003408 homodimer interface [polypeptide binding]; other site 926569003409 metal binding site [ion binding]; metal-binding site 926569003410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 926569003411 homodimer interface [polypeptide binding]; other site 926569003412 active site 926569003413 putative chemical substrate binding site [chemical binding]; other site 926569003414 metal binding site [ion binding]; metal-binding site 926569003415 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 926569003416 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 926569003417 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 926569003418 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 926569003419 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 926569003420 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 926569003421 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 926569003422 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569003423 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 926569003424 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569003425 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 926569003426 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569003427 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 926569003428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569003429 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 926569003430 active site 926569003431 catalytic site [active] 926569003432 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569003433 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926569003434 substrate binding site [chemical binding]; other site 926569003435 ATP binding site [chemical binding]; other site 926569003436 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 926569003437 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 926569003438 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 926569003439 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 926569003440 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 926569003441 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 926569003442 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926569003443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926569003444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926569003445 hypothetical protein; Provisional; Region: PRK05170 926569003446 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 926569003447 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 926569003448 RNase E interface [polypeptide binding]; other site 926569003449 trimer interface [polypeptide binding]; other site 926569003450 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 926569003451 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 926569003452 RNase E interface [polypeptide binding]; other site 926569003453 trimer interface [polypeptide binding]; other site 926569003454 active site 926569003455 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 926569003456 putative nucleic acid binding region [nucleotide binding]; other site 926569003457 G-X-X-G motif; other site 926569003458 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 926569003459 RNA binding site [nucleotide binding]; other site 926569003460 domain interface; other site 926569003461 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 926569003462 16S/18S rRNA binding site [nucleotide binding]; other site 926569003463 S13e-L30e interaction site [polypeptide binding]; other site 926569003464 25S rRNA binding site [nucleotide binding]; other site 926569003465 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 926569003466 putative active site [active] 926569003467 nucleotide binding site [chemical binding]; other site 926569003468 nudix motif; other site 926569003469 putative metal binding site [ion binding]; other site 926569003470 prolyl-tRNA synthetase; Provisional; Region: PRK08661 926569003471 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 926569003472 dimer interface [polypeptide binding]; other site 926569003473 motif 1; other site 926569003474 active site 926569003475 motif 2; other site 926569003476 motif 3; other site 926569003477 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 926569003478 anticodon binding site; other site 926569003479 zinc-binding site [ion binding]; other site 926569003480 DHH family; Region: DHH; pfam01368 926569003481 FOG: CBS domain [General function prediction only]; Region: COG0517 926569003482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 926569003483 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 926569003484 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 926569003485 active site 926569003486 NTP binding site [chemical binding]; other site 926569003487 metal binding triad [ion binding]; metal-binding site 926569003488 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 926569003489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926569003490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569003491 Coenzyme A binding pocket [chemical binding]; other site 926569003492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926569003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569003494 S-adenosylmethionine binding site [chemical binding]; other site 926569003495 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 926569003496 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 926569003497 HIGH motif; other site 926569003498 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926569003499 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926569003500 active site 926569003501 KMSKS motif; other site 926569003502 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 926569003503 tRNA binding surface [nucleotide binding]; other site 926569003504 AAA domain; Region: AAA_30; pfam13604 926569003505 AAA domain; Region: AAA_11; pfam13086 926569003506 AAA domain; Region: AAA_12; pfam13087 926569003507 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 926569003508 Family description; Region: UvrD_C_2; pfam13538 926569003509 Creatinine amidohydrolase; Region: Creatininase; pfam02633 926569003510 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 926569003511 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 926569003512 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 926569003513 active site 926569003514 substrate binding site [chemical binding]; other site 926569003515 ATP binding site [chemical binding]; other site 926569003516 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 926569003517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569003518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569003519 Walker A/P-loop; other site 926569003520 ATP binding site [chemical binding]; other site 926569003521 Q-loop/lid; other site 926569003522 ABC transporter signature motif; other site 926569003523 Walker B; other site 926569003524 D-loop; other site 926569003525 H-loop/switch region; other site 926569003526 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 926569003527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569003528 Walker A/P-loop; other site 926569003529 ATP binding site [chemical binding]; other site 926569003530 Q-loop/lid; other site 926569003531 ABC transporter signature motif; other site 926569003532 Walker B; other site 926569003533 D-loop; other site 926569003534 H-loop/switch region; other site 926569003535 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 926569003536 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 926569003537 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926569003538 metal ion-dependent adhesion site (MIDAS); other site 926569003539 EamA-like transporter family; Region: EamA; pfam00892 926569003540 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 926569003541 EamA-like transporter family; Region: EamA; pfam00892 926569003542 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 926569003543 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926569003544 aspartate kinase; Provisional; Region: PRK06291 926569003545 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 926569003546 putative catalytic residues [active] 926569003547 nucleotide binding site [chemical binding]; other site 926569003548 aspartate binding site [chemical binding]; other site 926569003549 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 926569003550 dimer interface [polypeptide binding]; other site 926569003551 putative threonine allosteric regulatory site; other site 926569003552 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 926569003553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569003554 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569003555 Walker A/P-loop; other site 926569003556 ATP binding site [chemical binding]; other site 926569003557 Q-loop/lid; other site 926569003558 ABC transporter signature motif; other site 926569003559 Walker B; other site 926569003560 D-loop; other site 926569003561 H-loop/switch region; other site 926569003562 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 926569003563 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569003564 Walker A/P-loop; other site 926569003565 ATP binding site [chemical binding]; other site 926569003566 Q-loop/lid; other site 926569003567 ABC transporter signature motif; other site 926569003568 Walker B; other site 926569003569 D-loop; other site 926569003570 H-loop/switch region; other site 926569003571 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 926569003572 Predicted membrane protein [Function unknown]; Region: COG4684 926569003573 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 926569003574 cytidylate kinase; Provisional; Region: cmk; PRK00023 926569003575 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 926569003576 CMP-binding site; other site 926569003577 The sites determining sugar specificity; other site 926569003578 PAS domain; Region: PAS_9; pfam13426 926569003579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003580 putative active site [active] 926569003581 heme pocket [chemical binding]; other site 926569003582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003583 PAS domain; Region: PAS_9; pfam13426 926569003584 putative active site [active] 926569003585 heme pocket [chemical binding]; other site 926569003586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003587 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569003588 putative active site [active] 926569003589 heme pocket [chemical binding]; other site 926569003590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003591 dimer interface [polypeptide binding]; other site 926569003592 phosphorylation site [posttranslational modification] 926569003593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003594 ATP binding site [chemical binding]; other site 926569003595 Mg2+ binding site [ion binding]; other site 926569003596 G-X-G motif; other site 926569003597 Response regulator receiver domain; Region: Response_reg; pfam00072 926569003598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003599 active site 926569003600 phosphorylation site [posttranslational modification] 926569003601 intermolecular recognition site; other site 926569003602 dimerization interface [polypeptide binding]; other site 926569003603 Peptidase family C69; Region: Peptidase_C69; cl17793 926569003604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569003605 dimerization interface [polypeptide binding]; other site 926569003606 GAF domain; Region: GAF_3; pfam13492 926569003607 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003608 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569003609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003610 dimer interface [polypeptide binding]; other site 926569003611 phosphorylation site [posttranslational modification] 926569003612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003613 ATP binding site [chemical binding]; other site 926569003614 Mg2+ binding site [ion binding]; other site 926569003615 G-X-G motif; other site 926569003616 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 926569003617 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 926569003618 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 926569003619 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 926569003620 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 926569003621 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 926569003622 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 926569003623 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 926569003624 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 926569003625 DNA binding site [nucleotide binding] 926569003626 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 926569003627 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 926569003628 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 926569003629 CAP-like domain; other site 926569003630 active site 926569003631 primary dimer interface [polypeptide binding]; other site 926569003632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926569003633 SnoaL-like domain; Region: SnoaL_2; pfam12680 926569003634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 926569003635 Zn2+ binding site [ion binding]; other site 926569003636 Mg2+ binding site [ion binding]; other site 926569003637 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926569003638 putative active site [active] 926569003639 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 926569003640 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 926569003641 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 926569003642 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 926569003643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926569003644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569003645 dimer interface [polypeptide binding]; other site 926569003646 conserved gate region; other site 926569003647 putative PBP binding loops; other site 926569003648 ABC-ATPase subunit interface; other site 926569003649 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 926569003650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 926569003651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569003652 dimer interface [polypeptide binding]; other site 926569003653 conserved gate region; other site 926569003654 putative PBP binding loops; other site 926569003655 ABC-ATPase subunit interface; other site 926569003656 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 926569003657 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569003658 Walker A/P-loop; other site 926569003659 ATP binding site [chemical binding]; other site 926569003660 Q-loop/lid; other site 926569003661 ABC transporter signature motif; other site 926569003662 Walker B; other site 926569003663 D-loop; other site 926569003664 H-loop/switch region; other site 926569003665 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569003666 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 926569003667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926569003668 Walker A/P-loop; other site 926569003669 ATP binding site [chemical binding]; other site 926569003670 Q-loop/lid; other site 926569003671 ABC transporter signature motif; other site 926569003672 Walker B; other site 926569003673 D-loop; other site 926569003674 H-loop/switch region; other site 926569003675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 926569003676 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569003677 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569003678 ligand binding site [chemical binding]; other site 926569003679 flexible hinge region; other site 926569003680 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569003681 Double zinc ribbon; Region: DZR; pfam12773 926569003682 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569003683 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 926569003684 cyclase homology domain; Region: CHD; cd07302 926569003685 nucleotidyl binding site; other site 926569003686 metal binding site [ion binding]; metal-binding site 926569003687 dimer interface [polypeptide binding]; other site 926569003688 Predicted ATPase [General function prediction only]; Region: COG3899 926569003689 AAA ATPase domain; Region: AAA_16; pfam13191 926569003690 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569003691 MarR family; Region: MarR_2; cl17246 926569003692 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569003693 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569003694 nucleotide binding site [chemical binding]; other site 926569003695 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 926569003696 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 926569003697 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 926569003698 putative active site [active] 926569003699 catalytic site [active] 926569003700 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 926569003701 putative ligand binding site [chemical binding]; other site 926569003702 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 926569003703 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 926569003704 active site 926569003705 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 926569003706 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 926569003707 hinge; other site 926569003708 active site 926569003709 flagellar capping protein; Provisional; Region: PRK12765 926569003710 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569003711 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569003712 nucleotide binding site [chemical binding]; other site 926569003713 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 926569003714 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 926569003715 NAD binding site [chemical binding]; other site 926569003716 sugar binding site [chemical binding]; other site 926569003717 divalent metal binding site [ion binding]; other site 926569003718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569003719 dimer interface [polypeptide binding]; other site 926569003720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569003721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569003722 DNA binding site [nucleotide binding] 926569003723 domain linker motif; other site 926569003724 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926569003725 dimerization interface [polypeptide binding]; other site 926569003726 ligand binding site [chemical binding]; other site 926569003727 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569003728 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569003729 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569003730 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 926569003731 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 926569003732 Metal-binding active site; metal-binding site 926569003733 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 926569003734 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 926569003735 conserved cys residue [active] 926569003736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569003737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569003738 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926569003739 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 926569003740 beta-galactosidase; Region: BGL; TIGR03356 926569003741 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 926569003742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569003743 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 926569003744 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 926569003745 nudix motif; other site 926569003746 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 926569003747 trimer interface [polypeptide binding]; other site 926569003748 active site 926569003749 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 926569003750 putative active site [active] 926569003751 putative metal binding site [ion binding]; other site 926569003752 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 926569003753 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 926569003754 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 926569003755 Formiminotransferase domain; Region: FTCD; pfam02971 926569003756 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 926569003757 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 926569003758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569003759 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 926569003760 CHASE4 domain; Region: CHASE4; cl01308 926569003761 GAF domain; Region: GAF_3; pfam13492 926569003762 GAF domain; Region: GAF_2; pfam13185 926569003763 GAF domain; Region: GAF; cl17456 926569003764 PAS domain S-box; Region: sensory_box; TIGR00229 926569003765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003766 putative active site [active] 926569003767 heme pocket [chemical binding]; other site 926569003768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003769 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003771 dimer interface [polypeptide binding]; other site 926569003772 phosphorylation site [posttranslational modification] 926569003773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003774 ATP binding site [chemical binding]; other site 926569003775 Mg2+ binding site [ion binding]; other site 926569003776 G-X-G motif; other site 926569003777 Response regulator receiver domain; Region: Response_reg; pfam00072 926569003778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003779 active site 926569003780 phosphorylation site [posttranslational modification] 926569003781 intermolecular recognition site; other site 926569003782 dimerization interface [polypeptide binding]; other site 926569003783 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 926569003784 putative binding surface; other site 926569003785 active site 926569003786 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 926569003787 putative active site [active] 926569003788 Protein of unknown function (DUF554); Region: DUF554; pfam04474 926569003789 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 926569003790 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926569003791 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 926569003792 peptide binding site [polypeptide binding]; other site 926569003793 dimer interface [polypeptide binding]; other site 926569003794 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 926569003795 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 926569003796 active site 926569003797 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 926569003798 putative deacylase active site [active] 926569003799 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 926569003800 hypothetical protein; Reviewed; Region: PRK09588 926569003801 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 926569003802 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569003803 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569003804 phosphopeptide binding site; other site 926569003805 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569003806 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569003807 phosphopeptide binding site; other site 926569003808 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 926569003809 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 926569003810 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 926569003811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 926569003812 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 926569003813 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 926569003814 catalytic residues [active] 926569003815 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 926569003816 active site 926569003817 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 926569003818 putative substrate binding site [chemical binding]; other site 926569003819 active site 926569003820 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569003822 dimer interface [polypeptide binding]; other site 926569003823 conserved gate region; other site 926569003824 putative PBP binding loops; other site 926569003825 ABC-ATPase subunit interface; other site 926569003826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569003828 ABC-ATPase subunit interface; other site 926569003829 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569003830 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569003831 Predicted transcriptional regulator [Transcription]; Region: COG4189 926569003832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569003833 putative DNA binding site [nucleotide binding]; other site 926569003834 dimerization interface [polypeptide binding]; other site 926569003835 putative Zn2+ binding site [ion binding]; other site 926569003836 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 926569003837 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926569003838 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926569003839 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926569003840 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926569003841 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 926569003842 putative active site [active] 926569003843 catalytic triad [active] 926569003844 putative dimer interface [polypeptide binding]; other site 926569003845 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 926569003846 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926569003847 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569003848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569003849 Histidine kinase; Region: HisKA_3; pfam07730 926569003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003851 ATP binding site [chemical binding]; other site 926569003852 Mg2+ binding site [ion binding]; other site 926569003853 G-X-G motif; other site 926569003854 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926569003855 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 926569003856 active site 926569003857 ADP/pyrophosphate binding site [chemical binding]; other site 926569003858 dimerization interface [polypeptide binding]; other site 926569003859 allosteric effector site; other site 926569003860 fructose-1,6-bisphosphate binding site; other site 926569003861 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 926569003862 intersubunit interface [polypeptide binding]; other site 926569003863 active site 926569003864 zinc binding site [ion binding]; other site 926569003865 Na+ binding site [ion binding]; other site 926569003866 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 926569003867 nudix motif; other site 926569003868 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 926569003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569003870 S-adenosylmethionine binding site [chemical binding]; other site 926569003871 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 926569003872 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 926569003873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569003874 binding surface 926569003875 TPR motif; other site 926569003876 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 926569003877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569003878 Walker A motif; other site 926569003879 ATP binding site [chemical binding]; other site 926569003880 Walker B motif; other site 926569003881 arginine finger; other site 926569003882 Predicted membrane protein [Function unknown]; Region: COG2246 926569003883 GtrA-like protein; Region: GtrA; pfam04138 926569003884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569003885 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 926569003886 NAD binding site [chemical binding]; other site 926569003887 putative substrate binding site 2 [chemical binding]; other site 926569003888 putative substrate binding site 1 [chemical binding]; other site 926569003889 active site 926569003890 Domain of unknown function (DUF348); Region: DUF348; pfam03990 926569003891 G5 domain; Region: G5; pfam07501 926569003892 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 926569003893 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 926569003894 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 926569003895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926569003896 RNA binding surface [nucleotide binding]; other site 926569003897 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 926569003898 active site 926569003899 putative phosphate acyltransferase; Provisional; Region: PRK05331 926569003900 Response regulator receiver domain; Region: Response_reg; pfam00072 926569003901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003902 active site 926569003903 phosphorylation site [posttranslational modification] 926569003904 intermolecular recognition site; other site 926569003905 dimerization interface [polypeptide binding]; other site 926569003906 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003907 GAF domain; Region: GAF_3; pfam13492 926569003908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003909 dimer interface [polypeptide binding]; other site 926569003910 phosphorylation site [posttranslational modification] 926569003911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003912 ATP binding site [chemical binding]; other site 926569003913 Mg2+ binding site [ion binding]; other site 926569003914 G-X-G motif; other site 926569003915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569003916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003917 active site 926569003918 phosphorylation site [posttranslational modification] 926569003919 intermolecular recognition site; other site 926569003920 dimerization interface [polypeptide binding]; other site 926569003921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569003922 DNA binding site [nucleotide binding] 926569003923 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926569003924 threonine synthase; Validated; Region: PRK06260 926569003925 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 926569003926 homodimer interface [polypeptide binding]; other site 926569003927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569003928 catalytic residue [active] 926569003929 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569003930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003931 active site 926569003932 phosphorylation site [posttranslational modification] 926569003933 intermolecular recognition site; other site 926569003934 dimerization interface [polypeptide binding]; other site 926569003935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003936 putative active site [active] 926569003937 heme pocket [chemical binding]; other site 926569003938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003939 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003940 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003941 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003942 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003943 GAF domain; Region: GAF; pfam01590 926569003944 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003945 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569003947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569003948 dimer interface [polypeptide binding]; other site 926569003949 phosphorylation site [posttranslational modification] 926569003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569003951 ATP binding site [chemical binding]; other site 926569003952 Mg2+ binding site [ion binding]; other site 926569003953 G-X-G motif; other site 926569003954 Response regulator receiver domain; Region: Response_reg; pfam00072 926569003955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003956 active site 926569003957 phosphorylation site [posttranslational modification] 926569003958 intermolecular recognition site; other site 926569003959 dimerization interface [polypeptide binding]; other site 926569003960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003962 active site 926569003963 phosphorylation site [posttranslational modification] 926569003964 intermolecular recognition site; other site 926569003965 dimerization interface [polypeptide binding]; other site 926569003966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926569003967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569003968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569003969 dimerization interface [polypeptide binding]; other site 926569003970 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003971 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003972 GAF domain; Region: GAF; cl17456 926569003973 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003974 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003976 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003977 GAF domain; Region: GAF; pfam01590 926569003978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569003979 dimerization interface [polypeptide binding]; other site 926569003980 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003981 GAF domain; Region: GAF; pfam01590 926569003982 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003983 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003984 PAS fold; Region: PAS_4; pfam08448 926569003985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569003986 putative active site [active] 926569003987 heme pocket [chemical binding]; other site 926569003988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926569003989 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003990 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003991 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569003992 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569003993 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569003994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569003995 active site 926569003996 phosphorylation site [posttranslational modification] 926569003997 intermolecular recognition site; other site 926569003998 dimerization interface [polypeptide binding]; other site 926569003999 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569004000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004001 active site 926569004002 phosphorylation site [posttranslational modification] 926569004003 intermolecular recognition site; other site 926569004004 dimerization interface [polypeptide binding]; other site 926569004005 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 926569004006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569004007 active site 926569004008 motif I; other site 926569004009 motif II; other site 926569004010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569004011 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 926569004012 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 926569004013 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926569004014 active site 926569004015 metal binding site [ion binding]; metal-binding site 926569004016 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 926569004017 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 926569004018 Flavoprotein; Region: Flavoprotein; pfam02441 926569004019 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 926569004020 pantothenate kinase; Reviewed; Region: PRK13318 926569004021 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 926569004022 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 926569004023 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 926569004024 FAD binding site [chemical binding]; other site 926569004025 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 926569004026 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 926569004027 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 926569004028 substrate binding pocket [chemical binding]; other site 926569004029 dimer interface [polypeptide binding]; other site 926569004030 inhibitor binding site; inhibition site 926569004031 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 926569004032 B12 binding site [chemical binding]; other site 926569004033 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 926569004034 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 926569004035 4Fe-4S binding domain; Region: Fer4; pfam00037 926569004036 selenocysteine synthase; Provisional; Region: PRK04311 926569004037 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 926569004038 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 926569004039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569004040 catalytic residue [active] 926569004041 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 926569004042 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 926569004043 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 926569004044 active site 926569004045 UGMP family protein; Validated; Region: PRK09604 926569004046 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926569004047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569004048 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926569004049 Putative zinc-finger; Region: zf-HC2; pfam13490 926569004050 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 926569004051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926569004052 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 926569004053 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 926569004054 catalytic residues [active] 926569004055 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 926569004056 H+ Antiporter protein; Region: 2A0121; TIGR00900 926569004057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004058 putative substrate translocation pore; other site 926569004059 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569004060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569004061 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569004062 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 926569004063 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569004064 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569004065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569004066 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569004067 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569004068 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 926569004069 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 926569004070 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 926569004071 aconitate hydratase; Validated; Region: PRK09277 926569004072 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 926569004073 substrate binding site [chemical binding]; other site 926569004074 ligand binding site [chemical binding]; other site 926569004075 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 926569004076 substrate binding site [chemical binding]; other site 926569004077 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 926569004078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926569004079 substrate binding pocket [chemical binding]; other site 926569004080 membrane-bound complex binding site; other site 926569004081 hinge residues; other site 926569004082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 926569004083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569004084 dimer interface [polypeptide binding]; other site 926569004085 conserved gate region; other site 926569004086 putative PBP binding loops; other site 926569004087 ABC-ATPase subunit interface; other site 926569004088 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 926569004089 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 926569004090 Walker A/P-loop; other site 926569004091 ATP binding site [chemical binding]; other site 926569004092 Q-loop/lid; other site 926569004093 ABC transporter signature motif; other site 926569004094 Walker B; other site 926569004095 D-loop; other site 926569004096 H-loop/switch region; other site 926569004097 type I citrate synthase; Reviewed; Region: PRK09569 926569004098 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 926569004099 oxalacetate binding site [chemical binding]; other site 926569004100 citrylCoA binding site [chemical binding]; other site 926569004101 coenzyme A binding site [chemical binding]; other site 926569004102 catalytic triad [active] 926569004103 gamma-glutamyl kinase; Provisional; Region: PRK05429 926569004104 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 926569004105 nucleotide binding site [chemical binding]; other site 926569004106 homotetrameric interface [polypeptide binding]; other site 926569004107 putative phosphate binding site [ion binding]; other site 926569004108 putative allosteric binding site; other site 926569004109 PUA domain; Region: PUA; pfam01472 926569004110 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 926569004111 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 926569004112 putative catalytic cysteine [active] 926569004113 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 926569004114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569004115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569004116 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 926569004117 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 926569004118 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 926569004119 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 926569004120 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 926569004121 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 926569004122 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 926569004123 Predicted transcriptional regulator [Transcription]; Region: COG2378 926569004124 WYL domain; Region: WYL; pfam13280 926569004125 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 926569004126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926569004127 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 926569004128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004129 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 926569004130 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 926569004131 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 926569004132 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 926569004133 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 926569004134 YCII-related domain; Region: YCII; cl00999 926569004135 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 926569004136 acetyl-lysine deacetylase; Provisional; Region: PRK04443 926569004137 metal binding site [ion binding]; metal-binding site 926569004138 putative dimer interface [polypeptide binding]; other site 926569004139 acetylornithine aminotransferase; Provisional; Region: PRK02627 926569004140 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926569004141 inhibitor-cofactor binding pocket; inhibition site 926569004142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569004143 catalytic residue [active] 926569004144 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 926569004145 putative nucleotide binding site [chemical binding]; other site 926569004146 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 926569004147 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 926569004148 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926569004149 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 926569004150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926569004151 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 926569004152 argininosuccinate lyase; Provisional; Region: PRK00855 926569004153 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 926569004154 active sites [active] 926569004155 tetramer interface [polypeptide binding]; other site 926569004156 argininosuccinate synthase; Provisional; Region: PRK13820 926569004157 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 926569004158 ANP binding site [chemical binding]; other site 926569004159 Substrate Binding Site II [chemical binding]; other site 926569004160 Substrate Binding Site I [chemical binding]; other site 926569004161 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 926569004162 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 926569004163 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926569004164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569004165 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569004166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569004167 GAF domain; Region: GAF_3; pfam13492 926569004168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569004169 Histidine kinase; Region: HisKA_3; pfam07730 926569004170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569004171 ATP binding site [chemical binding]; other site 926569004172 Mg2+ binding site [ion binding]; other site 926569004173 G-X-G motif; other site 926569004174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569004176 active site 926569004177 phosphorylation site [posttranslational modification] 926569004178 intermolecular recognition site; other site 926569004179 dimerization interface [polypeptide binding]; other site 926569004180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569004181 dimerization interface [polypeptide binding]; other site 926569004182 DNA binding residues [nucleotide binding] 926569004183 FOG: CBS domain [General function prediction only]; Region: COG0517 926569004184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 926569004185 FOG: CBS domain [General function prediction only]; Region: COG0517 926569004186 FOG: CBS domain [General function prediction only]; Region: COG0517 926569004187 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 926569004188 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 926569004189 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 926569004190 putative dimer interface [polypeptide binding]; other site 926569004191 [2Fe-2S] cluster binding site [ion binding]; other site 926569004192 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 926569004193 dimer interface [polypeptide binding]; other site 926569004194 [2Fe-2S] cluster binding site [ion binding]; other site 926569004195 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 926569004196 SLBB domain; Region: SLBB; pfam10531 926569004197 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 926569004198 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 926569004199 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569004200 catalytic loop [active] 926569004201 iron binding site [ion binding]; other site 926569004202 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 926569004203 4Fe-4S binding domain; Region: Fer4; pfam00037 926569004204 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 926569004205 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 926569004206 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 926569004207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926569004208 Ligand Binding Site [chemical binding]; other site 926569004209 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926569004210 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926569004211 metal-binding site [ion binding] 926569004212 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 926569004213 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569004214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569004215 motif II; other site 926569004216 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926569004217 metal-binding site [ion binding] 926569004218 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 926569004219 putative homodimer interface [polypeptide binding]; other site 926569004220 putative homotetramer interface [polypeptide binding]; other site 926569004221 allosteric switch controlling residues; other site 926569004222 putative metal binding site [ion binding]; other site 926569004223 putative homodimer-homodimer interface [polypeptide binding]; other site 926569004224 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 926569004225 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 926569004226 DNA binding site [nucleotide binding] 926569004227 catalytic residue [active] 926569004228 H2TH interface [polypeptide binding]; other site 926569004229 putative catalytic residues [active] 926569004230 turnover-facilitating residue; other site 926569004231 intercalation triad [nucleotide binding]; other site 926569004232 8OG recognition residue [nucleotide binding]; other site 926569004233 putative reading head residues; other site 926569004234 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 926569004235 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 926569004236 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 926569004237 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 926569004238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569004239 active site 926569004240 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 926569004241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569004242 Coenzyme A binding pocket [chemical binding]; other site 926569004243 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 926569004244 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 926569004245 dimer interface [polypeptide binding]; other site 926569004246 anticodon binding site; other site 926569004247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 926569004248 motif 1; other site 926569004249 dimer interface [polypeptide binding]; other site 926569004250 active site 926569004251 motif 2; other site 926569004252 GAD domain; Region: GAD; pfam02938 926569004253 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 926569004254 motif 3; other site 926569004255 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 926569004256 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 926569004257 Walker A; other site 926569004258 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 926569004259 Switch II region; other site 926569004260 G4 box; other site 926569004261 G5 box; other site 926569004262 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 926569004263 B12 binding site [chemical binding]; other site 926569004264 cobalt ligand [ion binding]; other site 926569004265 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926569004266 metal binding site 2 [ion binding]; metal-binding site 926569004267 putative DNA binding helix; other site 926569004268 metal binding site 1 [ion binding]; metal-binding site 926569004269 dimer interface [polypeptide binding]; other site 926569004270 structural Zn2+ binding site [ion binding]; other site 926569004271 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 926569004272 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 926569004273 PDGLE domain; Region: PDGLE; cl07986 926569004274 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 926569004275 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569004276 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569004277 Walker A/P-loop; other site 926569004278 ATP binding site [chemical binding]; other site 926569004279 Q-loop/lid; other site 926569004280 ABC transporter signature motif; other site 926569004281 Walker B; other site 926569004282 D-loop; other site 926569004283 H-loop/switch region; other site 926569004284 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926569004285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569004286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569004287 catalytic residue [active] 926569004288 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 926569004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004290 putative substrate translocation pore; other site 926569004291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569004292 Radical SAM superfamily; Region: Radical_SAM; pfam04055 926569004293 FeS/SAM binding site; other site 926569004294 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926569004295 Helix-hairpin-helix motif; Region: HHH; pfam00633 926569004296 spermidine synthase; Provisional; Region: PRK00811 926569004297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569004298 S-adenosylmethionine binding site [chemical binding]; other site 926569004299 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 926569004300 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 926569004301 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 926569004302 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926569004303 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569004304 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 926569004305 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 926569004306 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 926569004307 Walker A/P-loop; other site 926569004308 ATP binding site [chemical binding]; other site 926569004309 Q-loop/lid; other site 926569004310 ABC transporter signature motif; other site 926569004311 Walker B; other site 926569004312 D-loop; other site 926569004313 H-loop/switch region; other site 926569004314 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 926569004315 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 926569004316 Walker A/P-loop; other site 926569004317 ATP binding site [chemical binding]; other site 926569004318 Q-loop/lid; other site 926569004319 ABC transporter signature motif; other site 926569004320 Walker B; other site 926569004321 D-loop; other site 926569004322 H-loop/switch region; other site 926569004323 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 926569004324 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 926569004325 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 926569004326 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 926569004327 TM-ABC transporter signature motif; other site 926569004328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569004329 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 926569004330 TM-ABC transporter signature motif; other site 926569004331 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 926569004332 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 926569004333 putative ligand binding site [chemical binding]; other site 926569004334 NAD-dependent deacetylase; Provisional; Region: PRK00481 926569004335 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 926569004336 NAD+ binding site [chemical binding]; other site 926569004337 substrate binding site [chemical binding]; other site 926569004338 Zn binding site [ion binding]; other site 926569004339 Response regulator receiver domain; Region: Response_reg; pfam00072 926569004340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004341 active site 926569004342 phosphorylation site [posttranslational modification] 926569004343 intermolecular recognition site; other site 926569004344 dimerization interface [polypeptide binding]; other site 926569004345 AAA domain; Region: AAA_31; pfam13614 926569004346 Predicted integral membrane protein [Function unknown]; Region: COG0392 926569004347 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926569004348 C-terminal peptidase (prc); Region: prc; TIGR00225 926569004349 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926569004350 protein binding site [polypeptide binding]; other site 926569004351 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926569004352 Catalytic dyad [active] 926569004353 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 926569004354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569004355 motif II; other site 926569004356 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 926569004357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569004358 ATP binding site [chemical binding]; other site 926569004359 Mg2+ binding site [ion binding]; other site 926569004360 G-X-G motif; other site 926569004361 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 926569004362 ATP binding site [chemical binding]; other site 926569004363 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 926569004364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569004365 NHL repeat; Region: NHL; pfam01436 926569004366 Uncharacterized conserved protein [Function unknown]; Region: COG3391 926569004367 NHL repeat; Region: NHL; pfam01436 926569004368 NHL repeat; Region: NHL; pfam01436 926569004369 NHL repeat; Region: NHL; pfam01436 926569004370 NHL repeat; Region: NHL; pfam01436 926569004371 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 926569004372 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 926569004373 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 926569004374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569004375 active site 926569004376 motif I; other site 926569004377 motif II; other site 926569004378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569004379 Zn2+ binding site [ion binding]; other site 926569004380 Mg2+ binding site [ion binding]; other site 926569004381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569004383 putative substrate translocation pore; other site 926569004384 Predicted methyltransferases [General function prediction only]; Region: COG0313 926569004385 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 926569004386 putative SAM binding site [chemical binding]; other site 926569004387 putative homodimer interface [polypeptide binding]; other site 926569004388 glutamine synthetase, type I; Region: GlnA; TIGR00653 926569004389 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 926569004390 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 926569004391 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 926569004392 metal binding triad; other site 926569004393 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 926569004394 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 926569004395 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 926569004396 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 926569004397 metal binding triad; other site 926569004398 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 926569004399 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 926569004400 thiS-thiF/thiG interaction site; other site 926569004401 PBP superfamily domain; Region: PBP_like_2; cl17296 926569004402 Bacitracin resistance protein BacA; Region: BacA; pfam02673 926569004403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004404 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 926569004405 alanine racemase; Reviewed; Region: alr; PRK00053 926569004406 active site 926569004407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926569004408 dimer interface [polypeptide binding]; other site 926569004409 substrate binding site [chemical binding]; other site 926569004410 catalytic residues [active] 926569004411 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 926569004412 DHH family; Region: DHH; pfam01368 926569004413 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 926569004414 Ligand binding site; other site 926569004415 Putative Catalytic site; other site 926569004416 DXD motif; other site 926569004417 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 926569004418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569004419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569004420 DNA binding residues [nucleotide binding] 926569004421 Putative zinc-finger; Region: zf-HC2; pfam13490 926569004422 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 926569004423 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 926569004424 transmembrane helices; other site 926569004425 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 926569004426 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 926569004427 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 926569004428 active site 926569004429 (T/H)XGH motif; other site 926569004430 GTPase CgtA; Reviewed; Region: obgE; PRK12297 926569004431 GTP1/OBG; Region: GTP1_OBG; pfam01018 926569004432 Obg GTPase; Region: Obg; cd01898 926569004433 G1 box; other site 926569004434 GTP/Mg2+ binding site [chemical binding]; other site 926569004435 Switch I region; other site 926569004436 G2 box; other site 926569004437 G3 box; other site 926569004438 Switch II region; other site 926569004439 G4 box; other site 926569004440 G5 box; other site 926569004441 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 926569004442 Predicted GTPase [General function prediction only]; Region: COG2403 926569004443 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 926569004444 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 926569004445 active site 926569004446 HIGH motif; other site 926569004447 KMSK motif region; other site 926569004448 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 926569004449 tRNA binding surface [nucleotide binding]; other site 926569004450 anticodon binding site; other site 926569004451 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 926569004452 Phosphoglycerate kinase; Region: PGK; pfam00162 926569004453 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 926569004454 substrate binding site [chemical binding]; other site 926569004455 hinge regions; other site 926569004456 ADP binding site [chemical binding]; other site 926569004457 catalytic site [active] 926569004458 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 926569004459 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 926569004460 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926569004461 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 926569004462 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 926569004463 phosphate binding site [ion binding]; other site 926569004464 putative substrate binding pocket [chemical binding]; other site 926569004465 dimer interface [polypeptide binding]; other site 926569004466 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569004467 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569004468 nucleotide binding site [chemical binding]; other site 926569004469 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569004470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926569004471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569004472 catalytic residue [active] 926569004473 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569004474 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569004475 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569004476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569004477 putative active site [active] 926569004478 heme pocket [chemical binding]; other site 926569004479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569004480 dimer interface [polypeptide binding]; other site 926569004481 phosphorylation site [posttranslational modification] 926569004482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569004483 ATP binding site [chemical binding]; other site 926569004484 Mg2+ binding site [ion binding]; other site 926569004485 G-X-G motif; other site 926569004486 CpXC protein; Region: CpXC; pfam14353 926569004487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569004488 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569004489 phosphopeptide binding site; other site 926569004490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569004491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569004492 DNA binding site [nucleotide binding] 926569004493 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 926569004494 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 926569004495 active site 926569004496 ATP binding site [chemical binding]; other site 926569004497 substrate binding site [chemical binding]; other site 926569004498 activation loop (A-loop); other site 926569004499 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926569004500 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 926569004501 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 926569004502 tetramer interface [polypeptide binding]; other site 926569004503 hypothetical protein; Provisional; Region: PRK06815 926569004504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569004505 catalytic residue [active] 926569004506 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 926569004507 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 926569004508 active site 926569004509 catalytic site [active] 926569004510 metal binding site [ion binding]; metal-binding site 926569004511 dimer interface [polypeptide binding]; other site 926569004512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569004513 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569004514 Walker A motif; other site 926569004515 ATP binding site [chemical binding]; other site 926569004516 Walker B motif; other site 926569004517 arginine finger; other site 926569004518 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 926569004519 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 926569004520 dimer interface [polypeptide binding]; other site 926569004521 active site 926569004522 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 926569004523 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 926569004524 Substrate-binding site [chemical binding]; other site 926569004525 Substrate specificity [chemical binding]; other site 926569004526 Protein of unknown function (DUF970); Region: DUF970; cl17525 926569004527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569004529 putative substrate translocation pore; other site 926569004530 TSCPD domain; Region: TSCPD; cl14834 926569004531 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 926569004532 DNA photolyase; Region: DNA_photolyase; pfam00875 926569004533 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 926569004534 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 926569004535 iron-sulfur cluster [ion binding]; other site 926569004536 [2Fe-2S] cluster binding site [ion binding]; other site 926569004537 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926569004538 hydrophobic ligand binding site; other site 926569004539 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 926569004540 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 926569004541 active site lid residues [active] 926569004542 substrate binding pocket [chemical binding]; other site 926569004543 catalytic residues [active] 926569004544 substrate-Mg2+ binding site; other site 926569004545 aspartate-rich region 1; other site 926569004546 aspartate-rich region 2; other site 926569004547 phytoene desaturase; Region: crtI_fam; TIGR02734 926569004548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569004549 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926569004550 hydrophobic ligand binding site; other site 926569004551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569004553 putative substrate translocation pore; other site 926569004554 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926569004555 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 926569004556 DNA binding residues [nucleotide binding] 926569004557 B12 binding domain; Region: B12-binding_2; pfam02607 926569004558 B12 binding domain; Region: B12-binding; pfam02310 926569004559 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926569004560 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 926569004561 DNA binding residues [nucleotide binding] 926569004562 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 926569004563 B12 binding domain; Region: B12-binding_2; pfam02607 926569004564 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 926569004565 B12 binding site [chemical binding]; other site 926569004566 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569004567 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569004568 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569004569 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 926569004570 active site 926569004571 catalytic site [active] 926569004572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569004573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004574 active site 926569004575 phosphorylation site [posttranslational modification] 926569004576 intermolecular recognition site; other site 926569004577 dimerization interface [polypeptide binding]; other site 926569004578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569004579 DNA binding site [nucleotide binding] 926569004580 Isochorismatase family; Region: Isochorismatase; pfam00857 926569004581 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 926569004582 catalytic triad [active] 926569004583 conserved cis-peptide bond; other site 926569004584 Response regulator receiver domain; Region: Response_reg; pfam00072 926569004585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004586 active site 926569004587 phosphorylation site [posttranslational modification] 926569004588 intermolecular recognition site; other site 926569004589 dimerization interface [polypeptide binding]; other site 926569004590 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 926569004591 putative binding surface; other site 926569004592 active site 926569004593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004595 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 926569004596 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 926569004597 intersubunit interface [polypeptide binding]; other site 926569004598 active site 926569004599 Zn2+ binding site [ion binding]; other site 926569004600 ribulokinase; Provisional; Region: PRK04123 926569004601 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 926569004602 N- and C-terminal domain interface [polypeptide binding]; other site 926569004603 active site 926569004604 MgATP binding site [chemical binding]; other site 926569004605 catalytic site [active] 926569004606 metal binding site [ion binding]; metal-binding site 926569004607 carbohydrate binding site [chemical binding]; other site 926569004608 homodimer interface [polypeptide binding]; other site 926569004609 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 926569004610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 926569004611 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 926569004612 active site 926569004613 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 926569004614 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 926569004615 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926569004616 substrate binding site [chemical binding]; other site 926569004617 trimer interface [polypeptide binding]; other site 926569004618 Mn binding site [ion binding]; other site 926569004619 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569004620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569004621 DNA binding site [nucleotide binding] 926569004622 domain linker motif; other site 926569004623 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926569004624 dimerization interface [polypeptide binding]; other site 926569004625 ligand binding site [chemical binding]; other site 926569004626 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 926569004627 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 926569004628 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926569004629 hypothetical protein; Validated; Region: PRK00110 926569004630 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 926569004631 active site 926569004632 putative DNA-binding cleft [nucleotide binding]; other site 926569004633 dimer interface [polypeptide binding]; other site 926569004634 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926569004635 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 926569004636 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926569004637 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 926569004638 RuvA N terminal domain; Region: RuvA_N; pfam01330 926569004639 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 926569004640 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 926569004641 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926569004642 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 926569004643 beta subunit interaction interface [polypeptide binding]; other site 926569004644 Walker A motif; other site 926569004645 ATP binding site [chemical binding]; other site 926569004646 Walker B motif; other site 926569004647 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926569004648 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 926569004649 core domain interface [polypeptide binding]; other site 926569004650 delta subunit interface [polypeptide binding]; other site 926569004651 epsilon subunit interface [polypeptide binding]; other site 926569004652 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 926569004653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926569004654 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 926569004655 alpha subunit interaction interface [polypeptide binding]; other site 926569004656 Walker A motif; other site 926569004657 ATP binding site [chemical binding]; other site 926569004658 Walker B motif; other site 926569004659 inhibitor binding site; inhibition site 926569004660 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926569004661 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 926569004662 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 926569004663 gamma subunit interface [polypeptide binding]; other site 926569004664 epsilon subunit interface [polypeptide binding]; other site 926569004665 LBP interface [polypeptide binding]; other site 926569004666 rod shape-determining protein MreB; Provisional; Region: PRK13930 926569004667 MreB and similar proteins; Region: MreB_like; cd10225 926569004668 nucleotide binding site [chemical binding]; other site 926569004669 Mg binding site [ion binding]; other site 926569004670 putative protofilament interaction site [polypeptide binding]; other site 926569004671 RodZ interaction site [polypeptide binding]; other site 926569004672 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 926569004673 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 926569004674 CoA binding domain; Region: CoA_binding; pfam02629 926569004675 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 926569004676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926569004677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569004678 Coenzyme A binding pocket [chemical binding]; other site 926569004679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569004680 non-specific DNA binding site [nucleotide binding]; other site 926569004681 salt bridge; other site 926569004682 sequence-specific DNA binding site [nucleotide binding]; other site 926569004683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569004684 non-specific DNA binding site [nucleotide binding]; other site 926569004685 salt bridge; other site 926569004686 sequence-specific DNA binding site [nucleotide binding]; other site 926569004687 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 926569004688 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 926569004689 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 926569004690 ATP binding site [chemical binding]; other site 926569004691 Walker A motif; other site 926569004692 hexamer interface [polypeptide binding]; other site 926569004693 Walker B motif; other site 926569004694 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569004695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004696 active site 926569004697 phosphorylation site [posttranslational modification] 926569004698 intermolecular recognition site; other site 926569004699 dimerization interface [polypeptide binding]; other site 926569004700 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569004701 DNA binding site [nucleotide binding] 926569004702 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569004703 GAF domain; Region: GAF_3; pfam13492 926569004704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569004705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569004706 dimer interface [polypeptide binding]; other site 926569004707 phosphorylation site [posttranslational modification] 926569004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569004709 ATP binding site [chemical binding]; other site 926569004710 Mg2+ binding site [ion binding]; other site 926569004711 G-X-G motif; other site 926569004712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569004713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569004714 ATP binding site [chemical binding]; other site 926569004715 Mg2+ binding site [ion binding]; other site 926569004716 G-X-G motif; other site 926569004717 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004718 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569004719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569004720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569004721 dimer interface [polypeptide binding]; other site 926569004722 phosphorylation site [posttranslational modification] 926569004723 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 926569004724 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 926569004725 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 926569004726 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 926569004727 active site 926569004728 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 926569004729 ParB-like nuclease domain; Region: ParB; smart00470 926569004730 KorB domain; Region: KorB; pfam08535 926569004731 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926569004732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569004733 P-loop; other site 926569004734 Magnesium ion binding site [ion binding]; other site 926569004735 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569004736 Magnesium ion binding site [ion binding]; other site 926569004737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569004738 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 926569004739 substrate binding site [chemical binding]; other site 926569004740 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569004741 ATP binding site [chemical binding]; other site 926569004742 Double zinc ribbon; Region: DZR; pfam12773 926569004743 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569004744 hypothetical protein; Reviewed; Region: PRK00024 926569004745 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926569004746 MPN+ (JAMM) motif; other site 926569004747 Zinc-binding site [ion binding]; other site 926569004748 Nuclease-related domain; Region: NERD; pfam08378 926569004749 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 926569004750 Family description; Region: UvrD_C_2; pfam13538 926569004751 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 926569004752 elongation factor G; Reviewed; Region: PRK12740 926569004753 G1 box; other site 926569004754 putative GEF interaction site [polypeptide binding]; other site 926569004755 GTP/Mg2+ binding site [chemical binding]; other site 926569004756 Switch I region; other site 926569004757 G2 box; other site 926569004758 G3 box; other site 926569004759 Switch II region; other site 926569004760 G4 box; other site 926569004761 G5 box; other site 926569004762 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 926569004763 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 926569004764 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 926569004765 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 926569004766 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 926569004767 hypothetical protein; Validated; Region: PRK07411 926569004768 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 926569004769 ATP binding site [chemical binding]; other site 926569004770 substrate interface [chemical binding]; other site 926569004771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569004772 active site residue [active] 926569004773 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 926569004774 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 926569004775 Clp amino terminal domain; Region: Clp_N; pfam02861 926569004776 Clp amino terminal domain; Region: Clp_N; pfam02861 926569004777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569004778 Walker A motif; other site 926569004779 ATP binding site [chemical binding]; other site 926569004780 Walker B motif; other site 926569004781 arginine finger; other site 926569004782 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 926569004783 primary dimer interface [polypeptide binding]; other site 926569004784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569004785 Walker A motif; other site 926569004786 ATP binding site [chemical binding]; other site 926569004787 Walker B motif; other site 926569004788 arginine finger; other site 926569004789 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926569004790 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569004791 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569004792 phosphopeptide binding site; other site 926569004793 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926569004794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569004795 putative substrate translocation pore; other site 926569004796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569004797 Predicted methyltransferases [General function prediction only]; Region: COG0313 926569004798 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 926569004799 putative SAM binding site [chemical binding]; other site 926569004800 putative homodimer interface [polypeptide binding]; other site 926569004801 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 926569004802 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 926569004803 dimer interface [polypeptide binding]; other site 926569004804 active site 926569004805 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 926569004806 dimer interface [polypeptide binding]; other site 926569004807 active site 926569004808 thymidine kinase; Provisional; Region: PRK04296 926569004809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569004810 active site 926569004811 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 926569004812 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 926569004813 active site 926569004814 NTP binding site [chemical binding]; other site 926569004815 metal binding triad [ion binding]; metal-binding site 926569004816 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 926569004817 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 926569004818 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 926569004819 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926569004820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926569004821 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 926569004822 TAP-like protein; Region: Abhydrolase_4; pfam08386 926569004823 Response regulator receiver domain; Region: Response_reg; pfam00072 926569004824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004825 active site 926569004826 phosphorylation site [posttranslational modification] 926569004827 intermolecular recognition site; other site 926569004828 dimerization interface [polypeptide binding]; other site 926569004829 pyruvate phosphate dikinase; Provisional; Region: PRK09279 926569004830 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 926569004831 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 926569004832 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 926569004833 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 926569004834 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 926569004835 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926569004836 tetramer interface [polypeptide binding]; other site 926569004837 TPP-binding site [chemical binding]; other site 926569004838 heterodimer interface [polypeptide binding]; other site 926569004839 phosphorylation loop region [posttranslational modification] 926569004840 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926569004841 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926569004842 alpha subunit interface [polypeptide binding]; other site 926569004843 TPP binding site [chemical binding]; other site 926569004844 heterodimer interface [polypeptide binding]; other site 926569004845 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926569004846 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 926569004847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926569004848 E3 interaction surface; other site 926569004849 lipoyl attachment site [posttranslational modification]; other site 926569004850 e3 binding domain; Region: E3_binding; pfam02817 926569004851 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926569004852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569004853 binding surface 926569004854 TPR motif; other site 926569004855 TPR repeat; Region: TPR_11; pfam13414 926569004856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569004857 binding surface 926569004858 TPR motif; other site 926569004859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569004860 binding surface 926569004861 TPR motif; other site 926569004862 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 926569004863 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926569004864 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926569004865 catalytic residue [active] 926569004866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569004868 active site 926569004869 phosphorylation site [posttranslational modification] 926569004870 intermolecular recognition site; other site 926569004871 dimerization interface [polypeptide binding]; other site 926569004872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569004873 DNA binding residues [nucleotide binding] 926569004874 dimerization interface [polypeptide binding]; other site 926569004875 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 926569004876 AP (apurinic/apyrimidinic) site pocket; other site 926569004877 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 926569004878 DNA interaction; other site 926569004879 Metal-binding active site; metal-binding site 926569004880 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 926569004881 metal-binding heat shock protein; Provisional; Region: PRK00016 926569004882 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 926569004883 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 926569004884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569004885 Zn2+ binding site [ion binding]; other site 926569004886 Mg2+ binding site [ion binding]; other site 926569004887 Yqey-like protein; Region: YqeY; pfam09424 926569004888 SLBB domain; Region: SLBB; pfam10531 926569004889 comEA protein; Region: comE; TIGR01259 926569004890 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 926569004891 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 926569004892 hypothetical protein; Provisional; Region: PRK08201 926569004893 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 926569004894 metal binding site [ion binding]; metal-binding site 926569004895 putative dimer interface [polypeptide binding]; other site 926569004896 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 926569004897 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 926569004898 active site 926569004899 putative substrate binding pocket [chemical binding]; other site 926569004900 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 926569004901 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 926569004902 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 926569004903 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 926569004904 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 926569004905 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 926569004906 dimer interface [polypeptide binding]; other site 926569004907 substrate binding site [chemical binding]; other site 926569004908 phosphate binding site [ion binding]; other site 926569004909 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 926569004910 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 926569004911 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 926569004912 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 926569004913 putative oxidoreductase; Provisional; Region: PRK09799 926569004914 putative hypoxanthine oxidase; Provisional; Region: PRK09800 926569004915 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926569004916 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569004917 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569004918 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 926569004919 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 926569004920 XdhC Rossmann domain; Region: XdhC_C; pfam13478 926569004921 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 926569004922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 926569004923 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 926569004924 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926569004925 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 926569004926 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569004927 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569004928 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 926569004929 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 926569004930 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 926569004931 Ligand binding site; other site 926569004932 metal-binding site 926569004933 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 926569004934 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 926569004935 homodimer interface [polypeptide binding]; other site 926569004936 substrate-cofactor binding pocket; other site 926569004937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569004938 catalytic residue [active] 926569004939 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 926569004940 RNase_H superfamily; Region: RNase_H_2; pfam13482 926569004941 active site 926569004942 substrate binding site [chemical binding]; other site 926569004943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926569004944 TPR motif; other site 926569004945 binding surface 926569004946 TPR repeat; Region: TPR_11; pfam13414 926569004947 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926569004948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569004949 ATP binding site [chemical binding]; other site 926569004950 putative Mg++ binding site [ion binding]; other site 926569004951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569004952 nucleotide binding region [chemical binding]; other site 926569004953 ATP-binding site [chemical binding]; other site 926569004954 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 926569004955 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 926569004956 active site 926569004957 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 926569004958 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 926569004959 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 926569004960 active site 926569004961 substrate-binding site [chemical binding]; other site 926569004962 metal-binding site [ion binding] 926569004963 ATP binding site [chemical binding]; other site 926569004964 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569004965 transcription antitermination factor NusB; Region: nusB; TIGR01951 926569004966 putative RNA binding site [nucleotide binding]; other site 926569004967 Asp23 family; Region: Asp23; pfam03780 926569004968 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 926569004969 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 926569004970 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 926569004971 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 926569004972 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 926569004973 active site 926569004974 NAD binding site [chemical binding]; other site 926569004975 metal binding site [ion binding]; metal-binding site 926569004976 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 926569004977 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 926569004978 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 926569004979 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 926569004980 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 926569004981 putative NAD(P) binding site [chemical binding]; other site 926569004982 catalytic Zn binding site [ion binding]; other site 926569004983 structural Zn binding site [ion binding]; other site 926569004984 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926569004985 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926569004986 substrate binding pocket [chemical binding]; other site 926569004987 chain length determination region; other site 926569004988 substrate-Mg2+ binding site; other site 926569004989 catalytic residues [active] 926569004990 aspartate-rich region 1; other site 926569004991 active site lid residues [active] 926569004992 aspartate-rich region 2; other site 926569004993 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 926569004994 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 926569004995 active site 926569004996 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 926569004997 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 926569004998 active site 926569004999 substrate binding site [chemical binding]; other site 926569005000 metal binding site [ion binding]; metal-binding site 926569005001 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 926569005002 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 926569005003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569005004 catalytic residue [active] 926569005005 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 926569005006 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 926569005007 Ligand Binding Site [chemical binding]; other site 926569005008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926569005009 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569005010 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 926569005011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005012 S-adenosylmethionine binding site [chemical binding]; other site 926569005013 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 926569005014 putative active site [active] 926569005015 putative CoA binding site [chemical binding]; other site 926569005016 nudix motif; other site 926569005017 metal binding site [ion binding]; metal-binding site 926569005018 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 926569005019 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 926569005020 5S rRNA interface [nucleotide binding]; other site 926569005021 CTC domain interface [polypeptide binding]; other site 926569005022 L16 interface [polypeptide binding]; other site 926569005023 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 926569005024 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 926569005025 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 926569005026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569005027 catalytic loop [active] 926569005028 iron binding site [ion binding]; other site 926569005029 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926569005030 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926569005031 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926569005032 Uncharacterized conserved protein [Function unknown]; Region: COG1432 926569005033 LabA_like proteins; Region: LabA; cd10911 926569005034 putative metal binding site [ion binding]; other site 926569005035 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926569005036 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 926569005037 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 926569005038 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 926569005039 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 926569005040 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 926569005041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926569005042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005043 homodimer interface [polypeptide binding]; other site 926569005044 catalytic residue [active] 926569005045 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 926569005046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 926569005047 dimer interface [polypeptide binding]; other site 926569005048 active site 926569005049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 926569005050 folate binding site [chemical binding]; other site 926569005051 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 926569005052 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 926569005053 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569005054 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569005055 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569005056 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569005057 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569005058 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926569005059 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 926569005060 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 926569005061 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 926569005062 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926569005063 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 926569005064 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 926569005065 lycopene cyclase; Region: lycopene_cycl; TIGR01789 926569005066 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 926569005067 putative substrate binding pocket [chemical binding]; other site 926569005068 AC domain interface; other site 926569005069 catalytic triad [active] 926569005070 AB domain interface; other site 926569005071 interchain disulfide; other site 926569005072 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 926569005073 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 926569005074 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 926569005075 putative active site [active] 926569005076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569005077 Uncharacterized conserved protein [Function unknown]; Region: COG3268 926569005078 NAD(P) binding site [chemical binding]; other site 926569005079 Fructosamine kinase; Region: Fructosamin_kin; cl17579 926569005080 Phosphotransferase enzyme family; Region: APH; pfam01636 926569005081 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 926569005082 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926569005083 active site 926569005084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569005085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569005086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569005087 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 926569005088 active site 926569005089 catalytic residues [active] 926569005090 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 926569005091 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 926569005092 XdhC Rossmann domain; Region: XdhC_C; pfam13478 926569005093 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 926569005094 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 926569005095 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926569005096 trimer interface [polypeptide binding]; other site 926569005097 substrate binding site [chemical binding]; other site 926569005098 Mn binding site [ion binding]; other site 926569005099 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 926569005100 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926569005101 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569005102 catalytic residues [active] 926569005103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569005104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005105 active site 926569005106 phosphorylation site [posttranslational modification] 926569005107 intermolecular recognition site; other site 926569005108 dimerization interface [polypeptide binding]; other site 926569005109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569005110 DNA binding site [nucleotide binding] 926569005111 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569005112 Double zinc ribbon; Region: DZR; pfam12773 926569005113 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569005114 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569005115 phosphopeptide binding site; other site 926569005116 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926569005117 HSP70 interaction site [polypeptide binding]; other site 926569005118 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 926569005119 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926569005120 metal ion-dependent adhesion site (MIDAS); other site 926569005121 Protein phosphatase 2C; Region: PP2C; pfam00481 926569005122 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 926569005123 active site 926569005124 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 926569005125 Catalytic domain of Protein Kinases; Region: PKc; cd00180 926569005126 active site 926569005127 ATP binding site [chemical binding]; other site 926569005128 substrate binding site [chemical binding]; other site 926569005129 activation loop (A-loop); other site 926569005130 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926569005131 Trp docking motif [polypeptide binding]; other site 926569005132 PQQ-like domain; Region: PQQ_2; pfam13360 926569005133 active site 926569005134 PQQ-like domain; Region: PQQ_2; pfam13360 926569005135 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 926569005136 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 926569005137 tetramer interface [polypeptide binding]; other site 926569005138 Protein of unknown function (DUF971); Region: DUF971; pfam06155 926569005139 calcium/proton exchanger (cax); Region: cax; TIGR00378 926569005140 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926569005141 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926569005142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 926569005143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 926569005144 active site 926569005145 ATP binding site [chemical binding]; other site 926569005146 substrate binding site [chemical binding]; other site 926569005147 activation loop (A-loop); other site 926569005148 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 926569005149 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 926569005150 substrate binding site [chemical binding]; other site 926569005151 hexamer interface [polypeptide binding]; other site 926569005152 metal binding site [ion binding]; metal-binding site 926569005153 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 926569005154 Asp23 family; Region: Asp23; pfam03780 926569005155 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 926569005156 DAK2 domain; Region: Dak2; pfam02734 926569005157 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569005158 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569005159 Y-family of DNA polymerases; Region: PolY; cl12025 926569005160 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 926569005161 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 926569005162 generic binding surface II; other site 926569005163 ssDNA binding site; other site 926569005164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569005165 ATP binding site [chemical binding]; other site 926569005166 putative Mg++ binding site [ion binding]; other site 926569005167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569005168 nucleotide binding region [chemical binding]; other site 926569005169 ATP-binding site [chemical binding]; other site 926569005170 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 926569005171 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 926569005172 active site 926569005173 (T/H)XGH motif; other site 926569005174 potential frameshift: common BLAST hit: gi|159899515|ref|YP_001545762.1| ATP-dependent protease La 926569005175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569005176 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569005177 Walker A motif; other site 926569005178 ATP binding site [chemical binding]; other site 926569005179 Walker B motif; other site 926569005180 arginine finger; other site 926569005181 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 926569005182 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 926569005183 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 926569005184 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926569005185 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926569005186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569005187 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569005188 ligand binding site [chemical binding]; other site 926569005189 flexible hinge region; other site 926569005190 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926569005191 putative switch regulator; other site 926569005192 non-specific DNA interactions [nucleotide binding]; other site 926569005193 DNA binding site [nucleotide binding] 926569005194 sequence specific DNA binding site [nucleotide binding]; other site 926569005195 putative cAMP binding site [chemical binding]; other site 926569005196 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 926569005197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569005198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005199 active site 926569005200 phosphorylation site [posttranslational modification] 926569005201 intermolecular recognition site; other site 926569005202 dimerization interface [polypeptide binding]; other site 926569005203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569005204 DNA binding site [nucleotide binding] 926569005205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569005206 dimerization interface [polypeptide binding]; other site 926569005207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569005208 dimer interface [polypeptide binding]; other site 926569005209 phosphorylation site [posttranslational modification] 926569005210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005211 ATP binding site [chemical binding]; other site 926569005212 Mg2+ binding site [ion binding]; other site 926569005213 G-X-G motif; other site 926569005214 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 926569005215 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 926569005216 Ligand binding site; other site 926569005217 YceI-like domain; Region: YceI; pfam04264 926569005218 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569005219 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569005220 active site 926569005221 catalytic tetrad [active] 926569005222 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 926569005223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926569005224 active site 926569005225 catalytic site [active] 926569005226 substrate binding site [chemical binding]; other site 926569005227 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 926569005228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 926569005229 diaminopimelate decarboxylase; Region: lysA; TIGR01048 926569005230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 926569005231 active site 926569005232 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926569005233 substrate binding site [chemical binding]; other site 926569005234 catalytic residues [active] 926569005235 dimer interface [polypeptide binding]; other site 926569005236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569005237 non-specific DNA binding site [nucleotide binding]; other site 926569005238 salt bridge; other site 926569005239 sequence-specific DNA binding site [nucleotide binding]; other site 926569005240 Cupin domain; Region: Cupin_2; pfam07883 926569005241 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 926569005242 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 926569005243 purine monophosphate binding site [chemical binding]; other site 926569005244 dimer interface [polypeptide binding]; other site 926569005245 putative catalytic residues [active] 926569005246 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 926569005247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 926569005248 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 926569005249 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 926569005250 Cl binding site [ion binding]; other site 926569005251 oligomer interface [polypeptide binding]; other site 926569005252 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 926569005253 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 926569005254 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 926569005255 putative RNA binding site [nucleotide binding]; other site 926569005256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005257 S-adenosylmethionine binding site [chemical binding]; other site 926569005258 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 926569005259 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 926569005260 nucleotide binding pocket [chemical binding]; other site 926569005261 K-X-D-G motif; other site 926569005262 catalytic site [active] 926569005263 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 926569005264 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 926569005265 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 926569005266 Dimer interface [polypeptide binding]; other site 926569005267 BRCT sequence motif; other site 926569005268 hypothetical protein; Provisional; Region: PRK05839 926569005269 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 926569005270 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 926569005271 putative GEF interaction site [polypeptide binding]; other site 926569005272 G1 box; other site 926569005273 GTP/Mg2+ binding site [chemical binding]; other site 926569005274 Switch I region; other site 926569005275 G2 box; other site 926569005276 G3 box; other site 926569005277 Switch II region; other site 926569005278 G4 box; other site 926569005279 G5 box; other site 926569005280 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 926569005281 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 926569005282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569005283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005284 active site 926569005285 phosphorylation site [posttranslational modification] 926569005286 intermolecular recognition site; other site 926569005287 dimerization interface [polypeptide binding]; other site 926569005288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569005289 DNA binding residues [nucleotide binding] 926569005290 dimerization interface [polypeptide binding]; other site 926569005291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569005292 Histidine kinase; Region: HisKA_3; pfam07730 926569005293 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 926569005294 ATP binding site [chemical binding]; other site 926569005295 Mg2+ binding site [ion binding]; other site 926569005296 G-X-G motif; other site 926569005297 short chain dehydrogenase; Provisional; Region: PRK07832 926569005298 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 926569005299 putative NAD(P) binding site [chemical binding]; other site 926569005300 homotetramer interface [polypeptide binding]; other site 926569005301 active site 926569005302 homodimer interface [polypeptide binding]; other site 926569005303 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 926569005304 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 926569005305 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 926569005306 B12 binding site [chemical binding]; other site 926569005307 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 926569005308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005309 FeS/SAM binding site; other site 926569005310 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 926569005311 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 926569005312 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 926569005313 homodimer interface [polypeptide binding]; other site 926569005314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005315 catalytic residue [active] 926569005316 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 926569005317 dimer interface [polypeptide binding]; other site 926569005318 substrate binding site [chemical binding]; other site 926569005319 metal binding sites [ion binding]; metal-binding site 926569005320 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 926569005321 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 926569005322 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 926569005323 dimer interface [polypeptide binding]; other site 926569005324 PYR/PP interface [polypeptide binding]; other site 926569005325 TPP binding site [chemical binding]; other site 926569005326 substrate binding site [chemical binding]; other site 926569005327 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 926569005328 TPP-binding site; other site 926569005329 4Fe-4S binding domain; Region: Fer4; pfam00037 926569005330 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 926569005331 CoA binding domain; Region: CoA_binding_2; pfam13380 926569005332 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 926569005333 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 926569005334 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 926569005335 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 926569005336 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569005337 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569005338 Walker A/P-loop; other site 926569005339 ATP binding site [chemical binding]; other site 926569005340 Q-loop/lid; other site 926569005341 ABC transporter signature motif; other site 926569005342 Walker B; other site 926569005343 D-loop; other site 926569005344 H-loop/switch region; other site 926569005345 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926569005346 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 926569005347 Walker A/P-loop; other site 926569005348 ATP binding site [chemical binding]; other site 926569005349 Q-loop/lid; other site 926569005350 ABC transporter signature motif; other site 926569005351 Walker B; other site 926569005352 D-loop; other site 926569005353 H-loop/switch region; other site 926569005354 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 926569005355 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 926569005356 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569005357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569005358 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569005359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569005360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569005361 dimer interface [polypeptide binding]; other site 926569005362 phosphorylation site [posttranslational modification] 926569005363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005364 ATP binding site [chemical binding]; other site 926569005365 Mg2+ binding site [ion binding]; other site 926569005366 G-X-G motif; other site 926569005367 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569005368 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 926569005369 active site 926569005370 DNA binding site [nucleotide binding] 926569005371 Int/Topo IB signature motif; other site 926569005372 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 926569005373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005374 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 926569005375 FeS/SAM binding site; other site 926569005376 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 926569005377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005378 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 926569005379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005380 S-adenosylmethionine binding site [chemical binding]; other site 926569005381 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 926569005382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005383 FeS/SAM binding site; other site 926569005384 HemN C-terminal domain; Region: HemN_C; pfam06969 926569005385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 926569005386 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926569005387 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 926569005388 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 926569005389 dimer interface [polypeptide binding]; other site 926569005390 active site 926569005391 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569005392 GAF domain; Region: GAF; pfam01590 926569005393 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 926569005394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005395 FeS/SAM binding site; other site 926569005396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569005397 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 926569005398 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569005399 putative trimer interface [polypeptide binding]; other site 926569005400 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 926569005401 trimer interface [polypeptide binding]; other site 926569005402 active site 926569005403 substrate binding site [chemical binding]; other site 926569005404 putative CoA binding site [chemical binding]; other site 926569005405 CoA binding site [chemical binding]; other site 926569005406 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569005407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569005408 NAD(P) binding site [chemical binding]; other site 926569005409 active site 926569005410 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 926569005411 RNA/DNA hybrid binding site [nucleotide binding]; other site 926569005412 active site 926569005413 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926569005414 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 926569005415 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926569005416 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 926569005417 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 926569005418 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569005419 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926569005420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005421 S-adenosylmethionine binding site [chemical binding]; other site 926569005422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569005423 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569005424 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569005425 GTP-binding protein LepA; Provisional; Region: PRK05433 926569005426 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 926569005427 G1 box; other site 926569005428 putative GEF interaction site [polypeptide binding]; other site 926569005429 GTP/Mg2+ binding site [chemical binding]; other site 926569005430 Switch I region; other site 926569005431 G2 box; other site 926569005432 G3 box; other site 926569005433 Switch II region; other site 926569005434 G4 box; other site 926569005435 G5 box; other site 926569005436 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 926569005437 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 926569005438 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 926569005439 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 926569005440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926569005441 RNA binding surface [nucleotide binding]; other site 926569005442 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 926569005443 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 926569005444 mevalonate kinase; Region: mevalon_kin; TIGR00549 926569005445 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926569005446 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 926569005447 putative nucleotide binding site [chemical binding]; other site 926569005448 putative substrate binding site [chemical binding]; other site 926569005449 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 926569005450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569005451 Zn2+ binding site [ion binding]; other site 926569005452 Mg2+ binding site [ion binding]; other site 926569005453 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 926569005454 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 926569005455 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 926569005456 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926569005457 DNA topoisomerase I; Validated; Region: PRK05582 926569005458 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 926569005459 active site 926569005460 interdomain interaction site; other site 926569005461 putative metal-binding site [ion binding]; other site 926569005462 nucleotide binding site [chemical binding]; other site 926569005463 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926569005464 domain I; other site 926569005465 DNA binding groove [nucleotide binding] 926569005466 phosphate binding site [ion binding]; other site 926569005467 domain II; other site 926569005468 domain III; other site 926569005469 nucleotide binding site [chemical binding]; other site 926569005470 catalytic site [active] 926569005471 domain IV; other site 926569005472 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 926569005473 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 926569005474 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 926569005475 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 926569005476 Substrate binding site; other site 926569005477 Cupin domain; Region: Cupin_2; cl17218 926569005478 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 926569005479 DNA protecting protein DprA; Region: dprA; TIGR00732 926569005480 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 926569005481 RimM N-terminal domain; Region: RimM; pfam01782 926569005482 PRC-barrel domain; Region: PRC; pfam05239 926569005483 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 926569005484 KH domain; Region: KH_4; pfam13083 926569005485 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 926569005486 signal recognition particle protein; Provisional; Region: PRK10867 926569005487 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 926569005488 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 926569005489 P loop; other site 926569005490 GTP binding site [chemical binding]; other site 926569005491 Signal peptide binding domain; Region: SRP_SPB; pfam02978 926569005492 Predicted transcriptional regulator [Transcription]; Region: COG3355 926569005493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569005494 dimerization interface [polypeptide binding]; other site 926569005495 putative DNA binding site [nucleotide binding]; other site 926569005496 putative Zn2+ binding site [ion binding]; other site 926569005497 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 926569005498 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 926569005499 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 926569005500 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 926569005501 active site 926569005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569005503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569005504 putative substrate translocation pore; other site 926569005505 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926569005506 phosphodiesterase; Provisional; Region: PRK12704 926569005507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569005508 Zn2+ binding site [ion binding]; other site 926569005509 Mg2+ binding site [ion binding]; other site 926569005510 RecX family; Region: RecX; cl00936 926569005511 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 926569005512 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569005513 ATP binding site [chemical binding]; other site 926569005514 ATP binding site [chemical binding]; other site 926569005515 substrate binding site [chemical binding]; other site 926569005516 substrate binding site [chemical binding]; other site 926569005517 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 926569005518 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 926569005519 putative metal binding site [ion binding]; other site 926569005520 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 926569005521 putative deacylase active site [active] 926569005522 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 926569005523 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 926569005524 homotetramer interface [polypeptide binding]; other site 926569005525 ligand binding site [chemical binding]; other site 926569005526 catalytic site [active] 926569005527 NAD binding site [chemical binding]; other site 926569005528 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569005529 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 926569005530 substrate binding site [chemical binding]; other site 926569005531 ATP binding site [chemical binding]; other site 926569005532 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 926569005533 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 926569005534 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 926569005535 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 926569005536 NAD binding site [chemical binding]; other site 926569005537 dimer interface [polypeptide binding]; other site 926569005538 substrate binding site [chemical binding]; other site 926569005539 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569005540 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 926569005541 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 926569005542 Ca binding site [ion binding]; other site 926569005543 active site 926569005544 catalytic site [active] 926569005545 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 926569005546 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926569005547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005548 FeS/SAM binding site; other site 926569005549 TPR repeat; Region: TPR_11; pfam13414 926569005550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005551 binding surface 926569005552 TPR motif; other site 926569005553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005554 binding surface 926569005555 TPR motif; other site 926569005556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005557 TPR motif; other site 926569005558 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 926569005559 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 926569005560 active site 926569005561 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 926569005562 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 926569005563 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 926569005564 active site 926569005565 FMN binding site [chemical binding]; other site 926569005566 substrate binding site [chemical binding]; other site 926569005567 3Fe-4S cluster binding site [ion binding]; other site 926569005568 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 926569005569 domain_subunit interface; other site 926569005570 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569005571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005572 active site 926569005573 phosphorylation site [posttranslational modification] 926569005574 intermolecular recognition site; other site 926569005575 dimerization interface [polypeptide binding]; other site 926569005576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569005577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005578 active site 926569005579 phosphorylation site [posttranslational modification] 926569005580 intermolecular recognition site; other site 926569005581 dimerization interface [polypeptide binding]; other site 926569005582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569005583 dimerization interface [polypeptide binding]; other site 926569005584 DNA binding residues [nucleotide binding] 926569005585 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569005586 GAF domain; Region: GAF; pfam01590 926569005587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569005588 GAF domain; Region: GAF_3; pfam13492 926569005589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569005590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005591 ATP binding site [chemical binding]; other site 926569005592 G-X-G motif; other site 926569005593 Formate--tetrahydrofolate ligase; Region: PLN02759 926569005594 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 926569005595 Potassium binding sites [ion binding]; other site 926569005596 Cesium cation binding sites [ion binding]; other site 926569005597 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 926569005598 pyrroline-5-carboxylate reductase; Region: PLN02688 926569005599 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 926569005600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005601 S-adenosylmethionine binding site [chemical binding]; other site 926569005602 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 926569005603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926569005604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005605 homodimer interface [polypeptide binding]; other site 926569005606 catalytic residue [active] 926569005607 Uncharacterized conserved protein [Function unknown]; Region: COG1434 926569005608 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926569005609 putative active site [active] 926569005610 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926569005611 DNA-binding site [nucleotide binding]; DNA binding site 926569005612 RNA-binding motif; other site 926569005613 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 926569005614 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 926569005615 glutaminase active site [active] 926569005616 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926569005617 dimer interface [polypeptide binding]; other site 926569005618 active site 926569005619 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926569005620 dimer interface [polypeptide binding]; other site 926569005621 active site 926569005622 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 926569005623 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 926569005624 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 926569005625 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569005626 catalytic core [active] 926569005627 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 926569005628 putative deacylase active site [active] 926569005629 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569005630 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569005631 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569005632 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569005633 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 926569005634 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569005635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005636 active site 926569005637 phosphorylation site [posttranslational modification] 926569005638 intermolecular recognition site; other site 926569005639 dimerization interface [polypeptide binding]; other site 926569005640 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 926569005641 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 926569005642 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 926569005643 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569005644 Ycf46; Provisional; Region: ycf46; CHL00195 926569005645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569005646 Walker A motif; other site 926569005647 ATP binding site [chemical binding]; other site 926569005648 Walker B motif; other site 926569005649 arginine finger; other site 926569005650 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569005651 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569005652 structural tetrad; other site 926569005653 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 926569005654 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 926569005655 nucleotide binding site [chemical binding]; other site 926569005656 putative NEF/HSP70 interaction site [polypeptide binding]; other site 926569005657 SBD interface [polypeptide binding]; other site 926569005658 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 926569005659 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 926569005660 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 926569005661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005662 FeS/SAM binding site; other site 926569005663 HEAT repeats; Region: HEAT_2; pfam13646 926569005664 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569005665 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 926569005666 structural tetrad; other site 926569005667 sugar efflux transporter; Region: 2A0120; TIGR00899 926569005668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569005669 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569005670 active site residue [active] 926569005671 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569005672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569005673 NAD(P) binding site [chemical binding]; other site 926569005674 active site 926569005675 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 926569005676 CoA binding domain; Region: CoA_binding_2; pfam13380 926569005677 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 926569005678 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 926569005679 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 926569005680 trigger factor; Region: tig; TIGR00115 926569005681 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 926569005682 Clp protease; Region: CLP_protease; pfam00574 926569005683 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 926569005684 oligomer interface [polypeptide binding]; other site 926569005685 active site residues [active] 926569005686 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 926569005687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569005688 active site 926569005689 motif I; other site 926569005690 motif II; other site 926569005691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569005692 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 926569005693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005694 FeS/SAM binding site; other site 926569005695 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 926569005696 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 926569005697 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 926569005698 P loop; other site 926569005699 GTP binding site [chemical binding]; other site 926569005700 peptide chain release factor 2; Validated; Region: prfB; PRK00578 926569005701 This domain is found in peptide chain release factors; Region: PCRF; smart00937 926569005702 RF-1 domain; Region: RF-1; pfam00472 926569005703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569005704 catalytic loop [active] 926569005705 iron binding site [ion binding]; other site 926569005706 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 926569005707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569005708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926569005709 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 926569005710 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 926569005711 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926569005712 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926569005713 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 926569005714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569005715 Zn2+ binding site [ion binding]; other site 926569005716 Mg2+ binding site [ion binding]; other site 926569005717 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 926569005718 synthetase active site [active] 926569005719 NTP binding site [chemical binding]; other site 926569005720 metal binding site [ion binding]; metal-binding site 926569005721 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 926569005722 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 926569005723 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 926569005724 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 926569005725 dimer interface [polypeptide binding]; other site 926569005726 putative functional site; other site 926569005727 putative MPT binding site; other site 926569005728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569005730 putative substrate translocation pore; other site 926569005731 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926569005732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569005733 S-adenosylmethionine binding site [chemical binding]; other site 926569005734 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 926569005735 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926569005736 TrkA-N domain; Region: TrkA_N; pfam02254 926569005737 TrkA-C domain; Region: TrkA_C; pfam02080 926569005738 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569005739 protein-export membrane protein SecD; Region: secD; TIGR01129 926569005740 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 926569005741 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 926569005742 Protein export membrane protein; Region: SecD_SecF; cl14618 926569005743 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 926569005744 lipoyl attachment site [posttranslational modification]; other site 926569005745 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 926569005746 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926569005747 tetramer interface [polypeptide binding]; other site 926569005748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005749 catalytic residue [active] 926569005750 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 926569005751 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926569005752 tetramer interface [polypeptide binding]; other site 926569005753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005754 catalytic residue [active] 926569005755 phosphodiesterase YaeI; Provisional; Region: PRK11340 926569005756 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 926569005757 putative active site [active] 926569005758 putative metal binding site [ion binding]; other site 926569005759 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 926569005760 multifunctional aminopeptidase A; Provisional; Region: PRK00913 926569005761 interface (dimer of trimers) [polypeptide binding]; other site 926569005762 Substrate-binding/catalytic site; other site 926569005763 Zn-binding sites [ion binding]; other site 926569005764 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 926569005765 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 926569005766 motif 1; other site 926569005767 active site 926569005768 motif 2; other site 926569005769 motif 3; other site 926569005770 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 926569005771 DHHA1 domain; Region: DHHA1; pfam02272 926569005772 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 926569005773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005774 binding surface 926569005775 TPR motif; other site 926569005776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005777 TPR motif; other site 926569005778 binding surface 926569005779 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 926569005780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005781 binding surface 926569005782 TPR motif; other site 926569005783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005784 binding surface 926569005785 TPR motif; other site 926569005786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005787 binding surface 926569005788 TPR motif; other site 926569005789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005790 TPR motif; other site 926569005791 binding surface 926569005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005793 binding surface 926569005794 TPR motif; other site 926569005795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005796 TPR motif; other site 926569005797 TPR repeat; Region: TPR_11; pfam13414 926569005798 binding surface 926569005799 TPR repeat; Region: TPR_11; pfam13414 926569005800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569005801 TPR motif; other site 926569005802 binding surface 926569005803 TPR repeat; Region: TPR_11; pfam13414 926569005804 Response regulator receiver domain; Region: Response_reg; pfam00072 926569005805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005806 active site 926569005807 phosphorylation site [posttranslational modification] 926569005808 intermolecular recognition site; other site 926569005809 dimerization interface [polypeptide binding]; other site 926569005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569005811 Walker A motif; other site 926569005812 ATP binding site [chemical binding]; other site 926569005813 Walker B motif; other site 926569005814 arginine finger; other site 926569005815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569005816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569005817 putative active site [active] 926569005818 heme pocket [chemical binding]; other site 926569005819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569005820 dimer interface [polypeptide binding]; other site 926569005821 phosphorylation site [posttranslational modification] 926569005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005823 ATP binding site [chemical binding]; other site 926569005824 Mg2+ binding site [ion binding]; other site 926569005825 G-X-G motif; other site 926569005826 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 926569005827 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 926569005828 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 926569005829 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 926569005830 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 926569005831 Glucose inhibited division protein A; Region: GIDA; pfam01134 926569005832 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926569005833 Peptidase family M28; Region: Peptidase_M28; pfam04389 926569005834 metal binding site [ion binding]; metal-binding site 926569005835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569005836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569005837 dimer interface [polypeptide binding]; other site 926569005838 phosphorylation site [posttranslational modification] 926569005839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005840 ATP binding site [chemical binding]; other site 926569005841 Mg2+ binding site [ion binding]; other site 926569005842 G-X-G motif; other site 926569005843 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 926569005844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926569005845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005846 homodimer interface [polypeptide binding]; other site 926569005847 catalytic residue [active] 926569005848 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 926569005849 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 926569005850 HflX GTPase family; Region: HflX; cd01878 926569005851 G1 box; other site 926569005852 GTP/Mg2+ binding site [chemical binding]; other site 926569005853 Switch I region; other site 926569005854 G2 box; other site 926569005855 G3 box; other site 926569005856 Switch II region; other site 926569005857 G4 box; other site 926569005858 G5 box; other site 926569005859 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 926569005860 glyoxylate reductase; Reviewed; Region: PRK13243 926569005861 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 926569005862 dimerization interface [polypeptide binding]; other site 926569005863 ligand binding site [chemical binding]; other site 926569005864 NADP binding site [chemical binding]; other site 926569005865 catalytic site [active] 926569005866 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 926569005867 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 926569005868 active site 926569005869 homodimer interface [polypeptide binding]; other site 926569005870 catalytic site [active] 926569005871 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 926569005872 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 926569005873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926569005874 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 926569005875 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 926569005876 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 926569005877 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 926569005878 EamA-like transporter family; Region: EamA; pfam00892 926569005879 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 926569005880 EamA-like transporter family; Region: EamA; pfam00892 926569005881 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 926569005882 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 926569005883 active site 926569005884 catalytic site [active] 926569005885 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926569005886 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926569005887 inhibitor-cofactor binding pocket; inhibition site 926569005888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005889 catalytic residue [active] 926569005890 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 926569005891 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 926569005892 Substrate binding site; other site 926569005893 metal-binding site 926569005894 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 926569005895 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 926569005896 NAD binding site [chemical binding]; other site 926569005897 substrate binding site [chemical binding]; other site 926569005898 active site 926569005899 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569005900 CoA-binding domain; Region: CoA_binding_3; pfam13727 926569005901 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569005902 Chain length determinant protein; Region: Wzz; cl15801 926569005903 Chain length determinant protein; Region: Wzz; cl15801 926569005904 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 926569005905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569005906 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569005907 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569005908 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569005909 TM-ABC transporter signature motif; other site 926569005910 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 926569005911 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569005912 Walker A/P-loop; other site 926569005913 ATP binding site [chemical binding]; other site 926569005914 Q-loop/lid; other site 926569005915 ABC transporter signature motif; other site 926569005916 Walker B; other site 926569005917 D-loop; other site 926569005918 H-loop/switch region; other site 926569005919 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569005920 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 926569005921 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 926569005922 putative ligand binding site [chemical binding]; other site 926569005923 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 926569005924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569005925 Walker A/P-loop; other site 926569005926 ATP binding site [chemical binding]; other site 926569005927 Q-loop/lid; other site 926569005928 ABC transporter signature motif; other site 926569005929 Walker B; other site 926569005930 D-loop; other site 926569005931 H-loop/switch region; other site 926569005932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569005933 Histidine kinase; Region: HisKA_3; pfam07730 926569005934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569005935 ATP binding site [chemical binding]; other site 926569005936 Mg2+ binding site [ion binding]; other site 926569005937 G-X-G motif; other site 926569005938 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 926569005939 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 926569005940 ligand binding site [chemical binding]; other site 926569005941 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569005942 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926569005943 TM-ABC transporter signature motif; other site 926569005944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569005945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569005946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005947 active site 926569005948 phosphorylation site [posttranslational modification] 926569005949 intermolecular recognition site; other site 926569005950 dimerization interface [polypeptide binding]; other site 926569005951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569005952 DNA binding residues [nucleotide binding] 926569005953 dimerization interface [polypeptide binding]; other site 926569005954 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569005955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569005956 active site 926569005957 phosphorylation site [posttranslational modification] 926569005958 intermolecular recognition site; other site 926569005959 dimerization interface [polypeptide binding]; other site 926569005960 ThiS family; Region: ThiS; pfam02597 926569005961 charged pocket; other site 926569005962 hydrophobic patch; other site 926569005963 Ubiquitin-like proteins; Region: UBQ; cl00155 926569005964 charged pocket; other site 926569005965 hydrophobic patch; other site 926569005966 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 926569005967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569005968 FeS/SAM binding site; other site 926569005969 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 926569005970 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 926569005971 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 926569005972 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 926569005973 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569005974 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569005975 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926569005976 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569005977 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 926569005978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926569005979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926569005980 hypothetical protein; Provisional; Region: PRK06062 926569005981 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926569005982 inhibitor-cofactor binding pocket; inhibition site 926569005983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569005984 catalytic residue [active] 926569005985 Domain of unknown function (DUF309); Region: DUF309; pfam03745 926569005986 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 926569005987 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 926569005988 putative NAD(P) binding site [chemical binding]; other site 926569005989 active site 926569005990 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 926569005991 putative active site [active] 926569005992 putative metal binding site [ion binding]; other site 926569005993 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 926569005994 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 926569005995 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 926569005996 putative active site [active] 926569005997 putative metal binding site [ion binding]; other site 926569005998 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 926569005999 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 926569006000 active site 926569006001 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 926569006002 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 926569006003 active site 926569006004 catalytic site [active] 926569006005 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 926569006006 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 926569006007 active site 926569006008 catalytic site [active] 926569006009 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 926569006010 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 926569006011 NmrA-like family; Region: NmrA; pfam05368 926569006012 putative NAD(P) binding site [chemical binding]; other site 926569006013 active site 926569006014 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 926569006015 nucleotide binding site [chemical binding]; other site 926569006016 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 926569006017 SulA interaction site; other site 926569006018 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569006019 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569006020 DNA binding site [nucleotide binding] 926569006021 domain linker motif; other site 926569006022 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926569006023 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 926569006024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569006025 motif II; other site 926569006026 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569006027 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569006028 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 926569006029 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569006030 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926569006031 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569006032 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 926569006033 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926569006034 homodimer interface [polypeptide binding]; other site 926569006035 substrate-cofactor binding pocket; other site 926569006036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569006037 catalytic residue [active] 926569006038 Homoserine O-succinyltransferase; Region: HTS; pfam04204 926569006039 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 926569006040 proposed active site lysine [active] 926569006041 conserved cys residue [active] 926569006042 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 926569006043 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 926569006044 FMN binding site [chemical binding]; other site 926569006045 substrate binding site [chemical binding]; other site 926569006046 putative catalytic residue [active] 926569006047 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 926569006048 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 926569006049 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 926569006050 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 926569006051 active site 926569006052 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 926569006053 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 926569006054 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 926569006055 active site 926569006056 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 926569006057 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 926569006058 putative NADP binding site [chemical binding]; other site 926569006059 active site 926569006060 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 926569006061 META domain; Region: META; pfam03724 926569006062 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926569006063 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 926569006064 active site 926569006065 catalytic site [active] 926569006066 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 926569006067 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 926569006068 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926569006069 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926569006070 PA14 domain; Region: PA14; cl08459 926569006071 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926569006072 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 926569006073 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 926569006074 active site 926569006075 Zn binding site [ion binding]; other site 926569006076 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 926569006077 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 926569006078 short chain dehydrogenase; Provisional; Region: PRK06179 926569006079 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 926569006080 NADP binding site [chemical binding]; other site 926569006081 active site 926569006082 steroid binding site; other site 926569006083 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 926569006084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926569006085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926569006086 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 926569006087 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 926569006088 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 926569006089 putative NADP binding site [chemical binding]; other site 926569006090 putative substrate binding site [chemical binding]; other site 926569006091 active site 926569006092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569006093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569006094 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 926569006095 active site 926569006096 NAD binding site [chemical binding]; other site 926569006097 metal binding site [ion binding]; metal-binding site 926569006098 Predicted dehydrogenase [General function prediction only]; Region: COG0579 926569006099 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926569006100 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 926569006101 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926569006102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006103 Walker A motif; other site 926569006104 ATP binding site [chemical binding]; other site 926569006105 Walker B motif; other site 926569006106 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 926569006107 PAC2 family; Region: PAC2; cl00847 926569006108 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926569006109 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 926569006110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926569006111 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926569006112 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926569006113 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569006114 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926569006115 substrate binding site [chemical binding]; other site 926569006116 ATP binding site [chemical binding]; other site 926569006117 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926569006118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926569006119 active site 926569006120 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 926569006121 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 926569006122 dimer interface [polypeptide binding]; other site 926569006123 motif 1; other site 926569006124 active site 926569006125 motif 2; other site 926569006126 motif 3; other site 926569006127 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 926569006128 anticodon binding site; other site 926569006129 DRTGG domain; Region: DRTGG; pfam07085 926569006130 FOG: CBS domain [General function prediction only]; Region: COG0517 926569006131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926569006132 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 926569006133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569006134 ATP binding site [chemical binding]; other site 926569006135 Mg2+ binding site [ion binding]; other site 926569006136 G-X-G motif; other site 926569006137 DRTGG domain; Region: DRTGG; pfam07085 926569006138 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 926569006139 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 926569006140 active site 926569006141 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926569006142 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 926569006143 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 926569006144 putative dimer interface [polypeptide binding]; other site 926569006145 [2Fe-2S] cluster binding site [ion binding]; other site 926569006146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569006147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569006148 ATP binding site [chemical binding]; other site 926569006149 Mg2+ binding site [ion binding]; other site 926569006150 G-X-G motif; other site 926569006151 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 926569006152 dimer interface [polypeptide binding]; other site 926569006153 [2Fe-2S] cluster binding site [ion binding]; other site 926569006154 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 926569006155 dimer interface [polypeptide binding]; other site 926569006156 [2Fe-2S] cluster binding site [ion binding]; other site 926569006157 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 926569006158 SLBB domain; Region: SLBB; pfam10531 926569006159 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 926569006160 4Fe-4S binding domain; Region: Fer4; pfam00037 926569006161 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 926569006162 4Fe-4S binding domain; Region: Fer4; pfam00037 926569006163 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 926569006164 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 926569006165 putative dimer interface [polypeptide binding]; other site 926569006166 [2Fe-2S] cluster binding site [ion binding]; other site 926569006167 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 926569006168 dimer interface [polypeptide binding]; other site 926569006169 [2Fe-2S] cluster binding site [ion binding]; other site 926569006170 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 926569006171 SLBB domain; Region: SLBB; pfam10531 926569006172 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 926569006173 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569006174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569006175 ligand binding site [chemical binding]; other site 926569006176 flexible hinge region; other site 926569006177 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 926569006178 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 926569006179 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 926569006180 G1 box; other site 926569006181 GTP/Mg2+ binding site [chemical binding]; other site 926569006182 G2 box; other site 926569006183 Switch I region; other site 926569006184 G3 box; other site 926569006185 Switch II region; other site 926569006186 G4 box; other site 926569006187 G5 box; other site 926569006188 Acylphosphatase; Region: Acylphosphatase; pfam00708 926569006189 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 926569006190 HypF finger; Region: zf-HYPF; pfam07503 926569006191 HypF finger; Region: zf-HYPF; pfam07503 926569006192 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 926569006193 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 926569006194 HupF/HypC family; Region: HupF_HypC; pfam01455 926569006195 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 926569006196 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 926569006197 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 926569006198 dimerization interface [polypeptide binding]; other site 926569006199 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 926569006200 ATP binding site [chemical binding]; other site 926569006201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569006202 S-adenosylmethionine binding site [chemical binding]; other site 926569006203 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 926569006204 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 926569006205 [2Fe-2S] cluster binding site [ion binding]; other site 926569006206 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 926569006207 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 926569006208 trimerization site [polypeptide binding]; other site 926569006209 active site 926569006210 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926569006211 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 926569006212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569006213 catalytic residue [active] 926569006214 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 926569006215 FeS assembly protein SufD; Region: sufD; TIGR01981 926569006216 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 926569006217 FeS assembly protein SufB; Region: sufB; TIGR01980 926569006218 FeS assembly ATPase SufC; Region: sufC; TIGR01978 926569006219 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 926569006220 Walker A/P-loop; other site 926569006221 ATP binding site [chemical binding]; other site 926569006222 Q-loop/lid; other site 926569006223 ABC transporter signature motif; other site 926569006224 Walker B; other site 926569006225 D-loop; other site 926569006226 H-loop/switch region; other site 926569006227 Predicted transcriptional regulator [Transcription]; Region: COG2345 926569006228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569006229 putative DNA binding site [nucleotide binding]; other site 926569006230 putative Zn2+ binding site [ion binding]; other site 926569006231 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 926569006232 SCP-2 sterol transfer family; Region: SCP2; pfam02036 926569006233 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 926569006234 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 926569006235 oligomer interface [polypeptide binding]; other site 926569006236 metal binding site [ion binding]; metal-binding site 926569006237 metal binding site [ion binding]; metal-binding site 926569006238 putative Cl binding site [ion binding]; other site 926569006239 aspartate ring; other site 926569006240 basic sphincter; other site 926569006241 hydrophobic gate; other site 926569006242 periplasmic entrance; other site 926569006243 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569006244 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569006245 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926569006246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569006247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569006248 catalytic residue [active] 926569006249 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569006250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569006251 nucleotide binding site [chemical binding]; other site 926569006252 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 926569006253 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 926569006254 putative active site [active] 926569006255 catalytic residue [active] 926569006256 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 926569006257 active site 926569006258 dimer interface [polypeptide binding]; other site 926569006259 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 926569006260 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 926569006261 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 926569006262 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 926569006263 TPP-binding site [chemical binding]; other site 926569006264 dimer interface [polypeptide binding]; other site 926569006265 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926569006266 PYR/PP interface [polypeptide binding]; other site 926569006267 dimer interface [polypeptide binding]; other site 926569006268 TPP binding site [chemical binding]; other site 926569006269 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926569006270 ornithine carbamoyltransferase; Provisional; Region: PRK00779 926569006271 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926569006272 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926569006273 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 926569006274 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926569006275 inhibitor-cofactor binding pocket; inhibition site 926569006276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569006277 catalytic residue [active] 926569006278 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 926569006279 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 926569006280 domain interfaces; other site 926569006281 active site 926569006282 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 926569006283 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 926569006284 active site residue [active] 926569006285 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 926569006286 active site residue [active] 926569006287 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569006288 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 926569006289 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 926569006290 TPP-binding site [chemical binding]; other site 926569006291 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 926569006292 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 926569006293 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 926569006294 dimer interface [polypeptide binding]; other site 926569006295 PYR/PP interface [polypeptide binding]; other site 926569006296 TPP binding site [chemical binding]; other site 926569006297 substrate binding site [chemical binding]; other site 926569006298 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926569006299 Transcriptional regulators [Transcription]; Region: FadR; COG2186 926569006300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926569006301 DNA-binding site [nucleotide binding]; DNA binding site 926569006302 FCD domain; Region: FCD; pfam07729 926569006303 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 926569006304 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926569006305 intersubunit interface [polypeptide binding]; other site 926569006306 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 926569006307 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 926569006308 metal binding site [ion binding]; metal-binding site 926569006309 dimer interface [polypeptide binding]; other site 926569006310 PSP1 C-terminal conserved region; Region: PSP1; cl00770 926569006311 antiporter inner membrane protein; Provisional; Region: PRK11670 926569006312 Domain of unknown function DUF59; Region: DUF59; pfam01883 926569006313 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 926569006314 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 926569006315 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 926569006316 4Fe-4S binding domain; Region: Fer4; pfam00037 926569006317 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 926569006318 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 926569006319 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 926569006320 NADH dehydrogenase subunit D; Validated; Region: PRK06075 926569006321 NADH dehydrogenase subunit B; Validated; Region: PRK06411 926569006322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569006323 dimerization interface [polypeptide binding]; other site 926569006324 Predicted transcriptional regulator [Transcription]; Region: COG2345 926569006325 putative DNA binding site [nucleotide binding]; other site 926569006326 putative Zn2+ binding site [ion binding]; other site 926569006327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569006328 active site 926569006329 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 926569006330 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 926569006331 dimer interface [polypeptide binding]; other site 926569006332 catalytic triad [active] 926569006333 peroxidatic and resolving cysteines [active] 926569006334 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926569006335 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926569006336 putative dimer interface [polypeptide binding]; other site 926569006337 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 926569006338 Found in ATP-dependent protease La (LON); Region: LON; smart00464 926569006339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006340 Walker A motif; other site 926569006341 ATP binding site [chemical binding]; other site 926569006342 Walker B motif; other site 926569006343 arginine finger; other site 926569006344 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 926569006345 Response regulator receiver domain; Region: Response_reg; pfam00072 926569006346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569006347 active site 926569006348 phosphorylation site [posttranslational modification] 926569006349 intermolecular recognition site; other site 926569006350 dimerization interface [polypeptide binding]; other site 926569006351 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 926569006352 MPT binding site; other site 926569006353 trimer interface [polypeptide binding]; other site 926569006354 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 926569006355 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926569006356 Protein of unknown function DUF58; Region: DUF58; pfam01882 926569006357 MoxR-like ATPases [General function prediction only]; Region: COG0714 926569006358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006359 Walker A motif; other site 926569006360 ATP binding site [chemical binding]; other site 926569006361 Walker B motif; other site 926569006362 arginine finger; other site 926569006363 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 926569006364 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 926569006365 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 926569006366 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 926569006367 Putative zinc ribbon domain; Region: DUF164; pfam02591 926569006368 Part of AAA domain; Region: AAA_19; pfam13245 926569006369 NACHT domain; Region: NACHT; pfam05729 926569006370 HEAT repeats; Region: HEAT_2; pfam13646 926569006371 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 926569006372 protein binding surface [polypeptide binding]; other site 926569006373 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 926569006374 YGGT family; Region: YGGT; pfam02325 926569006375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 926569006376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926569006377 catalytic residue [active] 926569006378 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 926569006379 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 926569006380 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 926569006381 GSH binding site (G-site) [chemical binding]; other site 926569006382 C-terminal domain interface [polypeptide binding]; other site 926569006383 dimer interface [polypeptide binding]; other site 926569006384 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 926569006385 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926569006386 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569006387 catalytic residues [active] 926569006388 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 926569006389 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 926569006390 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926569006391 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 926569006392 active sites [active] 926569006393 tetramer interface [polypeptide binding]; other site 926569006394 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 926569006395 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 926569006396 SmpB-tmRNA interface; other site 926569006397 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926569006398 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569006399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569006400 catalytic residue [active] 926569006401 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926569006402 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 926569006403 nucleophile elbow; other site 926569006404 Predicted esterase [General function prediction only]; Region: COG0400 926569006405 putative hydrolase; Provisional; Region: PRK11460 926569006406 Bacterial SH3 domain; Region: SH3_3; pfam08239 926569006407 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 926569006408 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 926569006409 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 926569006410 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 926569006411 putative active site pocket [active] 926569006412 cleavage site 926569006413 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569006414 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569006415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569006416 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569006417 active site 926569006418 catalytic tetrad [active] 926569006419 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926569006420 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926569006421 active site 926569006422 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 926569006423 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 926569006424 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 926569006425 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926569006426 Walker A/P-loop; other site 926569006427 ATP binding site [chemical binding]; other site 926569006428 Q-loop/lid; other site 926569006429 ABC transporter signature motif; other site 926569006430 Walker B; other site 926569006431 D-loop; other site 926569006432 H-loop/switch region; other site 926569006433 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 926569006434 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 926569006435 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 926569006436 Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345 926569006437 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 926569006438 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 926569006439 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 926569006440 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 926569006441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569006442 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 926569006443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569006444 DNA binding residues [nucleotide binding] 926569006445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569006446 binding surface 926569006447 TPR motif; other site 926569006448 TPR repeat; Region: TPR_11; pfam13414 926569006449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569006450 TPR repeat; Region: TPR_11; pfam13414 926569006451 TPR motif; other site 926569006452 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 926569006453 active site 926569006454 multimer interface [polypeptide binding]; other site 926569006455 Probable beta-xylosidase; Provisional; Region: PLN03080 926569006456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926569006457 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926569006458 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 926569006459 dimerization interface [polypeptide binding]; other site 926569006460 putative active cleft [active] 926569006461 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 926569006462 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569006463 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 926569006464 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926569006465 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569006466 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569006467 Walker A/P-loop; other site 926569006468 ATP binding site [chemical binding]; other site 926569006469 Q-loop/lid; other site 926569006470 ABC transporter signature motif; other site 926569006471 Walker B; other site 926569006472 D-loop; other site 926569006473 H-loop/switch region; other site 926569006474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569006475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569006476 Walker A/P-loop; other site 926569006477 ATP binding site [chemical binding]; other site 926569006478 Q-loop/lid; other site 926569006479 ABC transporter signature motif; other site 926569006480 Walker B; other site 926569006481 D-loop; other site 926569006482 H-loop/switch region; other site 926569006483 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 926569006484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569006485 FtsX-like permease family; Region: FtsX; pfam02687 926569006486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569006487 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926569006488 FtsX-like permease family; Region: FtsX; pfam02687 926569006489 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926569006490 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 926569006491 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 926569006492 putative NAD(P) binding site [chemical binding]; other site 926569006493 putative substrate binding site [chemical binding]; other site 926569006494 catalytic Zn binding site [ion binding]; other site 926569006495 structural Zn binding site [ion binding]; other site 926569006496 DsrE/DsrF-like family; Region: DrsE; pfam02635 926569006497 Clp protease; Region: CLP_protease; pfam00574 926569006498 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 926569006499 oligomer interface [polypeptide binding]; other site 926569006500 active site residues [active] 926569006501 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 926569006502 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 926569006503 substrate binding [chemical binding]; other site 926569006504 active site 926569006505 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 926569006506 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926569006507 active site 926569006508 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 926569006509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 926569006510 FOG: CBS domain [General function prediction only]; Region: COG0517 926569006511 CHASE4 domain; Region: CHASE4; pfam05228 926569006512 PAS domain; Region: PAS_9; pfam13426 926569006513 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569006514 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569006515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569006516 Zn2+ binding site [ion binding]; other site 926569006517 Mg2+ binding site [ion binding]; other site 926569006518 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 926569006519 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 926569006520 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 926569006521 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 926569006522 Cytochrome P450; Region: p450; pfam00067 926569006523 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926569006524 SPFH domain / Band 7 family; Region: Band_7; pfam01145 926569006525 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 926569006526 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 926569006527 LexA repressor; Validated; Region: PRK00215 926569006528 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 926569006529 Catalytic site [active] 926569006530 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 926569006531 L11 interface [polypeptide binding]; other site 926569006532 putative EF-Tu interaction site [polypeptide binding]; other site 926569006533 putative EF-G interaction site [polypeptide binding]; other site 926569006534 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 926569006535 23S rRNA interface [nucleotide binding]; other site 926569006536 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 926569006537 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 926569006538 mRNA/rRNA interface [nucleotide binding]; other site 926569006539 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 926569006540 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 926569006541 23S rRNA interface [nucleotide binding]; other site 926569006542 L7/L12 interface [polypeptide binding]; other site 926569006543 putative thiostrepton binding site; other site 926569006544 L25 interface [polypeptide binding]; other site 926569006545 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 926569006546 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 926569006547 putative homodimer interface [polypeptide binding]; other site 926569006548 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 926569006549 heterodimer interface [polypeptide binding]; other site 926569006550 homodimer interface [polypeptide binding]; other site 926569006551 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 926569006552 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 926569006553 elongation factor Tu; Reviewed; Region: PRK00049 926569006554 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 926569006555 G1 box; other site 926569006556 GEF interaction site [polypeptide binding]; other site 926569006557 GTP/Mg2+ binding site [chemical binding]; other site 926569006558 Switch I region; other site 926569006559 G2 box; other site 926569006560 G3 box; other site 926569006561 Switch II region; other site 926569006562 G4 box; other site 926569006563 G5 box; other site 926569006564 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 926569006565 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 926569006566 Antibiotic Binding Site [chemical binding]; other site 926569006567 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926569006568 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 926569006569 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 926569006570 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926569006571 minor groove reading motif; other site 926569006572 helix-hairpin-helix signature motif; other site 926569006573 substrate binding pocket [chemical binding]; other site 926569006574 active site 926569006575 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 926569006576 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 926569006577 active site 926569006578 8-oxo-dGMP binding site [chemical binding]; other site 926569006579 nudix motif; other site 926569006580 metal binding site [ion binding]; metal-binding site 926569006581 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 926569006582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569006583 S-adenosylmethionine binding site [chemical binding]; other site 926569006584 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 926569006585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926569006586 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 926569006587 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 926569006588 DnaA N-terminal domain; Region: DnaA_N; pfam11638 926569006589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006590 Walker A motif; other site 926569006591 ATP binding site [chemical binding]; other site 926569006592 Walker B motif; other site 926569006593 arginine finger; other site 926569006594 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 926569006595 DnaA box-binding interface [nucleotide binding]; other site 926569006596 hypothetical protein; Provisional; Region: PRK07233 926569006597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569006598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926569006599 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569006600 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 926569006601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569006602 FeS/SAM binding site; other site 926569006603 stage V sporulation protein K; Region: spore_V_K; TIGR02881 926569006604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006605 Walker A motif; other site 926569006606 ATP binding site [chemical binding]; other site 926569006607 Walker B motif; other site 926569006608 arginine finger; other site 926569006609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006610 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569006611 Walker A motif; other site 926569006612 ATP binding site [chemical binding]; other site 926569006613 Walker B motif; other site 926569006614 arginine finger; other site 926569006615 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926569006616 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569006617 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926569006618 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 926569006619 Catalytic site [active] 926569006620 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 926569006621 intersubunit interface [polypeptide binding]; other site 926569006622 active site 926569006623 catalytic residue [active] 926569006624 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 926569006625 Zn binding site [ion binding]; other site 926569006626 toxin interface [polypeptide binding]; other site 926569006627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 926569006628 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 926569006629 Homeodomain-like domain; Region: HTH_23; pfam13384 926569006630 triosephosphate isomerase; Provisional; Region: PRK14567 926569006631 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 926569006632 substrate binding site [chemical binding]; other site 926569006633 dimer interface [polypeptide binding]; other site 926569006634 catalytic triad [active] 926569006635 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 926569006636 PA14 domain; Region: PA14; cl08459 926569006637 PA14 domain; Region: PA14; cl08459 926569006638 PAS domain; Region: PAS; smart00091 926569006639 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 926569006640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569006641 dimer interface [polypeptide binding]; other site 926569006642 phosphorylation site [posttranslational modification] 926569006643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569006644 ATP binding site [chemical binding]; other site 926569006645 Mg2+ binding site [ion binding]; other site 926569006646 G-X-G motif; other site 926569006647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569006649 active site 926569006650 phosphorylation site [posttranslational modification] 926569006651 intermolecular recognition site; other site 926569006652 dimerization interface [polypeptide binding]; other site 926569006653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569006654 DNA binding site [nucleotide binding] 926569006655 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 926569006656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926569006657 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 926569006658 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 926569006659 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 926569006660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926569006661 Walker A/P-loop; other site 926569006662 ATP binding site [chemical binding]; other site 926569006663 Q-loop/lid; other site 926569006664 ABC transporter signature motif; other site 926569006665 Walker B; other site 926569006666 D-loop; other site 926569006667 H-loop/switch region; other site 926569006668 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926569006669 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926569006670 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569006671 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569006672 Double zinc ribbon; Region: DZR; pfam12773 926569006673 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926569006674 MarC family integral membrane protein; Region: MarC; cl00919 926569006675 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926569006676 catalytic residues [active] 926569006677 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 926569006678 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 926569006679 Peptidase family M28; Region: Peptidase_M28; pfam04389 926569006680 metal binding site [ion binding]; metal-binding site 926569006681 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 926569006682 CcmE; Region: CcmE; cl00994 926569006683 transcriptional activator RfaH; Region: RfaH; TIGR01955 926569006684 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 926569006685 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 926569006686 heterodimer interface [polypeptide binding]; other site 926569006687 homodimer interface [polypeptide binding]; other site 926569006688 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 926569006689 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 926569006690 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 926569006691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926569006692 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926569006693 active site 926569006694 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926569006695 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569006696 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569006697 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 926569006698 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 926569006699 RNB domain; Region: RNB; pfam00773 926569006700 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569006701 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569006702 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 926569006703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569006704 motif II; other site 926569006705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 926569006706 putative active site [active] 926569006707 heme pocket [chemical binding]; other site 926569006708 GAF domain; Region: GAF; cl17456 926569006709 GAF domain; Region: GAF; cl17456 926569006710 MoxR-like ATPases [General function prediction only]; Region: COG0714 926569006711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 926569006712 Walker B motif; other site 926569006713 arginine finger; other site 926569006714 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926569006715 Protein of unknown function DUF58; Region: DUF58; pfam01882 926569006716 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 926569006717 hypothetical protein; Provisional; Region: PRK06446 926569006718 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 926569006719 metal binding site [ion binding]; metal-binding site 926569006720 dimer interface [polypeptide binding]; other site 926569006721 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 926569006722 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 926569006723 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 926569006724 ATP-binding site [chemical binding]; other site 926569006725 Sugar specificity; other site 926569006726 Pyrimidine base specificity; other site 926569006727 Esterase/lipase [General function prediction only]; Region: COG1647 926569006728 AhpC/TSA family; Region: AhpC-TSA; pfam00578 926569006729 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926569006730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926569006731 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 926569006732 Serine hydrolase (FSH1); Region: FSH1; pfam03959 926569006733 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926569006734 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 926569006735 nucleophilic elbow; other site 926569006736 catalytic triad; other site 926569006737 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 926569006738 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 926569006739 Part of AAA domain; Region: AAA_19; pfam13245 926569006740 Family description; Region: UvrD_C_2; pfam13538 926569006741 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 926569006742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926569006743 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 926569006744 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 926569006745 putative active site [active] 926569006746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569006747 TPR motif; other site 926569006748 binding surface 926569006749 TPR repeat; Region: TPR_11; pfam13414 926569006750 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 926569006751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569006752 FeS/SAM binding site; other site 926569006753 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 926569006754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569006755 active site 926569006756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 926569006757 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 926569006758 Homeodomain-like domain; Region: HTH_23; pfam13384 926569006759 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 926569006760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006761 Walker A motif; other site 926569006762 ATP binding site [chemical binding]; other site 926569006763 Walker B motif; other site 926569006764 arginine finger; other site 926569006765 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 926569006766 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 926569006767 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 926569006768 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 926569006769 Fe-S cluster binding site [ion binding]; other site 926569006770 DNA binding site [nucleotide binding] 926569006771 active site 926569006772 threonine synthase; Validated; Region: PRK08197 926569006773 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 926569006774 homodimer interface [polypeptide binding]; other site 926569006775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569006776 catalytic residue [active] 926569006777 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 926569006778 diphosphomevalonate decarboxylase; Region: PLN02407 926569006779 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 926569006780 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 926569006781 active site 926569006782 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 926569006783 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 926569006784 putative substrate binding region [chemical binding]; other site 926569006785 HEAT repeats; Region: HEAT_2; pfam13646 926569006786 HEAT repeats; Region: HEAT_2; pfam13646 926569006787 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 926569006788 Acylphosphatase; Region: Acylphosphatase; pfam00708 926569006789 excinuclease ABC subunit B; Provisional; Region: PRK05298 926569006790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569006791 ATP binding site [chemical binding]; other site 926569006792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569006793 nucleotide binding region [chemical binding]; other site 926569006794 ATP-binding site [chemical binding]; other site 926569006795 Ultra-violet resistance protein B; Region: UvrB; pfam12344 926569006796 UvrB/uvrC motif; Region: UVR; pfam02151 926569006797 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926569006798 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569006799 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 926569006800 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926569006801 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 926569006802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569006803 active site 926569006804 motif I; other site 926569006805 motif II; other site 926569006806 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 926569006807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926569006808 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 926569006809 acyl-activating enzyme (AAE) consensus motif; other site 926569006810 putative AMP binding site [chemical binding]; other site 926569006811 putative active site [active] 926569006812 putative CoA binding site [chemical binding]; other site 926569006813 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 926569006814 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 926569006815 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926569006816 acyl-activating enzyme (AAE) consensus motif; other site 926569006817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926569006818 AMP binding site [chemical binding]; other site 926569006819 active site 926569006820 acyl-activating enzyme (AAE) consensus motif; other site 926569006821 CoA binding site [chemical binding]; other site 926569006822 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 926569006823 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 926569006824 active site 926569006825 dimer interface [polypeptide binding]; other site 926569006826 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 926569006827 Ligand Binding Site [chemical binding]; other site 926569006828 Molecular Tunnel; other site 926569006829 NAD synthetase; Reviewed; Region: nadE; PRK00876 926569006830 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 926569006831 homodimer interface [polypeptide binding]; other site 926569006832 NAD binding pocket [chemical binding]; other site 926569006833 ATP binding pocket [chemical binding]; other site 926569006834 Mg binding site [ion binding]; other site 926569006835 active-site loop [active] 926569006836 BNR repeat-like domain; Region: BNR_2; pfam13088 926569006837 Uncharacterized conserved protein [Function unknown]; Region: COG2006 926569006838 PQQ-like domain; Region: PQQ_2; pfam13360 926569006839 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926569006840 Trp docking motif [polypeptide binding]; other site 926569006841 active site 926569006842 Uncharacterized conserved protein [Function unknown]; Region: COG2006 926569006843 Domain of unknown function (DUF362); Region: DUF362; pfam04015 926569006844 Acyltransferase family; Region: Acyl_transf_3; pfam01757 926569006845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569006846 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926569006847 Asp-box motif; other site 926569006848 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 926569006849 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926569006850 Ligand binding site; other site 926569006851 Putative Catalytic site; other site 926569006852 DXD motif; other site 926569006853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926569006854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569006855 Coenzyme A binding pocket [chemical binding]; other site 926569006856 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926569006857 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926569006858 inhibitor-cofactor binding pocket; inhibition site 926569006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569006860 catalytic residue [active] 926569006861 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926569006862 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569006863 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926569006864 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926569006865 Walker A/P-loop; other site 926569006866 ATP binding site [chemical binding]; other site 926569006867 Q-loop/lid; other site 926569006868 ABC transporter signature motif; other site 926569006869 Walker B; other site 926569006870 D-loop; other site 926569006871 H-loop/switch region; other site 926569006872 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926569006873 putative carbohydrate binding site [chemical binding]; other site 926569006874 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 926569006875 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 926569006876 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 926569006877 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569006878 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 926569006879 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926569006880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926569006881 active site 926569006882 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 926569006883 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926569006884 active site 926569006885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569006886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569006887 NAD(P) binding site [chemical binding]; other site 926569006888 active site 926569006889 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 926569006890 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926569006891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926569006892 active site 926569006893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569006894 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569006895 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926569006896 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926569006897 Probable Catalytic site; other site 926569006898 metal-binding site 926569006899 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569006900 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 926569006901 O-Antigen ligase; Region: Wzy_C; pfam04932 926569006902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926569006903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926569006904 Probable Catalytic site; other site 926569006905 metal-binding site 926569006906 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 926569006907 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 926569006908 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 926569006909 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 926569006910 DXD motif; other site 926569006911 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926569006912 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569006913 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 926569006914 Chain length determinant protein; Region: Wzz; pfam02706 926569006915 FlxA-like protein; Region: FlxA; pfam14282 926569006916 Chain length determinant protein; Region: Wzz; cl15801 926569006917 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 926569006918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569006919 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 926569006920 putative ligand binding site [chemical binding]; other site 926569006921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569006922 dimerization interface [polypeptide binding]; other site 926569006923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569006924 dimer interface [polypeptide binding]; other site 926569006925 phosphorylation site [posttranslational modification] 926569006926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569006927 ATP binding site [chemical binding]; other site 926569006928 Mg2+ binding site [ion binding]; other site 926569006929 G-X-G motif; other site 926569006930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569006932 active site 926569006933 phosphorylation site [posttranslational modification] 926569006934 intermolecular recognition site; other site 926569006935 dimerization interface [polypeptide binding]; other site 926569006936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569006937 DNA binding site [nucleotide binding] 926569006938 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 926569006939 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 926569006940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569006941 ATP binding site [chemical binding]; other site 926569006942 putative Mg++ binding site [ion binding]; other site 926569006943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569006944 nucleotide binding region [chemical binding]; other site 926569006945 ATP-binding site [chemical binding]; other site 926569006946 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 926569006947 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 926569006948 putative active site [active] 926569006949 catalytic residue [active] 926569006950 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926569006951 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926569006952 putative acyl-acceptor binding pocket; other site 926569006953 Uncharacterized conserved protein [Function unknown]; Region: COG0062 926569006954 putative carbohydrate kinase; Provisional; Region: PRK10565 926569006955 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 926569006956 putative substrate binding site [chemical binding]; other site 926569006957 putative ATP binding site [chemical binding]; other site 926569006958 YtxH-like protein; Region: YtxH; pfam12732 926569006959 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 926569006960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926569006961 metal ion-dependent adhesion site (MIDAS); other site 926569006962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569006963 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569006964 Walker A motif; other site 926569006965 ATP binding site [chemical binding]; other site 926569006966 Walker B motif; other site 926569006967 arginine finger; other site 926569006968 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 926569006969 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 926569006970 homotetramer interface [polypeptide binding]; other site 926569006971 FMN binding site [chemical binding]; other site 926569006972 homodimer contacts [polypeptide binding]; other site 926569006973 putative active site [active] 926569006974 putative substrate binding site [chemical binding]; other site 926569006975 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926569006976 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926569006977 substrate binding pocket [chemical binding]; other site 926569006978 chain length determination region; other site 926569006979 substrate-Mg2+ binding site; other site 926569006980 catalytic residues [active] 926569006981 aspartate-rich region 1; other site 926569006982 active site lid residues [active] 926569006983 aspartate-rich region 2; other site 926569006984 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 926569006985 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926569006986 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569006987 catalytic residues [active] 926569006988 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 926569006989 active site 926569006990 Zn2+ binding site [ion binding]; other site 926569006991 acyl carrier protein; Provisional; Region: acpP; PRK00982 926569006992 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 926569006993 CoA binding domain; Region: CoA_binding; smart00881 926569006994 CoA-ligase; Region: Ligase_CoA; pfam00549 926569006995 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 926569006996 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 926569006997 CoA-ligase; Region: Ligase_CoA; pfam00549 926569006998 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 926569006999 Helix-turn-helix domain; Region: HTH_17; pfam12728 926569007000 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 926569007001 Response regulator receiver domain; Region: Response_reg; pfam00072 926569007002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569007003 active site 926569007004 phosphorylation site [posttranslational modification] 926569007005 intermolecular recognition site; other site 926569007006 dimerization interface [polypeptide binding]; other site 926569007007 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 926569007008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569007009 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 926569007010 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 926569007011 ATP binding site [chemical binding]; other site 926569007012 Walker A motif; other site 926569007013 hexamer interface [polypeptide binding]; other site 926569007014 Walker B motif; other site 926569007015 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 926569007016 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 926569007017 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 926569007018 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 926569007019 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 926569007020 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 926569007021 30S subunit binding site; other site 926569007022 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 926569007023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007024 S-adenosylmethionine binding site [chemical binding]; other site 926569007025 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 926569007026 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 926569007027 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 926569007028 Walker A/P-loop; other site 926569007029 ATP binding site [chemical binding]; other site 926569007030 Q-loop/lid; other site 926569007031 ABC transporter signature motif; other site 926569007032 Walker B; other site 926569007033 D-loop; other site 926569007034 H-loop/switch region; other site 926569007035 TOBE domain; Region: TOBE; pfam03459 926569007036 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 926569007037 MutS domain I; Region: MutS_I; pfam01624 926569007038 MutS domain II; Region: MutS_II; pfam05188 926569007039 MutS domain III; Region: MutS_III; pfam05192 926569007040 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 926569007041 Walker A/P-loop; other site 926569007042 ATP binding site [chemical binding]; other site 926569007043 Q-loop/lid; other site 926569007044 ABC transporter signature motif; other site 926569007045 Walker B; other site 926569007046 D-loop; other site 926569007047 H-loop/switch region; other site 926569007048 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 926569007049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569007050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569007051 DNA binding residues [nucleotide binding] 926569007052 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569007053 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569007054 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 926569007055 catalytic residues [active] 926569007056 Protein of unknown function DUF45; Region: DUF45; pfam01863 926569007057 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 926569007058 conserved cys residue [active] 926569007059 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 926569007060 Tic20-like protein; Region: Tic20; pfam09685 926569007061 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 926569007062 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 926569007063 putative active site [active] 926569007064 substrate binding site [chemical binding]; other site 926569007065 putative cosubstrate binding site; other site 926569007066 catalytic site [active] 926569007067 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 926569007068 substrate binding site [chemical binding]; other site 926569007069 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 926569007070 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 926569007071 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 926569007072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569007073 dimerization interface [polypeptide binding]; other site 926569007074 putative DNA binding site [nucleotide binding]; other site 926569007075 putative Zn2+ binding site [ion binding]; other site 926569007076 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926569007077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007078 S-adenosylmethionine binding site [chemical binding]; other site 926569007079 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926569007080 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926569007081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007082 S-adenosylmethionine binding site [chemical binding]; other site 926569007083 elongation factor P; Validated; Region: PRK00529 926569007084 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 926569007085 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 926569007086 RNA binding site [nucleotide binding]; other site 926569007087 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 926569007088 RNA binding site [nucleotide binding]; other site 926569007089 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 926569007090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569007091 motif II; other site 926569007092 DinB superfamily; Region: DinB_2; pfam12867 926569007093 metal-dependent hydrolase; Provisional; Region: PRK13291 926569007094 FtsH Extracellular; Region: FtsH_ext; pfam06480 926569007095 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 926569007096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569007097 Walker A motif; other site 926569007098 ATP binding site [chemical binding]; other site 926569007099 Walker B motif; other site 926569007100 arginine finger; other site 926569007101 Peptidase family M41; Region: Peptidase_M41; pfam01434 926569007102 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 926569007103 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 926569007104 acyl-activating enzyme (AAE) consensus motif; other site 926569007105 putative AMP binding site [chemical binding]; other site 926569007106 putative active site [active] 926569007107 putative CoA binding site [chemical binding]; other site 926569007108 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 926569007109 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 926569007110 hypothetical protein; Reviewed; Region: PRK12497 926569007111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569007112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569007113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926569007114 metal binding site 2 [ion binding]; metal-binding site 926569007115 putative DNA binding helix; other site 926569007116 metal binding site 1 [ion binding]; metal-binding site 926569007117 dimer interface [polypeptide binding]; other site 926569007118 structural Zn2+ binding site [ion binding]; other site 926569007119 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 926569007120 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926569007121 intersubunit interface [polypeptide binding]; other site 926569007122 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 926569007123 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 926569007124 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 926569007125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926569007126 ABC-ATPase subunit interface; other site 926569007127 dimer interface [polypeptide binding]; other site 926569007128 putative PBP binding regions; other site 926569007129 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926569007130 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569007131 nucleotide binding site [chemical binding]; other site 926569007132 Ferredoxin [Energy production and conversion]; Region: COG1146 926569007133 4Fe-4S binding domain; Region: Fer4; pfam00037 926569007134 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 926569007135 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 926569007136 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 926569007137 EamA-like transporter family; Region: EamA; pfam00892 926569007138 4-alpha-glucanotransferase; Provisional; Region: PRK14508 926569007139 glycogen synthase; Provisional; Region: glgA; PRK00654 926569007140 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 926569007141 ADP-binding pocket [chemical binding]; other site 926569007142 homodimer interface [polypeptide binding]; other site 926569007143 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 926569007144 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 926569007145 active site 926569007146 putative substrate binding pocket [chemical binding]; other site 926569007147 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 926569007148 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 926569007149 putative MPT binding site; other site 926569007150 Predicted transcriptional regulators [Transcription]; Region: COG1695 926569007151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 926569007152 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 926569007153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569007154 dimer interface [polypeptide binding]; other site 926569007155 conserved gate region; other site 926569007156 putative PBP binding loops; other site 926569007157 ABC-ATPase subunit interface; other site 926569007158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 926569007159 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 926569007160 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 926569007161 Predicted permease; Region: DUF318; cl17795 926569007162 Predicted permease; Region: DUF318; cl17795 926569007163 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 926569007164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569007165 putative substrate translocation pore; other site 926569007166 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 926569007167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569007168 active site 926569007169 Int/Topo IB signature motif; other site 926569007170 DNA binding site [nucleotide binding] 926569007171 Protein of unknown function DUF91; Region: DUF91; cl00709 926569007172 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 926569007173 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 926569007174 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 926569007175 PLD-like domain; Region: PLDc_2; pfam13091 926569007176 putative active site [active] 926569007177 catalytic site [active] 926569007178 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 926569007179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569007180 ATP binding site [chemical binding]; other site 926569007181 putative Mg++ binding site [ion binding]; other site 926569007182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569007183 nucleotide binding region [chemical binding]; other site 926569007184 ATP-binding site [chemical binding]; other site 926569007185 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 926569007186 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 926569007187 SWIM zinc finger; Region: SWIM; pfam04434 926569007188 Filamin-type immunoglobulin domains; Region: IG_FLMN; smart00557 926569007189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569007190 non-specific DNA binding site [nucleotide binding]; other site 926569007191 salt bridge; other site 926569007192 sequence-specific DNA binding site [nucleotide binding]; other site 926569007193 Domain of unknown function (DUF955); Region: DUF955; cl01076 926569007194 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 926569007195 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 926569007196 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 926569007197 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 926569007198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569007199 non-specific DNA binding site [nucleotide binding]; other site 926569007200 salt bridge; other site 926569007201 sequence-specific DNA binding site [nucleotide binding]; other site 926569007202 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 926569007203 amidase catalytic site [active] 926569007204 Zn binding residues [ion binding]; other site 926569007205 substrate binding site [chemical binding]; other site 926569007206 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 926569007207 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926569007208 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 926569007209 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 926569007210 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 926569007211 Walker A motif; other site 926569007212 ATP binding site [chemical binding]; other site 926569007213 Walker B motif; other site 926569007214 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 926569007215 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007216 P-loop; other site 926569007217 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569007218 Magnesium ion binding site [ion binding]; other site 926569007219 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 926569007220 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 926569007221 AAA-like domain; Region: AAA_10; pfam12846 926569007222 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569007223 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569007224 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569007225 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 926569007226 putative active site [active] 926569007227 homotetrameric interface [polypeptide binding]; other site 926569007228 metal binding site [ion binding]; metal-binding site 926569007229 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 926569007230 PIN domain; Region: PIN_3; cl17397 926569007231 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 926569007232 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 926569007233 putative active site [active] 926569007234 homotetrameric interface [polypeptide binding]; other site 926569007235 metal binding site [ion binding]; metal-binding site 926569007236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569007237 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 926569007238 active site 926569007239 DNA binding site [nucleotide binding] 926569007240 Int/Topo IB signature motif; other site 926569007241 GxxExxY protein; Region: GxxExxY; TIGR04256 926569007242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926569007243 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926569007244 Walker A motif; other site 926569007245 ATP binding site [chemical binding]; other site 926569007246 Walker B motif; other site 926569007247 arginine finger; other site 926569007248 Helix-turn-helix domain; Region: HTH_36; pfam13730 926569007249 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926569007250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007251 P-loop; other site 926569007252 Magnesium ion binding site [ion binding]; other site 926569007253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007254 Magnesium ion binding site [ion binding]; other site 926569007255 AAA domain; Region: AAA_31; pfam13614 926569007256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007257 P-loop; other site 926569007258 Magnesium ion binding site [ion binding]; other site 926569007259 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 926569007260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926569007261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569007262 non-specific DNA binding site [nucleotide binding]; other site 926569007263 salt bridge; other site 926569007264 sequence-specific DNA binding site [nucleotide binding]; other site 926569007265 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 926569007266 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926569007267 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926569007268 dimer interface [polypeptide binding]; other site 926569007269 ssDNA binding site [nucleotide binding]; other site 926569007270 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569007271 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 926569007272 metal binding triad [ion binding]; metal-binding site 926569007273 potential protein location (hypothetical protein ANT_21900 [Anaerolinea thermophila UNI-1]) that overlaps RNA (tRNA-L) 926569007274 chaperone protein DnaJ; Provisional; Region: PRK10767 926569007275 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 926569007276 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 926569007277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569007278 catalytic core [active] 926569007279 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926569007280 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569007281 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926569007282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569007283 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926569007284 Cation efflux family; Region: Cation_efflux; pfam01545 926569007285 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926569007286 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 926569007287 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 926569007288 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 926569007289 nickel binding site [ion binding]; other site 926569007290 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 926569007291 4Fe-4S binding domain; Region: Fer4; cl02805 926569007292 NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005 926569007293 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 926569007294 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 926569007295 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 926569007296 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 926569007297 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 926569007298 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 926569007299 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569007300 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 926569007301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 926569007302 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 926569007303 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 926569007304 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926569007305 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926569007306 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 926569007307 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 926569007308 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 926569007309 L-aspartate oxidase; Provisional; Region: PRK06175 926569007310 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 926569007311 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 926569007312 Iron-sulfur protein interface; other site 926569007313 proximal heme binding site [chemical binding]; other site 926569007314 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 926569007315 putative proximal heme binding site [chemical binding]; other site 926569007316 putative Iron-sulfur protein interface [polypeptide binding]; other site 926569007317 putative SdhD-like interface [polypeptide binding]; other site 926569007318 putative distal heme binding site [chemical binding]; other site 926569007319 Transthyretin-like family; Region: DUF290; pfam01060 926569007320 putative peptide-modifying radical SAM enzyme, Mhun_1560 family; Region: rSAM_pep_methan; TIGR04083 926569007321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569007322 FeS/SAM binding site; other site 926569007323 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 926569007324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569007325 Radical SAM superfamily; Region: Radical_SAM; pfam04055 926569007326 FeS/SAM binding site; other site 926569007327 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 926569007328 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 926569007329 SET domain; Region: SET; pfam00856 926569007330 TMAO/DMSO reductase; Reviewed; Region: PRK05363 926569007331 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 926569007332 Moco binding site; other site 926569007333 metal coordination site [ion binding]; other site 926569007334 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926569007335 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 926569007336 active site 926569007337 catalytic site [active] 926569007338 substrate binding site [chemical binding]; other site 926569007339 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 926569007340 pseudouridine synthase; Region: TIGR00093 926569007341 active site 926569007342 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 926569007343 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926569007344 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 926569007345 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 926569007346 active site 926569007347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569007348 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 926569007349 YceG-like family; Region: YceG; pfam02618 926569007350 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 926569007351 dimerization interface [polypeptide binding]; other site 926569007352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569007353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569007354 metal binding site [ion binding]; metal-binding site 926569007355 active site 926569007356 I-site; other site 926569007357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 926569007358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569007359 MFS/sugar transport protein; Region: MFS_2; pfam13347 926569007360 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 926569007361 putative active site [active] 926569007362 YdjC motif; other site 926569007363 Mg binding site [ion binding]; other site 926569007364 homodimer interface [polypeptide binding]; other site 926569007365 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 926569007366 putative active site [active] 926569007367 homotetrameric interface [polypeptide binding]; other site 926569007368 metal binding site [ion binding]; metal-binding site 926569007369 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 926569007370 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 926569007371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926569007372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926569007373 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 926569007374 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926569007375 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926569007376 dimer interface [polypeptide binding]; other site 926569007377 ssDNA binding site [nucleotide binding]; other site 926569007378 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569007379 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 926569007380 SurA N-terminal domain; Region: SurA_N_3; cl07813 926569007381 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 926569007382 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926569007383 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 926569007384 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 926569007385 Walker A/P-loop; other site 926569007386 ATP binding site [chemical binding]; other site 926569007387 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 926569007388 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 926569007389 ABC transporter signature motif; other site 926569007390 Walker B; other site 926569007391 D-loop; other site 926569007392 H-loop/switch region; other site 926569007393 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 926569007394 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 926569007395 dimerization interface [polypeptide binding]; other site 926569007396 active site 926569007397 metal binding site [ion binding]; metal-binding site 926569007398 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 926569007399 dsRNA binding site [nucleotide binding]; other site 926569007400 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 926569007401 MoaE interaction surface [polypeptide binding]; other site 926569007402 MoeB interaction surface [polypeptide binding]; other site 926569007403 thiocarboxylated glycine; other site 926569007404 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 926569007405 MoaE homodimer interface [polypeptide binding]; other site 926569007406 MoaD interaction [polypeptide binding]; other site 926569007407 active site residues [active] 926569007408 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 926569007409 trimer interface [polypeptide binding]; other site 926569007410 dimer interface [polypeptide binding]; other site 926569007411 putative active site [active] 926569007412 ScpA/B protein; Region: ScpA_ScpB; cl00598 926569007413 Protein of unknown function (DUF503); Region: DUF503; pfam04456 926569007414 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 926569007415 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 926569007416 putative NAD(P) binding site [chemical binding]; other site 926569007417 putative active site [active] 926569007418 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 926569007419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569007420 FeS/SAM binding site; other site 926569007421 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 926569007422 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 926569007423 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 926569007424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926569007425 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 926569007426 substrate binding site [chemical binding]; other site 926569007427 ATP binding site [chemical binding]; other site 926569007428 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569007429 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 926569007430 Catalytic domain of Protein Kinases; Region: PKc; cd00180 926569007431 active site 926569007432 ATP binding site [chemical binding]; other site 926569007433 substrate binding site [chemical binding]; other site 926569007434 activation loop (A-loop); other site 926569007435 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 926569007436 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569007437 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569007438 D-cysteine desulfhydrase; Validated; Region: PRK03910 926569007439 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 926569007440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569007441 catalytic residue [active] 926569007442 FemAB family; Region: FemAB; pfam02388 926569007443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926569007444 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 926569007445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926569007446 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 926569007447 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569007448 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 926569007449 NAD(P) binding site [chemical binding]; other site 926569007450 homodimer interface [polypeptide binding]; other site 926569007451 substrate binding site [chemical binding]; other site 926569007452 active site 926569007453 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926569007454 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926569007455 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569007456 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926569007457 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 926569007458 Ligand binding site; other site 926569007459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569007460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569007461 dimerization interface [polypeptide binding]; other site 926569007462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569007463 dimer interface [polypeptide binding]; other site 926569007464 phosphorylation site [posttranslational modification] 926569007465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569007466 ATP binding site [chemical binding]; other site 926569007467 Mg2+ binding site [ion binding]; other site 926569007468 G-X-G motif; other site 926569007469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569007470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569007471 active site 926569007472 phosphorylation site [posttranslational modification] 926569007473 intermolecular recognition site; other site 926569007474 dimerization interface [polypeptide binding]; other site 926569007475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569007476 DNA binding site [nucleotide binding] 926569007477 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 926569007478 homotrimer interaction site [polypeptide binding]; other site 926569007479 putative active site [active] 926569007480 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569007481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569007482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569007483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569007484 Walker A/P-loop; other site 926569007485 ATP binding site [chemical binding]; other site 926569007486 Q-loop/lid; other site 926569007487 ABC transporter signature motif; other site 926569007488 Walker B; other site 926569007489 D-loop; other site 926569007490 H-loop/switch region; other site 926569007491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569007492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569007493 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 926569007494 Walker A/P-loop; other site 926569007495 ATP binding site [chemical binding]; other site 926569007496 Q-loop/lid; other site 926569007497 ABC transporter signature motif; other site 926569007498 Walker B; other site 926569007499 D-loop; other site 926569007500 H-loop/switch region; other site 926569007501 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 926569007502 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 926569007503 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926569007504 EamA-like transporter family; Region: EamA; pfam00892 926569007505 EamA-like transporter family; Region: EamA; pfam00892 926569007506 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926569007507 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926569007508 catalytic residues [active] 926569007509 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 926569007510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569007511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569007512 putative substrate translocation pore; other site 926569007513 Bacterial PH domain; Region: DUF304; pfam03703 926569007514 Short C-terminal domain; Region: SHOCT; pfam09851 926569007515 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 926569007516 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926569007517 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 926569007518 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 926569007519 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 926569007520 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 926569007521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569007522 catalytic core [active] 926569007523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569007524 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569007525 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 926569007526 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 926569007527 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 926569007528 HIGH motif; other site 926569007529 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 926569007530 active site 926569007531 KMSKS motif; other site 926569007532 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 926569007533 tRNA binding surface [nucleotide binding]; other site 926569007534 anticodon binding site; other site 926569007535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569007536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569007537 metal binding site [ion binding]; metal-binding site 926569007538 active site 926569007539 I-site; other site 926569007540 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 926569007541 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 926569007542 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 926569007543 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 926569007544 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926569007545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926569007546 active site 926569007547 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 926569007548 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 926569007549 G-X-X-G motif; other site 926569007550 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 926569007551 RxxxH motif; other site 926569007552 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 926569007553 FOG: WD40-like repeat [Function unknown]; Region: COG1520 926569007554 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926569007555 Trp docking motif [polypeptide binding]; other site 926569007556 active site 926569007557 Haemolytic domain; Region: Haemolytic; pfam01809 926569007558 Ribonuclease P; Region: Ribonuclease_P; pfam00825 926569007559 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 926569007560 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926569007561 TrkA-N domain; Region: TrkA_N; pfam02254 926569007562 TrkA-C domain; Region: TrkA_C; pfam02080 926569007563 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926569007564 TrkA-N domain; Region: TrkA_N; pfam02254 926569007565 TrkA-C domain; Region: TrkA_C; pfam02080 926569007566 Amino acid permease; Region: AA_permease_2; pfam13520 926569007567 EDD domain protein, DegV family; Region: DegV; TIGR00762 926569007568 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 926569007569 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 926569007570 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569007571 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569007572 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 926569007573 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569007574 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569007575 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569007576 epoxyqueuosine reductase; Region: TIGR00276 926569007577 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 926569007578 HEAT repeats; Region: HEAT_2; pfam13646 926569007579 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569007580 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 926569007581 TIGR03943 family protein; Region: TIGR03943 926569007582 Predicted permeases [General function prediction only]; Region: COG0701 926569007583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569007584 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569007585 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 926569007586 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926569007587 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926569007588 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 926569007589 Uncharacterized conserved protein [Function unknown]; Region: COG1434 926569007590 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926569007591 putative active site [active] 926569007592 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 926569007593 active site 926569007594 catalytic site [active] 926569007595 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 926569007596 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569007597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569007598 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569007599 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569007600 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 926569007601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569007602 Walker A/P-loop; other site 926569007603 ATP binding site [chemical binding]; other site 926569007604 Q-loop/lid; other site 926569007605 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 926569007606 ABC transporter signature motif; other site 926569007607 Walker B; other site 926569007608 D-loop; other site 926569007609 H-loop/switch region; other site 926569007610 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 926569007611 Domain of unknown function DUF21; Region: DUF21; pfam01595 926569007612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926569007613 Transporter associated domain; Region: CorC_HlyC; smart01091 926569007614 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 926569007615 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926569007616 active site 926569007617 metal binding site [ion binding]; metal-binding site 926569007618 DNA binding site [nucleotide binding] 926569007619 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 926569007620 putative active site [active] 926569007621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569007622 binding surface 926569007623 TPR motif; other site 926569007624 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 926569007625 putative active site [active] 926569007626 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 926569007627 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 926569007628 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 926569007629 hypothetical protein; Provisional; Region: PRK04194 926569007630 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 926569007631 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 926569007632 Ligand Binding Site [chemical binding]; other site 926569007633 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 926569007634 AIR carboxylase; Region: AIRC; smart01001 926569007635 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 926569007636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569007637 FeS/SAM binding site; other site 926569007638 Predicted membrane protein [Function unknown]; Region: COG2510 926569007639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926569007640 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926569007641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926569007642 catalytic residue [active] 926569007643 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569007644 cell division protein MraZ; Reviewed; Region: PRK00326 926569007645 MraZ protein; Region: MraZ; pfam02381 926569007646 MraZ protein; Region: MraZ; pfam02381 926569007647 MraW methylase family; Region: Methyltransf_5; cl17771 926569007648 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 926569007649 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 926569007650 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926569007651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926569007652 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 926569007653 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926569007654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926569007655 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926569007656 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 926569007657 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 926569007658 Mg++ binding site [ion binding]; other site 926569007659 putative catalytic motif [active] 926569007660 putative substrate binding site [chemical binding]; other site 926569007661 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 926569007662 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926569007663 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926569007664 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926569007665 cell division protein FtsW; Region: ftsW; TIGR02614 926569007666 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 926569007667 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 926569007668 active site 926569007669 homodimer interface [polypeptide binding]; other site 926569007670 Colicin V production protein; Region: Colicin_V; pfam02674 926569007671 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 926569007672 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926569007673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926569007674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926569007675 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 926569007676 FAD binding domain; Region: FAD_binding_4; pfam01565 926569007677 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 926569007678 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 926569007679 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 926569007680 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 926569007681 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 926569007682 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 926569007683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569007684 nucleotide binding site [chemical binding]; other site 926569007685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926569007686 Cell division protein FtsA; Region: FtsA; pfam14450 926569007687 cell division protein FtsZ; Validated; Region: PRK09330 926569007688 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 926569007689 nucleotide binding site [chemical binding]; other site 926569007690 SulA interaction site; other site 926569007691 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 926569007692 ATP cone domain; Region: ATP-cone; pfam03477 926569007693 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 926569007694 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 926569007695 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 926569007696 active site 926569007697 dimer interface [polypeptide binding]; other site 926569007698 effector binding site; other site 926569007699 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 926569007700 TSCPD domain; Region: TSCPD; pfam12637 926569007701 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 926569007702 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 926569007703 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 926569007704 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926569007705 putative acyl-acceptor binding pocket; other site 926569007706 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 926569007707 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 926569007708 active site 926569007709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569007710 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 926569007711 Protein of unknown function (DUF402); Region: DUF402; pfam04167 926569007712 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926569007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569007714 Walker A/P-loop; other site 926569007715 ATP binding site [chemical binding]; other site 926569007716 Q-loop/lid; other site 926569007717 ABC transporter signature motif; other site 926569007718 Walker B; other site 926569007719 D-loop; other site 926569007720 H-loop/switch region; other site 926569007721 seryl-tRNA synthetase; Provisional; Region: PRK05431 926569007722 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 926569007723 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 926569007724 dimer interface [polypeptide binding]; other site 926569007725 active site 926569007726 motif 1; other site 926569007727 motif 2; other site 926569007728 motif 3; other site 926569007729 Protein of unknown function (DUF456); Region: DUF456; pfam04306 926569007730 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 926569007731 active site 926569007732 PHP-associated; Region: PHP_C; pfam13263 926569007733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569007734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569007735 PAS fold; Region: PAS_4; pfam08448 926569007736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569007737 putative active site [active] 926569007738 heme pocket [chemical binding]; other site 926569007739 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 926569007740 cyclase homology domain; Region: CHD; cd07302 926569007741 nucleotidyl binding site; other site 926569007742 metal binding site [ion binding]; metal-binding site 926569007743 dimer interface [polypeptide binding]; other site 926569007744 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 926569007745 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 926569007746 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 926569007747 active site 926569007748 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 926569007749 metal binding site [ion binding]; metal-binding site 926569007750 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 926569007751 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 926569007752 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 926569007753 substrate binding site [chemical binding]; other site 926569007754 glutamase interaction surface [polypeptide binding]; other site 926569007755 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 926569007756 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 926569007757 catalytic residues [active] 926569007758 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 926569007759 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 926569007760 putative active site [active] 926569007761 oxyanion strand; other site 926569007762 catalytic triad [active] 926569007763 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 926569007764 conserved cys residue [active] 926569007765 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 926569007766 putative active site pocket [active] 926569007767 4-fold oligomerization interface [polypeptide binding]; other site 926569007768 metal binding residues [ion binding]; metal-binding site 926569007769 3-fold/trimer interface [polypeptide binding]; other site 926569007770 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 926569007771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926569007772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569007773 homodimer interface [polypeptide binding]; other site 926569007774 catalytic residue [active] 926569007775 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 926569007776 histidinol dehydrogenase; Region: hisD; TIGR00069 926569007777 NAD binding site [chemical binding]; other site 926569007778 dimerization interface [polypeptide binding]; other site 926569007779 product binding site; other site 926569007780 substrate binding site [chemical binding]; other site 926569007781 zinc binding site [ion binding]; other site 926569007782 catalytic residues [active] 926569007783 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 926569007784 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 926569007785 HisG, C-terminal domain; Region: HisG_C; cl06867 926569007786 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 926569007787 putative active site [active] 926569007788 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926569007789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569007790 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569007791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569007792 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 926569007793 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 926569007794 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569007795 active site 926569007796 DNA binding site [nucleotide binding] 926569007797 Int/Topo IB signature motif; other site 926569007798 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 926569007799 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 926569007800 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569007801 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569007802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926569007803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926569007804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569007805 FeS/SAM binding site; other site 926569007806 SWIM zinc finger; Region: SWIM; pfam04434 926569007807 Filamin-type immunoglobulin domains; Region: IG_FLMN; smart00557 926569007808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569007809 non-specific DNA binding site [nucleotide binding]; other site 926569007810 salt bridge; other site 926569007811 sequence-specific DNA binding site [nucleotide binding]; other site 926569007812 Domain of unknown function (DUF955); Region: DUF955; cl01076 926569007813 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 926569007814 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 926569007815 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 926569007816 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 926569007817 substrate binding site [chemical binding]; other site 926569007818 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926569007819 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 926569007820 Clp protease; Region: CLP_protease; pfam00574 926569007821 active site 926569007822 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 926569007823 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 926569007824 Walker A motif; other site 926569007825 ATP binding site [chemical binding]; other site 926569007826 Walker B motif; other site 926569007827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926569007828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007829 P-loop; other site 926569007830 Magnesium ion binding site [ion binding]; other site 926569007831 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 926569007832 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 926569007833 AAA-like domain; Region: AAA_10; pfam12846 926569007834 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926569007835 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926569007836 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926569007837 PemK-like protein; Region: PemK; pfam02452 926569007838 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569007839 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 926569007840 active site 926569007841 DNA binding site [nucleotide binding] 926569007842 Int/Topo IB signature motif; other site 926569007843 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 926569007844 DnaA N-terminal domain; Region: DnaA_N; pfam11638 926569007845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926569007846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007847 P-loop; other site 926569007848 Magnesium ion binding site [ion binding]; other site 926569007849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926569007850 Magnesium ion binding site [ion binding]; other site 926569007851 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926569007852 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926569007853 dimer interface [polypeptide binding]; other site 926569007854 ssDNA binding site [nucleotide binding]; other site 926569007855 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926569007856 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 926569007857 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 926569007858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569007859 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 926569007860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569007861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569007862 DNA binding residues [nucleotide binding] 926569007863 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 926569007864 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 926569007865 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 926569007866 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 926569007867 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 926569007868 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 926569007869 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 926569007870 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 926569007871 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 926569007872 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 926569007873 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 926569007874 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 926569007875 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 926569007876 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 926569007877 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 926569007878 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 926569007879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569007880 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926569007881 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926569007882 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926569007883 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926569007884 Uncharacterized conserved protein [Function unknown]; Region: COG2006 926569007885 Domain of unknown function (DUF362); Region: DUF362; pfam04015 926569007886 Uncharacterized conserved protein [Function unknown]; Region: COG2006 926569007887 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 926569007888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926569007889 acyl-activating enzyme (AAE) consensus motif; other site 926569007890 active site 926569007891 AMP binding site [chemical binding]; other site 926569007892 CoA binding site [chemical binding]; other site 926569007893 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569007894 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569007895 active site 926569007896 catalytic tetrad [active] 926569007897 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 926569007898 KNTase C-terminal domain; Region: KNTase_C; pfam07827 926569007899 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 926569007900 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 926569007901 GatB domain; Region: GatB_Yqey; smart00845 926569007902 GTP-binding protein YchF; Reviewed; Region: PRK09601 926569007903 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 926569007904 G1 box; other site 926569007905 GTP/Mg2+ binding site [chemical binding]; other site 926569007906 G2 box; other site 926569007907 Switch I region; other site 926569007908 G3 box; other site 926569007909 Switch II region; other site 926569007910 G4 box; other site 926569007911 G5 box; other site 926569007912 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 926569007913 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 926569007914 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 926569007915 Moco binding site; other site 926569007916 metal coordination site [ion binding]; other site 926569007917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569007918 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569007919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569007920 GAF domain; Region: GAF_3; pfam13492 926569007921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569007922 Histidine kinase; Region: HisKA_3; pfam07730 926569007923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569007924 ATP binding site [chemical binding]; other site 926569007925 Mg2+ binding site [ion binding]; other site 926569007926 G-X-G motif; other site 926569007927 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 926569007928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007929 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 926569007930 FOG: CBS domain [General function prediction only]; Region: COG0517 926569007931 Cytochrome c; Region: Cytochrom_C; pfam00034 926569007932 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 926569007933 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 926569007934 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 926569007935 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 926569007936 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 926569007937 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 926569007938 molybdopterin cofactor binding site; other site 926569007939 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 926569007940 molybdopterin cofactor binding site; other site 926569007941 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 926569007942 heme-binding residues [chemical binding]; other site 926569007943 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926569007944 TRAM domain; Region: TRAM; pfam01938 926569007945 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 926569007946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007947 S-adenosylmethionine binding site [chemical binding]; other site 926569007948 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 926569007949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569007950 S-adenosylmethionine binding site [chemical binding]; other site 926569007951 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 926569007952 catalytic triad [active] 926569007953 putative active site [active] 926569007954 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 926569007955 PA/protease or protease-like domain interface [polypeptide binding]; other site 926569007956 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 926569007957 imidazolonepropionase; Validated; Region: PRK09356 926569007958 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 926569007959 active site 926569007960 Tubulin like; Region: Tubulin_2; pfam13809 926569007961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569007962 Zn2+ binding site [ion binding]; other site 926569007963 Mg2+ binding site [ion binding]; other site 926569007964 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 926569007965 oxidoreductase; Provisional; Region: PRK06196 926569007966 putative NAD(P) binding site [chemical binding]; other site 926569007967 active site 926569007968 monogalactosyldiacylglycerol synthase; Region: PLN02605 926569007969 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 926569007970 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569007971 Competence-damaged protein; Region: CinA; pfam02464 926569007972 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 926569007973 N- and C-terminal domain interface [polypeptide binding]; other site 926569007974 D-xylulose kinase; Region: XylB; TIGR01312 926569007975 active site 926569007976 MgATP binding site [chemical binding]; other site 926569007977 catalytic site [active] 926569007978 metal binding site [ion binding]; metal-binding site 926569007979 xylulose binding site [chemical binding]; other site 926569007980 homodimer interface [polypeptide binding]; other site 926569007981 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 926569007982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569007983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569007984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569007985 DNA binding site [nucleotide binding] 926569007986 domain linker motif; other site 926569007987 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926569007988 ligand binding site [chemical binding]; other site 926569007989 dimerization interface [polypeptide binding]; other site 926569007990 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 926569007991 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 926569007992 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 926569007993 beta-phosphoglucomutase; Region: bPGM; TIGR01990 926569007994 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926569007995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569007996 motif II; other site 926569007997 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 926569007998 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926569007999 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926569008000 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 926569008001 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926569008002 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 926569008003 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 926569008004 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 926569008005 dimer interface [polypeptide binding]; other site 926569008006 motif 1; other site 926569008007 active site 926569008008 motif 2; other site 926569008009 motif 3; other site 926569008010 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 926569008011 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 926569008012 putative tRNA-binding site [nucleotide binding]; other site 926569008013 B3/4 domain; Region: B3_4; pfam03483 926569008014 tRNA synthetase B5 domain; Region: B5; smart00874 926569008015 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 926569008016 dimer interface [polypeptide binding]; other site 926569008017 motif 1; other site 926569008018 motif 3; other site 926569008019 motif 2; other site 926569008020 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 926569008021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569008022 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 926569008023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569008024 FeS/SAM binding site; other site 926569008025 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 926569008026 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 926569008027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008028 active site 926569008029 catalytic tetrad [active] 926569008030 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 926569008031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569008032 S-adenosylmethionine binding site [chemical binding]; other site 926569008033 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 926569008034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926569008035 HSP70 interaction site [polypeptide binding]; other site 926569008036 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 926569008037 substrate binding site [polypeptide binding]; other site 926569008038 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 926569008039 Zn binding sites [ion binding]; other site 926569008040 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 926569008041 dimer interface [polypeptide binding]; other site 926569008042 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 926569008043 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 926569008044 nucleotide binding site [chemical binding]; other site 926569008045 NEF interaction site [polypeptide binding]; other site 926569008046 SBD interface [polypeptide binding]; other site 926569008047 GrpE; Region: GrpE; pfam01025 926569008048 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 926569008049 dimer interface [polypeptide binding]; other site 926569008050 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 926569008051 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 926569008052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569008054 active site 926569008055 catalytic tetrad [active] 926569008056 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 926569008057 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 926569008058 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 926569008059 G1 box; other site 926569008060 putative GEF interaction site [polypeptide binding]; other site 926569008061 GTP/Mg2+ binding site [chemical binding]; other site 926569008062 Switch I region; other site 926569008063 G2 box; other site 926569008064 G3 box; other site 926569008065 Switch II region; other site 926569008066 G4 box; other site 926569008067 G5 box; other site 926569008068 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 926569008069 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 926569008070 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 926569008071 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 926569008072 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 926569008073 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 926569008074 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 926569008075 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 926569008076 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 926569008077 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 926569008078 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 926569008079 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 926569008080 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926569008081 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926569008082 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926569008083 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926569008084 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926569008085 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926569008086 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 926569008087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569008088 Hemerythrin; Region: Hemerythrin; cd12107 926569008089 Fe binding site [ion binding]; other site 926569008090 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 926569008091 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 926569008092 MOFRL family; Region: MOFRL; pfam05161 926569008093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569008094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926569008095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926569008096 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 926569008097 L-lactate permease; Region: Lactate_perm; cl00701 926569008098 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 926569008099 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 926569008100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569008101 FeS/SAM binding site; other site 926569008102 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 926569008103 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926569008104 putative di-iron ligands [ion binding]; other site 926569008105 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 926569008106 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 926569008107 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888 926569008108 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 926569008109 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 926569008110 PLD-like domain; Region: PLDc_2; pfam13091 926569008111 putative active site [active] 926569008112 catalytic site [active] 926569008113 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 926569008114 PLD-like domain; Region: PLDc_2; pfam13091 926569008115 putative active site [active] 926569008116 catalytic site [active] 926569008117 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926569008118 active site 926569008119 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 926569008120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569008121 putative substrate translocation pore; other site 926569008122 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569008123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569008124 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 926569008125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926569008126 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 926569008127 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926569008128 RNA binding site [nucleotide binding]; other site 926569008129 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 926569008130 RNA binding site [nucleotide binding]; other site 926569008131 domain interface; other site 926569008132 CTP synthetase; Validated; Region: pyrG; PRK05380 926569008133 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 926569008134 Catalytic site [active] 926569008135 active site 926569008136 UTP binding site [chemical binding]; other site 926569008137 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 926569008138 active site 926569008139 putative oxyanion hole; other site 926569008140 catalytic triad [active] 926569008141 enolase; Provisional; Region: eno; PRK00077 926569008142 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 926569008143 dimer interface [polypeptide binding]; other site 926569008144 metal binding site [ion binding]; metal-binding site 926569008145 substrate binding pocket [chemical binding]; other site 926569008146 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926569008147 Fasciclin domain; Region: Fasciclin; pfam02469 926569008148 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926569008149 Fasciclin domain; Region: Fasciclin; pfam02469 926569008150 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926569008151 Fasciclin domain; Region: Fasciclin; pfam02469 926569008152 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926569008153 Fasciclin domain; Region: Fasciclin; pfam02469 926569008154 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926569008155 Fasciclin domain; Region: Fasciclin; pfam02469 926569008156 short chain dehydrogenase; Provisional; Region: PRK06197 926569008157 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 926569008158 putative NAD(P) binding site [chemical binding]; other site 926569008159 active site 926569008160 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 926569008161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569008162 FeS/SAM binding site; other site 926569008163 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 926569008164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569008165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569008166 metal binding site [ion binding]; metal-binding site 926569008167 active site 926569008168 I-site; other site 926569008169 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 926569008170 RNA/DNA hybrid binding site [nucleotide binding]; other site 926569008171 active site 926569008172 phosphodiesterase YaeI; Provisional; Region: PRK11340 926569008173 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 926569008174 putative active site [active] 926569008175 putative metal binding site [ion binding]; other site 926569008176 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 926569008177 GMP synthase; Reviewed; Region: guaA; PRK00074 926569008178 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 926569008179 AMP/PPi binding site [chemical binding]; other site 926569008180 candidate oxyanion hole; other site 926569008181 catalytic triad [active] 926569008182 potential glutamine specificity residues [chemical binding]; other site 926569008183 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 926569008184 ATP Binding subdomain [chemical binding]; other site 926569008185 Dimerization subdomain; other site 926569008186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569008187 active site 926569008188 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 926569008189 proposed catalytic triad [active] 926569008190 active site nucleophile [active] 926569008191 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 926569008192 hypothetical protein; Provisional; Region: PRK08609 926569008193 active site 926569008194 primer binding site [nucleotide binding]; other site 926569008195 NTP binding site [chemical binding]; other site 926569008196 metal binding triad [ion binding]; metal-binding site 926569008197 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 926569008198 active site 926569008199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008200 active site 926569008201 catalytic tetrad [active] 926569008202 FOG: CBS domain [General function prediction only]; Region: COG0517 926569008203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 926569008204 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 926569008205 Part of AAA domain; Region: AAA_19; pfam13245 926569008206 Family description; Region: UvrD_C_2; pfam13538 926569008207 Phosphotransferase enzyme family; Region: APH; pfam01636 926569008208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 926569008209 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 926569008210 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 926569008211 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926569008212 active site 926569008213 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 926569008214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569008215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569008216 DNA binding residues [nucleotide binding] 926569008217 FecR protein; Region: FecR; pfam04773 926569008218 S4 domain; Region: S4_2; cl17325 926569008219 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 926569008220 Cache domain; Region: Cache_1; pfam02743 926569008221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569008222 dimerization interface [polypeptide binding]; other site 926569008223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569008224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569008225 metal binding site [ion binding]; metal-binding site 926569008226 active site 926569008227 I-site; other site 926569008228 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 926569008229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569008230 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 926569008231 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926569008232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569008233 motif II; other site 926569008234 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569008235 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569008236 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569008237 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 926569008238 MG2 domain; Region: A2M_N; pfam01835 926569008239 Alpha-2-macroglobulin family; Region: A2M; pfam00207 926569008240 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 926569008241 surface patch; other site 926569008242 thioester region; other site 926569008243 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 926569008244 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 926569008245 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 926569008246 Uncharacterized conserved protein [Function unknown]; Region: COG3287 926569008247 FIST N domain; Region: FIST; pfam08495 926569008248 FIST C domain; Region: FIST_C; pfam10442 926569008249 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 926569008250 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926569008251 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569008253 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008254 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569008255 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569008256 GAF domain; Region: GAF_2; pfam13185 926569008257 GAF domain; Region: GAF; pfam01590 926569008258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569008259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569008260 dimer interface [polypeptide binding]; other site 926569008261 phosphorylation site [posttranslational modification] 926569008262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569008263 ATP binding site [chemical binding]; other site 926569008264 Mg2+ binding site [ion binding]; other site 926569008265 G-X-G motif; other site 926569008266 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926569008267 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 926569008268 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 926569008269 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 926569008270 Walker A/P-loop; other site 926569008271 ATP binding site [chemical binding]; other site 926569008272 Q-loop/lid; other site 926569008273 ABC transporter signature motif; other site 926569008274 Walker B; other site 926569008275 D-loop; other site 926569008276 H-loop/switch region; other site 926569008277 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 926569008278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926569008279 TAP-like protein; Region: Abhydrolase_4; pfam08386 926569008280 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569008281 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 926569008282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008283 dimer interface [polypeptide binding]; other site 926569008284 conserved gate region; other site 926569008285 putative PBP binding loops; other site 926569008286 ABC-ATPase subunit interface; other site 926569008287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569008288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008289 dimer interface [polypeptide binding]; other site 926569008290 conserved gate region; other site 926569008291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 926569008292 ABC-ATPase subunit interface; other site 926569008293 Melibiase; Region: Melibiase; pfam02065 926569008294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926569008295 DNA-binding site [nucleotide binding]; DNA binding site 926569008296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 926569008297 classical (c) SDRs; Region: SDR_c; cd05233 926569008298 NAD(P) binding site [chemical binding]; other site 926569008299 active site 926569008300 chaperone protein DnaJ; Provisional; Region: PRK10767 926569008301 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926569008302 HSP70 interaction site [polypeptide binding]; other site 926569008303 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 926569008304 substrate binding site [polypeptide binding]; other site 926569008305 dimer interface [polypeptide binding]; other site 926569008306 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926569008307 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926569008308 protein binding site [polypeptide binding]; other site 926569008309 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 926569008310 eRF1 domain 3; Region: eRF1_3; pfam03465 926569008311 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 926569008312 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 926569008313 active site 926569008314 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926569008315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569008316 active site 926569008317 integral membrane protein MviN; Region: mviN; TIGR01695 926569008318 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 926569008319 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 926569008320 putative FMN binding site [chemical binding]; other site 926569008321 NADPH bind site [chemical binding]; other site 926569008322 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569008323 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 926569008324 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 926569008325 lipoyl synthase; Provisional; Region: PRK05481 926569008326 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 926569008327 CoenzymeA binding site [chemical binding]; other site 926569008328 subunit interaction site [polypeptide binding]; other site 926569008329 PHB binding site; other site 926569008330 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 926569008331 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 926569008332 active site 926569008333 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 926569008334 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 926569008335 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 926569008336 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926569008337 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926569008338 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 926569008339 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 926569008340 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569008341 phosphopeptide binding site; other site 926569008342 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 926569008343 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 926569008344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569008345 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926569008346 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926569008347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008348 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569008349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926569008351 O-Antigen ligase; Region: Wzy_C; pfam04932 926569008352 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569008353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008355 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926569008356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926569008357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926569008358 active site 926569008359 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 926569008360 putative ADP-binding pocket [chemical binding]; other site 926569008361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008362 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 926569008363 putative ADP-binding pocket [chemical binding]; other site 926569008364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569008365 Exostosin family; Region: Exostosin; pfam03016 926569008366 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 926569008367 active site 926569008368 dimer interface [polypeptide binding]; other site 926569008369 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 926569008370 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 926569008371 Ligand Binding Site [chemical binding]; other site 926569008372 Molecular Tunnel; other site 926569008373 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926569008374 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926569008375 Walker A/P-loop; other site 926569008376 ATP binding site [chemical binding]; other site 926569008377 Q-loop/lid; other site 926569008378 ABC transporter signature motif; other site 926569008379 Walker B; other site 926569008380 D-loop; other site 926569008381 H-loop/switch region; other site 926569008382 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926569008383 putative carbohydrate binding site [chemical binding]; other site 926569008384 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926569008385 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569008386 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 926569008387 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 926569008388 generic binding surface II; other site 926569008389 generic binding surface I; other site 926569008390 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 926569008391 Divergent PAP2 family; Region: DUF212; pfam02681 926569008392 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 926569008393 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 926569008394 active site 926569008395 catalytic triad [active] 926569008396 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 926569008397 peroxiredoxin; Provisional; Region: PRK13189 926569008398 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 926569008399 dimer interface [polypeptide binding]; other site 926569008400 decamer (pentamer of dimers) interface [polypeptide binding]; other site 926569008401 catalytic triad [active] 926569008402 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 926569008403 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 926569008404 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 926569008405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 926569008406 Putative glucoamylase; Region: Glycoamylase; pfam10091 926569008407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569008408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569008409 DNA binding site [nucleotide binding] 926569008410 domain linker motif; other site 926569008411 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926569008412 dimerization interface [polypeptide binding]; other site 926569008413 ligand binding site [chemical binding]; other site 926569008414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 926569008415 Putative glucoamylase; Region: Glycoamylase; pfam10091 926569008416 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569008417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008418 dimer interface [polypeptide binding]; other site 926569008419 conserved gate region; other site 926569008420 putative PBP binding loops; other site 926569008421 ABC-ATPase subunit interface; other site 926569008422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008423 dimer interface [polypeptide binding]; other site 926569008424 conserved gate region; other site 926569008425 ABC-ATPase subunit interface; other site 926569008426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008427 TPR repeat; Region: TPR_11; pfam13414 926569008428 TPR motif; other site 926569008429 binding surface 926569008430 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 926569008431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569008432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008433 dimer interface [polypeptide binding]; other site 926569008434 conserved gate region; other site 926569008435 putative PBP binding loops; other site 926569008436 ABC-ATPase subunit interface; other site 926569008437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008438 dimer interface [polypeptide binding]; other site 926569008439 conserved gate region; other site 926569008440 putative PBP binding loops; other site 926569008441 ABC-ATPase subunit interface; other site 926569008442 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 926569008443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569008444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569008445 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569008446 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 926569008447 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 926569008448 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 926569008449 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926569008450 HlyD family secretion protein; Region: HlyD_3; pfam13437 926569008451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569008452 FtsX-like permease family; Region: FtsX; pfam02687 926569008453 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926569008454 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569008455 FtsX-like permease family; Region: FtsX; pfam02687 926569008456 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 926569008457 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 926569008458 active site 926569008459 NTP binding site [chemical binding]; other site 926569008460 metal binding triad [ion binding]; metal-binding site 926569008461 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926569008462 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 926569008463 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926569008464 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 926569008465 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 926569008466 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926569008467 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569008468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569008469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569008470 active site 926569008471 phosphorylation site [posttranslational modification] 926569008472 intermolecular recognition site; other site 926569008473 dimerization interface [polypeptide binding]; other site 926569008474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569008475 DNA binding site [nucleotide binding] 926569008476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569008477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569008478 dimerization interface [polypeptide binding]; other site 926569008479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569008480 dimer interface [polypeptide binding]; other site 926569008481 phosphorylation site [posttranslational modification] 926569008482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569008483 ATP binding site [chemical binding]; other site 926569008484 Mg2+ binding site [ion binding]; other site 926569008485 G-X-G motif; other site 926569008486 Short C-terminal domain; Region: SHOCT; pfam09851 926569008487 Short C-terminal domain; Region: SHOCT; pfam09851 926569008488 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569008489 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 926569008490 FMN binding site [chemical binding]; other site 926569008491 dimer interface [polypeptide binding]; other site 926569008492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569008494 active site 926569008495 catalytic tetrad [active] 926569008496 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926569008497 Zn binding site [ion binding]; other site 926569008498 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 926569008499 hypothetical protein; Provisional; Region: PRK09256 926569008500 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 926569008501 oligomerisation interface [polypeptide binding]; other site 926569008502 mobile loop; other site 926569008503 roof hairpin; other site 926569008504 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 926569008505 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 926569008506 ring oligomerisation interface [polypeptide binding]; other site 926569008507 ATP/Mg binding site [chemical binding]; other site 926569008508 stacking interactions; other site 926569008509 hinge regions; other site 926569008510 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 926569008511 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926569008512 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 926569008513 homodimer interaction site [polypeptide binding]; other site 926569008514 cofactor binding site; other site 926569008515 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 926569008516 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 926569008517 hydrophobic ligand binding site; other site 926569008518 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 926569008519 Bacterial transcriptional activator domain; Region: BTAD; smart01043 926569008520 Predicted ATPase [General function prediction only]; Region: COG3899 926569008521 AAA ATPase domain; Region: AAA_16; pfam13191 926569008522 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008524 TPR motif; other site 926569008525 binding surface 926569008526 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 926569008527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926569008528 active site 926569008529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008530 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569008531 active site 926569008532 catalytic tetrad [active] 926569008533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569008534 Coenzyme A binding pocket [chemical binding]; other site 926569008535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569008536 Zn2+ binding site [ion binding]; other site 926569008537 Mg2+ binding site [ion binding]; other site 926569008538 Family description; Region: DsbD_2; pfam13386 926569008539 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 926569008540 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926569008541 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926569008542 metal-binding site [ion binding] 926569008543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569008544 catalytic core [active] 926569008545 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 926569008546 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 926569008547 Uncharacterized conserved protein [Function unknown]; Region: COG1432 926569008548 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 926569008549 putative metal binding site [ion binding]; other site 926569008550 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 926569008551 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926569008552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569008553 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 926569008554 TAP-like protein; Region: Abhydrolase_4; pfam08386 926569008555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926569008556 metal binding site 2 [ion binding]; metal-binding site 926569008557 putative DNA binding helix; other site 926569008558 metal binding site 1 [ion binding]; metal-binding site 926569008559 dimer interface [polypeptide binding]; other site 926569008560 structural Zn2+ binding site [ion binding]; other site 926569008561 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 926569008562 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 926569008563 G1 box; other site 926569008564 GTP/Mg2+ binding site [chemical binding]; other site 926569008565 Switch I region; other site 926569008566 G2 box; other site 926569008567 G3 box; other site 926569008568 Switch II region; other site 926569008569 G4 box; other site 926569008570 G5 box; other site 926569008571 Nucleoside recognition; Region: Gate; pfam07670 926569008572 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 926569008573 Nucleoside recognition; Region: Gate; pfam07670 926569008574 FeoA domain; Region: FeoA; pfam04023 926569008575 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569008576 Double zinc ribbon; Region: DZR; pfam12773 926569008577 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 926569008578 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 926569008579 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 926569008580 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926569008581 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926569008582 putative dimer interface [polypeptide binding]; other site 926569008583 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926569008584 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926569008585 putative dimer interface [polypeptide binding]; other site 926569008586 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926569008587 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926569008588 putative dimer interface [polypeptide binding]; other site 926569008589 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 926569008590 adenosine deaminase; Provisional; Region: PRK09358 926569008591 active site 926569008592 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926569008593 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569008594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926569008595 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 926569008596 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 926569008597 Ligand binding site; other site 926569008598 Putative Catalytic site; other site 926569008599 DXD motif; other site 926569008600 Predicted transcriptional regulators [Transcription]; Region: COG1695 926569008601 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 926569008602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926569008603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926569008604 Walker A/P-loop; other site 926569008605 ATP binding site [chemical binding]; other site 926569008606 Q-loop/lid; other site 926569008607 ABC transporter signature motif; other site 926569008608 Walker B; other site 926569008609 D-loop; other site 926569008610 H-loop/switch region; other site 926569008611 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926569008612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926569008613 FtsX-like permease family; Region: FtsX; pfam02687 926569008614 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926569008615 FtsX-like permease family; Region: FtsX; pfam02687 926569008616 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 926569008617 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 926569008618 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 926569008619 heme binding site [chemical binding]; other site 926569008620 ferroxidase pore; other site 926569008621 ferroxidase diiron center [ion binding]; other site 926569008622 DinB superfamily; Region: DinB_2; pfam12867 926569008623 DinB family; Region: DinB; cl17821 926569008624 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 926569008625 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 926569008626 DNA polymerase III subunit beta; Validated; Region: PRK05643 926569008627 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 926569008628 putative DNA binding surface [nucleotide binding]; other site 926569008629 dimer interface [polypeptide binding]; other site 926569008630 beta-clamp/clamp loader binding surface; other site 926569008631 beta-clamp/translesion DNA polymerase binding surface; other site 926569008632 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 926569008633 ABC1 family; Region: ABC1; cl17513 926569008634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569008635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569008636 active site 926569008637 phosphorylation site [posttranslational modification] 926569008638 intermolecular recognition site; other site 926569008639 dimerization interface [polypeptide binding]; other site 926569008640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569008641 DNA binding residues [nucleotide binding] 926569008642 dimerization interface [polypeptide binding]; other site 926569008643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569008644 PAS domain; Region: PAS_9; pfam13426 926569008645 putative active site [active] 926569008646 heme pocket [chemical binding]; other site 926569008647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926569008648 Histidine kinase; Region: HisKA_3; pfam07730 926569008649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569008650 ATP binding site [chemical binding]; other site 926569008651 Mg2+ binding site [ion binding]; other site 926569008652 G-X-G motif; other site 926569008653 HEAT repeats; Region: HEAT_2; pfam13646 926569008654 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 926569008655 protein binding surface [polypeptide binding]; other site 926569008656 HEAT repeats; Region: HEAT_2; pfam13646 926569008657 HEAT repeats; Region: HEAT_2; pfam13646 926569008658 HEAT repeats; Region: HEAT_2; pfam13646 926569008659 HEAT repeats; Region: HEAT_2; pfam13646 926569008660 HEAT repeats; Region: HEAT_2; pfam13646 926569008661 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 926569008662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569008663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569008664 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569008665 Walker A/P-loop; other site 926569008666 ATP binding site [chemical binding]; other site 926569008667 Q-loop/lid; other site 926569008668 ABC transporter signature motif; other site 926569008669 Walker B; other site 926569008670 D-loop; other site 926569008671 H-loop/switch region; other site 926569008672 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 926569008673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 926569008674 putative acyl-acceptor binding pocket; other site 926569008675 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 926569008676 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 926569008677 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 926569008678 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 926569008679 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926569008680 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926569008681 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 926569008682 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 926569008683 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 926569008684 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 926569008685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 926569008686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926569008687 catalytic residue [active] 926569008688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569008689 DNA binding site [nucleotide binding] 926569008690 active site 926569008691 Int/Topo IB signature motif; other site 926569008692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926569008693 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 926569008694 DNA binding site [nucleotide binding] 926569008695 CAAX protease self-immunity; Region: Abi; pfam02517 926569008696 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 926569008697 5' RNA guide strand anchoring site; other site 926569008698 active site 926569008699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569008700 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569008701 DNA methylase; Region: N6_N4_Mtase; cl17433 926569008702 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 926569008703 active site 926569008704 dimer interfaces [polypeptide binding]; other site 926569008705 catalytic residues [active] 926569008706 Putative amidase domain; Region: Amidase_6; pfam12671 926569008707 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 926569008708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926569008709 active site 926569008710 HIGH motif; other site 926569008711 nucleotide binding site [chemical binding]; other site 926569008712 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926569008713 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 926569008714 active site 926569008715 KMSKS motif; other site 926569008716 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 926569008717 tRNA binding surface [nucleotide binding]; other site 926569008718 anticodon binding site; other site 926569008719 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 926569008720 Pex2 / Pex12 amino terminal region; Region: Pex2_Pex12; pfam04757 926569008721 CAAX protease self-immunity; Region: Abi; pfam02517 926569008722 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 926569008723 anti sigma factor interaction site; other site 926569008724 regulatory phosphorylation site [posttranslational modification]; other site 926569008725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 926569008726 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 926569008727 GAF domain; Region: GAF_3; pfam13492 926569008728 GAF domain; Region: GAF_2; pfam13185 926569008729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008730 GAF domain; Region: GAF; pfam01590 926569008731 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008732 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569008733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008734 GAF domain; Region: GAF_3; pfam13492 926569008735 GAF domain; Region: GAF_3; pfam13492 926569008736 GAF domain; Region: GAF_2; pfam13185 926569008737 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008738 GAF domain; Region: GAF_3; pfam13492 926569008739 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 926569008740 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 926569008741 potential frameshift: common BLAST hit: gi|219847404|ref|YP_002461837.1| beta-lactamase domain-containing protein 926569008742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 926569008743 PAS domain; Region: PAS_9; pfam13426 926569008744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569008745 putative active site [active] 926569008746 heme pocket [chemical binding]; other site 926569008747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569008748 PAS fold; Region: PAS_3; pfam08447 926569008749 putative active site [active] 926569008750 heme pocket [chemical binding]; other site 926569008751 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569008752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569008753 metal binding site [ion binding]; metal-binding site 926569008754 active site 926569008755 I-site; other site 926569008756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 926569008757 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926569008758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569008759 ATP binding site [chemical binding]; other site 926569008760 putative Mg++ binding site [ion binding]; other site 926569008761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926569008762 nucleotide binding region [chemical binding]; other site 926569008763 ATP-binding site [chemical binding]; other site 926569008764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008766 binding surface 926569008767 TPR motif; other site 926569008768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008770 binding surface 926569008771 TPR motif; other site 926569008772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008774 TPR motif; other site 926569008775 binding surface 926569008776 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008778 TPR motif; other site 926569008779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008780 binding surface 926569008781 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569008783 TPR motif; other site 926569008784 binding surface 926569008785 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569008787 homoserine dehydrogenase; Provisional; Region: PRK06270 926569008788 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 926569008789 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 926569008790 conserved hypothetical protein; Region: TIGR03843 926569008791 FOG: WD40-like repeat [Function unknown]; Region: COG1520 926569008792 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 926569008793 Iron-sulfur protein interface; other site 926569008794 proximal heme binding site [chemical binding]; other site 926569008795 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 926569008796 putative proximal heme binding site [chemical binding]; other site 926569008797 putative Iron-sulfur protein interface [polypeptide binding]; other site 926569008798 putative SdhD-like interface [polypeptide binding]; other site 926569008799 putative distal heme binding site [chemical binding]; other site 926569008800 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 926569008801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569008802 catalytic loop [active] 926569008803 iron binding site [ion binding]; other site 926569008804 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 926569008805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926569008806 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 926569008807 glycerol kinase; Provisional; Region: glpK; PRK00047 926569008808 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 926569008809 N- and C-terminal domain interface [polypeptide binding]; other site 926569008810 active site 926569008811 MgATP binding site [chemical binding]; other site 926569008812 catalytic site [active] 926569008813 metal binding site [ion binding]; metal-binding site 926569008814 putative homotetramer interface [polypeptide binding]; other site 926569008815 glycerol binding site [chemical binding]; other site 926569008816 homodimer interface [polypeptide binding]; other site 926569008817 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 926569008818 DsrC like protein; Region: DsrC; pfam04358 926569008819 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 926569008820 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 926569008821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926569008822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926569008823 dimerization interface [polypeptide binding]; other site 926569008824 putative DNA binding site [nucleotide binding]; other site 926569008825 putative Zn2+ binding site [ion binding]; other site 926569008826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569008827 Coenzyme A binding pocket [chemical binding]; other site 926569008828 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 926569008829 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926569008830 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 926569008831 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 926569008832 Ligand binding site; other site 926569008833 Putative Catalytic site; other site 926569008834 DXD motif; other site 926569008835 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926569008836 metal-dependent hydrolase; Provisional; Region: PRK00685 926569008837 Cytochrome c; Region: Cytochrom_C; cl11414 926569008838 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926569008839 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926569008840 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 926569008841 PBP superfamily domain; Region: PBP_like_2; cl17296 926569008842 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 926569008843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008844 dimer interface [polypeptide binding]; other site 926569008845 conserved gate region; other site 926569008846 putative PBP binding loops; other site 926569008847 ABC-ATPase subunit interface; other site 926569008848 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 926569008849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569008850 dimer interface [polypeptide binding]; other site 926569008851 conserved gate region; other site 926569008852 putative PBP binding loops; other site 926569008853 ABC-ATPase subunit interface; other site 926569008854 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 926569008855 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 926569008856 Walker A/P-loop; other site 926569008857 ATP binding site [chemical binding]; other site 926569008858 Q-loop/lid; other site 926569008859 ABC transporter signature motif; other site 926569008860 Walker B; other site 926569008861 D-loop; other site 926569008862 H-loop/switch region; other site 926569008863 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 926569008864 PhoU domain; Region: PhoU; pfam01895 926569008865 PhoU domain; Region: PhoU; pfam01895 926569008866 CHAD domain; Region: CHAD; pfam05235 926569008867 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926569008868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569008869 S-adenosylmethionine binding site [chemical binding]; other site 926569008870 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569008871 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569008872 active site 926569008873 catalytic tetrad [active] 926569008874 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 926569008875 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 926569008876 DNA binding residues [nucleotide binding] 926569008877 putative dimer interface [polypeptide binding]; other site 926569008878 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 926569008879 Peptidase family M50; Region: Peptidase_M50; pfam02163 926569008880 active site 926569008881 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 926569008882 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 926569008883 putative substrate binding region [chemical binding]; other site 926569008884 Galactose oxidase, central domain; Region: Kelch_3; cl02701 926569008885 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926569008886 Galactose oxidase, central domain; Region: Kelch_3; cl02701 926569008887 Kelch motif; Region: Kelch_6; pfam13964 926569008888 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926569008889 Bacterial PH domain; Region: DUF304; pfam03703 926569008890 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 926569008891 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 926569008892 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 926569008893 active site residue [active] 926569008894 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 926569008895 active site residue [active] 926569008896 Fe-S metabolism associated domain; Region: SufE; cl00951 926569008897 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 926569008898 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926569008899 Walker A/P-loop; other site 926569008900 ATP binding site [chemical binding]; other site 926569008901 Q-loop/lid; other site 926569008902 ABC transporter signature motif; other site 926569008903 Walker B; other site 926569008904 D-loop; other site 926569008905 H-loop/switch region; other site 926569008906 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926569008907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569008908 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569008909 TM-ABC transporter signature motif; other site 926569008910 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926569008911 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 926569008912 TM-ABC transporter signature motif; other site 926569008913 Protein of unknown function (DUF493); Region: DUF493; pfam04359 926569008914 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926569008915 EamA-like transporter family; Region: EamA; pfam00892 926569008916 EamA-like transporter family; Region: EamA; pfam00892 926569008917 Esterase/lipase [General function prediction only]; Region: COG1647 926569008918 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 926569008919 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 926569008920 putative NAD(P) binding site [chemical binding]; other site 926569008921 catalytic Zn binding site [ion binding]; other site 926569008922 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 926569008923 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 926569008924 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 926569008925 active site 926569008926 Zn binding site [ion binding]; other site 926569008927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569008928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569008929 NAD(P) binding site [chemical binding]; other site 926569008930 active site 926569008931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569008933 active site 926569008934 phosphorylation site [posttranslational modification] 926569008935 intermolecular recognition site; other site 926569008936 dimerization interface [polypeptide binding]; other site 926569008937 GAF domain; Region: GAF_3; pfam13492 926569008938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569008939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569008940 ATP binding site [chemical binding]; other site 926569008941 Mg2+ binding site [ion binding]; other site 926569008942 G-X-G motif; other site 926569008943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569008944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569008945 active site 926569008946 phosphorylation site [posttranslational modification] 926569008947 intermolecular recognition site; other site 926569008948 dimerization interface [polypeptide binding]; other site 926569008949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569008950 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569008951 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569008952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569008953 dimer interface [polypeptide binding]; other site 926569008954 phosphorylation site [posttranslational modification] 926569008955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569008956 ATP binding site [chemical binding]; other site 926569008957 Mg2+ binding site [ion binding]; other site 926569008958 G-X-G motif; other site 926569008959 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 926569008960 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 926569008961 active site 926569008962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569008963 Protein of unknown function (DUF964); Region: DUF964; cl01483 926569008964 Protein of unknown function (DUF964); Region: DUF964; pfam06133 926569008965 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 926569008966 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 926569008967 ligand binding site [chemical binding]; other site 926569008968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569008969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569008970 putative substrate translocation pore; other site 926569008971 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 926569008972 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 926569008973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569008974 Zn2+ binding site [ion binding]; other site 926569008975 Mg2+ binding site [ion binding]; other site 926569008976 Response regulator receiver domain; Region: Response_reg; pfam00072 926569008977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569008978 active site 926569008979 phosphorylation site [posttranslational modification] 926569008980 intermolecular recognition site; other site 926569008981 dimerization interface [polypeptide binding]; other site 926569008982 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 926569008983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926569008984 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569008985 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 926569008986 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926569008987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926569008988 FOG: CBS domain [General function prediction only]; Region: COG0517 926569008989 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 926569008990 S-adenosylmethionine synthetase; Validated; Region: PRK05250 926569008991 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 926569008992 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 926569008993 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 926569008994 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 926569008995 MviN-like protein; Region: MVIN; pfam03023 926569008996 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 926569008997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926569008998 active site 926569008999 metal binding site [ion binding]; metal-binding site 926569009000 homotetramer interface [polypeptide binding]; other site 926569009001 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 926569009002 HD domain; Region: HD_4; pfam13328 926569009003 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 926569009004 synthetase active site [active] 926569009005 NTP binding site [chemical binding]; other site 926569009006 metal binding site [ion binding]; metal-binding site 926569009007 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 926569009008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 926569009009 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926569009010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 926569009011 RmuC family; Region: RmuC; pfam02646 926569009012 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926569009013 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 926569009014 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 926569009015 Ca binding site [ion binding]; other site 926569009016 active site 926569009017 catalytic site [active] 926569009018 Predicted membrane protein [Function unknown]; Region: COG1470 926569009019 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 926569009020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926569009021 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926569009022 Walker A/P-loop; other site 926569009023 ATP binding site [chemical binding]; other site 926569009024 Q-loop/lid; other site 926569009025 ABC transporter signature motif; other site 926569009026 Walker B; other site 926569009027 D-loop; other site 926569009028 H-loop/switch region; other site 926569009029 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 926569009030 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 926569009031 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926569009032 hydrophobic ligand binding site; other site 926569009033 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 926569009034 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 926569009035 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 926569009036 rRNA binding site [nucleotide binding]; other site 926569009037 predicted 30S ribosome binding site; other site 926569009038 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926569009039 transmembrane helices; other site 926569009040 TrkA-C domain; Region: TrkA_C; pfam02080 926569009041 TrkA-C domain; Region: TrkA_C; pfam02080 926569009042 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926569009043 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926569009044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009045 PAS domain; Region: PAS_9; pfam13426 926569009046 putative active site [active] 926569009047 heme pocket [chemical binding]; other site 926569009048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569009049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569009050 metal binding site [ion binding]; metal-binding site 926569009051 active site 926569009052 I-site; other site 926569009053 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 926569009054 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 926569009055 putative active site [active] 926569009056 putative FMN binding site [chemical binding]; other site 926569009057 putative substrate binding site [chemical binding]; other site 926569009058 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 926569009059 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 926569009060 dimer interface [polypeptide binding]; other site 926569009061 PYR/PP interface [polypeptide binding]; other site 926569009062 TPP binding site [chemical binding]; other site 926569009063 substrate binding site [chemical binding]; other site 926569009064 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 926569009065 Domain of unknown function; Region: EKR; pfam10371 926569009066 4Fe-4S binding domain; Region: Fer4_6; pfam12837 926569009067 4Fe-4S binding domain; Region: Fer4; pfam00037 926569009068 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 926569009069 TPP-binding site [chemical binding]; other site 926569009070 dimer interface [polypeptide binding]; other site 926569009071 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 926569009072 DHH family; Region: DHH; pfam01368 926569009073 DHHA1 domain; Region: DHHA1; pfam02272 926569009074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569009075 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 926569009076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 926569009077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 926569009078 Substrate-binding site [chemical binding]; other site 926569009079 Substrate specificity [chemical binding]; other site 926569009080 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 926569009081 Thioredoxin; Region: Thioredoxin_4; pfam13462 926569009082 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 926569009083 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 926569009084 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 926569009085 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 926569009086 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 926569009087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926569009088 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 926569009089 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 926569009090 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 926569009091 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 926569009092 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 926569009093 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 926569009094 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 926569009095 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 926569009096 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 926569009097 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 926569009098 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 926569009099 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 926569009100 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 926569009101 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 926569009102 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 926569009103 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 926569009104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569009105 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 926569009106 DNA binding residues [nucleotide binding] 926569009107 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 926569009108 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 926569009109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009110 dimer interface [polypeptide binding]; other site 926569009111 conserved gate region; other site 926569009112 putative PBP binding loops; other site 926569009113 ABC-ATPase subunit interface; other site 926569009114 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 926569009115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009116 dimer interface [polypeptide binding]; other site 926569009117 conserved gate region; other site 926569009118 putative PBP binding loops; other site 926569009119 ABC-ATPase subunit interface; other site 926569009120 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926569009121 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926569009122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926569009123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926569009124 DNA binding site [nucleotide binding] 926569009125 domain linker motif; other site 926569009126 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 926569009127 putative ligand binding site [chemical binding]; other site 926569009128 putative dimerization interface [polypeptide binding]; other site 926569009129 Domain of unknown function (DUF368); Region: DUF368; pfam04018 926569009130 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 926569009131 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 926569009132 catalytic domain interface [polypeptide binding]; other site 926569009133 homodimer interface [polypeptide binding]; other site 926569009134 putative active site [active] 926569009135 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 926569009136 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 926569009137 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 926569009138 putative NAD(P) binding site [chemical binding]; other site 926569009139 active site 926569009140 putative substrate binding site [chemical binding]; other site 926569009141 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 926569009142 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 926569009143 acyl-activating enzyme (AAE) consensus motif; other site 926569009144 putative AMP binding site [chemical binding]; other site 926569009145 putative active site [active] 926569009146 putative CoA binding site [chemical binding]; other site 926569009147 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 926569009148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926569009149 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 926569009150 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 926569009151 putative ligand binding site [chemical binding]; other site 926569009152 Protein of unknown function (DUF952); Region: DUF952; pfam06108 926569009153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926569009154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009155 active site 926569009156 phosphorylation site [posttranslational modification] 926569009157 intermolecular recognition site; other site 926569009158 dimerization interface [polypeptide binding]; other site 926569009159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926569009160 DNA binding site [nucleotide binding] 926569009161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926569009162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926569009163 dimerization interface [polypeptide binding]; other site 926569009164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569009165 dimer interface [polypeptide binding]; other site 926569009166 phosphorylation site [posttranslational modification] 926569009167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569009168 ATP binding site [chemical binding]; other site 926569009169 Mg2+ binding site [ion binding]; other site 926569009170 G-X-G motif; other site 926569009171 potential frameshift: common BLAST hit: gi|148654583|ref|YP_001274788.1| potassium/proton antiporter 926569009172 TrkA-C domain; Region: TrkA_C; pfam02080 926569009173 potassium/proton antiporter; Reviewed; Region: PRK05326 926569009174 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 926569009175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569009176 putative substrate translocation pore; other site 926569009177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569009178 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 926569009179 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 926569009180 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 926569009181 DUF35 OB-fold domain; Region: DUF35; pfam01796 926569009182 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 926569009183 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 926569009184 active site 926569009185 hypothetical protein; Provisional; Region: PRK04262 926569009186 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 926569009187 dimer interface [polypeptide binding]; other site 926569009188 active site 926569009189 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 926569009190 homodimer interface [polypeptide binding]; other site 926569009191 catalytic residues [active] 926569009192 NAD binding site [chemical binding]; other site 926569009193 substrate binding pocket [chemical binding]; other site 926569009194 flexible flap; other site 926569009195 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926569009196 O-Antigen ligase; Region: Wzy_C; cl04850 926569009197 O-Antigen ligase; Region: Wzy_C; pfam04932 926569009198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569009199 TPR motif; other site 926569009200 binding surface 926569009201 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926569009202 OsmC-like protein; Region: OsmC; pfam02566 926569009203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926569009204 primosomal protein N' Region: priA; TIGR00595 926569009205 ATP binding site [chemical binding]; other site 926569009206 putative Mg++ binding site [ion binding]; other site 926569009207 helicase superfamily c-terminal domain; Region: HELICc; smart00490 926569009208 ATP-binding site [chemical binding]; other site 926569009209 DNA methylase; Region: N6_N4_Mtase; pfam01555 926569009210 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 926569009211 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 926569009212 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 926569009213 EamA-like transporter family; Region: EamA; pfam00892 926569009214 EamA-like transporter family; Region: EamA; pfam00892 926569009215 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 926569009216 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 926569009217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926569009218 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 926569009219 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 926569009220 DNA binding site [nucleotide binding] 926569009221 active site 926569009222 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 926569009223 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 926569009224 GDP-binding site [chemical binding]; other site 926569009225 ACT binding site; other site 926569009226 IMP binding site; other site 926569009227 trehalose synthase; Region: treS_nterm; TIGR02456 926569009228 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 926569009229 active site 926569009230 catalytic site [active] 926569009231 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 926569009232 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926569009233 Putative esterase; Region: Esterase; pfam00756 926569009234 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926569009235 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926569009236 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 926569009237 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 926569009238 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926569009239 metal binding site [ion binding]; metal-binding site 926569009240 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 926569009241 trimer interface [polypeptide binding]; other site 926569009242 active site 926569009243 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 926569009244 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 926569009245 ligand binding site; other site 926569009246 oligomer interface; other site 926569009247 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 926569009248 dimer interface [polypeptide binding]; other site 926569009249 N-terminal domain interface [polypeptide binding]; other site 926569009250 sulfate 1 binding site; other site 926569009251 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 926569009252 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926569009253 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 926569009254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569009255 Coenzyme A binding pocket [chemical binding]; other site 926569009256 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569009257 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 926569009258 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 926569009259 Cytochrome c552; Region: Cytochrom_C552; pfam02335 926569009260 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 926569009261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569009262 active site residue [active] 926569009263 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 926569009264 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 926569009265 Uncharacterized conserved protein [Function unknown]; Region: COG1656 926569009266 Protein of unknown function DUF82; Region: DUF82; pfam01927 926569009267 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 926569009268 4Fe-4S binding domain; Region: Fer4_5; pfam12801 926569009269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 926569009270 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 926569009271 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926569009272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926569009273 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 926569009274 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 926569009275 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926569009276 EamA-like transporter family; Region: EamA; cl17759 926569009277 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 926569009278 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 926569009279 O-Antigen ligase; Region: Wzy_C; pfam04932 926569009280 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926569009281 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569009282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569009283 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 926569009284 putative ADP-binding pocket [chemical binding]; other site 926569009285 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 926569009286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569009287 putative homodimer interface [polypeptide binding]; other site 926569009288 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926569009289 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926569009290 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926569009291 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926569009292 Walker A/P-loop; other site 926569009293 ATP binding site [chemical binding]; other site 926569009294 Q-loop/lid; other site 926569009295 ABC transporter signature motif; other site 926569009296 Walker B; other site 926569009297 D-loop; other site 926569009298 H-loop/switch region; other site 926569009299 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926569009300 putative carbohydrate binding site [chemical binding]; other site 926569009301 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569009302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 926569009303 putative homodimer interface [polypeptide binding]; other site 926569009304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569009305 S-adenosylmethionine binding site [chemical binding]; other site 926569009306 Shikimate kinase; Region: SKI; pfam01202 926569009307 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 926569009308 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 926569009309 NADP binding site [chemical binding]; other site 926569009310 active site 926569009311 putative substrate binding site [chemical binding]; other site 926569009312 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 926569009313 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 926569009314 substrate binding site; other site 926569009315 tetramer interface; other site 926569009316 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 926569009317 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 926569009318 NAD binding site [chemical binding]; other site 926569009319 substrate binding site [chemical binding]; other site 926569009320 homodimer interface [polypeptide binding]; other site 926569009321 active site 926569009322 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 926569009323 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926569009324 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926569009325 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 926569009326 Double zinc ribbon; Region: DZR; pfam12773 926569009327 HEAT repeats; Region: HEAT_2; pfam13646 926569009328 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 926569009329 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 926569009330 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569009331 active site residue [active] 926569009332 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569009333 active site residue [active] 926569009334 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569009335 active site residue [active] 926569009336 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926569009337 active site residue [active] 926569009338 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 926569009339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 926569009340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926569009341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 926569009342 dimerization interface [polypeptide binding]; other site 926569009343 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 926569009344 Dehydroquinase class II; Region: DHquinase_II; pfam01220 926569009345 trimer interface [polypeptide binding]; other site 926569009346 active site 926569009347 dimer interface [polypeptide binding]; other site 926569009348 VPS10 domain; Region: VPS10; smart00602 926569009349 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926569009350 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 926569009351 nudix motif; other site 926569009352 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 926569009353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926569009354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926569009355 DNA binding residues [nucleotide binding] 926569009356 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 926569009357 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 926569009358 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926569009359 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926569009360 catalytic residue [active] 926569009361 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 926569009362 Protein phosphatase 2C; Region: PP2C; pfam00481 926569009363 active site 926569009364 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 926569009365 phosphopeptide binding site; other site 926569009366 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 926569009367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569009368 NAD(P) binding site [chemical binding]; other site 926569009369 active site 926569009370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569009371 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 926569009372 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926569009373 Ligand binding site; other site 926569009374 Putative Catalytic site; other site 926569009375 DXD motif; other site 926569009376 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926569009377 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 926569009378 dimer interface [polypeptide binding]; other site 926569009379 catalytic triad [active] 926569009380 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 926569009381 catalytic residues [active] 926569009382 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 926569009383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569009384 FeS/SAM binding site; other site 926569009385 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569009386 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 926569009387 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 926569009388 Competence protein; Region: Competence; pfam03772 926569009389 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 926569009390 putative FMN binding site [chemical binding]; other site 926569009391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569009392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569009393 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569009394 Walker A/P-loop; other site 926569009395 ATP binding site [chemical binding]; other site 926569009396 Q-loop/lid; other site 926569009397 ABC transporter signature motif; other site 926569009398 Walker B; other site 926569009399 D-loop; other site 926569009400 H-loop/switch region; other site 926569009401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926569009402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926569009403 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926569009404 Walker A/P-loop; other site 926569009405 ATP binding site [chemical binding]; other site 926569009406 Q-loop/lid; other site 926569009407 ABC transporter signature motif; other site 926569009408 Walker B; other site 926569009409 D-loop; other site 926569009410 H-loop/switch region; other site 926569009411 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926569009412 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 926569009413 Walker A/P-loop; other site 926569009414 ATP binding site [chemical binding]; other site 926569009415 Q-loop/lid; other site 926569009416 ABC transporter signature motif; other site 926569009417 Walker B; other site 926569009418 D-loop; other site 926569009419 H-loop/switch region; other site 926569009420 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 926569009421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009422 dimer interface [polypeptide binding]; other site 926569009423 conserved gate region; other site 926569009424 putative PBP binding loops; other site 926569009425 ABC-ATPase subunit interface; other site 926569009426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009427 dimer interface [polypeptide binding]; other site 926569009428 conserved gate region; other site 926569009429 putative PBP binding loops; other site 926569009430 ABC-ATPase subunit interface; other site 926569009431 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 926569009432 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 926569009433 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 926569009434 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 926569009435 classical (c) SDRs; Region: SDR_c; cd05233 926569009436 NAD(P) binding site [chemical binding]; other site 926569009437 active site 926569009438 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 926569009439 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 926569009440 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569009441 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 926569009442 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926569009443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569009444 FeS/SAM binding site; other site 926569009445 TRAM domain; Region: TRAM; cl01282 926569009446 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 926569009447 Cytochrome P450; Region: p450; cl12078 926569009448 FOG: CBS domain [General function prediction only]; Region: COG0517 926569009449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 926569009450 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 926569009451 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 926569009452 active site 926569009453 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926569009454 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 926569009455 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 926569009456 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 926569009457 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 926569009458 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926569009459 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 926569009460 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 926569009461 dimer interface [polypeptide binding]; other site 926569009462 putative anticodon binding site; other site 926569009463 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 926569009464 motif 1; other site 926569009465 active site 926569009466 motif 2; other site 926569009467 motif 3; other site 926569009468 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 926569009469 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 926569009470 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 926569009471 GTP binding site; other site 926569009472 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 926569009473 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926569009474 catalytic loop [active] 926569009475 iron binding site [ion binding]; other site 926569009476 4Fe-4S binding domain; Region: Fer4; pfam00037 926569009477 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 926569009478 molybdopterin cofactor binding site; other site 926569009479 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 926569009480 molybdopterin cofactor binding site; other site 926569009481 formate transporter FocA; Region: formate_focA; TIGR04060 926569009482 AAA ATPase domain; Region: AAA_16; pfam13191 926569009483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926569009484 AAA ATPase domain; Region: AAA_16; pfam13191 926569009485 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 926569009486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 926569009487 DNA binding site [nucleotide binding] 926569009488 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926569009489 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 926569009490 MutS domain III; Region: MutS_III; pfam05192 926569009491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569009492 Walker A/P-loop; other site 926569009493 ATP binding site [chemical binding]; other site 926569009494 Q-loop/lid; other site 926569009495 ABC transporter signature motif; other site 926569009496 Walker B; other site 926569009497 D-loop; other site 926569009498 H-loop/switch region; other site 926569009499 Smr domain; Region: Smr; pfam01713 926569009500 Uncharacterized conserved protein [Function unknown]; Region: COG3586 926569009501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 926569009502 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 926569009503 Homeodomain-like domain; Region: HTH_23; pfam13384 926569009504 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569009505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009506 active site 926569009507 phosphorylation site [posttranslational modification] 926569009508 intermolecular recognition site; other site 926569009509 dimerization interface [polypeptide binding]; other site 926569009510 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 926569009511 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 926569009512 cell division protein ZipA; Provisional; Region: PRK03427 926569009513 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 926569009514 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 926569009515 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 926569009516 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569009517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569009518 ligand binding site [chemical binding]; other site 926569009519 flexible hinge region; other site 926569009520 Bacterial PH domain; Region: DUF304; pfam03703 926569009521 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 926569009522 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 926569009523 active site 926569009524 metal binding site [ion binding]; metal-binding site 926569009525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 926569009526 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926569009527 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926569009528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 926569009529 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 926569009530 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 926569009531 NAD(P) binding site [chemical binding]; other site 926569009532 LDH/MDH dimer interface [polypeptide binding]; other site 926569009533 substrate binding site [chemical binding]; other site 926569009534 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926569009535 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 926569009536 substrate-cofactor binding pocket; other site 926569009537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569009538 catalytic residue [active] 926569009539 Rhomboid family; Region: Rhomboid; pfam01694 926569009540 Guanylate kinase; Region: Guanylate_kin; pfam00625 926569009541 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 926569009542 catalytic site [active] 926569009543 G-X2-G-X-G-K; other site 926569009544 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 926569009545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569009546 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569009547 DNA binding residues [nucleotide binding] 926569009548 dimerization interface [polypeptide binding]; other site 926569009549 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926569009550 Kelch motif; Region: Kelch_1; pfam01344 926569009551 Kelch domain; Region: Kelch; smart00612 926569009552 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926569009553 Kelch domain; Region: Kelch; smart00612 926569009554 Kelch motif; Region: Kelch_1; pfam01344 926569009555 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926569009556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926569009557 Histidine kinase; Region: HisKA_3; pfam07730 926569009558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569009559 ATP binding site [chemical binding]; other site 926569009560 Mg2+ binding site [ion binding]; other site 926569009561 G-X-G motif; other site 926569009562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926569009563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009564 active site 926569009565 phosphorylation site [posttranslational modification] 926569009566 intermolecular recognition site; other site 926569009567 dimerization interface [polypeptide binding]; other site 926569009568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926569009569 DNA binding residues [nucleotide binding] 926569009570 dimerization interface [polypeptide binding]; other site 926569009571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926569009572 putative substrate translocation pore; other site 926569009573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926569009574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926569009575 catalytic core [active] 926569009576 alcohol dehydrogenase; Provisional; Region: PTZ00354 926569009577 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 926569009578 putative NAD(P) binding site [chemical binding]; other site 926569009579 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926569009580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926569009581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569009582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569009583 active site 926569009584 catalytic tetrad [active] 926569009585 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 926569009586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009587 GAF domain; Region: GAF; cl17456 926569009588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009589 GAF domain; Region: GAF; pfam01590 926569009590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569009591 Zn2+ binding site [ion binding]; other site 926569009592 Mg2+ binding site [ion binding]; other site 926569009593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009594 PAS domain; Region: PAS_9; pfam13426 926569009595 putative active site [active] 926569009596 heme pocket [chemical binding]; other site 926569009597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926569009598 binding surface 926569009599 TPR motif; other site 926569009600 TPR repeat; Region: TPR_11; pfam13414 926569009601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926569009602 binding surface 926569009603 TPR motif; other site 926569009604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926569009605 binding surface 926569009606 TPR motif; other site 926569009607 DNA polymerase I; Provisional; Region: PRK05755 926569009608 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 926569009609 active site 926569009610 metal binding site 1 [ion binding]; metal-binding site 926569009611 putative 5' ssDNA interaction site; other site 926569009612 metal binding site 3; metal-binding site 926569009613 metal binding site 2 [ion binding]; metal-binding site 926569009614 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 926569009615 putative DNA binding site [nucleotide binding]; other site 926569009616 putative metal binding site [ion binding]; other site 926569009617 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 926569009618 active site 926569009619 catalytic site [active] 926569009620 substrate binding site [chemical binding]; other site 926569009621 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 926569009622 active site 926569009623 DNA binding site [nucleotide binding] 926569009624 catalytic site [active] 926569009625 Response regulator receiver domain; Region: Response_reg; pfam00072 926569009626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 926569009627 phosphorylation site [posttranslational modification] 926569009628 intermolecular recognition site; other site 926569009629 Transposase IS200 like; Region: Y1_Tnp; cl00848 926569009630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 926569009631 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 926569009632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569009633 Coenzyme A binding pocket [chemical binding]; other site 926569009634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926569009635 active site 926569009636 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 926569009637 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 926569009638 RNA binding site [nucleotide binding]; other site 926569009639 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 926569009640 RNA binding site [nucleotide binding]; other site 926569009641 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 926569009642 RNA binding site [nucleotide binding]; other site 926569009643 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 926569009644 RNA binding site [nucleotide binding]; other site 926569009645 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 926569009646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926569009647 FeS/SAM binding site; other site 926569009648 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569009649 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 926569009650 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 926569009651 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 926569009652 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 926569009653 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 926569009654 NurA nuclease; Region: NurA; smart00933 926569009655 Uncharacterized conserved protein [Function unknown]; Region: COG2968 926569009656 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 926569009657 Survival protein SurE; Region: SurE; cl00448 926569009658 Transglycosylase; Region: Transgly; pfam00912 926569009659 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 926569009660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 926569009661 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 926569009662 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926569009663 catalytic residues [active] 926569009664 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 926569009665 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 926569009666 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 926569009667 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 926569009668 homodimer interface [polypeptide binding]; other site 926569009669 maltodextrin glucosidase; Provisional; Region: PRK10785 926569009670 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 926569009671 active site 926569009672 homodimer interface [polypeptide binding]; other site 926569009673 catalytic site [active] 926569009674 Aamy_C domain; Region: Aamy_C; smart00632 926569009675 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926569009676 Interdomain contacts; other site 926569009677 Cytokine receptor motif; other site 926569009678 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 926569009679 Bacterial Ig-like domain; Region: Big_5; pfam13205 926569009680 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926569009681 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 926569009682 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926569009683 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 926569009684 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 926569009685 active site 926569009686 HIGH motif; other site 926569009687 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 926569009688 KMSKS motif; other site 926569009689 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 926569009690 tRNA binding surface [nucleotide binding]; other site 926569009691 anticodon binding site; other site 926569009692 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 926569009693 putative active site [active] 926569009694 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 926569009695 CAAX protease self-immunity; Region: Abi; pfam02517 926569009696 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 926569009697 homodimer interface [polypeptide binding]; other site 926569009698 substrate-cofactor binding pocket; other site 926569009699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569009700 catalytic residue [active] 926569009701 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 926569009702 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 926569009703 Ligand Binding Site [chemical binding]; other site 926569009704 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 926569009705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569009706 Zn2+ binding site [ion binding]; other site 926569009707 Mg2+ binding site [ion binding]; other site 926569009708 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 926569009709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926569009710 non-specific DNA binding site [nucleotide binding]; other site 926569009711 salt bridge; other site 926569009712 sequence-specific DNA binding site [nucleotide binding]; other site 926569009713 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 926569009714 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 926569009715 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 926569009716 nucleotide binding site [chemical binding]; other site 926569009717 NEF interaction site [polypeptide binding]; other site 926569009718 SBD interface [polypeptide binding]; other site 926569009719 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 926569009720 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926569009721 homodimer interface [polypeptide binding]; other site 926569009722 substrate-cofactor binding pocket; other site 926569009723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926569009724 catalytic residue [active] 926569009725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 926569009726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569009727 NAD(P) binding site [chemical binding]; other site 926569009728 active site 926569009729 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 926569009730 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 926569009731 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 926569009732 active site 926569009733 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926569009734 Beta-lactamase; Region: Beta-lactamase; pfam00144 926569009735 Terminase-like family; Region: Terminase_6; pfam03237 926569009736 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 926569009737 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 926569009738 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 926569009739 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926569009740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926569009741 ligand binding site [chemical binding]; other site 926569009742 flexible hinge region; other site 926569009743 NifU-like domain; Region: NifU; cl00484 926569009744 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926569009745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926569009746 putative acyl-acceptor binding pocket; other site 926569009747 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 926569009748 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 926569009749 Protease prsW family; Region: PrsW-protease; pfam13367 926569009750 Thioredoxin; Region: Thioredoxin_4; pfam13462 926569009751 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 926569009752 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926569009753 active site 926569009754 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 926569009755 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 926569009756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009757 dimer interface [polypeptide binding]; other site 926569009758 conserved gate region; other site 926569009759 putative PBP binding loops; other site 926569009760 ABC-ATPase subunit interface; other site 926569009761 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926569009762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009763 conserved gate region; other site 926569009764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009765 putative PBP binding loops; other site 926569009766 dimer interface [polypeptide binding]; other site 926569009767 ABC-ATPase subunit interface; other site 926569009768 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926569009769 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 926569009770 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926569009771 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 926569009772 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 926569009773 DNA binding site [nucleotide binding] 926569009774 active site 926569009775 Domain of unknown function DUF87; Region: DUF87; pfam01935 926569009776 AAA-like domain; Region: AAA_10; pfam12846 926569009777 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 926569009778 Fumarase C-terminus; Region: Fumerase_C; pfam05683 926569009779 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 926569009780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 926569009781 dimerization interface [polypeptide binding]; other site 926569009782 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 926569009783 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 926569009784 Walker A/P-loop; other site 926569009785 ATP binding site [chemical binding]; other site 926569009786 Q-loop/lid; other site 926569009787 ABC transporter signature motif; other site 926569009788 Walker B; other site 926569009789 D-loop; other site 926569009790 H-loop/switch region; other site 926569009791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009792 dimer interface [polypeptide binding]; other site 926569009793 conserved gate region; other site 926569009794 putative PBP binding loops; other site 926569009795 ABC-ATPase subunit interface; other site 926569009796 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 926569009797 putative nucleotide binding site [chemical binding]; other site 926569009798 uridine monophosphate binding site [chemical binding]; other site 926569009799 homohexameric interface [polypeptide binding]; other site 926569009800 elongation factor Ts; Reviewed; Region: tsf; PRK12332 926569009801 UBA/TS-N domain; Region: UBA; pfam00627 926569009802 Elongation factor TS; Region: EF_TS; pfam00889 926569009803 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 926569009804 rRNA interaction site [nucleotide binding]; other site 926569009805 S8 interaction site; other site 926569009806 putative laminin-1 binding site; other site 926569009807 Double zinc ribbon; Region: DZR; pfam12773 926569009808 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926569009809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926569009810 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 926569009811 active site 926569009812 metal binding site [ion binding]; metal-binding site 926569009813 homotetramer interface [polypeptide binding]; other site 926569009814 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 926569009815 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 926569009816 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 926569009817 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 926569009818 Predicted permeases [General function prediction only]; Region: RarD; COG2962 926569009819 EamA-like transporter family; Region: EamA; cl17759 926569009820 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 926569009821 peptide binding site [polypeptide binding]; other site 926569009822 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 926569009823 dimer interface [polypeptide binding]; other site 926569009824 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926569009825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009826 active site 926569009827 phosphorylation site [posttranslational modification] 926569009828 intermolecular recognition site; other site 926569009829 dimerization interface [polypeptide binding]; other site 926569009830 Response regulator receiver domain; Region: Response_reg; pfam00072 926569009831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009832 active site 926569009833 phosphorylation site [posttranslational modification] 926569009834 intermolecular recognition site; other site 926569009835 dimerization interface [polypeptide binding]; other site 926569009836 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 926569009837 putative binding surface; other site 926569009838 active site 926569009839 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 926569009840 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 926569009841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569009842 ATP binding site [chemical binding]; other site 926569009843 Mg2+ binding site [ion binding]; other site 926569009844 G-X-G motif; other site 926569009845 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 926569009846 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 926569009847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 926569009848 dimer interface [polypeptide binding]; other site 926569009849 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 926569009850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 926569009851 dimer interface [polypeptide binding]; other site 926569009852 putative CheW interface [polypeptide binding]; other site 926569009853 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 926569009854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 926569009855 dimer interface [polypeptide binding]; other site 926569009856 putative CheW interface [polypeptide binding]; other site 926569009857 HEAT repeats; Region: HEAT_2; pfam13646 926569009858 HEAT repeats; Region: HEAT_2; pfam13646 926569009859 HEAT repeats; Region: HEAT_2; pfam13646 926569009860 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 926569009861 protein binding surface [polypeptide binding]; other site 926569009862 HEAT repeats; Region: HEAT_2; pfam13646 926569009863 HEAT repeats; Region: HEAT_2; pfam13646 926569009864 HEAT repeats; Region: HEAT_2; pfam13646 926569009865 HEAT repeats; Region: HEAT_2; pfam13646 926569009866 HEAT repeats; Region: HEAT_2; pfam13646 926569009867 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 926569009868 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 926569009869 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 926569009870 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 926569009871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009872 active site 926569009873 phosphorylation site [posttranslational modification] 926569009874 intermolecular recognition site; other site 926569009875 dimerization interface [polypeptide binding]; other site 926569009876 CheB methylesterase; Region: CheB_methylest; pfam01339 926569009877 Response regulator receiver domain; Region: Response_reg; pfam00072 926569009878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009879 active site 926569009880 phosphorylation site [posttranslational modification] 926569009881 intermolecular recognition site; other site 926569009882 dimerization interface [polypeptide binding]; other site 926569009883 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 926569009884 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 926569009885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009886 PAS domain; Region: PAS_9; pfam13426 926569009887 putative active site [active] 926569009888 heme pocket [chemical binding]; other site 926569009889 GAF domain; Region: GAF_2; pfam13185 926569009890 GAF domain; Region: GAF_3; pfam13492 926569009891 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009892 GAF domain; Region: GAF_3; pfam13492 926569009893 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009894 GAF domain; Region: GAF_3; pfam13492 926569009895 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009896 GAF domain; Region: GAF_3; pfam13492 926569009897 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009898 GAF domain; Region: GAF; pfam01590 926569009899 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926569009900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009901 putative active site [active] 926569009902 heme pocket [chemical binding]; other site 926569009903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926569009904 dimer interface [polypeptide binding]; other site 926569009905 phosphorylation site [posttranslational modification] 926569009906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926569009907 ATP binding site [chemical binding]; other site 926569009908 Mg2+ binding site [ion binding]; other site 926569009909 G-X-G motif; other site 926569009910 PAS fold; Region: PAS_4; pfam08448 926569009911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009912 putative active site [active] 926569009913 heme pocket [chemical binding]; other site 926569009914 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009915 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569009916 PAS fold; Region: PAS_4; pfam08448 926569009917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569009918 putative active site [active] 926569009919 heme pocket [chemical binding]; other site 926569009920 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569009921 GAF domain; Region: GAF_3; pfam13492 926569009922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569009923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569009924 metal binding site [ion binding]; metal-binding site 926569009925 active site 926569009926 I-site; other site 926569009927 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 926569009928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009929 active site 926569009930 phosphorylation site [posttranslational modification] 926569009931 intermolecular recognition site; other site 926569009932 dimerization interface [polypeptide binding]; other site 926569009933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926569009934 Zn2+ binding site [ion binding]; other site 926569009935 Mg2+ binding site [ion binding]; other site 926569009936 Response regulator receiver domain; Region: Response_reg; pfam00072 926569009937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926569009938 active site 926569009939 phosphorylation site [posttranslational modification] 926569009940 intermolecular recognition site; other site 926569009941 dimerization interface [polypeptide binding]; other site 926569009942 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 926569009943 Chemotaxis phosphatase CheX; Region: CheX; cl15816 926569009944 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 926569009945 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 926569009946 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926569009947 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 926569009948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926569009949 motif II; other site 926569009950 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 926569009951 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 926569009952 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 926569009953 active site 926569009954 substrate binding site [chemical binding]; other site 926569009955 metal binding site [ion binding]; metal-binding site 926569009956 Bacterial SH3 domain; Region: SH3_4; pfam06347 926569009957 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926569009958 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 926569009959 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926569009960 Peptidase family M23; Region: Peptidase_M23; pfam01551 926569009961 Bacterial SH3 domain; Region: SH3_3; pfam08239 926569009962 Bacterial SH3 domain homologues; Region: SH3b; smart00287 926569009963 Bacterial SH3 domain; Region: SH3_3; pfam08239 926569009964 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926569009965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569009966 Walker A/P-loop; other site 926569009967 ATP binding site [chemical binding]; other site 926569009968 Q-loop/lid; other site 926569009969 ABC transporter signature motif; other site 926569009970 Walker B; other site 926569009971 D-loop; other site 926569009972 H-loop/switch region; other site 926569009973 TOBE domain; Region: TOBE_2; pfam08402 926569009974 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926569009975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009976 dimer interface [polypeptide binding]; other site 926569009977 conserved gate region; other site 926569009978 putative PBP binding loops; other site 926569009979 ABC-ATPase subunit interface; other site 926569009980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926569009981 conserved gate region; other site 926569009982 putative PBP binding loops; other site 926569009983 ABC-ATPase subunit interface; other site 926569009984 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 926569009985 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 926569009986 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 926569009987 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 926569009988 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569009989 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569009990 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926569009991 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 926569009992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569009993 Walker A/P-loop; other site 926569009994 ATP binding site [chemical binding]; other site 926569009995 Q-loop/lid; other site 926569009996 ABC transporter signature motif; other site 926569009997 Walker B; other site 926569009998 D-loop; other site 926569009999 H-loop/switch region; other site 926569010000 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 926569010001 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 926569010002 GatB domain; Region: GatB_Yqey; smart00845 926569010003 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 926569010004 UbiA prenyltransferase family; Region: UbiA; pfam01040 926569010005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926569010006 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 926569010007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926569010008 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926569010009 S-adenosylmethionine binding site [chemical binding]; other site 926569010010 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926569010011 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926569010012 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926569010013 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926569010014 active site 926569010015 catalytic tetrad [active] 926569010016 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 926569010017 active site 926569010018 catalytic residues [active] 926569010019 metal binding site [ion binding]; metal-binding site 926569010020 recombination protein F; Reviewed; Region: recF; PRK00064 926569010021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569010022 Walker A/P-loop; other site 926569010023 ATP binding site [chemical binding]; other site 926569010024 Q-loop/lid; other site 926569010025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926569010026 ABC transporter signature motif; other site 926569010027 Walker B; other site 926569010028 D-loop; other site 926569010029 H-loop/switch region; other site 926569010030 PAS fold; Region: PAS_4; pfam08448 926569010031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569010032 putative active site [active] 926569010033 heme pocket [chemical binding]; other site 926569010034 PAS domain S-box; Region: sensory_box; TIGR00229 926569010035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926569010036 putative active site [active] 926569010037 heme pocket [chemical binding]; other site 926569010038 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926569010039 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926569010040 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 926569010041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 926569010042 metal binding site [ion binding]; metal-binding site 926569010043 active site 926569010044 I-site; other site 926569010045 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926569010046 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926569010047 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926569010048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926569010049 NAD(P) binding site [chemical binding]; other site 926569010050 active site 926569010051 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 926569010052 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926569010053 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926569010054 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926569010055 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 926569010056 Fe-S cluster binding site [ion binding]; other site 926569010057 active site 926569010058 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 926569010059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926569010060 Coenzyme A binding pocket [chemical binding]; other site 926569010061 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926569010062 Glycoprotease family; Region: Peptidase_M22; pfam00814 926569010063 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 926569010064 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 926569010065 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 926569010066 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 926569010067 urocanate hydratase; Provisional; Region: PRK05414 926569010068 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 926569010069 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 926569010070 Substrate-binding site [chemical binding]; other site 926569010071 Substrate specificity [chemical binding]; other site 926569010072 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 926569010073 active site