-- dump date   	20140618_204043
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
447217000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
447217000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
447217000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000004	Walker A motif; other site
447217000005	ATP binding site [chemical binding]; other site
447217000006	Walker B motif; other site
447217000007	arginine finger; other site
447217000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
447217000009	DnaA box-binding interface [nucleotide binding]; other site
447217000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
447217000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
447217000012	putative DNA binding surface [nucleotide binding]; other site
447217000013	dimer interface [polypeptide binding]; other site
447217000014	beta-clamp/clamp loader binding surface; other site
447217000015	beta-clamp/translesion DNA polymerase binding surface; other site
447217000016	recombination protein F; Reviewed; Region: recF; PRK00064
447217000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217000018	Walker A/P-loop; other site
447217000019	ATP binding site [chemical binding]; other site
447217000020	Q-loop/lid; other site
447217000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217000022	ABC transporter signature motif; other site
447217000023	Walker B; other site
447217000024	D-loop; other site
447217000025	H-loop/switch region; other site
447217000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
447217000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000028	ATP binding site [chemical binding]; other site
447217000029	Mg2+ binding site [ion binding]; other site
447217000030	G-X-G motif; other site
447217000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
447217000032	anchoring element; other site
447217000033	dimer interface [polypeptide binding]; other site
447217000034	ATP binding site [chemical binding]; other site
447217000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
447217000036	active site
447217000037	putative metal-binding site [ion binding]; other site
447217000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
447217000039	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
447217000040	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
447217000041	dimer interface [polypeptide binding]; other site
447217000042	active site
447217000043	CoA binding pocket [chemical binding]; other site
447217000044	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
447217000045	active site
447217000046	Zn binding site [ion binding]; other site
447217000047	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217000048	Cysteine-rich domain; Region: CCG; pfam02754
447217000049	Cysteine-rich domain; Region: CCG; pfam02754
447217000050	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
447217000051	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217000052	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
447217000053	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217000054	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
447217000055	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217000056	active site
447217000057	HIGH motif; other site
447217000058	nucleotide binding site [chemical binding]; other site
447217000059	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
447217000060	active site
447217000061	KMSKS motif; other site
447217000062	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
447217000063	tRNA binding surface [nucleotide binding]; other site
447217000064	anticodon binding site; other site
447217000065	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217000066	lipoprotein signal peptidase; Provisional; Region: PRK14773
447217000067	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
447217000068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217000069	salt bridge; other site
447217000070	non-specific DNA binding site [nucleotide binding]; other site
447217000071	sequence-specific DNA binding site [nucleotide binding]; other site
447217000072	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
447217000073	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000075	dimer interface [polypeptide binding]; other site
447217000076	phosphorylation site [posttranslational modification]
447217000077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000078	ATP binding site [chemical binding]; other site
447217000079	Mg2+ binding site [ion binding]; other site
447217000080	G-X-G motif; other site
447217000081	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217000082	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217000083	active site
447217000084	metal binding site [ion binding]; metal-binding site
447217000085	prolyl-tRNA synthetase; Provisional; Region: PRK08661
447217000086	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
447217000087	dimer interface [polypeptide binding]; other site
447217000088	motif 1; other site
447217000089	active site
447217000090	motif 2; other site
447217000091	motif 3; other site
447217000092	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
447217000093	anticodon binding site; other site
447217000094	zinc-binding site [ion binding]; other site
447217000095	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
447217000096	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
447217000097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000098	NAD(P) binding site [chemical binding]; other site
447217000099	active site
447217000100	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217000102	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
447217000103	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217000104	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217000105	dimerization interface [polypeptide binding]; other site
447217000106	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000107	dimer interface [polypeptide binding]; other site
447217000108	putative CheW interface [polypeptide binding]; other site
447217000109	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
447217000110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000111	NAD(P) binding site [chemical binding]; other site
447217000112	active site
447217000113	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
447217000114	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
447217000115	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
447217000116	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217000117	Na binding site [ion binding]; other site
447217000118	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217000119	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
447217000120	acyl-activating enzyme (AAE) consensus motif; other site
447217000121	AMP binding site [chemical binding]; other site
447217000122	active site
447217000123	CoA binding site [chemical binding]; other site
447217000124	ACT domain-containing protein [General function prediction only]; Region: COG4747
447217000125	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
447217000126	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
447217000127	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
447217000128	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217000129	acyl-activating enzyme (AAE) consensus motif; other site
447217000130	AMP binding site [chemical binding]; other site
447217000131	active site
447217000132	CoA binding site [chemical binding]; other site
447217000133	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
447217000134	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217000135	PYR/PP interface [polypeptide binding]; other site
447217000136	TPP binding site [chemical binding]; other site
447217000137	dimer interface [polypeptide binding]; other site
447217000138	substrate binding site [chemical binding]; other site
447217000139	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
447217000140	TPP-binding site; other site
447217000141	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
447217000142	butyrate kinase; Provisional; Region: PRK03011
447217000143	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
447217000144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
447217000145	DNA-binding site [nucleotide binding]; DNA binding site
447217000146	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217000147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217000148	homodimer interface [polypeptide binding]; other site
447217000149	catalytic residue [active]
447217000150	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
447217000151	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217000152	Coenzyme A binding pocket [chemical binding]; other site
447217000153	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217000154	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
447217000155	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
447217000156	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
447217000157	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
447217000158	Ligand binding site [chemical binding]; other site
447217000159	Electron transfer flavoprotein domain; Region: ETF; pfam01012
447217000160	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
447217000161	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
447217000162	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
447217000163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
447217000164	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
447217000165	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
447217000166	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217000167	EamA-like transporter family; Region: EamA; pfam00892
447217000168	EamA-like transporter family; Region: EamA; pfam00892
447217000169	MltA specific insert domain; Region: MltA; smart00925
447217000170	3D domain; Region: 3D; pfam06725
447217000171	uracil transporter; Provisional; Region: PRK10720
447217000172	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
447217000173	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
447217000174	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217000175	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217000176	RNA binding surface [nucleotide binding]; other site
447217000177	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217000178	active site
447217000179	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
447217000180	Transglycosylase; Region: Transgly; pfam00912
447217000181	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
447217000182	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217000183	dimerization interface [polypeptide binding]; other site
447217000184	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000185	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217000186	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000187	dimer interface [polypeptide binding]; other site
447217000188	putative CheW interface [polypeptide binding]; other site
447217000189	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000190	dimer interface [polypeptide binding]; other site
447217000191	putative CheW interface [polypeptide binding]; other site
447217000192	EVE domain; Region: EVE; pfam01878
447217000193	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
447217000194	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
447217000195	putative acyltransferase; Provisional; Region: PRK05790
447217000196	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217000197	dimer interface [polypeptide binding]; other site
447217000198	active site
447217000199	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
447217000200	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
447217000201	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
447217000202	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
447217000203	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
447217000204	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
447217000205	active site
447217000206	oxyanion hole [active]
447217000207	catalytic triad [active]
447217000208	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217000209	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
447217000210	inhibitor-cofactor binding pocket; inhibition site
447217000211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217000212	catalytic residue [active]
447217000213	AAA domain; Region: AAA_26; pfam13500
447217000214	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
447217000215	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
447217000216	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
447217000217	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217000218	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217000219	protein binding site [polypeptide binding]; other site
447217000220	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
447217000221	thiamine phosphate binding site [chemical binding]; other site
447217000222	active site
447217000223	pyrophosphate binding site [ion binding]; other site
447217000224	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
447217000225	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
447217000226	catalytic triad [active]
447217000227	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217000228	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
447217000229	replicative DNA helicase; Region: DnaB; TIGR00665
447217000230	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
447217000231	Walker A motif; other site
447217000232	ATP binding site [chemical binding]; other site
447217000233	Walker B motif; other site
447217000234	DNA binding loops [nucleotide binding]
447217000235	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
447217000236	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
447217000237	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217000238	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
447217000239	LrgA family; Region: LrgA; pfam03788
447217000240	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
447217000241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217000242	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217000243	dimerization interface [polypeptide binding]; other site
447217000244	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
447217000245	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
447217000246	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
447217000247	substrate binding pocket [chemical binding]; other site
447217000248	dimer interface [polypeptide binding]; other site
447217000249	inhibitor binding site; inhibition site
447217000250	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217000251	B12 binding site [chemical binding]; other site
447217000252	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
447217000253	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
447217000254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000255	FeS/SAM binding site; other site
447217000256	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
447217000257	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
447217000258	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
447217000259	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000261	dimer interface [polypeptide binding]; other site
447217000262	phosphorylation site [posttranslational modification]
447217000263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000264	ATP binding site [chemical binding]; other site
447217000265	Mg2+ binding site [ion binding]; other site
447217000266	G-X-G motif; other site
447217000267	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
447217000268	Hemerythrin; Region: Hemerythrin; cd12107
447217000269	Fe binding site [ion binding]; other site
447217000270	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
447217000271	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
447217000272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000273	FeS/SAM binding site; other site
447217000274	TRAM domain; Region: TRAM; cl01282
447217000275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
447217000276	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
447217000277	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
447217000278	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
447217000279	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
447217000280	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
447217000281	Part of AAA domain; Region: AAA_19; pfam13245
447217000282	Family description; Region: UvrD_C_2; pfam13538
447217000283	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
447217000284	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
447217000285	active site
447217000286	purine riboside binding site [chemical binding]; other site
447217000287	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
447217000288	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
447217000289	DNA binding site [nucleotide binding]
447217000290	active site
447217000291	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
447217000292	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
447217000293	ligand binding site; other site
447217000294	oligomer interface; other site
447217000295	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
447217000296	dimer interface [polypeptide binding]; other site
447217000297	N-terminal domain interface [polypeptide binding]; other site
447217000298	sulfate 1 binding site; other site
447217000299	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000301	active site
447217000302	phosphorylation site [posttranslational modification]
447217000303	intermolecular recognition site; other site
447217000304	dimerization interface [polypeptide binding]; other site
447217000305	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000306	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000307	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000308	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000309	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000310	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
447217000311	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217000312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000313	active site
447217000314	phosphorylation site [posttranslational modification]
447217000315	intermolecular recognition site; other site
447217000316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000317	Walker A motif; other site
447217000318	ATP binding site [chemical binding]; other site
447217000319	Walker B motif; other site
447217000320	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217000321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000322	dimer interface [polypeptide binding]; other site
447217000323	phosphorylation site [posttranslational modification]
447217000324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000325	ATP binding site [chemical binding]; other site
447217000326	Mg2+ binding site [ion binding]; other site
447217000327	G-X-G motif; other site
447217000328	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217000329	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217000330	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217000331	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
447217000332	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
447217000333	active site
447217000334	Zn binding site [ion binding]; other site
447217000335	rod shape-determining protein MreB; Provisional; Region: PRK13927
447217000336	MreB and similar proteins; Region: MreB_like; cd10225
447217000337	nucleotide binding site [chemical binding]; other site
447217000338	Mg binding site [ion binding]; other site
447217000339	putative protofilament interaction site [polypeptide binding]; other site
447217000340	RodZ interaction site [polypeptide binding]; other site
447217000341	rod shape-determining protein MreB; Provisional; Region: PRK13927
447217000342	MreB and similar proteins; Region: MreB_like; cd10225
447217000343	nucleotide binding site [chemical binding]; other site
447217000344	Mg binding site [ion binding]; other site
447217000345	putative protofilament interaction site [polypeptide binding]; other site
447217000346	RodZ interaction site [polypeptide binding]; other site
447217000347	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
447217000348	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217000349	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217000350	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
447217000351	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
447217000352	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217000353	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217000354	active site
447217000355	ATP binding site [chemical binding]; other site
447217000356	substrate binding site [chemical binding]; other site
447217000357	activation loop (A-loop); other site
447217000358	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
447217000359	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
447217000360	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
447217000361	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
447217000362	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
447217000363	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
447217000364	putative active site [active]
447217000365	catalytic residue [active]
447217000366	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
447217000367	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
447217000368	5S rRNA interface [nucleotide binding]; other site
447217000369	CTC domain interface [polypeptide binding]; other site
447217000370	L16 interface [polypeptide binding]; other site
447217000371	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
447217000372	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
447217000373	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217000374	active site
447217000375	regulatory protein SpoVG; Reviewed; Region: PRK13259
447217000376	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
447217000377	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
447217000378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
447217000379	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217000380	active site
447217000381	PilZ domain; Region: PilZ; pfam07238
447217000382	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
447217000383	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
447217000384	putative active site [active]
447217000385	catalytic site [active]
447217000386	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217000387	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217000388	phosphopeptide binding site; other site
447217000389	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217000390	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217000391	metal binding site [ion binding]; metal-binding site
447217000392	active site
447217000393	I-site; other site
447217000394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217000395	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217000396	putative substrate translocation pore; other site
447217000397	ADP-glucose phosphorylase; Region: PLN02643
447217000398	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
447217000399	nucleotide binding site/active site [active]
447217000400	HIT family signature motif; other site
447217000401	catalytic residue [active]
447217000402	glycogen synthase; Provisional; Region: glgA; PRK00654
447217000403	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
447217000404	ADP-binding pocket [chemical binding]; other site
447217000405	homodimer interface [polypeptide binding]; other site
447217000406	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
447217000407	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
447217000408	hydroxyglutarate oxidase; Provisional; Region: PRK11728
447217000409	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
447217000410	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217000411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217000412	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
447217000413	active site
447217000414	DNA polymerase IV; Validated; Region: PRK02406
447217000415	DNA binding site [nucleotide binding]
447217000416	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217000417	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217000418	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
447217000419	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000421	active site
447217000422	phosphorylation site [posttranslational modification]
447217000423	intermolecular recognition site; other site
447217000424	dimerization interface [polypeptide binding]; other site
447217000425	DHHA1 domain; Region: DHHA1; pfam02272
447217000426	HPr kinase/phosphorylase; Provisional; Region: PRK05428
447217000427	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
447217000428	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
447217000429	Hpr binding site; other site
447217000430	active site
447217000431	homohexamer subunit interaction site [polypeptide binding]; other site
447217000432	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
447217000433	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217000434	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
447217000435	active pocket/dimerization site; other site
447217000436	active site
447217000437	phosphorylation site [posttranslational modification]
447217000438	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
447217000439	active site
447217000440	phosphorylation site [posttranslational modification]
447217000441	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
447217000442	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
447217000443	dimerization domain swap beta strand [polypeptide binding]; other site
447217000444	regulatory protein interface [polypeptide binding]; other site
447217000445	active site
447217000446	regulatory phosphorylation site [posttranslational modification]; other site
447217000447	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
447217000448	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
447217000449	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
447217000450	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
447217000451	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
447217000452	S-adenosylmethionine synthetase; Validated; Region: PRK05250
447217000453	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
447217000454	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
447217000455	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217000456	putative DNA binding site [nucleotide binding]; other site
447217000457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217000458	S-adenosylmethionine binding site [chemical binding]; other site
447217000459	Adenosylhomocysteinase; Provisional; Region: PTZ00075
447217000460	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
447217000461	homotetramer interface [polypeptide binding]; other site
447217000462	ligand binding site [chemical binding]; other site
447217000463	catalytic site [active]
447217000464	NAD binding site [chemical binding]; other site
447217000465	Bacitracin resistance protein BacA; Region: BacA; cl00858
447217000466	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
447217000467	putative active site [active]
447217000468	putative CoA binding site [chemical binding]; other site
447217000469	nudix motif; other site
447217000470	metal binding site [ion binding]; metal-binding site
447217000471	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
447217000472	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
447217000473	Substrate binding site; other site
447217000474	Cupin domain; Region: Cupin_2; cl17218
447217000475	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
447217000476	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
447217000477	active site
447217000478	substrate binding site [chemical binding]; other site
447217000479	metal binding site [ion binding]; metal-binding site
447217000480	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
447217000481	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217000482	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217000483	Domain of unknown function (DUF814); Region: DUF814; pfam05670
447217000484	SprT-like family; Region: SprT-like; pfam10263
447217000485	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217000486	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217000487	Family of unknown function (DUF490); Region: DUF490; pfam04357
447217000488	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217000489	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
447217000490	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
447217000491	hypothetical protein; Provisional; Region: PRK07338
447217000492	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
447217000493	metal binding site [ion binding]; metal-binding site
447217000494	dimer interface [polypeptide binding]; other site
447217000495	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
447217000496	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
447217000497	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
447217000498	nucleotide binding site [chemical binding]; other site
447217000499	N-acetyl-L-glutamate binding site [chemical binding]; other site
447217000500	Sulfatase; Region: Sulfatase; cl17466
447217000501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217000503	dimer interface [polypeptide binding]; other site
447217000504	phosphorylation site [posttranslational modification]
447217000505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000506	ATP binding site [chemical binding]; other site
447217000507	Mg2+ binding site [ion binding]; other site
447217000508	G-X-G motif; other site
447217000509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217000510	S-adenosylmethionine binding site [chemical binding]; other site
447217000511	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
447217000512	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
447217000513	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
447217000514	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
447217000515	putative active site [active]
447217000516	dimerization interface [polypeptide binding]; other site
447217000517	putative tRNAtyr binding site [nucleotide binding]; other site
447217000518	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
447217000519	nucleotide binding site/active site [active]
447217000520	HIT family signature motif; other site
447217000521	catalytic residue [active]
447217000522	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
447217000523	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
447217000524	homotrimer interaction site [polypeptide binding]; other site
447217000525	active site
447217000526	prephenate dehydrogenase; Validated; Region: PRK08507
447217000527	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
447217000528	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
447217000529	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
447217000530	hinge; other site
447217000531	active site
447217000532	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
447217000533	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
447217000534	NAD(P) binding site [chemical binding]; other site
447217000535	shikimate binding site; other site
447217000536	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
447217000537	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
447217000538	Tetramer interface [polypeptide binding]; other site
447217000539	active site
447217000540	FMN-binding site [chemical binding]; other site
447217000541	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
447217000542	shikimate kinase; Reviewed; Region: aroK; PRK00131
447217000543	active site
447217000544	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
447217000545	dimer interface [polypeptide binding]; other site
447217000546	active site
447217000547	metal binding site [ion binding]; metal-binding site
447217000548	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
447217000549	Dehydroquinase class II; Region: DHquinase_II; pfam01220
447217000550	active site
447217000551	trimer interface [polypeptide binding]; other site
447217000552	dimer interface [polypeptide binding]; other site
447217000553	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
447217000554	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217000555	active site
447217000556	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217000557	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
447217000558	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
447217000559	heme binding site [chemical binding]; other site
447217000560	ferroxidase pore; other site
447217000561	ferroxidase diiron center [ion binding]; other site
447217000562	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
447217000563	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217000564	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217000565	RNA binding surface [nucleotide binding]; other site
447217000566	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217000567	active site
447217000568	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
447217000569	CoA binding domain; Region: CoA_binding; cl17356
447217000570	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
447217000571	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
447217000572	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
447217000573	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
447217000574	HflX GTPase family; Region: HflX; cd01878
447217000575	G1 box; other site
447217000576	GTP/Mg2+ binding site [chemical binding]; other site
447217000577	Switch I region; other site
447217000578	G2 box; other site
447217000579	G3 box; other site
447217000580	Switch II region; other site
447217000581	G4 box; other site
447217000582	putative sialic acid transporter; Region: 2A0112; TIGR00891
447217000583	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
447217000584	active site
447217000585	catalytic site [active]
447217000586	substrate binding site [chemical binding]; other site
447217000587	Peptidase family M48; Region: Peptidase_M48; cl12018
447217000588	gamma-glutamyl kinase; Provisional; Region: PRK05429
447217000589	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
447217000590	nucleotide binding site [chemical binding]; other site
447217000591	homotetrameric interface [polypeptide binding]; other site
447217000592	putative phosphate binding site [ion binding]; other site
447217000593	putative allosteric binding site; other site
447217000594	PUA domain; Region: PUA; cl00607
447217000595	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
447217000596	putative catalytic cysteine [active]
447217000597	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
447217000598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217000599	S-adenosylmethionine binding site [chemical binding]; other site
447217000600	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
447217000601	EamA-like transporter family; Region: EamA; pfam00892
447217000602	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217000603	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217000604	active site
447217000605	ATP binding site [chemical binding]; other site
447217000606	substrate binding site [chemical binding]; other site
447217000607	activation loop (A-loop); other site
447217000608	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
447217000609	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217000610	dimer interface [polypeptide binding]; other site
447217000611	PYR/PP interface [polypeptide binding]; other site
447217000612	TPP binding site [chemical binding]; other site
447217000613	substrate binding site [chemical binding]; other site
447217000614	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
447217000615	Domain of unknown function; Region: EKR; pfam10371
447217000616	4Fe-4S binding domain; Region: Fer4_6; pfam12837
447217000617	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
447217000618	TPP-binding site [chemical binding]; other site
447217000619	dimer interface [polypeptide binding]; other site
447217000620	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217000621	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217000622	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
447217000623	putative NAD(P) binding site [chemical binding]; other site
447217000624	active site
447217000625	putative substrate binding site [chemical binding]; other site
447217000626	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
447217000627	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217000628	putative catalytic site [active]
447217000629	putative phosphate binding site [ion binding]; other site
447217000630	putative metal binding site [ion binding]; other site
447217000631	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217000632	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217000633	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217000634	DsrE/DsrF-like family; Region: DrsE; pfam02635
447217000635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217000636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217000637	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217000638	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217000639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217000640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
447217000641	Putative zinc-finger; Region: zf-HC2; pfam13490
447217000642	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
447217000643	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
447217000644	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
447217000645	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
447217000646	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
447217000647	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
447217000648	active site
447217000649	catalytic residues [active]
447217000650	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
447217000651	phosphoglyceromutase; Provisional; Region: PRK05434
447217000652	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
447217000653	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217000654	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
447217000655	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217000656	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
447217000657	TfoX N-terminal domain; Region: TfoX_N; pfam04993
447217000658	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
447217000659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000660	FeS/SAM binding site; other site
447217000661	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217000662	putative oligopeptide transporter, OPT family; Region: TIGR00733
447217000663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000664	active site
447217000665	phosphorylation site [posttranslational modification]
447217000666	intermolecular recognition site; other site
447217000667	dimerization interface [polypeptide binding]; other site
447217000668	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
447217000669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217000670	S-adenosylmethionine binding site [chemical binding]; other site
447217000671	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
447217000672	RNA methyltransferase, RsmE family; Region: TIGR00046
447217000673	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217000674	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
447217000675	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
447217000676	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
447217000677	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217000678	DNA-binding site [nucleotide binding]; DNA binding site
447217000679	RNA-binding motif; other site
447217000680	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
447217000681	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
447217000682	FMN binding site [chemical binding]; other site
447217000683	substrate binding site [chemical binding]; other site
447217000684	putative catalytic residue [active]
447217000685	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217000686	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217000687	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217000688	putative acyl-acceptor binding pocket; other site
447217000689	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
447217000690	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000692	dimer interface [polypeptide binding]; other site
447217000693	phosphorylation site [posttranslational modification]
447217000694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000695	ATP binding site [chemical binding]; other site
447217000696	Mg2+ binding site [ion binding]; other site
447217000697	G-X-G motif; other site
447217000698	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
447217000699	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217000700	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217000701	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
447217000702	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217000703	carboxyltransferase (CT) interaction site; other site
447217000704	biotinylation site [posttranslational modification]; other site
447217000705	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
447217000706	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217000707	HSP70 interaction site [polypeptide binding]; other site
447217000708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217000709	binding surface
447217000710	TPR motif; other site
447217000711	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
447217000712	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
447217000713	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217000714	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217000715	active site
447217000716	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
447217000717	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217000718	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217000719	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217000720	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217000721	elongation factor Ts; Reviewed; Region: tsf; PRK12332
447217000722	UBA/TS-N domain; Region: UBA; pfam00627
447217000723	Elongation factor TS; Region: EF_TS; pfam00889
447217000724	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
447217000725	rRNA interaction site [nucleotide binding]; other site
447217000726	S8 interaction site; other site
447217000727	putative laminin-1 binding site; other site
447217000728	Competence protein CoiA-like family; Region: CoiA; cl11541
447217000729	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
447217000730	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217000731	catalytic triad [active]
447217000732	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
447217000733	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
447217000734	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
447217000735	DNA binding site [nucleotide binding]
447217000736	catalytic residue [active]
447217000737	H2TH interface [polypeptide binding]; other site
447217000738	putative catalytic residues [active]
447217000739	turnover-facilitating residue; other site
447217000740	intercalation triad [nucleotide binding]; other site
447217000741	8OG recognition residue [nucleotide binding]; other site
447217000742	putative reading head residues; other site
447217000743	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217000744	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217000745	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
447217000746	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217000747	active site
447217000748	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
447217000749	active site
447217000750	NTP binding site [chemical binding]; other site
447217000751	metal binding triad [ion binding]; metal-binding site
447217000752	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
447217000753	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
447217000754	putative nucleotide binding site [chemical binding]; other site
447217000755	uridine monophosphate binding site [chemical binding]; other site
447217000756	homohexameric interface [polypeptide binding]; other site
447217000757	ribosome recycling factor; Reviewed; Region: frr; PRK00083
447217000758	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
447217000759	hinge region; other site
447217000760	NAD synthetase; Provisional; Region: PRK13981
447217000761	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
447217000762	multimer interface [polypeptide binding]; other site
447217000763	active site
447217000764	catalytic triad [active]
447217000765	protein interface 1 [polypeptide binding]; other site
447217000766	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
447217000767	homodimer interface [polypeptide binding]; other site
447217000768	NAD binding pocket [chemical binding]; other site
447217000769	ATP binding pocket [chemical binding]; other site
447217000770	Mg binding site [ion binding]; other site
447217000771	active-site loop [active]
447217000772	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217000773	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217000774	metal binding site [ion binding]; metal-binding site
447217000775	active site
447217000776	I-site; other site
447217000777	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217000778	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000779	DNA binding residues [nucleotide binding]
447217000780	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
447217000781	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
447217000782	TPP-binding site [chemical binding]; other site
447217000783	dimer interface [polypeptide binding]; other site
447217000784	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
447217000785	PYR/PP interface [polypeptide binding]; other site
447217000786	dimer interface [polypeptide binding]; other site
447217000787	TPP binding site [chemical binding]; other site
447217000788	Ycf46; Provisional; Region: ycf46; CHL00195
447217000789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000790	ATP binding site [chemical binding]; other site
447217000791	Walker A motif; other site
447217000792	Walker B motif; other site
447217000793	arginine finger; other site
447217000794	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
447217000795	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
447217000796	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
447217000797	active site
447217000798	catalytic site [active]
447217000799	4-alpha-glucanotransferase; Provisional; Region: PRK14508
447217000800	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
447217000801	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
447217000802	active site
447217000803	HIGH motif; other site
447217000804	nucleotide binding site [chemical binding]; other site
447217000805	active site
447217000806	KMSKS motif; other site
447217000807	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
447217000808	active site
447217000809	dinuclear metal binding site [ion binding]; other site
447217000810	dimerization interface [polypeptide binding]; other site
447217000811	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
447217000812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000813	ATP binding site [chemical binding]; other site
447217000814	Mg2+ binding site [ion binding]; other site
447217000815	G-X-G motif; other site
447217000816	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000818	active site
447217000819	phosphorylation site [posttranslational modification]
447217000820	intermolecular recognition site; other site
447217000821	dimerization interface [polypeptide binding]; other site
447217000822	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000823	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000824	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000825	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000826	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000827	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000828	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
447217000829	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
447217000830	FAD binding pocket [chemical binding]; other site
447217000831	FAD binding motif [chemical binding]; other site
447217000832	phosphate binding motif [ion binding]; other site
447217000833	beta-alpha-beta structure motif; other site
447217000834	NAD binding pocket [chemical binding]; other site
447217000835	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
447217000836	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217000837	dimerization interface [polypeptide binding]; other site
447217000838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000839	dimer interface [polypeptide binding]; other site
447217000840	phosphorylation site [posttranslational modification]
447217000841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000842	ATP binding site [chemical binding]; other site
447217000843	Mg2+ binding site [ion binding]; other site
447217000844	G-X-G motif; other site
447217000845	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217000846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000847	active site
447217000848	phosphorylation site [posttranslational modification]
447217000849	intermolecular recognition site; other site
447217000850	dimerization interface [polypeptide binding]; other site
447217000851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000852	ATP binding site [chemical binding]; other site
447217000853	Walker B motif; other site
447217000854	arginine finger; other site
447217000855	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217000856	Protein of unknown function (DUF456); Region: DUF456; cl01069
447217000857	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
447217000858	Ligand binding site; other site
447217000859	metal-binding site
447217000860	Uncharacterized conserved protein [Function unknown]; Region: COG3342
447217000861	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
447217000862	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
447217000863	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217000864	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
447217000865	active site 1 [active]
447217000866	dimer interface [polypeptide binding]; other site
447217000867	hexamer interface [polypeptide binding]; other site
447217000868	active site 2 [active]
447217000869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217000870	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
447217000871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217000872	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
447217000873	dimerization interface [polypeptide binding]; other site
447217000874	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217000875	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
447217000876	dimer interface [polypeptide binding]; other site
447217000877	decamer (pentamer of dimers) interface [polypeptide binding]; other site
447217000878	catalytic triad [active]
447217000879	peroxidatic and resolving cysteines [active]
447217000880	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
447217000881	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
447217000882	Predicted ATPase [General function prediction only]; Region: COG3899
447217000883	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000884	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217000885	DNA binding residues [nucleotide binding]
447217000886	dimerization interface [polypeptide binding]; other site
447217000887	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217000888	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000889	DNA binding residues [nucleotide binding]
447217000890	dimerization interface [polypeptide binding]; other site
447217000891	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
447217000892	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
447217000893	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217000894	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
447217000895	Bacterial Ig-like domain; Region: Big_5; pfam13205
447217000896	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
447217000897	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217000898	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217000899	Zn binding site [ion binding]; other site
447217000900	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
447217000901	methionine sulfoxide reductase B; Provisional; Region: PRK00222
447217000902	SelR domain; Region: SelR; pfam01641
447217000903	Activator of aromatic catabolism; Region: XylR_N; pfam06505
447217000904	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
447217000905	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217000906	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000907	Walker B motif; other site
447217000908	arginine finger; other site
447217000909	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217000910	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
447217000911	eyelet of channel; other site
447217000912	trimer interface [polypeptide binding]; other site
447217000913	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
447217000914	reductive dehalogenase; Region: RDH; TIGR02486
447217000915	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
447217000916	4Fe-4S binding domain; Region: Fer4_6; pfam12837
447217000917	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
447217000918	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
447217000919	putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315
447217000920	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
447217000921	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
447217000922	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
447217000923	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217000924	Activator of aromatic catabolism; Region: XylR_N; pfam06505
447217000925	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
447217000926	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217000927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000928	Walker A motif; other site
447217000929	ATP binding site [chemical binding]; other site
447217000930	Walker B motif; other site
447217000931	arginine finger; other site
447217000932	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217000933	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
447217000934	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
447217000935	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217000936	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217000937	catalytic residues [active]
447217000938	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
447217000939	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000940	dimer interface [polypeptide binding]; other site
447217000941	putative CheW interface [polypeptide binding]; other site
447217000942	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
447217000943	UbiA prenyltransferase family; Region: UbiA; pfam01040
447217000944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000945	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217000946	dimerization interface [polypeptide binding]; other site
447217000947	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
447217000948	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
447217000949	intracellular protease, PfpI family; Region: PfpI; TIGR01382
447217000950	conserved cys residue [active]
447217000951	Predicted transcriptional regulators [Transcription]; Region: COG1695
447217000952	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
447217000953	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217000954	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
447217000955	catalytic site [active]
447217000956	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
447217000957	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000958	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217000959	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
447217000960	putative dimerization interface [polypeptide binding]; other site
447217000961	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
447217000962	CheB methylesterase; Region: CheB_methylest; pfam01339
447217000963	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217000964	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
447217000965	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217000966	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
447217000967	PAS domain; Region: PAS_10; pfam13596
447217000968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000970	dimer interface [polypeptide binding]; other site
447217000971	phosphorylation site [posttranslational modification]
447217000972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000973	ATP binding site [chemical binding]; other site
447217000974	Mg2+ binding site [ion binding]; other site
447217000975	G-X-G motif; other site
447217000976	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000978	active site
447217000979	phosphorylation site [posttranslational modification]
447217000980	intermolecular recognition site; other site
447217000981	dimerization interface [polypeptide binding]; other site
447217000982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000984	ATP binding site [chemical binding]; other site
447217000985	Mg2+ binding site [ion binding]; other site
447217000986	G-X-G motif; other site
447217000987	Fatty acid desaturase; Region: FA_desaturase; pfam00487
447217000988	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
447217000989	putative di-iron ligands [ion binding]; other site
447217000990	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
447217000991	Protein of unknown function (DUF330); Region: DUF330; cl01135
447217000992	mce related protein; Region: MCE; pfam02470
447217000993	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217000994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217000995	Walker A/P-loop; other site
447217000996	ATP binding site [chemical binding]; other site
447217000997	Q-loop/lid; other site
447217000998	ABC transporter signature motif; other site
447217000999	Walker B; other site
447217001000	D-loop; other site
447217001001	H-loop/switch region; other site
447217001002	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
447217001003	anti sigma factor interaction site; other site
447217001004	regulatory phosphorylation site [posttranslational modification]; other site
447217001005	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
447217001006	Permease; Region: Permease; pfam02405
447217001007	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
447217001008	Propionate catabolism activator; Region: PrpR_N; pfam06506
447217001009	PAS domain; Region: PAS_10; pfam13596
447217001010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001011	putative active site [active]
447217001012	heme pocket [chemical binding]; other site
447217001013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001014	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217001015	Walker A motif; other site
447217001016	ATP binding site [chemical binding]; other site
447217001017	Walker B motif; other site
447217001018	arginine finger; other site
447217001019	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217001020	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
447217001021	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
447217001022	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001023	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001024	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217001025	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
447217001026	substrate binding site [chemical binding]; other site
447217001027	oxyanion hole (OAH) forming residues; other site
447217001028	trimer interface [polypeptide binding]; other site
447217001029	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
447217001030	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217001031	dimer interface [polypeptide binding]; other site
447217001032	active site
447217001033	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217001034	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217001035	active site
447217001036	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
447217001037	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
447217001038	Moco binding site; other site
447217001039	metal coordination site [ion binding]; other site
447217001040	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
447217001041	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217001042	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
447217001043	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
447217001044	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
447217001045	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
447217001046	hinge; other site
447217001047	active site
447217001048	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
447217001049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217001050	peptide chain release factor 1; Validated; Region: prfA; PRK00591
447217001051	This domain is found in peptide chain release factors; Region: PCRF; smart00937
447217001052	RF-1 domain; Region: RF-1; pfam00472
447217001053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001054	PAS domain; Region: PAS_9; pfam13426
447217001055	putative active site [active]
447217001056	heme pocket [chemical binding]; other site
447217001057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001059	dimer interface [polypeptide binding]; other site
447217001060	phosphorylation site [posttranslational modification]
447217001061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001062	ATP binding site [chemical binding]; other site
447217001063	Mg2+ binding site [ion binding]; other site
447217001064	G-X-G motif; other site
447217001065	Predicted transcriptional regulators [Transcription]; Region: COG1510
447217001066	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
447217001067	UbiA prenyltransferase family; Region: UbiA; pfam01040
447217001068	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217001069	active site
447217001070	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
447217001071	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
447217001072	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
447217001073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217001074	FeS/SAM binding site; other site
447217001075	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
447217001076	Flavoprotein; Region: Flavoprotein; pfam02441
447217001077	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
447217001078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217001079	S-adenosylmethionine binding site [chemical binding]; other site
447217001080	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
447217001081	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217001082	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217001083	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
447217001084	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
447217001085	substrate binding pocket [chemical binding]; other site
447217001086	chain length determination region; other site
447217001087	substrate-Mg2+ binding site; other site
447217001088	catalytic residues [active]
447217001089	aspartate-rich region 1; other site
447217001090	active site lid residues [active]
447217001091	aspartate-rich region 2; other site
447217001092	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
447217001093	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
447217001094	dimerization interface 3.5A [polypeptide binding]; other site
447217001095	active site
447217001096	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
447217001097	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
447217001098	Hemerythrin; Region: Hemerythrin; cd12107
447217001099	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
447217001100	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
447217001101	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
447217001102	Clp amino terminal domain; Region: Clp_N; pfam02861
447217001103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001104	Walker A motif; other site
447217001105	ATP binding site [chemical binding]; other site
447217001106	Walker B motif; other site
447217001107	arginine finger; other site
447217001108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001109	Walker A motif; other site
447217001110	ATP binding site [chemical binding]; other site
447217001111	Walker B motif; other site
447217001112	arginine finger; other site
447217001113	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
447217001114	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217001115	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217001116	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217001117	protein binding site [polypeptide binding]; other site
447217001118	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217001119	protein binding site [polypeptide binding]; other site
447217001120	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
447217001121	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
447217001122	malonyl-CoA binding site [chemical binding]; other site
447217001123	dimer interface [polypeptide binding]; other site
447217001124	active site
447217001125	product binding site; other site
447217001126	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
447217001127	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
447217001128	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217001129	acyl-activating enzyme (AAE) consensus motif; other site
447217001130	AMP binding site [chemical binding]; other site
447217001131	active site
447217001132	CoA binding site [chemical binding]; other site
447217001133	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
447217001134	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
447217001135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
447217001136	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
447217001137	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
447217001138	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
447217001139	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
447217001140	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
447217001141	active site
447217001142	Zn binding site [ion binding]; other site
447217001143	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
447217001144	FAD binding pocket [chemical binding]; other site
447217001145	FAD binding motif [chemical binding]; other site
447217001146	phosphate binding motif [ion binding]; other site
447217001147	beta-alpha-beta structure motif; other site
447217001148	NAD(p) ribose binding residues [chemical binding]; other site
447217001149	NAD binding pocket [chemical binding]; other site
447217001150	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
447217001151	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
447217001152	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
447217001153	ribonuclease Z; Region: RNase_Z; TIGR02651
447217001154	Pirin-related protein [General function prediction only]; Region: COG1741
447217001155	Pirin; Region: Pirin; pfam02678
447217001156	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
447217001157	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
447217001158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001159	Walker A/P-loop; other site
447217001160	ATP binding site [chemical binding]; other site
447217001161	Q-loop/lid; other site
447217001162	ABC transporter signature motif; other site
447217001163	Walker B; other site
447217001164	D-loop; other site
447217001165	H-loop/switch region; other site
447217001166	ParB-like nuclease domain; Region: ParB; smart00470
447217001167	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
447217001168	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217001169	dimer interface [polypeptide binding]; other site
447217001170	active site
447217001171	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
447217001172	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217001173	substrate binding site [chemical binding]; other site
447217001174	oxyanion hole (OAH) forming residues; other site
447217001175	trimer interface [polypeptide binding]; other site
447217001176	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
447217001177	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001178	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001179	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217001180	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217001181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001183	dimer interface [polypeptide binding]; other site
447217001184	phosphorylation site [posttranslational modification]
447217001185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001186	ATP binding site [chemical binding]; other site
447217001187	G-X-G motif; other site
447217001188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217001189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001190	active site
447217001191	phosphorylation site [posttranslational modification]
447217001192	intermolecular recognition site; other site
447217001193	dimerization interface [polypeptide binding]; other site
447217001194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217001195	DNA binding site [nucleotide binding]
447217001196	selenocysteine synthase; Provisional; Region: PRK04311
447217001197	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
447217001198	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217001199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217001200	catalytic residue [active]
447217001201	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
447217001202	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
447217001203	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217001204	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
447217001205	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217001206	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
447217001207	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
447217001209	active site
447217001210	phosphorylation site [posttranslational modification]
447217001211	intermolecular recognition site; other site
447217001212	dimerization interface [polypeptide binding]; other site
447217001213	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001215	active site
447217001216	phosphorylation site [posttranslational modification]
447217001217	intermolecular recognition site; other site
447217001218	dimerization interface [polypeptide binding]; other site
447217001219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001220	Walker A motif; other site
447217001221	ATP binding site [chemical binding]; other site
447217001222	Walker B motif; other site
447217001223	arginine finger; other site
447217001224	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217001225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001226	PAS domain; Region: PAS_9; pfam13426
447217001227	putative active site [active]
447217001228	heme pocket [chemical binding]; other site
447217001229	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217001230	GAF domain; Region: GAF; pfam01590
447217001231	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217001232	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217001233	GAF domain; Region: GAF_3; pfam13492
447217001234	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217001235	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217001236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001238	dimer interface [polypeptide binding]; other site
447217001239	phosphorylation site [posttranslational modification]
447217001240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001241	ATP binding site [chemical binding]; other site
447217001242	G-X-G motif; other site
447217001243	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
447217001244	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
447217001245	G1 box; other site
447217001246	putative GEF interaction site [polypeptide binding]; other site
447217001247	GTP/Mg2+ binding site [chemical binding]; other site
447217001248	Switch I region; other site
447217001249	G2 box; other site
447217001250	G3 box; other site
447217001251	Switch II region; other site
447217001252	G4 box; other site
447217001253	G5 box; other site
447217001254	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
447217001255	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
447217001256	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
447217001257	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
447217001258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217001259	active site
447217001260	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
447217001261	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
447217001262	dimerization interface [polypeptide binding]; other site
447217001263	domain crossover interface; other site
447217001264	redox-dependent activation switch; other site
447217001265	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
447217001266	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217001267	putative NAD(P) binding site [chemical binding]; other site
447217001268	active site
447217001269	putative substrate binding site [chemical binding]; other site
447217001270	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217001271	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217001272	putative acyl-acceptor binding pocket; other site
447217001273	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
447217001274	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001275	binding surface
447217001276	TPR motif; other site
447217001277	TPR repeat; Region: TPR_11; pfam13414
447217001278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001279	TPR motif; other site
447217001280	binding surface
447217001281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001282	TPR motif; other site
447217001283	binding surface
447217001284	TPR repeat; Region: TPR_11; pfam13414
447217001285	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
447217001286	MarR family; Region: MarR_2; cl17246
447217001287	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
447217001288	GAF domain; Region: GAF; cl17456
447217001289	GAF domain; Region: GAF; pfam01590
447217001290	GAF domain; Region: GAF_2; pfam13185
447217001291	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217001292	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217001293	phosphopeptide binding site; other site
447217001294	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217001295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217001296	metal binding site [ion binding]; metal-binding site
447217001297	active site
447217001298	I-site; other site
447217001299	Protein of unknown function DUF72; Region: DUF72; pfam01904
447217001300	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217001301	putative catalytic site [active]
447217001302	putative metal binding site [ion binding]; other site
447217001303	putative phosphate binding site [ion binding]; other site
447217001304	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
447217001305	active site
447217001306	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
447217001307	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217001308	active site
447217001309	RHS protein; Region: RHS; pfam03527
447217001310	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217001311	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001312	Walker A/P-loop; other site
447217001313	ATP binding site [chemical binding]; other site
447217001314	Q-loop/lid; other site
447217001315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001316	ABC transporter signature motif; other site
447217001317	Walker B; other site
447217001318	D-loop; other site
447217001319	H-loop/switch region; other site
447217001320	exonuclease subunit SbcD; Provisional; Region: PRK10966
447217001321	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
447217001322	active site
447217001323	metal binding site [ion binding]; metal-binding site
447217001324	DNA binding site [nucleotide binding]
447217001325	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
447217001326	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217001327	active site residue [active]
447217001328	Chromate transporter; Region: Chromate_transp; pfam02417
447217001329	Chromate transporter; Region: Chromate_transp; pfam02417
447217001330	NosL; Region: NosL; cl01769
447217001331	FtsX-like permease family; Region: FtsX; pfam02687
447217001332	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217001333	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217001334	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217001335	Walker A/P-loop; other site
447217001336	ATP binding site [chemical binding]; other site
447217001337	Q-loop/lid; other site
447217001338	ABC transporter signature motif; other site
447217001339	Walker B; other site
447217001340	D-loop; other site
447217001341	H-loop/switch region; other site
447217001342	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
447217001343	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
447217001344	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217001345	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
447217001346	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
447217001347	active site
447217001348	homotetramer interface [polypeptide binding]; other site
447217001349	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
447217001350	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
447217001351	dinuclear metal binding motif [ion binding]; other site
447217001352	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217001353	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217001354	active site
447217001355	catalytic tetrad [active]
447217001356	Methyltransferase domain; Region: Methyltransf_23; pfam13489
447217001357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217001358	S-adenosylmethionine binding site [chemical binding]; other site
447217001359	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
447217001360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001361	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
447217001362	Walker A/P-loop; other site
447217001363	ATP binding site [chemical binding]; other site
447217001364	Q-loop/lid; other site
447217001365	ABC transporter signature motif; other site
447217001366	Walker B; other site
447217001367	D-loop; other site
447217001368	H-loop/switch region; other site
447217001369	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001370	dimerization interface [polypeptide binding]; other site
447217001371	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
447217001372	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
447217001373	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
447217001374	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217001375	substrate binding pocket [chemical binding]; other site
447217001376	membrane-bound complex binding site; other site
447217001377	hinge residues; other site
447217001378	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217001379	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
447217001380	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
447217001381	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217001382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217001383	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
447217001384	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
447217001385	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217001386	carboxyltransferase (CT) interaction site; other site
447217001387	biotinylation site [posttranslational modification]; other site
447217001388	RNA polymerase sigma factor; Provisional; Region: PRK11922
447217001389	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217001390	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
447217001391	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
447217001392	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
447217001393	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
447217001394	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217001395	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
447217001396	Soluble P-type ATPase [General function prediction only]; Region: COG4087
447217001397	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
447217001398	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
447217001399	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
447217001400	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217001401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217001402	homodimer interface [polypeptide binding]; other site
447217001403	catalytic residue [active]
447217001404	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217001405	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
447217001406	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
447217001407	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
447217001408	dimerization interface [polypeptide binding]; other site
447217001409	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
447217001410	ATP binding site [chemical binding]; other site
447217001411	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
447217001412	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
447217001413	HupF/HypC family; Region: HupF_HypC; pfam01455
447217001414	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
447217001415	Acylphosphatase; Region: Acylphosphatase; pfam00708
447217001416	HypF finger; Region: zf-HYPF; pfam07503
447217001417	HypF finger; Region: zf-HYPF; pfam07503
447217001418	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
447217001419	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
447217001420	nickel binding site [ion binding]; other site
447217001421	hydrogenase 2 large subunit; Provisional; Region: PRK10467
447217001422	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
447217001423	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
447217001424	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
447217001425	hydrogenase 2 small subunit; Provisional; Region: PRK10468
447217001426	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
447217001427	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
447217001428	MarR family; Region: MarR_2; pfam12802
447217001429	Nudix hydrolase homolog; Region: PLN02791
447217001430	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
447217001431	N-terminal plug; other site
447217001432	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
447217001433	ligand-binding site [chemical binding]; other site
447217001434	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217001435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001436	TPR repeat; Region: TPR_11; pfam13414
447217001437	TPR motif; other site
447217001438	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
447217001439	MgtC family; Region: MgtC; pfam02308
447217001440	Predicted membrane protein [Function unknown]; Region: COG2119
447217001441	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
447217001442	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
447217001443	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
447217001444	YwiC-like protein; Region: YwiC; pfam14256
447217001445	Staphylococcal nuclease homologues; Region: SNc; smart00318
447217001446	Hemerythrin; Region: Hemerythrin; cd12107
447217001447	Fe binding site [ion binding]; other site
447217001448	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
447217001449	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
447217001450	Walker A/P-loop; other site
447217001451	ATP binding site [chemical binding]; other site
447217001452	Q-loop/lid; other site
447217001453	ABC transporter signature motif; other site
447217001454	Walker B; other site
447217001455	D-loop; other site
447217001456	H-loop/switch region; other site
447217001457	cobalt transport protein CbiM; Provisional; Region: PRK07331
447217001458	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
447217001459	nickel responsive regulator; Provisional; Region: PRK04460
447217001460	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
447217001461	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
447217001462	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
447217001463	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217001464	substrate binding site [chemical binding]; other site
447217001465	ATP binding site [chemical binding]; other site
447217001466	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217001467	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217001468	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001470	dimer interface [polypeptide binding]; other site
447217001471	phosphorylation site [posttranslational modification]
447217001472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001473	ATP binding site [chemical binding]; other site
447217001474	G-X-G motif; other site
447217001475	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001477	active site
447217001478	phosphorylation site [posttranslational modification]
447217001479	intermolecular recognition site; other site
447217001480	dimerization interface [polypeptide binding]; other site
447217001481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001482	Walker A motif; other site
447217001483	ATP binding site [chemical binding]; other site
447217001484	Walker B motif; other site
447217001485	arginine finger; other site
447217001486	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217001487	Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920
447217001488	putative active site [active]
447217001489	redox center [active]
447217001490	Thioredoxin; Region: Thioredoxin_4; cl17273
447217001491	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217001492	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217001493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001494	putative active site [active]
447217001495	heme pocket [chemical binding]; other site
447217001496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001497	dimer interface [polypeptide binding]; other site
447217001498	phosphorylation site [posttranslational modification]
447217001499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001500	ATP binding site [chemical binding]; other site
447217001501	Mg2+ binding site [ion binding]; other site
447217001502	G-X-G motif; other site
447217001503	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217001504	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217001505	dimerization interface [polypeptide binding]; other site
447217001506	active site
447217001507	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
447217001508	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
447217001509	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217001510	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
447217001511	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
447217001512	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
447217001513	Protein export membrane protein; Region: SecD_SecF; cl14618
447217001514	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217001515	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217001516	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217001517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217001518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217001519	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
447217001520	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
447217001521	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217001522	Ca binding site [ion binding]; other site
447217001523	active site
447217001524	catalytic site [active]
447217001525	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
447217001526	Calicivirus coat protein C-terminal; Region: Calici_coat_C; pfam08435
447217001527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
447217001528	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
447217001529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217001530	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001531	dimerization interface [polypeptide binding]; other site
447217001532	aspartate racemase; Region: asp_race; TIGR00035
447217001533	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
447217001534	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217001535	putative dimer interface [polypeptide binding]; other site
447217001536	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217001537	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217001538	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
447217001539	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217001540	aspartate aminotransferase; Provisional; Region: PRK06836
447217001541	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217001542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217001543	homodimer interface [polypeptide binding]; other site
447217001544	catalytic residue [active]
447217001545	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217001546	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217001547	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
447217001548	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001550	dimer interface [polypeptide binding]; other site
447217001551	phosphorylation site [posttranslational modification]
447217001552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001553	ATP binding site [chemical binding]; other site
447217001554	Mg2+ binding site [ion binding]; other site
447217001555	G-X-G motif; other site
447217001556	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
447217001557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001558	Walker A/P-loop; other site
447217001559	ATP binding site [chemical binding]; other site
447217001560	Q-loop/lid; other site
447217001561	ABC transporter signature motif; other site
447217001562	Walker B; other site
447217001563	D-loop; other site
447217001564	H-loop/switch region; other site
447217001565	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
447217001566	putative hydrolase; Provisional; Region: PRK11460
447217001567	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217001568	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217001569	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
447217001570	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
447217001571	DsrE/DsrF-like family; Region: DrsE; pfam02635
447217001572	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217001573	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217001574	active site
447217001575	catalytic tetrad [active]
447217001576	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
447217001577	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217001578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217001579	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217001580	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
447217001581	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217001582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217001583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001584	dimerization interface [polypeptide binding]; other site
447217001585	short chain dehydrogenase; Provisional; Region: PRK08303
447217001586	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001587	NAD(P) binding site [chemical binding]; other site
447217001588	active site
447217001589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217001590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217001591	putative substrate translocation pore; other site
447217001592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217001593	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
447217001594	Right handed beta helix region; Region: Beta_helix; pfam13229
447217001595	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
447217001596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001597	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217001598	NAD(P) binding site [chemical binding]; other site
447217001599	active site
447217001600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217001601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217001602	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
447217001603	putative effector binding pocket; other site
447217001604	putative dimerization interface [polypeptide binding]; other site
447217001605	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
447217001606	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217001607	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217001608	DNA binding residues [nucleotide binding]
447217001609	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
447217001610	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
447217001611	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
447217001612	Fic family protein [Function unknown]; Region: COG3177
447217001613	Fic/DOC family; Region: Fic; pfam02661
447217001614	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217001615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
447217001616	ATP binding site [chemical binding]; other site
447217001617	putative Mg++ binding site [ion binding]; other site
447217001618	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
447217001619	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
447217001620	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
447217001621	metal binding site [ion binding]; metal-binding site
447217001622	putative dimer interface [polypeptide binding]; other site
447217001623	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
447217001624	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217001625	active site
447217001626	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
447217001627	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
447217001628	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
447217001629	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001631	active site
447217001632	phosphorylation site [posttranslational modification]
447217001633	intermolecular recognition site; other site
447217001634	dimerization interface [polypeptide binding]; other site
447217001635	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217001636	GAF domain; Region: GAF_3; pfam13492
447217001637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217001638	metal binding site [ion binding]; metal-binding site
447217001639	active site
447217001640	I-site; other site
447217001641	Tellurium resistance protein; Region: Tellurium_res; pfam10138
447217001642	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001644	active site
447217001645	phosphorylation site [posttranslational modification]
447217001646	intermolecular recognition site; other site
447217001647	dimerization interface [polypeptide binding]; other site
447217001648	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217001649	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
447217001650	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217001651	KMSKS motif; other site
447217001652	Hemerythrin; Region: Hemerythrin; cd12107
447217001653	Fe binding site [ion binding]; other site
447217001654	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217001655	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217001656	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217001657	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217001658	dimerization interface [polypeptide binding]; other site
447217001659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001660	ATP binding site [chemical binding]; other site
447217001661	Mg2+ binding site [ion binding]; other site
447217001662	G-X-G motif; other site
447217001663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
447217001664	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
447217001665	WYL domain; Region: WYL; pfam13280
447217001666	WYL domain; Region: WYL; pfam13280
447217001667	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001669	active site
447217001670	phosphorylation site [posttranslational modification]
447217001671	intermolecular recognition site; other site
447217001672	dimerization interface [polypeptide binding]; other site
447217001673	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
447217001674	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
447217001675	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
447217001676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217001677	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
447217001678	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
447217001679	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
447217001680	heterotetramer interface [polypeptide binding]; other site
447217001681	active site pocket [active]
447217001682	cleavage site
447217001683	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
447217001684	homohexameric interface [polypeptide binding]; other site
447217001685	feedback inhibition sensing region; other site
447217001686	nucleotide binding site [chemical binding]; other site
447217001687	N-acetyl-L-glutamate binding site [chemical binding]; other site
447217001688	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
447217001689	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
447217001690	Bacterial Ig-like domain; Region: Big_5; pfam13205
447217001691	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217001692	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
447217001693	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217001694	DsbD alpha interface [polypeptide binding]; other site
447217001695	catalytic residues [active]
447217001696	cysteine desulfurase; Provisional; Region: PRK14012
447217001697	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
447217001698	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217001699	catalytic residue [active]
447217001700	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
447217001701	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
447217001702	trimerization site [polypeptide binding]; other site
447217001703	active site
447217001704	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
447217001705	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217001706	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
447217001707	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
447217001708	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
447217001709	nucleotide binding site [chemical binding]; other site
447217001710	putative NEF/HSP70 interaction site [polypeptide binding]; other site
447217001711	SBD interface [polypeptide binding]; other site
447217001712	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
447217001713	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217001714	catalytic loop [active]
447217001715	iron binding site [ion binding]; other site
447217001716	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
447217001717	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217001718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001719	active site
447217001720	phosphorylation site [posttranslational modification]
447217001721	intermolecular recognition site; other site
447217001722	dimerization interface [polypeptide binding]; other site
447217001723	CheB methylesterase; Region: CheB_methylest; pfam01339
447217001724	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
447217001725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217001726	S-adenosylmethionine binding site [chemical binding]; other site
447217001727	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217001728	putative CheA interaction surface; other site
447217001729	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217001730	putative binding surface; other site
447217001731	active site
447217001732	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217001733	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217001734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001735	ATP binding site [chemical binding]; other site
447217001736	Mg2+ binding site [ion binding]; other site
447217001737	G-X-G motif; other site
447217001738	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217001739	CheD chemotactic sensory transduction; Region: CheD; cl00810
447217001740	GAF domain; Region: GAF_3; pfam13492
447217001741	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001743	active site
447217001744	phosphorylation site [posttranslational modification]
447217001745	intermolecular recognition site; other site
447217001746	dimerization interface [polypeptide binding]; other site
447217001747	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217001748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001749	active site
447217001750	phosphorylation site [posttranslational modification]
447217001751	intermolecular recognition site; other site
447217001752	CheW-like domain; Region: CheW; pfam01584
447217001753	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217001754	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217001755	dimer interface [polypeptide binding]; other site
447217001756	putative CheW interface [polypeptide binding]; other site
447217001757	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217001758	putative binding surface; other site
447217001759	active site
447217001760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001761	ATP binding site [chemical binding]; other site
447217001762	Mg2+ binding site [ion binding]; other site
447217001763	G-X-G motif; other site
447217001764	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217001765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001766	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001767	active site
447217001768	phosphorylation site [posttranslational modification]
447217001769	intermolecular recognition site; other site
447217001770	dimerization interface [polypeptide binding]; other site
447217001771	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217001772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001773	active site
447217001774	phosphorylation site [posttranslational modification]
447217001775	intermolecular recognition site; other site
447217001776	dimerization interface [polypeptide binding]; other site
447217001777	CheB methylesterase; Region: CheB_methylest; pfam01339
447217001778	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217001779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217001780	S-adenosylmethionine binding site [chemical binding]; other site
447217001781	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001783	active site
447217001784	phosphorylation site [posttranslational modification]
447217001785	intermolecular recognition site; other site
447217001786	dimerization interface [polypeptide binding]; other site
447217001787	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
447217001788	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
447217001789	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
447217001790	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
447217001791	purine nucleoside phosphorylase; Provisional; Region: PRK08202
447217001792	PilZ domain; Region: PilZ; pfam07238
447217001793	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
447217001794	active site
447217001795	catalytic motif [active]
447217001796	Zn binding site [ion binding]; other site
447217001797	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
447217001798	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
447217001799	active site
447217001800	Riboflavin kinase; Region: Flavokinase; pfam01687
447217001801	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
447217001802	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217001803	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
447217001804	Walker A motif; other site
447217001805	ATP binding site [chemical binding]; other site
447217001806	Walker B motif; other site
447217001807	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
447217001808	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
447217001809	Walker A motif; other site
447217001810	ATP binding site [chemical binding]; other site
447217001811	Walker B motif; other site
447217001812	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
447217001813	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217001814	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217001815	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217001816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001817	putative active site [active]
447217001818	heme pocket [chemical binding]; other site
447217001819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001820	dimer interface [polypeptide binding]; other site
447217001821	phosphorylation site [posttranslational modification]
447217001822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001823	ATP binding site [chemical binding]; other site
447217001824	Mg2+ binding site [ion binding]; other site
447217001825	G-X-G motif; other site
447217001826	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001828	active site
447217001829	phosphorylation site [posttranslational modification]
447217001830	intermolecular recognition site; other site
447217001831	dimerization interface [polypeptide binding]; other site
447217001832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001833	Walker A motif; other site
447217001834	ATP binding site [chemical binding]; other site
447217001835	Walker B motif; other site
447217001836	arginine finger; other site
447217001837	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
447217001838	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217001839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001840	TPR motif; other site
447217001841	binding surface
447217001842	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
447217001843	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217001844	Walker A/P-loop; other site
447217001845	ATP binding site [chemical binding]; other site
447217001846	Q-loop/lid; other site
447217001847	ABC transporter signature motif; other site
447217001848	Walker B; other site
447217001849	D-loop; other site
447217001850	H-loop/switch region; other site
447217001851	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
447217001852	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
447217001853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001854	dimer interface [polypeptide binding]; other site
447217001855	phosphorylation site [posttranslational modification]
447217001856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001857	ATP binding site [chemical binding]; other site
447217001858	Mg2+ binding site [ion binding]; other site
447217001859	G-X-G motif; other site
447217001860	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001862	active site
447217001863	phosphorylation site [posttranslational modification]
447217001864	intermolecular recognition site; other site
447217001865	dimerization interface [polypeptide binding]; other site
447217001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001867	Walker A motif; other site
447217001868	ATP binding site [chemical binding]; other site
447217001869	Walker B motif; other site
447217001870	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217001871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217001872	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217001873	non-specific DNA binding site [nucleotide binding]; other site
447217001874	salt bridge; other site
447217001875	sequence-specific DNA binding site [nucleotide binding]; other site
447217001876	Competence protein A; Region: Competence_A; pfam11104
447217001877	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217001878	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
447217001879	Pilus assembly protein, PilO; Region: PilO; pfam04350
447217001880	Pilus assembly protein, PilP; Region: PilP; pfam04351
447217001881	AMIN domain; Region: AMIN; pfam11741
447217001882	AMIN domain; Region: AMIN; pfam11741
447217001883	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
447217001884	Secretin and TonB N terminus short domain; Region: STN; pfam07660
447217001885	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217001886	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217001887	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
447217001888	elongation factor P; Validated; Region: PRK00529
447217001889	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
447217001890	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
447217001891	RNA binding site [nucleotide binding]; other site
447217001892	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
447217001893	RNA binding site [nucleotide binding]; other site
447217001894	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
447217001895	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217001896	carboxyltransferase (CT) interaction site; other site
447217001897	biotinylation site [posttranslational modification]; other site
447217001898	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
447217001899	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217001900	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217001901	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
447217001902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001903	binding surface
447217001904	TPR motif; other site
447217001905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001906	binding surface
447217001907	TPR motif; other site
447217001908	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217001909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001910	binding surface
447217001911	TPR motif; other site
447217001912	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
447217001913	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217001914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
447217001915	Family of unknown function (DUF490); Region: DUF490; pfam04357
447217001916	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
447217001917	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217001918	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217001919	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
447217001920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217001921	exopolyphosphatase; Region: exo_poly_only; TIGR03706
447217001922	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
447217001923	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
447217001924	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217001925	TolB amino-terminal domain; Region: TolB_N; pfam04052
447217001926	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001927	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001928	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001929	TonB C terminal; Region: TonB_2; pfam13103
447217001930	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
447217001931	TolR protein; Region: tolR; TIGR02801
447217001932	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217001933	glutamate racemase; Provisional; Region: PRK00865
447217001934	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
447217001935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217001936	Walker A/P-loop; other site
447217001937	ATP binding site [chemical binding]; other site
447217001938	Q-loop/lid; other site
447217001939	ABC transporter signature motif; other site
447217001940	Walker B; other site
447217001941	D-loop; other site
447217001942	H-loop/switch region; other site
447217001943	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
447217001944	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217001945	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217001946	C-terminal peptidase (prc); Region: prc; TIGR00225
447217001947	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217001948	protein binding site [polypeptide binding]; other site
447217001949	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
447217001950	Catalytic dyad [active]
447217001951	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
447217001952	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217001953	DXD motif; other site
447217001954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217001955	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
447217001956	Coenzyme A binding pocket [chemical binding]; other site
447217001957	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
447217001958	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217001959	motif II; other site
447217001960	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
447217001961	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
447217001962	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
447217001963	P loop; other site
447217001964	GTP binding site [chemical binding]; other site
447217001965	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
447217001966	AAA domain; Region: AAA_23; pfam13476
447217001967	Walker A/P-loop; other site
447217001968	ATP binding site [chemical binding]; other site
447217001969	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
447217001970	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
447217001971	Q-loop/lid; other site
447217001972	ABC transporter signature motif; other site
447217001973	Walker B; other site
447217001974	D-loop; other site
447217001975	H-loop/switch region; other site
447217001976	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217001977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217001978	dimerization interface [polypeptide binding]; other site
447217001979	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217001980	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217001981	dimer interface [polypeptide binding]; other site
447217001982	putative CheW interface [polypeptide binding]; other site
447217001983	Competence protein A; Region: Competence_A; pfam11104
447217001984	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
447217001985	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
447217001986	type II secretion system protein J; Region: gspJ; TIGR01711
447217001987	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
447217001988	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
447217001989	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
447217001990	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
447217001991	type II secretion system protein F; Region: GspF; TIGR02120
447217001992	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217001993	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217001994	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217001995	type II secretion system protein E; Region: type_II_gspE; TIGR02533
447217001996	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
447217001997	Walker A motif; other site
447217001998	ATP binding site [chemical binding]; other site
447217001999	Walker B motif; other site
447217002000	type II secretion system protein D; Region: type_II_gspD; TIGR02517
447217002001	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217002002	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217002003	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217002004	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217002005	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
447217002006	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217002007	protein binding site [polypeptide binding]; other site
447217002008	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002010	active site
447217002011	phosphorylation site [posttranslational modification]
447217002012	intermolecular recognition site; other site
447217002013	dimerization interface [polypeptide binding]; other site
447217002014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002015	Walker A motif; other site
447217002016	ATP binding site [chemical binding]; other site
447217002017	Walker B motif; other site
447217002018	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217002019	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
447217002020	transcription termination factor Rho; Provisional; Region: rho; PRK09376
447217002021	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
447217002022	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
447217002023	RNA binding site [nucleotide binding]; other site
447217002024	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
447217002025	multimer interface [polypeptide binding]; other site
447217002026	Walker A motif; other site
447217002027	ATP binding site [chemical binding]; other site
447217002028	Walker B motif; other site
447217002029	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
447217002030	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
447217002031	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
447217002032	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
447217002033	nucleotide binding pocket [chemical binding]; other site
447217002034	K-X-D-G motif; other site
447217002035	catalytic site [active]
447217002036	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
447217002037	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
447217002038	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
447217002039	Dimer interface [polypeptide binding]; other site
447217002040	BRCT sequence motif; other site
447217002041	acylphosphatase; Provisional; Region: PRK14441
447217002042	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
447217002043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217002044	FeS/SAM binding site; other site
447217002045	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
447217002046	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
447217002047	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
447217002048	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217002049	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
447217002050	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
447217002051	Transcriptional regulator; Region: Rrf2; cl17282
447217002052	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217002053	IHF dimer interface [polypeptide binding]; other site
447217002054	IHF - DNA interface [nucleotide binding]; other site
447217002055	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
447217002056	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
447217002057	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
447217002058	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
447217002059	FliP family; Region: FliP; cl00593
447217002060	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
447217002061	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
447217002062	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
447217002063	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
447217002064	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
447217002065	dinuclear metal binding motif [ion binding]; other site
447217002066	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
447217002067	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217002068	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217002069	DNA binding residues [nucleotide binding]
447217002070	dimerization interface [polypeptide binding]; other site
447217002071	histidinol dehydrogenase; Region: hisD; TIGR00069
447217002072	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
447217002073	NAD binding site [chemical binding]; other site
447217002074	dimerization interface [polypeptide binding]; other site
447217002075	product binding site; other site
447217002076	substrate binding site [chemical binding]; other site
447217002077	zinc binding site [ion binding]; other site
447217002078	catalytic residues [active]
447217002079	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
447217002080	putative active site pocket [active]
447217002081	4-fold oligomerization interface [polypeptide binding]; other site
447217002082	metal binding residues [ion binding]; metal-binding site
447217002083	3-fold/trimer interface [polypeptide binding]; other site
447217002084	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
447217002085	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
447217002086	putative active site [active]
447217002087	oxyanion strand; other site
447217002088	catalytic triad [active]
447217002089	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
447217002090	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
447217002091	catalytic residues [active]
447217002092	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
447217002093	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
447217002094	substrate binding site [chemical binding]; other site
447217002095	glutamase interaction surface [polypeptide binding]; other site
447217002096	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
447217002097	metal binding site [ion binding]; metal-binding site
447217002098	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
447217002099	Yqey-like protein; Region: YqeY; pfam09424
447217002100	DNA primase, catalytic core; Region: dnaG; TIGR01391
447217002101	CHC2 zinc finger; Region: zf-CHC2; pfam01807
447217002102	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
447217002103	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
447217002104	active site
447217002105	metal binding site [ion binding]; metal-binding site
447217002106	interdomain interaction site; other site
447217002107	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
447217002108	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
447217002109	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217002110	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
447217002111	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002112	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
447217002113	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217002114	DNA binding residues [nucleotide binding]
447217002115	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
447217002116	Putative zinc ribbon domain; Region: DUF164; pfam02591
447217002117	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
447217002118	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217002119	active site
447217002120	Predicted membrane protein [Function unknown]; Region: COG1584
447217002121	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
447217002122	active site
447217002123	catalytic residues [active]
447217002124	metal binding site [ion binding]; metal-binding site
447217002125	primosome assembly protein PriA; Validated; Region: PRK05580
447217002126	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002127	ATP binding site [chemical binding]; other site
447217002128	putative Mg++ binding site [ion binding]; other site
447217002129	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
447217002130	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217002131	recombination factor protein RarA; Reviewed; Region: PRK13342
447217002132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002133	Walker A motif; other site
447217002134	ATP binding site [chemical binding]; other site
447217002135	Walker B motif; other site
447217002136	arginine finger; other site
447217002137	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
447217002138	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
447217002139	ATP-NAD kinase; Region: NAD_kinase; pfam01513
447217002140	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
447217002141	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
447217002142	Walker A/P-loop; other site
447217002143	ATP binding site [chemical binding]; other site
447217002144	Q-loop/lid; other site
447217002145	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
447217002146	ABC transporter signature motif; other site
447217002147	Walker B; other site
447217002148	D-loop; other site
447217002149	H-loop/switch region; other site
447217002150	Protein phosphatase 2C; Region: PP2C; pfam00481
447217002151	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
447217002152	active site
447217002153	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217002154	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217002155	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
447217002156	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
447217002157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
447217002158	nucleotide binding region [chemical binding]; other site
447217002159	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
447217002160	SEC-C motif; Region: SEC-C; pfam02810
447217002161	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
447217002162	AsnC family; Region: AsnC_trans_reg; pfam01037
447217002163	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217002164	active site
447217002165	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
447217002166	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
447217002167	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
447217002168	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
447217002169	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
447217002170	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
447217002171	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
447217002172	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
447217002173	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
447217002174	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
447217002175	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187
447217002176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
447217002177	Integrase core domain; Region: rve; pfam00665
447217002178	transposase/IS protein; Provisional; Region: PRK09183
447217002179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002180	Walker A motif; other site
447217002181	ATP binding site [chemical binding]; other site
447217002182	Walker B motif; other site
447217002183	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
447217002184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002185	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
447217002186	DNA binding residues [nucleotide binding]
447217002187	SnoaL-like domain; Region: SnoaL_2; pfam12680
447217002188	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002189	active site
447217002190	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
447217002191	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
447217002192	FAD binding pocket [chemical binding]; other site
447217002193	conserved FAD binding motif [chemical binding]; other site
447217002194	phosphate binding motif [ion binding]; other site
447217002195	beta-alpha-beta structure motif; other site
447217002196	NAD binding pocket [chemical binding]; other site
447217002197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217002198	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
447217002199	active site
447217002200	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
447217002201	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217002202	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217002203	active site
447217002204	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217002205	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
447217002206	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217002207	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217002208	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
447217002209	MarR family; Region: MarR; pfam01047
447217002210	GAF domain; Region: GAF_2; pfam13185
447217002211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002212	dimer interface [polypeptide binding]; other site
447217002213	phosphorylation site [posttranslational modification]
447217002214	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217002215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002216	ATP binding site [chemical binding]; other site
447217002217	Mg2+ binding site [ion binding]; other site
447217002218	G-X-G motif; other site
447217002219	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
447217002220	substrate binding site [chemical binding]; other site
447217002221	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
447217002222	putative deacylase active site [active]
447217002223	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
447217002224	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
447217002225	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
447217002226	Predicted permeases [General function prediction only]; Region: RarD; COG2962
447217002227	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217002228	Ligand Binding Site [chemical binding]; other site
447217002229	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
447217002230	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
447217002231	putative active site [active]
447217002232	putative FMN binding site [chemical binding]; other site
447217002233	putative substrate binding site [chemical binding]; other site
447217002234	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217002235	Ferritin-like domain; Region: Ferritin; pfam00210
447217002236	binuclear metal center [ion binding]; other site
447217002237	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217002238	Cysteine-rich domain; Region: CCG; pfam02754
447217002239	Cysteine-rich domain; Region: CCG; pfam02754
447217002240	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
447217002241	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
447217002242	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
447217002243	active site
447217002244	catalytic site [active]
447217002245	substrate binding site [chemical binding]; other site
447217002246	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
447217002247	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217002248	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217002249	ligand binding site [chemical binding]; other site
447217002250	flexible hinge region; other site
447217002251	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217002252	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217002253	metal binding triad; other site
447217002254	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217002255	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
447217002256	active site
447217002257	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
447217002258	Response regulator receiver domain; Region: Response_reg; pfam00072
447217002259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002260	active site
447217002261	phosphorylation site [posttranslational modification]
447217002262	intermolecular recognition site; other site
447217002263	dimerization interface [polypeptide binding]; other site
447217002264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002265	NAD(P) binding site [chemical binding]; other site
447217002266	active site
447217002267	Domain of unknown function DUF21; Region: DUF21; pfam01595
447217002268	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
447217002269	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217002270	Transporter associated domain; Region: CorC_HlyC; smart01091
447217002271	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
447217002272	Methyltransferase domain; Region: Methyltransf_31; pfam13847
447217002273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217002274	S-adenosylmethionine binding site [chemical binding]; other site
447217002275	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
447217002276	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
447217002277	TPP-binding site [chemical binding]; other site
447217002278	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
447217002279	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217002280	E3 interaction surface; other site
447217002281	lipoyl attachment site [posttranslational modification]; other site
447217002282	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
447217002283	Protein of unknown function DUF72; Region: DUF72; pfam01904
447217002284	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
447217002285	active site
447217002286	DNA binding site [nucleotide binding]
447217002287	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
447217002288	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
447217002289	DNA binding site [nucleotide binding]
447217002290	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
447217002291	nucleotide binding site [chemical binding]; other site
447217002292	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
447217002293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002294	ATP binding site [chemical binding]; other site
447217002295	putative Mg++ binding site [ion binding]; other site
447217002296	helicase superfamily c-terminal domain; Region: HELICc; smart00490
447217002297	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
447217002298	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
447217002299	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
447217002300	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
447217002301	putative dimer interface [polypeptide binding]; other site
447217002302	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
447217002303	Clp amino terminal domain; Region: Clp_N; pfam02861
447217002304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002305	Walker A motif; other site
447217002306	ATP binding site [chemical binding]; other site
447217002307	Walker B motif; other site
447217002308	arginine finger; other site
447217002309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002310	Walker A motif; other site
447217002311	ATP binding site [chemical binding]; other site
447217002312	Walker B motif; other site
447217002313	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
447217002314	Uncharacterized conserved protein [Function unknown]; Region: COG2127
447217002315	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217002316	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
447217002317	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
447217002318	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217002319	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002320	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217002321	DNA binding residues [nucleotide binding]
447217002322	Putative zinc-finger; Region: zf-HC2; pfam13490
447217002323	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217002324	heme-binding residues [chemical binding]; other site
447217002325	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002326	molybdopterin cofactor binding site; other site
447217002327	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002328	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
447217002329	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
447217002330	4Fe-4S binding domain; Region: Fer4_2; pfam12797
447217002331	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
447217002332	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
447217002333	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
447217002334	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
447217002335	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
447217002336	Cu(I) binding site [ion binding]; other site
447217002337	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
447217002338	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
447217002339	Cytochrome c; Region: Cytochrom_C; pfam00034
447217002340	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
447217002341	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
447217002342	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
447217002343	Subunit I/III interface [polypeptide binding]; other site
447217002344	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
447217002345	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
447217002346	thiamine pyrophosphate protein; Provisional; Region: PRK08273
447217002347	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
447217002348	PYR/PP interface [polypeptide binding]; other site
447217002349	dimer interface [polypeptide binding]; other site
447217002350	tetramer interface [polypeptide binding]; other site
447217002351	TPP binding site [chemical binding]; other site
447217002352	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
447217002353	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
447217002354	TPP-binding site [chemical binding]; other site
447217002355	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
447217002356	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
447217002357	metal binding site [ion binding]; metal-binding site
447217002358	substrate binding pocket [chemical binding]; other site
447217002359	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217002360	FAD binding domain; Region: FAD_binding_4; pfam01565
447217002361	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217002362	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
447217002363	putative ADP-ribose binding site [chemical binding]; other site
447217002364	putative active site [active]
447217002365	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002367	active site
447217002368	phosphorylation site [posttranslational modification]
447217002369	intermolecular recognition site; other site
447217002370	dimerization interface [polypeptide binding]; other site
447217002371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002372	Walker A motif; other site
447217002373	ATP binding site [chemical binding]; other site
447217002374	Walker B motif; other site
447217002375	arginine finger; other site
447217002376	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217002377	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217002378	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217002379	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
447217002380	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
447217002381	active site
447217002382	DNA binding site [nucleotide binding]
447217002383	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
447217002384	DNA binding site [nucleotide binding]
447217002385	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
447217002386	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
447217002387	active site
447217002388	dimer interface [polypeptide binding]; other site
447217002389	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
447217002390	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
447217002391	active site
447217002392	FMN binding site [chemical binding]; other site
447217002393	substrate binding site [chemical binding]; other site
447217002394	3Fe-4S cluster binding site [ion binding]; other site
447217002395	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
447217002396	domain interface; other site
447217002397	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
447217002398	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217002399	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
447217002400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002402	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
447217002403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217002404	FeS/SAM binding site; other site
447217002405	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
447217002406	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
447217002407	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
447217002408	4Fe-4S binding domain; Region: Fer4; pfam00037
447217002409	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217002410	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002411	molybdopterin cofactor binding site; other site
447217002412	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002413	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002414	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217002415	molybdopterin cofactor binding site; other site
447217002416	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
447217002417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
447217002418	Walker A motif; other site
447217002419	ATP binding site [chemical binding]; other site
447217002420	Family description; Region: UvrD_C_2; pfam13538
447217002421	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
447217002422	dimer interface [polypeptide binding]; other site
447217002423	catalytic triad [active]
447217002424	peroxidatic and resolving cysteines [active]
447217002425	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217002426	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217002427	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217002428	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217002429	ABC transporter; Region: ABC_tran_2; pfam12848
447217002430	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217002431	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217002432	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217002433	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
447217002434	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
447217002435	Glutamate binding site [chemical binding]; other site
447217002436	NAD binding site [chemical binding]; other site
447217002437	catalytic residues [active]
447217002438	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002440	active site
447217002441	phosphorylation site [posttranslational modification]
447217002442	intermolecular recognition site; other site
447217002443	dimerization interface [polypeptide binding]; other site
447217002444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002445	Walker A motif; other site
447217002446	ATP binding site [chemical binding]; other site
447217002447	Walker B motif; other site
447217002448	arginine finger; other site
447217002449	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217002450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217002451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002452	dimer interface [polypeptide binding]; other site
447217002453	phosphorylation site [posttranslational modification]
447217002454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002455	ATP binding site [chemical binding]; other site
447217002456	Mg2+ binding site [ion binding]; other site
447217002457	G-X-G motif; other site
447217002458	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217002459	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
447217002460	Walker A/P-loop; other site
447217002461	ATP binding site [chemical binding]; other site
447217002462	Q-loop/lid; other site
447217002463	ABC transporter signature motif; other site
447217002464	Walker B; other site
447217002465	D-loop; other site
447217002466	H-loop/switch region; other site
447217002467	ABC-2 type transporter; Region: ABC2_membrane; cl17235
447217002468	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
447217002469	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217002470	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002471	ATP binding site [chemical binding]; other site
447217002472	putative Mg++ binding site [ion binding]; other site
447217002473	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217002474	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
447217002475	nucleotide binding region [chemical binding]; other site
447217002476	ATP-binding site [chemical binding]; other site
447217002477	HRDC domain; Region: HRDC; pfam00570
447217002478	YaeQ protein; Region: YaeQ; cl01913
447217002479	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
447217002480	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217002481	dimerization interface [polypeptide binding]; other site
447217002482	putative Zn2+ binding site [ion binding]; other site
447217002483	putative DNA binding site [nucleotide binding]; other site
447217002484	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
447217002485	putative ABC transporter; Region: ycf24; CHL00085
447217002486	FeS assembly ATPase SufC; Region: sufC; TIGR01978
447217002487	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
447217002488	Walker A/P-loop; other site
447217002489	ATP binding site [chemical binding]; other site
447217002490	Q-loop/lid; other site
447217002491	ABC transporter signature motif; other site
447217002492	Walker B; other site
447217002493	D-loop; other site
447217002494	H-loop/switch region; other site
447217002495	FeS assembly protein SufD; Region: sufD; TIGR01981
447217002496	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
447217002497	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217002498	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
447217002499	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217002500	catalytic residue [active]
447217002501	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
447217002502	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
447217002503	trimerization site [polypeptide binding]; other site
447217002504	active site
447217002505	Domain of unknown function DUF59; Region: DUF59; cl00941
447217002506	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217002507	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217002508	phosphopeptide binding site; other site
447217002509	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
447217002510	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217002511	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217002512	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217002513	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217002514	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217002515	protein binding site [polypeptide binding]; other site
447217002516	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
447217002517	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
447217002518	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217002519	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217002520	FtsX-like permease family; Region: FtsX; pfam02687
447217002521	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217002522	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217002523	protein binding site [polypeptide binding]; other site
447217002524	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217002525	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217002526	protein binding site [polypeptide binding]; other site
447217002527	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217002528	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217002529	DNA binding residues [nucleotide binding]
447217002530	dimerization interface [polypeptide binding]; other site
447217002531	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
447217002532	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217002533	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002534	active site
447217002535	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
447217002536	putative rRNA binding site [nucleotide binding]; other site
447217002537	TfuA-like protein; Region: TfuA; pfam07812
447217002538	YcaO-like family; Region: YcaO; pfam02624
447217002539	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
447217002540	hypothetical protein; Provisional; Region: PRK07907
447217002541	active site
447217002542	metal binding site [ion binding]; metal-binding site
447217002543	dimer interface [polypeptide binding]; other site
447217002544	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
447217002545	homodimer interface [polypeptide binding]; other site
447217002546	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
447217002547	active site pocket [active]
447217002548	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217002549	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
447217002550	Repair protein; Region: Repair_PSII; pfam04536
447217002551	Repair protein; Region: Repair_PSII; cl01535
447217002552	potassium/proton antiporter; Reviewed; Region: PRK05326
447217002553	TrkA-C domain; Region: TrkA_C; pfam02080
447217002554	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
447217002555	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217002556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217002557	non-specific DNA binding site [nucleotide binding]; other site
447217002558	salt bridge; other site
447217002559	sequence-specific DNA binding site [nucleotide binding]; other site
447217002560	Cupin domain; Region: Cupin_2; pfam07883
447217002561	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217002562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002563	active site
447217002564	phosphorylation site [posttranslational modification]
447217002565	intermolecular recognition site; other site
447217002566	dimerization interface [polypeptide binding]; other site
447217002567	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
447217002568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217002569	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
447217002570	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
447217002571	active site
447217002572	Substrate binding site; other site
447217002573	Mg++ binding site; other site
447217002574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217002575	S-adenosylmethionine binding site [chemical binding]; other site
447217002576	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
447217002577	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
447217002578	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217002579	ligand binding site [chemical binding]; other site
447217002580	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
447217002581	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
447217002582	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
447217002583	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
447217002584	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
447217002585	active site
447217002586	DNA binding site [nucleotide binding]
447217002587	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
447217002588	nucleotide binding site [chemical binding]; other site
447217002589	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
447217002590	Mechanosensitive ion channel; Region: MS_channel; pfam00924
447217002591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217002592	TPR motif; other site
447217002593	binding surface
447217002594	TPR repeat; Region: TPR_11; pfam13414
447217002595	CAAX protease self-immunity; Region: Abi; cl00558
447217002596	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
447217002597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002598	active site
447217002599	phosphorylation site [posttranslational modification]
447217002600	intermolecular recognition site; other site
447217002601	dimerization interface [polypeptide binding]; other site
447217002602	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217002603	DNA binding site [nucleotide binding]
447217002604	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
447217002605	GAF domain; Region: GAF_3; pfam13492
447217002606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002607	dimer interface [polypeptide binding]; other site
447217002608	phosphorylation site [posttranslational modification]
447217002609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002610	ATP binding site [chemical binding]; other site
447217002611	Mg2+ binding site [ion binding]; other site
447217002612	G-X-G motif; other site
447217002613	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
447217002614	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
447217002615	ligand binding site; other site
447217002616	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
447217002617	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
447217002618	dimerization interface [polypeptide binding]; other site
447217002619	Protein of unknown function (DUF420); Region: DUF420; pfam04238
447217002620	ABC-2 type transporter; Region: ABC2_membrane; cl17235
447217002621	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217002622	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
447217002623	Walker A/P-loop; other site
447217002624	ATP binding site [chemical binding]; other site
447217002625	Q-loop/lid; other site
447217002626	ABC transporter signature motif; other site
447217002627	Walker B; other site
447217002628	D-loop; other site
447217002629	H-loop/switch region; other site
447217002630	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
447217002631	UbiA prenyltransferase family; Region: UbiA; pfam01040
447217002632	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
447217002633	TIGR02300 family protein; Region: FYDLN_acid
447217002634	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
447217002635	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
447217002636	Ligand Binding Site [chemical binding]; other site
447217002637	Class I aldolases; Region: Aldolase_Class_I; cl17187
447217002638	catalytic residue [active]
447217002639	phosphopentomutase; Provisional; Region: PRK05362
447217002640	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
447217002641	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
447217002642	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
447217002643	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
447217002644	[4Fe-4S] binding site [ion binding]; other site
447217002645	molybdopterin cofactor binding site; other site
447217002646	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
447217002647	molybdopterin cofactor binding site; other site
447217002648	Cytochrome c552; Region: Cytochrom_C552; pfam02335
447217002649	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217002650	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
447217002651	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
447217002652	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217002653	Interdomain contacts; other site
447217002654	Cytokine receptor motif; other site
447217002655	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217002656	Interdomain contacts; other site
447217002657	Cytokine receptor motif; other site
447217002658	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
447217002659	hydrophobic ligand binding site; other site
447217002660	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
447217002661	anti sigma factor interaction site; other site
447217002662	regulatory phosphorylation site [posttranslational modification]; other site
447217002663	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217002664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217002665	ATP binding site [chemical binding]; other site
447217002666	Mg2+ binding site [ion binding]; other site
447217002667	G-X-G motif; other site
447217002668	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217002669	dimerization interface [polypeptide binding]; other site
447217002670	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
447217002671	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
447217002672	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
447217002673	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217002674	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
447217002675	urease subunit alpha; Reviewed; Region: ureC; PRK13207
447217002676	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
447217002677	subunit interactions [polypeptide binding]; other site
447217002678	active site
447217002679	flap region; other site
447217002680	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
447217002681	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
447217002682	alpha-gamma subunit interface [polypeptide binding]; other site
447217002683	beta-gamma subunit interface [polypeptide binding]; other site
447217002684	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
447217002685	alpha-beta subunit interface [polypeptide binding]; other site
447217002686	UreD urease accessory protein; Region: UreD; pfam01774
447217002687	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002689	active site
447217002690	phosphorylation site [posttranslational modification]
447217002691	intermolecular recognition site; other site
447217002692	dimerization interface [polypeptide binding]; other site
447217002693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002694	Walker A motif; other site
447217002695	ATP binding site [chemical binding]; other site
447217002696	Walker B motif; other site
447217002697	arginine finger; other site
447217002698	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217002699	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217002700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002701	dimer interface [polypeptide binding]; other site
447217002702	phosphorylation site [posttranslational modification]
447217002703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002704	ATP binding site [chemical binding]; other site
447217002705	Mg2+ binding site [ion binding]; other site
447217002706	G-X-G motif; other site
447217002707	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217002708	Caspase domain; Region: Peptidase_C14; pfam00656
447217002709	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
447217002710	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217002711	homodimer interface [polypeptide binding]; other site
447217002712	substrate-cofactor binding pocket; other site
447217002713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217002714	catalytic residue [active]
447217002715	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217002716	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217002717	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217002718	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
447217002719	acyl-activating enzyme (AAE) consensus motif; other site
447217002720	acyl-activating enzyme (AAE) consensus motif; other site
447217002721	putative AMP binding site [chemical binding]; other site
447217002722	putative active site [active]
447217002723	putative CoA binding site [chemical binding]; other site
447217002724	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
447217002725	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217002726	DTAP/Switch II; other site
447217002727	Switch I; other site
447217002728	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
447217002729	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217002730	DTAP/Switch II; other site
447217002731	Switch I; other site
447217002732	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
447217002733	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217002734	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217002735	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217002736	Magnesium ion binding site [ion binding]; other site
447217002737	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217002738	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217002739	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217002740	putative effector binding pocket; other site
447217002741	dimerization interface [polypeptide binding]; other site
447217002742	Uncharacterized conserved protein [Function unknown]; Region: COG2353
447217002743	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
447217002744	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
447217002745	putative active site [active]
447217002746	metal binding site [ion binding]; metal-binding site
447217002747	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
447217002748	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
447217002749	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
447217002750	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
447217002751	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
447217002752	active site
447217002753	catalytic site [active]
447217002754	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
447217002755	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
447217002756	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217002757	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
447217002758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
447217002759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217002760	hydroxyglutarate oxidase; Provisional; Region: PRK11728
447217002761	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
447217002762	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
447217002763	tetramer interface [polypeptide binding]; other site
447217002764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217002765	catalytic residue [active]
447217002766	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
447217002767	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
447217002768	catalytic residues [active]
447217002769	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217002770	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217002771	active site
447217002772	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
447217002773	hypothetical protein; Reviewed; Region: PRK09588
447217002774	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
447217002775	multidrug efflux protein; Reviewed; Region: PRK01766
447217002776	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
447217002777	cation binding site [ion binding]; other site
447217002778	K+ potassium transporter; Region: K_trans; cl15781
447217002779	potassium uptake protein; Region: kup; TIGR00794
447217002780	Transmembrane secretion effector; Region: MFS_3; pfam05977
447217002781	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
447217002782	active site
447217002783	putative DNA-binding cleft [nucleotide binding]; other site
447217002784	dimer interface [polypeptide binding]; other site
447217002785	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
447217002786	RuvA N terminal domain; Region: RuvA_N; pfam01330
447217002787	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
447217002788	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
447217002789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002790	Walker A motif; other site
447217002791	ATP binding site [chemical binding]; other site
447217002792	Walker B motif; other site
447217002793	arginine finger; other site
447217002794	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
447217002795	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
447217002796	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
447217002797	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
447217002798	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
447217002799	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
447217002800	putative hydrophobic ligand binding site [chemical binding]; other site
447217002801	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
447217002802	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
447217002803	nucleotide binding site [chemical binding]; other site
447217002804	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
447217002805	putative DNA binding site [nucleotide binding]; other site
447217002806	putative homodimer interface [polypeptide binding]; other site
447217002807	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
447217002808	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
447217002809	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
447217002810	hypothetical protein; Provisional; Region: PRK10621
447217002811	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
447217002812	Response regulator receiver domain; Region: Response_reg; pfam00072
447217002813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002814	active site
447217002815	phosphorylation site [posttranslational modification]
447217002816	intermolecular recognition site; other site
447217002817	dimerization interface [polypeptide binding]; other site
447217002818	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
447217002819	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
447217002820	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
447217002821	DNA binding site [nucleotide binding]
447217002822	active site
447217002823	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
447217002824	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
447217002825	AlkA N-terminal domain; Region: AlkA_N; pfam06029
447217002826	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
447217002827	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217002828	helix-hairpin-helix signature motif; other site
447217002829	substrate binding pocket [chemical binding]; other site
447217002830	active site
447217002831	Cupin domain; Region: Cupin_2; cl17218
447217002832	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
447217002833	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217002834	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
447217002835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002836	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217002837	Walker A motif; other site
447217002838	ATP binding site [chemical binding]; other site
447217002839	Walker B motif; other site
447217002840	arginine finger; other site
447217002841	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217002842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002843	putative substrate translocation pore; other site
447217002844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217002845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217002846	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002847	dimerization interface [polypeptide binding]; other site
447217002848	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
447217002849	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
447217002850	Peptidase family M48; Region: Peptidase_M48; pfam01435
447217002851	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
447217002852	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217002853	DNA-binding site [nucleotide binding]; DNA binding site
447217002854	RNA-binding motif; other site
447217002855	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217002856	active site
447217002857	metal binding site [ion binding]; metal-binding site
447217002858	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
447217002859	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217002860	PLD-like domain; Region: PLDc_2; pfam13091
447217002861	putative active site [active]
447217002862	catalytic site [active]
447217002863	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
447217002864	PLD-like domain; Region: PLDc_2; pfam13091
447217002865	putative active site [active]
447217002866	catalytic site [active]
447217002867	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
447217002868	homodimer interaction site [polypeptide binding]; other site
447217002869	cofactor binding site; other site
447217002870	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
447217002871	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
447217002872	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
447217002873	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
447217002874	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
447217002875	putative ligand binding site [chemical binding]; other site
447217002876	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002877	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002878	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002879	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002880	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002881	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002882	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002883	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002884	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002885	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002886	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002887	CoA binding domain; Region: CoA_binding_2; pfam13380
447217002888	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
447217002889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217002890	Coenzyme A binding pocket [chemical binding]; other site
447217002891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
447217002892	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
447217002893	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
447217002894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217002895	Walker A/P-loop; other site
447217002896	ATP binding site [chemical binding]; other site
447217002897	Q-loop/lid; other site
447217002898	ABC transporter signature motif; other site
447217002899	Walker B; other site
447217002900	D-loop; other site
447217002901	H-loop/switch region; other site
447217002902	TOBE domain; Region: TOBE; cl01440
447217002903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217002904	putative PBP binding loops; other site
447217002905	ABC-ATPase subunit interface; other site
447217002906	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217002907	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
447217002908	Helix-turn-helix domain; Region: HTH_17; pfam12728
447217002909	PBP superfamily domain; Region: PBP_like; pfam12727
447217002910	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
447217002911	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
447217002912	putative ligand binding site [chemical binding]; other site
447217002913	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
447217002914	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
447217002915	TM-ABC transporter signature motif; other site
447217002916	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
447217002917	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
447217002918	TM-ABC transporter signature motif; other site
447217002919	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
447217002920	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
447217002921	Walker A/P-loop; other site
447217002922	ATP binding site [chemical binding]; other site
447217002923	Q-loop/lid; other site
447217002924	ABC transporter signature motif; other site
447217002925	Walker B; other site
447217002926	D-loop; other site
447217002927	H-loop/switch region; other site
447217002928	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
447217002929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217002930	active site
447217002931	YCII-related domain; Region: YCII; cl00999
447217002932	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217002933	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217002934	RibD C-terminal domain; Region: RibD_C; cl17279
447217002935	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002936	active site
447217002937	HTH domain; Region: HTH_11; pfam08279
447217002938	WYL domain; Region: WYL; pfam13280
447217002939	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002940	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217002941	NAD(P) binding site [chemical binding]; other site
447217002942	active site
447217002943	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
447217002944	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
447217002945	PYR/PP interface [polypeptide binding]; other site
447217002946	dimer interface [polypeptide binding]; other site
447217002947	TPP binding site [chemical binding]; other site
447217002948	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
447217002949	TPP-binding site [chemical binding]; other site
447217002950	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
447217002951	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217002952	putative ADP-binding pocket [chemical binding]; other site
447217002953	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
447217002954	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
447217002955	Outer membrane efflux protein; Region: OEP; pfam02321
447217002956	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217002957	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217002958	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217002959	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217002960	Fatty acid desaturase; Region: FA_desaturase; pfam00487
447217002961	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
447217002962	putative di-iron ligands [ion binding]; other site
447217002963	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
447217002964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217002965	Coenzyme A binding pocket [chemical binding]; other site
447217002966	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
447217002967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217002968	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002969	dimerization interface [polypeptide binding]; other site
447217002970	rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179
447217002971	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
447217002972	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217002973	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
447217002974	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
447217002975	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217002976	active site
447217002977	nucleotide binding site [chemical binding]; other site
447217002978	HIGH motif; other site
447217002979	KMSKS motif; other site
447217002980	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
447217002981	CoA-binding site [chemical binding]; other site
447217002982	ATP-binding [chemical binding]; other site
447217002983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
447217002984	Isochorismatase family; Region: Isochorismatase; pfam00857
447217002985	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
447217002986	catalytic triad [active]
447217002987	dimer interface [polypeptide binding]; other site
447217002988	conserved cis-peptide bond; other site
447217002989	4Fe-4S binding domain; Region: Fer4; cl02805
447217002990	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
447217002991	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
447217002992	FtsJ-like methyltransferase; Region: FtsJ; cl17430
447217002993	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
447217002994	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
447217002995	active site
447217002996	HIGH motif; other site
447217002997	dimer interface [polypeptide binding]; other site
447217002998	KMSKS motif; other site
447217002999	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
447217003000	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217003001	putative active site [active]
447217003002	metal binding site [ion binding]; metal-binding site
447217003003	homodimer binding site [polypeptide binding]; other site
447217003004	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
447217003005	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
447217003006	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217003007	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003008	active site
447217003009	ATP binding site [chemical binding]; other site
447217003010	substrate binding site [chemical binding]; other site
447217003011	activation loop (A-loop); other site
447217003012	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
447217003013	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
447217003014	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217003015	catalytic residue [active]
447217003016	DHH family; Region: DHH; pfam01368
447217003017	endonuclease IV; Provisional; Region: PRK01060
447217003018	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
447217003019	AP (apurinic/apyrimidinic) site pocket; other site
447217003020	DNA interaction; other site
447217003021	Metal-binding active site; metal-binding site
447217003022	Fic/DOC family; Region: Fic; pfam02661
447217003023	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
447217003024	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
447217003025	homodimer interface [polypeptide binding]; other site
447217003026	substrate-cofactor binding pocket; other site
447217003027	catalytic residue [active]
447217003028	Patatin-like phospholipase; Region: Patatin; pfam01734
447217003029	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217003030	metal binding triad; other site
447217003031	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217003032	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217003033	metal binding triad; other site
447217003034	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217003035	heavy-Cys/GCP-CTERM domain protein; Region: heavy_Cys_GCP; TIGR04292
447217003036	Transposase domain (DUF772); Region: DUF772; pfam05598
447217003037	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217003038	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217003039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
447217003040	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217003041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217003042	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217003043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003044	active site
447217003045	phosphorylation site [posttranslational modification]
447217003046	intermolecular recognition site; other site
447217003047	dimerization interface [polypeptide binding]; other site
447217003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003049	Walker A motif; other site
447217003050	ATP binding site [chemical binding]; other site
447217003051	Walker B motif; other site
447217003052	arginine finger; other site
447217003053	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217003054	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
447217003055	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
447217003056	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
447217003057	active site
447217003058	catalytic site [active]
447217003059	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
447217003060	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
447217003061	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217003062	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
447217003063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217003064	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
447217003065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217003066	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
447217003067	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217003068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003069	NAD(P) binding site [chemical binding]; other site
447217003070	active site
447217003071	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003072	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
447217003073	NAD(P) binding site [chemical binding]; other site
447217003074	active site
447217003075	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217003076	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
447217003077	putative NAD(P) binding site [chemical binding]; other site
447217003078	catalytic Zn binding site [ion binding]; other site
447217003079	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217003080	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
447217003081	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
447217003082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217003083	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217003084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217003085	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
447217003086	Domain of unknown function DUF20; Region: UPF0118; pfam01594
447217003087	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
447217003088	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
447217003089	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
447217003090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217003091	Walker A/P-loop; other site
447217003092	ATP binding site [chemical binding]; other site
447217003093	Q-loop/lid; other site
447217003094	ABC transporter signature motif; other site
447217003095	Walker B; other site
447217003096	D-loop; other site
447217003097	H-loop/switch region; other site
447217003098	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217003099	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
447217003100	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
447217003101	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217003102	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217003103	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217003104	DNA binding residues [nucleotide binding]
447217003105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003106	malonic semialdehyde reductase; Provisional; Region: PRK10538
447217003107	NAD(P) binding site [chemical binding]; other site
447217003108	active site
447217003109	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217003110	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217003111	dimerization interface [polypeptide binding]; other site
447217003112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217003113	dimer interface [polypeptide binding]; other site
447217003114	phosphorylation site [posttranslational modification]
447217003115	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
447217003116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217003117	ATP binding site [chemical binding]; other site
447217003118	Mg2+ binding site [ion binding]; other site
447217003119	G-X-G motif; other site
447217003120	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003121	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217003122	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003123	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217003124	active site
447217003125	ATP binding site [chemical binding]; other site
447217003126	substrate binding site [chemical binding]; other site
447217003127	activation loop (A-loop); other site
447217003128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
447217003129	Uncharacterized conserved protein [Function unknown]; Region: COG1543
447217003130	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
447217003131	active site
447217003132	substrate binding site [chemical binding]; other site
447217003133	catalytic site [active]
447217003134	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
447217003135	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
447217003136	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
447217003137	dimer interface [polypeptide binding]; other site
447217003138	putative anticodon binding site; other site
447217003139	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
447217003140	motif 1; other site
447217003141	active site
447217003142	motif 2; other site
447217003143	motif 3; other site
447217003144	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217003145	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217003146	FtsX-like permease family; Region: FtsX; pfam02687
447217003147	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
447217003148	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217003149	Walker A/P-loop; other site
447217003150	ATP binding site [chemical binding]; other site
447217003151	Q-loop/lid; other site
447217003152	ABC transporter signature motif; other site
447217003153	Walker B; other site
447217003154	D-loop; other site
447217003155	H-loop/switch region; other site
447217003156	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003157	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
447217003158	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003159	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003160	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003161	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
447217003162	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217003163	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
447217003164	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
447217003165	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
447217003166	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
447217003167	trimer interface [polypeptide binding]; other site
447217003168	active site
447217003169	UDP-GlcNAc binding site [chemical binding]; other site
447217003170	lipid binding site [chemical binding]; lipid-binding site
447217003171	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
447217003172	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
447217003173	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
447217003174	active site
447217003175	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
447217003176	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
447217003177	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
447217003178	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
447217003179	substrate binding site [chemical binding]; other site
447217003180	active site
447217003181	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
447217003182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217003183	FeS/SAM binding site; other site
447217003184	HemN C-terminal domain; Region: HemN_C; pfam06969
447217003185	Ferrochelatase; Region: Ferrochelatase; pfam00762
447217003186	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
447217003187	C-terminal domain interface [polypeptide binding]; other site
447217003188	active site
447217003189	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
447217003190	active site
447217003191	N-terminal domain interface [polypeptide binding]; other site
447217003192	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217003193	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217003194	active site
447217003195	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217003196	HSP70 interaction site [polypeptide binding]; other site
447217003197	TPR repeat; Region: TPR_11; pfam13414
447217003198	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
447217003199	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
447217003200	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
447217003201	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
447217003202	generic binding surface II; other site
447217003203	generic binding surface I; other site
447217003204	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
447217003205	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003207	active site
447217003208	phosphorylation site [posttranslational modification]
447217003209	intermolecular recognition site; other site
447217003210	dimerization interface [polypeptide binding]; other site
447217003211	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
447217003212	substrate binding pocket [chemical binding]; other site
447217003213	aspartate-rich region 1; other site
447217003214	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
447217003215	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
447217003216	TPP-binding site; other site
447217003217	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
447217003218	PYR/PP interface [polypeptide binding]; other site
447217003219	dimer interface [polypeptide binding]; other site
447217003220	TPP binding site [chemical binding]; other site
447217003221	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
447217003222	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
447217003223	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217003224	RNA binding surface [nucleotide binding]; other site
447217003225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217003226	S-adenosylmethionine binding site [chemical binding]; other site
447217003227	ribosome maturation protein RimP; Reviewed; Region: PRK00092
447217003228	Sm and related proteins; Region: Sm_like; cl00259
447217003229	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
447217003230	putative oligomer interface [polypeptide binding]; other site
447217003231	putative RNA binding site [nucleotide binding]; other site
447217003232	NusA N-terminal domain; Region: NusA_N; pfam08529
447217003233	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
447217003234	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
447217003235	RNA binding site [nucleotide binding]; other site
447217003236	homodimer interface [polypeptide binding]; other site
447217003237	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
447217003238	G-X-X-G motif; other site
447217003239	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
447217003240	G-X-X-G motif; other site
447217003241	Protein of unknown function (DUF448); Region: DUF448; pfam04296
447217003242	putative RNA binding cleft [nucleotide binding]; other site
447217003243	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
447217003244	translation initiation factor IF-2; Region: IF-2; TIGR00487
447217003245	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
447217003246	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
447217003247	G1 box; other site
447217003248	putative GEF interaction site [polypeptide binding]; other site
447217003249	GTP/Mg2+ binding site [chemical binding]; other site
447217003250	Switch I region; other site
447217003251	G2 box; other site
447217003252	G3 box; other site
447217003253	Switch II region; other site
447217003254	G4 box; other site
447217003255	G5 box; other site
447217003256	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
447217003257	Translation-initiation factor 2; Region: IF-2; pfam11987
447217003258	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
447217003259	Protein of unknown function (DUF503); Region: DUF503; pfam04456
447217003260	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
447217003261	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
447217003262	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
447217003263	RNA binding site [nucleotide binding]; other site
447217003264	active site
447217003265	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
447217003266	16S/18S rRNA binding site [nucleotide binding]; other site
447217003267	S13e-L30e interaction site [polypeptide binding]; other site
447217003268	25S rRNA binding site [nucleotide binding]; other site
447217003269	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
447217003270	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
447217003271	RNase E interface [polypeptide binding]; other site
447217003272	trimer interface [polypeptide binding]; other site
447217003273	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
447217003274	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
447217003275	RNase E interface [polypeptide binding]; other site
447217003276	trimer interface [polypeptide binding]; other site
447217003277	active site
447217003278	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
447217003279	putative nucleic acid binding region [nucleotide binding]; other site
447217003280	G-X-X-G motif; other site
447217003281	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
447217003282	RNA binding site [nucleotide binding]; other site
447217003283	domain interface; other site
447217003284	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
447217003285	trimer interface [polypeptide binding]; other site
447217003286	active site
447217003287	adenylosuccinate lyase; Provisional; Region: PRK07492
447217003288	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
447217003289	tetramer interface [polypeptide binding]; other site
447217003290	active site
447217003291	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217003292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217003293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217003294	dimer interface [polypeptide binding]; other site
447217003295	phosphorylation site [posttranslational modification]
447217003296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217003297	ATP binding site [chemical binding]; other site
447217003298	Mg2+ binding site [ion binding]; other site
447217003299	G-X-G motif; other site
447217003300	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
447217003301	ATP binding site [chemical binding]; other site
447217003302	active site
447217003303	substrate binding site [chemical binding]; other site
447217003304	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
447217003305	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
447217003306	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217003307	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217003308	protein binding site [polypeptide binding]; other site
447217003309	phosphoglycolate phosphatase; Provisional; Region: PRK13222
447217003310	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217003311	motif II; other site
447217003312	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217003313	dimerization interface [polypeptide binding]; other site
447217003314	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
447217003315	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003316	Zn2+ binding site [ion binding]; other site
447217003317	Mg2+ binding site [ion binding]; other site
447217003318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003319	active site
447217003320	phosphorylation site [posttranslational modification]
447217003321	intermolecular recognition site; other site
447217003322	dimerization interface [polypeptide binding]; other site
447217003323	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
447217003324	MoaE interaction surface [polypeptide binding]; other site
447217003325	MoeB interaction surface [polypeptide binding]; other site
447217003326	thiocarboxylated glycine; other site
447217003327	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
447217003328	MoaE homodimer interface [polypeptide binding]; other site
447217003329	MoaD interaction [polypeptide binding]; other site
447217003330	active site residues [active]
447217003331	RIP metalloprotease RseP; Region: TIGR00054
447217003332	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217003333	active site
447217003334	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217003335	protein binding site [polypeptide binding]; other site
447217003336	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
447217003337	putative substrate binding region [chemical binding]; other site
447217003338	AMMECR1; Region: AMMECR1; pfam01871
447217003339	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
447217003340	nudix motif; other site
447217003341	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
447217003342	active site clefts [active]
447217003343	zinc binding site [ion binding]; other site
447217003344	dimer interface [polypeptide binding]; other site
447217003345	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
447217003346	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
447217003347	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
447217003348	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
447217003349	EamA-like transporter family; Region: EamA; pfam00892
447217003350	EamA-like transporter family; Region: EamA; pfam00892
447217003351	PAS fold; Region: PAS_4; pfam08448
447217003352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217003353	putative active site [active]
447217003354	heme pocket [chemical binding]; other site
447217003355	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217003356	PAS domain; Region: PAS; smart00091
447217003357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217003358	dimer interface [polypeptide binding]; other site
447217003359	phosphorylation site [posttranslational modification]
447217003360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217003361	ATP binding site [chemical binding]; other site
447217003362	Mg2+ binding site [ion binding]; other site
447217003363	G-X-G motif; other site
447217003364	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217003365	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217003366	active site
447217003367	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
447217003368	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217003369	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003370	active site
447217003371	ATP binding site [chemical binding]; other site
447217003372	substrate binding site [chemical binding]; other site
447217003373	activation loop (A-loop); other site
447217003374	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
447217003375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003376	active site
447217003377	phosphorylation site [posttranslational modification]
447217003378	intermolecular recognition site; other site
447217003379	dimerization interface [polypeptide binding]; other site
447217003380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003381	Zn2+ binding site [ion binding]; other site
447217003382	Mg2+ binding site [ion binding]; other site
447217003383	transcription termination factor Rho; Provisional; Region: PRK12608
447217003384	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217003385	Walker A motif; other site
447217003386	ATP binding site [chemical binding]; other site
447217003387	Walker B motif; other site
447217003388	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
447217003389	oligomer interface [polypeptide binding]; other site
447217003390	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
447217003391	tandem repeat interface [polypeptide binding]; other site
447217003392	active site residues [active]
447217003393	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
447217003394	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
447217003395	tandem repeat interface [polypeptide binding]; other site
447217003396	oligomer interface [polypeptide binding]; other site
447217003397	active site residues [active]
447217003398	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
447217003399	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217003400	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
447217003401	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
447217003402	active site
447217003403	Zn binding site [ion binding]; other site
447217003404	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217003405	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003406	phosphopeptide binding site; other site
447217003407	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
447217003408	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
447217003409	NAD(P) binding site [chemical binding]; other site
447217003410	catalytic residues [active]
447217003411	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
447217003412	putative active site [active]
447217003413	putative metal binding site [ion binding]; other site
447217003414	Uncharacterized conserved protein [Function unknown]; Region: COG3342
447217003415	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
447217003416	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
447217003417	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217003418	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
447217003419	dimer interface [polypeptide binding]; other site
447217003420	decamer (pentamer of dimers) interface [polypeptide binding]; other site
447217003421	catalytic triad [active]
447217003422	peroxidatic and resolving cysteines [active]
447217003423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003424	non-specific DNA binding site [nucleotide binding]; other site
447217003425	salt bridge; other site
447217003426	sequence-specific DNA binding site [nucleotide binding]; other site
447217003427	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
447217003428	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217003429	dimer interface [polypeptide binding]; other site
447217003430	catalytic triad [active]
447217003431	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355
447217003432	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217003433	Haemolysin-III related; Region: HlyIII; pfam03006
447217003434	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
447217003435	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217003436	G1 box; other site
447217003437	GTP/Mg2+ binding site [chemical binding]; other site
447217003438	G2 box; other site
447217003439	Switch I region; other site
447217003440	G3 box; other site
447217003441	Switch II region; other site
447217003442	G4 box; other site
447217003443	G5 box; other site
447217003444	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
447217003445	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
447217003446	heterotetramer interface [polypeptide binding]; other site
447217003447	active site pocket [active]
447217003448	cleavage site
447217003449	Methyltransferase domain; Region: Methyltransf_31; pfam13847
447217003450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217003451	S-adenosylmethionine binding site [chemical binding]; other site
447217003452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217003453	dimerization interface [polypeptide binding]; other site
447217003454	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217003455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217003456	dimer interface [polypeptide binding]; other site
447217003457	putative CheW interface [polypeptide binding]; other site
447217003458	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217003459	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217003460	putative NAD(P) binding site [chemical binding]; other site
447217003461	putative substrate binding site [chemical binding]; other site
447217003462	catalytic Zn binding site [ion binding]; other site
447217003463	structural Zn binding site [ion binding]; other site
447217003464	dimer interface [polypeptide binding]; other site
447217003465	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
447217003466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003467	NAD(P) binding site [chemical binding]; other site
447217003468	active site
447217003469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003470	NAD(P) binding site [chemical binding]; other site
447217003471	active site
447217003472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003473	active site
447217003474	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
447217003475	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217003476	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217003477	acyl-activating enzyme (AAE) consensus motif; other site
447217003478	AMP binding site [chemical binding]; other site
447217003479	active site
447217003480	CoA binding site [chemical binding]; other site
447217003481	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
447217003482	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217003483	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217003484	putative acyl-acceptor binding pocket; other site
447217003485	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
447217003486	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
447217003487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217003488	motif II; other site
447217003489	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
447217003490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003491	NAD(P) binding site [chemical binding]; other site
447217003492	active site
447217003493	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
447217003494	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
447217003495	putative [4Fe-4S] binding site [ion binding]; other site
447217003496	putative molybdopterin cofactor binding site [chemical binding]; other site
447217003497	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
447217003498	putative molybdopterin cofactor binding site; other site
447217003499	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217003500	Low-spin heme binding site [chemical binding]; other site
447217003501	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
447217003502	D-pathway; other site
447217003503	Putative water exit pathway; other site
447217003504	Binuclear center (active site) [active]
447217003505	K-pathway; other site
447217003506	Putative proton exit pathway; other site
447217003507	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
447217003508	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
447217003509	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
447217003510	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
447217003511	4Fe-4S binding domain; Region: Fer4_5; pfam12801
447217003512	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
447217003513	4Fe-4S binding domain; Region: Fer4_6; pfam12837
447217003514	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
447217003515	FixH; Region: FixH; pfam05751
447217003516	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
447217003517	YtkA-like; Region: YtkA; pfam13115
447217003518	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217003519	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
447217003520	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
447217003521	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
447217003522	metal-binding site [ion binding]
447217003523	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217003524	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
447217003525	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
447217003526	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
447217003527	substrate binding site [chemical binding]; other site
447217003528	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
447217003529	substrate binding site [chemical binding]; other site
447217003530	ligand binding site [chemical binding]; other site
447217003531	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
447217003532	nudix motif; other site
447217003533	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217003534	aspartate ammonia-lyase; Provisional; Region: PRK13353
447217003535	Aspartase; Region: Aspartase; cd01357
447217003536	active sites [active]
447217003537	tetramer interface [polypeptide binding]; other site
447217003538	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217003539	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
447217003540	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217003541	active site
447217003542	HIGH motif; other site
447217003543	nucleotide binding site [chemical binding]; other site
447217003544	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
447217003545	KMSKS motif; other site
447217003546	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
447217003547	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
447217003548	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
447217003549	active site
447217003550	HIGH motif; other site
447217003551	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
447217003552	active site
447217003553	KMSKS motif; other site
447217003554	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217003555	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217003556	active site
447217003557	active site
447217003558	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
447217003559	putative ligand binding pocket/active site [active]
447217003560	putative metal binding site [ion binding]; other site
447217003561	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003563	active site
447217003564	phosphorylation site [posttranslational modification]
447217003565	intermolecular recognition site; other site
447217003566	dimerization interface [polypeptide binding]; other site
447217003567	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
447217003568	CAAX protease self-immunity; Region: Abi; pfam02517
447217003569	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
447217003570	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003571	Zn2+ binding site [ion binding]; other site
447217003572	Mg2+ binding site [ion binding]; other site
447217003573	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
447217003574	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
447217003575	putative dimer interface [polypeptide binding]; other site
447217003576	putative active site [active]
447217003577	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217003578	nucleotide binding site [chemical binding]; other site
447217003579	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
447217003580	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217003581	HSP70 interaction site [polypeptide binding]; other site
447217003582	Colicin V production protein; Region: Colicin_V; pfam02674
447217003583	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217003584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003585	Walker A motif; other site
447217003586	ATP binding site [chemical binding]; other site
447217003587	Walker B motif; other site
447217003588	agmatinase; Region: agmatinase; TIGR01230
447217003589	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
447217003590	putative active site [active]
447217003591	Mn binding site [ion binding]; other site
447217003592	Predicted transcriptional regulator [Transcription]; Region: COG1959
447217003593	Transcriptional regulator; Region: Rrf2; pfam02082
447217003594	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
447217003595	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
447217003596	active site
447217003597	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
447217003598	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
447217003599	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217003600	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
447217003601	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217003602	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
447217003603	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217003604	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217003605	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
447217003606	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
447217003607	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
447217003608	4Fe-4S binding domain; Region: Fer4; pfam00037
447217003609	4Fe-4S binding domain; Region: Fer4; pfam00037
447217003610	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
447217003611	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
447217003612	NADH dehydrogenase subunit D; Validated; Region: PRK06075
447217003613	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
447217003614	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
447217003615	NADH dehydrogenase subunit B; Provisional; Region: PRK14818
447217003616	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
447217003617	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
447217003618	NADH dehydrogenase subunit B; Provisional; Region: PRK14817
447217003619	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
447217003620	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
447217003621	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
447217003622	NADH dehydrogenase subunit D; Validated; Region: PRK06075
447217003623	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217003624	catalytic loop [active]
447217003625	iron binding site [ion binding]; other site
447217003626	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
447217003627	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217003628	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217003629	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
447217003630	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
447217003631	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
447217003632	4Fe-4S binding domain; Region: Fer4; pfam00037
447217003633	muropeptide transporter; Validated; Region: ampG; cl17669
447217003634	muropeptide transporter; Reviewed; Region: ampG; PRK11902
447217003635	hypothetical protein; Provisional; Region: PRK08609
447217003636	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
447217003637	active site
447217003638	primer binding site [nucleotide binding]; other site
447217003639	NTP  binding site [chemical binding]; other site
447217003640	metal binding triad [ion binding]; metal-binding site
447217003641	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
447217003642	active site
447217003643	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
447217003644	MPT binding site; other site
447217003645	trimer interface [polypeptide binding]; other site
447217003646	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
447217003647	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
447217003648	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
447217003649	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
447217003650	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
447217003651	Double zinc ribbon; Region: DZR; pfam12773
447217003652	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
447217003653	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217003654	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003655	phosphopeptide binding site; other site
447217003656	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217003657	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003658	phosphopeptide binding site; other site
447217003659	Domain of unknown function DUF77; Region: DUF77; pfam01910
447217003660	Double zinc ribbon; Region: DZR; pfam12773
447217003661	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
447217003662	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003663	phosphopeptide binding site; other site
447217003664	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
447217003665	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003666	Zn2+ binding site [ion binding]; other site
447217003667	Mg2+ binding site [ion binding]; other site
447217003668	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
447217003669	synthetase active site [active]
447217003670	NTP binding site [chemical binding]; other site
447217003671	metal binding site [ion binding]; metal-binding site
447217003672	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
447217003673	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
447217003674	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
447217003675	homotrimer interaction site [polypeptide binding]; other site
447217003676	putative active site [active]
447217003677	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
447217003678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217003679	FeS/SAM binding site; other site
447217003680	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
447217003681	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
447217003682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
447217003683	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
447217003684	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217003685	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
447217003686	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217003687	Stage II sporulation protein; Region: SpoIID; pfam08486
447217003688	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
447217003689	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
447217003690	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
447217003691	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
447217003692	Preprotein translocase subunit; Region: YajC; pfam02699
447217003693	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
447217003694	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
447217003695	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
447217003696	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
447217003697	Protein export membrane protein; Region: SecD_SecF; pfam02355
447217003698	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003700	active site
447217003701	phosphorylation site [posttranslational modification]
447217003702	intermolecular recognition site; other site
447217003703	dimerization interface [polypeptide binding]; other site
447217003704	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
447217003705	DHH family; Region: DHH; pfam01368
447217003706	DHHA1 domain; Region: DHHA1; pfam02272
447217003707	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
447217003708	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
447217003709	NADP binding site [chemical binding]; other site
447217003710	dimer interface [polypeptide binding]; other site
447217003711	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
447217003712	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
447217003713	dimer interface [polypeptide binding]; other site
447217003714	anticodon binding site; other site
447217003715	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
447217003716	homodimer interface [polypeptide binding]; other site
447217003717	motif 1; other site
447217003718	active site
447217003719	motif 2; other site
447217003720	GAD domain; Region: GAD; pfam02938
447217003721	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217003722	active site
447217003723	motif 3; other site
447217003724	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
447217003725	hydroxyglutarate oxidase; Provisional; Region: PRK11728
447217003726	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
447217003727	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
447217003728	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
447217003729	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
447217003730	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
447217003731	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
447217003732	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
447217003733	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217003734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003735	non-specific DNA binding site [nucleotide binding]; other site
447217003736	salt bridge; other site
447217003737	sequence-specific DNA binding site [nucleotide binding]; other site
447217003738	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217003739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003740	non-specific DNA binding site [nucleotide binding]; other site
447217003741	salt bridge; other site
447217003742	sequence-specific DNA binding site [nucleotide binding]; other site
447217003743	NHL repeat; Region: NHL; pfam01436
447217003744	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
447217003745	RHS Repeat; Region: RHS_repeat; pfam05593
447217003746	RHS Repeat; Region: RHS_repeat; cl11982
447217003747	RHS Repeat; Region: RHS_repeat; cl11982
447217003748	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217003749	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
447217003750	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
447217003751	dimerization interface [polypeptide binding]; other site
447217003752	DNA binding residues [nucleotide binding]
447217003753	Integrase core domain; Region: rve; pfam00665
447217003754	transposase/IS protein; Provisional; Region: PRK09183
447217003755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003756	Walker A motif; other site
447217003757	ATP binding site [chemical binding]; other site
447217003758	Walker B motif; other site
447217003759	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
447217003760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217003761	ATP binding site [chemical binding]; other site
447217003762	putative Mg++ binding site [ion binding]; other site
447217003763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217003764	nucleotide binding region [chemical binding]; other site
447217003765	ATP-binding site [chemical binding]; other site
447217003766	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217003767	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217003768	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217003769	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217003770	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217003771	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217003772	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
447217003773	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
447217003774	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
447217003775	dimerization interface [polypeptide binding]; other site
447217003776	DPS ferroxidase diiron center [ion binding]; other site
447217003777	ion pore; other site
447217003778	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
447217003779	thiS-thiF/thiG interaction site; other site
447217003780	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
447217003781	ThiS interaction site; other site
447217003782	putative active site [active]
447217003783	tetramer interface [polypeptide binding]; other site
447217003784	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
447217003785	active site
447217003786	thiamine phosphate binding site [chemical binding]; other site
447217003787	pyrophosphate binding site [ion binding]; other site
447217003788	FtsJ-like methyltransferase; Region: FtsJ; cl17430
447217003789	Methyltransferase domain; Region: Methyltransf_31; pfam13847
447217003790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217003791	S-adenosylmethionine binding site [chemical binding]; other site
447217003792	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
447217003793	active site
447217003794	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
447217003795	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217003796	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217003797	active site
447217003798	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
447217003799	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
447217003800	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
447217003801	putative active site; other site
447217003802	catalytic residue [active]
447217003803	Protein of unknown function (DUF507); Region: DUF507; pfam04368
447217003804	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217003805	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217003806	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217003807	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
447217003808	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217003809	catalytic residue [active]
447217003810	Maf-like protein; Region: Maf; pfam02545
447217003811	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
447217003812	active site
447217003813	dimer interface [polypeptide binding]; other site
447217003814	SurA N-terminal domain; Region: SurA_N_3; cl07813
447217003815	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
447217003816	rod shape-determining protein MreC; Provisional; Region: PRK13922
447217003817	rod shape-determining protein MreC; Region: MreC; pfam04085
447217003818	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
447217003819	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
447217003820	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
447217003821	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
447217003822	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217003823	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217003824	catalytic residues [active]
447217003825	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217003826	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
447217003827	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
447217003828	tRNA; other site
447217003829	putative tRNA binding site [nucleotide binding]; other site
447217003830	putative NADP binding site [chemical binding]; other site
447217003831	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
447217003832	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
447217003833	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
447217003834	domain interfaces; other site
447217003835	active site
447217003836	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
447217003837	active site
447217003838	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
447217003839	Uncharacterized conserved protein [Function unknown]; Region: COG0585
447217003840	Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577
447217003841	active site
447217003842	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
447217003843	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
447217003844	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
447217003845	active site
447217003846	PHP-associated; Region: PHP_C; pfam13263
447217003847	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217003848	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217003849	active site
447217003850	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
447217003851	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
447217003852	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
447217003853	active site
447217003854	effector binding site; other site
447217003855	dimer interface [polypeptide binding]; other site
447217003856	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217003857	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217003858	putative dimer interface [polypeptide binding]; other site
447217003859	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
447217003860	pyrroline-5-carboxylate reductase; Region: PLN02688
447217003861	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
447217003862	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
447217003863	hydroxyglutarate oxidase; Provisional; Region: PRK11728
447217003864	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217003865	catalytic loop [active]
447217003866	iron binding site [ion binding]; other site
447217003867	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
447217003868	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
447217003869	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217003870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003871	NAD(P) binding site [chemical binding]; other site
447217003872	active site
447217003873	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217003874	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
447217003875	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
447217003876	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217003877	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003878	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217003879	active site
447217003880	ATP binding site [chemical binding]; other site
447217003881	substrate binding site [chemical binding]; other site
447217003882	activation loop (A-loop); other site
447217003883	PEGA domain; Region: PEGA; pfam08308
447217003884	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
447217003885	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217003886	DNA binding residues [nucleotide binding]
447217003887	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
447217003888	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
447217003889	purine monophosphate binding site [chemical binding]; other site
447217003890	dimer interface [polypeptide binding]; other site
447217003891	putative catalytic residues [active]
447217003892	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
447217003893	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
447217003894	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
447217003895	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
447217003896	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
447217003897	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
447217003898	AIR carboxylase; Region: AIRC; pfam00731
447217003899	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
447217003900	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
447217003901	Predicted permeases [General function prediction only]; Region: COG0795
447217003902	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
447217003903	O-Antigen ligase; Region: Wzy_C; cl04850
447217003904	ABC-2 type transporter; Region: ABC2_membrane; cl17235
447217003905	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
447217003906	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
447217003907	Walker A/P-loop; other site
447217003908	ATP binding site [chemical binding]; other site
447217003909	Q-loop/lid; other site
447217003910	ABC transporter signature motif; other site
447217003911	Walker B; other site
447217003912	D-loop; other site
447217003913	H-loop/switch region; other site
447217003914	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
447217003915	putative homodimer interface [polypeptide binding]; other site
447217003916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217003917	active site
447217003918	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217003919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217003920	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
447217003921	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
447217003922	DXD motif; other site
447217003923	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
447217003924	Bacterial sugar transferase; Region: Bac_transf; pfam02397
447217003925	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
447217003926	Uncharacterized conserved protein [Function unknown]; Region: COG4198
447217003927	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
447217003928	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
447217003929	dimer interface [polypeptide binding]; other site
447217003930	active site
447217003931	Schiff base residues; other site
447217003932	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
447217003933	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217003934	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
447217003935	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
447217003936	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217003937	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
447217003938	homodimer interface [polypeptide binding]; other site
447217003939	homotetramer interface [polypeptide binding]; other site
447217003940	active site pocket [active]
447217003941	cleavage site
447217003942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217003943	binding surface
447217003944	TPR motif; other site
447217003945	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217003946	PemK-like protein; Region: PemK; pfam02452
447217003947	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217003948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003949	active site
447217003950	phosphorylation site [posttranslational modification]
447217003951	intermolecular recognition site; other site
447217003952	dimerization interface [polypeptide binding]; other site
447217003953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217003954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
447217003955	dimerization interface [polypeptide binding]; other site
447217003956	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
447217003957	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
447217003958	TPP-binding site [chemical binding]; other site
447217003959	tetramer interface [polypeptide binding]; other site
447217003960	heterodimer interface [polypeptide binding]; other site
447217003961	phosphorylation loop region [posttranslational modification]
447217003962	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
447217003963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
447217003964	DNA binding residues [nucleotide binding]
447217003965	Methyltransferase domain; Region: Methyltransf_11; pfam08241
447217003966	Radical SAM superfamily; Region: Radical_SAM; pfam04055
447217003967	oxidative damage protection protein; Provisional; Region: PRK05408
447217003968	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217003969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003970	non-specific DNA binding site [nucleotide binding]; other site
447217003971	salt bridge; other site
447217003972	sequence-specific DNA binding site [nucleotide binding]; other site
447217003973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
447217003974	phosphorylation site [posttranslational modification]
447217003975	intermolecular recognition site; other site
447217003976	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
447217003977	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
447217003978	dimer interface [polypeptide binding]; other site
447217003979	putative functional site; other site
447217003980	putative MPT binding site; other site
447217003981	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
447217003982	ribonuclease R; Region: RNase_R; TIGR02063
447217003983	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
447217003984	RNB domain; Region: RNB; pfam00773
447217003985	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
447217003986	RNA binding site [nucleotide binding]; other site
447217003987	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
447217003988	FOG: CBS domain [General function prediction only]; Region: COG0517
447217003989	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
447217003990	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217003991	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
447217003992	Walker A/P-loop; other site
447217003993	ATP binding site [chemical binding]; other site
447217003994	Q-loop/lid; other site
447217003995	ABC transporter signature motif; other site
447217003996	Walker B; other site
447217003997	D-loop; other site
447217003998	H-loop/switch region; other site
447217003999	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217004000	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
447217004001	Walker A/P-loop; other site
447217004002	ATP binding site [chemical binding]; other site
447217004003	Q-loop/lid; other site
447217004004	ABC transporter signature motif; other site
447217004005	Walker B; other site
447217004006	D-loop; other site
447217004007	H-loop/switch region; other site
447217004008	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
447217004009	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217004010	TM-ABC transporter signature motif; other site
447217004011	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217004012	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
447217004013	TM-ABC transporter signature motif; other site
447217004014	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
447217004015	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
447217004016	MutS domain III; Region: MutS_III; pfam05192
447217004017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217004018	Walker A/P-loop; other site
447217004019	ATP binding site [chemical binding]; other site
447217004020	Q-loop/lid; other site
447217004021	ABC transporter signature motif; other site
447217004022	Walker B; other site
447217004023	D-loop; other site
447217004024	H-loop/switch region; other site
447217004025	Smr domain; Region: Smr; pfam01713
447217004026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217004027	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217004028	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
447217004029	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
447217004030	NodB motif; other site
447217004031	putative active site [active]
447217004032	putative catalytic site [active]
447217004033	putative Zn binding site [ion binding]; other site
447217004034	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
447217004035	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
447217004036	DNA binding residues [nucleotide binding]
447217004037	Caspase domain; Region: Peptidase_C14; pfam00656
447217004038	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
447217004039	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
447217004040	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
447217004041	active site
447217004042	(T/H)XGH motif; other site
447217004043	Rossmann-like domain; Region: Rossmann-like; pfam10727
447217004044	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
447217004045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004046	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217004047	Walker A motif; other site
447217004048	ATP binding site [chemical binding]; other site
447217004049	Walker B motif; other site
447217004050	arginine finger; other site
447217004051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004052	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217004053	Walker A motif; other site
447217004054	ATP binding site [chemical binding]; other site
447217004055	Walker B motif; other site
447217004056	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
447217004057	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
447217004058	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217004059	4Fe-4S binding domain; Region: Fer4_6; pfam12837
447217004060	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
447217004061	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217004062	iron-sulfur cluster [ion binding]; other site
447217004063	[2Fe-2S] cluster binding site [ion binding]; other site
447217004064	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217004065	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
447217004066	interchain domain interface [polypeptide binding]; other site
447217004067	intrachain domain interface; other site
447217004068	heme bL binding site [chemical binding]; other site
447217004069	heme bH binding site [chemical binding]; other site
447217004070	Qo binding site; other site
447217004071	intrachain domain interface; other site
447217004072	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
447217004073	Qo binding site; other site
447217004074	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
447217004075	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
447217004076	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
447217004077	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
447217004078	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
447217004079	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
447217004080	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217004081	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217004082	Walker A/P-loop; other site
447217004083	ATP binding site [chemical binding]; other site
447217004084	Q-loop/lid; other site
447217004085	ABC transporter signature motif; other site
447217004086	Walker B; other site
447217004087	D-loop; other site
447217004088	H-loop/switch region; other site
447217004089	NosL; Region: NosL; cl01769
447217004090	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
447217004091	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217004092	active site
447217004093	nucleophile elbow; other site
447217004094	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217004095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217004096	active site
447217004097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004098	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217004099	TPR motif; other site
447217004100	binding surface
447217004101	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
447217004102	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
447217004103	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
447217004104	ring oligomerisation interface [polypeptide binding]; other site
447217004105	ATP/Mg binding site [chemical binding]; other site
447217004106	stacking interactions; other site
447217004107	hinge regions; other site
447217004108	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004110	active site
447217004111	phosphorylation site [posttranslational modification]
447217004112	intermolecular recognition site; other site
447217004113	dimerization interface [polypeptide binding]; other site
447217004114	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217004115	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217004116	metal binding site [ion binding]; metal-binding site
447217004117	active site
447217004118	I-site; other site
447217004119	CheW-like domain; Region: CheW; pfam01584
447217004120	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004122	active site
447217004123	phosphorylation site [posttranslational modification]
447217004124	intermolecular recognition site; other site
447217004125	dimerization interface [polypeptide binding]; other site
447217004126	valyl-tRNA synthetase; Provisional; Region: valS; PRK14900
447217004127	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
447217004128	HIGH motif; other site
447217004129	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
447217004130	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
447217004131	active site
447217004132	KMSKS motif; other site
447217004133	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
447217004134	tRNA binding surface [nucleotide binding]; other site
447217004135	anticodon binding site; other site
447217004136	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
447217004137	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
447217004138	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
447217004139	dimerization interface [polypeptide binding]; other site
447217004140	active site
447217004141	Biotin operon repressor [Transcription]; Region: BirA; COG1654
447217004142	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
447217004143	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
447217004144	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
447217004145	pantothenate kinase; Reviewed; Region: PRK13321
447217004146	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
447217004147	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
447217004148	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
447217004149	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
447217004150	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004152	active site
447217004153	phosphorylation site [posttranslational modification]
447217004154	intermolecular recognition site; other site
447217004155	dimerization interface [polypeptide binding]; other site
447217004156	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217004157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217004158	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217004159	DNA binding residues [nucleotide binding]
447217004160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217004161	Radical SAM superfamily; Region: Radical_SAM; pfam04055
447217004162	FeS/SAM binding site; other site
447217004163	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
447217004164	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
447217004165	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
447217004166	putative RNA binding site [nucleotide binding]; other site
447217004167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217004168	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
447217004169	Flavoprotein; Region: Flavoprotein; pfam02441
447217004170	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
447217004171	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
447217004172	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
447217004173	Fe-S cluster binding site [ion binding]; other site
447217004174	active site
447217004175	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
447217004176	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
447217004177	active site residues [active]
447217004178	dimer interface [polypeptide binding]; other site
447217004179	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
447217004180	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
447217004181	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
447217004182	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
447217004183	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
447217004184	catalytic nucleophile [active]
447217004185	putative acyltransferase; Provisional; Region: PRK05790
447217004186	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217004187	dimer interface [polypeptide binding]; other site
447217004188	active site
447217004189	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
447217004190	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
447217004191	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
447217004192	PilZ domain; Region: PilZ; cl01260
447217004193	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
447217004194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217004195	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217004196	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217004197	acyl-activating enzyme (AAE) consensus motif; other site
447217004198	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217004199	AMP binding site [chemical binding]; other site
447217004200	active site
447217004201	CoA binding site [chemical binding]; other site
447217004202	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
447217004203	Cna protein B-type domain; Region: Cna_B_2; pfam13715
447217004204	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
447217004205	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
447217004206	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
447217004207	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
447217004208	Peptidase family M48; Region: Peptidase_M48; pfam01435
447217004209	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
447217004210	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
447217004211	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
447217004212	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
447217004213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217004214	FeS/SAM binding site; other site
447217004215	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
447217004216	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
447217004217	trimer interface [polypeptide binding]; other site
447217004218	putative metal binding site [ion binding]; other site
447217004219	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
447217004220	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217004221	ligand binding site [chemical binding]; other site
447217004222	flexible hinge region; other site
447217004223	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217004224	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217004225	PilZ domain; Region: PilZ; cl01260
447217004226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217004227	rod shape-determining protein MreB; Provisional; Region: PRK13930
447217004228	nucleotide binding site [chemical binding]; other site
447217004229	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
447217004230	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
447217004231	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
447217004232	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
447217004233	active site
447217004234	GMP synthase; Reviewed; Region: guaA; PRK00074
447217004235	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
447217004236	AMP/PPi binding site [chemical binding]; other site
447217004237	candidate oxyanion hole; other site
447217004238	catalytic triad [active]
447217004239	potential glutamine specificity residues [chemical binding]; other site
447217004240	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
447217004241	ATP Binding subdomain [chemical binding]; other site
447217004242	Ligand Binding sites [chemical binding]; other site
447217004243	Dimerization subdomain; other site
447217004244	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
447217004245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217004246	TPR motif; other site
447217004247	binding surface
447217004248	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217004249	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
447217004250	acyl-activating enzyme (AAE) consensus motif; other site
447217004251	putative AMP binding site [chemical binding]; other site
447217004252	putative active site [active]
447217004253	putative CoA binding site [chemical binding]; other site
447217004254	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004256	active site
447217004257	phosphorylation site [posttranslational modification]
447217004258	intermolecular recognition site; other site
447217004259	dimerization interface [polypeptide binding]; other site
447217004260	SCP-2 sterol transfer family; Region: SCP2; pfam02036
447217004261	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
447217004262	CoA-transferase family III; Region: CoA_transf_3; pfam02515
447217004263	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
447217004264	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217004265	intersubunit interface [polypeptide binding]; other site
447217004266	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
447217004267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217004268	Walker A/P-loop; other site
447217004269	ATP binding site [chemical binding]; other site
447217004270	Q-loop/lid; other site
447217004271	ABC transporter signature motif; other site
447217004272	Walker B; other site
447217004273	D-loop; other site
447217004274	H-loop/switch region; other site
447217004275	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
447217004276	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
447217004277	dimer interface [polypeptide binding]; other site
447217004278	ABC-ATPase subunit  interface; other site
447217004279	HsdM N-terminal domain; Region: HsdM_N; pfam12161
447217004280	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
447217004281	Methyltransferase domain; Region: Methyltransf_26; pfam13659
447217004282	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
447217004283	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
447217004284	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
447217004285	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
447217004286	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
447217004287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217004288	ATP binding site [chemical binding]; other site
447217004289	putative Mg++ binding site [ion binding]; other site
447217004290	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
447217004291	Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653
447217004292	SEC-C motif; Region: SEC-C; pfam02810
447217004293	Domain of unknown function (DUF932); Region: DUF932; cl12129
447217004294	Domain of unknown function (DUF932); Region: DUF932; cl12129
447217004295	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
447217004296	Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909
447217004297	metal binding triad [ion binding]; metal-binding site
447217004298	Protein of unknown function (DUF554); Region: DUF554; pfam04474
447217004299	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
447217004300	DNA-binding interface [nucleotide binding]; DNA binding site
447217004301	Winged helix-turn helix; Region: HTH_29; pfam13551
447217004302	HTH-like domain; Region: HTH_21; pfam13276
447217004303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
447217004304	Integrase core domain; Region: rve; pfam00665
447217004305	Integrase core domain; Region: rve_3; pfam13683
447217004306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217004307	Helix-turn-helix domain; Region: HTH_18; pfam12833
447217004308	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217004309	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004310	NAD(P) binding site [chemical binding]; other site
447217004311	active site
447217004312	Predicted permease [General function prediction only]; Region: COG2985
447217004313	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
447217004314	TrkA-C domain; Region: TrkA_C; pfam02080
447217004315	TrkA-C domain; Region: TrkA_C; pfam02080
447217004316	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
447217004317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217004318	TPR repeat; Region: TPR_11; pfam13414
447217004319	binding surface
447217004320	TPR motif; other site
447217004321	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
447217004322	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
447217004323	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004324	active site
447217004325	Methyltransferase domain; Region: Methyltransf_23; pfam13489
447217004326	Methyltransferase domain; Region: Methyltransf_12; pfam08242
447217004327	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217004328	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217004329	dimer interface [polypeptide binding]; other site
447217004330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004331	catalytic residue [active]
447217004332	aspartate aminotransferase; Provisional; Region: PRK06836
447217004333	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217004334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004335	homodimer interface [polypeptide binding]; other site
447217004336	catalytic residue [active]
447217004337	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217004338	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
447217004339	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217004340	Moco binding site; other site
447217004341	metal coordination site [ion binding]; other site
447217004342	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
447217004343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004344	NAD(P) binding site [chemical binding]; other site
447217004345	active site
447217004346	ribonuclease Z; Reviewed; Region: PRK00055
447217004347	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217004348	lipoyl attachment site [posttranslational modification]; other site
447217004349	short chain dehydrogenase; Provisional; Region: PRK08267
447217004350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004351	NAD(P) binding site [chemical binding]; other site
447217004352	active site
447217004353	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
447217004354	NAD(P) binding pocket [chemical binding]; other site
447217004355	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
447217004356	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004357	molybdopterin cofactor binding site; other site
447217004358	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004359	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
447217004360	putative molybdopterin cofactor binding site; other site
447217004361	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
447217004362	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217004363	putative NAD(P) binding site [chemical binding]; other site
447217004364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217004365	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
447217004366	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
447217004367	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
447217004368	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
447217004369	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217004370	active site
447217004371	metal binding site [ion binding]; metal-binding site
447217004372	DNA binding site [nucleotide binding]
447217004373	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217004374	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
447217004375	Beta-lactamase; Region: Beta-lactamase; pfam00144
447217004376	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
447217004377	putative hydrophobic ligand binding site [chemical binding]; other site
447217004378	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217004379	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217004380	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004381	putative effector binding pocket; other site
447217004382	dimerization interface [polypeptide binding]; other site
447217004383	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
447217004384	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
447217004385	elongation factor G; Reviewed; Region: PRK12740
447217004386	G1 box; other site
447217004387	putative GEF interaction site [polypeptide binding]; other site
447217004388	GTP/Mg2+ binding site [chemical binding]; other site
447217004389	Switch I region; other site
447217004390	G2 box; other site
447217004391	G3 box; other site
447217004392	Switch II region; other site
447217004393	G4 box; other site
447217004394	G5 box; other site
447217004395	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
447217004396	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217004397	Elongation factor G C-terminus; Region: EFG_C; smart00838
447217004398	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
447217004399	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217004400	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
447217004401	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
447217004402	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
447217004403	Moco binding site; other site
447217004404	metal coordination site [ion binding]; other site
447217004405	dimerization interface [polypeptide binding]; other site
447217004406	Cytochrome c; Region: Cytochrom_C; pfam00034
447217004407	Cytochrome c; Region: Cytochrom_C; cl11414
447217004408	Predicted secreted protein [Function unknown]; Region: COG5501
447217004409	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
447217004410	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
447217004411	DsrE/DsrF-like family; Region: DrsE; cl00672
447217004412	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
447217004413	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
447217004414	active site
447217004415	metal binding site [ion binding]; metal-binding site
447217004416	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
447217004417	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
447217004418	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
447217004419	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
447217004420	Cu(I) binding site [ion binding]; other site
447217004421	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
447217004422	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
447217004423	Cytochrome c; Region: Cytochrom_C; pfam00034
447217004424	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
447217004425	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
447217004426	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
447217004427	Subunit I/III interface [polypeptide binding]; other site
447217004428	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
447217004429	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
447217004430	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
447217004431	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
447217004432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004433	S-adenosylmethionine binding site [chemical binding]; other site
447217004434	Cupin; Region: Cupin_6; pfam12852
447217004435	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
447217004436	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217004437	OsmC-like protein; Region: OsmC; pfam02566
447217004438	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
447217004439	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217004440	tetramer interface [polypeptide binding]; other site
447217004441	active site
447217004442	Mg2+/Mn2+ binding site [ion binding]; other site
447217004443	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
447217004444	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
447217004445	TrkA-C domain; Region: TrkA_C; pfam02080
447217004446	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
447217004447	nucleotide binding site [chemical binding]; other site
447217004448	putative NEF/HSP70 interaction site [polypeptide binding]; other site
447217004449	SBD interface [polypeptide binding]; other site
447217004450	Transposase domain (DUF772); Region: DUF772; pfam05598
447217004451	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217004452	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217004453	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
447217004454	4Fe-4S binding domain; Region: Fer4; pfam00037
447217004455	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
447217004456	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
447217004457	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
447217004458	Predicted integral membrane protein [Function unknown]; Region: COG0392
447217004459	Uncharacterized conserved protein [Function unknown]; Region: COG2898
447217004460	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
447217004461	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
447217004462	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217004463	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
447217004464	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
447217004465	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217004466	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217004467	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217004468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217004469	DNA binding residues [nucleotide binding]
447217004470	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
447217004471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
447217004472	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
447217004473	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
447217004474	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
447217004475	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
447217004476	tetrameric interface [polypeptide binding]; other site
447217004477	NAD binding site [chemical binding]; other site
447217004478	catalytic residues [active]
447217004479	Predicted membrane protein [Function unknown]; Region: COG2259
447217004480	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
447217004481	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
447217004482	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217004483	dimerization interface [polypeptide binding]; other site
447217004484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004485	dimer interface [polypeptide binding]; other site
447217004486	phosphorylation site [posttranslational modification]
447217004487	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
447217004488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004489	ATP binding site [chemical binding]; other site
447217004490	Mg2+ binding site [ion binding]; other site
447217004491	G-X-G motif; other site
447217004492	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004494	active site
447217004495	phosphorylation site [posttranslational modification]
447217004496	intermolecular recognition site; other site
447217004497	dimerization interface [polypeptide binding]; other site
447217004498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004499	Walker A motif; other site
447217004500	ATP binding site [chemical binding]; other site
447217004501	Walker B motif; other site
447217004502	arginine finger; other site
447217004503	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217004504	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217004505	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217004506	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217004507	multidrug efflux protein; Reviewed; Region: PRK09579
447217004508	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
447217004509	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
447217004510	DNA-binding site [nucleotide binding]; DNA binding site
447217004511	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217004512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004513	homodimer interface [polypeptide binding]; other site
447217004514	catalytic residue [active]
447217004515	Transcriptional activator [Transcription]; Region: ChrR; COG3806
447217004516	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
447217004517	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004518	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217004519	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004520	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004521	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
447217004522	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004523	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004524	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
447217004525	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
447217004526	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
447217004527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004528	S-adenosylmethionine binding site [chemical binding]; other site
447217004529	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
447217004530	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
447217004531	malate dehydrogenase; Reviewed; Region: PRK06223
447217004532	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
447217004533	NAD(P) binding site [chemical binding]; other site
447217004534	dimer interface [polypeptide binding]; other site
447217004535	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217004536	substrate binding site [chemical binding]; other site
447217004537	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
447217004538	BNR repeat-like domain; Region: BNR_2; pfam13088
447217004539	Ubiquitin-like proteins; Region: UBQ; cl00155
447217004540	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217004541	tetramer interface [polypeptide binding]; other site
447217004542	active site
447217004543	Mg2+/Mn2+ binding site [ion binding]; other site
447217004544	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
447217004545	5'-3' exonuclease; Region: 53EXOc; smart00475
447217004546	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
447217004547	active site
447217004548	metal binding site 1 [ion binding]; metal-binding site
447217004549	putative 5' ssDNA interaction site; other site
447217004550	metal binding site 3; metal-binding site
447217004551	metal binding site 2 [ion binding]; metal-binding site
447217004552	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
447217004553	putative DNA binding site [nucleotide binding]; other site
447217004554	putative metal binding site [ion binding]; other site
447217004555	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
447217004556	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
447217004557	Nitrogen regulatory protein P-II; Region: P-II; smart00938
447217004558	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
447217004559	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217004560	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
447217004561	putative FMN binding site [chemical binding]; other site
447217004562	LysR family transcriptional regulator; Provisional; Region: PRK14997
447217004563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217004564	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004565	putative effector binding pocket; other site
447217004566	dimerization interface [polypeptide binding]; other site
447217004567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217004568	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
447217004569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217004570	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
447217004571	dimerization interface [polypeptide binding]; other site
447217004572	substrate binding pocket [chemical binding]; other site
447217004573	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
447217004574	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
447217004575	active site 1 [active]
447217004576	dimer interface [polypeptide binding]; other site
447217004577	hexamer interface [polypeptide binding]; other site
447217004578	active site 2 [active]
447217004579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217004580	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004581	dimerization interface [polypeptide binding]; other site
447217004582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004583	dimer interface [polypeptide binding]; other site
447217004584	phosphorylation site [posttranslational modification]
447217004585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004586	ATP binding site [chemical binding]; other site
447217004587	Mg2+ binding site [ion binding]; other site
447217004588	G-X-G motif; other site
447217004589	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004591	active site
447217004592	phosphorylation site [posttranslational modification]
447217004593	intermolecular recognition site; other site
447217004594	dimerization interface [polypeptide binding]; other site
447217004595	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
447217004596	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
447217004597	putative glycosyltransferase, TIGR04348 family; Region: TIGR04348
447217004598	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217004599	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
447217004600	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
447217004601	mercuric reductase; Validated; Region: PRK06370
447217004602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217004603	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217004604	Pirin-related protein [General function prediction only]; Region: COG1741
447217004605	Pirin; Region: Pirin; pfam02678
447217004606	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
447217004607	EamA-like transporter family; Region: EamA; pfam00892
447217004608	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004609	dimerization interface [polypeptide binding]; other site
447217004610	putative effector binding pocket; other site
447217004611	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217004612	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217004613	catalytic residues [active]
447217004614	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217004615	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004616	putative active site [active]
447217004617	heme pocket [chemical binding]; other site
447217004618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004619	dimer interface [polypeptide binding]; other site
447217004620	phosphorylation site [posttranslational modification]
447217004621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004622	ATP binding site [chemical binding]; other site
447217004623	Mg2+ binding site [ion binding]; other site
447217004624	G-X-G motif; other site
447217004625	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004627	active site
447217004628	phosphorylation site [posttranslational modification]
447217004629	intermolecular recognition site; other site
447217004630	dimerization interface [polypeptide binding]; other site
447217004631	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
447217004632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004634	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
447217004635	active site
447217004636	FOG: CBS domain [General function prediction only]; Region: COG0517
447217004637	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
447217004638	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217004639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217004640	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
447217004641	putative dimerization interface [polypeptide binding]; other site
447217004642	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
447217004643	ATP binding site [chemical binding]; other site
447217004644	ResB-like family; Region: ResB; pfam05140
447217004645	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217004646	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
447217004647	Rubrerythrin [Energy production and conversion]; Region: COG1592
447217004648	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217004649	binuclear metal center [ion binding]; other site
447217004650	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
447217004651	iron binding site [ion binding]; other site
447217004652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004653	PAS fold; Region: PAS_3; pfam08447
447217004654	putative active site [active]
447217004655	heme pocket [chemical binding]; other site
447217004656	PAS fold; Region: PAS_3; pfam08447
447217004657	GAF domain; Region: GAF; pfam01590
447217004658	GAF domain; Region: GAF_2; pfam13185
447217004659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217004660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004661	dimer interface [polypeptide binding]; other site
447217004662	phosphorylation site [posttranslational modification]
447217004663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004664	ATP binding site [chemical binding]; other site
447217004665	Mg2+ binding site [ion binding]; other site
447217004666	G-X-G motif; other site
447217004667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004668	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004669	active site
447217004670	phosphorylation site [posttranslational modification]
447217004671	intermolecular recognition site; other site
447217004672	dimerization interface [polypeptide binding]; other site
447217004673	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217004674	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217004675	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217004676	DNA binding residues [nucleotide binding]
447217004677	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217004678	active site 2 [active]
447217004679	active site 1 [active]
447217004680	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
447217004681	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004682	dimerization interface [polypeptide binding]; other site
447217004683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217004684	dimer interface [polypeptide binding]; other site
447217004685	putative CheW interface [polypeptide binding]; other site
447217004686	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
447217004687	Nitrogen fixation protein NifW; Region: NifW; cl03935
447217004688	hypothetical protein; Provisional; Region: PRK12378
447217004689	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217004690	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
447217004691	Walker A/P-loop; other site
447217004692	ATP binding site [chemical binding]; other site
447217004693	Q-loop/lid; other site
447217004694	ABC transporter signature motif; other site
447217004695	Walker B; other site
447217004696	D-loop; other site
447217004697	H-loop/switch region; other site
447217004698	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
447217004699	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217004700	TM-ABC transporter signature motif; other site
447217004701	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217004702	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
447217004703	Walker A/P-loop; other site
447217004704	ATP binding site [chemical binding]; other site
447217004705	Q-loop/lid; other site
447217004706	ABC transporter signature motif; other site
447217004707	Walker B; other site
447217004708	D-loop; other site
447217004709	H-loop/switch region; other site
447217004710	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
447217004711	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217004712	TM-ABC transporter signature motif; other site
447217004713	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
447217004714	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
447217004715	putative ligand binding site [chemical binding]; other site
447217004716	PilZ domain; Region: PilZ; pfam07238
447217004717	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
447217004718	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
447217004719	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
447217004720	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
447217004721	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
447217004722	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
447217004723	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
447217004724	[4Fe-4S] binding site [ion binding]; other site
447217004725	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004726	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004727	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004728	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
447217004729	molybdopterin cofactor binding site; other site
447217004730	PAS domain S-box; Region: sensory_box; TIGR00229
447217004731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004732	putative active site [active]
447217004733	heme pocket [chemical binding]; other site
447217004734	Hemerythrin-like domain; Region: Hr-like; cd12108
447217004735	Fe binding site [ion binding]; other site
447217004736	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
447217004737	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217004738	putative acyl-acceptor binding pocket; other site
447217004739	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217004740	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
447217004741	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
447217004742	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
447217004743	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217004744	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
447217004745	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
447217004746	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
447217004747	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
447217004748	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
447217004749	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
447217004750	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217004751	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217004752	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217004753	ABC transporter; Region: ABC_tran_2; pfam12848
447217004754	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217004755	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
447217004756	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
447217004757	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217004758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217004759	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
447217004760	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
447217004761	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004763	active site
447217004764	phosphorylation site [posttranslational modification]
447217004765	intermolecular recognition site; other site
447217004766	dimerization interface [polypeptide binding]; other site
447217004767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004768	Walker A motif; other site
447217004769	ATP binding site [chemical binding]; other site
447217004770	Walker B motif; other site
447217004771	arginine finger; other site
447217004772	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217004773	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217004774	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217004775	substrate binding pocket [chemical binding]; other site
447217004776	membrane-bound complex binding site; other site
447217004777	hinge residues; other site
447217004778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004779	dimer interface [polypeptide binding]; other site
447217004780	phosphorylation site [posttranslational modification]
447217004781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004782	ATP binding site [chemical binding]; other site
447217004783	Mg2+ binding site [ion binding]; other site
447217004784	G-X-G motif; other site
447217004785	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
447217004786	putative deacylase active site [active]
447217004787	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
447217004788	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217004789	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217004790	catalytic residues [active]
447217004791	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
447217004792	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217004793	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
447217004794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217004795	Asparaginase; Region: Asparaginase; pfam00710
447217004796	active site
447217004797	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
447217004798	Hemerythrin-like domain; Region: Hr-like; cd12108
447217004799	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
447217004800	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
447217004801	Hemerythrin-like domain; Region: Hr-like; cd12108
447217004802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004803	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217004804	Walker A motif; other site
447217004805	ATP binding site [chemical binding]; other site
447217004806	Walker B motif; other site
447217004807	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217004808	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
447217004809	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217004810	E3 interaction surface; other site
447217004811	lipoyl attachment site [posttranslational modification]; other site
447217004812	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217004813	E3 interaction surface; other site
447217004814	lipoyl attachment site [posttranslational modification]; other site
447217004815	e3 binding domain; Region: E3_binding; pfam02817
447217004816	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
447217004817	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
447217004818	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
447217004819	dimer interface [polypeptide binding]; other site
447217004820	TPP-binding site [chemical binding]; other site
447217004821	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
447217004822	Kelch motif; Region: Kelch_1; pfam01344
447217004823	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217004824	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217004825	active site
447217004826	ATP binding site [chemical binding]; other site
447217004827	substrate binding site [chemical binding]; other site
447217004828	activation loop (A-loop); other site
447217004829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004830	TPR motif; other site
447217004831	binding surface
447217004832	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217004833	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
447217004834	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217004835	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217004836	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217004837	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217004838	active site
447217004839	catalytic tetrad [active]
447217004840	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217004841	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
447217004842	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217004843	active site
447217004844	metal binding site [ion binding]; metal-binding site
447217004845	Putative exonuclease, RdgC; Region: RdgC; cl01122
447217004846	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217004847	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217004848	active site
447217004849	Winged helix-turn helix; Region: HTH_29; pfam13551
447217004850	Homeodomain-like domain; Region: HTH_23; cl17451
447217004851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
447217004852	Integrase core domain; Region: rve; pfam00665
447217004853	Integrase core domain; Region: rve_3; pfam13683
447217004854	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
447217004855	G1 box; other site
447217004856	GTP/Mg2+ binding site [chemical binding]; other site
447217004857	G2 box; other site
447217004858	Switch I region; other site
447217004859	G3 box; other site
447217004860	Switch II region; other site
447217004861	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
447217004862	G4 box; other site
447217004863	G5 box; other site
447217004864	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
447217004865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217004866	Coenzyme A binding pocket [chemical binding]; other site
447217004867	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
447217004868	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
447217004869	G1 box; other site
447217004870	putative GEF interaction site [polypeptide binding]; other site
447217004871	GTP/Mg2+ binding site [chemical binding]; other site
447217004872	Switch I region; other site
447217004873	G2 box; other site
447217004874	G3 box; other site
447217004875	Switch II region; other site
447217004876	G4 box; other site
447217004877	G5 box; other site
447217004878	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
447217004879	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217004880	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
447217004881	dimer interface [polypeptide binding]; other site
447217004882	active site
447217004883	metal binding site [ion binding]; metal-binding site
447217004884	glutathione binding site [chemical binding]; other site
447217004885	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
447217004886	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
447217004887	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
447217004888	hexamer interface [polypeptide binding]; other site
447217004889	ligand binding site [chemical binding]; other site
447217004890	putative active site [active]
447217004891	NAD(P) binding site [chemical binding]; other site
447217004892	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
447217004893	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
447217004894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004895	S-adenosylmethionine binding site [chemical binding]; other site
447217004896	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
447217004897	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
447217004898	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217004899	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217004900	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217004901	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217004902	substrate binding pocket [chemical binding]; other site
447217004903	membrane-bound complex binding site; other site
447217004904	hinge residues; other site
447217004905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004906	ATP binding site [chemical binding]; other site
447217004907	Mg2+ binding site [ion binding]; other site
447217004908	G-X-G motif; other site
447217004909	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004911	active site
447217004912	phosphorylation site [posttranslational modification]
447217004913	intermolecular recognition site; other site
447217004914	dimerization interface [polypeptide binding]; other site
447217004915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004916	Walker A motif; other site
447217004917	ATP binding site [chemical binding]; other site
447217004918	Walker B motif; other site
447217004919	arginine finger; other site
447217004920	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217004921	Transposase domain (DUF772); Region: DUF772; pfam05598
447217004922	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217004923	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217004924	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
447217004925	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
447217004926	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217004927	active site
447217004928	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
447217004929	L-aspartate oxidase; Provisional; Region: PRK06175
447217004930	Predicted oxidoreductase [General function prediction only]; Region: COG3573
447217004931	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
447217004932	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
447217004933	NAD(P) binding site [chemical binding]; other site
447217004934	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
447217004935	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
447217004936	substrate-cofactor binding pocket; other site
447217004937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004938	catalytic residue [active]
447217004939	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217004940	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
447217004941	ATP binding site [chemical binding]; other site
447217004942	putative Mg++ binding site [ion binding]; other site
447217004943	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217004944	nucleotide binding region [chemical binding]; other site
447217004945	ATP-binding site [chemical binding]; other site
447217004946	DEAD/H associated; Region: DEAD_assoc; pfam08494
447217004947	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
447217004948	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
447217004949	DNA binding site [nucleotide binding]
447217004950	catalytic residue [active]
447217004951	H2TH interface [polypeptide binding]; other site
447217004952	putative catalytic residues [active]
447217004953	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217004954	CHASE domain; Region: CHASE; pfam03924
447217004955	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004956	dimer interface [polypeptide binding]; other site
447217004957	phosphorylation site [posttranslational modification]
447217004958	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217004959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004960	ATP binding site [chemical binding]; other site
447217004961	Mg2+ binding site [ion binding]; other site
447217004962	G-X-G motif; other site
447217004963	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217004964	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004965	molybdopterin cofactor binding site; other site
447217004966	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004967	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004968	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217004969	molybdopterin cofactor binding site; other site
447217004970	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
447217004971	4Fe-4S binding domain; Region: Fer4_6; pfam12837
447217004972	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
447217004973	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
447217004974	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
447217004975	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
447217004976	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
447217004977	active site
447217004978	ADP/pyrophosphate binding site [chemical binding]; other site
447217004979	dimerization interface [polypeptide binding]; other site
447217004980	allosteric effector site; other site
447217004981	fructose-1,6-bisphosphate binding site; other site
447217004982	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
447217004983	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217004984	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217004985	catalytic residue [active]
447217004986	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217004987	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
447217004988	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
447217004989	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
447217004990	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
447217004991	metal binding site [ion binding]; metal-binding site
447217004992	dimer interface [polypeptide binding]; other site
447217004993	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217004994	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217004995	putative acyl-acceptor binding pocket; other site
447217004996	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
447217004997	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217004998	active site
447217004999	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217005000	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217005001	active site
447217005002	catalytic tetrad [active]
447217005003	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
447217005004	diiron binding motif [ion binding]; other site
447217005005	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
447217005006	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
447217005007	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
447217005008	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
447217005009	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
447217005010	active site
447217005011	catalytic residues [active]
447217005012	metal binding site [ion binding]; metal-binding site
447217005013	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
447217005014	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
447217005015	tartrate dehydrogenase; Region: TTC; TIGR02089
447217005016	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
447217005017	fumarate hydratase; Provisional; Region: PRK15389
447217005018	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
447217005019	Fumarase C-terminus; Region: Fumerase_C; pfam05683
447217005020	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
447217005021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
447217005022	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
447217005023	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
447217005024	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217005025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217005026	Walker A/P-loop; other site
447217005027	ATP binding site [chemical binding]; other site
447217005028	Q-loop/lid; other site
447217005029	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217005030	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217005031	elongation factor G; Reviewed; Region: PRK12739
447217005032	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
447217005033	G1 box; other site
447217005034	GTP/Mg2+ binding site [chemical binding]; other site
447217005035	G2 box; other site
447217005036	Switch I region; other site
447217005037	G3 box; other site
447217005038	Switch II region; other site
447217005039	G4 box; other site
447217005040	G5 box; other site
447217005041	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217005042	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
447217005043	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217005044	DTW domain; Region: DTW; cl01221
447217005045	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
447217005046	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217005047	putative active site [active]
447217005048	catalytic site [active]
447217005049	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
447217005050	putative active site [active]
447217005051	catalytic site [active]
447217005052	oligoendopeptidase F; Region: pepF; TIGR00181
447217005053	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
447217005054	active site
447217005055	Zn binding site [ion binding]; other site
447217005056	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
447217005057	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
447217005058	ATP-grasp domain; Region: ATP-grasp; pfam02222
447217005059	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
447217005060	dimer interface [polypeptide binding]; other site
447217005061	substrate binding site [chemical binding]; other site
447217005062	ATP binding site [chemical binding]; other site
447217005063	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
447217005064	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
447217005065	active site
447217005066	catalytic site [active]
447217005067	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
447217005068	MarC family integral membrane protein; Region: MarC; cl00919
447217005069	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
447217005070	active site
447217005071	catalytic triad [active]
447217005072	oxyanion hole [active]
447217005073	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
447217005074	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217005075	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217005076	Walker A/P-loop; other site
447217005077	ATP binding site [chemical binding]; other site
447217005078	Q-loop/lid; other site
447217005079	ABC transporter signature motif; other site
447217005080	Walker B; other site
447217005081	D-loop; other site
447217005082	H-loop/switch region; other site
447217005083	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217005084	FtsX-like permease family; Region: FtsX; pfam02687
447217005085	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
447217005086	HDOD domain; Region: HDOD; pfam08668
447217005087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
447217005088	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
447217005089	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
447217005090	Bacterial Ig-like domain; Region: Big_5; pfam13205
447217005091	MG2 domain; Region: A2M_N; pfam01835
447217005092	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
447217005093	Alpha-2-macroglobulin family; Region: A2M; pfam00207
447217005094	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
447217005095	surface patch; other site
447217005096	thioester region; other site
447217005097	specificity defining residues; other site
447217005098	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
447217005099	Transglycosylase; Region: Transgly; pfam00912
447217005100	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
447217005101	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217005102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217005103	binding surface
447217005104	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217005105	TPR motif; other site
447217005106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217005107	TPR motif; other site
447217005108	binding surface
447217005109	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
447217005110	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
447217005111	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217005112	DXD motif; other site
447217005113	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
447217005114	phosphoglucomutase; Validated; Region: PRK07564
447217005115	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
447217005116	active site
447217005117	substrate binding site [chemical binding]; other site
447217005118	metal binding site [ion binding]; metal-binding site
447217005119	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217005120	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217005121	active site
447217005122	catalytic tetrad [active]
447217005123	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217005124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005125	NAD(P) binding site [chemical binding]; other site
447217005126	active site
447217005127	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
447217005128	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
447217005129	active site
447217005130	Zn binding site [ion binding]; other site
447217005131	CsbD-like; Region: CsbD; pfam05532
447217005132	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217005133	Protein export membrane protein; Region: SecD_SecF; cl14618
447217005134	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217005135	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217005136	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217005137	Outer membrane efflux protein; Region: OEP; pfam02321
447217005138	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
447217005139	GSH binding site [chemical binding]; other site
447217005140	catalytic residues [active]
447217005141	Peptidase family M48; Region: Peptidase_M48; cl12018
447217005142	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
447217005143	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217005144	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
447217005145	putative dimerization interface [polypeptide binding]; other site
447217005146	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
447217005147	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
447217005148	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
447217005149	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
447217005150	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
447217005151	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
447217005152	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
447217005153	putative active site [active]
447217005154	putative substrate binding site [chemical binding]; other site
447217005155	putative cosubstrate binding site; other site
447217005156	catalytic site [active]
447217005157	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005158	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217005159	dimerization interface [polypeptide binding]; other site
447217005160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005161	dimer interface [polypeptide binding]; other site
447217005162	phosphorylation site [posttranslational modification]
447217005163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005164	ATP binding site [chemical binding]; other site
447217005165	Mg2+ binding site [ion binding]; other site
447217005166	G-X-G motif; other site
447217005167	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
447217005168	active site
447217005169	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005171	active site
447217005172	phosphorylation site [posttranslational modification]
447217005173	intermolecular recognition site; other site
447217005174	dimerization interface [polypeptide binding]; other site
447217005175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005176	Walker A motif; other site
447217005177	ATP binding site [chemical binding]; other site
447217005178	Walker B motif; other site
447217005179	arginine finger; other site
447217005180	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217005181	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
447217005182	4Fe-4S binding domain; Region: Fer4; pfam00037
447217005183	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
447217005184	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217005185	lipoyl attachment site [posttranslational modification]; other site
447217005186	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
447217005187	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217005188	lipoyl attachment site [posttranslational modification]; other site
447217005189	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
447217005190	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217005191	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217005192	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217005193	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217005194	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217005195	Peptidase family M48; Region: Peptidase_M48; cl12018
447217005196	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217005197	dimerization interface [polypeptide binding]; other site
447217005198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
447217005199	Histidine kinase; Region: HisKA_3; pfam07730
447217005200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005201	ATP binding site [chemical binding]; other site
447217005202	Mg2+ binding site [ion binding]; other site
447217005203	G-X-G motif; other site
447217005204	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217005205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005206	active site
447217005207	phosphorylation site [posttranslational modification]
447217005208	intermolecular recognition site; other site
447217005209	dimerization interface [polypeptide binding]; other site
447217005210	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217005211	DNA binding residues [nucleotide binding]
447217005212	dimerization interface [polypeptide binding]; other site
447217005213	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
447217005214	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
447217005215	NAD(P) binding pocket [chemical binding]; other site
447217005216	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
447217005217	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217005218	dimerization interface [polypeptide binding]; other site
447217005219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005220	dimer interface [polypeptide binding]; other site
447217005221	phosphorylation site [posttranslational modification]
447217005222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005223	ATP binding site [chemical binding]; other site
447217005224	Mg2+ binding site [ion binding]; other site
447217005225	G-X-G motif; other site
447217005226	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005228	active site
447217005229	phosphorylation site [posttranslational modification]
447217005230	intermolecular recognition site; other site
447217005231	dimerization interface [polypeptide binding]; other site
447217005232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005233	Walker A motif; other site
447217005234	ATP binding site [chemical binding]; other site
447217005235	Walker B motif; other site
447217005236	arginine finger; other site
447217005237	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217005238	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
447217005239	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217005240	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217005241	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217005242	DNA binding residues [nucleotide binding]
447217005243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005245	dimer interface [polypeptide binding]; other site
447217005246	phosphorylation site [posttranslational modification]
447217005247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005248	Response regulator receiver domain; Region: Response_reg; pfam00072
447217005249	active site
447217005250	phosphorylation site [posttranslational modification]
447217005251	intermolecular recognition site; other site
447217005252	dimerization interface [polypeptide binding]; other site
447217005253	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
447217005254	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
447217005255	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
447217005256	G1 box; other site
447217005257	putative GEF interaction site [polypeptide binding]; other site
447217005258	GTP/Mg2+ binding site [chemical binding]; other site
447217005259	Switch I region; other site
447217005260	G2 box; other site
447217005261	G3 box; other site
447217005262	Switch II region; other site
447217005263	G4 box; other site
447217005264	G5 box; other site
447217005265	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
447217005266	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
447217005267	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217005268	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217005269	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
447217005270	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217005271	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217005272	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
447217005273	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
447217005274	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
447217005275	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
447217005276	active site
447217005277	dimer interface [polypeptide binding]; other site
447217005278	motif 1; other site
447217005279	motif 2; other site
447217005280	motif 3; other site
447217005281	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
447217005282	anticodon binding site; other site
447217005283	2-isopropylmalate synthase; Validated; Region: PRK00915
447217005284	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
447217005285	active site
447217005286	catalytic residues [active]
447217005287	metal binding site [ion binding]; metal-binding site
447217005288	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
447217005289	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
447217005290	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
447217005291	substrate binding site [chemical binding]; other site
447217005292	ligand binding site [chemical binding]; other site
447217005293	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
447217005294	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
447217005295	substrate binding site [chemical binding]; other site
447217005296	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
447217005297	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
447217005298	PYR/PP interface [polypeptide binding]; other site
447217005299	dimer interface [polypeptide binding]; other site
447217005300	TPP binding site [chemical binding]; other site
447217005301	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
447217005302	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
447217005303	TPP-binding site [chemical binding]; other site
447217005304	dimer interface [polypeptide binding]; other site
447217005305	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
447217005306	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
447217005307	putative valine binding site [chemical binding]; other site
447217005308	dimer interface [polypeptide binding]; other site
447217005309	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
447217005310	ketol-acid reductoisomerase; Provisional; Region: PRK05479
447217005311	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
447217005312	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
447217005313	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
447217005314	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
447217005315	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
447217005316	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
447217005317	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
447217005318	23S rRNA binding site [nucleotide binding]; other site
447217005319	L21 binding site [polypeptide binding]; other site
447217005320	L13 binding site [polypeptide binding]; other site
447217005321	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
447217005322	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
447217005323	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
447217005324	dimer interface [polypeptide binding]; other site
447217005325	motif 1; other site
447217005326	active site
447217005327	motif 2; other site
447217005328	motif 3; other site
447217005329	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
447217005330	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
447217005331	putative tRNA-binding site [nucleotide binding]; other site
447217005332	B3/4 domain; Region: B3_4; pfam03483
447217005333	tRNA synthetase B5 domain; Region: B5; pfam03484
447217005334	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217005335	active site
447217005336	dimer interface [polypeptide binding]; other site
447217005337	motif 2; other site
447217005338	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
447217005339	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217005340	IHF dimer interface [polypeptide binding]; other site
447217005341	IHF - DNA interface [nucleotide binding]; other site
447217005342	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217005343	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217005344	iron-sulfur cluster [ion binding]; other site
447217005345	[2Fe-2S] cluster binding site [ion binding]; other site
447217005346	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
447217005347	active site
447217005348	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
447217005349	active site
447217005350	classical (c) SDRs; Region: SDR_c; cd05233
447217005351	NAD(P) binding site [chemical binding]; other site
447217005352	active site
447217005353	FAD binding domain; Region: FAD_binding_4; pfam01565
447217005354	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
447217005355	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
447217005356	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
447217005357	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217005358	dimer interface [polypeptide binding]; other site
447217005359	PYR/PP interface [polypeptide binding]; other site
447217005360	TPP binding site [chemical binding]; other site
447217005361	substrate binding site [chemical binding]; other site
447217005362	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
447217005363	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217005364	TPP-binding site [chemical binding]; other site
447217005365	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
447217005366	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
447217005367	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
447217005368	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217005369	dimer interface [polypeptide binding]; other site
447217005370	PYR/PP interface [polypeptide binding]; other site
447217005371	TPP binding site [chemical binding]; other site
447217005372	substrate binding site [chemical binding]; other site
447217005373	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
447217005374	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217005375	TPP-binding site [chemical binding]; other site
447217005376	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
447217005377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217005378	TPR repeat; Region: TPR_11; pfam13414
447217005379	binding surface
447217005380	TPR motif; other site
447217005381	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
447217005382	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
447217005383	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217005384	NAD binding site [chemical binding]; other site
447217005385	putative substrate binding site 2 [chemical binding]; other site
447217005386	putative substrate binding site 1 [chemical binding]; other site
447217005387	active site
447217005388	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217005389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005390	NAD(P) binding site [chemical binding]; other site
447217005391	active site
447217005392	Transglycosylase; Region: Transgly; pfam00912
447217005393	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
447217005394	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
447217005395	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217005396	minor groove reading motif; other site
447217005397	helix-hairpin-helix signature motif; other site
447217005398	substrate binding pocket [chemical binding]; other site
447217005399	active site
447217005400	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
447217005401	DNA binding and oxoG recognition site [nucleotide binding]
447217005402	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
447217005403	S17 interaction site [polypeptide binding]; other site
447217005404	S8 interaction site; other site
447217005405	16S rRNA interaction site [nucleotide binding]; other site
447217005406	streptomycin interaction site [chemical binding]; other site
447217005407	23S rRNA interaction site [nucleotide binding]; other site
447217005408	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
447217005409	30S ribosomal protein S7; Validated; Region: PRK05302
447217005410	elongation factor G; Reviewed; Region: PRK00007
447217005411	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
447217005412	G1 box; other site
447217005413	putative GEF interaction site [polypeptide binding]; other site
447217005414	GTP/Mg2+ binding site [chemical binding]; other site
447217005415	Switch I region; other site
447217005416	G2 box; other site
447217005417	G3 box; other site
447217005418	Switch II region; other site
447217005419	G4 box; other site
447217005420	G5 box; other site
447217005421	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217005422	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217005423	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217005424	elongation factor Tu; Reviewed; Region: PRK00049
447217005425	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
447217005426	G1 box; other site
447217005427	GEF interaction site [polypeptide binding]; other site
447217005428	GTP/Mg2+ binding site [chemical binding]; other site
447217005429	Switch I region; other site
447217005430	G2 box; other site
447217005431	G3 box; other site
447217005432	Switch II region; other site
447217005433	G4 box; other site
447217005434	G5 box; other site
447217005435	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
447217005436	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
447217005437	Antibiotic Binding Site [chemical binding]; other site
447217005438	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
447217005439	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
447217005440	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
447217005441	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
447217005442	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
447217005443	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
447217005444	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
447217005445	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
447217005446	protein-rRNA interface [nucleotide binding]; other site
447217005447	putative translocon binding site; other site
447217005448	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
447217005449	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
447217005450	G-X-X-G motif; other site
447217005451	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
447217005452	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
447217005453	23S rRNA interface [nucleotide binding]; other site
447217005454	5S rRNA interface [nucleotide binding]; other site
447217005455	putative antibiotic binding site [chemical binding]; other site
447217005456	L25 interface [polypeptide binding]; other site
447217005457	L27 interface [polypeptide binding]; other site
447217005458	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
447217005459	23S rRNA interface [nucleotide binding]; other site
447217005460	putative translocon interaction site; other site
447217005461	signal recognition particle (SRP54) interaction site; other site
447217005462	L23 interface [polypeptide binding]; other site
447217005463	trigger factor interaction site; other site
447217005464	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
447217005465	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
447217005466	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
447217005467	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
447217005468	RNA binding site [nucleotide binding]; other site
447217005469	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
447217005470	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
447217005471	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
447217005472	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
447217005473	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
447217005474	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
447217005475	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
447217005476	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
447217005477	5S rRNA interface [nucleotide binding]; other site
447217005478	L27 interface [polypeptide binding]; other site
447217005479	L5 interface [polypeptide binding]; other site
447217005480	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
447217005481	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
447217005482	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
447217005483	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
447217005484	23S rRNA binding site [nucleotide binding]; other site
447217005485	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
447217005486	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
447217005487	SecY translocase; Region: SecY; pfam00344
447217005488	adenylate kinase; Reviewed; Region: adk; PRK00279
447217005489	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
447217005490	AMP-binding site [chemical binding]; other site
447217005491	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
447217005492	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217005493	active site
447217005494	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
447217005495	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
447217005496	30S ribosomal protein S13; Region: bact_S13; TIGR03631
447217005497	30S ribosomal protein S11; Validated; Region: PRK05309
447217005498	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
447217005499	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
447217005500	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217005501	RNA binding surface [nucleotide binding]; other site
447217005502	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
447217005503	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
447217005504	alphaNTD homodimer interface [polypeptide binding]; other site
447217005505	alphaNTD - beta interaction site [polypeptide binding]; other site
447217005506	alphaNTD - beta' interaction site [polypeptide binding]; other site
447217005507	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
447217005508	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
447217005509	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14525
447217005510	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
447217005511	KH domain; Region: KH_4; pfam13083
447217005512	G-X-X-G motif; other site
447217005513	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
447217005514	RimM N-terminal domain; Region: RimM; pfam01782
447217005515	PRC-barrel domain; Region: PRC; pfam05239
447217005516	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
447217005517	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
447217005518	hypothetical protein; Reviewed; Region: PRK12497
447217005519	Predicted methyltransferases [General function prediction only]; Region: COG0313
447217005520	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
447217005521	putative SAM binding site [chemical binding]; other site
447217005522	putative homodimer interface [polypeptide binding]; other site
447217005523	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005525	active site
447217005526	phosphorylation site [posttranslational modification]
447217005527	intermolecular recognition site; other site
447217005528	dimerization interface [polypeptide binding]; other site
447217005529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005530	Walker A motif; other site
447217005531	ATP binding site [chemical binding]; other site
447217005532	Walker B motif; other site
447217005533	arginine finger; other site
447217005534	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217005535	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217005536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005538	dimer interface [polypeptide binding]; other site
447217005539	phosphorylation site [posttranslational modification]
447217005540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005541	ATP binding site [chemical binding]; other site
447217005542	Mg2+ binding site [ion binding]; other site
447217005543	G-X-G motif; other site
447217005544	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217005545	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
447217005546	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217005547	catalytic residue [active]
447217005548	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217005549	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217005550	active site
447217005551	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
447217005552	DnaJ domain; Region: DnaJ; pfam00226
447217005553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217005554	non-specific DNA binding site [nucleotide binding]; other site
447217005555	salt bridge; other site
447217005556	sequence-specific DNA binding site [nucleotide binding]; other site
447217005557	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217005558	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217005559	RNA binding surface [nucleotide binding]; other site
447217005560	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217005561	active site
447217005562	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217005563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217005564	binding surface
447217005565	TPR motif; other site
447217005566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217005567	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217005568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217005569	Walker A/P-loop; other site
447217005570	ATP binding site [chemical binding]; other site
447217005571	Q-loop/lid; other site
447217005572	ABC transporter signature motif; other site
447217005573	Walker B; other site
447217005574	D-loop; other site
447217005575	H-loop/switch region; other site
447217005576	arginine decarboxylase; Provisional; Region: PRK05354
447217005577	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
447217005578	active site
447217005579	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217005580	catalytic residues [active]
447217005581	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
447217005582	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
447217005583	Dodecin; Region: Dodecin; pfam07311
447217005584	methionine sulfoxide reductase A; Provisional; Region: PRK00058
447217005585	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217005586	heme-binding residues [chemical binding]; other site
447217005587	HYR domain; Region: HYR; pfam02494
447217005588	5' nucleotidase family; Region: 5_nucleotid; pfam05761
447217005589	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217005590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217005591	sequence-specific DNA binding site [nucleotide binding]; other site
447217005592	salt bridge; other site
447217005593	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217005594	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217005595	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217005596	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217005597	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217005598	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217005599	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217005600	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217005601	active site
447217005602	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
447217005603	Permease; Region: Permease; pfam02405
447217005604	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217005605	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
447217005606	Walker A/P-loop; other site
447217005607	ATP binding site [chemical binding]; other site
447217005608	Q-loop/lid; other site
447217005609	ABC transporter signature motif; other site
447217005610	Walker B; other site
447217005611	D-loop; other site
447217005612	H-loop/switch region; other site
447217005613	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
447217005614	mce related protein; Region: MCE; pfam02470
447217005615	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217005616	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217005617	catalytic residues [active]
447217005618	Domain of unknown function (DUF329); Region: DUF329; pfam03884
447217005619	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
447217005620	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
447217005621	dimerization interface [polypeptide binding]; other site
447217005622	ligand binding site [chemical binding]; other site
447217005623	NADP binding site [chemical binding]; other site
447217005624	catalytic site [active]
447217005625	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
447217005626	Beta propeller domain; Region: Beta_propel; pfam09826
447217005627	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
447217005628	active site
447217005629	oxyanion hole [active]
447217005630	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217005631	enoyl-CoA hydratase; Validated; Region: PRK08139
447217005632	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217005633	substrate binding site [chemical binding]; other site
447217005634	oxyanion hole (OAH) forming residues; other site
447217005635	trimer interface [polypeptide binding]; other site
447217005636	GAF domain; Region: GAF; pfam01590
447217005637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005639	ATP binding site [chemical binding]; other site
447217005640	Mg2+ binding site [ion binding]; other site
447217005641	G-X-G motif; other site
447217005642	Helix-turn-helix domain; Region: HTH_17; pfam12728
447217005643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
447217005644	non-specific DNA binding site [nucleotide binding]; other site
447217005645	salt bridge; other site
447217005646	sequence-specific DNA binding site [nucleotide binding]; other site
447217005647	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
447217005648	active site
447217005649	Int/Topo IB signature motif; other site
447217005650	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
447217005651	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
447217005652	B12 binding site [chemical binding]; other site
447217005653	cobalt ligand [ion binding]; other site
447217005654	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
447217005655	active site
447217005656	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
447217005657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217005658	FeS/SAM binding site; other site
447217005659	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
447217005660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005661	active site
447217005662	phosphorylation site [posttranslational modification]
447217005663	intermolecular recognition site; other site
447217005664	dimerization interface [polypeptide binding]; other site
447217005665	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217005666	Zn2+ binding site [ion binding]; other site
447217005667	Mg2+ binding site [ion binding]; other site
447217005668	lipoyl synthase; Provisional; Region: PRK05481
447217005669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217005670	FeS/SAM binding site; other site
447217005671	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
447217005672	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
447217005673	TPP-binding site [chemical binding]; other site
447217005674	tetramer interface [polypeptide binding]; other site
447217005675	heterodimer interface [polypeptide binding]; other site
447217005676	phosphorylation loop region [posttranslational modification]
447217005677	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
447217005678	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
447217005679	alpha subunit interface [polypeptide binding]; other site
447217005680	TPP binding site [chemical binding]; other site
447217005681	heterodimer interface [polypeptide binding]; other site
447217005682	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
447217005683	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217005684	E3 interaction surface; other site
447217005685	lipoyl attachment site [posttranslational modification]; other site
447217005686	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
447217005687	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
447217005688	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
447217005689	active site
447217005690	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
447217005691	putative ATP binding site [chemical binding]; other site
447217005692	putative substrate interface [chemical binding]; other site
447217005693	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
447217005694	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
447217005695	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217005696	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217005697	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
447217005698	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
447217005699	nudix motif; other site
447217005700	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217005701	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217005702	active site
447217005703	ATP binding site [chemical binding]; other site
447217005704	substrate binding site [chemical binding]; other site
447217005705	activation loop (A-loop); other site
447217005706	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217005707	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217005708	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217005709	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217005710	active site
447217005711	ATP binding site [chemical binding]; other site
447217005712	substrate binding site [chemical binding]; other site
447217005713	activation loop (A-loop); other site
447217005714	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217005715	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217005716	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217005717	phosphopeptide binding site; other site
447217005718	aspartate kinase; Validated; Region: PRK09181
447217005719	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
447217005720	nucleotide binding site [chemical binding]; other site
447217005721	substrate binding site [chemical binding]; other site
447217005722	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217005723	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217005724	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
447217005725	active sites [active]
447217005726	tetramer interface [polypeptide binding]; other site
447217005727	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
447217005728	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
447217005729	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
447217005730	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217005731	DXD motif; other site
447217005732	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
447217005733	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
447217005734	active site
447217005735	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
447217005736	Part of AAA domain; Region: AAA_19; pfam13245
447217005737	Family description; Region: UvrD_C_2; pfam13538
447217005738	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217005739	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
447217005740	nucleotide binding site [chemical binding]; other site
447217005741	SCP-2 sterol transfer family; Region: SCP2; cl01225
447217005742	PAS fold; Region: PAS_4; pfam08448
447217005743	PAS domain; Region: PAS; smart00091
447217005744	putative active site [active]
447217005745	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217005746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005747	dimer interface [polypeptide binding]; other site
447217005748	phosphorylation site [posttranslational modification]
447217005749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005750	ATP binding site [chemical binding]; other site
447217005751	Mg2+ binding site [ion binding]; other site
447217005752	G-X-G motif; other site
447217005753	pyrophosphatase PpaX; Provisional; Region: PRK13288
447217005754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217005755	active site
447217005756	motif I; other site
447217005757	motif II; other site
447217005758	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
447217005759	prephenate dehydratase; Provisional; Region: PRK11898
447217005760	Prephenate dehydratase; Region: PDT; pfam00800
447217005761	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
447217005762	putative L-Phe binding site [chemical binding]; other site
447217005763	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
447217005764	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
447217005765	active site
447217005766	nucleophile elbow; other site
447217005767	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
447217005768	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
447217005769	Beta-Casp domain; Region: Beta-Casp; smart01027
447217005770	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
447217005771	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
447217005772	active site
447217005773	8-oxo-dGMP binding site [chemical binding]; other site
447217005774	nudix motif; other site
447217005775	metal binding site [ion binding]; metal-binding site
447217005776	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217005777	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217005778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005779	Walker A motif; other site
447217005780	ATP binding site [chemical binding]; other site
447217005781	Walker B motif; other site
447217005782	arginine finger; other site
447217005783	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217005784	GrpE; Region: GrpE; pfam01025
447217005785	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
447217005786	dimer interface [polypeptide binding]; other site
447217005787	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
447217005788	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217005789	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217005790	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217005791	protein binding site [polypeptide binding]; other site
447217005792	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217005793	protein binding site [polypeptide binding]; other site
447217005794	PilZ domain; Region: PilZ; cl01260
447217005795	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
447217005796	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217005797	Walker A/P-loop; other site
447217005798	ATP binding site [chemical binding]; other site
447217005799	Q-loop/lid; other site
447217005800	ABC transporter signature motif; other site
447217005801	Walker B; other site
447217005802	D-loop; other site
447217005803	H-loop/switch region; other site
447217005804	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
447217005805	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
447217005806	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
447217005807	NAD(P) binding site [chemical binding]; other site
447217005808	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
447217005809	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
447217005810	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217005811	dimerization interface [polypeptide binding]; other site
447217005812	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
447217005813	Histidine kinase; Region: HisKA_3; pfam07730
447217005814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005815	Mg2+ binding site [ion binding]; other site
447217005816	G-X-G motif; other site
447217005817	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217005818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005819	active site
447217005820	phosphorylation site [posttranslational modification]
447217005821	intermolecular recognition site; other site
447217005822	dimerization interface [polypeptide binding]; other site
447217005823	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217005824	DNA binding residues [nucleotide binding]
447217005825	dimerization interface [polypeptide binding]; other site
447217005826	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
447217005827	gating phenylalanine in ion channel; other site
447217005828	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217005829	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217005830	substrate binding pocket [chemical binding]; other site
447217005831	membrane-bound complex binding site; other site
447217005832	hinge residues; other site
447217005833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005834	ATP binding site [chemical binding]; other site
447217005835	Mg2+ binding site [ion binding]; other site
447217005836	G-X-G motif; other site
447217005837	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005839	active site
447217005840	phosphorylation site [posttranslational modification]
447217005841	intermolecular recognition site; other site
447217005842	dimerization interface [polypeptide binding]; other site
447217005843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005844	Walker A motif; other site
447217005845	ATP binding site [chemical binding]; other site
447217005846	Walker B motif; other site
447217005847	arginine finger; other site
447217005848	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217005849	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
447217005850	Aspartase; Region: Aspartase; cd01357
447217005851	active sites [active]
447217005852	tetramer interface [polypeptide binding]; other site
447217005853	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
447217005854	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
447217005855	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
447217005856	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
447217005857	trimer interface [polypeptide binding]; other site
447217005858	eyelet of channel; other site
447217005859	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
447217005860	heme-binding site [chemical binding]; other site
447217005861	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217005862	Coenzyme A binding pocket [chemical binding]; other site
447217005863	RES domain; Region: RES; cl02411
447217005864	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
447217005865	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
447217005866	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
447217005867	Beta-lactamase; Region: Beta-lactamase; pfam00144
447217005868	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
447217005869	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
447217005870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005871	Walker A motif; other site
447217005872	ATP binding site [chemical binding]; other site
447217005873	Walker B motif; other site
447217005874	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
447217005875	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
447217005876	active site
447217005877	catalytic triad [active]
447217005878	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217005879	active site
447217005880	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217005881	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217005882	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217005883	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217005884	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217005885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
447217005886	Serine hydrolase; Region: Ser_hydrolase; cl17834
447217005887	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217005888	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
447217005889	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
447217005890	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217005891	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
447217005892	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
447217005893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217005894	Walker A/P-loop; other site
447217005895	ATP binding site [chemical binding]; other site
447217005896	Q-loop/lid; other site
447217005897	ABC transporter signature motif; other site
447217005898	Walker B; other site
447217005899	D-loop; other site
447217005900	H-loop/switch region; other site
447217005901	TOBE-like domain; Region: TOBE_3; pfam12857
447217005902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217005903	dimer interface [polypeptide binding]; other site
447217005904	conserved gate region; other site
447217005905	putative PBP binding loops; other site
447217005906	ABC-ATPase subunit interface; other site
447217005907	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
447217005908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217005909	dimer interface [polypeptide binding]; other site
447217005910	conserved gate region; other site
447217005911	putative PBP binding loops; other site
447217005912	ABC-ATPase subunit interface; other site
447217005913	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
447217005914	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
447217005915	Active Sites [active]
447217005916	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
447217005917	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
447217005918	CysD dimerization site [polypeptide binding]; other site
447217005919	G1 box; other site
447217005920	putative GEF interaction site [polypeptide binding]; other site
447217005921	GTP/Mg2+ binding site [chemical binding]; other site
447217005922	Switch I region; other site
447217005923	G2 box; other site
447217005924	G3 box; other site
447217005925	Switch II region; other site
447217005926	G4 box; other site
447217005927	G5 box; other site
447217005928	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
447217005929	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
447217005930	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
447217005931	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
447217005932	Active Sites [active]
447217005933	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
447217005934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217005935	S-adenosylmethionine binding site [chemical binding]; other site
447217005936	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
447217005937	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
447217005938	active site
447217005939	(T/H)XGH motif; other site
447217005940	aspartate aminotransferase; Provisional; Region: PRK05764
447217005941	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217005942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005943	homodimer interface [polypeptide binding]; other site
447217005944	catalytic residue [active]
447217005945	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217005946	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
447217005947	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217005948	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
447217005949	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
447217005950	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217005951	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217005952	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
447217005953	IMP binding site; other site
447217005954	dimer interface [polypeptide binding]; other site
447217005955	interdomain contacts; other site
447217005956	partial ornithine binding site; other site
447217005957	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
447217005958	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
447217005959	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217005960	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
447217005961	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
447217005962	generic binding surface II; other site
447217005963	ssDNA binding site; other site
447217005964	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217005965	ATP binding site [chemical binding]; other site
447217005966	putative Mg++ binding site [ion binding]; other site
447217005967	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217005968	nucleotide binding region [chemical binding]; other site
447217005969	ATP-binding site [chemical binding]; other site
447217005970	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135
447217005971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217005972	S-adenosylmethionine binding site [chemical binding]; other site
447217005973	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
447217005974	aminotransferase; Validated; Region: PRK08175
447217005975	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217005976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005977	homodimer interface [polypeptide binding]; other site
447217005978	catalytic residue [active]
447217005979	threonine synthase; Region: PLN02569
447217005980	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
447217005981	homodimer interface [polypeptide binding]; other site
447217005982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005983	catalytic residue [active]
447217005984	thymidylate kinase; Region: DTMP_kinase; TIGR00041
447217005985	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
447217005986	TMP-binding site; other site
447217005987	ATP-binding site [chemical binding]; other site
447217005988	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
447217005989	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
447217005990	putative MPT binding site; other site
447217005991	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217005992	Cytochrome c; Region: Cytochrom_C; pfam00034
447217005993	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
447217005994	Di-iron ligands [ion binding]; other site
447217005995	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217005996	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217005997	putative acyl-acceptor binding pocket; other site
447217005998	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
447217005999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006000	ATP binding site [chemical binding]; other site
447217006001	Mg2+ binding site [ion binding]; other site
447217006002	G-X-G motif; other site
447217006003	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
447217006004	ATP binding site [chemical binding]; other site
447217006005	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
447217006006	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
447217006007	phosphopeptide binding site; other site
447217006008	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
447217006009	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217006010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006011	Walker A motif; other site
447217006012	ATP binding site [chemical binding]; other site
447217006013	Walker B motif; other site
447217006014	arginine finger; other site
447217006015	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217006016	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217006017	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217006018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217006019	active site
447217006020	ATP binding site [chemical binding]; other site
447217006021	substrate binding site [chemical binding]; other site
447217006022	activation loop (A-loop); other site
447217006023	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006024	active site
447217006025	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217006026	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
447217006027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006028	Walker A motif; other site
447217006029	ATP binding site [chemical binding]; other site
447217006030	Walker B motif; other site
447217006031	arginine finger; other site
447217006032	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
447217006033	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
447217006034	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217006035	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
447217006036	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
447217006037	LexA repressor; Validated; Region: PRK00215
447217006038	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
447217006039	Catalytic site [active]
447217006040	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
447217006041	ABC1 family; Region: ABC1; cl17513
447217006042	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
447217006043	active site
447217006044	ATP binding site [chemical binding]; other site
447217006045	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
447217006046	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217006047	active site
447217006048	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
447217006049	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
447217006050	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
447217006051	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
447217006052	NodB motif; other site
447217006053	putative active site [active]
447217006054	putative catalytic site [active]
447217006055	putative Zn binding site [ion binding]; other site
447217006056	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
447217006057	MutS domain I; Region: MutS_I; pfam01624
447217006058	MutS domain III; Region: MutS_III; pfam05192
447217006059	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
447217006060	Walker A/P-loop; other site
447217006061	ATP binding site [chemical binding]; other site
447217006062	Q-loop/lid; other site
447217006063	ABC transporter signature motif; other site
447217006064	Walker B; other site
447217006065	D-loop; other site
447217006066	H-loop/switch region; other site
447217006067	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217006068	heme-binding residues [chemical binding]; other site
447217006069	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217006070	heme-binding residues [chemical binding]; other site
447217006071	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
447217006072	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
447217006073	conserved cys residue [active]
447217006074	AMIN domain; Region: AMIN; pfam11741
447217006075	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
447217006076	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
447217006077	active site
447217006078	metal binding site [ion binding]; metal-binding site
447217006079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
447217006080	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217006081	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217006082	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
447217006083	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
447217006084	PII uridylyl-transferase; Provisional; Region: PRK05092
447217006085	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217006086	metal binding triad; other site
447217006087	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217006088	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217006089	Zn2+ binding site [ion binding]; other site
447217006090	Mg2+ binding site [ion binding]; other site
447217006091	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
447217006092	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
447217006093	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217006094	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
447217006095	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
447217006096	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
447217006097	active site
447217006098	Int/Topo IB signature motif; other site
447217006099	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
447217006100	Peptidase family M50; Region: Peptidase_M50; pfam02163
447217006101	active site
447217006102	putative substrate binding region [chemical binding]; other site
447217006103	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
447217006104	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
447217006105	active site
447217006106	HIGH motif; other site
447217006107	dimer interface [polypeptide binding]; other site
447217006108	KMSKS motif; other site
447217006109	ScpA/B protein; Region: ScpA_ScpB; cl00598
447217006110	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
447217006111	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
447217006112	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217006113	RNA binding surface [nucleotide binding]; other site
447217006114	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
447217006115	active site
447217006116	Secretin and TonB N terminus short domain; Region: STN; pfam07660
447217006117	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
447217006118	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217006119	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217006120	DNA binding residues [nucleotide binding]
447217006121	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
447217006122	transmembrane helices; other site
447217006123	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
447217006124	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
447217006125	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
447217006126	putative active site [active]
447217006127	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
447217006128	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
447217006129	oligomer interface [polypeptide binding]; other site
447217006130	metal binding site [ion binding]; metal-binding site
447217006131	metal binding site [ion binding]; metal-binding site
447217006132	putative Cl binding site [ion binding]; other site
447217006133	aspartate ring; other site
447217006134	basic sphincter; other site
447217006135	hydrophobic gate; other site
447217006136	periplasmic entrance; other site
447217006137	Domain of unknown function DUF59; Region: DUF59; pfam01883
447217006138	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
447217006139	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
447217006140	Walker A motif; other site
447217006141	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
447217006142	active site
447217006143	catalytic residues [active]
447217006144	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
447217006145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006146	PAS domain; Region: PAS_9; pfam13426
447217006147	putative active site [active]
447217006148	heme pocket [chemical binding]; other site
447217006149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006151	dimer interface [polypeptide binding]; other site
447217006152	phosphorylation site [posttranslational modification]
447217006153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006154	ATP binding site [chemical binding]; other site
447217006155	Mg2+ binding site [ion binding]; other site
447217006156	G-X-G motif; other site
447217006157	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
447217006158	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
447217006159	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217006160	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
447217006161	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217006162	substrate binding site [chemical binding]; other site
447217006163	oxyanion hole (OAH) forming residues; other site
447217006164	trimer interface [polypeptide binding]; other site
447217006165	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217006166	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
447217006167	FAD binding site [chemical binding]; other site
447217006168	homotetramer interface [polypeptide binding]; other site
447217006169	substrate binding pocket [chemical binding]; other site
447217006170	catalytic base [active]
447217006171	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217006172	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217006173	active site
447217006174	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217006175	dimerization interface [polypeptide binding]; other site
447217006176	active site
447217006177	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
447217006178	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
447217006179	DNA binding residues [nucleotide binding]
447217006180	dimer interface [polypeptide binding]; other site
447217006181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
447217006182	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217006183	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217006184	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217006185	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
447217006186	active site
447217006187	8-oxo-dGMP binding site [chemical binding]; other site
447217006188	nudix motif; other site
447217006189	metal binding site [ion binding]; metal-binding site
447217006190	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
447217006191	PQQ-like domain; Region: PQQ_2; pfam13360
447217006192	Trp docking motif [polypeptide binding]; other site
447217006193	active site
447217006194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
447217006195	GTP-binding protein Der; Reviewed; Region: PRK00093
447217006196	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
447217006197	G1 box; other site
447217006198	GTP/Mg2+ binding site [chemical binding]; other site
447217006199	Switch I region; other site
447217006200	G2 box; other site
447217006201	Switch II region; other site
447217006202	G3 box; other site
447217006203	G4 box; other site
447217006204	G5 box; other site
447217006205	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
447217006206	G1 box; other site
447217006207	GTP/Mg2+ binding site [chemical binding]; other site
447217006208	Switch I region; other site
447217006209	G2 box; other site
447217006210	G3 box; other site
447217006211	Switch II region; other site
447217006212	G4 box; other site
447217006213	G5 box; other site
447217006214	GTPase Era; Reviewed; Region: era; PRK00089
447217006215	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
447217006216	G1 box; other site
447217006217	GTP/Mg2+ binding site [chemical binding]; other site
447217006218	Switch I region; other site
447217006219	G2 box; other site
447217006220	Switch II region; other site
447217006221	G3 box; other site
447217006222	G4 box; other site
447217006223	G5 box; other site
447217006224	KH domain; Region: KH_2; pfam07650
447217006225	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217006226	active site
447217006227	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217006228	active site
447217006229	ribonuclease III; Reviewed; Region: rnc; PRK00102
447217006230	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
447217006231	dimerization interface [polypeptide binding]; other site
447217006232	active site
447217006233	metal binding site [ion binding]; metal-binding site
447217006234	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
447217006235	dsRNA binding site [nucleotide binding]; other site
447217006236	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
447217006237	Walker A; other site
447217006238	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
447217006239	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217006240	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217006241	active site
447217006242	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217006243	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
447217006244	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
447217006245	enoyl-CoA hydratase; Provisional; Region: PRK06688
447217006246	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217006247	substrate binding site [chemical binding]; other site
447217006248	oxyanion hole (OAH) forming residues; other site
447217006249	trimer interface [polypeptide binding]; other site
447217006250	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
447217006251	active site
447217006252	catalytic residues [active]
447217006253	metal binding site [ion binding]; metal-binding site
447217006254	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217006255	active site residue [active]
447217006256	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
447217006257	ThiC family; Region: ThiC; pfam01964
447217006258	enolase; Provisional; Region: eno; PRK00077
447217006259	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
447217006260	dimer interface [polypeptide binding]; other site
447217006261	metal binding site [ion binding]; metal-binding site
447217006262	substrate binding pocket [chemical binding]; other site
447217006263	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
447217006264	hydrophobic ligand binding site; other site
447217006265	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
447217006266	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
447217006267	putative active site [active]
447217006268	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217006269	active site
447217006270	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
447217006271	homoserine dehydrogenase; Provisional; Region: PRK06349
447217006272	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217006273	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
447217006274	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217006275	HEAT repeats; Region: HEAT_2; pfam13646
447217006276	Restriction endonuclease; Region: Mrr_cat; pfam04471
447217006277	PQQ-like domain; Region: PQQ_2; pfam13360
447217006278	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
447217006279	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217006280	active site
447217006281	metal binding site [ion binding]; metal-binding site
447217006282	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217006283	substrate binding site [chemical binding]; other site
447217006284	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
447217006285	ATP binding site [chemical binding]; other site
447217006286	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
447217006287	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217006288	FeS/SAM binding site; other site
447217006289	Domain of unknown function DUF21; Region: DUF21; pfam01595
447217006290	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
447217006291	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217006292	Transporter associated domain; Region: CorC_HlyC; smart01091
447217006293	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
447217006294	active site
447217006295	multimer interface [polypeptide binding]; other site
447217006296	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
447217006297	CoA binding domain; Region: CoA_binding; pfam02629
447217006298	CoA-ligase; Region: Ligase_CoA; pfam00549
447217006299	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
447217006300	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
447217006301	CoA-ligase; Region: Ligase_CoA; pfam00549
447217006302	malate dehydrogenase; Reviewed; Region: PRK06223
447217006303	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
447217006304	NAD(P) binding site [chemical binding]; other site
447217006305	dimer interface [polypeptide binding]; other site
447217006306	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217006307	substrate binding site [chemical binding]; other site
447217006308	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
447217006309	isocitrate dehydrogenase; Validated; Region: PRK07362
447217006310	YdjC-like protein; Region: YdjC; pfam04794
447217006311	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217006312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006313	putative active site [active]
447217006314	heme pocket [chemical binding]; other site
447217006315	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217006316	phosphorylation site [posttranslational modification]
447217006317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006318	ATP binding site [chemical binding]; other site
447217006319	Mg2+ binding site [ion binding]; other site
447217006320	G-X-G motif; other site
447217006321	Bifunctional nuclease; Region: DNase-RNase; cl00553
447217006322	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
447217006323	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
447217006324	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
447217006325	catalytic site [active]
447217006326	subunit interface [polypeptide binding]; other site
447217006327	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217006328	dihydroorotase; Validated; Region: pyrC; PRK09357
447217006329	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
447217006330	active site
447217006331	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
447217006332	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
447217006333	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
447217006334	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217006335	active site
447217006336	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
447217006337	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217006338	Catalytic site [active]
447217006339	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217006340	GTP-binding protein LepA; Provisional; Region: PRK05433
447217006341	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
447217006342	G1 box; other site
447217006343	putative GEF interaction site [polypeptide binding]; other site
447217006344	GTP/Mg2+ binding site [chemical binding]; other site
447217006345	Switch I region; other site
447217006346	G2 box; other site
447217006347	G3 box; other site
447217006348	Switch II region; other site
447217006349	G4 box; other site
447217006350	G5 box; other site
447217006351	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
447217006352	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
447217006353	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
447217006354	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
447217006355	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
447217006356	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
447217006357	active site
447217006358	dimer interface [polypeptide binding]; other site
447217006359	effector binding site; other site
447217006360	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
447217006361	TSCPD domain; Region: TSCPD; pfam12637
447217006362	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
447217006363	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
447217006364	putative active site [active]
447217006365	putative PHP Thumb interface [polypeptide binding]; other site
447217006366	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
447217006367	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
447217006368	generic binding surface I; other site
447217006369	generic binding surface II; other site
447217006370	Y-family of DNA polymerases; Region: PolY; cl12025
447217006371	active site
447217006372	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
447217006373	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217006374	Walker A motif; other site
447217006375	ATP binding site [chemical binding]; other site
447217006376	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217006377	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217006378	catalytic residues [active]
447217006379	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
447217006380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006381	active site
447217006382	phosphorylation site [posttranslational modification]
447217006383	intermolecular recognition site; other site
447217006384	dimerization interface [polypeptide binding]; other site
447217006385	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217006386	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217006387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006388	ATP binding site [chemical binding]; other site
447217006389	Mg2+ binding site [ion binding]; other site
447217006390	G-X-G motif; other site
447217006391	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
447217006392	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
447217006393	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
447217006394	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217006395	catalytic residue [active]
447217006396	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
447217006397	catalytic site [active]
447217006398	putative active site [active]
447217006399	putative substrate binding site [chemical binding]; other site
447217006400	HRDC domain; Region: HRDC; pfam00570
447217006401	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
447217006402	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217006403	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217006404	putative acyl-acceptor binding pocket; other site
447217006405	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006407	active site
447217006408	phosphorylation site [posttranslational modification]
447217006409	intermolecular recognition site; other site
447217006410	dimerization interface [polypeptide binding]; other site
447217006411	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
447217006412	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
447217006413	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217006414	Walker A motif; other site
447217006415	ATP binding site [chemical binding]; other site
447217006416	Walker B motif; other site
447217006417	flagellar assembly protein H; Validated; Region: fliH; PRK06669
447217006418	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
447217006419	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217006420	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217006421	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
447217006422	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
447217006423	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
447217006424	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
447217006425	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
447217006426	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
447217006427	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
447217006428	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
447217006429	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
447217006430	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
447217006431	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
447217006432	DNA binding site [nucleotide binding]
447217006433	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
447217006434	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
447217006435	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
447217006436	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
447217006437	RPB11 interaction site [polypeptide binding]; other site
447217006438	RPB12 interaction site [polypeptide binding]; other site
447217006439	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
447217006440	RPB3 interaction site [polypeptide binding]; other site
447217006441	RPB1 interaction site [polypeptide binding]; other site
447217006442	RPB11 interaction site [polypeptide binding]; other site
447217006443	RPB10 interaction site [polypeptide binding]; other site
447217006444	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
447217006445	core dimer interface [polypeptide binding]; other site
447217006446	peripheral dimer interface [polypeptide binding]; other site
447217006447	L10 interface [polypeptide binding]; other site
447217006448	L11 interface [polypeptide binding]; other site
447217006449	putative EF-Tu interaction site [polypeptide binding]; other site
447217006450	putative EF-G interaction site [polypeptide binding]; other site
447217006451	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
447217006452	23S rRNA interface [nucleotide binding]; other site
447217006453	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
447217006454	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
447217006455	mRNA/rRNA interface [nucleotide binding]; other site
447217006456	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
447217006457	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
447217006458	23S rRNA interface [nucleotide binding]; other site
447217006459	L7/L12 interface [polypeptide binding]; other site
447217006460	putative thiostrepton binding site; other site
447217006461	L25 interface [polypeptide binding]; other site
447217006462	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
447217006463	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
447217006464	putative homodimer interface [polypeptide binding]; other site
447217006465	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
447217006466	heterodimer interface [polypeptide binding]; other site
447217006467	homodimer interface [polypeptide binding]; other site
447217006468	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
447217006469	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
447217006470	elongation factor Tu; Reviewed; Region: PRK00049
447217006471	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
447217006472	G1 box; other site
447217006473	GEF interaction site [polypeptide binding]; other site
447217006474	GTP/Mg2+ binding site [chemical binding]; other site
447217006475	Switch I region; other site
447217006476	G2 box; other site
447217006477	G3 box; other site
447217006478	Switch II region; other site
447217006479	G4 box; other site
447217006480	G5 box; other site
447217006481	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
447217006482	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
447217006483	Antibiotic Binding Site [chemical binding]; other site
447217006484	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
447217006485	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
447217006486	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
447217006487	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
447217006488	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217006489	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217006490	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
447217006491	nucleotide binding site [chemical binding]; other site
447217006492	NEF interaction site [polypeptide binding]; other site
447217006493	SBD interface [polypeptide binding]; other site
447217006494	Protein of unknown function (DUF493); Region: DUF493; pfam04359
447217006495	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
447217006496	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
447217006497	putative active site [active]
447217006498	PhoH-like protein; Region: PhoH; pfam02562
447217006499	GAF domain; Region: GAF; cl17456
447217006500	GAF domain; Region: GAF_2; pfam13185
447217006501	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217006502	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217006503	metal binding site [ion binding]; metal-binding site
447217006504	active site
447217006505	I-site; other site
447217006506	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
447217006507	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217006508	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
447217006509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217006510	putative substrate translocation pore; other site
447217006511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217006512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217006513	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
447217006514	ApbE family; Region: ApbE; pfam02424
447217006515	FMN-binding domain; Region: FMN_bind; pfam04205
447217006516	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
447217006517	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
447217006518	FeoA domain; Region: FeoA; pfam04023
447217006519	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
447217006520	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
447217006521	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
447217006522	G1 box; other site
447217006523	GTP/Mg2+ binding site [chemical binding]; other site
447217006524	Switch I region; other site
447217006525	G2 box; other site
447217006526	G3 box; other site
447217006527	Switch II region; other site
447217006528	G4 box; other site
447217006529	G5 box; other site
447217006530	Nucleoside recognition; Region: Gate; pfam07670
447217006531	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
447217006532	Nucleoside recognition; Region: Gate; pfam07670
447217006533	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
447217006534	metal binding site 2 [ion binding]; metal-binding site
447217006535	putative DNA binding helix; other site
447217006536	metal binding site 1 [ion binding]; metal-binding site
447217006537	dimer interface [polypeptide binding]; other site
447217006538	structural Zn2+ binding site [ion binding]; other site
447217006539	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
447217006540	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006542	ATP binding site [chemical binding]; other site
447217006543	Mg2+ binding site [ion binding]; other site
447217006544	G-X-G motif; other site
447217006545	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
447217006546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217006547	binding surface
447217006548	TPR motif; other site
447217006549	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217006550	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006552	active site
447217006553	phosphorylation site [posttranslational modification]
447217006554	intermolecular recognition site; other site
447217006555	dimerization interface [polypeptide binding]; other site
447217006556	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217006557	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217006558	metal binding site [ion binding]; metal-binding site
447217006559	active site
447217006560	I-site; other site
447217006561	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217006562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006563	active site
447217006564	phosphorylation site [posttranslational modification]
447217006565	intermolecular recognition site; other site
447217006566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006567	Walker A motif; other site
447217006568	ATP binding site [chemical binding]; other site
447217006569	Walker B motif; other site
447217006570	arginine finger; other site
447217006571	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217006572	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
447217006573	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
447217006574	putative active site [active]
447217006575	putative metal binding site [ion binding]; other site
447217006576	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
447217006577	catalytic motif [active]
447217006578	Zn binding site [ion binding]; other site
447217006579	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217006580	PrkA AAA domain; Region: AAA_PrkA; smart00763
447217006581	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
447217006582	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217006583	nucleotide binding site [chemical binding]; other site
447217006584	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217006585	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
447217006586	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
447217006587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006588	Walker A motif; other site
447217006589	ATP binding site [chemical binding]; other site
447217006590	Walker B motif; other site
447217006591	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
447217006592	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
447217006593	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
447217006594	active site
447217006595	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
447217006596	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
447217006597	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
447217006598	Ligand Binding Site [chemical binding]; other site
447217006599	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
447217006600	active site
447217006601	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
447217006602	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
447217006603	ATP binding site [chemical binding]; other site
447217006604	substrate interface [chemical binding]; other site
447217006605	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217006606	CPxP  motif; other site
447217006607	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
447217006608	ATP binding site [chemical binding]; other site
447217006609	substrate interface [chemical binding]; other site
447217006610	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
447217006611	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217006612	putative chaperone; Provisional; Region: PRK11678
447217006613	nucleotide binding site [chemical binding]; other site
447217006614	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
447217006615	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
447217006616	Ferredoxin [Energy production and conversion]; Region: COG1146
447217006617	4Fe-4S binding domain; Region: Fer4; pfam00037
447217006618	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
447217006619	Preprotein translocase SecG subunit; Region: SecG; pfam03840
447217006620	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
447217006621	triosephosphate isomerase; Provisional; Region: PRK14565
447217006622	substrate binding site [chemical binding]; other site
447217006623	dimer interface [polypeptide binding]; other site
447217006624	catalytic triad [active]
447217006625	Phosphoglycerate kinase; Region: PGK; pfam00162
447217006626	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
447217006627	substrate binding site [chemical binding]; other site
447217006628	hinge regions; other site
447217006629	ADP binding site [chemical binding]; other site
447217006630	catalytic site [active]
447217006631	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
447217006632	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
447217006633	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
447217006634	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
447217006635	Cupin domain; Region: Cupin_2; cl17218
447217006636	Sporulation related domain; Region: SPOR; pfam05036
447217006637	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
447217006638	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
447217006639	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
447217006640	active site
447217006641	HIGH motif; other site
447217006642	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217006643	KMSK motif region; other site
447217006644	tRNA binding surface [nucleotide binding]; other site
447217006645	DALR anticodon binding domain; Region: DALR_1; smart00836
447217006646	anticodon binding site; other site
447217006647	tetratricopeptide repeat protein; Provisional; Region: PRK11788
447217006648	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
447217006649	nucleotide binding site/active site [active]
447217006650	HIT family signature motif; other site
447217006651	catalytic residue [active]
447217006652	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
447217006653	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
447217006654	tandem repeat interface [polypeptide binding]; other site
447217006655	oligomer interface [polypeptide binding]; other site
447217006656	active site residues [active]
447217006657	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
447217006658	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
447217006659	RNA binding site [nucleotide binding]; other site
447217006660	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
447217006661	RNA binding site [nucleotide binding]; other site
447217006662	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
447217006663	RNA binding site [nucleotide binding]; other site
447217006664	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217006665	RNA binding site [nucleotide binding]; other site
447217006666	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
447217006667	RNA binding site [nucleotide binding]; other site
447217006668	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
447217006669	RNA binding site [nucleotide binding]; other site
447217006670	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
447217006671	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
447217006672	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
447217006673	cytidylate kinase; Provisional; Region: cmk; PRK00023
447217006674	AAA domain; Region: AAA_17; pfam13207
447217006675	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
447217006676	CMP-binding site; other site
447217006677	The sites determining sugar specificity; other site
447217006678	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
447217006679	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
447217006680	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
447217006681	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
447217006682	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
447217006683	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
447217006684	dimer interface [polypeptide binding]; other site
447217006685	motif 1; other site
447217006686	active site
447217006687	motif 2; other site
447217006688	motif 3; other site
447217006689	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
447217006690	anticodon binding site; other site
447217006691	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
447217006692	urocanate hydratase; Provisional; Region: PRK05414
447217006693	imidazolonepropionase; Validated; Region: PRK09356
447217006694	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217006695	active site
447217006696	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
447217006697	active site
447217006698	metal binding site [ion binding]; metal-binding site
447217006699	homotetramer interface [polypeptide binding]; other site
447217006700	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
447217006701	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
447217006702	putative active site [active]
447217006703	putative dimer interface [polypeptide binding]; other site
447217006704	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
447217006705	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
447217006706	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
447217006707	putative substrate binding site [chemical binding]; other site
447217006708	putative ATP binding site [chemical binding]; other site
447217006709	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
447217006710	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
447217006711	active site
447217006712	hydrophilic channel; other site
447217006713	dimerization interface [polypeptide binding]; other site
447217006714	catalytic residues [active]
447217006715	active site lid [active]
447217006716	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
447217006717	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
447217006718	active site
447217006719	substrate binding site [chemical binding]; other site
447217006720	metal binding site [ion binding]; metal-binding site
447217006721	TIGR00159 family protein; Region: TIGR00159
447217006722	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
447217006723	dihydropteroate synthase; Region: DHPS; TIGR01496
447217006724	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
447217006725	substrate binding pocket [chemical binding]; other site
447217006726	dimer interface [polypeptide binding]; other site
447217006727	inhibitor binding site; inhibition site
447217006728	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217006729	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217006730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006731	Walker A motif; other site
447217006732	ATP binding site [chemical binding]; other site
447217006733	Walker B motif; other site
447217006734	arginine finger; other site
447217006735	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217006736	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
447217006737	TilS substrate C-terminal domain; Region: TilS_C; smart00977
447217006738	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
447217006739	PilZ domain; Region: PilZ; pfam07238
447217006740	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217006741	IHF dimer interface [polypeptide binding]; other site
447217006742	IHF - DNA interface [nucleotide binding]; other site
447217006743	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
447217006744	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
447217006745	active site 2 [active]
447217006746	active site 1 [active]
447217006747	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217006748	B12 binding site [chemical binding]; other site
447217006749	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
447217006750	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
447217006751	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
447217006752	Ligand Binding Site [chemical binding]; other site
447217006753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006754	active site
447217006755	phosphorylation site [posttranslational modification]
447217006756	intermolecular recognition site; other site
447217006757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006758	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006759	dimer interface [polypeptide binding]; other site
447217006760	phosphorylation site [posttranslational modification]
447217006761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006762	ATP binding site [chemical binding]; other site
447217006763	Mg2+ binding site [ion binding]; other site
447217006764	G-X-G motif; other site
447217006765	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
447217006766	active site
447217006767	NTP binding site [chemical binding]; other site
447217006768	metal binding triad [ion binding]; metal-binding site
447217006769	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
447217006770	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
447217006771	Phage Tail Collar Domain; Region: Collar; pfam07484
447217006772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006773	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217006774	Walker A motif; other site
447217006775	ATP binding site [chemical binding]; other site
447217006776	Walker B motif; other site
447217006777	arginine finger; other site
447217006778	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217006779	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217006780	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217006781	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217006782	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217006783	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217006784	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217006785	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217006786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217006787	PAS fold; Region: PAS_4; pfam08448
447217006788	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006790	ATP binding site [chemical binding]; other site
447217006791	Mg2+ binding site [ion binding]; other site
447217006792	G-X-G motif; other site
447217006793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006794	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
447217006795	putative active site [active]
447217006796	heme pocket [chemical binding]; other site
447217006797	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217006798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006799	putative active site [active]
447217006800	heme pocket [chemical binding]; other site
447217006801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006802	dimer interface [polypeptide binding]; other site
447217006803	phosphorylation site [posttranslational modification]
447217006804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006805	ATP binding site [chemical binding]; other site
447217006806	Mg2+ binding site [ion binding]; other site
447217006807	G-X-G motif; other site
447217006808	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006810	active site
447217006811	phosphorylation site [posttranslational modification]
447217006812	intermolecular recognition site; other site
447217006813	dimerization interface [polypeptide binding]; other site
447217006814	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217006815	active site
447217006816	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217006817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217006818	YciI-like protein; Reviewed; Region: PRK12866
447217006819	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217006820	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217006821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217006822	dimerization interface [polypeptide binding]; other site
447217006823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217006824	S-adenosylmethionine binding site [chemical binding]; other site
447217006825	Cupin domain; Region: Cupin_2; cl17218
447217006826	Cupin domain; Region: Cupin_2; cl17218
447217006827	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
447217006828	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
447217006829	30S subunit binding site; other site
447217006830	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217006831	DNA-binding site [nucleotide binding]; DNA binding site
447217006832	RNA-binding motif; other site
447217006833	Uncharacterized conserved protein [Function unknown]; Region: COG2353
447217006834	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
447217006835	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
447217006836	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217006837	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217006838	active site
447217006839	metal binding site [ion binding]; metal-binding site
447217006840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006842	dimer interface [polypeptide binding]; other site
447217006843	phosphorylation site [posttranslational modification]
447217006844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006845	ATP binding site [chemical binding]; other site
447217006846	G-X-G motif; other site
447217006847	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217006848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006849	active site
447217006850	phosphorylation site [posttranslational modification]
447217006851	intermolecular recognition site; other site
447217006852	dimerization interface [polypeptide binding]; other site
447217006853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006854	Walker A motif; other site
447217006855	ATP binding site [chemical binding]; other site
447217006856	Walker B motif; other site
447217006857	arginine finger; other site
447217006858	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217006859	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006860	Ligand Binding Site [chemical binding]; other site
447217006861	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006862	Ligand Binding Site [chemical binding]; other site
447217006863	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006864	Ligand Binding Site [chemical binding]; other site
447217006865	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217006866	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217006867	DNA binding residues [nucleotide binding]
447217006868	dimerization interface [polypeptide binding]; other site
447217006869	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
447217006870	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
447217006871	Cl- selectivity filter; other site
447217006872	Cl- binding residues [ion binding]; other site
447217006873	pore gating glutamate residue; other site
447217006874	dimer interface [polypeptide binding]; other site
447217006875	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
447217006876	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217006877	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
447217006878	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217006879	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
447217006880	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
447217006881	active site
447217006882	homotetramer interface [polypeptide binding]; other site
447217006883	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
447217006884	putative active site [active]
447217006885	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
447217006886	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
447217006887	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
447217006888	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
447217006889	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
447217006890	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217006891	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217006892	acyl-activating enzyme (AAE) consensus motif; other site
447217006893	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
447217006894	acyl-activating enzyme (AAE) consensus motif; other site
447217006895	putative AMP binding site [chemical binding]; other site
447217006896	putative active site [active]
447217006897	putative CoA binding site [chemical binding]; other site
447217006898	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
447217006899	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
447217006900	active site
447217006901	catalytic residues [active]
447217006902	metal binding site [ion binding]; metal-binding site
447217006903	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217006904	EamA-like transporter family; Region: EamA; pfam00892
447217006905	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217006906	active site
447217006907	nucleophile elbow; other site
447217006908	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
447217006909	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217006910	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
447217006911	D-cysteine desulfhydrase; Validated; Region: PRK03910
447217006912	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
447217006913	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217006914	catalytic residue [active]
447217006915	FOG: WD40 repeat [General function prediction only]; Region: COG2319
447217006916	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217006917	DTW domain; Region: DTW; cl01221
447217006918	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
447217006919	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
447217006920	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
447217006921	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
447217006922	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
447217006923	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
447217006924	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
447217006925	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
447217006926	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
447217006927	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
447217006928	4Fe-4S binding domain; Region: Fer4; pfam00037
447217006929	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
447217006930	Cl- selectivity filter; other site
447217006931	Cl- binding residues [ion binding]; other site
447217006932	pore gating glutamate residue; other site
447217006933	dimer interface [polypeptide binding]; other site
447217006934	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217006935	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217006936	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
447217006937	Zn binding site [ion binding]; other site
447217006938	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
447217006939	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217006940	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
447217006941	putative NAD(P) binding site [chemical binding]; other site
447217006942	putative substrate binding site [chemical binding]; other site
447217006943	catalytic Zn binding site [ion binding]; other site
447217006944	structural Zn binding site [ion binding]; other site
447217006945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217006946	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217006947	active site
447217006948	oxidoreductase; Provisional; Region: PRK06196
447217006949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006950	NAD(P) binding site [chemical binding]; other site
447217006951	active site
447217006952	oxidoreductase; Provisional; Region: PRK06196
447217006953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006954	NAD(P) binding site [chemical binding]; other site
447217006955	active site
447217006956	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217006957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217006958	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217006959	active site
447217006960	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
447217006961	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
447217006962	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
447217006963	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
447217006964	MutS domain III; Region: MutS_III; pfam05192
447217006965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217006966	Walker A/P-loop; other site
447217006967	ATP binding site [chemical binding]; other site
447217006968	Q-loop/lid; other site
447217006969	ABC transporter signature motif; other site
447217006970	Walker B; other site
447217006971	D-loop; other site
447217006972	H-loop/switch region; other site
447217006973	methionine aminopeptidase; Provisional; Region: PRK12318
447217006974	SEC-C motif; Region: SEC-C; pfam02810
447217006975	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217006976	active site
447217006977	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
447217006978	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217006979	Hemerythrin-like domain; Region: Hr-like; cd12108
447217006980	Fe binding site [ion binding]; other site
447217006981	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217006982	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217006983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006984	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217006985	Walker A motif; other site
447217006986	ATP binding site [chemical binding]; other site
447217006987	Walker B motif; other site
447217006988	arginine finger; other site
447217006989	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
447217006990	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
447217006991	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
447217006992	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217006993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006994	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217006995	Walker A motif; other site
447217006996	ATP binding site [chemical binding]; other site
447217006997	Walker B motif; other site
447217006998	arginine finger; other site
447217006999	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217007000	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
447217007001	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
447217007002	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
447217007003	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
447217007004	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
447217007005	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
447217007006	FliG C-terminal domain; Region: FliG_C; pfam01706
447217007007	Flagellar assembly protein FliH; Region: FliH; pfam02108
447217007008	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
447217007009	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
447217007010	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217007011	Walker A motif; other site
447217007012	ATP binding site [chemical binding]; other site
447217007013	Walker B motif; other site
447217007014	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
447217007015	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
447217007016	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
447217007017	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
447217007018	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
447217007019	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
447217007020	Flagellar protein (FlbD); Region: FlbD; pfam06289
447217007021	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
447217007022	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217007023	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
447217007024	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
447217007025	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217007026	ligand binding site [chemical binding]; other site
447217007027	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217007028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007029	active site
447217007030	phosphorylation site [posttranslational modification]
447217007031	intermolecular recognition site; other site
447217007032	dimerization interface [polypeptide binding]; other site
447217007033	CheB methylesterase; Region: CheB_methylest; pfam01339
447217007034	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217007035	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217007036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217007037	S-adenosylmethionine binding site [chemical binding]; other site
447217007038	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217007039	putative CheA interaction surface; other site
447217007040	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217007041	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007042	dimerization interface [polypeptide binding]; other site
447217007043	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217007044	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217007045	dimer interface [polypeptide binding]; other site
447217007046	putative CheW interface [polypeptide binding]; other site
447217007047	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217007048	putative binding surface; other site
447217007049	active site
447217007050	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217007051	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217007052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007053	ATP binding site [chemical binding]; other site
447217007054	Mg2+ binding site [ion binding]; other site
447217007055	G-X-G motif; other site
447217007056	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217007057	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007059	active site
447217007060	phosphorylation site [posttranslational modification]
447217007061	intermolecular recognition site; other site
447217007062	dimerization interface [polypeptide binding]; other site
447217007063	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217007064	putative CheA interaction surface; other site
447217007065	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217007066	dimer interface [polypeptide binding]; other site
447217007067	putative CheW interface [polypeptide binding]; other site
447217007068	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217007069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007070	phosphorylation site [posttranslational modification]
447217007071	intermolecular recognition site; other site
447217007072	CheB methylesterase; Region: CheB_methylest; pfam01339
447217007073	CheD chemotactic sensory transduction; Region: CheD; cl00810
447217007074	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217007075	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217007076	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217007077	putative binding surface; other site
447217007078	active site
447217007079	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217007080	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217007081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007082	ATP binding site [chemical binding]; other site
447217007083	Mg2+ binding site [ion binding]; other site
447217007084	G-X-G motif; other site
447217007085	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217007086	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
447217007087	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007089	active site
447217007090	phosphorylation site [posttranslational modification]
447217007091	intermolecular recognition site; other site
447217007092	dimerization interface [polypeptide binding]; other site
447217007093	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007095	active site
447217007096	phosphorylation site [posttranslational modification]
447217007097	intermolecular recognition site; other site
447217007098	dimerization interface [polypeptide binding]; other site
447217007099	HDOD domain; Region: HDOD; pfam08668
447217007100	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217007101	Zn2+ binding site [ion binding]; other site
447217007102	Mg2+ binding site [ion binding]; other site
447217007103	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
447217007104	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
447217007105	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
447217007106	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
447217007107	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
447217007108	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
447217007109	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
447217007110	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
447217007111	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
447217007112	FHIPEP family; Region: FHIPEP; pfam00771
447217007113	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
447217007114	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
447217007115	FHIPEP family; Region: FHIPEP; pfam00771
447217007116	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
447217007117	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217007118	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
447217007119	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217007120	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
447217007121	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217007122	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
447217007123	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217007124	DNA binding residues [nucleotide binding]
447217007125	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
447217007126	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
447217007127	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
447217007128	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217007129	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
447217007130	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
447217007131	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
447217007132	Flagellar L-ring protein; Region: FlgH; pfam02107
447217007133	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
447217007134	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
447217007135	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
447217007136	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217007137	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217007138	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
447217007139	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
447217007140	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
447217007141	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
447217007142	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217007143	flagellin; Provisional; Region: PRK12802
447217007144	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217007145	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
447217007146	flagellar capping protein; Reviewed; Region: fliD; PRK08032
447217007147	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
447217007148	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
447217007149	flagellin; Provisional; Region: PRK12802
447217007150	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217007151	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
447217007152	Flagellar protein FliS; Region: FliS; cl00654
447217007153	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
447217007154	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
447217007155	putative metal binding site; other site
447217007156	PilZ domain; Region: PilZ; cl01260
447217007157	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
447217007158	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
447217007159	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217007160	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217007161	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
447217007162	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
447217007163	dimer interface [polypeptide binding]; other site
447217007164	putative functional site; other site
447217007165	putative MPT binding site; other site
447217007166	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
447217007167	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217007168	ligand binding site [chemical binding]; other site
447217007169	flexible hinge region; other site
447217007170	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
447217007171	DNA binding site [nucleotide binding]
447217007172	sequence specific DNA binding site [nucleotide binding]; other site
447217007173	putative cAMP binding site [chemical binding]; other site
447217007174	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
447217007175	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217007176	Ligand Binding Site [chemical binding]; other site
447217007177	FOG: CBS domain [General function prediction only]; Region: COG0517
447217007178	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803
447217007179	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
447217007180	heme-binding site [chemical binding]; other site
447217007181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217007182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007183	dimer interface [polypeptide binding]; other site
447217007184	phosphorylation site [posttranslational modification]
447217007185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007186	ATP binding site [chemical binding]; other site
447217007187	Mg2+ binding site [ion binding]; other site
447217007188	G-X-G motif; other site
447217007189	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217007190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007191	active site
447217007192	phosphorylation site [posttranslational modification]
447217007193	intermolecular recognition site; other site
447217007194	dimerization interface [polypeptide binding]; other site
447217007195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007196	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007197	active site
447217007198	phosphorylation site [posttranslational modification]
447217007199	intermolecular recognition site; other site
447217007200	dimerization interface [polypeptide binding]; other site
447217007201	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007203	active site
447217007204	phosphorylation site [posttranslational modification]
447217007205	intermolecular recognition site; other site
447217007206	dimerization interface [polypeptide binding]; other site
447217007207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007208	dimer interface [polypeptide binding]; other site
447217007209	phosphorylation site [posttranslational modification]
447217007210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007211	ATP binding site [chemical binding]; other site
447217007212	Mg2+ binding site [ion binding]; other site
447217007213	G-X-G motif; other site
447217007214	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217007215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007216	active site
447217007217	phosphorylation site [posttranslational modification]
447217007218	intermolecular recognition site; other site
447217007219	dimerization interface [polypeptide binding]; other site
447217007220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007221	Walker A motif; other site
447217007222	ATP binding site [chemical binding]; other site
447217007223	Walker B motif; other site
447217007224	arginine finger; other site
447217007225	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217007226	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
447217007227	radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X
447217007228	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
447217007229	FOG: CBS domain [General function prediction only]; Region: COG0517
447217007230	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217007231	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217007232	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217007233	Ligand Binding Site [chemical binding]; other site
447217007234	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
447217007235	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217007236	NAD binding site [chemical binding]; other site
447217007237	catalytic Zn binding site [ion binding]; other site
447217007238	structural Zn binding site [ion binding]; other site
447217007239	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
447217007240	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
447217007241	Isochorismatase family; Region: Isochorismatase; pfam00857
447217007242	catalytic triad [active]
447217007243	metal binding site [ion binding]; metal-binding site
447217007244	conserved cis-peptide bond; other site
447217007245	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
447217007246	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
447217007247	generic binding surface I; other site
447217007248	generic binding surface II; other site
447217007249	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217007250	Zn2+ binding site [ion binding]; other site
447217007251	Mg2+ binding site [ion binding]; other site
447217007252	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
447217007253	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
447217007254	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
447217007255	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
447217007256	active site
447217007257	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
447217007258	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
447217007259	active site
447217007260	HIGH motif; other site
447217007261	KMSKS motif; other site
447217007262	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
447217007263	anticodon binding site; other site
447217007264	tRNA binding surface [nucleotide binding]; other site
447217007265	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
447217007266	dimer interface [polypeptide binding]; other site
447217007267	putative tRNA-binding site [nucleotide binding]; other site
447217007268	DNA polymerase III, delta subunit; Region: holA; TIGR01128
447217007269	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
447217007270	DNA polymerase III subunit delta'; Validated; Region: PRK08485
447217007271	DivIVA protein; Region: DivIVA; pfam05103
447217007272	DNA polymerase I; Provisional; Region: PRK05755
447217007273	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
447217007274	active site
447217007275	metal binding site 1 [ion binding]; metal-binding site
447217007276	putative 5' ssDNA interaction site; other site
447217007277	metal binding site 3; metal-binding site
447217007278	metal binding site 2 [ion binding]; metal-binding site
447217007279	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
447217007280	putative DNA binding site [nucleotide binding]; other site
447217007281	putative metal binding site [ion binding]; other site
447217007282	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
447217007283	active site
447217007284	substrate binding site [chemical binding]; other site
447217007285	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
447217007286	active site
447217007287	DNA binding site [nucleotide binding]
447217007288	catalytic site [active]
447217007289	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217007290	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217007291	phosphopeptide binding site; other site
447217007292	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
447217007293	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
447217007294	dimer interface [polypeptide binding]; other site
447217007295	motif 1; other site
447217007296	active site
447217007297	motif 2; other site
447217007298	motif 3; other site
447217007299	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
447217007300	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
447217007301	putative substrate binding site [chemical binding]; other site
447217007302	putative ATP binding site [chemical binding]; other site
447217007303	Recombination protein O N terminal; Region: RecO_N; pfam11967
447217007304	DNA repair protein RecO; Region: reco; TIGR00613
447217007305	Recombination protein O C terminal; Region: RecO_C; pfam02565
447217007306	Helix-turn-helix domain; Region: HTH_25; pfam13413
447217007307	TPR repeat; Region: TPR_11; pfam13414
447217007308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007309	binding surface
447217007310	TPR motif; other site
447217007311	TPR repeat; Region: TPR_11; pfam13414
447217007312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007313	binding surface
447217007314	TPR motif; other site
447217007315	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
447217007316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217007317	FeS/SAM binding site; other site
447217007318	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
447217007319	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
447217007320	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217007321	catalytic residue [active]
447217007322	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
447217007323	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
447217007324	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
447217007325	quinone interaction residues [chemical binding]; other site
447217007326	active site
447217007327	catalytic residues [active]
447217007328	FMN binding site [chemical binding]; other site
447217007329	substrate binding site [chemical binding]; other site
447217007330	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
447217007331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217007332	Coenzyme A binding pocket [chemical binding]; other site
447217007333	chaperone protein DnaJ; Provisional; Region: PRK14299
447217007334	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217007335	HSP70 interaction site [polypeptide binding]; other site
447217007336	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
447217007337	substrate binding site [polypeptide binding]; other site
447217007338	dimer interface [polypeptide binding]; other site
447217007339	HEAT repeats; Region: HEAT_2; pfam13646
447217007340	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
447217007341	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
447217007342	putative acyl-acceptor binding pocket; other site
447217007343	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
447217007344	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
447217007345	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
447217007346	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
447217007347	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
447217007348	active site
447217007349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217007350	Coenzyme A binding pocket [chemical binding]; other site
447217007351	Ycf46; Provisional; Region: ycf46; CHL00195
447217007352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
447217007353	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217007354	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
447217007355	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217007356	Walker A motif; other site
447217007357	ATP binding site [chemical binding]; other site
447217007358	Walker B motif; other site
447217007359	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
447217007360	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
447217007361	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
447217007362	dimer interface [polypeptide binding]; other site
447217007363	substrate binding site [chemical binding]; other site
447217007364	metal binding sites [ion binding]; metal-binding site
447217007365	serine O-acetyltransferase; Region: cysE; TIGR01172
447217007366	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
447217007367	trimer interface [polypeptide binding]; other site
447217007368	active site
447217007369	substrate binding site [chemical binding]; other site
447217007370	CoA binding site [chemical binding]; other site
447217007371	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217007372	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217007373	dimer interface [polypeptide binding]; other site
447217007374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007375	catalytic residue [active]
447217007376	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
447217007377	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
447217007378	GIY-YIG motif/motif A; other site
447217007379	active site
447217007380	catalytic site [active]
447217007381	putative DNA binding site [nucleotide binding]; other site
447217007382	metal binding site [ion binding]; metal-binding site
447217007383	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
447217007384	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
447217007385	Cytochrome c; Region: Cytochrom_C; pfam00034
447217007386	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007387	dimerization interface [polypeptide binding]; other site
447217007388	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007389	dimer interface [polypeptide binding]; other site
447217007390	phosphorylation site [posttranslational modification]
447217007391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007392	ATP binding site [chemical binding]; other site
447217007393	Mg2+ binding site [ion binding]; other site
447217007394	G-X-G motif; other site
447217007395	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217007396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007397	active site
447217007398	phosphorylation site [posttranslational modification]
447217007399	intermolecular recognition site; other site
447217007400	dimerization interface [polypeptide binding]; other site
447217007401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007402	Walker A motif; other site
447217007403	ATP binding site [chemical binding]; other site
447217007404	Walker B motif; other site
447217007405	arginine finger; other site
447217007406	excinuclease ABC subunit B; Provisional; Region: PRK05298
447217007407	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217007408	ATP binding site [chemical binding]; other site
447217007409	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217007410	nucleotide binding region [chemical binding]; other site
447217007411	ATP-binding site [chemical binding]; other site
447217007412	Ultra-violet resistance protein B; Region: UvrB; pfam12344
447217007413	UvrB/uvrC motif; Region: UVR; pfam02151
447217007414	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217007415	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217007416	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217007417	DNA-binding site [nucleotide binding]; DNA binding site
447217007418	RNA-binding motif; other site
447217007419	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
447217007420	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
447217007421	active site
447217007422	HIGH motif; other site
447217007423	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
447217007424	KMSKS motif; other site
447217007425	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
447217007426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217007427	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
447217007428	active site
447217007429	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
447217007430	homotrimer interaction site [polypeptide binding]; other site
447217007431	zinc binding site [ion binding]; other site
447217007432	CDP-binding sites; other site
447217007433	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
447217007434	Competence protein; Region: Competence; cl00471
447217007435	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
447217007436	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217007437	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217007438	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217007439	phosphopeptide binding site; other site
447217007440	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
447217007441	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
447217007442	GDP-binding site [chemical binding]; other site
447217007443	ACT binding site; other site
447217007444	IMP binding site; other site
447217007445	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
447217007446	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
447217007447	dimer interface [polypeptide binding]; other site
447217007448	motif 1; other site
447217007449	motif 2; other site
447217007450	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217007451	active site
447217007452	motif 3; other site
447217007453	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
447217007454	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
447217007455	ligand binding site [chemical binding]; other site
447217007456	NAD binding site [chemical binding]; other site
447217007457	dimerization interface [polypeptide binding]; other site
447217007458	catalytic site [active]
447217007459	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
447217007460	putative L-serine binding site [chemical binding]; other site
447217007461	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217007462	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217007463	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
447217007464	AMIN domain; Region: AMIN; pfam11741
447217007465	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
447217007466	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217007467	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
447217007468	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
447217007469	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217007470	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
447217007471	ligand binding site [chemical binding]; other site
447217007472	flexible hinge region; other site
447217007473	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
447217007474	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
447217007475	dimerization interface [polypeptide binding]; other site
447217007476	putative ATP binding site [chemical binding]; other site
447217007477	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
447217007478	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
447217007479	active site
447217007480	substrate binding site [chemical binding]; other site
447217007481	cosubstrate binding site; other site
447217007482	catalytic site [active]
447217007483	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217007484	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
447217007485	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
447217007486	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
447217007487	putative active site [active]
447217007488	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
447217007489	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217007490	active site
447217007491	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14182
447217007492	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
447217007493	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
447217007494	homodimer interface [polypeptide binding]; other site
447217007495	NADP binding site [chemical binding]; other site
447217007496	substrate binding site [chemical binding]; other site
447217007497	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217007498	active site
447217007499	metal binding site [ion binding]; metal-binding site
447217007500	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
447217007501	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
447217007502	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217007503	lipoyl attachment site [posttranslational modification]; other site
447217007504	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
447217007505	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
447217007506	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007507	catalytic residue [active]
447217007508	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
447217007509	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007510	catalytic residue [active]
447217007511	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
447217007512	active site
447217007513	dimer interfaces [polypeptide binding]; other site
447217007514	catalytic residues [active]
447217007515	TonB C terminal; Region: TonB_2; pfam13103
447217007516	Transglycosylase; Region: Transgly; pfam00912
447217007517	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
447217007518	rRNA binding site [nucleotide binding]; other site
447217007519	predicted 30S ribosome binding site; other site
447217007520	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217007521	DNA-binding site [nucleotide binding]; DNA binding site
447217007522	RNA-binding motif; other site
447217007523	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
447217007524	YceG-like family; Region: YceG; pfam02618
447217007525	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
447217007526	dimerization interface [polypeptide binding]; other site
447217007527	PrkA AAA domain; Region: AAA_PrkA; smart00763
447217007528	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
447217007529	hypothetical protein; Provisional; Region: PRK05325
447217007530	SpoVR like protein; Region: SpoVR; pfam04293
447217007531	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
447217007532	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217007533	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217007534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007535	putative active site [active]
447217007536	heme pocket [chemical binding]; other site
447217007537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007538	helicase 45; Provisional; Region: PTZ00424
447217007539	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
447217007540	ATP binding site [chemical binding]; other site
447217007541	Mg++ binding site [ion binding]; other site
447217007542	motif III; other site
447217007543	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217007544	nucleotide binding region [chemical binding]; other site
447217007545	ATP-binding site [chemical binding]; other site
447217007546	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
447217007547	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217007548	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
447217007549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217007550	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
447217007551	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
447217007552	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217007553	metal ion-dependent adhesion site (MIDAS); other site
447217007554	CARDB; Region: CARDB; pfam07705
447217007555	Protein of unknown function (DUF1355); Region: DUF1355; pfam07090
447217007556	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
447217007557	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
447217007558	PEGA domain; Region: PEGA; pfam08308
447217007559	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
447217007560	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217007561	motif II; other site
447217007562	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
447217007563	classical (c) SDRs; Region: SDR_c; cd05233
447217007564	NAD(P) binding site [chemical binding]; other site
447217007565	active site
447217007566	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
447217007567	dimer interface [polypeptide binding]; other site
447217007568	[2Fe-2S] cluster binding site [ion binding]; other site
447217007569	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
447217007570	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
447217007571	Domain of unknown function (DU1801); Region: DUF1801; cl17490
447217007572	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
447217007573	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
447217007574	TPR repeat; Region: TPR_11; pfam13414
447217007575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007576	binding surface
447217007577	TPR motif; other site
447217007578	Domain of unknown function (DU1801); Region: DUF1801; cl17490
447217007579	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
447217007580	putative hydrophobic ligand binding site [chemical binding]; other site
447217007581	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217007582	dimerization interface [polypeptide binding]; other site
447217007583	putative DNA binding site [nucleotide binding]; other site
447217007584	putative Zn2+ binding site [ion binding]; other site
447217007585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217007586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217007587	TPR repeat; Region: TPR_11; pfam13414
447217007588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007589	short chain dehydrogenase; Provisional; Region: PRK07454
447217007590	NAD(P) binding site [chemical binding]; other site
447217007591	active site
447217007592	PAS domain S-box; Region: sensory_box; TIGR00229
447217007593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007594	putative active site [active]
447217007595	heme pocket [chemical binding]; other site
447217007596	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217007597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007598	ATP binding site [chemical binding]; other site
447217007599	Mg2+ binding site [ion binding]; other site
447217007600	G-X-G motif; other site
447217007601	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
447217007602	V-type ATP synthase subunit B; Provisional; Region: PRK04196
447217007603	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
447217007604	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
447217007605	Walker A motif homologous position; other site
447217007606	Walker B motif; other site
447217007607	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217007608	V-type ATP synthase subunit A; Provisional; Region: PRK04192
447217007609	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
447217007610	Walker A motif/ATP binding site; other site
447217007611	Walker B motif; other site
447217007612	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217007613	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
447217007614	V-type ATP synthase subunit I; Validated; Region: PRK05771
447217007615	V-type ATP synthase subunit I; Validated; Region: PRK05771
447217007616	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
447217007617	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217007618	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217007619	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217007620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007621	dimerization interface [polypeptide binding]; other site
447217007622	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217007623	dimer interface [polypeptide binding]; other site
447217007624	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
447217007625	putative CheW interface [polypeptide binding]; other site
447217007626	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217007627	putative binding surface; other site
447217007628	active site
447217007629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007630	ATP binding site [chemical binding]; other site
447217007631	Mg2+ binding site [ion binding]; other site
447217007632	G-X-G motif; other site
447217007633	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007635	active site
447217007636	phosphorylation site [posttranslational modification]
447217007637	intermolecular recognition site; other site
447217007638	dimerization interface [polypeptide binding]; other site
447217007639	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217007640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007641	active site
447217007642	phosphorylation site [posttranslational modification]
447217007643	intermolecular recognition site; other site
447217007644	CheB methylesterase; Region: CheB_methylest; pfam01339
447217007645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217007646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007647	dimer interface [polypeptide binding]; other site
447217007648	phosphorylation site [posttranslational modification]
447217007649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007650	ATP binding site [chemical binding]; other site
447217007651	Mg2+ binding site [ion binding]; other site
447217007652	G-X-G motif; other site
447217007653	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217007654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217007655	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217007656	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217007657	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
447217007658	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
447217007659	Outer membrane efflux protein; Region: OEP; pfam02321
447217007660	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217007661	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217007662	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217007663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217007664	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217007665	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
447217007666	nudix motif; other site
447217007667	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
447217007668	Fe-S cluster binding site [ion binding]; other site
447217007669	active site
447217007670	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
447217007671	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
447217007672	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
447217007673	catalytic site [active]
447217007674	G-X2-G-X-G-K; other site
447217007675	hypothetical protein; Provisional; Region: PRK11820
447217007676	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
447217007677	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
447217007678	Trm112p-like protein; Region: Trm112p; cl01066
447217007679	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217007680	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217007681	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
447217007682	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217007683	active site
447217007684	nucleotide binding site [chemical binding]; other site
447217007685	HIGH motif; other site
447217007686	KMSKS motif; other site
447217007687	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
447217007688	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
447217007689	putative ribose interaction site [chemical binding]; other site
447217007690	putative ADP binding site [chemical binding]; other site
447217007691	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
447217007692	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
447217007693	putative acyl-acceptor binding pocket; other site
447217007694	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
447217007695	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
447217007696	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
447217007697	putative active site [active]
447217007698	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
447217007699	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
447217007700	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217007701	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
447217007702	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
447217007703	active site
447217007704	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
447217007705	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
447217007706	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
447217007707	Walker A/P-loop; other site
447217007708	ATP binding site [chemical binding]; other site
447217007709	Q-loop/lid; other site
447217007710	ABC transporter signature motif; other site
447217007711	Walker B; other site
447217007712	D-loop; other site
447217007713	H-loop/switch region; other site
447217007714	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
447217007715	elongation factor G; Reviewed; Region: PRK12740
447217007716	G1 box; other site
447217007717	GTP/Mg2+ binding site [chemical binding]; other site
447217007718	G2 box; other site
447217007719	Switch I region; other site
447217007720	G3 box; other site
447217007721	Switch II region; other site
447217007722	G4 box; other site
447217007723	G5 box; other site
447217007724	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217007725	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217007726	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217007727	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
447217007728	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
447217007729	active site
447217007730	acyl-activating enzyme (AAE) consensus motif; other site
447217007731	putative CoA binding site [chemical binding]; other site
447217007732	AMP binding site [chemical binding]; other site
447217007733	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
447217007734	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
447217007735	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
447217007736	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
447217007737	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
447217007738	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007739	catalytic residue [active]
447217007740	MarC family integral membrane protein; Region: MarC; pfam01914
447217007741	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
447217007742	Ligand binding site; other site
447217007743	Putative Catalytic site; other site
447217007744	DXD motif; other site
447217007745	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
447217007746	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
447217007747	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217007748	dimerization interface [polypeptide binding]; other site
447217007749	putative DNA binding site [nucleotide binding]; other site
447217007750	putative Zn2+ binding site [ion binding]; other site
447217007751	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
447217007752	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
447217007753	4Fe-4S binding domain; Region: Fer4; pfam00037
447217007754	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217007755	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217007756	thiosulfate reductase PhsA; Provisional; Region: PRK15488
447217007757	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
447217007758	putative [Fe4-S4] binding site [ion binding]; other site
447217007759	putative molybdopterin cofactor binding site [chemical binding]; other site
447217007760	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
447217007761	molybdopterin cofactor binding site; other site
447217007762	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
447217007763	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217007764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007765	putative active site [active]
447217007766	heme pocket [chemical binding]; other site
447217007767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007768	dimer interface [polypeptide binding]; other site
447217007769	phosphorylation site [posttranslational modification]
447217007770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007771	ATP binding site [chemical binding]; other site
447217007772	Mg2+ binding site [ion binding]; other site
447217007773	G-X-G motif; other site
447217007774	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007776	active site
447217007777	phosphorylation site [posttranslational modification]
447217007778	intermolecular recognition site; other site
447217007779	dimerization interface [polypeptide binding]; other site
447217007780	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
447217007781	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
447217007782	putative Iron-sulfur protein interface [polypeptide binding]; other site
447217007783	proximal heme binding site [chemical binding]; other site
447217007784	distal heme binding site [chemical binding]; other site
447217007785	putative dimer interface [polypeptide binding]; other site
447217007786	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
447217007787	L-aspartate oxidase; Provisional; Region: PRK06175
447217007788	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217007789	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
447217007790	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
447217007791	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
447217007792	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217007793	putative ADP-binding pocket [chemical binding]; other site
447217007794	O-Antigen ligase; Region: Wzy_C; cl04850
447217007795	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
447217007796	putative homodimer interface [polypeptide binding]; other site
447217007797	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
447217007798	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007799	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007800	putative active site [active]
447217007801	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
447217007802	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
447217007803	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007804	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007805	catalytic residue [active]
447217007806	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007807	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
447217007808	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
447217007809	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
447217007810	phosphate binding site [ion binding]; other site
447217007811	putative substrate binding pocket [chemical binding]; other site
447217007812	dimer interface [polypeptide binding]; other site
447217007813	Bacterial sugar transferase; Region: Bac_transf; pfam02397
447217007814	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
447217007815	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
447217007816	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217007817	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
447217007818	SLBB domain; Region: SLBB; pfam10531
447217007819	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217007820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007821	active site
447217007822	phosphorylation site [posttranslational modification]
447217007823	intermolecular recognition site; other site
447217007824	dimerization interface [polypeptide binding]; other site
447217007825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007826	Walker A motif; other site
447217007827	ATP binding site [chemical binding]; other site
447217007828	Walker B motif; other site
447217007829	arginine finger; other site
447217007830	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217007831	active site residue [active]
447217007832	Stage II sporulation protein; Region: SpoIID; pfam08486
447217007833	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217007834	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
447217007835	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
447217007836	homodimer interface [polypeptide binding]; other site
447217007837	substrate-cofactor binding pocket; other site
447217007838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007839	catalytic residue [active]
447217007840	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217007841	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217007842	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217007843	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217007844	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217007845	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217007846	Walker A/P-loop; other site
447217007847	ATP binding site [chemical binding]; other site
447217007848	Q-loop/lid; other site
447217007849	ABC transporter signature motif; other site
447217007850	Walker B; other site
447217007851	D-loop; other site
447217007852	H-loop/switch region; other site
447217007853	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217007854	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217007855	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217007856	FtsX-like permease family; Region: FtsX; pfam02687
447217007857	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217007858	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217007859	short chain dehydrogenase; Provisional; Region: PRK07109
447217007860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007861	NAD(P) binding site [chemical binding]; other site
447217007862	active site
447217007863	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217007864	putative catalytic site [active]
447217007865	putative metal binding site [ion binding]; other site
447217007866	putative phosphate binding site [ion binding]; other site
447217007867	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
447217007868	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
447217007869	4Fe-4S binding domain; Region: Fer4; pfam00037
447217007870	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
447217007871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
447217007872	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217007873	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217007874	dimer interface [polypeptide binding]; other site
447217007875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007876	catalytic residue [active]
447217007877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217007878	S-adenosylmethionine binding site [chemical binding]; other site
447217007879	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
447217007880	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217007881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217007882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217007883	Low affinity iron permease; Region: Iron_permease; cl12096
447217007884	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
447217007885	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
447217007886	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217007887	Ligand Binding Site [chemical binding]; other site
447217007888	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
447217007889	FAD binding site [chemical binding]; other site
447217007890	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
447217007891	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217007892	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217007893	putative catalytic site [active]
447217007894	putative metal binding site [ion binding]; other site
447217007895	putative phosphate binding site [ion binding]; other site
447217007896	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
447217007897	G1 box; other site
447217007898	GTP/Mg2+ binding site [chemical binding]; other site
447217007899	Switch I region; other site
447217007900	G2 box; other site
447217007901	G3 box; other site
447217007902	Switch II region; other site
447217007903	G4 box; other site
447217007904	G5 box; other site
447217007905	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217007906	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
447217007907	dephospho-CoA kinase; Region: TIGR00152
447217007908	CoA-binding site [chemical binding]; other site
447217007909	ATP-binding [chemical binding]; other site
447217007910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007911	NAD(P) binding site [chemical binding]; other site
447217007912	active site
447217007913	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217007914	active site 2 [active]
447217007915	active site 1 [active]
447217007916	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
447217007917	active site
447217007918	catalytic site [active]
447217007919	TPR repeat; Region: TPR_11; pfam13414
447217007920	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
447217007921	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
447217007922	nucleotide binding site [chemical binding]; other site
447217007923	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
447217007924	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217007925	HSP70 interaction site [polypeptide binding]; other site
447217007926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217007927	ornithine carbamoyltransferase; Provisional; Region: PRK00779
447217007928	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
447217007929	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
447217007930	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
447217007931	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217007932	inhibitor-cofactor binding pocket; inhibition site
447217007933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007934	catalytic residue [active]
447217007935	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
447217007936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007937	Walker A motif; other site
447217007938	ATP binding site [chemical binding]; other site
447217007939	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
447217007940	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
447217007941	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
447217007942	active site
447217007943	HslU subunit interaction site [polypeptide binding]; other site
447217007944	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
447217007945	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
447217007946	active site
447217007947	DNA binding site [nucleotide binding]
447217007948	Int/Topo IB signature motif; other site
447217007949	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
447217007950	Glucose inhibited division protein A; Region: GIDA; pfam01134
447217007951	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
447217007952	DNA topoisomerase I; Validated; Region: PRK06599
447217007953	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
447217007954	active site
447217007955	interdomain interaction site; other site
447217007956	putative metal-binding site [ion binding]; other site
447217007957	nucleotide binding site [chemical binding]; other site
447217007958	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
447217007959	domain I; other site
447217007960	DNA binding groove [nucleotide binding]
447217007961	phosphate binding site [ion binding]; other site
447217007962	domain II; other site
447217007963	domain III; other site
447217007964	nucleotide binding site [chemical binding]; other site
447217007965	catalytic site [active]
447217007966	domain IV; other site
447217007967	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007968	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
447217007969	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007970	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007971	DNA protecting protein DprA; Region: dprA; TIGR00732
447217007972	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
447217007973	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217007974	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
447217007975	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
447217007976	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007977	dimerization interface [polypeptide binding]; other site
447217007978	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217007979	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217007980	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217007981	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217007982	metal binding site [ion binding]; metal-binding site
447217007983	active site
447217007984	I-site; other site
447217007985	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007987	active site
447217007988	phosphorylation site [posttranslational modification]
447217007989	intermolecular recognition site; other site
447217007990	dimerization interface [polypeptide binding]; other site
447217007991	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
447217007992	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
447217007993	active site
447217007994	metal binding site [ion binding]; metal-binding site
447217007995	MoxR-like ATPases [General function prediction only]; Region: COG0714
447217007996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007997	Walker A motif; other site
447217007998	ATP binding site [chemical binding]; other site
447217007999	Walker B motif; other site
447217008000	arginine finger; other site
447217008001	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
447217008002	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
447217008003	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217008004	putative ADP-binding pocket [chemical binding]; other site
447217008005	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217008006	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
447217008007	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
447217008008	catalytic residues [active]
447217008009	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
447217008010	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
447217008011	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217008012	Walker A motif; other site
447217008013	ATP binding site [chemical binding]; other site
447217008014	Walker B motif; other site
447217008015	PilZ domain; Region: PilZ; cl01260
447217008016	peptide chain release factor 2; Validated; Region: prfB; PRK00578
447217008017	This domain is found in peptide chain release factors; Region: PCRF; smart00937
447217008018	RF-1 domain; Region: RF-1; pfam00472
447217008019	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
447217008020	putative active site [active]
447217008021	catalytic triad [active]
447217008022	putative dimer interface [polypeptide binding]; other site
447217008023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217008024	Zn2+ binding site [ion binding]; other site
447217008025	Mg2+ binding site [ion binding]; other site
447217008026	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
447217008027	PhoH-like protein; Region: PhoH; pfam02562
447217008028	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217008029	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217008030	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
447217008031	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
447217008032	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
447217008033	homodimer interface [polypeptide binding]; other site
447217008034	metal binding site [ion binding]; metal-binding site
447217008035	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
447217008036	homodimer interface [polypeptide binding]; other site
447217008037	active site
447217008038	putative chemical substrate binding site [chemical binding]; other site
447217008039	metal binding site [ion binding]; metal-binding site
447217008040	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
447217008041	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
447217008042	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
447217008043	HIGH motif; other site
447217008044	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
447217008045	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217008046	active site
447217008047	KMSKS motif; other site
447217008048	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
447217008049	tRNA binding surface [nucleotide binding]; other site
447217008050	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
447217008051	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
447217008052	putative dimer interface [polypeptide binding]; other site
447217008053	putative anticodon binding site; other site
447217008054	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
447217008055	homodimer interface [polypeptide binding]; other site
447217008056	motif 1; other site
447217008057	motif 2; other site
447217008058	active site
447217008059	motif 3; other site
447217008060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008061	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008062	active site
447217008063	phosphorylation site [posttranslational modification]
447217008064	intermolecular recognition site; other site
447217008065	dimerization interface [polypeptide binding]; other site
447217008066	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
447217008067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008068	active site
447217008069	phosphorylation site [posttranslational modification]
447217008070	intermolecular recognition site; other site
447217008071	dimerization interface [polypeptide binding]; other site
447217008072	CheB methylesterase; Region: CheB_methylest; pfam01339
447217008073	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
447217008074	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217008075	HEAT repeats; Region: HEAT_2; pfam13646
447217008076	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
447217008077	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
447217008078	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
447217008079	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
447217008080	AAA domain; Region: AAA_30; pfam13604
447217008081	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217008082	putative binding surface; other site
447217008083	active site
447217008084	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217008085	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217008086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008087	ATP binding site [chemical binding]; other site
447217008088	Mg2+ binding site [ion binding]; other site
447217008089	G-X-G motif; other site
447217008090	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217008091	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
447217008092	putative RNA binding site [nucleotide binding]; other site
447217008093	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
447217008094	homopentamer interface [polypeptide binding]; other site
447217008095	active site
447217008096	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
447217008097	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
447217008098	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217008099	dimerization interface [polypeptide binding]; other site
447217008100	active site
447217008101	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
447217008102	Lumazine binding domain; Region: Lum_binding; pfam00677
447217008103	Lumazine binding domain; Region: Lum_binding; pfam00677
447217008104	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
447217008105	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
447217008106	catalytic motif [active]
447217008107	Zn binding site [ion binding]; other site
447217008108	RibD C-terminal domain; Region: RibD_C; cl17279
447217008109	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
447217008110	ATP cone domain; Region: ATP-cone; pfam03477
447217008111	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
447217008112	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
447217008113	dimer interface [polypeptide binding]; other site
447217008114	active site
447217008115	glycine-pyridoxal phosphate binding site [chemical binding]; other site
447217008116	folate binding site [chemical binding]; other site
447217008117	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
447217008118	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
447217008119	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
447217008120	dimer interface [polypeptide binding]; other site
447217008121	active site
447217008122	acyl carrier protein; Provisional; Region: acpP; PRK00982
447217008123	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217008124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008125	NAD(P) binding site [chemical binding]; other site
447217008126	active site
447217008127	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
447217008128	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
447217008129	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
447217008130	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
447217008131	dimer interface [polypeptide binding]; other site
447217008132	active site
447217008133	CoA binding pocket [chemical binding]; other site
447217008134	putative phosphate acyltransferase; Provisional; Region: PRK05331
447217008135	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
447217008136	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
447217008137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217008138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008139	active site
447217008140	phosphorylation site [posttranslational modification]
447217008141	intermolecular recognition site; other site
447217008142	dimerization interface [polypeptide binding]; other site
447217008143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217008144	DNA binding residues [nucleotide binding]
447217008145	dimerization interface [polypeptide binding]; other site
447217008146	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
447217008147	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
447217008148	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
447217008149	GIY-YIG motif/motif A; other site
447217008150	active site
447217008151	catalytic site [active]
447217008152	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
447217008153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008154	NAD(P) binding site [chemical binding]; other site
447217008155	active site
447217008156	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
447217008157	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217008158	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217008159	putative active site [active]
447217008160	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217008161	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217008162	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
447217008163	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217008164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008165	NAD(P) binding site [chemical binding]; other site
447217008166	active site
447217008167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008168	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
447217008169	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
447217008170	putative ADP-binding pocket [chemical binding]; other site
447217008171	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
447217008172	Bacterial sugar transferase; Region: Bac_transf; pfam02397
447217008173	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
447217008174	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217008175	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
447217008176	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
447217008177	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
447217008178	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
447217008179	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
447217008180	active site
447217008181	dimer interface [polypeptide binding]; other site
447217008182	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
447217008183	Ligand Binding Site [chemical binding]; other site
447217008184	Molecular Tunnel; other site
447217008185	NAD synthetase; Reviewed; Region: nadE; PRK00876
447217008186	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
447217008187	homodimer interface [polypeptide binding]; other site
447217008188	NAD binding pocket [chemical binding]; other site
447217008189	ATP binding pocket [chemical binding]; other site
447217008190	Mg binding site [ion binding]; other site
447217008191	active-site loop [active]
447217008192	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217008193	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217008194	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217008195	acyl-activating enzyme (AAE) consensus motif; other site
447217008196	AMP binding site [chemical binding]; other site
447217008197	active site
447217008198	CoA binding site [chemical binding]; other site
447217008199	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217008200	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217008201	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
447217008202	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
447217008203	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
447217008204	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
447217008205	trimer interface [polypeptide binding]; other site
447217008206	active site
447217008207	substrate binding site [chemical binding]; other site
447217008208	CoA binding site [chemical binding]; other site
447217008209	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217008210	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217008211	active site
447217008212	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
447217008213	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217008214	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
447217008215	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
447217008216	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
447217008217	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217008218	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
447217008219	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
447217008220	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
447217008221	Probable Catalytic site; other site
447217008222	metal-binding site
447217008223	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217008224	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
447217008225	Probable Catalytic site; other site
447217008226	metal-binding site
447217008227	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
447217008228	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
447217008229	Ligand Binding Site [chemical binding]; other site
447217008230	Molecular Tunnel; other site
447217008231	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217008232	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217008233	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
447217008234	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
447217008235	inhibitor-cofactor binding pocket; inhibition site
447217008236	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008237	catalytic residue [active]
447217008238	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
447217008239	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
447217008240	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
447217008241	Acyltransferase family; Region: Acyl_transf_3; pfam01757
447217008242	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
447217008243	putative ADP-binding pocket [chemical binding]; other site
447217008244	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217008245	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
447217008246	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
447217008247	FAD binding pocket [chemical binding]; other site
447217008248	FAD binding motif [chemical binding]; other site
447217008249	phosphate binding motif [ion binding]; other site
447217008250	beta-alpha-beta structure motif; other site
447217008251	NAD binding pocket [chemical binding]; other site
447217008252	Iron coordination center [ion binding]; other site
447217008253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
447217008254	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217008255	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
447217008256	diiron binding motif [ion binding]; other site
447217008257	PilZ domain; Region: PilZ; pfam07238
447217008258	Rhomboid family; Region: Rhomboid; pfam01694
447217008259	RNA polymerase sigma factor; Provisional; Region: PRK12518
447217008260	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217008261	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217008262	active site
447217008263	ATP binding site [chemical binding]; other site
447217008264	substrate binding site [chemical binding]; other site
447217008265	activation loop (A-loop); other site
447217008266	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
447217008267	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008268	putative NAD(P) binding site [chemical binding]; other site
447217008269	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
447217008270	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
447217008271	cofactor binding site; other site
447217008272	metal binding site [ion binding]; metal-binding site
447217008273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217008274	ABC transporter; Region: ABC_tran; pfam00005
447217008275	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217008276	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217008277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008278	active site
447217008279	phosphorylation site [posttranslational modification]
447217008280	intermolecular recognition site; other site
447217008281	dimerization interface [polypeptide binding]; other site
447217008282	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
447217008283	Na binding site [ion binding]; other site
447217008284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217008285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008286	dimer interface [polypeptide binding]; other site
447217008287	phosphorylation site [posttranslational modification]
447217008288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008289	ATP binding site [chemical binding]; other site
447217008290	Mg2+ binding site [ion binding]; other site
447217008291	G-X-G motif; other site
447217008292	Uncharacterized conserved protein [Function unknown]; Region: COG4198
447217008293	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
447217008294	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
447217008295	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
447217008296	Uncharacterized conserved protein [Function unknown]; Region: COG1432
447217008297	NYN domain; Region: NYN; pfam01936
447217008298	putative metal binding site [ion binding]; other site
447217008299	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
447217008300	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
447217008301	short chain dehydrogenase; Provisional; Region: PRK06701
447217008302	NAD binding site [chemical binding]; other site
447217008303	metal binding site [ion binding]; metal-binding site
447217008304	active site
447217008305	TPR repeat; Region: TPR_11; pfam13414
447217008306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008307	binding surface
447217008308	TPR motif; other site
447217008309	TPR repeat; Region: TPR_11; pfam13414
447217008310	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008311	binding surface
447217008312	TPR motif; other site
447217008313	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
447217008314	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217008315	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
447217008316	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
447217008317	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
447217008318	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
447217008319	Walker A motif; other site
447217008320	hexamer interface [polypeptide binding]; other site
447217008321	ATP binding site [chemical binding]; other site
447217008322	Walker B motif; other site
447217008323	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
447217008324	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
447217008325	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
447217008326	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
447217008327	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
447217008328	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217008329	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
447217008330	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
447217008331	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
447217008332	TadE-like protein; Region: TadE; pfam07811
447217008333	Flp/Fap pilin component; Region: Flp_Fap; cl01585
447217008334	Phospholipid methyltransferase; Region: PEMT; cl17370
447217008335	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
447217008336	active site
447217008337	catalytic site [active]
447217008338	substrate binding site [chemical binding]; other site
447217008339	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
447217008340	DNA topoisomerase VI subunit A; Provisional; Region: PRK04342
447217008341	Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406
447217008342	TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223
447217008343	active site
447217008344	metal binding site [ion binding]; metal-binding site
447217008345	interdomain interaction site; other site
447217008346	DNA topoisomerase VI subunit B; Validated; Region: PRK04184
447217008347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008348	ATP binding site [chemical binding]; other site
447217008349	Mg2+ binding site [ion binding]; other site
447217008350	G-X-G motif; other site
447217008351	TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823
447217008352	anchoring element; other site
447217008353	dimer interface [polypeptide binding]; other site
447217008354	ATP binding site [chemical binding]; other site
447217008355	Peptidase family M48; Region: Peptidase_M48; cl12018
447217008356	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008357	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
447217008358	putative NAD(P) binding site [chemical binding]; other site
447217008359	structural Zn binding site [ion binding]; other site
447217008360	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217008361	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
447217008362	catalytic triad [active]
447217008363	Transposase domain (DUF772); Region: DUF772; pfam05598
447217008364	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217008365	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217008366	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
447217008367	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
447217008368	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
447217008369	EamA-like transporter family; Region: EamA; pfam00892
447217008370	epoxyqueuosine reductase; Region: TIGR00276
447217008371	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
447217008372	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
447217008373	DNA methylase; Region: N6_N4_Mtase; cl17433
447217008374	DNA methylase; Region: N6_N4_Mtase; pfam01555
447217008375	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
447217008376	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
447217008377	active site
447217008378	Zn binding site [ion binding]; other site
447217008379	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
447217008380	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
447217008381	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
447217008382	nickel binding site [ion binding]; other site
447217008383	Flagellin N-methylase; Region: FliB; pfam03692
447217008384	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
447217008385	Cysteine-rich domain; Region: CCG; pfam02754
447217008386	Cysteine-rich domain; Region: CCG; pfam02754
447217008387	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008388	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217008389	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008390	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
447217008391	classical (c) SDRs; Region: SDR_c; cd05233
447217008392	short chain dehydrogenase; Provisional; Region: PRK07041
447217008393	NAD(P) binding site [chemical binding]; other site
447217008394	active site
447217008395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008396	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217008397	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273
447217008398	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008399	putative NAD(P) binding site [chemical binding]; other site
447217008400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
447217008401	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
447217008402	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008403	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217008404	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
447217008405	rRNA binding site [nucleotide binding]; other site
447217008406	predicted 30S ribosome binding site; other site
447217008407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217008408	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
447217008409	homotrimer interaction site [polypeptide binding]; other site
447217008410	putative active site [active]
447217008411	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
447217008412	DNA binding site [nucleotide binding]
447217008413	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
447217008414	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217008415	Methyltransferase domain; Region: Methyltransf_23; pfam13489
447217008416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008417	S-adenosylmethionine binding site [chemical binding]; other site
447217008418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217008419	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217008420	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217008421	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217008422	active site
447217008423	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217008424	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
447217008425	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
447217008426	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
447217008427	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
447217008428	catalytic core [active]
447217008429	Cupin domain; Region: Cupin_2; cl17218
447217008430	phosphate acetyltransferase; Reviewed; Region: PRK05632
447217008431	DRTGG domain; Region: DRTGG; pfam07085
447217008432	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
447217008433	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
447217008434	propionate/acetate kinase; Provisional; Region: PRK12379
447217008435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008436	NADH(P)-binding; Region: NAD_binding_10; pfam13460
447217008437	NAD(P) binding site [chemical binding]; other site
447217008438	active site
447217008439	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217008440	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217008441	Cytochrome c552; Region: Cytochrom_C552; pfam02335
447217008442	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217008443	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
447217008444	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217008445	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217008446	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217008447	acyl-activating enzyme (AAE) consensus motif; other site
447217008448	AMP binding site [chemical binding]; other site
447217008449	active site
447217008450	CoA binding site [chemical binding]; other site
447217008451	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
447217008452	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
447217008453	active site
447217008454	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
447217008455	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217008456	active site
447217008457	catalytic site [active]
447217008458	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217008459	Protein of unknown function, DUF488; Region: DUF488; cl01246
447217008460	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217008461	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
447217008462	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
447217008463	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
447217008464	dimer interface [polypeptide binding]; other site
447217008465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217008466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008467	active site
447217008468	phosphorylation site [posttranslational modification]
447217008469	intermolecular recognition site; other site
447217008470	dimerization interface [polypeptide binding]; other site
447217008471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217008472	DNA binding site [nucleotide binding]
447217008473	HAMP domain; Region: HAMP; pfam00672
447217008474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217008475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008476	dimer interface [polypeptide binding]; other site
447217008477	phosphorylation site [posttranslational modification]
447217008478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008479	ATP binding site [chemical binding]; other site
447217008480	G-X-G motif; other site
447217008481	Spherulation-specific family 4; Region: Spherulin4; pfam12138
447217008482	MarR family; Region: MarR_2; pfam12802
447217008483	Amidase; Region: Amidase; cl11426
447217008484	Amidase; Region: Amidase; cl11426
447217008485	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008486	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217008487	poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940
447217008488	N-glycosyltransferase; Provisional; Region: PRK11204
447217008489	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
447217008490	DXD motif; other site
447217008491	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
447217008492	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
447217008493	putative active site [active]
447217008494	putative metal binding site [ion binding]; other site
447217008495	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217008496	Peptidase family M48; Region: Peptidase_M48; cl12018
447217008497	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
447217008498	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
447217008499	ATP binding site [chemical binding]; other site
447217008500	substrate interface [chemical binding]; other site
447217008501	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
447217008502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008503	Walker A motif; other site
447217008504	ATP binding site [chemical binding]; other site
447217008505	Walker B motif; other site
447217008506	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
447217008507	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
447217008508	4Fe-4S binding domain; Region: Fer4; pfam00037
447217008509	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
447217008510	L-aspartate oxidase; Provisional; Region: PRK06175
447217008511	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217008512	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
447217008513	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
447217008514	putative Iron-sulfur protein interface [polypeptide binding]; other site
447217008515	proximal heme binding site [chemical binding]; other site
447217008516	distal heme binding site [chemical binding]; other site
447217008517	putative dimer interface [polypeptide binding]; other site
447217008518	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217008519	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
447217008520	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
447217008521	PA/protease or protease-like domain interface [polypeptide binding]; other site
447217008522	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
447217008523	Zn binding site [ion binding]; other site
447217008524	PEGA domain; Region: PEGA; pfam08308
447217008525	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217008526	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217008527	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
447217008528	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
447217008529	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217008530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217008531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008532	dimer interface [polypeptide binding]; other site
447217008533	phosphorylation site [posttranslational modification]
447217008534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008535	ATP binding site [chemical binding]; other site
447217008536	Mg2+ binding site [ion binding]; other site
447217008537	G-X-G motif; other site
447217008538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008539	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008540	active site
447217008541	phosphorylation site [posttranslational modification]
447217008542	intermolecular recognition site; other site
447217008543	dimerization interface [polypeptide binding]; other site
447217008544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217008545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008546	dimer interface [polypeptide binding]; other site
447217008547	phosphorylation site [posttranslational modification]
447217008548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008549	ATP binding site [chemical binding]; other site
447217008550	Mg2+ binding site [ion binding]; other site
447217008551	G-X-G motif; other site
447217008552	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008554	active site
447217008555	phosphorylation site [posttranslational modification]
447217008556	intermolecular recognition site; other site
447217008557	dimerization interface [polypeptide binding]; other site
447217008558	circadian clock protein KaiC; Reviewed; Region: PRK09302
447217008559	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217008560	Walker A motif; other site
447217008561	ATP binding site [chemical binding]; other site
447217008562	Walker B motif; other site
447217008563	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217008564	Walker A motif; other site
447217008565	ATP binding site [chemical binding]; other site
447217008566	Walker B motif; other site
447217008567	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
447217008568	putative hydrophobic ligand binding site [chemical binding]; other site
447217008569	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
447217008570	active site
447217008571	catalytic residues [active]
447217008572	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
447217008573	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
447217008574	active site
447217008575	DNA binding site [nucleotide binding]
447217008576	Int/Topo IB signature motif; other site
447217008577	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217008578	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217008579	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
447217008580	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
447217008581	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
447217008582	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217008583	ATP binding site [chemical binding]; other site
447217008584	Mg++ binding site [ion binding]; other site
447217008585	motif III; other site
447217008586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217008587	nucleotide binding region [chemical binding]; other site
447217008588	ATP-binding site [chemical binding]; other site
447217008589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217008590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008591	dimer interface [polypeptide binding]; other site
447217008592	phosphorylation site [posttranslational modification]
447217008593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008594	ATP binding site [chemical binding]; other site
447217008595	Mg2+ binding site [ion binding]; other site
447217008596	G-X-G motif; other site
447217008597	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217008598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008599	active site
447217008600	phosphorylation site [posttranslational modification]
447217008601	intermolecular recognition site; other site
447217008602	dimerization interface [polypeptide binding]; other site
447217008603	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
447217008604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217008605	putative substrate translocation pore; other site
447217008606	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
447217008607	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
447217008608	putative ligand binding site [chemical binding]; other site
447217008609	putative NAD binding site [chemical binding]; other site
447217008610	putative catalytic site [active]
447217008611	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
447217008612	L-serine binding site [chemical binding]; other site
447217008613	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
447217008614	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008615	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
447217008616	Nudix hydrolase homolog; Region: PLN02791
447217008617	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
447217008618	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
447217008619	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217008620	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
447217008621	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217008622	carboxyltransferase (CT) interaction site; other site
447217008623	biotinylation site [posttranslational modification]; other site
447217008624	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
447217008625	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217008626	Outer membrane efflux protein; Region: OEP; pfam02321
447217008627	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217008628	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217008629	FtsX-like permease family; Region: FtsX; pfam02687
447217008630	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217008631	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217008632	Walker A/P-loop; other site
447217008633	ATP binding site [chemical binding]; other site
447217008634	Q-loop/lid; other site
447217008635	ABC transporter signature motif; other site
447217008636	Walker B; other site
447217008637	D-loop; other site
447217008638	H-loop/switch region; other site
447217008639	macrolide transporter subunit MacA; Provisional; Region: PRK11578
447217008640	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217008641	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217008642	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
447217008643	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
447217008644	Histidine kinase; Region: His_kinase; pfam06580
447217008645	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
447217008646	ATP binding site [chemical binding]; other site
447217008647	Mg2+ binding site [ion binding]; other site
447217008648	G-X-G motif; other site
447217008649	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
447217008650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008651	active site
447217008652	phosphorylation site [posttranslational modification]
447217008653	intermolecular recognition site; other site
447217008654	dimerization interface [polypeptide binding]; other site
447217008655	LytTr DNA-binding domain; Region: LytTR; smart00850
447217008656	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217008657	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008658	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
447217008659	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217008660	L-lactate permease; Region: Lactate_perm; cl00701
447217008661	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
447217008662	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217008663	Cysteine-rich domain; Region: CCG; pfam02754
447217008664	Cysteine-rich domain; Region: CCG; pfam02754
447217008665	iron-sulfur cluster-binding protein; Region: TIGR00273
447217008666	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
447217008667	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
447217008668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217008669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008670	S-adenosylmethionine binding site [chemical binding]; other site
447217008671	TPR repeat; Region: TPR_11; pfam13414
447217008672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008673	binding surface
447217008674	TPR motif; other site
447217008675	Protein of unknown function, DUF399; Region: DUF399; pfam04187
447217008676	multiple promoter invertase; Provisional; Region: mpi; PRK13413
447217008677	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
447217008678	catalytic residues [active]
447217008679	catalytic nucleophile [active]
447217008680	Presynaptic Site I dimer interface [polypeptide binding]; other site
447217008681	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
447217008682	Synaptic Flat tetramer interface [polypeptide binding]; other site
447217008683	Synaptic Site I dimer interface [polypeptide binding]; other site
447217008684	DNA binding site [nucleotide binding]
447217008685	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
447217008686	DNA-binding interface [nucleotide binding]; DNA binding site
447217008687	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217008688	PilZ domain; Region: PilZ; pfam07238
447217008689	Predicted methyltransferase [General function prediction only]; Region: COG3897
447217008690	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217008691	Uncharacterized conserved protein [Function unknown]; Region: COG3268
447217008692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008693	NAD(P) binding site [chemical binding]; other site
447217008694	active site
447217008695	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
447217008696	UPF0126 domain; Region: UPF0126; pfam03458
447217008697	Predicted membrane protein [Function unknown]; Region: COG2860
447217008698	UPF0126 domain; Region: UPF0126; pfam03458
447217008699	Predicted membrane protein [Function unknown]; Region: COG2246
447217008700	GtrA-like protein; Region: GtrA; pfam04138
447217008701	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
447217008702	Methyltransferase domain; Region: Methyltransf_31; pfam13847
447217008703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008704	S-adenosylmethionine binding site [chemical binding]; other site
447217008705	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
447217008706	homodimer interface [polypeptide binding]; other site
447217008707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008708	catalytic residue [active]
447217008709	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008711	active site
447217008712	phosphorylation site [posttranslational modification]
447217008713	intermolecular recognition site; other site
447217008714	dimerization interface [polypeptide binding]; other site
447217008715	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217008716	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217008717	non-specific DNA binding site [nucleotide binding]; other site
447217008718	salt bridge; other site
447217008719	sequence-specific DNA binding site [nucleotide binding]; other site
447217008720	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
447217008721	Domain of unknown function (DUF955); Region: DUF955; pfam06114
447217008722	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
447217008723	malate synthase A; Region: malate_syn_A; TIGR01344
447217008724	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
447217008725	active site
447217008726	isocitrate lyase; Provisional; Region: PRK15063
447217008727	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217008728	tetramer interface [polypeptide binding]; other site
447217008729	active site
447217008730	Mg2+/Mn2+ binding site [ion binding]; other site
447217008731	Hemerythrin-like domain; Region: Hr-like; cd12108
447217008732	4-alpha-glucanotransferase; Provisional; Region: PRK14508
447217008733	trehalose synthase; Region: treS_nterm; TIGR02456
447217008734	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
447217008735	active site
447217008736	catalytic site [active]
447217008737	FOG: CBS domain [General function prediction only]; Region: COG0517
447217008738	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
447217008739	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
447217008740	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
447217008741	ligand binding site [chemical binding]; other site
447217008742	homodimer interface [polypeptide binding]; other site
447217008743	NAD(P) binding site [chemical binding]; other site
447217008744	trimer interface B [polypeptide binding]; other site
447217008745	trimer interface A [polypeptide binding]; other site
447217008746	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
447217008747	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
447217008748	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
447217008749	AMP-binding domain protein; Validated; Region: PRK08315
447217008750	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
447217008751	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
447217008752	acyl-activating enzyme (AAE) consensus motif; other site
447217008753	acyl-activating enzyme (AAE) consensus motif; other site
447217008754	putative AMP binding site [chemical binding]; other site
447217008755	putative active site [active]
447217008756	putative CoA binding site [chemical binding]; other site
447217008757	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008758	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
447217008759	NADP binding site [chemical binding]; other site
447217008760	dimer interface [polypeptide binding]; other site
447217008761	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
447217008762	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217008763	TPP-binding site [chemical binding]; other site
447217008764	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
447217008765	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
447217008766	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
447217008767	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217008768	dimer interface [polypeptide binding]; other site
447217008769	PYR/PP interface [polypeptide binding]; other site
447217008770	TPP binding site [chemical binding]; other site
447217008771	substrate binding site [chemical binding]; other site
447217008772	pyruvate carboxylase; Reviewed; Region: PRK12999
447217008773	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217008774	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217008775	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
447217008776	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
447217008777	active site
447217008778	catalytic residues [active]
447217008779	metal binding site [ion binding]; metal-binding site
447217008780	homodimer binding site [polypeptide binding]; other site
447217008781	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217008782	carboxyltransferase (CT) interaction site; other site
447217008783	biotinylation site [posttranslational modification]; other site
447217008784	Hemerythrin; Region: Hemerythrin; cd12107
447217008785	Fe binding site [ion binding]; other site
447217008786	Hemerythrin; Region: Hemerythrin; cd12107
447217008787	Fe binding site [ion binding]; other site
447217008788	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
447217008789	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217008790	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008791	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
447217008792	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217008793	Cysteine-rich domain; Region: CCG; pfam02754
447217008794	glutamate dehydrogenase; Provisional; Region: PRK09414
447217008795	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
447217008796	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
447217008797	NAD(P) binding site [chemical binding]; other site
447217008798	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217008799	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217008800	active site
447217008801	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217008802	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217008803	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217008804	active site
447217008805	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
447217008806	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
447217008807	NAD(P) binding site [chemical binding]; other site
447217008808	catalytic residues [active]
447217008809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008810	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217008811	NAD(P) binding site [chemical binding]; other site
447217008812	active site
447217008813	photolyase PhrII; Region: phr2; TIGR00591
447217008814	DNA photolyase; Region: DNA_photolyase; pfam00875
447217008815	Protein of unknown function (DUF523); Region: DUF523; pfam04463
447217008816	Uncharacterized conserved protein [Function unknown]; Region: COG3272
447217008817	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
447217008818	Predicted membrane protein [Function unknown]; Region: COG3671
447217008819	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
447217008820	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
447217008821	nucleotide binding site [chemical binding]; other site
447217008822	putative NEF/HSP70 interaction site [polypeptide binding]; other site
447217008823	SBD interface [polypeptide binding]; other site
447217008824	DNA-K related protein; Region: DUF3731; pfam12531
447217008825	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
447217008826	nucleotide binding site [chemical binding]; other site
447217008827	putative NEF/HSP70 interaction site [polypeptide binding]; other site
447217008828	SBD interface [polypeptide binding]; other site
447217008829	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
447217008830	Protein of unknown function DUF72; Region: DUF72; pfam01904
447217008831	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008832	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217008833	active site
447217008834	catalytic tetrad [active]
447217008835	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
447217008836	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
447217008837	active site
447217008838	catalytic residues [active]
447217008839	metal binding site [ion binding]; metal-binding site
447217008840	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008841	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217008842	active site
447217008843	catalytic tetrad [active]
447217008844	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
447217008845	intracellular protease, PfpI family; Region: PfpI; TIGR01382
447217008846	proposed catalytic triad [active]
447217008847	conserved cys residue [active]
447217008848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008849	S-adenosylmethionine binding site [chemical binding]; other site
447217008850	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
447217008851	helicase 45; Provisional; Region: PTZ00424
447217008852	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
447217008853	ATP binding site [chemical binding]; other site
447217008854	putative Mg++ binding site [ion binding]; other site
447217008855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217008856	nucleotide binding region [chemical binding]; other site
447217008857	ATP-binding site [chemical binding]; other site
447217008858	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
447217008859	RNA binding site [nucleotide binding]; other site
447217008860	Hemerythrin-like domain of FBXL5-like proteins; Region: Hr_FBXL5; cd12109
447217008861	Fe binding site [ion binding]; other site
447217008862	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
447217008863	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217008864	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217008865	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
447217008866	putative deacylase active site [active]
447217008867	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217008868	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217008869	metal-binding site
447217008870	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
447217008871	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
447217008872	Ligand binding site; other site
447217008873	Putative Catalytic site; other site
447217008874	DXD motif; other site
447217008875	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217008876	active site
447217008877	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217008878	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217008879	Methyltransferase domain; Region: Methyltransf_23; pfam13489
447217008880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008881	S-adenosylmethionine binding site [chemical binding]; other site
447217008882	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
447217008883	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
447217008884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217008885	Coenzyme A binding pocket [chemical binding]; other site
447217008886	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
447217008887	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
447217008888	inhibitor-cofactor binding pocket; inhibition site
447217008889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008890	catalytic residue [active]
447217008891	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
447217008892	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217008893	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
447217008894	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217008895	metal-binding site
447217008896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217008897	ZU5 domain; Region: ZU5; cl02517
447217008898	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
447217008899	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
447217008900	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
447217008901	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
447217008902	NHL repeat; Region: NHL; pfam01436
447217008903	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008904	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008905	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008906	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008907	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008908	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008909	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008910	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008911	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008912	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008913	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008914	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008915	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008916	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008917	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008918	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008919	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008920	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008921	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008922	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008923	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008924	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217008925	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
447217008926	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
447217008927	Uncharacterized conserved protein [Function unknown]; Region: COG3391
447217008928	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008929	binding surface
447217008930	TPR motif; other site
447217008931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008932	binding surface
447217008933	TPR motif; other site
447217008934	chaperone protein DnaJ; Provisional; Region: PRK14276
447217008935	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
447217008936	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
447217008937	active site
447217008938	dimer interface [polypeptide binding]; other site
447217008939	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
447217008940	dimer interface [polypeptide binding]; other site
447217008941	active site
447217008942	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
447217008943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
447217008944	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
447217008945	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
447217008946	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217008947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008948	homodimer interface [polypeptide binding]; other site
447217008949	catalytic residue [active]
447217008950	argininosuccinate synthase; Validated; Region: PRK05370
447217008951	argininosuccinate synthase; Provisional; Region: PRK13820
447217008952	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217008953	4Fe-4S binding domain; Region: Fer4; cl02805
447217008954	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
447217008955	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
447217008956	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
447217008957	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217008958	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217008959	PAS fold; Region: PAS; pfam00989
447217008960	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217008961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008962	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217008963	Walker A motif; other site
447217008964	ATP binding site [chemical binding]; other site
447217008965	Walker B motif; other site
447217008966	arginine finger; other site
447217008967	Rubrerythrin [Energy production and conversion]; Region: COG1592
447217008968	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217008969	binuclear metal center [ion binding]; other site
447217008970	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
447217008971	iron binding site [ion binding]; other site
447217008972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217008973	dimerization interface [polypeptide binding]; other site
447217008974	putative DNA binding site [nucleotide binding]; other site
447217008975	putative Zn2+ binding site [ion binding]; other site
447217008976	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217008977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008978	NAD(P) binding site [chemical binding]; other site
447217008979	active site
447217008980	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008981	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217008982	active site
447217008983	catalytic tetrad [active]
447217008984	deoxyhypusine synthase; Region: dhys; TIGR00321
447217008985	Deoxyhypusine synthase; Region: DS; cl00826
447217008986	Deoxyhypusine synthase; Region: DS; cl00826
447217008987	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217008988	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
447217008989	Zn binding site [ion binding]; other site
447217008990	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008991	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217008992	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217008993	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217008994	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217008995	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
447217008996	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217008997	FeS/SAM binding site; other site
447217008998	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
447217008999	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
447217009000	nitrogenase iron protein; Region: nifH; TIGR01287
447217009001	Nucleotide-binding sites [chemical binding]; other site
447217009002	Walker A motif; other site
447217009003	Switch I region of nucleotide binding site; other site
447217009004	Fe4S4 binding sites [ion binding]; other site
447217009005	Switch II region of nucleotide binding site; other site
447217009006	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
447217009007	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
447217009008	MoFe protein alpha/beta subunit interactions; other site
447217009009	Alpha subunit P cluster binding residues; other site
447217009010	FeMoco binding residues [chemical binding]; other site
447217009011	MoFe protein alpha subunit/Fe protein contacts; other site
447217009012	MoFe protein dimer/ dimer interactions; other site
447217009013	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
447217009014	MoFe protein beta/alpha subunit interactions; other site
447217009015	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
447217009016	Beta subunit P cluster binding residues; other site
447217009017	MoFe protein beta subunit/Fe protein contacts; other site
447217009018	MoFe protein dimer/ dimer interactions; other site
447217009019	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
447217009020	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
447217009021	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
447217009022	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
447217009023	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
447217009024	4Fe-4S binding domain; Region: Fer4; cl02805
447217009025	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
447217009026	Nif-specific regulatory protein; Region: nifA; TIGR01817
447217009027	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217009028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009029	Walker A motif; other site
447217009030	ATP binding site [chemical binding]; other site
447217009031	Walker B motif; other site
447217009032	arginine finger; other site
447217009033	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217009034	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
447217009035	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217009036	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
447217009037	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217009038	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217009039	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
447217009040	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217009041	catalytic loop [active]
447217009042	iron binding site [ion binding]; other site
447217009043	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
447217009044	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
447217009045	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
447217009046	XdhC Rossmann domain; Region: XdhC_C; pfam13478
447217009047	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217009048	active site
447217009049	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
447217009050	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
447217009051	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
447217009052	active site
447217009053	Zn binding site [ion binding]; other site
447217009054	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217009055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009056	dimer interface [polypeptide binding]; other site
447217009057	phosphorylation site [posttranslational modification]
447217009058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009059	ATP binding site [chemical binding]; other site
447217009060	Mg2+ binding site [ion binding]; other site
447217009061	G-X-G motif; other site
447217009062	Outer membrane efflux protein; Region: OEP; pfam02321
447217009063	Outer membrane efflux protein; Region: OEP; pfam02321
447217009064	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217009065	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217009066	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
447217009067	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217009068	Walker A/P-loop; other site
447217009069	ATP binding site [chemical binding]; other site
447217009070	Q-loop/lid; other site
447217009071	ABC transporter signature motif; other site
447217009072	Walker B; other site
447217009073	D-loop; other site
447217009074	H-loop/switch region; other site
447217009075	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
447217009076	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
447217009077	Walker A/P-loop; other site
447217009078	ATP binding site [chemical binding]; other site
447217009079	Q-loop/lid; other site
447217009080	ABC transporter signature motif; other site
447217009081	Walker B; other site
447217009082	D-loop; other site
447217009083	H-loop/switch region; other site
447217009084	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
447217009085	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
447217009086	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
447217009087	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
447217009088	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
447217009089	Acetokinase family; Region: Acetate_kinase; cl17229
447217009090	propionate/acetate kinase; Provisional; Region: PRK12379
447217009091	putative phosphoketolase; Provisional; Region: PRK05261
447217009092	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
447217009093	TPP-binding site; other site
447217009094	XFP C-terminal domain; Region: XFP_C; pfam09363
447217009095	Thioredoxin; Region: Thioredoxin_4; cl17273
447217009096	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
447217009097	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
447217009098	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
447217009099	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
447217009100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217009101	Walker A/P-loop; other site
447217009102	ATP binding site [chemical binding]; other site
447217009103	Q-loop/lid; other site
447217009104	ABC transporter signature motif; other site
447217009105	Walker B; other site
447217009106	D-loop; other site
447217009107	H-loop/switch region; other site
447217009108	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
447217009109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217009110	dimer interface [polypeptide binding]; other site
447217009111	conserved gate region; other site
447217009112	putative PBP binding loops; other site
447217009113	ABC-ATPase subunit interface; other site
447217009114	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
447217009115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217009116	dimer interface [polypeptide binding]; other site
447217009117	conserved gate region; other site
447217009118	putative PBP binding loops; other site
447217009119	ABC-ATPase subunit interface; other site
447217009120	RNA polymerase factor sigma-70; Validated; Region: PRK08241
447217009121	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217009122	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
447217009123	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
447217009124	DoxX-like family; Region: DoxX_2; pfam13564
447217009125	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
447217009126	Uncharacterized conserved protein [Function unknown]; Region: COG2128
447217009127	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
447217009128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217009129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217009130	DNA binding residues [nucleotide binding]
447217009131	short chain dehydrogenase; Provisional; Region: PRK07041
447217009132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009133	active site
447217009134	GTPase RsgA; Reviewed; Region: PRK01889
447217009135	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
447217009136	GTPase/Zn-binding domain interface [polypeptide binding]; other site
447217009137	GTP/Mg2+ binding site [chemical binding]; other site
447217009138	G4 box; other site
447217009139	G5 box; other site
447217009140	G1 box; other site
447217009141	Switch I region; other site
447217009142	G2 box; other site
447217009143	G3 box; other site
447217009144	Switch II region; other site
447217009145	PilZ domain; Region: PilZ; cl01260
447217009146	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217009147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009148	active site
447217009149	phosphorylation site [posttranslational modification]
447217009150	intermolecular recognition site; other site
447217009151	dimerization interface [polypeptide binding]; other site
447217009152	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
447217009153	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
447217009154	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
447217009155	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
447217009156	active site
447217009157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217009158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217009159	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217009160	classical (c) SDRs; Region: SDR_c; cd05233
447217009161	NAD(P) binding site [chemical binding]; other site
447217009162	active site
447217009163	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
447217009164	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217009165	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217009166	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
447217009167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009168	phosphorylation site [posttranslational modification]
447217009169	dimer interface [polypeptide binding]; other site
447217009170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009171	ATP binding site [chemical binding]; other site
447217009172	Mg2+ binding site [ion binding]; other site
447217009173	G-X-G motif; other site
447217009174	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217009175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009176	active site
447217009177	phosphorylation site [posttranslational modification]
447217009178	intermolecular recognition site; other site
447217009179	dimerization interface [polypeptide binding]; other site
447217009180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009181	Walker A motif; other site
447217009182	ATP binding site [chemical binding]; other site
447217009183	Walker B motif; other site
447217009184	arginine finger; other site
447217009185	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217009186	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
447217009187	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217009188	homodimer interface [polypeptide binding]; other site
447217009189	substrate-cofactor binding pocket; other site
447217009190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009191	catalytic residue [active]
447217009192	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
447217009193	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217009194	Walker A/P-loop; other site
447217009195	ATP binding site [chemical binding]; other site
447217009196	Q-loop/lid; other site
447217009197	ABC transporter signature motif; other site
447217009198	Walker B; other site
447217009199	D-loop; other site
447217009200	H-loop/switch region; other site
447217009201	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217009202	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217009203	FtsX-like permease family; Region: FtsX; pfam02687
447217009204	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217009205	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217009206	active site
447217009207	CHRD domain; Region: CHRD; pfam07452
447217009208	CHRD domain; Region: CHRD; pfam07452
447217009209	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
447217009210	iron-sulfur cluster [ion binding]; other site
447217009211	[2Fe-2S] cluster binding site [ion binding]; other site
447217009212	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217009213	iron-sulfur cluster [ion binding]; other site
447217009214	[2Fe-2S] cluster binding site [ion binding]; other site
447217009215	YceI-like domain; Region: YceI; pfam04264
447217009216	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217009217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
447217009218	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
447217009219	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
447217009220	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
447217009221	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
447217009222	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
447217009223	active site
447217009224	homodimer interface [polypeptide binding]; other site
447217009225	SAM binding site [chemical binding]; other site
447217009226	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
447217009227	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
447217009228	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
447217009229	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
447217009230	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217009231	Soluble P-type ATPase [General function prediction only]; Region: COG4087
447217009232	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217009233	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217009234	ligand binding site [chemical binding]; other site
447217009235	flexible hinge region; other site
447217009236	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217009237	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217009238	metal binding triad; other site
447217009239	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
447217009240	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
447217009241	Uncharacterized conserved protein [Function unknown]; Region: COG1656
447217009242	Protein of unknown function DUF82; Region: DUF82; pfam01927
447217009243	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
447217009244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217009245	dimer interface [polypeptide binding]; other site
447217009246	putative CheW interface [polypeptide binding]; other site
447217009247	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217009248	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217009249	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
447217009250	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217009251	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217009252	putative NAD(P) binding site [chemical binding]; other site
447217009253	putative substrate binding site [chemical binding]; other site
447217009254	catalytic Zn binding site [ion binding]; other site
447217009255	structural Zn binding site [ion binding]; other site
447217009256	dimer interface [polypeptide binding]; other site
447217009257	RibD C-terminal domain; Region: RibD_C; cl17279
447217009258	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
447217009259	ABC-2 type transporter; Region: ABC2_membrane; cl17235
447217009260	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
447217009261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217009262	Walker A/P-loop; other site
447217009263	ATP binding site [chemical binding]; other site
447217009264	Q-loop/lid; other site
447217009265	ABC transporter signature motif; other site
447217009266	Walker B; other site
447217009267	D-loop; other site
447217009268	H-loop/switch region; other site
447217009269	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
447217009270	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217009271	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217009272	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
447217009273	putative effector binding pocket; other site
447217009274	putative dimerization interface [polypeptide binding]; other site
447217009275	UPF0126 domain; Region: UPF0126; pfam03458
447217009276	Predicted membrane protein [Function unknown]; Region: COG2860
447217009277	UPF0126 domain; Region: UPF0126; pfam03458
447217009278	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
447217009279	DNA-binding site [nucleotide binding]; DNA binding site
447217009280	RNA-binding motif; other site
447217009281	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217009282	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
447217009283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217009284	S-adenosylmethionine binding site [chemical binding]; other site
447217009285	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
447217009286	Putative glucoamylase; Region: Glycoamylase; pfam10091
447217009287	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
447217009288	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
447217009289	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
447217009290	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217009291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217009292	Walker A/P-loop; other site
447217009293	ATP binding site [chemical binding]; other site
447217009294	Q-loop/lid; other site
447217009295	ABC transporter signature motif; other site
447217009296	Walker B; other site
447217009297	D-loop; other site
447217009298	H-loop/switch region; other site
447217009299	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
447217009300	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
447217009301	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217009302	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
447217009303	PA/protease or protease-like domain interface [polypeptide binding]; other site
447217009304	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
447217009305	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
447217009306	Uncharacterized conserved protein [Function unknown]; Region: COG2353
447217009307	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
447217009308	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
447217009309	Uncharacterized conserved protein [Function unknown]; Region: COG2461
447217009310	Family of unknown function (DUF438); Region: DUF438; pfam04282
447217009311	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
447217009312	Predicted flavoprotein [General function prediction only]; Region: COG0431
447217009313	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
447217009314	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
447217009315	Prostaglandin dehydrogenases; Region: PGDH; cd05288
447217009316	NAD(P) binding site [chemical binding]; other site
447217009317	substrate binding site [chemical binding]; other site
447217009318	dimer interface [polypeptide binding]; other site
447217009319	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
447217009320	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217009321	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217009322	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217009323	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217009324	active site
447217009325	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
447217009326	FOG: CBS domain [General function prediction only]; Region: COG0517
447217009327	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217009328	FOG: CBS domain [General function prediction only]; Region: COG0517
447217009329	FOG: CBS domain [General function prediction only]; Region: COG0517
447217009330	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217009331	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
447217009332	dimer interface [polypeptide binding]; other site
447217009333	RibD C-terminal domain; Region: RibD_C; cl17279
447217009334	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217009335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009336	NAD(P) binding site [chemical binding]; other site
447217009337	active site
447217009338	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
447217009339	Phosphoesterase family; Region: Phosphoesterase; pfam04185
447217009340	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
447217009341	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
447217009342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217009343	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
447217009344	substrate binding pocket [chemical binding]; other site
447217009345	dimerization interface [polypeptide binding]; other site
447217009346	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
447217009347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217009348	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
447217009349	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217009350	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
447217009351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217009352	AAA domain; Region: AAA_21; pfam13304
447217009353	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
447217009354	active site
447217009355	metal binding site [ion binding]; metal-binding site
447217009356	Family description; Region: UvrD_C_2; pfam13538
447217009357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217009358	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217009359	non-specific DNA binding site [nucleotide binding]; other site
447217009360	salt bridge; other site
447217009361	sequence-specific DNA binding site [nucleotide binding]; other site
447217009362	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
447217009363	Dynamin family; Region: Dynamin_N; pfam00350
447217009364	G1 box; other site
447217009365	GTP/Mg2+ binding site [chemical binding]; other site
447217009366	G2 box; other site
447217009367	Switch I region; other site
447217009368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217009369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217009370	non-specific DNA binding site [nucleotide binding]; other site
447217009371	salt bridge; other site
447217009372	sequence-specific DNA binding site [nucleotide binding]; other site
447217009373	Predicted transcriptional regulator [Transcription]; Region: COG5340
447217009374	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
447217009375	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
447217009376	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217009377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217009378	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
447217009379	putative effector binding pocket; other site
447217009380	putative dimerization interface [polypeptide binding]; other site
447217009381	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217009382	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217009383	putative NAD(P) binding site [chemical binding]; other site
447217009384	putative substrate binding site [chemical binding]; other site
447217009385	catalytic Zn binding site [ion binding]; other site
447217009386	structural Zn binding site [ion binding]; other site
447217009387	dimer interface [polypeptide binding]; other site
447217009388	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
447217009389	Uncharacterized conserved protein [Function unknown]; Region: COG4925
447217009390	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
447217009391	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217009392	catalytic Zn binding site [ion binding]; other site
447217009393	NAD(P) binding site [chemical binding]; other site
447217009394	structural Zn binding site [ion binding]; other site
447217009395	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217009396	active site
447217009397	catalytic tetrad [active]
447217009398	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217009399	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217009400	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
447217009401	putative effector binding pocket; other site
447217009402	putative dimerization interface [polypeptide binding]; other site
447217009403	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217009404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009405	NAD(P) binding site [chemical binding]; other site
447217009406	active site
447217009407	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217009408	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
447217009409	putative NAD(P) binding site [chemical binding]; other site
447217009410	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
447217009411	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217009412	catalytic Zn binding site [ion binding]; other site
447217009413	NAD(P) binding site [chemical binding]; other site
447217009414	structural Zn binding site [ion binding]; other site
447217009415	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217009416	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217009417	dimerization interface [polypeptide binding]; other site
447217009418	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
447217009419	proline aminopeptidase P II; Provisional; Region: PRK10879
447217009420	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
447217009421	active site
447217009422	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
447217009423	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
447217009424	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217009425	Bacterial transcriptional activator domain; Region: BTAD; smart01043
447217009426	AAA ATPase domain; Region: AAA_16; pfam13191
447217009427	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
447217009428	FeoA domain; Region: FeoA; pfam04023
447217009429	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
447217009430	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
447217009431	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
447217009432	G1 box; other site
447217009433	GTP/Mg2+ binding site [chemical binding]; other site
447217009434	Switch I region; other site
447217009435	G2 box; other site
447217009436	G3 box; other site
447217009437	Switch II region; other site
447217009438	G4 box; other site
447217009439	G5 box; other site
447217009440	Nucleoside recognition; Region: Gate; pfam07670
447217009441	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
447217009442	Nucleoside recognition; Region: Gate; pfam07670
447217009443	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
447217009444	NAD(P) binding site [chemical binding]; other site
447217009445	Putative Ig domain; Region: He_PIG; pfam05345
447217009446	Uncharacterized conserved protein [Function unknown]; Region: COG3791
447217009447	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
447217009448	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
447217009449	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
447217009450	Multicopper oxidase; Region: Cu-oxidase; pfam00394
447217009451	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
447217009452	SnoaL-like domain; Region: SnoaL_3; pfam13474
447217009453	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217009454	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217009455	dimer interface [polypeptide binding]; other site
447217009456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009457	catalytic residue [active]
447217009458	FOG: CBS domain [General function prediction only]; Region: COG0517
447217009459	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
447217009460	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
447217009461	Sel1 repeat; Region: Sel1; cl02723
447217009462	Sel1-like repeats; Region: SEL1; smart00671
447217009463	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217009464	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217009465	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217009466	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
447217009467	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
447217009468	Peptidase family M48; Region: Peptidase_M48; cl12018
447217009469	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
447217009470	signal recognition particle protein; Provisional; Region: PRK10867
447217009471	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
447217009472	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
447217009473	P loop; other site
447217009474	GTP binding site [chemical binding]; other site
447217009475	Signal peptide binding domain; Region: SRP_SPB; pfam02978
447217009476	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
447217009477	putative ligand binding pocket/active site [active]
447217009478	putative metal binding site [ion binding]; other site
447217009479	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
447217009480	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
447217009481	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
447217009482	TMP-binding site; other site
447217009483	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
447217009484	putative active site; other site
447217009485	putative metal binding residues [ion binding]; other site
447217009486	signature motif; other site
447217009487	putative triphosphate binding site [ion binding]; other site
447217009488	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217009489	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217009490	active site
447217009491	metal binding site [ion binding]; metal-binding site
447217009492	CotH protein; Region: CotH; pfam08757
447217009493	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217009494	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217009495	phosphopeptide binding site; other site
447217009496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009497	binding surface
447217009498	TPR motif; other site
447217009499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009500	TPR motif; other site
447217009501	binding surface
447217009502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009503	binding surface
447217009504	TPR motif; other site
447217009505	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217009506	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
447217009507	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
447217009508	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217009509	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
447217009510	putative active site [active]
447217009511	putative substrate binding site [chemical binding]; other site
447217009512	ATP binding site [chemical binding]; other site
447217009513	TPR repeat; Region: TPR_11; pfam13414
447217009514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009515	binding surface
447217009516	TPR motif; other site
447217009517	TPR repeat; Region: TPR_11; pfam13414
447217009518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009519	binding surface
447217009520	TPR motif; other site
447217009521	TPR repeat; Region: TPR_11; pfam13414
447217009522	TPR repeat; Region: TPR_11; pfam13414
447217009523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009524	binding surface
447217009525	TPR motif; other site
447217009526	FHA domain; Region: FHA; pfam00498
447217009527	phosphopeptide binding site; other site
447217009528	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217009529	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217009530	phosphopeptide binding site; other site
447217009531	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217009532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009533	Walker A motif; other site
447217009534	ATP binding site [chemical binding]; other site
447217009535	Walker B motif; other site
447217009536	arginine finger; other site
447217009537	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217009538	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217009539	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217009540	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
447217009541	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217009542	ligand binding site [chemical binding]; other site
447217009543	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217009544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009545	active site
447217009546	phosphorylation site [posttranslational modification]
447217009547	intermolecular recognition site; other site
447217009548	dimerization interface [polypeptide binding]; other site
447217009549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009550	Walker A motif; other site
447217009551	ATP binding site [chemical binding]; other site
447217009552	Walker B motif; other site
447217009553	arginine finger; other site
447217009554	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217009555	Transglycosylase; Region: Transgly; pfam00912
447217009556	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
447217009557	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
447217009558	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
447217009559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009560	dimer interface [polypeptide binding]; other site
447217009561	phosphorylation site [posttranslational modification]
447217009562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009563	ATP binding site [chemical binding]; other site
447217009564	Mg2+ binding site [ion binding]; other site
447217009565	G-X-G motif; other site
447217009566	Peptidase S46; Region: Peptidase_S46; pfam10459
447217009567	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
447217009568	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
447217009569	quinolinate synthetase; Provisional; Region: PRK09375
447217009570	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217009571	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217009572	active site
447217009573	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
447217009574	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217009575	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217009576	Mediator complex protein; Region: Med11; pfam10280
447217009577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009578	Walker A motif; other site
447217009579	ATP binding site [chemical binding]; other site
447217009580	Walker B motif; other site
447217009581	arginine finger; other site
447217009582	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
447217009583	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217009584	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217009585	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217009586	catalytic residue [active]
447217009587	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217009588	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
447217009589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009590	Walker A motif; other site
447217009591	ATP binding site [chemical binding]; other site
447217009592	Walker B motif; other site
447217009593	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
447217009594	Clp protease; Region: CLP_protease; pfam00574
447217009595	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
447217009596	oligomer interface [polypeptide binding]; other site
447217009597	active site residues [active]
447217009598	trigger factor; Region: tig; TIGR00115
447217009599	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
447217009600	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
447217009601	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
447217009602	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
447217009603	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578
447217009604	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
447217009605	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
447217009606	Ligand binding site; other site
447217009607	Putative Catalytic site; other site
447217009608	DXD motif; other site
447217009609	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
447217009610	active site
447217009611	dimerization interface [polypeptide binding]; other site
447217009612	ribonuclease PH; Reviewed; Region: rph; PRK00173
447217009613	Ribonuclease PH; Region: RNase_PH_bact; cd11362
447217009614	hexamer interface [polypeptide binding]; other site
447217009615	active site
447217009616	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
447217009617	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
447217009618	active site
447217009619	metal binding site [ion binding]; metal-binding site
447217009620	selenium donor protein; Region: selD; TIGR00476
447217009621	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
447217009622	dimerization interface [polypeptide binding]; other site
447217009623	putative ATP binding site [chemical binding]; other site
447217009624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009625	binding surface
447217009626	TPR motif; other site
447217009627	TPR repeat; Region: TPR_11; pfam13414
447217009628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217009629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009630	binding surface
447217009631	TPR motif; other site
447217009632	Outer membrane lipoprotein; Region: YfiO; pfam13525
447217009633	RecX family; Region: RecX; cl00936
447217009634	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
447217009635	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217009636	ATP binding site [chemical binding]; other site
447217009637	Walker B motif; other site
447217009638	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217009639	PLD-like domain; Region: PLDc_2; pfam13091
447217009640	putative active site [active]
447217009641	catalytic site [active]
447217009642	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
447217009643	PLD-like domain; Region: PLDc_2; pfam13091
447217009644	putative active site [active]
447217009645	catalytic site [active]
447217009646	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
447217009647	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
447217009648	23S rRNA interface [nucleotide binding]; other site
447217009649	L3 interface [polypeptide binding]; other site
447217009650	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
447217009651	Part of AAA domain; Region: AAA_19; pfam13245
447217009652	Family description; Region: UvrD_C_2; pfam13538
447217009653	DoxX; Region: DoxX; pfam07681
447217009654	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
447217009655	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
447217009656	CGNR zinc finger; Region: zf-CGNR; pfam11706
447217009657	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
447217009658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217009659	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217009660	putative substrate translocation pore; other site
447217009661	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217009662	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217009663	active site
447217009664	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
447217009665	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
447217009666	putative C-terminal domain interface [polypeptide binding]; other site
447217009667	putative GSH binding site (G-site) [chemical binding]; other site
447217009668	putative dimer interface [polypeptide binding]; other site
447217009669	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
447217009670	N-terminal domain interface [polypeptide binding]; other site
447217009671	dimer interface [polypeptide binding]; other site
447217009672	substrate binding pocket (H-site) [chemical binding]; other site
447217009673	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217009674	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217009675	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217009676	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217009677	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217009678	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217009679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217009680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217009681	dimerization interface [polypeptide binding]; other site
447217009682	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009683	dimer interface [polypeptide binding]; other site
447217009684	phosphorylation site [posttranslational modification]
447217009685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009686	ATP binding site [chemical binding]; other site
447217009687	Mg2+ binding site [ion binding]; other site
447217009688	G-X-G motif; other site
447217009689	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217009690	Walker A/P-loop; other site
447217009691	ATP binding site [chemical binding]; other site
447217009692	Q-loop/lid; other site
447217009693	ABC transporter signature motif; other site
447217009694	Walker B; other site
447217009695	D-loop; other site
447217009696	H-loop/switch region; other site
447217009697	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
447217009698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217009699	Walker A/P-loop; other site
447217009700	ATP binding site [chemical binding]; other site
447217009701	Q-loop/lid; other site
447217009702	ABC transporter signature motif; other site
447217009703	Walker B; other site
447217009704	D-loop; other site
447217009705	H-loop/switch region; other site
447217009706	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217009707	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217009708	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
447217009709	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
447217009710	active site
447217009711	dimerization interface [polypeptide binding]; other site
447217009712	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
447217009713	putative active site [active]
447217009714	Zn binding site [ion binding]; other site
447217009715	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217009716	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217009717	catalytic residues [active]
447217009718	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
447217009719	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
447217009720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217009721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217009722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217009723	Beta-lactamase; Region: Beta-lactamase; pfam00144
447217009724	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
447217009725	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
447217009726	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
447217009727	dimer interface [polypeptide binding]; other site
447217009728	catalytic triad [active]
447217009729	acetyl-CoA synthetase; Provisional; Region: PRK00174
447217009730	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
447217009731	active site
447217009732	CoA binding site [chemical binding]; other site
447217009733	acyl-activating enzyme (AAE) consensus motif; other site
447217009734	AMP binding site [chemical binding]; other site
447217009735	acetate binding site [chemical binding]; other site
447217009736	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
447217009737	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
447217009738	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
447217009739	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
447217009740	glutathione S-transferase; Provisional; Region: PRK15113
447217009741	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
447217009742	C-terminal domain interface [polypeptide binding]; other site
447217009743	GSH binding site (G-site) [chemical binding]; other site
447217009744	dimer interface [polypeptide binding]; other site
447217009745	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
447217009746	N-terminal domain interface [polypeptide binding]; other site
447217009747	putative dimer interface [polypeptide binding]; other site
447217009748	putative substrate binding pocket (H-site) [chemical binding]; other site
447217009749	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
447217009750	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217009751	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217009752	dimer interface [polypeptide binding]; other site
447217009753	putative CheW interface [polypeptide binding]; other site
447217009754	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
447217009755	Protein of unknown function, DUF481; Region: DUF481; pfam04338
447217009756	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217009757	ATP binding site [chemical binding]; other site
447217009758	putative Mg++ binding site [ion binding]; other site
447217009759	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217009760	nucleotide binding region [chemical binding]; other site
447217009761	ATP-binding site [chemical binding]; other site
447217009762	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
447217009763	Uncharacterized conserved protein [Function unknown]; Region: COG4095
447217009764	Protein of unknown function, DUF488; Region: DUF488; pfam04343
447217009765	RF-1 domain; Region: RF-1; pfam00472
447217009766	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
447217009767	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
447217009768	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
447217009769	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
447217009770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009771	TPR motif; other site
447217009772	binding surface
447217009773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009774	binding surface
447217009775	TPR motif; other site
447217009776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009777	binding surface
447217009778	TPR motif; other site
447217009779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
447217009780	Protein of unknown function, DUF482; Region: DUF482; pfam04339
447217009781	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
447217009782	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
447217009783	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
447217009784	maleylacetoacetate isomerase; Region: maiA; TIGR01262
447217009785	C-terminal domain interface [polypeptide binding]; other site
447217009786	GSH binding site (G-site) [chemical binding]; other site
447217009787	putative dimer interface [polypeptide binding]; other site
447217009788	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
447217009789	dimer interface [polypeptide binding]; other site
447217009790	N-terminal domain interface [polypeptide binding]; other site
447217009791	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
447217009792	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
447217009793	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
447217009794	dimer interface [polypeptide binding]; other site
447217009795	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
447217009796	active site
447217009797	Fe binding site [ion binding]; other site
447217009798	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
447217009799	alanine racemase; Reviewed; Region: alr; PRK00053
447217009800	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
447217009801	active site
447217009802	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217009803	dimer interface [polypeptide binding]; other site
447217009804	substrate binding site [chemical binding]; other site
447217009805	catalytic residues [active]
447217009806	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
447217009807	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
447217009808	homodimer interface [polypeptide binding]; other site
447217009809	substrate-cofactor binding pocket; other site
447217009810	catalytic residue [active]
447217009811	MarR family; Region: MarR_2; pfam12802
447217009812	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
447217009813	active site 2 [active]
447217009814	active site 1 [active]
447217009815	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217009816	motif 1; other site
447217009817	dimer interface [polypeptide binding]; other site
447217009818	active site
447217009819	motif 2; other site
447217009820	motif 3; other site
447217009821	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217009822	Amidase; Region: Amidase; cl11426
447217009823	Amidase; Region: Amidase; cl11426
447217009824	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
447217009825	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
447217009826	TrkA-C domain; Region: TrkA_C; pfam02080
447217009827	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
447217009828	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
447217009829	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
447217009830	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
447217009831	active site
447217009832	Zn binding site [ion binding]; other site
447217009833	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
447217009834	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
447217009835	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
447217009836	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
447217009837	active site
447217009838	PHP Thumb interface [polypeptide binding]; other site
447217009839	metal binding site [ion binding]; metal-binding site
447217009840	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
447217009841	generic binding surface II; other site
447217009842	generic binding surface I; other site
447217009843	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
447217009844	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217009845	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217009846	DNA binding residues [nucleotide binding]
447217009847	dimerization interface [polypeptide binding]; other site
447217009848	threonine dehydratase; Provisional; Region: PRK08198
447217009849	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
447217009850	tetramer interface [polypeptide binding]; other site
447217009851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009852	catalytic residue [active]
447217009853	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
447217009854	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217009855	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217009856	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217009857	active site
447217009858	ATP binding site [chemical binding]; other site
447217009859	substrate binding site [chemical binding]; other site
447217009860	activation loop (A-loop); other site
447217009861	Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647
447217009862	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
447217009863	structural tetrad; other site
447217009864	PQQ-like domain; Region: PQQ_2; pfam13360
447217009865	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
447217009866	structural tetrad; other site
447217009867	FOG: WD40 repeat [General function prediction only]; Region: COG2319
447217009868	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
447217009869	structural tetrad; other site
447217009870	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
447217009871	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
447217009872	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217009873	catalytic residue [active]
447217009874	biotin synthase; Region: bioB; TIGR00433
447217009875	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217009876	FeS/SAM binding site; other site
447217009877	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
447217009878	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
447217009879	DNA repair protein RadA; Provisional; Region: PRK11823
447217009880	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217009881	Walker A motif; other site
447217009882	ATP binding site [chemical binding]; other site
447217009883	Walker B motif; other site
447217009884	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
447217009885	glycerol kinase; Provisional; Region: glpK; PRK00047
447217009886	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
447217009887	N- and C-terminal domain interface [polypeptide binding]; other site
447217009888	active site
447217009889	MgATP binding site [chemical binding]; other site
447217009890	catalytic site [active]
447217009891	metal binding site [ion binding]; metal-binding site
447217009892	glycerol binding site [chemical binding]; other site
447217009893	homotetramer interface [polypeptide binding]; other site
447217009894	homodimer interface [polypeptide binding]; other site
447217009895	FBP binding site [chemical binding]; other site
447217009896	protein IIAGlc interface [polypeptide binding]; other site
447217009897	Esterase/lipase [General function prediction only]; Region: COG1647
447217009898	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
447217009899	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
447217009900	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
447217009901	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
447217009902	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
447217009903	Uncharacterized conserved protein [Function unknown]; Region: COG3391
447217009904	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
447217009905	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217009906	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217009907	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
447217009908	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
447217009909	dimer interface [polypeptide binding]; other site
447217009910	putative PBP binding regions; other site
447217009911	ABC-ATPase subunit  interface; other site
447217009912	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
447217009913	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
447217009914	Walker A/P-loop; other site
447217009915	ATP binding site [chemical binding]; other site
447217009916	Q-loop/lid; other site
447217009917	ABC transporter signature motif; other site
447217009918	Walker B; other site
447217009919	D-loop; other site
447217009920	H-loop/switch region; other site
447217009921	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217009922	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217009923	active site
447217009924	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
447217009925	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
447217009926	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
447217009927	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
447217009928	active site
447217009929	tetramer interface; other site
447217009930	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217009931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009932	active site
447217009933	phosphorylation site [posttranslational modification]
447217009934	intermolecular recognition site; other site
447217009935	dimerization interface [polypeptide binding]; other site
447217009936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009937	Walker A motif; other site
447217009938	ATP binding site [chemical binding]; other site
447217009939	Walker B motif; other site
447217009940	arginine finger; other site
447217009941	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217009942	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009944	active site
447217009945	phosphorylation site [posttranslational modification]
447217009946	intermolecular recognition site; other site
447217009947	dimerization interface [polypeptide binding]; other site
447217009948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009949	dimer interface [polypeptide binding]; other site
447217009950	phosphorylation site [posttranslational modification]
447217009951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009952	ATP binding site [chemical binding]; other site
447217009953	G-X-G motif; other site
447217009954	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009956	active site
447217009957	phosphorylation site [posttranslational modification]
447217009958	intermolecular recognition site; other site
447217009959	dimerization interface [polypeptide binding]; other site
447217009960	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217009961	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217009962	metal binding site [ion binding]; metal-binding site
447217009963	active site
447217009964	I-site; other site
447217009965	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
447217009966	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
447217009967	pteridine reductase; Provisional; Region: PRK09135
447217009968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009969	NAD(P) binding site [chemical binding]; other site
447217009970	active site
447217009971	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
447217009972	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
447217009973	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
447217009974	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
447217009975	NAD binding site [chemical binding]; other site
447217009976	homotetramer interface [polypeptide binding]; other site
447217009977	homodimer interface [polypeptide binding]; other site
447217009978	substrate binding site [chemical binding]; other site
447217009979	active site
447217009980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009981	TPR motif; other site
447217009982	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217009983	binding surface
447217009984	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
447217009985	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
447217009986	GTP binding site; other site
447217009987	camphor resistance protein CrcB; Provisional; Region: PRK14208
447217009988	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
447217009989	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217009990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217009991	S-adenosylmethionine binding site [chemical binding]; other site
447217009992	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217009993	Pirin-related protein [General function prediction only]; Region: COG1741
447217009994	Pirin; Region: Pirin; pfam02678
447217009995	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
447217009996	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009997	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009998	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009999	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
447217010000	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
447217010001	MPN+ (JAMM) motif; other site
447217010002	Zinc-binding site [ion binding]; other site
447217010003	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
447217010004	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
447217010005	ATP binding site [chemical binding]; other site
447217010006	substrate interface [chemical binding]; other site
447217010007	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217010008	active site residue [active]
447217010009	Ubiquitin-like proteins; Region: UBQ; cl00155
447217010010	charged pocket; other site
447217010011	hydrophobic patch; other site
447217010012	threonine synthase; Validated; Region: PRK07591
447217010013	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
447217010014	homodimer interface [polypeptide binding]; other site
447217010015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010016	catalytic residue [active]
447217010017	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
447217010018	putative homodimer interface [polypeptide binding]; other site
447217010019	putative homotetramer interface [polypeptide binding]; other site
447217010020	putative allosteric switch controlling residues; other site
447217010021	putative metal binding site [ion binding]; other site
447217010022	putative homodimer-homodimer interface [polypeptide binding]; other site
447217010023	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
447217010024	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
447217010025	metal-binding site [ion binding]
447217010026	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217010027	Soluble P-type ATPase [General function prediction only]; Region: COG4087
447217010028	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
447217010029	SnoaL-like domain; Region: SnoaL_3; pfam13474
447217010030	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
447217010031	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010032	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
447217010033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
447217010034	Phosphoesterase family; Region: Phosphoesterase; pfam04185
447217010035	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217010036	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217010037	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
447217010038	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217010039	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217010040	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217010041	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217010042	active site
447217010043	catalytic tetrad [active]
447217010044	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217010045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
447217010046	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217010047	dimerization interface [polypeptide binding]; other site
447217010048	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217010049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217010050	catalytic residues [active]
447217010051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
447217010052	putative lipid kinase; Reviewed; Region: PRK13057
447217010053	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
447217010054	Hemerythrin-like domain; Region: Hr-like; cd12108
447217010055	HAMP domain; Region: HAMP; pfam00672
447217010056	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217010057	dimer interface [polypeptide binding]; other site
447217010058	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
447217010059	putative CheW interface [polypeptide binding]; other site
447217010060	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
447217010061	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217010062	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217010063	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
447217010064	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217010065	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217010066	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
447217010067	IMP binding site; other site
447217010068	dimer interface [polypeptide binding]; other site
447217010069	Outer membrane efflux protein; Region: OEP; pfam02321
447217010070	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
447217010071	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217010072	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217010073	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217010074	Walker A/P-loop; other site
447217010075	ATP binding site [chemical binding]; other site
447217010076	Q-loop/lid; other site
447217010077	ABC transporter signature motif; other site
447217010078	Walker B; other site
447217010079	D-loop; other site
447217010080	H-loop/switch region; other site
447217010081	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217010082	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217010083	FtsX-like permease family; Region: FtsX; pfam02687
447217010084	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
447217010085	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
447217010086	active site residue [active]
447217010087	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
447217010088	active site residue [active]
447217010089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010090	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010091	active site
447217010092	phosphorylation site [posttranslational modification]
447217010093	intermolecular recognition site; other site
447217010094	dimerization interface [polypeptide binding]; other site
447217010095	HEAT repeats; Region: HEAT_2; pfam13646
447217010096	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
447217010097	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
447217010098	DXD motif; other site
447217010099	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
447217010100	HflK protein; Region: hflK; TIGR01933
447217010101	HflC protein; Region: hflC; TIGR01932
447217010102	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
447217010103	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
447217010104	Predicted oxidoreductase [General function prediction only]; Region: COG3573
447217010105	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
447217010106	catalytic triad [active]
447217010107	GAF domain; Region: GAF; cl17456
447217010108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010109	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217010110	dimer interface [polypeptide binding]; other site
447217010111	phosphorylation site [posttranslational modification]
447217010112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010113	ATP binding site [chemical binding]; other site
447217010114	Mg2+ binding site [ion binding]; other site
447217010115	G-X-G motif; other site
447217010116	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
447217010117	Peptidase family M48; Region: Peptidase_M48; cl12018
447217010118	RibD C-terminal domain; Region: RibD_C; cl17279
447217010119	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
447217010120	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217010121	non-specific DNA binding site [nucleotide binding]; other site
447217010122	salt bridge; other site
447217010123	sequence-specific DNA binding site [nucleotide binding]; other site
447217010124	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
447217010125	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
447217010126	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
447217010127	putative active site [active]
447217010128	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217010129	TPR repeat; Region: TPR_11; pfam13414
447217010130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217010131	TPR motif; other site
447217010132	binding surface
447217010133	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217010134	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
447217010135	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
447217010136	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
447217010137	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217010138	catalytic residue [active]
447217010139	L-aspartate oxidase; Provisional; Region: PRK06175
447217010140	L-aspartate oxidase; Provisional; Region: PRK09077
447217010141	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217010142	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217010143	active site
447217010144	ParB-like nuclease domain; Region: ParBc; cl02129
447217010145	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217010146	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217010147	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
447217010148	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217010149	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
447217010150	DNA binding residues [nucleotide binding]
447217010151	nitrilase; Region: PLN02798
447217010152	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
447217010153	putative active site [active]
447217010154	catalytic triad [active]
447217010155	dimer interface [polypeptide binding]; other site
447217010156	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217010157	Interdomain contacts; other site
447217010158	Cytokine receptor motif; other site
447217010159	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
447217010160	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
447217010161	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010162	TIGR01777 family protein; Region: yfcH
447217010163	NAD(P) binding site [chemical binding]; other site
447217010164	active site
447217010165	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
447217010166	Peptidase family M50; Region: Peptidase_M50; pfam02163
447217010167	active site
447217010168	putative substrate binding region [chemical binding]; other site
447217010169	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
447217010170	Glycoprotease family; Region: Peptidase_M22; pfam00814
447217010171	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217010172	active site
447217010173	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217010174	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217010175	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
447217010176	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217010177	putative substrate binding region [chemical binding]; other site
447217010178	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
447217010179	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
447217010180	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
447217010181	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
447217010182	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
447217010183	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
447217010184	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
447217010185	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
447217010186	catalytic residue [active]
447217010187	putative FPP diphosphate  binding site; other site
447217010188	putative FPP binding hydrophobic cleft; other site
447217010189	dimer interface [polypeptide binding]; other site
447217010190	putative IPP diphosphate binding site; other site
447217010191	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010192	active site
447217010193	ATP binding site [chemical binding]; other site
447217010194	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010195	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217010196	substrate binding site [chemical binding]; other site
447217010197	activation loop (A-loop); other site
447217010198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010199	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217010200	Walker A motif; other site
447217010201	ATP binding site [chemical binding]; other site
447217010202	Walker B motif; other site
447217010203	aspartate kinase; Reviewed; Region: PRK06635
447217010204	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
447217010205	putative nucleotide binding site [chemical binding]; other site
447217010206	putative catalytic residues [active]
447217010207	putative Mg ion binding site [ion binding]; other site
447217010208	putative aspartate binding site [chemical binding]; other site
447217010209	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217010210	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
447217010211	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
447217010212	oligomerisation interface [polypeptide binding]; other site
447217010213	mobile loop; other site
447217010214	roof hairpin; other site
447217010215	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
447217010216	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
447217010217	ring oligomerisation interface [polypeptide binding]; other site
447217010218	ATP/Mg binding site [chemical binding]; other site
447217010219	stacking interactions; other site
447217010220	hinge regions; other site
447217010221	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217010222	Zn binding site [ion binding]; other site
447217010223	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217010224	binding surface
447217010225	TPR motif; other site
447217010226	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217010227	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
447217010228	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
447217010229	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
447217010230	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
447217010231	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
447217010232	Spore Coat Protein U domain; Region: SCPU; pfam05229
447217010233	Spore Coat Protein U domain; Region: SCPU; pfam05229
447217010234	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217010235	active site
447217010236	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
447217010237	amphipathic channel; other site
447217010238	Asn-Pro-Ala signature motifs; other site
447217010239	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
447217010240	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
447217010241	RDD family; Region: RDD; pfam06271
447217010242	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
447217010243	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
447217010244	active site
447217010245	catalytic residues [active]
447217010246	DNA binding site [nucleotide binding]
447217010247	Int/Topo IB signature motif; other site
447217010248	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
447217010249	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217010250	minor groove reading motif; other site
447217010251	helix-hairpin-helix signature motif; other site
447217010252	substrate binding pocket [chemical binding]; other site
447217010253	active site
447217010254	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
447217010255	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
447217010256	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
447217010257	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
447217010258	tetramer interfaces [polypeptide binding]; other site
447217010259	binuclear metal-binding site [ion binding]; other site
447217010260	competence damage-inducible protein A; Provisional; Region: PRK00549
447217010261	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
447217010262	putative MPT binding site; other site
447217010263	Competence-damaged protein; Region: CinA; pfam02464
447217010264	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
447217010265	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217010266	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217010267	Surface antigen; Region: Bac_surface_Ag; pfam01103
447217010268	recombinase A; Provisional; Region: recA; PRK09354
447217010269	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
447217010270	hexamer interface [polypeptide binding]; other site
447217010271	Walker A motif; other site
447217010272	ATP binding site [chemical binding]; other site
447217010273	Walker B motif; other site
447217010274	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
447217010275	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
447217010276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010277	Walker A motif; other site
447217010278	ATP binding site [chemical binding]; other site
447217010279	Walker B motif; other site
447217010280	arginine finger; other site
447217010281	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
447217010282	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
447217010283	Fe-S cluster binding site [ion binding]; other site
447217010284	DNA binding site [nucleotide binding]
447217010285	active site
447217010286	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
447217010287	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217010288	G1 box; other site
447217010289	GTP/Mg2+ binding site [chemical binding]; other site
447217010290	G2 box; other site
447217010291	Switch I region; other site
447217010292	G3 box; other site
447217010293	Switch II region; other site
447217010294	G4 box; other site
447217010295	G5 box; other site
447217010296	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
447217010297	recombination protein RecR; Reviewed; Region: recR; PRK00076
447217010298	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
447217010299	RecR protein; Region: RecR; pfam02132
447217010300	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
447217010301	putative active site [active]
447217010302	putative metal-binding site [ion binding]; other site
447217010303	tetramer interface [polypeptide binding]; other site
447217010304	hypothetical protein; Provisional; Region: PRK14622
447217010305	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
447217010306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010307	Walker A motif; other site
447217010308	ATP binding site [chemical binding]; other site
447217010309	Walker B motif; other site
447217010310	arginine finger; other site
447217010311	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
447217010312	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
447217010313	nucleoside/Zn binding site; other site
447217010314	dimer interface [polypeptide binding]; other site
447217010315	catalytic motif [active]
447217010316	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
447217010317	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217010318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217010319	FeS/SAM binding site; other site
447217010320	Thioredoxin; Region: Thioredoxin_4; pfam13462
447217010321	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217010322	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217010323	GAF domain; Region: GAF; cl17456
447217010324	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
447217010325	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217010326	ligand binding site [chemical binding]; other site
447217010327	Predicted membrane protein [Function unknown]; Region: COG2261
447217010328	TPR repeat; Region: TPR_11; pfam13414
447217010329	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217010330	binding surface
447217010331	TPR motif; other site
447217010332	PEGA domain; Region: PEGA; pfam08308
447217010333	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010334	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010335	active site
447217010336	ATP binding site [chemical binding]; other site
447217010337	substrate binding site [chemical binding]; other site
447217010338	activation loop (A-loop); other site
447217010339	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217010340	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217010341	phosphopeptide binding site; other site
447217010342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010343	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217010344	Walker A motif; other site
447217010345	ATP binding site [chemical binding]; other site
447217010346	Walker B motif; other site
447217010347	arginine finger; other site
447217010348	Helix-turn-helix domain; Region: HTH_17; pfam12728
447217010349	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
447217010350	active site
447217010351	phosphorylation site [posttranslational modification]
447217010352	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217010353	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217010354	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
447217010355	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
447217010356	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
447217010357	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
447217010358	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
447217010359	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
447217010360	4Fe-4S binding domain; Region: Fer4; pfam00037
447217010361	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
447217010362	PspC domain; Region: PspC; pfam04024
447217010363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217010364	S-adenosylmethionine binding site [chemical binding]; other site
447217010365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
447217010366	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
447217010367	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
447217010368	active site
447217010369	aconitate hydratase; Validated; Region: PRK09277
447217010370	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
447217010371	substrate binding site [chemical binding]; other site
447217010372	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
447217010373	ligand binding site [chemical binding]; other site
447217010374	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
447217010375	substrate binding site [chemical binding]; other site
447217010376	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
447217010377	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
447217010378	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
447217010379	type I citrate synthase; Reviewed; Region: PRK09569
447217010380	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
447217010381	oxalacetate binding site [chemical binding]; other site
447217010382	citrylCoA binding site [chemical binding]; other site
447217010383	coenzyme A binding site [chemical binding]; other site
447217010384	catalytic triad [active]
447217010385	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
447217010386	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217010387	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
447217010388	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217010389	RNA binding site [nucleotide binding]; other site
447217010390	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
447217010391	RNA binding site [nucleotide binding]; other site
447217010392	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
447217010393	RNA binding site [nucleotide binding]; other site
447217010394	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
447217010395	RNA binding site [nucleotide binding]; other site
447217010396	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
447217010397	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
447217010398	catalytic site [active]
447217010399	active site
447217010400	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
447217010401	active site
447217010402	substrate-binding site [chemical binding]; other site
447217010403	metal-binding site [ion binding]
447217010404	GTP binding site [chemical binding]; other site
447217010405	NRDE protein; Region: NRDE; cl01315
447217010406	Protein of unknown function (DUF971); Region: DUF971; pfam06155
447217010407	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
447217010408	SmpB-tmRNA interface; other site
447217010409	Pantoate-beta-alanine ligase; Region: PanC; cd00560
447217010410	pantoate--beta-alanine ligase; Region: panC; TIGR00018
447217010411	active site
447217010412	ATP-binding site [chemical binding]; other site
447217010413	pantoate-binding site; other site
447217010414	HXXH motif; other site
447217010415	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
447217010416	oligomerization interface [polypeptide binding]; other site
447217010417	active site
447217010418	metal binding site [ion binding]; metal-binding site
447217010419	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
447217010420	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
447217010421	Substrate-binding site [chemical binding]; other site
447217010422	Substrate specificity [chemical binding]; other site
447217010423	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
447217010424	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
447217010425	UGMP family protein; Validated; Region: PRK09604
447217010426	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
447217010427	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010429	active site
447217010430	phosphorylation site [posttranslational modification]
447217010431	intermolecular recognition site; other site
447217010432	dimerization interface [polypeptide binding]; other site
447217010433	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217010434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217010435	TPR repeat; Region: TPR_11; pfam13414
447217010436	TPR motif; other site
447217010437	binding surface
447217010438	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217010439	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217010440	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217010441	HSP70 interaction site [polypeptide binding]; other site
447217010442	Protein phosphatase 2C; Region: PP2C; pfam00481
447217010443	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
447217010444	active site
447217010445	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
447217010446	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217010447	active site
447217010448	MFS_1 like family; Region: MFS_1_like; pfam12832
447217010449	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
447217010450	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
447217010451	active site
447217010452	catalytic site [active]
447217010453	substrate binding site [chemical binding]; other site
447217010454	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217010455	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217010456	ligand binding site [chemical binding]; other site
447217010457	flexible hinge region; other site
447217010458	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217010459	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217010460	metal binding triad; other site
447217010461	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217010462	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
447217010463	Na binding site [ion binding]; other site
447217010464	putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647
447217010465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010466	putative substrate translocation pore; other site
447217010467	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010468	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010469	active site
447217010470	ATP binding site [chemical binding]; other site
447217010471	substrate binding site [chemical binding]; other site
447217010472	activation loop (A-loop); other site
447217010473	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217010474	Ligand Binding Site [chemical binding]; other site
447217010475	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
447217010476	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217010477	active site
447217010478	metal binding site [ion binding]; metal-binding site
447217010479	Protein of unknown function, DUF485; Region: DUF485; pfam04341
447217010480	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217010481	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
447217010482	Na binding site [ion binding]; other site
447217010483	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217010484	HAMP domain; Region: HAMP; pfam00672
447217010485	dimerization interface [polypeptide binding]; other site
447217010486	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217010487	dimer interface [polypeptide binding]; other site
447217010488	putative CheW interface [polypeptide binding]; other site
447217010489	Phosphotransferase enzyme family; Region: APH; pfam01636
447217010490	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
447217010491	active site
447217010492	ATP binding site [chemical binding]; other site
447217010493	substrate binding site [chemical binding]; other site
447217010494	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
447217010495	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217010496	dimer interface [polypeptide binding]; other site
447217010497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010498	catalytic residue [active]
447217010499	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
447217010500	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
447217010501	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217010502	homodimer interface [polypeptide binding]; other site
447217010503	substrate-cofactor binding pocket; other site
447217010504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010505	catalytic residue [active]
447217010506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010507	putative substrate translocation pore; other site
447217010508	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
447217010509	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
447217010510	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
447217010511	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
447217010512	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
447217010513	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
447217010514	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
447217010515	catalytic site [active]
447217010516	active site
447217010517	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
447217010518	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
447217010519	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217010520	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217010521	dimer interface [polypeptide binding]; other site
447217010522	putative CheW interface [polypeptide binding]; other site
447217010523	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
447217010524	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
447217010525	active site
447217010526	FMN binding site [chemical binding]; other site
447217010527	substrate binding site [chemical binding]; other site
447217010528	homotetramer interface [polypeptide binding]; other site
447217010529	catalytic residue [active]
447217010530	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217010531	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
447217010532	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
447217010533	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
447217010534	putative RNA binding site [nucleotide binding]; other site
447217010535	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217010536	S-adenosylmethionine binding site [chemical binding]; other site
447217010537	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217010538	ligand binding site [chemical binding]; other site
447217010539	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
447217010540	active site
447217010541	PAS domain; Region: PAS_9; pfam13426
447217010542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010543	putative active site [active]
447217010544	heme pocket [chemical binding]; other site
447217010545	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217010546	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
447217010547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217010548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010549	ATP binding site [chemical binding]; other site
447217010550	Mg2+ binding site [ion binding]; other site
447217010551	G-X-G motif; other site
447217010552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217010553	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
447217010554	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217010555	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
447217010556	motif 1; other site
447217010557	dimer interface [polypeptide binding]; other site
447217010558	active site
447217010559	motif 2; other site
447217010560	motif 3; other site
447217010561	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217010562	Zn binding site [ion binding]; other site
447217010563	PAS domain; Region: PAS_9; pfam13426
447217010564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010565	putative active site [active]
447217010566	heme pocket [chemical binding]; other site
447217010567	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010568	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217010569	putative active site [active]
447217010570	heme pocket [chemical binding]; other site
447217010571	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010572	dimer interface [polypeptide binding]; other site
447217010573	phosphorylation site [posttranslational modification]
447217010574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010575	ATP binding site [chemical binding]; other site
447217010576	Mg2+ binding site [ion binding]; other site
447217010577	G-X-G motif; other site
447217010578	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217010579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010580	active site
447217010581	phosphorylation site [posttranslational modification]
447217010582	intermolecular recognition site; other site
447217010583	dimerization interface [polypeptide binding]; other site
447217010584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010585	Walker A motif; other site
447217010586	ATP binding site [chemical binding]; other site
447217010587	Walker B motif; other site
447217010588	arginine finger; other site
447217010589	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217010590	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
447217010591	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
447217010592	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217010593	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217010594	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
447217010595	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
447217010596	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217010597	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
447217010598	Methyltransferase domain; Region: Methyltransf_11; pfam08241
447217010599	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217010600	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010601	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217010602	DNA binding residues [nucleotide binding]
447217010603	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
447217010604	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
447217010605	glycogen binding site [chemical binding]; other site
447217010606	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010607	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010608	active site
447217010609	ATP binding site [chemical binding]; other site
447217010610	substrate binding site [chemical binding]; other site
447217010611	activation loop (A-loop); other site
447217010612	PEGA domain; Region: PEGA; pfam08308
447217010613	PEGA domain; Region: PEGA; pfam08308
447217010614	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217010615	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
447217010616	phosphopeptide binding site; other site
447217010617	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
447217010618	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217010619	substrate binding site [chemical binding]; other site
447217010620	oxyanion hole (OAH) forming residues; other site
447217010621	trimer interface [polypeptide binding]; other site
447217010622	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217010623	carboxyltransferase (CT) interaction site; other site
447217010624	biotinylation site [posttranslational modification]; other site
447217010625	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
447217010626	CoenzymeA binding site [chemical binding]; other site
447217010627	subunit interaction site [polypeptide binding]; other site
447217010628	PHB binding site; other site
447217010629	PilZ domain; Region: PilZ; cl01260
447217010630	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217010631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010632	active site
447217010633	phosphorylation site [posttranslational modification]
447217010634	intermolecular recognition site; other site
447217010635	dimerization interface [polypeptide binding]; other site
447217010636	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
447217010637	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010638	NAD(P) binding site [chemical binding]; other site
447217010639	active site
447217010640	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
447217010641	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
447217010642	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217010643	ligand binding site [chemical binding]; other site
447217010644	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
447217010645	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
447217010646	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010647	catalytic residue [active]
447217010648	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
447217010649	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
447217010650	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
447217010651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217010652	putative PBP binding loops; other site
447217010653	dimer interface [polypeptide binding]; other site
447217010654	ABC-ATPase subunit interface; other site
447217010655	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
447217010656	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
447217010657	Walker A/P-loop; other site
447217010658	ATP binding site [chemical binding]; other site
447217010659	Q-loop/lid; other site
447217010660	ABC transporter signature motif; other site
447217010661	Walker B; other site
447217010662	D-loop; other site
447217010663	H-loop/switch region; other site
447217010664	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217010665	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
447217010666	[4Fe-4S] binding site [ion binding]; other site
447217010667	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217010668	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217010669	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217010670	molybdopterin cofactor binding site; other site
447217010671	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
447217010672	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
447217010673	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
447217010674	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217010675	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217010676	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
447217010677	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
447217010678	short chain dehydrogenase; Provisional; Region: PRK08278
447217010679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010680	NAD(P) binding site [chemical binding]; other site
447217010681	active site
447217010682	cell division protein MraZ; Reviewed; Region: PRK00326
447217010683	MraZ protein; Region: MraZ; pfam02381
447217010684	MraZ protein; Region: MraZ; pfam02381
447217010685	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
447217010686	MraW methylase family; Region: Methyltransf_5; cl17771
447217010687	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
447217010688	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
447217010689	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
447217010690	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
447217010691	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
447217010692	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
447217010693	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010695	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010696	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
447217010697	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010698	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010699	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
447217010700	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
447217010701	Mg++ binding site [ion binding]; other site
447217010702	putative catalytic motif [active]
447217010703	putative substrate binding site [chemical binding]; other site
447217010704	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
447217010705	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
447217010706	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010707	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010708	cell division protein FtsW; Region: ftsW; TIGR02614
447217010709	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
447217010710	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
447217010711	active site
447217010712	homodimer interface [polypeptide binding]; other site
447217010713	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
447217010714	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010715	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010716	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010717	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652
447217010718	FAD binding domain; Region: FAD_binding_4; pfam01565
447217010719	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
447217010720	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
447217010721	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
447217010722	ATP-grasp domain; Region: ATP-grasp_4; cl17255
447217010723	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217010724	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217010725	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217010726	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
447217010727	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
447217010728	Cell division protein FtsQ; Region: FtsQ; pfam03799
447217010729	cell division protein FtsA; Region: ftsA; TIGR01174
447217010730	Cell division protein FtsA; Region: FtsA; smart00842
447217010731	Cell division protein FtsA; Region: FtsA; pfam14450
447217010732	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
447217010733	cell division protein FtsZ; Validated; Region: PRK09330
447217010734	nucleotide binding site [chemical binding]; other site
447217010735	SulA interaction site; other site
447217010736	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
447217010737	Putative esterase; Region: Esterase; pfam00756
447217010738	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
447217010739	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
447217010740	motif 1; other site
447217010741	active site
447217010742	motif 2; other site
447217010743	motif 3; other site
447217010744	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
447217010745	DHHA1 domain; Region: DHHA1; pfam02272
447217010746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217010747	S-adenosylmethionine binding site [chemical binding]; other site
447217010748	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217010749	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217010750	Walker A/P-loop; other site
447217010751	ATP binding site [chemical binding]; other site
447217010752	Q-loop/lid; other site
447217010753	ABC transporter signature motif; other site
447217010754	Walker B; other site
447217010755	D-loop; other site
447217010756	H-loop/switch region; other site
447217010757	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
447217010758	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217010759	catalytic residue [active]
447217010760	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217010761	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
447217010762	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
447217010763	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
447217010764	FMN binding site [chemical binding]; other site
447217010765	active site
447217010766	catalytic residues [active]
447217010767	substrate binding site [chemical binding]; other site
447217010768	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
447217010769	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
447217010770	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
447217010771	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217010772	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
447217010773	DNA binding residues [nucleotide binding]
447217010774	dimerization interface [polypeptide binding]; other site
447217010775	putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900
447217010776	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217010777	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217010778	protein binding site [polypeptide binding]; other site
447217010779	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
447217010780	Catalytic dyad [active]
447217010781	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
447217010782	Ligand Binding Site [chemical binding]; other site
447217010783	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
447217010784	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
447217010785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217010786	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
447217010787	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217010788	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
447217010789	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
447217010790	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
447217010791	metal binding site 2 [ion binding]; metal-binding site
447217010792	putative DNA binding helix; other site
447217010793	metal binding site 1 [ion binding]; metal-binding site
447217010794	dimer interface [polypeptide binding]; other site
447217010795	structural Zn2+ binding site [ion binding]; other site
447217010796	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
447217010797	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
447217010798	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
447217010799	dimer interface [polypeptide binding]; other site
447217010800	ssDNA binding site [nucleotide binding]; other site
447217010801	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217010802	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
447217010803	TPR repeat; Region: TPR_11; pfam13414
447217010804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217010805	binding surface
447217010806	TPR motif; other site
447217010807	TPR repeat; Region: TPR_11; pfam13414
447217010808	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
447217010809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217010810	motif II; other site
447217010811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217010812	dimerization interface [polypeptide binding]; other site
447217010813	putative DNA binding site [nucleotide binding]; other site
447217010814	putative Zn2+ binding site [ion binding]; other site
447217010815	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
447217010816	putative hydrophobic ligand binding site [chemical binding]; other site
447217010817	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
447217010818	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
447217010819	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
447217010820	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
447217010821	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
447217010822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
447217010823	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
447217010824	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
447217010825	active site
447217010826	dimer interface [polypeptide binding]; other site
447217010827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
447217010828	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
447217010829	Helix-turn-helix domain; Region: HTH_18; pfam12833
447217010830	Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004
447217010831	Family description; Region: VCBS; pfam13517
447217010832	Family description; Region: VCBS; pfam13517
447217010833	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
447217010834	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217010835	hypothetical protein; Reviewed; Region: PRK00024
447217010836	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
447217010837	MPN+ (JAMM) motif; other site
447217010838	Zinc-binding site [ion binding]; other site
447217010839	Peptidase family C69; Region: Peptidase_C69; cl17793
447217010840	Uncharacterized conserved protein [Function unknown]; Region: COG2353
447217010841	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
447217010842	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
447217010843	metal binding site [ion binding]; metal-binding site
447217010844	putative dimer interface [polypeptide binding]; other site
447217010845	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
447217010846	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
447217010847	trimer interface [polypeptide binding]; other site
447217010848	active site
447217010849	substrate binding site [chemical binding]; other site
447217010850	CoA binding site [chemical binding]; other site
447217010851	succinyldiaminopimelate transaminase; Region: DapC; TIGR03537
447217010852	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217010853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010854	homodimer interface [polypeptide binding]; other site
447217010855	catalytic residue [active]
447217010856	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
447217010857	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
447217010858	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217010859	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217010860	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010861	glutathione s-transferase; Provisional; Region: PTZ00057
447217010862	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
447217010863	dimer interface [polypeptide binding]; other site
447217010864	N-terminal domain interface [polypeptide binding]; other site
447217010865	substrate binding pocket (H-site) [chemical binding]; other site
447217010866	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217010867	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217010868	P-loop; other site
447217010869	Magnesium ion binding site [ion binding]; other site
447217010870	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217010871	Magnesium ion binding site [ion binding]; other site
447217010872	HEAT repeats; Region: HEAT_2; pfam13646
447217010873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010874	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217010875	putative substrate translocation pore; other site
447217010876	FOG: CBS domain [General function prediction only]; Region: COG0517
447217010877	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217010878	Transporter associated domain; Region: CorC_HlyC; smart01091
447217010879	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
447217010880	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
447217010881	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
447217010882	putative active site [active]
447217010883	catalytic triad [active]
447217010884	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217010885	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010887	active site
447217010888	phosphorylation site [posttranslational modification]
447217010889	intermolecular recognition site; other site
447217010890	dimerization interface [polypeptide binding]; other site
447217010891	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
447217010892	protease TldD; Provisional; Region: tldD; PRK10735
447217010893	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
447217010894	TAP-like protein; Region: Abhydrolase_4; pfam08386
447217010895	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
447217010896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010897	NAD(P) binding site [chemical binding]; other site
447217010898	active site
447217010899	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
447217010900	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217010901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010902	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217010903	DNA binding residues [nucleotide binding]
447217010904	seryl-tRNA synthetase; Provisional; Region: PRK05431
447217010905	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
447217010906	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
447217010907	dimer interface [polypeptide binding]; other site
447217010908	active site
447217010909	motif 1; other site
447217010910	motif 2; other site
447217010911	motif 3; other site
447217010912	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
447217010913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217010914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217010915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010916	dimer interface [polypeptide binding]; other site
447217010917	phosphorylation site [posttranslational modification]
447217010918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010919	ATP binding site [chemical binding]; other site
447217010920	Mg2+ binding site [ion binding]; other site
447217010921	G-X-G motif; other site
447217010922	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217010923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010924	active site
447217010925	phosphorylation site [posttranslational modification]
447217010926	intermolecular recognition site; other site
447217010927	dimerization interface [polypeptide binding]; other site
447217010928	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217010929	DNA binding site [nucleotide binding]
447217010930	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217010931	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217010932	Outer membrane efflux protein; Region: OEP; pfam02321
447217010933	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
447217010934	active site
447217010935	catalytic residues [active]
447217010936	Int/Topo IB signature motif; other site
447217010937	DNA binding site [nucleotide binding]
447217010938	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
447217010939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217010940	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
447217010941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217010942	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
447217010943	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217010944	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010945	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010946	active site
447217010947	ATP binding site [chemical binding]; other site
447217010948	substrate binding site [chemical binding]; other site
447217010949	activation loop (A-loop); other site
447217010950	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
447217010951	Z1 domain; Region: Z1; pfam10593
447217010952	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
447217010953	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
447217010954	AAA-like domain; Region: AAA_10; pfam12846
447217010955	PLD-like domain; Region: PLDc_2; pfam13091
447217010956	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
447217010957	homodimer interface [polypeptide binding]; other site
447217010958	putative active site [active]
447217010959	catalytic site [active]
447217010960	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217010961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010962	Walker A motif; other site
447217010963	ATP binding site [chemical binding]; other site
447217010964	Walker B motif; other site
447217010965	arginine finger; other site
447217010966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217010967	non-specific DNA binding site [nucleotide binding]; other site
447217010968	salt bridge; other site
447217010969	sequence-specific DNA binding site [nucleotide binding]; other site
447217010970	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
447217010971	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217010972	minor groove reading motif; other site
447217010973	helix-hairpin-helix signature motif; other site
447217010974	substrate binding pocket [chemical binding]; other site
447217010975	active site
447217010976	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
447217010977	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
447217010978	cofactor binding site; other site
447217010979	DNA binding site [nucleotide binding]
447217010980	substrate interaction site [chemical binding]; other site
447217010981	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
447217010982	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
447217010983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010984	ATP binding site [chemical binding]; other site
447217010985	Mg2+ binding site [ion binding]; other site
447217010986	G-X-G motif; other site
447217010987	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
447217010988	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
447217010989	cofactor binding site; other site
447217010990	DNA binding site [nucleotide binding]
447217010991	substrate interaction site [chemical binding]; other site
447217010992	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
447217010993	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
447217010994	active site
447217010995	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
447217010996	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
447217010997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217010998	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
447217010999	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217011000	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
447217011001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
447217011002	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217011003	active site
447217011004	metal binding site [ion binding]; metal-binding site
447217011005	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217011006	metal ion-dependent adhesion site (MIDAS); other site
447217011007	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
447217011008	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
447217011009	Walker A motif; other site
447217011010	ATP binding site [chemical binding]; other site
447217011011	Protein of unknown function (DUF429); Region: DUF429; cl12046
447217011012	Protein of unknown function DUF91; Region: DUF91; cl00709
447217011013	HNH endonuclease; Region: HNH_2; pfam13391
447217011014	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
447217011015	SnoaL-like domain; Region: SnoaL_2; pfam12680
447217011016	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
447217011017	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
447217011018	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217011019	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
447217011020	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
447217011021	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217011022	ATP binding site [chemical binding]; other site
447217011023	putative Mg++ binding site [ion binding]; other site
447217011024	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217011025	nucleotide binding region [chemical binding]; other site
447217011026	ATP-binding site [chemical binding]; other site
447217011027	DEAD/H associated; Region: DEAD_assoc; pfam08494
447217011028	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
447217011029	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
447217011030	Family description; Region: UvrD_C_2; pfam13538
447217011031	SEC-C motif; Region: SEC-C; pfam02810
447217011032	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
447217011033	HD domain; Region: HD_4; pfam13328
447217011034	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217011035	B12 binding domain; Region: B12-binding; pfam02310
447217011036	B12 binding site [chemical binding]; other site
447217011037	Radical SAM superfamily; Region: Radical_SAM; pfam04055
447217011038	hypothetical protein; Provisional; Region: PRK07546
447217011039	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
447217011040	substrate-cofactor binding pocket; other site
447217011041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217011042	catalytic residue [active]
447217011043	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
447217011044	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
447217011045	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
447217011046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011047	phosphorylation site [posttranslational modification]
447217011048	intermolecular recognition site; other site
447217011049	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
447217011050	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
447217011051	active site
447217011052	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
447217011053	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011054	dimerization interface [polypeptide binding]; other site
447217011055	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217011056	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217011057	dimer interface [polypeptide binding]; other site
447217011058	putative CheW interface [polypeptide binding]; other site
447217011059	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
447217011060	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
447217011061	active site
447217011062	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
447217011063	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217011064	active site
447217011065	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
447217011066	putative NADP binding site [chemical binding]; other site
447217011067	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
447217011068	active site
447217011069	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
447217011070	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217011071	active site
447217011072	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217011073	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
447217011074	active site
447217011075	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
447217011076	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
447217011077	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
447217011078	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217011079	Predicted transcriptional regulator [Transcription]; Region: COG2378
447217011080	HTH domain; Region: HTH_11; pfam08279
447217011081	WYL domain; Region: WYL; pfam13280
447217011082	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
447217011083	active site
447217011084	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
447217011085	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
447217011086	propionate/acetate kinase; Provisional; Region: PRK12379
447217011087	Uncharacterized conserved protein [Function unknown]; Region: COG3791
447217011088	RibD C-terminal domain; Region: RibD_C; cl17279
447217011089	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
447217011090	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
447217011091	Predicted permeases [General function prediction only]; Region: COG0701
447217011092	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
447217011093	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217011094	catalytic residues [active]
447217011095	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217011096	dimerization interface [polypeptide binding]; other site
447217011097	putative DNA binding site [nucleotide binding]; other site
447217011098	putative Zn2+ binding site [ion binding]; other site
447217011099	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
447217011100	arsenical-resistance protein; Region: acr3; TIGR00832
447217011101	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
447217011102	Low molecular weight phosphatase family; Region: LMWPc; cd00115
447217011103	active site
447217011104	RibD C-terminal domain; Region: RibD_C; cl17279
447217011105	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
447217011106	putative hydrophobic ligand binding site [chemical binding]; other site
447217011107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217011108	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
447217011109	Walker A/P-loop; other site
447217011110	ATP binding site [chemical binding]; other site
447217011111	Q-loop/lid; other site
447217011112	ABC transporter signature motif; other site
447217011113	Walker B; other site
447217011114	D-loop; other site
447217011115	H-loop/switch region; other site
447217011116	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
447217011117	ABC-2 type transporter; Region: ABC2_membrane; cl17235
447217011118	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
447217011119	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
447217011120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217011121	Walker A/P-loop; other site
447217011122	ATP binding site [chemical binding]; other site
447217011123	Q-loop/lid; other site
447217011124	ABC transporter signature motif; other site
447217011125	Walker B; other site
447217011126	D-loop; other site
447217011127	H-loop/switch region; other site
447217011128	ABC transporter; Region: ABC_tran_2; pfam12848
447217011129	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217011130	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217011131	putative dimer interface [polypeptide binding]; other site
447217011132	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217011133	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
447217011134	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
447217011135	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
447217011136	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
447217011137	benzoate transport; Region: 2A0115; TIGR00895
447217011138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011139	putative substrate translocation pore; other site
447217011140	RmuC family; Region: RmuC; pfam02646
447217011141	WYL domain; Region: WYL; pfam13280
447217011142	WYL domain; Region: WYL; pfam13280
447217011143	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217011144	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217011145	putative acyl-acceptor binding pocket; other site
447217011146	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217011147	Amidase; Region: Amidase; cl11426
447217011148	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
447217011149	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
447217011150	putative DNA binding site [nucleotide binding]; other site
447217011151	catalytic residue [active]
447217011152	putative H2TH interface [polypeptide binding]; other site
447217011153	putative catalytic residues [active]
447217011154	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217011155	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217011156	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
447217011157	Malic enzyme, N-terminal domain; Region: malic; pfam00390
447217011158	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
447217011159	putative NAD(P) binding site [chemical binding]; other site
447217011160	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
447217011161	homoserine dehydrogenase; Provisional; Region: PRK06270
447217011162	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
447217011163	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217011164	Domain of unknown function DUF302; Region: DUF302; pfam03625
447217011165	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217011166	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217011167	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217011168	FtsX-like permease family; Region: FtsX; pfam02687
447217011169	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217011170	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217011171	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217011172	Walker A/P-loop; other site
447217011173	ATP binding site [chemical binding]; other site
447217011174	Q-loop/lid; other site
447217011175	ABC transporter signature motif; other site
447217011176	Walker B; other site
447217011177	D-loop; other site
447217011178	H-loop/switch region; other site
447217011179	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
447217011180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
447217011181	Smr domain; Region: Smr; pfam01713
447217011182	Outer membrane efflux protein; Region: OEP; pfam02321
447217011183	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217011184	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217011185	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217011186	Protein export membrane protein; Region: SecD_SecF; cl14618
447217011187	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
447217011188	MgtE intracellular N domain; Region: MgtE_N; smart00924
447217011189	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
447217011190	Divalent cation transporter; Region: MgtE; pfam01769
447217011191	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
447217011192	phosphate binding site [ion binding]; other site
447217011193	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217011194	prolyl-tRNA synthetase; Provisional; Region: PRK09194
447217011195	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
447217011196	dimer interface [polypeptide binding]; other site
447217011197	motif 1; other site
447217011198	active site
447217011199	motif 2; other site
447217011200	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
447217011201	putative deacylase active site [active]
447217011202	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
447217011203	active site
447217011204	motif 3; other site
447217011205	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
447217011206	anticodon binding site; other site
447217011207	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
447217011208	GcpE protein; Region: GcpE; pfam04551
447217011209	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
447217011210	Thioredoxin; Region: Thioredoxin_4; pfam13462
447217011211	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217011212	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
447217011213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
447217011214	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217011215	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
447217011216	trimer interface [polypeptide binding]; other site
447217011217	dimer interface [polypeptide binding]; other site
447217011218	putative active site [active]
447217011219	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
447217011220	CheW-like domain; Region: CheW; pfam01584
447217011221	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
447217011222	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
447217011223	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
447217011224	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
447217011225	Substrate binding site; other site
447217011226	Mg++ binding site; other site
447217011227	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
447217011228	active site
447217011229	substrate binding site [chemical binding]; other site
447217011230	CoA binding site [chemical binding]; other site
447217011231	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
447217011232	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
447217011233	glutaminase active site [active]
447217011234	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
447217011235	dimer interface [polypeptide binding]; other site
447217011236	active site
447217011237	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
447217011238	dimer interface [polypeptide binding]; other site
447217011239	active site
447217011240	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
447217011241	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
447217011242	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
447217011243	recombinase A; Provisional; Region: recA; PRK09354
447217011244	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
447217011245	hexamer interface [polypeptide binding]; other site
447217011246	Walker A motif; other site
447217011247	ATP binding site [chemical binding]; other site
447217011248	Walker B motif; other site
447217011249	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
447217011250	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
447217011251	MOFRL family; Region: MOFRL; pfam05161
447217011252	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
447217011253	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
447217011254	putative active site [active]
447217011255	substrate binding site [chemical binding]; other site
447217011256	putative cosubstrate binding site; other site
447217011257	catalytic site [active]
447217011258	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
447217011259	substrate binding site [chemical binding]; other site
447217011260	16S rRNA methyltransferase B; Provisional; Region: PRK14902
447217011261	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
447217011262	putative RNA binding site [nucleotide binding]; other site
447217011263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217011264	S-adenosylmethionine binding site [chemical binding]; other site
447217011265	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
447217011266	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
447217011267	substrate binding site [chemical binding]; other site
447217011268	hexamer interface [polypeptide binding]; other site
447217011269	metal binding site [ion binding]; metal-binding site
447217011270	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
447217011271	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
447217011272	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
447217011273	ligand binding site [chemical binding]; other site
447217011274	active site
447217011275	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011277	active site
447217011278	phosphorylation site [posttranslational modification]
447217011279	intermolecular recognition site; other site
447217011280	dimerization interface [polypeptide binding]; other site
447217011281	TMAO/DMSO reductase; Reviewed; Region: PRK05363
447217011282	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217011283	Moco binding site; other site
447217011284	metal coordination site [ion binding]; other site
447217011285	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
447217011286	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
447217011287	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
447217011288	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
447217011289	AAA domain; Region: AAA_33; pfam13671
447217011290	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
447217011291	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
447217011292	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
447217011293	Methyltransferase domain; Region: Methyltransf_32; pfam13679
447217011294	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
447217011295	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
447217011296	putative active site [active]
447217011297	catalytic site [active]
447217011298	putative metal binding site [ion binding]; other site
447217011299	Winged helix-turn helix; Region: HTH_29; pfam13551
447217011300	Homeodomain-like domain; Region: HTH_23; cl17451
447217011301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
447217011302	Integrase core domain; Region: rve; pfam00665
447217011303	Integrase core domain; Region: rve_3; pfam13683
447217011304	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217011305	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011306	active site
447217011307	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
447217011308	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217011309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
447217011310	Walker A/P-loop; other site
447217011311	ATP binding site [chemical binding]; other site
447217011312	Q-loop/lid; other site
447217011313	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217011314	ABC transporter signature motif; other site
447217011315	Walker B; other site
447217011316	D-loop; other site
447217011317	ABC transporter; Region: ABC_tran_2; pfam12848
447217011318	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
447217011319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011320	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217011321	putative substrate translocation pore; other site
447217011322	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
447217011323	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217011324	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
447217011325	putative metal binding site; other site
447217011326	PEGA domain; Region: PEGA; pfam08308
447217011327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217011328	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
447217011329	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
447217011330	Walker A/P-loop; other site
447217011331	ATP binding site [chemical binding]; other site
447217011332	Q-loop/lid; other site
447217011333	ABC transporter signature motif; other site
447217011334	Walker B; other site
447217011335	D-loop; other site
447217011336	H-loop/switch region; other site
447217011337	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
447217011338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011339	dimer interface [polypeptide binding]; other site
447217011340	conserved gate region; other site
447217011341	ABC-ATPase subunit interface; other site
447217011342	NMT1-like family; Region: NMT1_2; pfam13379
447217011343	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
447217011344	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
447217011345	NlpC/P60 family; Region: NLPC_P60; cl17555
447217011346	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
447217011347	active site
447217011348	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
447217011349	PhoU domain; Region: PhoU; pfam01895
447217011350	PhoU domain; Region: PhoU; pfam01895
447217011351	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
447217011352	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
447217011353	Walker A/P-loop; other site
447217011354	ATP binding site [chemical binding]; other site
447217011355	Q-loop/lid; other site
447217011356	ABC transporter signature motif; other site
447217011357	Walker B; other site
447217011358	D-loop; other site
447217011359	H-loop/switch region; other site
447217011360	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
447217011361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011362	dimer interface [polypeptide binding]; other site
447217011363	conserved gate region; other site
447217011364	putative PBP binding loops; other site
447217011365	ABC-ATPase subunit interface; other site
447217011366	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
447217011367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011368	dimer interface [polypeptide binding]; other site
447217011369	conserved gate region; other site
447217011370	putative PBP binding loops; other site
447217011371	ABC-ATPase subunit interface; other site
447217011372	PBP superfamily domain; Region: PBP_like_2; cl17296
447217011373	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217011374	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
447217011375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011376	dimer interface [polypeptide binding]; other site
447217011377	phosphorylation site [posttranslational modification]
447217011378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011379	ATP binding site [chemical binding]; other site
447217011380	Mg2+ binding site [ion binding]; other site
447217011381	G-X-G motif; other site
447217011382	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217011383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011384	active site
447217011385	phosphorylation site [posttranslational modification]
447217011386	intermolecular recognition site; other site
447217011387	dimerization interface [polypeptide binding]; other site
447217011388	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217011389	DNA binding site [nucleotide binding]
447217011390	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217011391	ligand binding site [chemical binding]; other site
447217011392	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
447217011393	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217011394	metal binding site [ion binding]; metal-binding site
447217011395	active site
447217011396	I-site; other site
447217011397	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
447217011398	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
447217011399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
447217011400	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217011401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011402	putative substrate translocation pore; other site
447217011403	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217011404	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011405	active site
447217011406	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
447217011407	CoenzymeA binding site [chemical binding]; other site
447217011408	subunit interaction site [polypeptide binding]; other site
447217011409	PHB binding site; other site
447217011410	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
447217011411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011412	POT family; Region: PTR2; cl17359
447217011413	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217011414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011415	putative substrate translocation pore; other site
447217011416	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217011417	active site residue [active]
447217011418	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
447217011419	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
447217011420	aromatic arch; other site
447217011421	DCoH dimer interaction site [polypeptide binding]; other site
447217011422	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
447217011423	DCoH tetramer interaction site [polypeptide binding]; other site
447217011424	substrate binding site [chemical binding]; other site
447217011425	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
447217011426	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217011427	putative active site [active]
447217011428	putative metal binding site [ion binding]; other site
447217011429	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217011430	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
447217011431	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
447217011432	NAD-dependent deacetylase; Provisional; Region: PRK00481
447217011433	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
447217011434	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217011435	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
447217011436	intersubunit interface [polypeptide binding]; other site
447217011437	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
447217011438	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217011439	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
447217011440	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
447217011441	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
447217011442	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
447217011443	active site
447217011444	catalytic site [active]
447217011445	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
447217011446	active site
447217011447	catalytic site [active]
447217011448	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
447217011449	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217011450	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
447217011451	catalytic residues [active]
447217011452	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217011453	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217011454	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011455	active site
447217011456	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
447217011457	pyruvate phosphate dikinase; Provisional; Region: PRK09279
447217011458	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
447217011459	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
447217011460	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
447217011461	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
447217011462	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
447217011463	Ligand Binding Site [chemical binding]; other site
447217011464	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217011465	CPxP  motif; other site
447217011466	Thioredoxin; Region: Thioredoxin_4; pfam13462
447217011467	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217011468	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217011469	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217011470	Thioredoxin; Region: Thioredoxin_4; pfam13462
447217011471	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217011472	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
447217011473	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
447217011474	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
447217011475	tetramerization interface [polypeptide binding]; other site
447217011476	active site
447217011477	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
447217011478	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
447217011479	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
447217011480	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
447217011481	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
447217011482	glutamine binding [chemical binding]; other site
447217011483	catalytic triad [active]
447217011484	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
447217011485	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
447217011486	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
447217011487	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
447217011488	active site
447217011489	ribulose/triose binding site [chemical binding]; other site
447217011490	phosphate binding site [ion binding]; other site
447217011491	substrate (anthranilate) binding pocket [chemical binding]; other site
447217011492	product (indole) binding pocket [chemical binding]; other site
447217011493	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
447217011494	active site
447217011495	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
447217011496	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
447217011497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217011498	catalytic residue [active]
447217011499	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
447217011500	substrate binding site [chemical binding]; other site
447217011501	active site
447217011502	catalytic residues [active]
447217011503	heterodimer interface [polypeptide binding]; other site
447217011504	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
447217011505	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
447217011506	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217011507	PGAP1-like protein; Region: PGAP1; pfam07819
447217011508	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
447217011509	MarR family; Region: MarR_2; cl17246
447217011510	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
447217011511	EamA-like transporter family; Region: EamA; pfam00892
447217011512	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217011513	EamA-like transporter family; Region: EamA; pfam00892
447217011514	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
447217011515	active site
447217011516	intersubunit interactions; other site
447217011517	catalytic residue [active]
447217011518	KpsF/GutQ family protein; Region: kpsF; TIGR00393
447217011519	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
447217011520	putative active site [active]
447217011521	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
447217011522	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
447217011523	intersubunit interface [polypeptide binding]; other site
447217011524	active site
447217011525	Zn2+ binding site [ion binding]; other site
447217011526	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
447217011527	catalytic center binding site [active]
447217011528	ATP binding site [chemical binding]; other site
447217011529	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
447217011530	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
447217011531	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
447217011532	dihydrodipicolinate reductase; Provisional; Region: PRK00048
447217011533	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
447217011534	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
447217011535	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
447217011536	dihydrodipicolinate synthase; Region: dapA; TIGR00674
447217011537	dimer interface [polypeptide binding]; other site
447217011538	active site
447217011539	catalytic residue [active]
447217011540	diaminopimelate decarboxylase; Region: lysA; TIGR01048
447217011541	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
447217011542	active site
447217011543	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217011544	substrate binding site [chemical binding]; other site
447217011545	catalytic residues [active]
447217011546	dimer interface [polypeptide binding]; other site
447217011547	argininosuccinate lyase; Provisional; Region: PRK00855
447217011548	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
447217011549	active sites [active]
447217011550	tetramer interface [polypeptide binding]; other site
447217011551	OsmC-like protein; Region: OsmC; pfam02566
447217011552	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217011553	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
447217011554	dimer interface [polypeptide binding]; other site
447217011555	substrate binding site [chemical binding]; other site
447217011556	metal binding site [ion binding]; metal-binding site
447217011557	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
447217011558	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
447217011559	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
447217011560	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
447217011561	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
447217011562	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011563	active site
447217011564	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011565	active site
447217011566	Protein of unknown function (DUF938); Region: DUF938; pfam06080
447217011567	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217011568	HSP70 interaction site [polypeptide binding]; other site
447217011569	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
447217011570	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
447217011571	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
447217011572	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
447217011573	NAD(P) binding site [chemical binding]; other site
447217011574	Rib/alpha-like repeat; Region: Rib; cl07159
447217011575	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217011576	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011577	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217011578	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217011579	active site
447217011580	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217011581	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
447217011582	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
447217011583	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217011585	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217011586	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217011587	active site
447217011588	ATP binding site [chemical binding]; other site
447217011589	substrate binding site [chemical binding]; other site
447217011590	activation loop (A-loop); other site
447217011591	multifunctional aminopeptidase A; Provisional; Region: PRK00913
447217011592	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
447217011593	interface (dimer of trimers) [polypeptide binding]; other site
447217011594	Substrate-binding/catalytic site; other site
447217011595	Zn-binding sites [ion binding]; other site
447217011596	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
447217011597	dimer interface [polypeptide binding]; other site
447217011598	substrate binding site [chemical binding]; other site
447217011599	metal binding sites [ion binding]; metal-binding site
447217011600	Hemerythrin; Region: Hemerythrin; cd12107
447217011601	Fe binding site [ion binding]; other site
447217011602	Arginase family; Region: Arginase; pfam00491
447217011603	active site
447217011604	metal binding site [ion binding]; metal-binding site
447217011605	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
447217011606	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217011607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217011608	homodimer interface [polypeptide binding]; other site
447217011609	catalytic residue [active]
447217011610	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217011611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217011612	short chain dehydrogenase; Provisional; Region: PRK06500
447217011613	classical (c) SDRs; Region: SDR_c; cd05233
447217011614	NAD(P) binding site [chemical binding]; other site
447217011615	active site
447217011616	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217011617	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
447217011618	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217011619	Outer membrane efflux protein; Region: OEP; pfam02321
447217011620	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
447217011621	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
447217011622	MarR family; Region: MarR; pfam01047
447217011623	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
447217011624	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
447217011625	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011626	active site
447217011627	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
447217011628	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
447217011629	putative active site [active]
447217011630	putative CoA binding site [chemical binding]; other site
447217011631	nudix motif; other site
447217011632	metal binding site [ion binding]; metal-binding site
447217011633	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217011634	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217011635	active site
447217011636	active site
447217011637	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
447217011638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011639	active site
447217011640	phosphorylation site [posttranslational modification]
447217011641	intermolecular recognition site; other site
447217011642	dimerization interface [polypeptide binding]; other site
447217011643	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
447217011644	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
447217011645	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217011646	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217011647	active site
447217011648	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217011649	lipoyl attachment site [posttranslational modification]; other site
447217011650	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011652	active site
447217011653	phosphorylation site [posttranslational modification]
447217011654	intermolecular recognition site; other site
447217011655	dimerization interface [polypeptide binding]; other site
447217011656	PAS fold; Region: PAS; pfam00989
447217011657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217011658	putative active site [active]
447217011659	heme pocket [chemical binding]; other site
447217011660	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217011661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011662	dimer interface [polypeptide binding]; other site
447217011663	phosphorylation site [posttranslational modification]
447217011664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011665	ATP binding site [chemical binding]; other site
447217011666	Mg2+ binding site [ion binding]; other site
447217011667	G-X-G motif; other site
447217011668	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217011669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011670	dimerization interface [polypeptide binding]; other site
447217011671	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011672	dimerization interface [polypeptide binding]; other site
447217011673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011674	dimerization interface [polypeptide binding]; other site
447217011675	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011676	dimerization interface [polypeptide binding]; other site
447217011677	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217011678	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011679	dimerization interface [polypeptide binding]; other site
447217011680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011681	dimerization interface [polypeptide binding]; other site
447217011682	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
447217011683	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011684	dimerization interface [polypeptide binding]; other site
447217011685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011686	dimerization interface [polypeptide binding]; other site
447217011687	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011688	dimerization interface [polypeptide binding]; other site
447217011689	HAMP domain; Region: HAMP; pfam00672
447217011690	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011691	dimerization interface [polypeptide binding]; other site
447217011692	GAF domain; Region: GAF_2; pfam13185
447217011693	GAF domain; Region: GAF_3; pfam13492
447217011694	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011695	dimer interface [polypeptide binding]; other site
447217011696	phosphorylation site [posttranslational modification]
447217011697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011698	ATP binding site [chemical binding]; other site
447217011699	Mg2+ binding site [ion binding]; other site
447217011700	G-X-G motif; other site
447217011701	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217011702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011703	active site
447217011704	phosphorylation site [posttranslational modification]
447217011705	intermolecular recognition site; other site
447217011706	dimerization interface [polypeptide binding]; other site
447217011707	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
447217011708	SnoaL-like domain; Region: SnoaL_3; pfam13474
447217011709	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217011710	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
447217011711	Ca binding site [ion binding]; other site
447217011712	active site
447217011713	catalytic site [active]
447217011714	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
447217011715	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011716	active site
447217011717	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
447217011718	carbohydrate binding site [chemical binding]; other site
447217011719	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
447217011720	trimer interface; other site
447217011721	sugar binding site [chemical binding]; other site
447217011722	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
447217011723	putative ligand binding site [chemical binding]; other site
447217011724	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
447217011725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011726	dimer interface [polypeptide binding]; other site
447217011727	conserved gate region; other site
447217011728	putative PBP binding loops; other site
447217011729	ABC-ATPase subunit interface; other site
447217011730	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
447217011731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011732	dimer interface [polypeptide binding]; other site
447217011733	conserved gate region; other site
447217011734	putative PBP binding loops; other site
447217011735	ABC-ATPase subunit interface; other site
447217011736	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
447217011737	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
447217011738	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
447217011739	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
447217011740	Walker A/P-loop; other site
447217011741	ATP binding site [chemical binding]; other site
447217011742	Q-loop/lid; other site
447217011743	ABC transporter signature motif; other site
447217011744	Walker B; other site
447217011745	D-loop; other site
447217011746	H-loop/switch region; other site
447217011747	TOBE domain; Region: TOBE_2; pfam08402
447217011748	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
447217011749	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217011750	active site
447217011751	catalytic site [active]
447217011752	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
447217011753	Uncharacterized conserved protein [Function unknown]; Region: COG3461
447217011754	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217011755	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
447217011756	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011758	active site
447217011759	phosphorylation site [posttranslational modification]
447217011760	intermolecular recognition site; other site
447217011761	dimerization interface [polypeptide binding]; other site
447217011762	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
447217011763	Predicted exporter [General function prediction only]; Region: COG4258
447217011764	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217011765	active site
447217011766	metal binding site [ion binding]; metal-binding site
447217011767	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217011768	putative acyl-acceptor binding pocket; other site
447217011769	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
447217011770	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
447217011771	putative acyl-acceptor binding pocket; other site
447217011772	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011773	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217011774	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
447217011775	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
447217011776	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
447217011777	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
447217011778	DoxX; Region: DoxX; pfam07681
447217011779	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217011780	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217011781	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
447217011782	HlyD family secretion protein; Region: HlyD_3; pfam13437
447217011783	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217011784	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
447217011785	Walker A/P-loop; other site
447217011786	ATP binding site [chemical binding]; other site
447217011787	Q-loop/lid; other site
447217011788	ABC transporter signature motif; other site
447217011789	Walker B; other site
447217011790	D-loop; other site
447217011791	H-loop/switch region; other site
447217011792	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217011793	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217011794	FtsX-like permease family; Region: FtsX; pfam02687
447217011795	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217011796	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217011797	FtsX-like permease family; Region: FtsX; pfam02687
447217011798	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
447217011799	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217011800	Catalytic site [active]
447217011801	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217011802	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
447217011803	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
447217011804	active site
447217011805	DNA binding site [nucleotide binding]
447217011806	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
447217011807	DNA binding site [nucleotide binding]
447217011808	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
447217011809	nickel binding site [ion binding]; other site
447217011810	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
447217011811	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
447217011812	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
447217011813	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
447217011814	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
447217011815	4Fe-4S binding domain; Region: Fer4; pfam00037
447217011816	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217011817	CPxP  motif; other site
447217011818	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
447217011819	active site
447217011820	phosphorylation site [posttranslational modification]
447217011821	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
447217011822	30S subunit binding site; other site
447217011823	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
447217011824	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
447217011825	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
447217011826	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
447217011827	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
447217011828	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
447217011829	Walker A/P-loop; other site
447217011830	ATP binding site [chemical binding]; other site
447217011831	Q-loop/lid; other site
447217011832	ABC transporter signature motif; other site
447217011833	Walker B; other site
447217011834	D-loop; other site
447217011835	H-loop/switch region; other site
447217011836	OstA-like protein; Region: OstA; cl00844
447217011837	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
447217011838	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
447217011839	putative acyl-acceptor binding pocket; other site
447217011840	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
447217011841	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
447217011842	CTP synthetase; Validated; Region: pyrG; PRK05380
447217011843	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
447217011844	Catalytic site [active]
447217011845	active site
447217011846	UTP binding site [chemical binding]; other site
447217011847	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
447217011848	active site
447217011849	putative oxyanion hole; other site
447217011850	catalytic triad [active]
447217011851	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
447217011852	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
447217011853	Ligand binding site; other site
447217011854	oligomer interface; other site
447217011855	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
447217011856	active site
447217011857	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
447217011858	homodimer interface [polypeptide binding]; other site
447217011859	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217011860	S4 RNA-binding domain; Region: S4; smart00363
447217011861	RNA binding surface [nucleotide binding]; other site
447217011862	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
447217011863	active site
447217011864	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
447217011865	GTPase CgtA; Reviewed; Region: obgE; PRK12299
447217011866	GTP1/OBG; Region: GTP1_OBG; pfam01018
447217011867	Obg GTPase; Region: Obg; cd01898
447217011868	G1 box; other site
447217011869	GTP/Mg2+ binding site [chemical binding]; other site
447217011870	Switch I region; other site
447217011871	G2 box; other site
447217011872	G3 box; other site
447217011873	Switch II region; other site
447217011874	G4 box; other site
447217011875	G5 box; other site
447217011876	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
447217011877	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
447217011878	Uncharacterized conserved protein [Function unknown]; Region: COG3339
447217011879	Inward rectifier potassium channel; Region: IRK; pfam01007
447217011880	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
447217011881	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
447217011882	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
447217011883	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
447217011884	GatB domain; Region: GatB_Yqey; smart00845
447217011885	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217011886	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
447217011887	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
447217011888	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
447217011889	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
447217011890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217011891	TPR motif; other site
447217011892	TPR repeat; Region: TPR_11; pfam13414
447217011893	binding surface
447217011894	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
447217011895	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
447217011896	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
447217011897	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
447217011898	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
447217011899	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
447217011900	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
447217011901	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217011902	ligand binding site [chemical binding]; other site
447217011903	membrane protein; Provisional; Region: PRK14400
447217011904	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
447217011905	Yip1 domain; Region: Yip1; pfam04893
447217011906	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
447217011907	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
447217011908	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
447217011909	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
447217011910	SLBB domain; Region: SLBB; pfam10531
447217011911	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
447217011912	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
447217011913	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
447217011914	putative dimer interface [polypeptide binding]; other site
447217011915	[2Fe-2S] cluster binding site [ion binding]; other site
447217011916	PilZ domain; Region: PilZ; cl01260
447217011917	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011919	active site
447217011920	phosphorylation site [posttranslational modification]
447217011921	intermolecular recognition site; other site
447217011922	dimerization interface [polypeptide binding]; other site
447217011923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
447217011924	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
447217011925	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217011926	IHF - DNA interface [nucleotide binding]; other site
447217011927	IHF dimer interface [polypeptide binding]; other site
447217011928	PilZ domain; Region: PilZ; pfam07238
447217011929	amidophosphoribosyltransferase; Provisional; Region: PRK09123
447217011930	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
447217011931	active site
447217011932	tetramer interface [polypeptide binding]; other site
447217011933	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217011934	active site
447217011935	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
447217011936	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011937	active site
447217011938	PEGA domain; Region: PEGA; pfam08308
447217011939	PilZ domain; Region: PilZ; cl01260
447217011940	PilZ domain; Region: PilZ; cl01260
447217011941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011942	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217011943	active site
447217011944	phosphorylation site [posttranslational modification]
447217011945	intermolecular recognition site; other site
447217011946	dimerization interface [polypeptide binding]; other site
447217011947	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
447217011948	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
447217011949	dimerization interface [polypeptide binding]; other site
447217011950	ATP binding site [chemical binding]; other site
447217011951	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
447217011952	dimerization interface [polypeptide binding]; other site
447217011953	ATP binding site [chemical binding]; other site
447217011954	RNase_H superfamily; Region: RNase_H_2; pfam13482
447217011955	Part of AAA domain; Region: AAA_19; pfam13245
447217011956	AAA domain; Region: AAA_12; pfam13087
447217011957	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217011958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011959	dimer interface [polypeptide binding]; other site
447217011960	phosphorylation site [posttranslational modification]
447217011961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011962	ATP binding site [chemical binding]; other site
447217011963	Mg2+ binding site [ion binding]; other site
447217011964	G-X-G motif; other site
447217011965	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011967	active site
447217011968	phosphorylation site [posttranslational modification]
447217011969	intermolecular recognition site; other site
447217011970	dimerization interface [polypeptide binding]; other site
447217011971	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
447217011972	active site
447217011973	Smr domain; Region: Smr; pfam01713
447217011974	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
447217011975	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
447217011976	30S subunit binding site; other site
447217011977	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011979	active site
447217011980	phosphorylation site [posttranslational modification]
447217011981	intermolecular recognition site; other site
447217011982	dimerization interface [polypeptide binding]; other site
447217011983	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217011984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011985	dimer interface [polypeptide binding]; other site
447217011986	phosphorylation site [posttranslational modification]
447217011987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011988	ATP binding site [chemical binding]; other site
447217011989	G-X-G motif; other site
447217011990	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217011991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011992	active site
447217011993	phosphorylation site [posttranslational modification]
447217011994	intermolecular recognition site; other site
447217011995	dimerization interface [polypeptide binding]; other site
447217011996	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217011997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011998	ATP binding site [chemical binding]; other site
447217011999	Mg2+ binding site [ion binding]; other site
447217012000	G-X-G motif; other site
447217012001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217012002	dimerization interface [polypeptide binding]; other site
447217012003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217012004	phosphorylation site [posttranslational modification]
447217012005	dimer interface [polypeptide binding]; other site
447217012006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012007	ATP binding site [chemical binding]; other site
447217012008	Mg2+ binding site [ion binding]; other site
447217012009	G-X-G motif; other site
447217012010	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
447217012011	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
447217012012	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
447217012013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217012014	FeS/SAM binding site; other site
447217012015	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
447217012016	active site
447217012017	DNA binding site [nucleotide binding]
447217012018	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
447217012019	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
447217012020	domain interfaces; other site
447217012021	active site
447217012022	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
447217012023	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
447217012024	active site
447217012025	NUDIX domain; Region: NUDIX; pfam00293
447217012026	nudix motif; other site
447217012027	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217012028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
447217012029	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217012030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217012031	active site
447217012032	phosphorylation site [posttranslational modification]
447217012033	intermolecular recognition site; other site
447217012034	dimerization interface [polypeptide binding]; other site
447217012035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217012036	Walker A motif; other site
447217012037	ATP binding site [chemical binding]; other site
447217012038	Walker B motif; other site
447217012039	arginine finger; other site
447217012040	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217012041	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217012042	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217012043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217012044	Walker A motif; other site
447217012045	ATP binding site [chemical binding]; other site
447217012046	Walker B motif; other site
447217012047	arginine finger; other site
447217012048	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217012049	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
447217012050	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
447217012051	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
447217012052	putative active site [active]
447217012053	catalytic site [active]
447217012054	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
447217012055	putative active site [active]
447217012056	catalytic site [active]
447217012057	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
447217012058	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
447217012059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217012060	dimerization interface [polypeptide binding]; other site
447217012061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217012062	dimer interface [polypeptide binding]; other site
447217012063	phosphorylation site [posttranslational modification]
447217012064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012065	ATP binding site [chemical binding]; other site
447217012066	Mg2+ binding site [ion binding]; other site
447217012067	G-X-G motif; other site
447217012068	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
447217012069	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
447217012070	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
447217012071	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
447217012072	Nitrogen regulatory protein P-II; Region: P-II; smart00938
447217012073	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217012074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217012075	dimer interface [polypeptide binding]; other site
447217012076	phosphorylation site [posttranslational modification]
447217012077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012078	ATP binding site [chemical binding]; other site
447217012079	Mg2+ binding site [ion binding]; other site
447217012080	G-X-G motif; other site
447217012081	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217012082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217012083	active site
447217012084	phosphorylation site [posttranslational modification]
447217012085	intermolecular recognition site; other site
447217012086	dimerization interface [polypeptide binding]; other site
447217012087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217012088	Walker A motif; other site
447217012089	ATP binding site [chemical binding]; other site
447217012090	Walker B motif; other site
447217012091	arginine finger; other site
447217012092	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
447217012093	glutamine synthetase, type I; Region: GlnA; TIGR00653
447217012094	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
447217012095	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
447217012096	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
447217012097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217012098	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217012099	putative substrate translocation pore; other site
447217012100	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
447217012101	Transposase domain (DUF772); Region: DUF772; pfam05598
447217012102	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217012103	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
447217012104	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217012105	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
447217012106	Walker A/P-loop; other site
447217012107	ATP binding site [chemical binding]; other site
447217012108	Q-loop/lid; other site
447217012109	ABC transporter signature motif; other site
447217012110	Walker B; other site
447217012111	D-loop; other site
447217012112	H-loop/switch region; other site
447217012113	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217012114	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
447217012115	Walker A/P-loop; other site
447217012116	ATP binding site [chemical binding]; other site
447217012117	Q-loop/lid; other site
447217012118	ABC transporter signature motif; other site
447217012119	Walker B; other site
447217012120	D-loop; other site
447217012121	H-loop/switch region; other site
447217012122	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
447217012123	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217012124	TM-ABC transporter signature motif; other site
447217012125	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
447217012126	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217012127	TM-ABC transporter signature motif; other site
447217012128	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
447217012129	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
447217012130	putative ligand binding site [chemical binding]; other site
447217012131	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
447217012132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217012133	active site
447217012134	phosphorylation site [posttranslational modification]
447217012135	intermolecular recognition site; other site
447217012136	dimerization interface [polypeptide binding]; other site
447217012137	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217012138	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
447217012139	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
447217012140	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
447217012141	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
447217012142	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
447217012143	Protein of unknown function DUF58; Region: DUF58; pfam01882
447217012144	MoxR-like ATPases [General function prediction only]; Region: COG0714
447217012145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217012146	Walker A motif; other site
447217012147	ATP binding site [chemical binding]; other site
447217012148	Walker B motif; other site
447217012149	arginine finger; other site
447217012150	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
447217012151	Zn binding site [ion binding]; other site
447217012152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217012153	TPR motif; other site
447217012154	binding surface
447217012155	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
447217012156	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217012157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217012158	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217012159	DNA binding residues [nucleotide binding]
447217012160	tyrosine kinase; Provisional; Region: PRK11519
447217012161	Chain length determinant protein; Region: Wzz; pfam02706
447217012162	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
447217012163	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217012164	Nucleotide binding site [chemical binding]; other site
447217012165	P loop; other site
447217012166	DTAP/Switch II; other site
447217012167	Switch I; other site
447217012168	polysaccharide export protein Wza; Provisional; Region: PRK15078
447217012169	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217012170	Low molecular weight phosphatase family; Region: LMWPc; cd00115
447217012171	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
447217012172	active site
447217012173	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
447217012174	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
447217012175	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
447217012176	NAD(P) binding site [chemical binding]; other site
447217012177	homodimer interface [polypeptide binding]; other site
447217012178	substrate binding site [chemical binding]; other site
447217012179	active site
447217012180	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
447217012181	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
447217012182	putative trimer interface [polypeptide binding]; other site
447217012183	putative CoA binding site [chemical binding]; other site
447217012184	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
447217012185	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217012186	putative ADP-binding pocket [chemical binding]; other site
447217012187	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217012188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217012189	NAD(P) binding site [chemical binding]; other site
447217012190	active site
447217012191	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
447217012192	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
447217012193	Mg++ binding site [ion binding]; other site
447217012194	putative catalytic motif [active]
447217012195	putative substrate binding site [chemical binding]; other site
447217012196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217012197	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217012198	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217012199	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217012200	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
447217012201	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
447217012202	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217012203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217012204	NAD(P) binding site [chemical binding]; other site
447217012205	active site
447217012206	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217012207	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
447217012208	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
447217012209	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
447217012210	NAD binding site [chemical binding]; other site
447217012211	substrate binding site [chemical binding]; other site
447217012212	homodimer interface [polypeptide binding]; other site
447217012213	active site
447217012214	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217012215	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
447217012216	putative ADP-binding pocket [chemical binding]; other site
447217012217	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
447217012218	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
447217012219	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
447217012220	NADP binding site [chemical binding]; other site
447217012221	active site
447217012222	putative substrate binding site [chemical binding]; other site
447217012223	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
447217012224	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
447217012225	NADP-binding site; other site
447217012226	homotetramer interface [polypeptide binding]; other site
447217012227	substrate binding site [chemical binding]; other site
447217012228	homodimer interface [polypeptide binding]; other site
447217012229	active site
447217012230	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
447217012231	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
447217012232	NAD binding site [chemical binding]; other site
447217012233	substrate binding site [chemical binding]; other site
447217012234	homodimer interface [polypeptide binding]; other site
447217012235	active site
447217012236	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
447217012237	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
447217012238	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
447217012239	substrate binding site; other site
447217012240	tetramer interface; other site
447217012241	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
447217012242	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
447217012243	NADP binding site [chemical binding]; other site
447217012244	active site
447217012245	putative substrate binding site [chemical binding]; other site
447217012246	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217012247	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
447217012248	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217012249	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
447217012250	Domain of unknown function (DUF222); Region: DUF222; pfam02720
447217012251	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217012252	active site
447217012253	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
447217012254	Ligand binding site; other site
447217012255	Putative Catalytic site; other site
447217012256	DXD motif; other site
447217012257	Methyltransferase domain; Region: Methyltransf_23; pfam13489
447217012258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217012259	S-adenosylmethionine binding site [chemical binding]; other site
447217012260	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
447217012261	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217012262	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
447217012263	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217012264	metal-binding site
447217012265	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
447217012266	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217012267	active site
447217012268	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
447217012269	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
447217012270	active site
447217012271	homodimer interface [polypeptide binding]; other site
447217012272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217012273	TIGR01777 family protein; Region: yfcH
447217012274	NAD(P) binding site [chemical binding]; other site
447217012275	active site
447217012276	peptide chain release factor 1; Provisional; Region: PRK04011
447217012277	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
447217012278	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217012279	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
447217012280	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
447217012281	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
447217012282	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
447217012283	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
447217012284	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
447217012285	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
447217012286	PAS domain; Region: PAS_9; pfam13426
447217012287	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
447217012288	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217012289	dimer interface [polypeptide binding]; other site
447217012290	phosphorylation site [posttranslational modification]
447217012291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012292	ATP binding site [chemical binding]; other site
447217012293	Mg2+ binding site [ion binding]; other site
447217012294	G-X-G motif; other site
447217012295	Protein of unknown function DUF111; Region: DUF111; pfam01969
447217012296	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
447217012297	AIR carboxylase; Region: AIRC; smart01001
447217012298	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
447217012299	Chemotaxis phosphatase CheX; Region: CheX; cl15816
447217012300	CheC-like family; Region: CheC; pfam04509
447217012301	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217012302	putative binding surface; other site
447217012303	active site
447217012304	P2 response regulator binding domain; Region: P2; pfam07194
447217012305	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217012306	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217012307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012308	ATP binding site [chemical binding]; other site
447217012309	Mg2+ binding site [ion binding]; other site
447217012310	G-X-G motif; other site
447217012311	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217012312	Response regulator receiver domain; Region: Response_reg; pfam00072
447217012313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217012314	active site
447217012315	phosphorylation site [posttranslational modification]
447217012316	intermolecular recognition site; other site
447217012317	dimerization interface [polypeptide binding]; other site
447217012318	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217012319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217012320	dimerization interface [polypeptide binding]; other site
447217012321	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217012322	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217012323	dimer interface [polypeptide binding]; other site
447217012324	putative CheW interface [polypeptide binding]; other site
447217012325	thiamine monophosphate kinase; Provisional; Region: PRK05731
447217012326	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
447217012327	ATP binding site [chemical binding]; other site
447217012328	dimerization interface [polypeptide binding]; other site
447217012329	Sensory domain found in PocR; Region: PocR; pfam10114
447217012330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217012331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217012332	dimer interface [polypeptide binding]; other site
447217012333	phosphorylation site [posttranslational modification]
447217012334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217012335	ATP binding site [chemical binding]; other site
447217012336	Mg2+ binding site [ion binding]; other site
447217012337	G-X-G motif; other site
447217012338	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
447217012339	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217012340	G1 box; other site
447217012341	GTP/Mg2+ binding site [chemical binding]; other site
447217012342	G2 box; other site
447217012343	Switch I region; other site
447217012344	G3 box; other site
447217012345	Switch II region; other site
447217012346	G4 box; other site
447217012347	G5 box; other site
447217012348	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
447217012349	DEAD/DEAH box helicase; Region: DEAD; pfam00270
447217012350	ATP binding site [chemical binding]; other site
447217012351	DEAD_2; Region: DEAD_2; pfam06733
447217012352	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
447217012353	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
447217012354	Peptidase family M50; Region: Peptidase_M50; pfam02163
447217012355	active site
447217012356	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
447217012357	putative substrate binding region [chemical binding]; other site
447217012358	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
447217012359	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
447217012360	putative ligand binding site [chemical binding]; other site
447217012361	chaperone protein DnaJ; Provisional; Region: PRK10767
447217012362	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217012363	HSP70 interaction site [polypeptide binding]; other site
447217012364	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
447217012365	Zn binding sites [ion binding]; other site
447217012366	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
447217012367	dimer interface [polypeptide binding]; other site
447217012368	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217012369	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
447217012370	nucleotide binding site [chemical binding]; other site
447217012371	NEF interaction site [polypeptide binding]; other site
447217012372	SBD interface [polypeptide binding]; other site
447217012373	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
447217012374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217012375	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217012376	binding surface
447217012377	TPR motif; other site
447217012378	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
447217012379	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
447217012380	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217012381	ATP binding site [chemical binding]; other site
447217012382	putative Mg++ binding site [ion binding]; other site
447217012383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217012384	nucleotide binding region [chemical binding]; other site
447217012385	ATP-binding site [chemical binding]; other site
447217012386	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
447217012387	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
447217012388	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
447217012389	SurA N-terminal domain; Region: SurA_N; pfam09312
447217012390	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
447217012391	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
447217012392	GTP-binding protein YchF; Reviewed; Region: PRK09601
447217012393	YchF GTPase; Region: YchF; cd01900
447217012394	G1 box; other site
447217012395	GTP/Mg2+ binding site [chemical binding]; other site
447217012396	Switch I region; other site
447217012397	G2 box; other site
447217012398	Switch II region; other site
447217012399	G3 box; other site
447217012400	G4 box; other site
447217012401	G5 box; other site
447217012402	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
447217012403	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
447217012404	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
447217012405	ATP synthase subunit C; Region: ATP-synt_C; cl00466
447217012406	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
447217012407	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
447217012408	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217012409	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217012410	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217012411	catalytic residue [active]
447217012412	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
447217012413	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217012414	inhibitor-cofactor binding pocket; inhibition site
447217012415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217012416	catalytic residue [active]
447217012417	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217012418	DNA gyrase subunit A; Validated; Region: PRK05560
447217012419	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
447217012420	CAP-like domain; other site
447217012421	active site
447217012422	primary dimer interface [polypeptide binding]; other site
447217012423	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217012424	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217012425	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217012426	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217012427	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217012428	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
447217012429	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
447217012430	gamma subunit interface [polypeptide binding]; other site
447217012431	epsilon subunit interface [polypeptide binding]; other site
447217012432	LBP interface [polypeptide binding]; other site
447217012433	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
447217012434	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
447217012435	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
447217012436	alpha subunit interaction interface [polypeptide binding]; other site
447217012437	Walker A motif; other site
447217012438	ATP binding site [chemical binding]; other site
447217012439	Walker B motif; other site
447217012440	inhibitor binding site; inhibition site
447217012441	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217012442	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
447217012443	core domain interface [polypeptide binding]; other site
447217012444	delta subunit interface [polypeptide binding]; other site
447217012445	epsilon subunit interface [polypeptide binding]; other site
447217012446	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
447217012447	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
447217012448	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
447217012449	beta subunit interaction interface [polypeptide binding]; other site
447217012450	Walker A motif; other site
447217012451	ATP binding site [chemical binding]; other site
447217012452	Walker B motif; other site
447217012453	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217012454	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
447217012455	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
447217012456	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
447217012457	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
447217012458	putative dimer interface [polypeptide binding]; other site
447217012459	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217012460	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
447217012461	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
447217012462	ParB-like nuclease domain; Region: ParB; smart00470
447217012463	KorB domain; Region: KorB; pfam08535
447217012464	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217012465	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
447217012466	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217012467	Magnesium ion binding site [ion binding]; other site
447217012468	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
447217012469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217012470	S-adenosylmethionine binding site [chemical binding]; other site
447217012471	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
447217012472	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
447217012473	RxxxH motif; other site
447217012474	membrane protein insertase; Provisional; Region: PRK01318
447217012475	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
447217012476	Haemolytic domain; Region: Haemolytic; pfam01809
447217012477	Ribonuclease P; Region: Ribonuclease_P; pfam00825
447217012478	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399