-- dump date 20140618_203830 -- class Genbank::misc_feature -- table misc_feature_note -- id note 455488000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 455488000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 455488000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000004 Walker A motif; other site 455488000005 ATP binding site [chemical binding]; other site 455488000006 Walker B motif; other site 455488000007 arginine finger; other site 455488000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 455488000009 DnaA box-binding interface [nucleotide binding]; other site 455488000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 455488000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 455488000012 putative DNA binding surface [nucleotide binding]; other site 455488000013 dimer interface [polypeptide binding]; other site 455488000014 beta-clamp/clamp loader binding surface; other site 455488000015 beta-clamp/translesion DNA polymerase binding surface; other site 455488000016 recombination protein F; Reviewed; Region: recF; PRK00064 455488000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488000018 Walker A/P-loop; other site 455488000019 ATP binding site [chemical binding]; other site 455488000020 Q-loop/lid; other site 455488000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488000022 ABC transporter signature motif; other site 455488000023 Walker B; other site 455488000024 D-loop; other site 455488000025 H-loop/switch region; other site 455488000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 455488000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000028 ATP binding site [chemical binding]; other site 455488000029 Mg2+ binding site [ion binding]; other site 455488000030 G-X-G motif; other site 455488000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 455488000032 anchoring element; other site 455488000033 dimer interface [polypeptide binding]; other site 455488000034 ATP binding site [chemical binding]; other site 455488000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 455488000036 active site 455488000037 putative metal-binding site [ion binding]; other site 455488000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 455488000039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 455488000040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 455488000041 dimer interface [polypeptide binding]; other site 455488000042 active site 455488000043 CoA binding pocket [chemical binding]; other site 455488000044 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 455488000045 active site 455488000046 Zn binding site [ion binding]; other site 455488000047 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488000048 Cysteine-rich domain; Region: CCG; pfam02754 455488000049 Cysteine-rich domain; Region: CCG; pfam02754 455488000050 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 455488000051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488000052 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 455488000053 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488000054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 455488000055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488000056 active site 455488000057 HIGH motif; other site 455488000058 nucleotide binding site [chemical binding]; other site 455488000059 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 455488000060 active site 455488000061 KMSKS motif; other site 455488000062 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 455488000063 tRNA binding surface [nucleotide binding]; other site 455488000064 anticodon binding site; other site 455488000065 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 455488000066 lipoprotein signal peptidase; Provisional; Region: PRK14773 455488000067 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 455488000068 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 455488000069 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 455488000070 active site 455488000071 catalytic residues [active] 455488000072 DNA binding site [nucleotide binding] 455488000073 Int/Topo IB signature motif; other site 455488000074 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 455488000075 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 455488000076 catalytic residues [active] 455488000077 catalytic nucleophile [active] 455488000078 Presynaptic Site I dimer interface [polypeptide binding]; other site 455488000079 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 455488000080 Synaptic Flat tetramer interface [polypeptide binding]; other site 455488000081 Synaptic Site I dimer interface [polypeptide binding]; other site 455488000082 DNA binding site [nucleotide binding] 455488000083 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 455488000084 Phage associated DNA primase [General function prediction only]; Region: COG3378 455488000085 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 455488000086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 455488000087 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 455488000088 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 455488000089 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 455488000090 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 455488000091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 455488000092 TIGR04255 family protein; Region: sporadTIGR04255 455488000093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488000094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488000095 dimer interface [polypeptide binding]; other site 455488000096 phosphorylation site [posttranslational modification] 455488000097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000098 ATP binding site [chemical binding]; other site 455488000099 Mg2+ binding site [ion binding]; other site 455488000100 G-X-G motif; other site 455488000101 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488000102 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 455488000103 active site 455488000104 metal binding site [ion binding]; metal-binding site 455488000105 prolyl-tRNA synthetase; Provisional; Region: PRK08661 455488000106 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 455488000107 dimer interface [polypeptide binding]; other site 455488000108 motif 1; other site 455488000109 active site 455488000110 motif 2; other site 455488000111 motif 3; other site 455488000112 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 455488000113 anticodon binding site; other site 455488000114 zinc-binding site [ion binding]; other site 455488000115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488000116 NAD(P) binding site [chemical binding]; other site 455488000117 active site 455488000118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488000119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488000120 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 455488000121 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 455488000122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488000123 dimerization interface [polypeptide binding]; other site 455488000124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488000125 dimer interface [polypeptide binding]; other site 455488000126 putative CheW interface [polypeptide binding]; other site 455488000127 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 455488000128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488000129 NAD(P) binding site [chemical binding]; other site 455488000130 active site 455488000131 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 455488000132 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 455488000133 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 455488000134 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 455488000135 Na binding site [ion binding]; other site 455488000136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488000137 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 455488000138 acyl-activating enzyme (AAE) consensus motif; other site 455488000139 AMP binding site [chemical binding]; other site 455488000140 active site 455488000141 CoA binding site [chemical binding]; other site 455488000142 ACT domain-containing protein [General function prediction only]; Region: COG4747 455488000143 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 455488000144 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 455488000145 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 455488000146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488000147 acyl-activating enzyme (AAE) consensus motif; other site 455488000148 AMP binding site [chemical binding]; other site 455488000149 active site 455488000150 CoA binding site [chemical binding]; other site 455488000151 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 455488000152 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 455488000153 PYR/PP interface [polypeptide binding]; other site 455488000154 TPP binding site [chemical binding]; other site 455488000155 dimer interface [polypeptide binding]; other site 455488000156 substrate binding site [chemical binding]; other site 455488000157 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 455488000158 TPP-binding site; other site 455488000159 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 455488000160 butyrate kinase; Provisional; Region: PRK03011 455488000161 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 455488000162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 455488000163 DNA-binding site [nucleotide binding]; DNA binding site 455488000164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488000165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488000166 homodimer interface [polypeptide binding]; other site 455488000167 catalytic residue [active] 455488000168 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 455488000169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488000170 Coenzyme A binding pocket [chemical binding]; other site 455488000171 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 455488000172 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 455488000173 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 455488000174 Ligand binding site [chemical binding]; other site 455488000175 Electron transfer flavoprotein domain; Region: ETF; pfam01012 455488000176 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 455488000177 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 455488000178 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 455488000179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488000180 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 455488000181 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 455488000182 EamA-like transporter family; Region: EamA; pfam00892 455488000183 EamA-like transporter family; Region: EamA; pfam00892 455488000184 MltA specific insert domain; Region: MltA; smart00925 455488000185 3D domain; Region: 3D; pfam06725 455488000186 uracil transporter; Provisional; Region: PRK10720 455488000187 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 455488000188 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 455488000189 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488000190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488000191 RNA binding surface [nucleotide binding]; other site 455488000192 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488000193 active site 455488000194 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 455488000195 Transglycosylase; Region: Transgly; pfam00912 455488000196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 455488000197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488000198 dimerization interface [polypeptide binding]; other site 455488000199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488000200 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488000201 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488000202 dimer interface [polypeptide binding]; other site 455488000203 putative CheW interface [polypeptide binding]; other site 455488000204 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488000205 dimer interface [polypeptide binding]; other site 455488000206 putative CheW interface [polypeptide binding]; other site 455488000207 EVE domain; Region: EVE; pfam01878 455488000208 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 455488000209 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 455488000210 putative acyltransferase; Provisional; Region: PRK05790 455488000211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 455488000212 dimer interface [polypeptide binding]; other site 455488000213 active site 455488000214 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 455488000215 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 455488000216 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 455488000217 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 455488000218 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 455488000219 active site 455488000220 oxyanion hole [active] 455488000221 catalytic triad [active] 455488000222 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 455488000223 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 455488000224 inhibitor-cofactor binding pocket; inhibition site 455488000225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488000226 catalytic residue [active] 455488000227 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 455488000228 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 455488000229 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 455488000230 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488000231 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488000232 protein binding site [polypeptide binding]; other site 455488000233 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 455488000234 thiamine phosphate binding site [chemical binding]; other site 455488000235 active site 455488000236 pyrophosphate binding site [ion binding]; other site 455488000237 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 455488000238 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 455488000239 catalytic triad [active] 455488000240 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 455488000241 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 455488000242 replicative DNA helicase; Region: DnaB; TIGR00665 455488000243 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 455488000244 Walker A motif; other site 455488000245 ATP binding site [chemical binding]; other site 455488000246 Walker B motif; other site 455488000247 DNA binding loops [nucleotide binding] 455488000248 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 455488000249 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 455488000250 LrgB-like family; Region: LrgB; cl00596 455488000251 LrgA family; Region: LrgA; pfam03788 455488000252 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 455488000253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488000254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488000255 dimerization interface [polypeptide binding]; other site 455488000256 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 455488000257 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 455488000258 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 455488000259 substrate binding pocket [chemical binding]; other site 455488000260 dimer interface [polypeptide binding]; other site 455488000261 inhibitor binding site; inhibition site 455488000262 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 455488000263 B12 binding site [chemical binding]; other site 455488000264 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 455488000265 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 455488000266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488000267 FeS/SAM binding site; other site 455488000268 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 455488000269 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 455488000270 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 455488000271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488000272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488000273 dimer interface [polypeptide binding]; other site 455488000274 phosphorylation site [posttranslational modification] 455488000275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000276 ATP binding site [chemical binding]; other site 455488000277 Mg2+ binding site [ion binding]; other site 455488000278 G-X-G motif; other site 455488000279 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 455488000280 Hemerythrin; Region: Hemerythrin; cd12107 455488000281 Fe binding site [ion binding]; other site 455488000282 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 455488000283 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 455488000284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488000285 FeS/SAM binding site; other site 455488000286 TRAM domain; Region: TRAM; cl01282 455488000287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 455488000288 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 455488000289 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 455488000290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 455488000291 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 455488000292 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 455488000293 Part of AAA domain; Region: AAA_19; pfam13245 455488000294 Family description; Region: UvrD_C_2; pfam13538 455488000295 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 455488000296 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 455488000297 active site 455488000298 purine riboside binding site [chemical binding]; other site 455488000299 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 455488000300 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 455488000301 DNA binding site [nucleotide binding] 455488000302 active site 455488000303 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 455488000304 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 455488000305 ligand binding site; other site 455488000306 oligomer interface; other site 455488000307 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 455488000308 dimer interface [polypeptide binding]; other site 455488000309 N-terminal domain interface [polypeptide binding]; other site 455488000310 sulfate 1 binding site; other site 455488000311 Response regulator receiver domain; Region: Response_reg; pfam00072 455488000312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000313 active site 455488000314 phosphorylation site [posttranslational modification] 455488000315 intermolecular recognition site; other site 455488000316 dimerization interface [polypeptide binding]; other site 455488000317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488000318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488000319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488000320 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488000321 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488000322 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488000323 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 455488000324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 455488000325 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488000326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000327 active site 455488000328 phosphorylation site [posttranslational modification] 455488000329 intermolecular recognition site; other site 455488000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000331 Walker A motif; other site 455488000332 ATP binding site [chemical binding]; other site 455488000333 Walker B motif; other site 455488000334 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488000335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488000336 dimer interface [polypeptide binding]; other site 455488000337 phosphorylation site [posttranslational modification] 455488000338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000339 ATP binding site [chemical binding]; other site 455488000340 Mg2+ binding site [ion binding]; other site 455488000341 G-X-G motif; other site 455488000342 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488000343 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488000344 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 455488000345 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 455488000346 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 455488000347 active site 455488000348 Zn binding site [ion binding]; other site 455488000349 rod shape-determining protein MreB; Provisional; Region: PRK13927 455488000350 MreB and similar proteins; Region: MreB_like; cd10225 455488000351 nucleotide binding site [chemical binding]; other site 455488000352 Mg binding site [ion binding]; other site 455488000353 putative protofilament interaction site [polypeptide binding]; other site 455488000354 RodZ interaction site [polypeptide binding]; other site 455488000355 rod shape-determining protein MreB; Provisional; Region: PRK13927 455488000356 MreB and similar proteins; Region: MreB_like; cd10225 455488000357 nucleotide binding site [chemical binding]; other site 455488000358 Mg binding site [ion binding]; other site 455488000359 putative protofilament interaction site [polypeptide binding]; other site 455488000360 RodZ interaction site [polypeptide binding]; other site 455488000361 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 455488000362 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488000363 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488000364 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 455488000365 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 455488000366 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488000367 active site 455488000368 ATP binding site [chemical binding]; other site 455488000369 substrate binding site [chemical binding]; other site 455488000370 activation loop (A-loop); other site 455488000371 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 455488000372 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 455488000373 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 455488000374 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 455488000375 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 455488000376 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 455488000377 putative active site [active] 455488000378 catalytic residue [active] 455488000379 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 455488000380 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 455488000381 5S rRNA interface [nucleotide binding]; other site 455488000382 CTC domain interface [polypeptide binding]; other site 455488000383 L16 interface [polypeptide binding]; other site 455488000384 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 455488000385 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 455488000386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488000387 active site 455488000388 regulatory protein SpoVG; Reviewed; Region: PRK13259 455488000389 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 455488000390 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 455488000391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 455488000392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488000393 active site 455488000394 PilZ domain; Region: PilZ; pfam07238 455488000395 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 455488000396 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 455488000397 putative active site [active] 455488000398 catalytic site [active] 455488000399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488000400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488000401 phosphopeptide binding site; other site 455488000402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488000403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488000404 metal binding site [ion binding]; metal-binding site 455488000405 active site 455488000406 I-site; other site 455488000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488000408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488000409 putative substrate translocation pore; other site 455488000410 ADP-glucose phosphorylase; Region: PLN02643 455488000411 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 455488000412 nucleotide binding site/active site [active] 455488000413 HIT family signature motif; other site 455488000414 catalytic residue [active] 455488000415 glycogen synthase; Provisional; Region: glgA; PRK00654 455488000416 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 455488000417 ADP-binding pocket [chemical binding]; other site 455488000418 homodimer interface [polypeptide binding]; other site 455488000419 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 455488000420 SIR2-like domain; Region: SIR2_2; pfam13289 455488000421 hydroxyglutarate oxidase; Provisional; Region: PRK11728 455488000422 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 455488000423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488000424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488000425 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 455488000426 active site 455488000427 DNA polymerase IV; Validated; Region: PRK02406 455488000428 DNA binding site [nucleotide binding] 455488000429 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488000430 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488000431 active site 455488000432 metal binding site [ion binding]; metal-binding site 455488000433 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 455488000434 Response regulator receiver domain; Region: Response_reg; pfam00072 455488000435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000436 active site 455488000437 phosphorylation site [posttranslational modification] 455488000438 intermolecular recognition site; other site 455488000439 dimerization interface [polypeptide binding]; other site 455488000440 DHHA1 domain; Region: DHHA1; pfam02272 455488000441 HPr kinase/phosphorylase; Provisional; Region: PRK05428 455488000442 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 455488000443 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 455488000444 Hpr binding site; other site 455488000445 active site 455488000446 homohexamer subunit interaction site [polypeptide binding]; other site 455488000447 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 455488000448 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488000449 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 455488000450 active pocket/dimerization site; other site 455488000451 active site 455488000452 phosphorylation site [posttranslational modification] 455488000453 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 455488000454 active site 455488000455 phosphorylation site [posttranslational modification] 455488000456 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 455488000457 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 455488000458 dimerization domain swap beta strand [polypeptide binding]; other site 455488000459 regulatory protein interface [polypeptide binding]; other site 455488000460 active site 455488000461 regulatory phosphorylation site [posttranslational modification]; other site 455488000462 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 455488000463 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 455488000464 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 455488000465 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 455488000466 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 455488000467 S-adenosylmethionine synthetase; Validated; Region: PRK05250 455488000468 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 455488000469 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 455488000470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488000471 putative DNA binding site [nucleotide binding]; other site 455488000472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488000473 S-adenosylmethionine binding site [chemical binding]; other site 455488000474 Adenosylhomocysteinase; Provisional; Region: PTZ00075 455488000475 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 455488000476 homotetramer interface [polypeptide binding]; other site 455488000477 ligand binding site [chemical binding]; other site 455488000478 catalytic site [active] 455488000479 NAD binding site [chemical binding]; other site 455488000480 Bacitracin resistance protein BacA; Region: BacA; pfam02673 455488000481 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 455488000482 putative active site [active] 455488000483 putative CoA binding site [chemical binding]; other site 455488000484 nudix motif; other site 455488000485 metal binding site [ion binding]; metal-binding site 455488000486 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 455488000487 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 455488000488 Substrate binding site; other site 455488000489 Cupin domain; Region: Cupin_2; cl17218 455488000490 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 455488000491 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 455488000492 active site 455488000493 substrate binding site [chemical binding]; other site 455488000494 metal binding site [ion binding]; metal-binding site 455488000495 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 455488000496 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488000497 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488000498 Domain of unknown function (DUF814); Region: DUF814; pfam05670 455488000499 SprT-like family; Region: SprT-like; pfam10263 455488000500 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488000501 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488000502 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488000503 Family of unknown function (DUF490); Region: DUF490; pfam04357 455488000504 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 455488000505 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 455488000506 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 455488000507 hypothetical protein; Provisional; Region: PRK07338 455488000508 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 455488000509 metal binding site [ion binding]; metal-binding site 455488000510 dimer interface [polypeptide binding]; other site 455488000511 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 455488000512 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 455488000513 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 455488000514 nucleotide binding site [chemical binding]; other site 455488000515 N-acetyl-L-glutamate binding site [chemical binding]; other site 455488000516 Sulfatase; Region: Sulfatase; cl17466 455488000517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488000518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488000519 dimer interface [polypeptide binding]; other site 455488000520 phosphorylation site [posttranslational modification] 455488000521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000522 ATP binding site [chemical binding]; other site 455488000523 Mg2+ binding site [ion binding]; other site 455488000524 G-X-G motif; other site 455488000525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488000526 S-adenosylmethionine binding site [chemical binding]; other site 455488000527 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 455488000528 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 455488000529 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 455488000530 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 455488000531 putative active site [active] 455488000532 dimerization interface [polypeptide binding]; other site 455488000533 putative tRNAtyr binding site [nucleotide binding]; other site 455488000534 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 455488000535 nucleotide binding site/active site [active] 455488000536 HIT family signature motif; other site 455488000537 catalytic residue [active] 455488000538 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 455488000539 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 455488000540 homotrimer interaction site [polypeptide binding]; other site 455488000541 active site 455488000542 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 455488000543 prephenate dehydrogenase; Validated; Region: PRK08507 455488000544 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 455488000545 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 455488000546 hinge; other site 455488000547 active site 455488000548 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 455488000549 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 455488000550 NAD(P) binding site [chemical binding]; other site 455488000551 shikimate binding site; other site 455488000552 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 455488000553 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 455488000554 Tetramer interface [polypeptide binding]; other site 455488000555 active site 455488000556 FMN-binding site [chemical binding]; other site 455488000557 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 455488000558 shikimate kinase; Reviewed; Region: aroK; PRK00131 455488000559 active site 455488000560 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 455488000561 active site 455488000562 dimer interface [polypeptide binding]; other site 455488000563 metal binding site [ion binding]; metal-binding site 455488000564 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 455488000565 Dehydroquinase class II; Region: DHquinase_II; pfam01220 455488000566 active site 455488000567 trimer interface [polypeptide binding]; other site 455488000568 dimer interface [polypeptide binding]; other site 455488000569 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 455488000570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488000571 active site 455488000572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488000573 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 455488000574 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 455488000575 heme binding site [chemical binding]; other site 455488000576 ferroxidase pore; other site 455488000577 ferroxidase diiron center [ion binding]; other site 455488000578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 455488000579 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 455488000580 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488000581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488000582 RNA binding surface [nucleotide binding]; other site 455488000583 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488000584 active site 455488000585 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 455488000586 CoA binding domain; Region: CoA_binding; cl17356 455488000587 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 455488000588 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 455488000589 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 455488000590 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 455488000591 HflX GTPase family; Region: HflX; cd01878 455488000592 G1 box; other site 455488000593 GTP/Mg2+ binding site [chemical binding]; other site 455488000594 Switch I region; other site 455488000595 G2 box; other site 455488000596 G3 box; other site 455488000597 Switch II region; other site 455488000598 G4 box; other site 455488000599 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 455488000600 putative sialic acid transporter; Region: 2A0112; TIGR00891 455488000601 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 455488000602 active site 455488000603 catalytic site [active] 455488000604 substrate binding site [chemical binding]; other site 455488000605 LysE type translocator; Region: LysE; cl00565 455488000606 Peptidase family M48; Region: Peptidase_M48; cl12018 455488000607 gamma-glutamyl kinase; Provisional; Region: PRK05429 455488000608 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 455488000609 nucleotide binding site [chemical binding]; other site 455488000610 homotetrameric interface [polypeptide binding]; other site 455488000611 putative phosphate binding site [ion binding]; other site 455488000612 putative allosteric binding site; other site 455488000613 PUA domain; Region: PUA; cl00607 455488000614 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 455488000615 putative catalytic cysteine [active] 455488000616 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 455488000617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488000618 S-adenosylmethionine binding site [chemical binding]; other site 455488000619 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 455488000620 EamA-like transporter family; Region: EamA; pfam00892 455488000621 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488000622 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488000623 active site 455488000624 ATP binding site [chemical binding]; other site 455488000625 substrate binding site [chemical binding]; other site 455488000626 activation loop (A-loop); other site 455488000627 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 455488000628 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 455488000629 dimer interface [polypeptide binding]; other site 455488000630 PYR/PP interface [polypeptide binding]; other site 455488000631 TPP binding site [chemical binding]; other site 455488000632 substrate binding site [chemical binding]; other site 455488000633 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 455488000634 Domain of unknown function; Region: EKR; pfam10371 455488000635 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488000636 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 455488000637 TPP-binding site [chemical binding]; other site 455488000638 dimer interface [polypeptide binding]; other site 455488000639 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488000640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488000641 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 455488000642 putative NAD(P) binding site [chemical binding]; other site 455488000643 active site 455488000644 putative substrate binding site [chemical binding]; other site 455488000645 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 455488000646 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 455488000647 putative catalytic site [active] 455488000648 putative phosphate binding site [ion binding]; other site 455488000649 putative metal binding site [ion binding]; other site 455488000650 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488000651 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488000652 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 455488000653 DsrE/DsrF-like family; Region: DrsE; pfam02635 455488000654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488000655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488000656 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 455488000657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488000658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488000659 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 455488000660 Putative zinc-finger; Region: zf-HC2; pfam13490 455488000661 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 455488000662 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 455488000663 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 455488000664 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 455488000665 active site 455488000666 catalytic residues [active] 455488000667 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 455488000668 phosphoglyceromutase; Provisional; Region: PRK05434 455488000669 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 455488000670 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 455488000671 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 455488000672 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 455488000673 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 455488000674 TfoX N-terminal domain; Region: TfoX_N; pfam04993 455488000675 coproporphyrinogen III oxidase; Validated; Region: PRK05628 455488000676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488000677 FeS/SAM binding site; other site 455488000678 HemN C-terminal domain; Region: HemN_C; pfam06969 455488000679 OPT oligopeptide transporter protein; Region: OPT; cl14607 455488000680 putative oligopeptide transporter, OPT family; Region: TIGR00733 455488000681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000682 active site 455488000683 phosphorylation site [posttranslational modification] 455488000684 intermolecular recognition site; other site 455488000685 dimerization interface [polypeptide binding]; other site 455488000686 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 455488000687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488000688 S-adenosylmethionine binding site [chemical binding]; other site 455488000689 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 455488000690 RNA methyltransferase, RsmE family; Region: TIGR00046 455488000691 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488000692 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 455488000693 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 455488000694 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 455488000695 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488000696 DNA-binding site [nucleotide binding]; DNA binding site 455488000697 RNA-binding motif; other site 455488000698 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 455488000699 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 455488000700 FMN binding site [chemical binding]; other site 455488000701 substrate binding site [chemical binding]; other site 455488000702 putative catalytic residue [active] 455488000703 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488000704 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 455488000705 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488000706 putative acyl-acceptor binding pocket; other site 455488000707 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 455488000708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488000709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488000710 dimer interface [polypeptide binding]; other site 455488000711 phosphorylation site [posttranslational modification] 455488000712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000713 ATP binding site [chemical binding]; other site 455488000714 Mg2+ binding site [ion binding]; other site 455488000715 G-X-G motif; other site 455488000716 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 455488000717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488000718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488000719 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 455488000720 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 455488000721 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488000722 carboxyltransferase (CT) interaction site; other site 455488000723 biotinylation site [posttranslational modification]; other site 455488000724 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 455488000725 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488000726 HSP70 interaction site [polypeptide binding]; other site 455488000727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488000728 binding surface 455488000729 TPR motif; other site 455488000730 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 455488000731 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 455488000732 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488000733 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488000734 active site 455488000735 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 455488000736 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 455488000737 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 455488000738 Gram-negative bacterial tonB protein; Region: TonB; cl10048 455488000739 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488000740 elongation factor Ts; Reviewed; Region: tsf; PRK12332 455488000741 UBA/TS-N domain; Region: UBA; pfam00627 455488000742 Elongation factor TS; Region: EF_TS; pfam00889 455488000743 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 455488000744 rRNA interaction site [nucleotide binding]; other site 455488000745 S8 interaction site; other site 455488000746 putative laminin-1 binding site; other site 455488000747 Competence protein CoiA-like family; Region: CoiA; cl11541 455488000748 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 455488000749 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488000750 catalytic triad [active] 455488000751 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 455488000752 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 455488000753 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 455488000754 DNA binding site [nucleotide binding] 455488000755 catalytic residue [active] 455488000756 H2TH interface [polypeptide binding]; other site 455488000757 putative catalytic residues [active] 455488000758 turnover-facilitating residue; other site 455488000759 intercalation triad [nucleotide binding]; other site 455488000760 8OG recognition residue [nucleotide binding]; other site 455488000761 putative reading head residues; other site 455488000762 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 455488000763 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 455488000764 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 455488000765 RNA/DNA hybrid binding site [nucleotide binding]; other site 455488000766 active site 455488000767 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 455488000768 active site 455488000769 NTP binding site [chemical binding]; other site 455488000770 metal binding triad [ion binding]; metal-binding site 455488000771 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 455488000772 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 455488000773 putative nucleotide binding site [chemical binding]; other site 455488000774 uridine monophosphate binding site [chemical binding]; other site 455488000775 homohexameric interface [polypeptide binding]; other site 455488000776 ribosome recycling factor; Reviewed; Region: frr; PRK00083 455488000777 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 455488000778 hinge region; other site 455488000779 NAD synthetase; Provisional; Region: PRK13981 455488000780 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 455488000781 multimer interface [polypeptide binding]; other site 455488000782 active site 455488000783 catalytic triad [active] 455488000784 protein interface 1 [polypeptide binding]; other site 455488000785 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 455488000786 homodimer interface [polypeptide binding]; other site 455488000787 NAD binding pocket [chemical binding]; other site 455488000788 ATP binding pocket [chemical binding]; other site 455488000789 Mg binding site [ion binding]; other site 455488000790 active-site loop [active] 455488000791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488000792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488000793 metal binding site [ion binding]; metal-binding site 455488000794 active site 455488000795 I-site; other site 455488000796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488000797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488000798 DNA binding residues [nucleotide binding] 455488000799 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 455488000800 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 455488000801 TPP-binding site [chemical binding]; other site 455488000802 dimer interface [polypeptide binding]; other site 455488000803 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 455488000804 PYR/PP interface [polypeptide binding]; other site 455488000805 dimer interface [polypeptide binding]; other site 455488000806 TPP binding site [chemical binding]; other site 455488000807 Ycf46; Provisional; Region: ycf46; CHL00195 455488000808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000809 ATP binding site [chemical binding]; other site 455488000810 Walker A motif; other site 455488000811 Walker B motif; other site 455488000812 arginine finger; other site 455488000813 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 455488000814 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 455488000815 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 455488000816 active site 455488000817 catalytic site [active] 455488000818 4-alpha-glucanotransferase; Provisional; Region: PRK14508 455488000819 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 455488000820 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 455488000821 active site 455488000822 HIGH motif; other site 455488000823 nucleotide binding site [chemical binding]; other site 455488000824 active site 455488000825 KMSKS motif; other site 455488000826 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 455488000827 active site 455488000828 dinuclear metal binding site [ion binding]; other site 455488000829 dimerization interface [polypeptide binding]; other site 455488000830 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 455488000831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000832 ATP binding site [chemical binding]; other site 455488000833 Mg2+ binding site [ion binding]; other site 455488000834 G-X-G motif; other site 455488000835 Response regulator receiver domain; Region: Response_reg; pfam00072 455488000836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000837 active site 455488000838 phosphorylation site [posttranslational modification] 455488000839 intermolecular recognition site; other site 455488000840 dimerization interface [polypeptide binding]; other site 455488000841 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488000842 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488000843 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488000844 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488000845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488000846 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 455488000847 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 455488000848 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 455488000849 FAD binding pocket [chemical binding]; other site 455488000850 FAD binding motif [chemical binding]; other site 455488000851 phosphate binding motif [ion binding]; other site 455488000852 beta-alpha-beta structure motif; other site 455488000853 NAD binding pocket [chemical binding]; other site 455488000854 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 455488000855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488000856 dimerization interface [polypeptide binding]; other site 455488000857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488000858 dimer interface [polypeptide binding]; other site 455488000859 phosphorylation site [posttranslational modification] 455488000860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488000861 ATP binding site [chemical binding]; other site 455488000862 Mg2+ binding site [ion binding]; other site 455488000863 G-X-G motif; other site 455488000864 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488000865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488000866 active site 455488000867 phosphorylation site [posttranslational modification] 455488000868 intermolecular recognition site; other site 455488000869 dimerization interface [polypeptide binding]; other site 455488000870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000871 ATP binding site [chemical binding]; other site 455488000872 Walker B motif; other site 455488000873 arginine finger; other site 455488000874 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488000875 Protein of unknown function (DUF456); Region: DUF456; pfam04306 455488000876 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 455488000877 Ligand binding site; other site 455488000878 metal-binding site 455488000879 Uncharacterized conserved protein [Function unknown]; Region: COG3342 455488000880 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 455488000881 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 455488000882 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488000883 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 455488000884 active site 1 [active] 455488000885 dimer interface [polypeptide binding]; other site 455488000886 hexamer interface [polypeptide binding]; other site 455488000887 active site 2 [active] 455488000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488000889 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 455488000890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488000891 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 455488000892 dimerization interface [polypeptide binding]; other site 455488000893 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 455488000894 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 455488000895 dimer interface [polypeptide binding]; other site 455488000896 decamer (pentamer of dimers) interface [polypeptide binding]; other site 455488000897 catalytic triad [active] 455488000898 peroxidatic and resolving cysteines [active] 455488000899 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 455488000900 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 455488000901 AAA ATPase domain; Region: AAA_16; pfam13191 455488000902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488000903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488000904 DNA binding residues [nucleotide binding] 455488000905 dimerization interface [polypeptide binding]; other site 455488000906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488000907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488000908 DNA binding residues [nucleotide binding] 455488000909 dimerization interface [polypeptide binding]; other site 455488000910 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 455488000911 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 455488000912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488000913 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 455488000914 Bacterial Ig-like domain; Region: Big_5; pfam13205 455488000915 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 455488000916 Peptidase family M1; Region: Peptidase_M1; pfam01433 455488000917 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 455488000918 Zn binding site [ion binding]; other site 455488000919 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 455488000920 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 455488000921 methionine sulfoxide reductase B; Provisional; Region: PRK00222 455488000922 SelR domain; Region: SelR; pfam01641 455488000923 Activator of aromatic catabolism; Region: XylR_N; pfam06505 455488000924 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 455488000925 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488000926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000927 Walker B motif; other site 455488000928 arginine finger; other site 455488000929 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488000930 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 455488000931 eyelet of channel; other site 455488000932 trimer interface [polypeptide binding]; other site 455488000933 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 455488000934 reductive dehalogenase; Region: RDH; TIGR02486 455488000935 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 455488000936 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488000937 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 455488000938 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 455488000939 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 455488000940 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 455488000941 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 455488000942 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 455488000943 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 455488000944 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 455488000945 Activator of aromatic catabolism; Region: XylR_N; pfam06505 455488000946 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 455488000947 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 455488000948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000949 Walker A motif; other site 455488000950 ATP binding site [chemical binding]; other site 455488000951 Walker B motif; other site 455488000952 arginine finger; other site 455488000953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488000954 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 455488000955 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 455488000956 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 455488000957 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488000958 catalytic residues [active] 455488000959 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 455488000960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488000961 dimer interface [polypeptide binding]; other site 455488000962 putative CheW interface [polypeptide binding]; other site 455488000963 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 455488000964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488000965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488000966 dimerization interface [polypeptide binding]; other site 455488000967 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 455488000968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488000969 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 455488000970 catalytic site [active] 455488000971 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 455488000972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488000973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488000974 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 455488000975 putative dimerization interface [polypeptide binding]; other site 455488000976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488000977 DoxX-like family; Region: DoxX_2; pfam13564 455488000978 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 455488000979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488000980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488000981 DNA binding residues [nucleotide binding] 455488000982 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 455488000983 Divergent AAA domain; Region: AAA_4; pfam04326 455488000984 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 455488000985 Propionate catabolism activator; Region: PrpR_N; pfam06506 455488000986 PAS domain; Region: PAS; smart00091 455488000987 PAS domain; Region: PAS_10; pfam13596 455488000988 putative active site [active] 455488000989 heme pocket [chemical binding]; other site 455488000990 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 455488000991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488000992 Walker A motif; other site 455488000993 ATP binding site [chemical binding]; other site 455488000994 Walker B motif; other site 455488000995 arginine finger; other site 455488000996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488000997 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 455488000998 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 455488000999 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 455488001000 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 455488001001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488001002 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 455488001003 substrate binding site [chemical binding]; other site 455488001004 oxyanion hole (OAH) forming residues; other site 455488001005 trimer interface [polypeptide binding]; other site 455488001006 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 455488001007 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 455488001008 dimer interface [polypeptide binding]; other site 455488001009 active site 455488001010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488001011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488001012 active site 455488001013 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 455488001014 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 455488001015 Moco binding site; other site 455488001016 metal coordination site [ion binding]; other site 455488001017 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 455488001018 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 455488001019 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 455488001020 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 455488001021 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 455488001022 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 455488001023 hinge; other site 455488001024 active site 455488001025 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 455488001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488001027 peptide chain release factor 1; Validated; Region: prfA; PRK00591 455488001028 This domain is found in peptide chain release factors; Region: PCRF; smart00937 455488001029 RF-1 domain; Region: RF-1; pfam00472 455488001030 Predicted transcriptional regulators [Transcription]; Region: COG1510 455488001031 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 455488001032 UbiA prenyltransferase family; Region: UbiA; pfam01040 455488001033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488001034 active site 455488001035 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 455488001036 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 455488001037 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 455488001038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488001039 FeS/SAM binding site; other site 455488001040 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 455488001041 Flavoprotein; Region: Flavoprotein; pfam02441 455488001042 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 455488001043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488001044 S-adenosylmethionine binding site [chemical binding]; other site 455488001045 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 455488001046 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488001047 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488001048 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 455488001049 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 455488001050 substrate binding pocket [chemical binding]; other site 455488001051 chain length determination region; other site 455488001052 substrate-Mg2+ binding site; other site 455488001053 catalytic residues [active] 455488001054 aspartate-rich region 1; other site 455488001055 active site lid residues [active] 455488001056 aspartate-rich region 2; other site 455488001057 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 455488001058 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 455488001059 dimerization interface 3.5A [polypeptide binding]; other site 455488001060 active site 455488001061 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 455488001062 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 455488001063 Hemerythrin; Region: Hemerythrin; cd12107 455488001064 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 455488001065 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 455488001066 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 455488001067 Clp amino terminal domain; Region: Clp_N; pfam02861 455488001068 Clp amino terminal domain; Region: Clp_N; pfam02861 455488001069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001070 Walker A motif; other site 455488001071 ATP binding site [chemical binding]; other site 455488001072 Walker B motif; other site 455488001073 arginine finger; other site 455488001074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001075 Walker A motif; other site 455488001076 ATP binding site [chemical binding]; other site 455488001077 Walker B motif; other site 455488001078 arginine finger; other site 455488001079 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 455488001080 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 455488001081 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488001082 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488001083 protein binding site [polypeptide binding]; other site 455488001084 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 455488001085 protein binding site [polypeptide binding]; other site 455488001086 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 455488001087 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 455488001088 malonyl-CoA binding site [chemical binding]; other site 455488001089 dimer interface [polypeptide binding]; other site 455488001090 active site 455488001091 product binding site; other site 455488001092 acyl-CoA synthetase; Validated; Region: PRK09192 455488001093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488001094 acyl-activating enzyme (AAE) consensus motif; other site 455488001095 AMP binding site [chemical binding]; other site 455488001096 active site 455488001097 CoA binding site [chemical binding]; other site 455488001098 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 455488001099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 455488001100 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 455488001101 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 455488001102 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 455488001103 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 455488001104 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 455488001105 Zn binding site [ion binding]; other site 455488001106 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 455488001107 FAD binding pocket [chemical binding]; other site 455488001108 FAD binding motif [chemical binding]; other site 455488001109 phosphate binding motif [ion binding]; other site 455488001110 beta-alpha-beta structure motif; other site 455488001111 NAD(p) ribose binding residues [chemical binding]; other site 455488001112 NAD binding pocket [chemical binding]; other site 455488001113 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 455488001114 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 455488001115 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 455488001116 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 455488001117 ribonuclease Z; Region: RNase_Z; TIGR02651 455488001118 Pirin-related protein [General function prediction only]; Region: COG1741 455488001119 Pirin; Region: Pirin; pfam02678 455488001120 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 455488001121 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 455488001122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001123 Walker A/P-loop; other site 455488001124 ATP binding site [chemical binding]; other site 455488001125 Q-loop/lid; other site 455488001126 ABC transporter signature motif; other site 455488001127 Walker B; other site 455488001128 D-loop; other site 455488001129 H-loop/switch region; other site 455488001130 ParB-like nuclease domain; Region: ParB; smart00470 455488001131 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 455488001132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 455488001133 dimer interface [polypeptide binding]; other site 455488001134 active site 455488001135 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 455488001136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488001137 substrate binding site [chemical binding]; other site 455488001138 oxyanion hole (OAH) forming residues; other site 455488001139 trimer interface [polypeptide binding]; other site 455488001140 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 455488001141 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 455488001142 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 455488001143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488001144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001145 dimer interface [polypeptide binding]; other site 455488001146 phosphorylation site [posttranslational modification] 455488001147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001148 ATP binding site [chemical binding]; other site 455488001149 G-X-G motif; other site 455488001150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488001151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001152 active site 455488001153 phosphorylation site [posttranslational modification] 455488001154 intermolecular recognition site; other site 455488001155 dimerization interface [polypeptide binding]; other site 455488001156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488001157 DNA binding site [nucleotide binding] 455488001158 selenocysteine synthase; Provisional; Region: PRK04311 455488001159 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 455488001160 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488001161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488001162 catalytic residue [active] 455488001163 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 455488001164 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 455488001165 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488001166 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 455488001167 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488001168 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 455488001169 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488001170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001171 active site 455488001172 phosphorylation site [posttranslational modification] 455488001173 intermolecular recognition site; other site 455488001174 dimerization interface [polypeptide binding]; other site 455488001175 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488001176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001177 active site 455488001178 phosphorylation site [posttranslational modification] 455488001179 intermolecular recognition site; other site 455488001180 dimerization interface [polypeptide binding]; other site 455488001181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001182 Walker A motif; other site 455488001183 ATP binding site [chemical binding]; other site 455488001184 Walker B motif; other site 455488001185 arginine finger; other site 455488001186 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488001187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488001188 PAS domain; Region: PAS_9; pfam13426 455488001189 putative active site [active] 455488001190 heme pocket [chemical binding]; other site 455488001191 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488001192 GAF domain; Region: GAF; pfam01590 455488001193 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488001194 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488001195 GAF domain; Region: GAF_3; pfam13492 455488001196 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488001197 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488001198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488001199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001200 dimer interface [polypeptide binding]; other site 455488001201 phosphorylation site [posttranslational modification] 455488001202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001203 ATP binding site [chemical binding]; other site 455488001204 G-X-G motif; other site 455488001205 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 455488001206 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 455488001207 G1 box; other site 455488001208 putative GEF interaction site [polypeptide binding]; other site 455488001209 GTP/Mg2+ binding site [chemical binding]; other site 455488001210 Switch I region; other site 455488001211 G2 box; other site 455488001212 G3 box; other site 455488001213 Switch II region; other site 455488001214 G4 box; other site 455488001215 G5 box; other site 455488001216 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 455488001217 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 455488001218 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 455488001219 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 455488001220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488001221 active site 455488001222 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 455488001223 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 455488001224 dimerization interface [polypeptide binding]; other site 455488001225 domain crossover interface; other site 455488001226 redox-dependent activation switch; other site 455488001227 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 455488001228 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488001229 putative NAD(P) binding site [chemical binding]; other site 455488001230 active site 455488001231 putative substrate binding site [chemical binding]; other site 455488001232 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488001233 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 455488001234 putative acyl-acceptor binding pocket; other site 455488001235 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 455488001236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488001237 binding surface 455488001238 TPR motif; other site 455488001239 TPR repeat; Region: TPR_11; pfam13414 455488001240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488001241 TPR motif; other site 455488001242 binding surface 455488001243 TPR repeat; Region: TPR_11; pfam13414 455488001244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 455488001245 MarR family; Region: MarR_2; cl17246 455488001246 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 455488001247 GAF domain; Region: GAF; cl17456 455488001248 GAF domain; Region: GAF; pfam01590 455488001249 GAF domain; Region: GAF_2; pfam13185 455488001250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488001251 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488001252 phosphopeptide binding site; other site 455488001253 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488001254 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488001255 metal binding site [ion binding]; metal-binding site 455488001256 active site 455488001257 I-site; other site 455488001258 Protein of unknown function DUF72; Region: DUF72; pfam01904 455488001259 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 455488001260 putative catalytic site [active] 455488001261 putative metal binding site [ion binding]; other site 455488001262 putative phosphate binding site [ion binding]; other site 455488001263 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 455488001264 active site 455488001265 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 455488001266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001267 Walker A/P-loop; other site 455488001268 ATP binding site [chemical binding]; other site 455488001269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001270 Q-loop/lid; other site 455488001271 ABC transporter signature motif; other site 455488001272 Walker B; other site 455488001273 D-loop; other site 455488001274 H-loop/switch region; other site 455488001275 exonuclease subunit SbcD; Provisional; Region: PRK10966 455488001276 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488001277 active site 455488001278 metal binding site [ion binding]; metal-binding site 455488001279 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 455488001280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 455488001281 active site residue [active] 455488001282 Chromate transporter; Region: Chromate_transp; pfam02417 455488001283 Chromate transporter; Region: Chromate_transp; cl17781 455488001284 NosL; Region: NosL; cl01769 455488001285 FtsX-like permease family; Region: FtsX; pfam02687 455488001286 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488001287 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488001288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488001289 Walker A/P-loop; other site 455488001290 ATP binding site [chemical binding]; other site 455488001291 Q-loop/lid; other site 455488001292 ABC transporter signature motif; other site 455488001293 Walker B; other site 455488001294 D-loop; other site 455488001295 H-loop/switch region; other site 455488001296 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 455488001297 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 455488001298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488001299 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 455488001300 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 455488001301 active site 455488001302 homotetramer interface [polypeptide binding]; other site 455488001303 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 455488001304 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 455488001305 dinuclear metal binding motif [ion binding]; other site 455488001306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488001307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488001308 active site 455488001309 catalytic tetrad [active] 455488001310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 455488001311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488001312 S-adenosylmethionine binding site [chemical binding]; other site 455488001313 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 455488001314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001315 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 455488001316 Walker A/P-loop; other site 455488001317 ATP binding site [chemical binding]; other site 455488001318 Q-loop/lid; other site 455488001319 ABC transporter signature motif; other site 455488001320 Walker B; other site 455488001321 D-loop; other site 455488001322 H-loop/switch region; other site 455488001323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488001324 dimerization interface [polypeptide binding]; other site 455488001325 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 455488001326 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 455488001327 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 455488001328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 455488001329 substrate binding pocket [chemical binding]; other site 455488001330 membrane-bound complex binding site; other site 455488001331 hinge residues; other site 455488001332 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488001333 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 455488001334 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 455488001335 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 455488001336 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488001337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488001338 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 455488001339 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 455488001340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488001341 carboxyltransferase (CT) interaction site; other site 455488001342 biotinylation site [posttranslational modification]; other site 455488001343 RNA polymerase sigma factor; Provisional; Region: PRK11922 455488001344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488001345 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 455488001346 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 455488001347 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 455488001348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 455488001349 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 455488001350 Soluble P-type ATPase [General function prediction only]; Region: COG4087 455488001351 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 455488001352 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 455488001353 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 455488001354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488001355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488001356 homodimer interface [polypeptide binding]; other site 455488001357 catalytic residue [active] 455488001358 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488001359 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 455488001360 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 455488001361 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 455488001362 dimerization interface [polypeptide binding]; other site 455488001363 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 455488001364 ATP binding site [chemical binding]; other site 455488001365 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 455488001366 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 455488001367 HupF/HypC family; Region: HupF_HypC; pfam01455 455488001368 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 455488001369 Acylphosphatase; Region: Acylphosphatase; pfam00708 455488001370 HypF finger; Region: zf-HYPF; pfam07503 455488001371 HypF finger; Region: zf-HYPF; pfam07503 455488001372 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 455488001373 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 455488001374 nickel binding site [ion binding]; other site 455488001375 hydrogenase 2 large subunit; Provisional; Region: PRK10467 455488001376 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 455488001377 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 455488001378 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 455488001379 hydrogenase 2 small subunit; Provisional; Region: PRK10468 455488001380 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 455488001381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 455488001382 MarR family; Region: MarR_2; pfam12802 455488001383 Nudix hydrolase homolog; Region: PLN02791 455488001384 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 455488001385 N-terminal plug; other site 455488001386 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 455488001387 ligand-binding site [chemical binding]; other site 455488001388 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 455488001389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488001390 TPR repeat; Region: TPR_11; pfam13414 455488001391 TPR motif; other site 455488001392 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 455488001393 MgtC family; Region: MgtC; pfam02308 455488001394 Predicted membrane protein [Function unknown]; Region: COG2119 455488001395 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 455488001396 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 455488001397 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 455488001398 YwiC-like protein; Region: YwiC; pfam14256 455488001399 Hemerythrin; Region: Hemerythrin; cd12107 455488001400 Fe binding site [ion binding]; other site 455488001401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 455488001402 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 455488001403 Walker A/P-loop; other site 455488001404 ATP binding site [chemical binding]; other site 455488001405 Q-loop/lid; other site 455488001406 ABC transporter signature motif; other site 455488001407 Walker B; other site 455488001408 D-loop; other site 455488001409 H-loop/switch region; other site 455488001410 cobalt transport protein CbiM; Provisional; Region: PRK07331 455488001411 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 455488001412 nickel responsive regulator; Provisional; Region: PRK04460 455488001413 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 455488001414 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 455488001415 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 455488001416 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 455488001417 substrate binding site [chemical binding]; other site 455488001418 ATP binding site [chemical binding]; other site 455488001419 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 455488001420 TAP-like protein; Region: Abhydrolase_4; pfam08386 455488001421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488001422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001423 dimer interface [polypeptide binding]; other site 455488001424 phosphorylation site [posttranslational modification] 455488001425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001426 ATP binding site [chemical binding]; other site 455488001427 G-X-G motif; other site 455488001428 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488001429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001430 active site 455488001431 phosphorylation site [posttranslational modification] 455488001432 intermolecular recognition site; other site 455488001433 dimerization interface [polypeptide binding]; other site 455488001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001435 Walker A motif; other site 455488001436 ATP binding site [chemical binding]; other site 455488001437 Walker B motif; other site 455488001438 arginine finger; other site 455488001439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488001440 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 455488001441 putative active site [active] 455488001442 redox center [active] 455488001443 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488001444 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488001445 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488001446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488001447 putative active site [active] 455488001448 heme pocket [chemical binding]; other site 455488001449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001450 dimer interface [polypeptide binding]; other site 455488001451 phosphorylation site [posttranslational modification] 455488001452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001453 ATP binding site [chemical binding]; other site 455488001454 Mg2+ binding site [ion binding]; other site 455488001455 G-X-G motif; other site 455488001456 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 455488001457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488001458 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 455488001459 dimerization interface [polypeptide binding]; other site 455488001460 active site 455488001461 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 455488001462 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 455488001463 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 455488001464 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 455488001465 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 455488001466 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 455488001467 Protein export membrane protein; Region: SecD_SecF; cl14618 455488001468 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488001469 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488001470 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488001471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488001472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488001473 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 455488001474 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 455488001475 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 455488001476 Ca binding site [ion binding]; other site 455488001477 active site 455488001478 catalytic site [active] 455488001479 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 455488001480 active site 455488001481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 455488001482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 455488001483 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 455488001484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488001485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488001486 dimerization interface [polypeptide binding]; other site 455488001487 aspartate racemase; Region: asp_race; TIGR00035 455488001488 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 455488001489 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 455488001490 putative dimer interface [polypeptide binding]; other site 455488001491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488001492 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 455488001493 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 455488001494 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 455488001495 aspartate aminotransferase; Provisional; Region: PRK06836 455488001496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488001497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488001498 homodimer interface [polypeptide binding]; other site 455488001499 catalytic residue [active] 455488001500 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 455488001501 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 455488001502 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 455488001503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488001504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001505 dimer interface [polypeptide binding]; other site 455488001506 phosphorylation site [posttranslational modification] 455488001507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001508 ATP binding site [chemical binding]; other site 455488001509 Mg2+ binding site [ion binding]; other site 455488001510 G-X-G motif; other site 455488001511 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 455488001512 AAA domain; Region: AAA_21; pfam13304 455488001513 Walker A/P-loop; other site 455488001514 ATP binding site [chemical binding]; other site 455488001515 ABC transporter; Region: ABC_tran; pfam00005 455488001516 Q-loop/lid; other site 455488001517 ABC transporter signature motif; other site 455488001518 Walker B; other site 455488001519 D-loop; other site 455488001520 H-loop/switch region; other site 455488001521 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 455488001522 putative hydrolase; Provisional; Region: PRK11460 455488001523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488001524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488001525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 455488001526 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 455488001527 DsrE/DsrF-like family; Region: DrsE; pfam02635 455488001528 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 455488001529 Helix-turn-helix domain; Region: HTH_18; pfam12833 455488001530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488001531 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488001532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 455488001533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488001534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488001535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488001536 dimerization interface [polypeptide binding]; other site 455488001537 short chain dehydrogenase; Provisional; Region: PRK08303 455488001538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488001539 NAD(P) binding site [chemical binding]; other site 455488001540 active site 455488001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488001542 putative substrate translocation pore; other site 455488001543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488001544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488001545 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 455488001546 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 455488001547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488001548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488001549 DNA binding residues [nucleotide binding] 455488001550 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 455488001551 Predicted ATPase [General function prediction only]; Region: COG4637 455488001552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001553 Walker A/P-loop; other site 455488001554 ATP binding site [chemical binding]; other site 455488001555 Fic family protein [Function unknown]; Region: COG3177 455488001556 Fic/DOC family; Region: Fic; pfam02661 455488001557 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 455488001558 DEAD-like helicases superfamily; Region: DEXDc; smart00487 455488001559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488001560 ATP binding site [chemical binding]; other site 455488001561 putative Mg++ binding site [ion binding]; other site 455488001562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 455488001563 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 455488001564 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 455488001565 metal binding site [ion binding]; metal-binding site 455488001566 putative dimer interface [polypeptide binding]; other site 455488001567 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 455488001568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488001569 active site 455488001570 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 455488001571 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 455488001572 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 455488001573 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001575 active site 455488001576 phosphorylation site [posttranslational modification] 455488001577 intermolecular recognition site; other site 455488001578 dimerization interface [polypeptide binding]; other site 455488001579 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488001580 GAF domain; Region: GAF_3; pfam13492 455488001581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488001582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488001583 metal binding site [ion binding]; metal-binding site 455488001584 active site 455488001585 I-site; other site 455488001586 Tellurium resistance protein; Region: Tellurium_res; pfam10138 455488001587 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001589 active site 455488001590 phosphorylation site [posttranslational modification] 455488001591 intermolecular recognition site; other site 455488001592 dimerization interface [polypeptide binding]; other site 455488001593 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488001594 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 455488001595 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488001596 KMSKS motif; other site 455488001597 Hemerythrin; Region: Hemerythrin; cd12107 455488001598 Fe binding site [ion binding]; other site 455488001599 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488001600 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488001601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488001602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488001603 dimerization interface [polypeptide binding]; other site 455488001604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001605 ATP binding site [chemical binding]; other site 455488001606 Mg2+ binding site [ion binding]; other site 455488001607 G-X-G motif; other site 455488001608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 455488001609 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 455488001610 WYL domain; Region: WYL; pfam13280 455488001611 WYL domain; Region: WYL; pfam13280 455488001612 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001614 active site 455488001615 phosphorylation site [posttranslational modification] 455488001616 intermolecular recognition site; other site 455488001617 dimerization interface [polypeptide binding]; other site 455488001618 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 455488001619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 455488001620 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 455488001621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488001622 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 455488001623 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 455488001624 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 455488001625 heterotetramer interface [polypeptide binding]; other site 455488001626 active site pocket [active] 455488001627 cleavage site 455488001628 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 455488001629 homohexameric interface [polypeptide binding]; other site 455488001630 feedback inhibition sensing region; other site 455488001631 nucleotide binding site [chemical binding]; other site 455488001632 N-acetyl-L-glutamate binding site [chemical binding]; other site 455488001633 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 455488001634 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 455488001635 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 455488001636 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 455488001637 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488001638 DsbD alpha interface [polypeptide binding]; other site 455488001639 catalytic residues [active] 455488001640 cysteine desulfurase; Provisional; Region: PRK14012 455488001641 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 455488001642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488001643 catalytic residue [active] 455488001644 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 455488001645 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 455488001646 trimerization site [polypeptide binding]; other site 455488001647 active site 455488001648 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 455488001649 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488001650 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 455488001651 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 455488001652 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 455488001653 nucleotide binding site [chemical binding]; other site 455488001654 putative NEF/HSP70 interaction site [polypeptide binding]; other site 455488001655 SBD interface [polypeptide binding]; other site 455488001656 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 455488001657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 455488001658 catalytic loop [active] 455488001659 iron binding site [ion binding]; other site 455488001660 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 455488001661 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 455488001662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001663 active site 455488001664 phosphorylation site [posttranslational modification] 455488001665 intermolecular recognition site; other site 455488001666 dimerization interface [polypeptide binding]; other site 455488001667 CheB methylesterase; Region: CheB_methylest; pfam01339 455488001668 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 455488001669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488001670 S-adenosylmethionine binding site [chemical binding]; other site 455488001671 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 455488001672 putative CheA interaction surface; other site 455488001673 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488001674 putative binding surface; other site 455488001675 active site 455488001676 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 455488001677 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 455488001678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001679 ATP binding site [chemical binding]; other site 455488001680 Mg2+ binding site [ion binding]; other site 455488001681 G-X-G motif; other site 455488001682 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 455488001683 CheD chemotactic sensory transduction; Region: CheD; cl00810 455488001684 GAF domain; Region: GAF_3; pfam13492 455488001685 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001687 active site 455488001688 phosphorylation site [posttranslational modification] 455488001689 intermolecular recognition site; other site 455488001690 dimerization interface [polypeptide binding]; other site 455488001691 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488001692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001693 active site 455488001694 phosphorylation site [posttranslational modification] 455488001695 intermolecular recognition site; other site 455488001696 CheW-like domain; Region: CheW; pfam01584 455488001697 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488001698 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488001699 dimer interface [polypeptide binding]; other site 455488001700 putative CheW interface [polypeptide binding]; other site 455488001701 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488001702 putative binding surface; other site 455488001703 active site 455488001704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001705 ATP binding site [chemical binding]; other site 455488001706 Mg2+ binding site [ion binding]; other site 455488001707 G-X-G motif; other site 455488001708 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 455488001709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001710 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001711 active site 455488001712 phosphorylation site [posttranslational modification] 455488001713 intermolecular recognition site; other site 455488001714 dimerization interface [polypeptide binding]; other site 455488001715 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 455488001716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001717 active site 455488001718 phosphorylation site [posttranslational modification] 455488001719 intermolecular recognition site; other site 455488001720 dimerization interface [polypeptide binding]; other site 455488001721 CheB methylesterase; Region: CheB_methylest; pfam01339 455488001722 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488001723 Response regulator receiver domain; Region: Response_reg; pfam00072 455488001724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001725 active site 455488001726 phosphorylation site [posttranslational modification] 455488001727 intermolecular recognition site; other site 455488001728 dimerization interface [polypeptide binding]; other site 455488001729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488001730 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 455488001731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488001732 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 455488001733 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 455488001734 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488001735 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 455488001736 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 455488001737 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 455488001738 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 455488001739 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 455488001740 purine nucleoside phosphorylase; Provisional; Region: PRK08202 455488001741 PilZ domain; Region: PilZ; pfam07238 455488001742 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 455488001743 active site 455488001744 catalytic motif [active] 455488001745 Zn binding site [ion binding]; other site 455488001746 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 455488001747 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 455488001748 active site 455488001749 Riboflavin kinase; Region: Flavokinase; pfam01687 455488001750 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 455488001751 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488001752 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 455488001753 Walker A motif; other site 455488001754 ATP binding site [chemical binding]; other site 455488001755 Walker B motif; other site 455488001756 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 455488001757 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 455488001758 Walker A motif; other site 455488001759 ATP binding site [chemical binding]; other site 455488001760 Walker B motif; other site 455488001761 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 455488001762 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488001763 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488001764 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 455488001765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488001766 putative active site [active] 455488001767 heme pocket [chemical binding]; other site 455488001768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001769 dimer interface [polypeptide binding]; other site 455488001770 phosphorylation site [posttranslational modification] 455488001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001772 ATP binding site [chemical binding]; other site 455488001773 Mg2+ binding site [ion binding]; other site 455488001774 G-X-G motif; other site 455488001775 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488001776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001777 active site 455488001778 phosphorylation site [posttranslational modification] 455488001779 intermolecular recognition site; other site 455488001780 dimerization interface [polypeptide binding]; other site 455488001781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001782 Walker A motif; other site 455488001783 ATP binding site [chemical binding]; other site 455488001784 Walker B motif; other site 455488001785 arginine finger; other site 455488001786 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 455488001787 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 455488001788 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 455488001789 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 455488001790 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488001791 Walker A/P-loop; other site 455488001792 ATP binding site [chemical binding]; other site 455488001793 Q-loop/lid; other site 455488001794 ABC transporter signature motif; other site 455488001795 Walker B; other site 455488001796 D-loop; other site 455488001797 H-loop/switch region; other site 455488001798 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 455488001799 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 455488001800 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 455488001801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488001802 dimer interface [polypeptide binding]; other site 455488001803 phosphorylation site [posttranslational modification] 455488001804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488001805 ATP binding site [chemical binding]; other site 455488001806 Mg2+ binding site [ion binding]; other site 455488001807 G-X-G motif; other site 455488001808 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488001809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001810 active site 455488001811 phosphorylation site [posttranslational modification] 455488001812 intermolecular recognition site; other site 455488001813 dimerization interface [polypeptide binding]; other site 455488001814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001815 Walker A motif; other site 455488001816 ATP binding site [chemical binding]; other site 455488001817 Walker B motif; other site 455488001818 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488001819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488001820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488001821 non-specific DNA binding site [nucleotide binding]; other site 455488001822 salt bridge; other site 455488001823 sequence-specific DNA binding site [nucleotide binding]; other site 455488001824 Competence protein A; Region: Competence_A; pfam11104 455488001825 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488001826 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 455488001827 Pilus assembly protein, PilO; Region: PilO; pfam04350 455488001828 Pilus assembly protein, PilP; Region: PilP; pfam04351 455488001829 AMIN domain; Region: AMIN; pfam11741 455488001830 AMIN domain; Region: AMIN; pfam11741 455488001831 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 455488001832 Secretin and TonB N terminus short domain; Region: STN; pfam07660 455488001833 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 455488001834 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 455488001835 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 455488001836 elongation factor P; Validated; Region: PRK00529 455488001837 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 455488001838 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 455488001839 RNA binding site [nucleotide binding]; other site 455488001840 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 455488001841 RNA binding site [nucleotide binding]; other site 455488001842 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 455488001843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488001844 carboxyltransferase (CT) interaction site; other site 455488001845 biotinylation site [posttranslational modification]; other site 455488001846 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 455488001847 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488001848 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488001849 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 455488001850 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 455488001851 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488001852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 455488001853 Family of unknown function (DUF490); Region: DUF490; pfam04357 455488001854 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488001855 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488001856 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 455488001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488001858 exopolyphosphatase; Region: exo_poly_only; TIGR03706 455488001859 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 455488001860 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 455488001861 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 455488001862 TolB amino-terminal domain; Region: TolB_N; pfam04052 455488001863 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488001864 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488001865 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488001866 TonB C terminal; Region: TonB_2; pfam13103 455488001867 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 455488001868 TolR protein; Region: tolR; TIGR02801 455488001869 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 455488001870 glutamate racemase; Provisional; Region: PRK00865 455488001871 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 455488001872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488001873 Walker A/P-loop; other site 455488001874 ATP binding site [chemical binding]; other site 455488001875 Q-loop/lid; other site 455488001876 ABC transporter signature motif; other site 455488001877 Walker B; other site 455488001878 D-loop; other site 455488001879 H-loop/switch region; other site 455488001880 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 455488001881 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488001882 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 455488001883 C-terminal peptidase (prc); Region: prc; TIGR00225 455488001884 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 455488001885 protein binding site [polypeptide binding]; other site 455488001886 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 455488001887 Catalytic dyad [active] 455488001888 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 455488001889 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488001890 DXD motif; other site 455488001891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488001892 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 455488001893 Coenzyme A binding pocket [chemical binding]; other site 455488001894 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 455488001895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488001896 motif II; other site 455488001897 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 455488001898 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 455488001899 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 455488001900 P loop; other site 455488001901 GTP binding site [chemical binding]; other site 455488001902 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 455488001903 AAA domain; Region: AAA_23; pfam13476 455488001904 Walker A/P-loop; other site 455488001905 ATP binding site [chemical binding]; other site 455488001906 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 455488001907 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 455488001908 Q-loop/lid; other site 455488001909 ABC transporter signature motif; other site 455488001910 Walker B; other site 455488001911 D-loop; other site 455488001912 H-loop/switch region; other site 455488001913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488001914 dimerization interface [polypeptide binding]; other site 455488001915 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488001916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488001917 dimer interface [polypeptide binding]; other site 455488001918 putative CheW interface [polypeptide binding]; other site 455488001919 Competence protein A; Region: Competence_A; pfam11104 455488001920 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 455488001921 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 455488001922 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 455488001923 type II secretion system protein J; Region: gspJ; TIGR01711 455488001924 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 455488001925 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 455488001926 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 455488001927 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 455488001928 type II secretion system protein F; Region: GspF; TIGR02120 455488001929 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488001930 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488001931 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488001932 type II secretion system protein E; Region: type_II_gspE; TIGR02533 455488001933 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 455488001934 Walker A motif; other site 455488001935 ATP binding site [chemical binding]; other site 455488001936 Walker B motif; other site 455488001937 type II secretion system protein D; Region: type_II_gspD; TIGR02517 455488001938 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 455488001939 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 455488001940 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 455488001941 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 455488001942 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 455488001943 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488001944 protein binding site [polypeptide binding]; other site 455488001945 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488001946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488001947 active site 455488001948 phosphorylation site [posttranslational modification] 455488001949 intermolecular recognition site; other site 455488001950 dimerization interface [polypeptide binding]; other site 455488001951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488001952 Walker A motif; other site 455488001953 ATP binding site [chemical binding]; other site 455488001954 Walker B motif; other site 455488001955 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488001956 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 455488001957 transcription termination factor Rho; Provisional; Region: rho; PRK09376 455488001958 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 455488001959 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 455488001960 RNA binding site [nucleotide binding]; other site 455488001961 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 455488001962 multimer interface [polypeptide binding]; other site 455488001963 Walker A motif; other site 455488001964 ATP binding site [chemical binding]; other site 455488001965 Walker B motif; other site 455488001966 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 455488001967 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 455488001968 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 455488001969 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 455488001970 nucleotide binding pocket [chemical binding]; other site 455488001971 K-X-D-G motif; other site 455488001972 catalytic site [active] 455488001973 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 455488001974 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 455488001975 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 455488001976 Dimer interface [polypeptide binding]; other site 455488001977 BRCT sequence motif; other site 455488001978 acylphosphatase; Provisional; Region: PRK14441 455488001979 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 455488001980 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 455488001981 B12 binding site [chemical binding]; other site 455488001982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488001983 FeS/SAM binding site; other site 455488001984 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 455488001985 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 455488001986 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 455488001987 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 455488001988 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 455488001989 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 455488001990 Transcriptional regulator; Region: Rrf2; cl17282 455488001991 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 455488001992 IHF dimer interface [polypeptide binding]; other site 455488001993 IHF - DNA interface [nucleotide binding]; other site 455488001994 FHIPEP family; Region: FHIPEP; pfam00771 455488001995 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 455488001996 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 455488001997 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 455488001998 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 455488001999 FliP family; Region: FliP; cl00593 455488002000 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 455488002001 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 455488002002 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 455488002003 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 455488002004 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 455488002005 dinuclear metal binding motif [ion binding]; other site 455488002006 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 455488002007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488002008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488002009 DNA binding residues [nucleotide binding] 455488002010 dimerization interface [polypeptide binding]; other site 455488002011 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 455488002012 histidinol dehydrogenase; Region: hisD; TIGR00069 455488002013 NAD binding site [chemical binding]; other site 455488002014 dimerization interface [polypeptide binding]; other site 455488002015 product binding site; other site 455488002016 substrate binding site [chemical binding]; other site 455488002017 zinc binding site [ion binding]; other site 455488002018 catalytic residues [active] 455488002019 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 455488002020 putative active site pocket [active] 455488002021 4-fold oligomerization interface [polypeptide binding]; other site 455488002022 metal binding residues [ion binding]; metal-binding site 455488002023 3-fold/trimer interface [polypeptide binding]; other site 455488002024 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 455488002025 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 455488002026 putative active site [active] 455488002027 oxyanion strand; other site 455488002028 catalytic triad [active] 455488002029 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 455488002030 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 455488002031 catalytic residues [active] 455488002032 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 455488002033 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 455488002034 substrate binding site [chemical binding]; other site 455488002035 glutamase interaction surface [polypeptide binding]; other site 455488002036 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 455488002037 Yqey-like protein; Region: YqeY; pfam09424 455488002038 DNA primase, catalytic core; Region: dnaG; TIGR01391 455488002039 CHC2 zinc finger; Region: zf-CHC2; cl17510 455488002040 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 455488002041 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 455488002042 active site 455488002043 metal binding site [ion binding]; metal-binding site 455488002044 interdomain interaction site; other site 455488002045 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 455488002046 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 455488002047 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 455488002048 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 455488002049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488002050 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 455488002051 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488002052 DNA binding residues [nucleotide binding] 455488002053 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 455488002054 Putative zinc ribbon domain; Region: DUF164; pfam02591 455488002055 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 455488002056 RNA/DNA hybrid binding site [nucleotide binding]; other site 455488002057 active site 455488002058 Predicted membrane protein [Function unknown]; Region: COG1584 455488002059 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 455488002060 active site 455488002061 catalytic residues [active] 455488002062 metal binding site [ion binding]; metal-binding site 455488002063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488002064 HSP70 interaction site [polypeptide binding]; other site 455488002065 primosome assembly protein PriA; Validated; Region: PRK05580 455488002066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488002067 ATP binding site [chemical binding]; other site 455488002068 putative Mg++ binding site [ion binding]; other site 455488002069 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 455488002070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488002071 recombination factor protein RarA; Reviewed; Region: PRK13342 455488002072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002073 Walker A motif; other site 455488002074 ATP binding site [chemical binding]; other site 455488002075 Walker B motif; other site 455488002076 arginine finger; other site 455488002077 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 455488002078 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 455488002079 ATP-NAD kinase; Region: NAD_kinase; pfam01513 455488002080 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 455488002081 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 455488002082 Walker A/P-loop; other site 455488002083 ATP binding site [chemical binding]; other site 455488002084 Q-loop/lid; other site 455488002085 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 455488002086 ABC transporter signature motif; other site 455488002087 Walker B; other site 455488002088 D-loop; other site 455488002089 H-loop/switch region; other site 455488002090 Protein phosphatase 2C; Region: PP2C; pfam00481 455488002091 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 455488002092 active site 455488002093 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488002094 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488002095 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 455488002096 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 455488002097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 455488002098 nucleotide binding region [chemical binding]; other site 455488002099 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 455488002100 SEC-C motif; Region: SEC-C; pfam02810 455488002101 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 455488002102 minor groove reading motif; other site 455488002103 helix-hairpin-helix signature motif; other site 455488002104 substrate binding pocket [chemical binding]; other site 455488002105 active site 455488002106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 455488002107 AsnC family; Region: AsnC_trans_reg; pfam01037 455488002108 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488002109 active site 455488002110 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 455488002111 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 455488002112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 455488002113 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 455488002114 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 455488002115 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 455488002116 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 455488002117 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 455488002118 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 455488002119 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 455488002120 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 455488002121 transposase/IS protein; Provisional; Region: PRK09183 455488002122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002123 Walker A motif; other site 455488002124 ATP binding site [chemical binding]; other site 455488002125 Walker B motif; other site 455488002126 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 455488002127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488002128 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 455488002129 DNA binding residues [nucleotide binding] 455488002130 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 455488002131 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488002132 active site 455488002133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488002134 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 455488002135 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 455488002136 FAD binding pocket [chemical binding]; other site 455488002137 conserved FAD binding motif [chemical binding]; other site 455488002138 phosphate binding motif [ion binding]; other site 455488002139 beta-alpha-beta structure motif; other site 455488002140 NAD binding pocket [chemical binding]; other site 455488002141 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 455488002142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 455488002143 active site 455488002144 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 455488002145 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488002146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488002147 active site 455488002148 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488002149 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 455488002150 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488002151 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488002152 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 455488002153 MarR family; Region: MarR_2; pfam12802 455488002154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488002155 dimer interface [polypeptide binding]; other site 455488002156 phosphorylation site [posttranslational modification] 455488002157 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 455488002158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488002159 ATP binding site [chemical binding]; other site 455488002160 Mg2+ binding site [ion binding]; other site 455488002161 G-X-G motif; other site 455488002162 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 455488002163 substrate binding site [chemical binding]; other site 455488002164 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 455488002165 putative deacylase active site [active] 455488002166 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 455488002167 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 455488002168 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 455488002169 Predicted permeases [General function prediction only]; Region: RarD; COG2962 455488002170 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488002171 Ligand Binding Site [chemical binding]; other site 455488002172 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 455488002173 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 455488002174 putative active site [active] 455488002175 putative FMN binding site [chemical binding]; other site 455488002176 putative substrate binding site [chemical binding]; other site 455488002177 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 455488002178 Ferritin-like domain; Region: Ferritin; pfam00210 455488002179 binuclear metal center [ion binding]; other site 455488002180 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 455488002181 Cysteine-rich domain; Region: CCG; pfam02754 455488002182 Cysteine-rich domain; Region: CCG; pfam02754 455488002183 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 455488002184 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 455488002185 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 455488002186 active site 455488002187 catalytic site [active] 455488002188 substrate binding site [chemical binding]; other site 455488002189 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 455488002190 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 455488002191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488002192 ligand binding site [chemical binding]; other site 455488002193 flexible hinge region; other site 455488002194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 455488002195 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 455488002196 metal binding triad; other site 455488002197 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 455488002198 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 455488002199 active site 455488002200 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 455488002201 Response regulator receiver domain; Region: Response_reg; pfam00072 455488002202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002203 active site 455488002204 phosphorylation site [posttranslational modification] 455488002205 intermolecular recognition site; other site 455488002206 dimerization interface [polypeptide binding]; other site 455488002207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488002208 NAD(P) binding site [chemical binding]; other site 455488002209 active site 455488002210 Domain of unknown function DUF21; Region: DUF21; pfam01595 455488002211 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 455488002212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 455488002213 Transporter associated domain; Region: CorC_HlyC; smart01091 455488002214 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 455488002215 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488002217 S-adenosylmethionine binding site [chemical binding]; other site 455488002218 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 455488002219 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 455488002220 TPP-binding site [chemical binding]; other site 455488002221 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 455488002222 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 455488002223 E3 interaction surface; other site 455488002224 lipoyl attachment site [posttranslational modification]; other site 455488002225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 455488002226 Protein of unknown function DUF72; Region: DUF72; pfam01904 455488002227 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 455488002228 active site 455488002229 DNA binding site [nucleotide binding] 455488002230 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 455488002231 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 455488002232 DNA binding site [nucleotide binding] 455488002233 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 455488002234 nucleotide binding site [chemical binding]; other site 455488002235 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 455488002236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488002237 ATP binding site [chemical binding]; other site 455488002238 putative Mg++ binding site [ion binding]; other site 455488002239 nucleotide binding region [chemical binding]; other site 455488002240 helicase superfamily c-terminal domain; Region: HELICc; smart00490 455488002241 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 455488002242 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 455488002243 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 455488002244 putative dimer interface [polypeptide binding]; other site 455488002245 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 455488002246 Clp amino terminal domain; Region: Clp_N; pfam02861 455488002247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002248 Walker A motif; other site 455488002249 ATP binding site [chemical binding]; other site 455488002250 Walker B motif; other site 455488002251 arginine finger; other site 455488002252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002253 Walker A motif; other site 455488002254 ATP binding site [chemical binding]; other site 455488002255 Walker B motif; other site 455488002256 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 455488002257 Uncharacterized conserved protein [Function unknown]; Region: COG2127 455488002258 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 455488002259 structural tetrad; other site 455488002260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 455488002261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 455488002262 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 455488002263 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 455488002264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488002265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488002266 DNA binding residues [nucleotide binding] 455488002267 Putative zinc-finger; Region: zf-HC2; pfam13490 455488002268 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 455488002269 heme-binding residues [chemical binding]; other site 455488002270 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488002271 molybdopterin cofactor binding site; other site 455488002272 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488002273 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 455488002274 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 455488002275 4Fe-4S binding domain; Region: Fer4_2; pfam12797 455488002276 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488002277 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 455488002278 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 455488002279 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 455488002280 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 455488002281 Cu(I) binding site [ion binding]; other site 455488002282 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 455488002283 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 455488002284 Cytochrome c; Region: Cytochrom_C; pfam00034 455488002285 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 455488002286 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 455488002287 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 455488002288 Subunit I/III interface [polypeptide binding]; other site 455488002289 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 455488002290 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 455488002291 thiamine pyrophosphate protein; Provisional; Region: PRK08273 455488002292 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 455488002293 PYR/PP interface [polypeptide binding]; other site 455488002294 dimer interface [polypeptide binding]; other site 455488002295 tetramer interface [polypeptide binding]; other site 455488002296 TPP binding site [chemical binding]; other site 455488002297 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 455488002298 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 455488002299 TPP-binding site [chemical binding]; other site 455488002300 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 455488002301 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 455488002302 metal binding site [ion binding]; metal-binding site 455488002303 substrate binding pocket [chemical binding]; other site 455488002304 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 455488002305 FAD binding domain; Region: FAD_binding_4; pfam01565 455488002306 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488002307 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 455488002308 putative ADP-ribose binding site [chemical binding]; other site 455488002309 putative active site [active] 455488002310 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488002311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002312 active site 455488002313 phosphorylation site [posttranslational modification] 455488002314 intermolecular recognition site; other site 455488002315 dimerization interface [polypeptide binding]; other site 455488002316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002317 Walker A motif; other site 455488002318 ATP binding site [chemical binding]; other site 455488002319 Walker B motif; other site 455488002320 arginine finger; other site 455488002321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488002322 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 455488002323 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 455488002324 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 455488002325 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 455488002326 active site 455488002327 DNA binding site [nucleotide binding] 455488002328 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 455488002329 DNA binding site [nucleotide binding] 455488002330 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 455488002331 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 455488002332 active site 455488002333 dimer interface [polypeptide binding]; other site 455488002334 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 455488002335 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 455488002336 active site 455488002337 FMN binding site [chemical binding]; other site 455488002338 substrate binding site [chemical binding]; other site 455488002339 3Fe-4S cluster binding site [ion binding]; other site 455488002340 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 455488002341 domain interface; other site 455488002342 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 455488002343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488002344 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 455488002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488002346 putative substrate translocation pore; other site 455488002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488002348 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 455488002349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488002350 FeS/SAM binding site; other site 455488002351 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 455488002352 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 455488002353 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 455488002354 4Fe-4S binding domain; Region: Fer4; pfam00037 455488002355 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 455488002356 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488002357 molybdopterin cofactor binding site; other site 455488002358 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488002359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488002360 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 455488002361 molybdopterin cofactor binding site; other site 455488002362 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 455488002363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 455488002364 Walker A motif; other site 455488002365 ATP binding site [chemical binding]; other site 455488002366 Family description; Region: UvrD_C_2; pfam13538 455488002367 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 455488002368 dimer interface [polypeptide binding]; other site 455488002369 catalytic triad [active] 455488002370 peroxidatic and resolving cysteines [active] 455488002371 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 455488002372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488002373 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 455488002374 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488002375 ABC transporter; Region: ABC_tran_2; pfam12848 455488002376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488002377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488002378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488002379 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 455488002380 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 455488002381 Glutamate binding site [chemical binding]; other site 455488002382 NAD binding site [chemical binding]; other site 455488002383 catalytic residues [active] 455488002384 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002386 active site 455488002387 phosphorylation site [posttranslational modification] 455488002388 intermolecular recognition site; other site 455488002389 dimerization interface [polypeptide binding]; other site 455488002390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002391 Walker A motif; other site 455488002392 ATP binding site [chemical binding]; other site 455488002393 Walker B motif; other site 455488002394 arginine finger; other site 455488002395 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488002396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488002397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488002398 dimer interface [polypeptide binding]; other site 455488002399 phosphorylation site [posttranslational modification] 455488002400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488002401 ATP binding site [chemical binding]; other site 455488002402 Mg2+ binding site [ion binding]; other site 455488002403 G-X-G motif; other site 455488002404 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488002405 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 455488002406 Walker A/P-loop; other site 455488002407 ATP binding site [chemical binding]; other site 455488002408 Q-loop/lid; other site 455488002409 ABC transporter signature motif; other site 455488002410 Walker B; other site 455488002411 D-loop; other site 455488002412 H-loop/switch region; other site 455488002413 ABC-2 type transporter; Region: ABC2_membrane; cl17235 455488002414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 455488002415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 455488002416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488002417 ATP binding site [chemical binding]; other site 455488002418 putative Mg++ binding site [ion binding]; other site 455488002419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488002420 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 455488002421 nucleotide binding region [chemical binding]; other site 455488002422 ATP-binding site [chemical binding]; other site 455488002423 HRDC domain; Region: HRDC; pfam00570 455488002424 YaeQ protein; Region: YaeQ; cl01913 455488002425 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 455488002426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488002427 dimerization interface [polypeptide binding]; other site 455488002428 putative Zn2+ binding site [ion binding]; other site 455488002429 putative DNA binding site [nucleotide binding]; other site 455488002430 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 455488002431 putative ABC transporter; Region: ycf24; CHL00085 455488002432 FeS assembly ATPase SufC; Region: sufC; TIGR01978 455488002433 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 455488002434 Walker A/P-loop; other site 455488002435 ATP binding site [chemical binding]; other site 455488002436 Q-loop/lid; other site 455488002437 ABC transporter signature motif; other site 455488002438 Walker B; other site 455488002439 D-loop; other site 455488002440 H-loop/switch region; other site 455488002441 FeS assembly protein SufD; Region: sufD; TIGR01981 455488002442 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 455488002443 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 455488002444 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 455488002445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488002446 catalytic residue [active] 455488002447 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 455488002448 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 455488002449 trimerization site [polypeptide binding]; other site 455488002450 active site 455488002451 Domain of unknown function DUF59; Region: DUF59; cl00941 455488002452 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488002453 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488002454 phosphopeptide binding site; other site 455488002455 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 455488002456 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488002457 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488002458 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488002459 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488002460 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 455488002461 protein binding site [polypeptide binding]; other site 455488002462 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 455488002463 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 455488002464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488002465 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488002466 FtsX-like permease family; Region: FtsX; pfam02687 455488002467 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488002468 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488002469 protein binding site [polypeptide binding]; other site 455488002470 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488002471 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488002472 protein binding site [polypeptide binding]; other site 455488002473 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488002474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488002475 DNA binding residues [nucleotide binding] 455488002476 dimerization interface [polypeptide binding]; other site 455488002477 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 455488002478 Domain of unknown function (DUF222); Region: DUF222; pfam02720 455488002479 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488002480 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488002481 active site 455488002482 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 455488002483 putative rRNA binding site [nucleotide binding]; other site 455488002484 TfuA-like protein; Region: TfuA; pfam07812 455488002485 YcaO-like family; Region: YcaO; pfam02624 455488002486 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 455488002487 hypothetical protein; Provisional; Region: PRK07907 455488002488 active site 455488002489 metal binding site [ion binding]; metal-binding site 455488002490 dimer interface [polypeptide binding]; other site 455488002491 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 455488002492 homodimer interface [polypeptide binding]; other site 455488002493 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 455488002494 active site pocket [active] 455488002495 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 455488002496 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 455488002497 Repair protein; Region: Repair_PSII; pfam04536 455488002498 Repair protein; Region: Repair_PSII; cl01535 455488002499 potassium/proton antiporter; Reviewed; Region: PRK05326 455488002500 TrkA-C domain; Region: TrkA_C; pfam02080 455488002501 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 455488002502 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488002503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488002504 non-specific DNA binding site [nucleotide binding]; other site 455488002505 salt bridge; other site 455488002506 sequence-specific DNA binding site [nucleotide binding]; other site 455488002507 Cupin domain; Region: Cupin_2; pfam07883 455488002508 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002510 active site 455488002511 phosphorylation site [posttranslational modification] 455488002512 intermolecular recognition site; other site 455488002513 dimerization interface [polypeptide binding]; other site 455488002514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 455488002515 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 455488002516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488002517 active site 455488002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488002519 S-adenosylmethionine binding site [chemical binding]; other site 455488002520 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 455488002521 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 455488002522 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488002523 ligand binding site [chemical binding]; other site 455488002524 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 455488002525 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 455488002526 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 455488002527 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 455488002528 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 455488002529 active site 455488002530 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 455488002531 nucleotide binding site [chemical binding]; other site 455488002532 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 455488002533 Mechanosensitive ion channel; Region: MS_channel; pfam00924 455488002534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488002535 TPR motif; other site 455488002536 binding surface 455488002537 TPR repeat; Region: TPR_11; pfam13414 455488002538 CAAX protease self-immunity; Region: Abi; cl00558 455488002539 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 455488002540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002541 active site 455488002542 phosphorylation site [posttranslational modification] 455488002543 intermolecular recognition site; other site 455488002544 dimerization interface [polypeptide binding]; other site 455488002545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488002546 DNA binding site [nucleotide binding] 455488002547 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 455488002548 GAF domain; Region: GAF_3; pfam13492 455488002549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488002550 dimer interface [polypeptide binding]; other site 455488002551 phosphorylation site [posttranslational modification] 455488002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488002553 ATP binding site [chemical binding]; other site 455488002554 Mg2+ binding site [ion binding]; other site 455488002555 G-X-G motif; other site 455488002556 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 455488002557 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 455488002558 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488002559 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 455488002560 dimerization interface [polypeptide binding]; other site 455488002561 Protein of unknown function (DUF420); Region: DUF420; pfam04238 455488002562 ABC-2 type transporter; Region: ABC2_membrane; cl17235 455488002563 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488002564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 455488002565 Walker A/P-loop; other site 455488002566 ATP binding site [chemical binding]; other site 455488002567 Q-loop/lid; other site 455488002568 ABC transporter signature motif; other site 455488002569 Walker B; other site 455488002570 D-loop; other site 455488002571 H-loop/switch region; other site 455488002572 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 455488002573 UbiA prenyltransferase family; Region: UbiA; pfam01040 455488002574 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 455488002575 TIGR02300 family protein; Region: FYDLN_acid 455488002576 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 455488002577 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 455488002578 Ligand Binding Site [chemical binding]; other site 455488002579 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 455488002580 catalytic residue [active] 455488002581 phosphopentomutase; Provisional; Region: PRK05362 455488002582 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 455488002583 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488002584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488002585 S-adenosylmethionine binding site [chemical binding]; other site 455488002586 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 455488002587 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 455488002588 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 455488002589 [4Fe-4S] binding site [ion binding]; other site 455488002590 molybdopterin cofactor binding site; other site 455488002591 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 455488002592 molybdopterin cofactor binding site; other site 455488002593 Cytochrome c552; Region: Cytochrom_C552; pfam02335 455488002594 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 455488002595 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 455488002596 Multicopper oxidase; Region: Cu-oxidase; pfam00394 455488002597 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 455488002598 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 455488002599 Interdomain contacts; other site 455488002600 Cytokine receptor motif; other site 455488002601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 455488002602 Interdomain contacts; other site 455488002603 Cytokine receptor motif; other site 455488002604 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 455488002605 hydrophobic ligand binding site; other site 455488002606 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488002607 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 455488002608 anti sigma factor interaction site; other site 455488002609 regulatory phosphorylation site [posttranslational modification]; other site 455488002610 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 455488002611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 455488002612 ATP binding site [chemical binding]; other site 455488002613 Mg2+ binding site [ion binding]; other site 455488002614 G-X-G motif; other site 455488002615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488002616 dimerization interface [polypeptide binding]; other site 455488002617 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 455488002618 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 455488002619 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 455488002620 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488002621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488002622 dimer interface [polypeptide binding]; other site 455488002623 phosphorylation site [posttranslational modification] 455488002624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488002625 ATP binding site [chemical binding]; other site 455488002626 Mg2+ binding site [ion binding]; other site 455488002627 G-X-G motif; other site 455488002628 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002630 active site 455488002631 phosphorylation site [posttranslational modification] 455488002632 intermolecular recognition site; other site 455488002633 dimerization interface [polypeptide binding]; other site 455488002634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002635 Walker A motif; other site 455488002636 ATP binding site [chemical binding]; other site 455488002637 Walker B motif; other site 455488002638 arginine finger; other site 455488002639 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488002640 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488002641 Caspase domain; Region: Peptidase_C14; pfam00656 455488002642 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 455488002643 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 455488002644 homodimer interface [polypeptide binding]; other site 455488002645 substrate-cofactor binding pocket; other site 455488002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488002647 catalytic residue [active] 455488002648 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 455488002649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488002650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488002651 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 455488002652 acyl-activating enzyme (AAE) consensus motif; other site 455488002653 acyl-activating enzyme (AAE) consensus motif; other site 455488002654 putative AMP binding site [chemical binding]; other site 455488002655 putative active site [active] 455488002656 putative CoA binding site [chemical binding]; other site 455488002657 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 455488002658 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 455488002659 DTAP/Switch II; other site 455488002660 Switch I; other site 455488002661 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 455488002662 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 455488002663 DTAP/Switch II; other site 455488002664 Switch I; other site 455488002665 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 455488002666 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 455488002667 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488002668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 455488002669 Magnesium ion binding site [ion binding]; other site 455488002670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488002671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488002672 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 455488002673 putative effector binding pocket; other site 455488002674 dimerization interface [polypeptide binding]; other site 455488002675 Uncharacterized conserved protein [Function unknown]; Region: COG2353 455488002676 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 455488002677 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 455488002678 putative active site [active] 455488002679 metal binding site [ion binding]; metal-binding site 455488002680 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 455488002681 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 455488002682 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 455488002683 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 455488002684 active site 455488002685 catalytic site [active] 455488002686 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 455488002687 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 455488002688 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 455488002689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 455488002690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488002691 hydroxyglutarate oxidase; Provisional; Region: PRK11728 455488002692 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 455488002693 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 455488002694 tetramer interface [polypeptide binding]; other site 455488002695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488002696 catalytic residue [active] 455488002697 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 455488002698 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 455488002699 catalytic residues [active] 455488002700 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 455488002701 active site 455488002702 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 455488002703 hypothetical protein; Reviewed; Region: PRK09588 455488002704 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 455488002705 multidrug efflux protein; Reviewed; Region: PRK01766 455488002706 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 455488002707 cation binding site [ion binding]; other site 455488002708 K+ potassium transporter; Region: K_trans; cl15781 455488002709 potassium uptake protein; Region: kup; TIGR00794 455488002710 Transmembrane secretion effector; Region: MFS_3; pfam05977 455488002711 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 455488002712 active site 455488002713 putative DNA-binding cleft [nucleotide binding]; other site 455488002714 dimer interface [polypeptide binding]; other site 455488002715 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 455488002716 RuvA N terminal domain; Region: RuvA_N; pfam01330 455488002717 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 455488002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002719 Walker A motif; other site 455488002720 ATP binding site [chemical binding]; other site 455488002721 Walker B motif; other site 455488002722 arginine finger; other site 455488002723 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 455488002724 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 455488002725 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 455488002726 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 455488002727 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 455488002728 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 455488002729 putative hydrophobic ligand binding site [chemical binding]; other site 455488002730 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 455488002731 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 455488002732 nucleotide binding site [chemical binding]; other site 455488002733 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 455488002734 putative DNA binding site [nucleotide binding]; other site 455488002735 putative homodimer interface [polypeptide binding]; other site 455488002736 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 455488002737 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 455488002738 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 455488002739 hypothetical protein; Provisional; Region: PRK10621 455488002740 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 455488002741 Response regulator receiver domain; Region: Response_reg; pfam00072 455488002742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002743 active site 455488002744 phosphorylation site [posttranslational modification] 455488002745 intermolecular recognition site; other site 455488002746 dimerization interface [polypeptide binding]; other site 455488002747 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 455488002748 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 455488002749 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 455488002750 DNA binding site [nucleotide binding] 455488002751 active site 455488002752 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 455488002753 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 455488002754 AlkA N-terminal domain; Region: AlkA_N; pfam06029 455488002755 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 455488002756 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 455488002757 helix-hairpin-helix signature motif; other site 455488002758 Cupin domain; Region: Cupin_2; cl17218 455488002759 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 455488002760 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 455488002761 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 455488002762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002763 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488002764 Walker A motif; other site 455488002765 ATP binding site [chemical binding]; other site 455488002766 Walker B motif; other site 455488002767 arginine finger; other site 455488002768 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488002769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488002770 putative substrate translocation pore; other site 455488002771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488002772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488002773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488002774 dimerization interface [polypeptide binding]; other site 455488002775 Alkaline phosphatase homologues; Region: alkPPc; smart00098 455488002776 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 455488002777 active site 455488002778 dimer interface [polypeptide binding]; other site 455488002779 Alkaline phosphatase homologues; Region: alkPPc; smart00098 455488002780 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 455488002781 active site 455488002782 dimer interface [polypeptide binding]; other site 455488002783 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 455488002784 active site 455488002785 metal binding site [ion binding]; metal-binding site 455488002786 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488002787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488002788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488002789 dimer interface [polypeptide binding]; other site 455488002790 phosphorylation site [posttranslational modification] 455488002791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488002792 ATP binding site [chemical binding]; other site 455488002793 Mg2+ binding site [ion binding]; other site 455488002794 G-X-G motif; other site 455488002795 Response regulator receiver domain; Region: Response_reg; pfam00072 455488002796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488002797 active site 455488002798 phosphorylation site [posttranslational modification] 455488002799 intermolecular recognition site; other site 455488002800 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 455488002801 Peptidase family M48; Region: Peptidase_M48; pfam01435 455488002802 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 455488002803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488002804 DNA-binding site [nucleotide binding]; DNA binding site 455488002805 RNA-binding motif; other site 455488002806 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488002807 active site 455488002808 metal binding site [ion binding]; metal-binding site 455488002809 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 455488002810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488002811 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 455488002812 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 455488002813 putative active site [active] 455488002814 catalytic site [active] 455488002815 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 455488002816 putative active site [active] 455488002817 catalytic site [active] 455488002818 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 455488002819 homodimer interaction site [polypeptide binding]; other site 455488002820 cofactor binding site; other site 455488002821 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 455488002822 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 455488002823 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 455488002824 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 455488002825 putative ligand binding site [chemical binding]; other site 455488002826 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002827 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002828 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002829 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002830 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002831 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002832 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002833 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002834 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002835 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002836 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002837 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 455488002838 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 455488002839 CoA binding domain; Region: CoA_binding_2; pfam13380 455488002840 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 455488002841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 455488002842 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 455488002843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488002844 Coenzyme A binding pocket [chemical binding]; other site 455488002845 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 455488002846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 455488002847 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 455488002848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488002849 Walker A/P-loop; other site 455488002850 ATP binding site [chemical binding]; other site 455488002851 Q-loop/lid; other site 455488002852 ABC transporter signature motif; other site 455488002853 Walker B; other site 455488002854 D-loop; other site 455488002855 H-loop/switch region; other site 455488002856 TOBE domain; Region: TOBE; cl01440 455488002857 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 455488002858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488002859 putative PBP binding loops; other site 455488002860 dimer interface [polypeptide binding]; other site 455488002861 ABC-ATPase subunit interface; other site 455488002862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 455488002863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 455488002864 Helix-turn-helix domain; Region: HTH_17; pfam12728 455488002865 PBP superfamily domain; Region: PBP_like; pfam12727 455488002866 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 455488002867 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 455488002868 putative ligand binding site [chemical binding]; other site 455488002869 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 455488002870 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 455488002871 TM-ABC transporter signature motif; other site 455488002872 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 455488002873 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 455488002874 TM-ABC transporter signature motif; other site 455488002875 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 455488002876 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 455488002877 Walker A/P-loop; other site 455488002878 ATP binding site [chemical binding]; other site 455488002879 Q-loop/lid; other site 455488002880 ABC transporter signature motif; other site 455488002881 Walker B; other site 455488002882 D-loop; other site 455488002883 H-loop/switch region; other site 455488002884 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 455488002885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488002886 active site 455488002887 YCII-related domain; Region: YCII; cl00999 455488002888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 455488002889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488002890 Transcriptional regulators [Transcription]; Region: MarR; COG1846 455488002891 MarR family; Region: MarR_2; cl17246 455488002892 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 455488002893 RibD C-terminal domain; Region: RibD_C; cl17279 455488002894 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488002895 active site 455488002896 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 455488002897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 455488002898 PYR/PP interface [polypeptide binding]; other site 455488002899 dimer interface [polypeptide binding]; other site 455488002900 TPP binding site [chemical binding]; other site 455488002901 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 455488002902 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 455488002903 TPP-binding site; other site 455488002904 dimer interface [polypeptide binding]; other site 455488002905 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 455488002906 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488002907 putative ADP-binding pocket [chemical binding]; other site 455488002908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488002909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 455488002910 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 455488002911 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 455488002912 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 455488002913 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488002914 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 455488002915 Low molecular weight phosphatase family; Region: LMWPc; cd00115 455488002916 active site 455488002917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488002918 Coenzyme A binding pocket [chemical binding]; other site 455488002919 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 455488002920 arsenical-resistance protein; Region: acr3; TIGR00832 455488002921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488002922 putative DNA binding site [nucleotide binding]; other site 455488002923 putative Zn2+ binding site [ion binding]; other site 455488002924 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488002925 catalytic residues [active] 455488002926 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 455488002927 Predicted permeases [General function prediction only]; Region: COG0701 455488002928 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 455488002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488002930 S-adenosylmethionine binding site [chemical binding]; other site 455488002931 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 455488002932 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 455488002933 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 455488002934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488002935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488002936 dimerization interface [polypeptide binding]; other site 455488002937 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488002938 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488002939 active site 455488002940 DNA binding site [nucleotide binding] 455488002941 Int/Topo IB signature motif; other site 455488002942 SIR2-like domain; Region: SIR2_2; pfam13289 455488002943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488002944 AAA domain; Region: AAA_23; pfam13476 455488002945 Walker A/P-loop; other site 455488002946 ATP binding site [chemical binding]; other site 455488002947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488002948 Walker B; other site 455488002949 D-loop; other site 455488002950 H-loop/switch region; other site 455488002951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488002952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488002953 non-specific DNA binding site [nucleotide binding]; other site 455488002954 salt bridge; other site 455488002955 sequence-specific DNA binding site [nucleotide binding]; other site 455488002956 Domain of unknown function (DUF955); Region: DUF955; cl01076 455488002957 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 455488002958 Ligand Binding Site [chemical binding]; other site 455488002959 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 455488002960 TrwC relaxase; Region: TrwC; pfam08751 455488002961 AAA domain; Region: AAA_30; pfam13604 455488002962 Family description; Region: UvrD_C_2; pfam13538 455488002963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488002964 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 455488002965 Walker A motif; other site 455488002966 ATP binding site [chemical binding]; other site 455488002967 Walker B motif; other site 455488002968 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 455488002969 ParB-like nuclease domain; Region: ParB; smart00470 455488002970 Protein of unknown function (DUF2026); Region: DUF2026; pfam09641 455488002971 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 455488002972 metal ion-dependent adhesion site (MIDAS); other site 455488002973 MoxR-like ATPases [General function prediction only]; Region: COG0714 455488002974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488002975 Walker A motif; other site 455488002976 ATP binding site [chemical binding]; other site 455488002977 Walker B motif; other site 455488002978 arginine finger; other site 455488002979 hypothetical protein; Reviewed; Region: PRK00024 455488002980 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 455488002981 MPN+ (JAMM) motif; other site 455488002982 Zinc-binding site [ion binding]; other site 455488002983 ParB-like nuclease domain; Region: ParB; smart00470 455488002984 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488002985 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488002986 active site 455488002987 ATP binding site [chemical binding]; other site 455488002988 substrate binding site [chemical binding]; other site 455488002989 activation loop (A-loop); other site 455488002990 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 455488002991 Abortive infection C-terminus; Region: Abi_C; pfam14355 455488002992 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 455488002993 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 455488002994 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488002995 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488002996 catalytic residue [active] 455488002997 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 455488002998 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 455488002999 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 455488003000 DNA primase, catalytic core; Region: dnaG; TIGR01391 455488003001 CHC2 zinc finger; Region: zf-CHC2; cl17510 455488003002 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 455488003003 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 455488003004 active site 455488003005 metal binding site [ion binding]; metal-binding site 455488003006 interdomain interaction site; other site 455488003007 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 455488003008 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 455488003009 Type IV secretion system proteins; Region: T4SS; pfam07996 455488003010 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 455488003011 VirB8 protein; Region: VirB8; pfam04335 455488003012 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 455488003013 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 455488003014 VirB7 interaction site; other site 455488003015 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 455488003016 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 455488003017 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 455488003018 Walker A motif; other site 455488003019 hexamer interface [polypeptide binding]; other site 455488003020 ATP binding site [chemical binding]; other site 455488003021 Walker B motif; other site 455488003022 Bacterial PH domain; Region: DUF304; pfam03703 455488003023 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 455488003024 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 455488003025 Methyltransferase domain; Region: Methyltransf_26; pfam13659 455488003026 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 455488003027 TIGR02687 family protein; Region: TIGR02687 455488003028 PglZ domain; Region: PglZ; pfam08665 455488003029 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 455488003030 DEAD-like helicases superfamily; Region: DEXDc; smart00487 455488003031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488003032 ATP binding site [chemical binding]; other site 455488003033 putative Mg++ binding site [ion binding]; other site 455488003034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488003035 nucleotide binding region [chemical binding]; other site 455488003036 ATP-binding site [chemical binding]; other site 455488003037 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 455488003038 putative succinate dehydrogenase; Reviewed; Region: PRK12842 455488003039 Isochorismatase family; Region: Isochorismatase; pfam00857 455488003040 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 455488003041 catalytic triad [active] 455488003042 dimer interface [polypeptide binding]; other site 455488003043 conserved cis-peptide bond; other site 455488003044 4Fe-4S binding domain; Region: Fer4; cl02805 455488003045 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 455488003046 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 455488003047 FtsJ-like methyltransferase; Region: FtsJ; cl17430 455488003048 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 455488003049 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 455488003050 active site 455488003051 HIGH motif; other site 455488003052 dimer interface [polypeptide binding]; other site 455488003053 KMSKS motif; other site 455488003054 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 455488003055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488003056 putative active site [active] 455488003057 metal binding site [ion binding]; metal-binding site 455488003058 homodimer binding site [polypeptide binding]; other site 455488003059 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 455488003060 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 455488003061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 455488003062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488003063 active site 455488003064 ATP binding site [chemical binding]; other site 455488003065 substrate binding site [chemical binding]; other site 455488003066 activation loop (A-loop); other site 455488003067 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 455488003068 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 455488003069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488003070 catalytic residue [active] 455488003071 DHH family; Region: DHH; pfam01368 455488003072 endonuclease IV; Provisional; Region: PRK01060 455488003073 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 455488003074 AP (apurinic/apyrimidinic) site pocket; other site 455488003075 DNA interaction; other site 455488003076 Metal-binding active site; metal-binding site 455488003077 Fic/DOC family; Region: Fic; pfam02661 455488003078 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 455488003079 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 455488003080 homodimer interface [polypeptide binding]; other site 455488003081 substrate-cofactor binding pocket; other site 455488003082 catalytic residue [active] 455488003083 Patatin-like phospholipase; Region: Patatin; pfam01734 455488003084 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 455488003085 metal binding triad; other site 455488003086 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 455488003087 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 455488003088 metal binding triad; other site 455488003089 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 455488003090 heavy-Cys/GCP-CTERM domain protein; Region: heavy_Cys_GCP; TIGR04292 455488003091 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488003092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488003093 active site 455488003094 phosphorylation site [posttranslational modification] 455488003095 intermolecular recognition site; other site 455488003096 dimerization interface [polypeptide binding]; other site 455488003097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488003098 Walker A motif; other site 455488003099 ATP binding site [chemical binding]; other site 455488003100 Walker B motif; other site 455488003101 arginine finger; other site 455488003102 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488003103 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 455488003104 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 455488003105 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 455488003106 active site 455488003107 catalytic site [active] 455488003108 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 455488003109 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 455488003110 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 455488003111 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 455488003112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 455488003113 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 455488003114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 455488003115 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 455488003116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488003117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003118 NAD(P) binding site [chemical binding]; other site 455488003119 active site 455488003120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003121 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 455488003122 NAD(P) binding site [chemical binding]; other site 455488003123 active site 455488003124 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 455488003125 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 455488003126 putative NAD(P) binding site [chemical binding]; other site 455488003127 catalytic Zn binding site [ion binding]; other site 455488003128 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 455488003129 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 455488003130 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 455488003131 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488003132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 455488003134 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 455488003135 Domain of unknown function DUF20; Region: UPF0118; pfam01594 455488003136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 455488003137 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 455488003138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 455488003139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488003140 Walker A/P-loop; other site 455488003141 ATP binding site [chemical binding]; other site 455488003142 Q-loop/lid; other site 455488003143 ABC transporter signature motif; other site 455488003144 Walker B; other site 455488003145 D-loop; other site 455488003146 H-loop/switch region; other site 455488003147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488003148 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 455488003149 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 455488003150 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 455488003151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488003152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488003153 DNA binding residues [nucleotide binding] 455488003154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003155 malonic semialdehyde reductase; Provisional; Region: PRK10538 455488003156 NAD(P) binding site [chemical binding]; other site 455488003157 active site 455488003158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488003159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488003160 dimerization interface [polypeptide binding]; other site 455488003161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488003162 dimer interface [polypeptide binding]; other site 455488003163 phosphorylation site [posttranslational modification] 455488003164 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 455488003165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488003166 ATP binding site [chemical binding]; other site 455488003167 Mg2+ binding site [ion binding]; other site 455488003168 G-X-G motif; other site 455488003169 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003170 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488003171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488003172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488003173 active site 455488003174 ATP binding site [chemical binding]; other site 455488003175 substrate binding site [chemical binding]; other site 455488003176 activation loop (A-loop); other site 455488003177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 455488003178 Uncharacterized conserved protein [Function unknown]; Region: COG1543 455488003179 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 455488003180 active site 455488003181 substrate binding site [chemical binding]; other site 455488003182 catalytic site [active] 455488003183 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 455488003184 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 455488003185 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 455488003186 dimer interface [polypeptide binding]; other site 455488003187 putative anticodon binding site; other site 455488003188 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 455488003189 motif 1; other site 455488003190 active site 455488003191 motif 2; other site 455488003192 motif 3; other site 455488003193 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 455488003194 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488003195 FtsX-like permease family; Region: FtsX; pfam02687 455488003196 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 455488003197 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488003198 Walker A/P-loop; other site 455488003199 ATP binding site [chemical binding]; other site 455488003200 Q-loop/lid; other site 455488003201 ABC transporter signature motif; other site 455488003202 Walker B; other site 455488003203 D-loop; other site 455488003204 H-loop/switch region; other site 455488003205 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003206 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 455488003207 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003208 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003209 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003210 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 455488003211 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488003212 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 455488003213 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 455488003214 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 455488003215 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 455488003216 trimer interface [polypeptide binding]; other site 455488003217 active site 455488003218 UDP-GlcNAc binding site [chemical binding]; other site 455488003219 lipid binding site [chemical binding]; lipid-binding site 455488003220 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 455488003221 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 455488003222 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 455488003223 active site 455488003224 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 455488003225 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 455488003226 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 455488003227 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 455488003228 substrate binding site [chemical binding]; other site 455488003229 active site 455488003230 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 455488003231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488003232 FeS/SAM binding site; other site 455488003233 HemN C-terminal domain; Region: HemN_C; pfam06969 455488003234 ferrochelatase; Reviewed; Region: hemH; PRK00035 455488003235 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 455488003236 C-terminal domain interface [polypeptide binding]; other site 455488003237 active site 455488003238 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 455488003239 active site 455488003240 N-terminal domain interface [polypeptide binding]; other site 455488003241 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488003242 HSP70 interaction site [polypeptide binding]; other site 455488003243 TPR repeat; Region: TPR_11; pfam13414 455488003244 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 455488003245 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 455488003246 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 455488003247 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 455488003248 generic binding surface II; other site 455488003249 generic binding surface I; other site 455488003250 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 455488003251 Response regulator receiver domain; Region: Response_reg; pfam00072 455488003252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488003253 active site 455488003254 phosphorylation site [posttranslational modification] 455488003255 intermolecular recognition site; other site 455488003256 dimerization interface [polypeptide binding]; other site 455488003257 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 455488003258 substrate binding pocket [chemical binding]; other site 455488003259 aspartate-rich region 1; other site 455488003260 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 455488003261 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 455488003262 TPP-binding site; other site 455488003263 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 455488003264 PYR/PP interface [polypeptide binding]; other site 455488003265 dimer interface [polypeptide binding]; other site 455488003266 TPP binding site [chemical binding]; other site 455488003267 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 455488003268 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 455488003269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488003270 RNA binding surface [nucleotide binding]; other site 455488003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488003272 S-adenosylmethionine binding site [chemical binding]; other site 455488003273 ribosome maturation protein RimP; Reviewed; Region: PRK00092 455488003274 Sm and related proteins; Region: Sm_like; cl00259 455488003275 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 455488003276 putative oligomer interface [polypeptide binding]; other site 455488003277 putative RNA binding site [nucleotide binding]; other site 455488003278 NusA N-terminal domain; Region: NusA_N; pfam08529 455488003279 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 455488003280 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 455488003281 RNA binding site [nucleotide binding]; other site 455488003282 homodimer interface [polypeptide binding]; other site 455488003283 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 455488003284 G-X-X-G motif; other site 455488003285 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 455488003286 G-X-X-G motif; other site 455488003287 Protein of unknown function (DUF448); Region: DUF448; pfam04296 455488003288 putative RNA binding cleft [nucleotide binding]; other site 455488003289 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 455488003290 translation initiation factor IF-2; Region: IF-2; TIGR00487 455488003291 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 455488003292 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 455488003293 G1 box; other site 455488003294 putative GEF interaction site [polypeptide binding]; other site 455488003295 GTP/Mg2+ binding site [chemical binding]; other site 455488003296 Switch I region; other site 455488003297 G2 box; other site 455488003298 G3 box; other site 455488003299 Switch II region; other site 455488003300 G4 box; other site 455488003301 G5 box; other site 455488003302 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 455488003303 Translation-initiation factor 2; Region: IF-2; pfam11987 455488003304 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 455488003305 Protein of unknown function (DUF503); Region: DUF503; pfam04456 455488003306 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 455488003307 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 455488003308 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 455488003309 RNA binding site [nucleotide binding]; other site 455488003310 active site 455488003311 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 455488003312 16S/18S rRNA binding site [nucleotide binding]; other site 455488003313 S13e-L30e interaction site [polypeptide binding]; other site 455488003314 25S rRNA binding site [nucleotide binding]; other site 455488003315 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 455488003316 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 455488003317 RNase E interface [polypeptide binding]; other site 455488003318 trimer interface [polypeptide binding]; other site 455488003319 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 455488003320 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 455488003321 RNase E interface [polypeptide binding]; other site 455488003322 trimer interface [polypeptide binding]; other site 455488003323 active site 455488003324 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 455488003325 putative nucleic acid binding region [nucleotide binding]; other site 455488003326 G-X-X-G motif; other site 455488003327 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 455488003328 RNA binding site [nucleotide binding]; other site 455488003329 domain interface; other site 455488003330 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 455488003331 trimer interface [polypeptide binding]; other site 455488003332 active site 455488003333 adenylosuccinate lyase; Provisional; Region: PRK07492 455488003334 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 455488003335 tetramer interface [polypeptide binding]; other site 455488003336 active site 455488003337 GAF domain; Region: GAF; cl17456 455488003338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488003339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488003340 dimer interface [polypeptide binding]; other site 455488003341 phosphorylation site [posttranslational modification] 455488003342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488003343 ATP binding site [chemical binding]; other site 455488003344 Mg2+ binding site [ion binding]; other site 455488003345 G-X-G motif; other site 455488003346 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 455488003347 ATP binding site [chemical binding]; other site 455488003348 active site 455488003349 substrate binding site [chemical binding]; other site 455488003350 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 455488003351 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 455488003352 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488003353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488003354 protein binding site [polypeptide binding]; other site 455488003355 phosphoglycolate phosphatase; Provisional; Region: PRK13222 455488003356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488003357 motif II; other site 455488003358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488003359 dimerization interface [polypeptide binding]; other site 455488003360 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 455488003361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488003362 Zn2+ binding site [ion binding]; other site 455488003363 Mg2+ binding site [ion binding]; other site 455488003364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488003365 active site 455488003366 phosphorylation site [posttranslational modification] 455488003367 intermolecular recognition site; other site 455488003368 dimerization interface [polypeptide binding]; other site 455488003369 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 455488003370 MoaE interaction surface [polypeptide binding]; other site 455488003371 MoeB interaction surface [polypeptide binding]; other site 455488003372 thiocarboxylated glycine; other site 455488003373 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 455488003374 MoaE homodimer interface [polypeptide binding]; other site 455488003375 MoaD interaction [polypeptide binding]; other site 455488003376 active site residues [active] 455488003377 RIP metalloprotease RseP; Region: TIGR00054 455488003378 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 455488003379 active site 455488003380 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 455488003381 protein binding site [polypeptide binding]; other site 455488003382 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 455488003383 putative substrate binding region [chemical binding]; other site 455488003384 AMMECR1; Region: AMMECR1; pfam01871 455488003385 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 455488003386 nudix motif; other site 455488003387 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 455488003388 active site clefts [active] 455488003389 zinc binding site [ion binding]; other site 455488003390 dimer interface [polypeptide binding]; other site 455488003391 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488003392 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488003393 active site 455488003394 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 455488003395 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 455488003396 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 455488003397 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 455488003398 EamA-like transporter family; Region: EamA; pfam00892 455488003399 EamA-like transporter family; Region: EamA; pfam00892 455488003400 PAS fold; Region: PAS_4; pfam08448 455488003401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 455488003402 putative active site [active] 455488003403 heme pocket [chemical binding]; other site 455488003404 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488003405 PAS domain; Region: PAS; smart00091 455488003406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488003407 dimer interface [polypeptide binding]; other site 455488003408 phosphorylation site [posttranslational modification] 455488003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488003410 ATP binding site [chemical binding]; other site 455488003411 Mg2+ binding site [ion binding]; other site 455488003412 G-X-G motif; other site 455488003413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488003414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488003415 active site 455488003416 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 455488003417 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 455488003418 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488003419 active site 455488003420 ATP binding site [chemical binding]; other site 455488003421 substrate binding site [chemical binding]; other site 455488003422 activation loop (A-loop); other site 455488003423 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 455488003424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488003425 active site 455488003426 phosphorylation site [posttranslational modification] 455488003427 intermolecular recognition site; other site 455488003428 dimerization interface [polypeptide binding]; other site 455488003429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488003430 Zn2+ binding site [ion binding]; other site 455488003431 Mg2+ binding site [ion binding]; other site 455488003432 transcription termination factor Rho; Provisional; Region: PRK12608 455488003433 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488003434 Walker A motif; other site 455488003435 ATP binding site [chemical binding]; other site 455488003436 Walker B motif; other site 455488003437 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 455488003438 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 455488003439 oligomer interface [polypeptide binding]; other site 455488003440 tandem repeat interface [polypeptide binding]; other site 455488003441 active site residues [active] 455488003442 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 455488003443 tandem repeat interface [polypeptide binding]; other site 455488003444 oligomer interface [polypeptide binding]; other site 455488003445 active site residues [active] 455488003446 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 455488003447 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 455488003448 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 455488003449 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 455488003450 active site 455488003451 Zn binding site [ion binding]; other site 455488003452 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488003453 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488003454 phosphopeptide binding site; other site 455488003455 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 455488003456 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 455488003457 NAD(P) binding site [chemical binding]; other site 455488003458 catalytic residues [active] 455488003459 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 455488003460 putative active site [active] 455488003461 putative metal binding site [ion binding]; other site 455488003462 Uncharacterized conserved protein [Function unknown]; Region: COG3342 455488003463 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 455488003464 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 455488003465 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 455488003466 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 455488003467 dimer interface [polypeptide binding]; other site 455488003468 decamer (pentamer of dimers) interface [polypeptide binding]; other site 455488003469 catalytic triad [active] 455488003470 peroxidatic and resolving cysteines [active] 455488003471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488003472 non-specific DNA binding site [nucleotide binding]; other site 455488003473 salt bridge; other site 455488003474 sequence-specific DNA binding site [nucleotide binding]; other site 455488003475 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488003476 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488003477 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 455488003478 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355 455488003479 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488003480 Haemolysin-III related; Region: HlyIII; pfam03006 455488003481 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 455488003482 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 455488003483 G1 box; other site 455488003484 GTP/Mg2+ binding site [chemical binding]; other site 455488003485 G2 box; other site 455488003486 Switch I region; other site 455488003487 G3 box; other site 455488003488 Switch II region; other site 455488003489 G4 box; other site 455488003490 G5 box; other site 455488003491 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 455488003492 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 455488003493 active site pocket [active] 455488003494 cleavage site 455488003495 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 455488003496 active site 455488003497 catalytic residues [active] 455488003498 DNA binding site [nucleotide binding] 455488003499 Int/Topo IB signature motif; other site 455488003500 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 455488003501 T5orf172 domain; Region: T5orf172; pfam10544 455488003502 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 455488003503 HNH endonuclease; Region: HNH_3; pfam13392 455488003504 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 455488003505 Phage terminase, small subunit; Region: Terminase_4; cl01525 455488003506 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 455488003507 Phage portal protein; Region: Phage_portal; pfam04860 455488003508 Phage-related protein [Function unknown]; Region: COG4695; cl01923 455488003509 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 455488003510 oligomer interface [polypeptide binding]; other site 455488003511 active site residues [active] 455488003512 Phage capsid family; Region: Phage_capsid; pfam05065 455488003513 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 455488003514 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 455488003515 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 455488003516 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 455488003517 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 455488003518 Putative phage tail protein; Region: Phage-tail_3; pfam13550 455488003519 secreted effector protein PipB2; Provisional; Region: PRK15196 455488003520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 455488003521 protein-splicing catalytic site; other site 455488003522 thioester formation/cholesterol transfer; other site 455488003523 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 455488003524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488003525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488003526 S-adenosylmethionine binding site [chemical binding]; other site 455488003527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488003528 dimerization interface [polypeptide binding]; other site 455488003529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488003530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488003531 dimer interface [polypeptide binding]; other site 455488003532 putative CheW interface [polypeptide binding]; other site 455488003533 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 455488003534 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 455488003535 putative NAD(P) binding site [chemical binding]; other site 455488003536 putative substrate binding site [chemical binding]; other site 455488003537 catalytic Zn binding site [ion binding]; other site 455488003538 structural Zn binding site [ion binding]; other site 455488003539 dimer interface [polypeptide binding]; other site 455488003540 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 455488003541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003542 NAD(P) binding site [chemical binding]; other site 455488003543 active site 455488003544 Male sterility protein; Region: NAD_binding_4; pfam07993 455488003545 NAD(P) binding site [chemical binding]; other site 455488003546 active site 455488003547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003548 active site 455488003549 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 455488003550 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 455488003551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488003552 acyl-activating enzyme (AAE) consensus motif; other site 455488003553 AMP binding site [chemical binding]; other site 455488003554 active site 455488003555 CoA binding site [chemical binding]; other site 455488003556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 455488003557 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488003558 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 455488003559 putative acyl-acceptor binding pocket; other site 455488003560 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 455488003561 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 455488003562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488003563 motif II; other site 455488003564 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 455488003565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003566 NAD(P) binding site [chemical binding]; other site 455488003567 active site 455488003568 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 455488003569 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 455488003570 putative [4Fe-4S] binding site [ion binding]; other site 455488003571 putative molybdopterin cofactor binding site [chemical binding]; other site 455488003572 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 455488003573 putative molybdopterin cofactor binding site; other site 455488003574 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 455488003575 Low-spin heme binding site [chemical binding]; other site 455488003576 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 455488003577 D-pathway; other site 455488003578 Putative water exit pathway; other site 455488003579 Binuclear center (active site) [active] 455488003580 K-pathway; other site 455488003581 Putative proton exit pathway; other site 455488003582 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 455488003583 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 455488003584 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 455488003585 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 455488003586 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 455488003587 4Fe-4S binding domain; Region: Fer4_5; pfam12801 455488003588 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 455488003589 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488003590 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 455488003591 FixH; Region: FixH; pfam05751 455488003592 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 455488003593 YtkA-like; Region: YtkA; pfam13115 455488003594 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 455488003595 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 455488003596 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 455488003597 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 455488003598 metal-binding site [ion binding] 455488003599 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 455488003600 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 455488003601 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 455488003602 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 455488003603 substrate binding site [chemical binding]; other site 455488003604 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 455488003605 substrate binding site [chemical binding]; other site 455488003606 ligand binding site [chemical binding]; other site 455488003607 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 455488003608 nudix motif; other site 455488003609 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 455488003610 Aspartase; Region: Aspartase; cd01357 455488003611 aspartate ammonia-lyase; Provisional; Region: PRK13353 455488003612 active sites [active] 455488003613 tetramer interface [polypeptide binding]; other site 455488003614 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488003615 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 455488003616 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488003617 active site 455488003618 HIGH motif; other site 455488003619 nucleotide binding site [chemical binding]; other site 455488003620 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 455488003621 KMSKS motif; other site 455488003622 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 455488003623 GatB domain; Region: GatB_Yqey; cl17694 455488003624 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 455488003625 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 455488003626 active site 455488003627 HIGH motif; other site 455488003628 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 455488003629 active site 455488003630 KMSKS motif; other site 455488003631 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488003632 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488003633 active site 455488003634 active site 455488003635 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 455488003636 putative ligand binding pocket/active site [active] 455488003637 putative metal binding site [ion binding]; other site 455488003638 Response regulator receiver domain; Region: Response_reg; pfam00072 455488003639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488003640 active site 455488003641 phosphorylation site [posttranslational modification] 455488003642 intermolecular recognition site; other site 455488003643 dimerization interface [polypeptide binding]; other site 455488003644 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 455488003645 CAAX protease self-immunity; Region: Abi; pfam02517 455488003646 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 455488003647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488003648 Zn2+ binding site [ion binding]; other site 455488003649 Mg2+ binding site [ion binding]; other site 455488003650 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 455488003651 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 455488003652 putative dimer interface [polypeptide binding]; other site 455488003653 putative active site [active] 455488003654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488003655 nucleotide binding site [chemical binding]; other site 455488003656 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488003657 HSP70 interaction site [polypeptide binding]; other site 455488003658 Colicin V production protein; Region: Colicin_V; pfam02674 455488003659 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 455488003660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488003661 Walker A motif; other site 455488003662 ATP binding site [chemical binding]; other site 455488003663 Walker B motif; other site 455488003664 agmatinase; Region: agmatinase; TIGR01230 455488003665 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 455488003666 putative active site [active] 455488003667 Mn binding site [ion binding]; other site 455488003668 Predicted transcriptional regulator [Transcription]; Region: COG1959 455488003669 Transcriptional regulator; Region: Rrf2; pfam02082 455488003670 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 455488003671 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 455488003672 active site 455488003673 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 455488003674 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 455488003675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488003676 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 455488003677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488003678 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 455488003679 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488003680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488003681 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 455488003682 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 455488003683 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 455488003684 4Fe-4S binding domain; Region: Fer4; pfam00037 455488003685 4Fe-4S binding domain; Region: Fer4; pfam00037 455488003686 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 455488003687 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 455488003688 NADH dehydrogenase subunit D; Validated; Region: PRK06075 455488003689 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 455488003690 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 455488003691 NADH dehydrogenase subunit B; Provisional; Region: PRK14818 455488003692 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 455488003693 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 455488003694 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 455488003695 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 455488003696 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 455488003697 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 455488003698 NADH dehydrogenase subunit D; Validated; Region: PRK06075 455488003699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 455488003700 catalytic loop [active] 455488003701 iron binding site [ion binding]; other site 455488003702 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 455488003703 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488003704 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488003705 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 455488003706 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 455488003707 4Fe-4S binding domain; Region: Fer4; pfam00037 455488003708 muropeptide transporter; Validated; Region: ampG; cl17669 455488003709 muropeptide transporter; Reviewed; Region: ampG; PRK11902 455488003710 hypothetical protein; Provisional; Region: PRK08609 455488003711 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 455488003712 active site 455488003713 primer binding site [nucleotide binding]; other site 455488003714 NTP binding site [chemical binding]; other site 455488003715 metal binding triad [ion binding]; metal-binding site 455488003716 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 455488003717 active site 455488003718 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 455488003719 MPT binding site; other site 455488003720 trimer interface [polypeptide binding]; other site 455488003721 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 455488003722 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 455488003723 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 455488003724 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 455488003725 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 455488003726 Double zinc ribbon; Region: DZR; pfam12773 455488003727 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 455488003728 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488003729 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488003730 phosphopeptide binding site; other site 455488003731 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488003732 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488003733 phosphopeptide binding site; other site 455488003734 Domain of unknown function DUF77; Region: DUF77; pfam01910 455488003735 Double zinc ribbon; Region: DZR; pfam12773 455488003736 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 455488003737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488003738 phosphopeptide binding site; other site 455488003739 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 455488003740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488003741 Zn2+ binding site [ion binding]; other site 455488003742 Mg2+ binding site [ion binding]; other site 455488003743 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 455488003744 synthetase active site [active] 455488003745 NTP binding site [chemical binding]; other site 455488003746 metal binding site [ion binding]; metal-binding site 455488003747 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 455488003748 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 455488003749 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 455488003750 homotrimer interaction site [polypeptide binding]; other site 455488003751 putative active site [active] 455488003752 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 455488003753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488003754 FeS/SAM binding site; other site 455488003755 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 455488003756 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 455488003757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 455488003758 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 455488003759 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 455488003760 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 455488003761 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 455488003762 Stage II sporulation protein; Region: SpoIID; pfam08486 455488003763 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 455488003764 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 455488003765 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 455488003766 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 455488003767 Preprotein translocase subunit; Region: YajC; pfam02699 455488003768 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 455488003769 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 455488003770 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 455488003771 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 455488003772 Protein export membrane protein; Region: SecD_SecF; pfam02355 455488003773 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 455488003774 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 455488003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 455488003776 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488003777 active site 455488003778 phosphorylation site [posttranslational modification] 455488003779 intermolecular recognition site; other site 455488003780 dimerization interface [polypeptide binding]; other site 455488003781 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 455488003782 DHH family; Region: DHH; pfam01368 455488003783 DHHA1 domain; Region: DHHA1; pfam02272 455488003784 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 455488003785 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 455488003786 NADP binding site [chemical binding]; other site 455488003787 dimer interface [polypeptide binding]; other site 455488003788 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 455488003789 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 455488003790 dimer interface [polypeptide binding]; other site 455488003791 anticodon binding site; other site 455488003792 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 455488003793 homodimer interface [polypeptide binding]; other site 455488003794 motif 1; other site 455488003795 active site 455488003796 motif 2; other site 455488003797 GAD domain; Region: GAD; pfam02938 455488003798 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 455488003799 active site 455488003800 motif 3; other site 455488003801 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 455488003802 hydroxyglutarate oxidase; Provisional; Region: PRK11728 455488003803 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 455488003804 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 455488003805 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 455488003806 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 455488003807 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 455488003808 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 455488003809 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 455488003810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488003811 ATP binding site [chemical binding]; other site 455488003812 putative Mg++ binding site [ion binding]; other site 455488003813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488003814 nucleotide binding region [chemical binding]; other site 455488003815 ATP-binding site [chemical binding]; other site 455488003816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488003817 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488003818 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488003819 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488003820 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488003821 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488003822 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 455488003823 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 455488003824 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 455488003825 dimerization interface [polypeptide binding]; other site 455488003826 DPS ferroxidase diiron center [ion binding]; other site 455488003827 ion pore; other site 455488003828 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 455488003829 thiS-thiF/thiG interaction site; other site 455488003830 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 455488003831 ThiS interaction site; other site 455488003832 putative active site [active] 455488003833 tetramer interface [polypeptide binding]; other site 455488003834 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 455488003835 active site 455488003836 thiamine phosphate binding site [chemical binding]; other site 455488003837 pyrophosphate binding site [ion binding]; other site 455488003838 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488003839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488003840 S-adenosylmethionine binding site [chemical binding]; other site 455488003841 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 455488003842 active site 455488003843 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 455488003844 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 455488003845 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 455488003846 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 455488003847 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 455488003848 putative active site; other site 455488003849 catalytic residue [active] 455488003850 Protein of unknown function (DUF507); Region: DUF507; pfam04368 455488003851 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 455488003852 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 455488003853 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 455488003854 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 455488003855 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 455488003856 catalytic residue [active] 455488003857 Maf-like protein; Region: Maf; pfam02545 455488003858 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 455488003859 active site 455488003860 dimer interface [polypeptide binding]; other site 455488003861 SurA N-terminal domain; Region: SurA_N_3; cl07813 455488003862 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 455488003863 rod shape-determining protein MreC; Provisional; Region: PRK13922 455488003864 rod shape-determining protein MreC; Region: MreC; pfam04085 455488003865 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 455488003866 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 455488003867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 455488003868 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 455488003869 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488003870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488003871 catalytic residues [active] 455488003872 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 455488003873 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 455488003874 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 455488003875 tRNA; other site 455488003876 putative tRNA binding site [nucleotide binding]; other site 455488003877 putative NADP binding site [chemical binding]; other site 455488003878 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 455488003879 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 455488003880 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 455488003881 domain interfaces; other site 455488003882 active site 455488003883 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 455488003884 active site 455488003885 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 455488003886 Uncharacterized conserved protein [Function unknown]; Region: COG0585 455488003887 Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577 455488003888 active site 455488003889 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 455488003890 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 455488003891 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 455488003892 active site 455488003893 PHP-associated; Region: PHP_C; pfam13263 455488003894 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488003895 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488003896 active site 455488003897 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 455488003898 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 455488003899 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 455488003900 active site 455488003901 effector binding site; other site 455488003902 dimer interface [polypeptide binding]; other site 455488003903 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 455488003904 pyrroline-5-carboxylate reductase; Region: PLN02688 455488003905 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 455488003906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 455488003907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 455488003908 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 455488003909 catalytic loop [active] 455488003910 iron binding site [ion binding]; other site 455488003911 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 455488003912 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 455488003913 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 455488003914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488003915 NAD(P) binding site [chemical binding]; other site 455488003916 active site 455488003917 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 455488003918 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 455488003919 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 455488003920 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 455488003921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488003922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488003923 active site 455488003924 ATP binding site [chemical binding]; other site 455488003925 substrate binding site [chemical binding]; other site 455488003926 activation loop (A-loop); other site 455488003927 PEGA domain; Region: PEGA; pfam08308 455488003928 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 455488003929 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 455488003930 DNA binding residues [nucleotide binding] 455488003931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488003932 DNA binding residues [nucleotide binding] 455488003933 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 455488003934 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 455488003935 purine monophosphate binding site [chemical binding]; other site 455488003936 dimer interface [polypeptide binding]; other site 455488003937 putative catalytic residues [active] 455488003938 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 455488003939 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 455488003940 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 455488003941 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 455488003942 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 455488003943 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 455488003944 AIR carboxylase; Region: AIRC; pfam00731 455488003945 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 455488003946 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 455488003947 Predicted permeases [General function prediction only]; Region: COG0795 455488003948 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 455488003949 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 455488003950 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 455488003951 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 455488003952 Walker A/P-loop; other site 455488003953 ATP binding site [chemical binding]; other site 455488003954 Q-loop/lid; other site 455488003955 ABC transporter signature motif; other site 455488003956 Walker B; other site 455488003957 D-loop; other site 455488003958 H-loop/switch region; other site 455488003959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 455488003960 putative homodimer interface [polypeptide binding]; other site 455488003961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488003962 active site 455488003963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488003964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488003965 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 455488003966 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 455488003967 DXD motif; other site 455488003968 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 455488003969 Bacterial sugar transferase; Region: Bac_transf; pfam02397 455488003970 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 455488003971 Uncharacterized conserved protein [Function unknown]; Region: COG4198 455488003972 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 455488003973 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 455488003974 dimer interface [polypeptide binding]; other site 455488003975 active site 455488003976 Schiff base residues; other site 455488003977 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 455488003978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488003979 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 455488003980 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 455488003981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488003982 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 455488003983 homodimer interface [polypeptide binding]; other site 455488003984 homotetramer interface [polypeptide binding]; other site 455488003985 active site pocket [active] 455488003986 cleavage site 455488003987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 455488003988 dimerization interface [polypeptide binding]; other site 455488003989 DNA binding residues [nucleotide binding] 455488003990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 455488003991 Integrase core domain; Region: rve; pfam00665 455488003992 transposase/IS protein; Provisional; Region: PRK09183 455488003993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488003994 Walker A motif; other site 455488003995 ATP binding site [chemical binding]; other site 455488003996 Walker B motif; other site 455488003997 arginine finger; other site 455488003998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 455488003999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004000 ATP binding site [chemical binding]; other site 455488004001 Mg2+ binding site [ion binding]; other site 455488004002 G-X-G motif; other site 455488004003 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004005 active site 455488004006 phosphorylation site [posttranslational modification] 455488004007 intermolecular recognition site; other site 455488004008 dimerization interface [polypeptide binding]; other site 455488004009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488004010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 455488004011 dimerization interface [polypeptide binding]; other site 455488004012 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 455488004013 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 455488004014 TPP-binding site [chemical binding]; other site 455488004015 tetramer interface [polypeptide binding]; other site 455488004016 heterodimer interface [polypeptide binding]; other site 455488004017 phosphorylation loop region [posttranslational modification] 455488004018 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 455488004019 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 455488004020 DNA binding residues [nucleotide binding] 455488004021 Methyltransferase domain; Region: Methyltransf_11; pfam08241 455488004022 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 455488004023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 455488004024 FeS/SAM binding site; other site 455488004025 oxidative damage protection protein; Provisional; Region: PRK05408 455488004026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488004027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488004028 non-specific DNA binding site [nucleotide binding]; other site 455488004029 salt bridge; other site 455488004030 sequence-specific DNA binding site [nucleotide binding]; other site 455488004031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 455488004032 phosphorylation site [posttranslational modification] 455488004033 intermolecular recognition site; other site 455488004034 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 455488004035 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 455488004036 dimer interface [polypeptide binding]; other site 455488004037 putative functional site; other site 455488004038 putative MPT binding site; other site 455488004039 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 455488004040 ribonuclease R; Region: RNase_R; TIGR02063 455488004041 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 455488004042 RNB domain; Region: RNB; pfam00773 455488004043 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 455488004044 RNA binding site [nucleotide binding]; other site 455488004045 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 455488004046 FOG: CBS domain [General function prediction only]; Region: COG0517 455488004047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 455488004048 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 455488004049 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 455488004050 Walker A/P-loop; other site 455488004051 ATP binding site [chemical binding]; other site 455488004052 Q-loop/lid; other site 455488004053 ABC transporter signature motif; other site 455488004054 Walker B; other site 455488004055 D-loop; other site 455488004056 H-loop/switch region; other site 455488004057 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 455488004058 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 455488004059 Walker A/P-loop; other site 455488004060 ATP binding site [chemical binding]; other site 455488004061 Q-loop/lid; other site 455488004062 ABC transporter signature motif; other site 455488004063 Walker B; other site 455488004064 D-loop; other site 455488004065 H-loop/switch region; other site 455488004066 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 455488004067 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 455488004068 TM-ABC transporter signature motif; other site 455488004069 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 455488004070 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 455488004071 TM-ABC transporter signature motif; other site 455488004072 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 455488004073 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 455488004074 MutS domain III; Region: MutS_III; pfam05192 455488004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488004076 Walker A/P-loop; other site 455488004077 ATP binding site [chemical binding]; other site 455488004078 Q-loop/lid; other site 455488004079 ABC transporter signature motif; other site 455488004080 Walker B; other site 455488004081 D-loop; other site 455488004082 H-loop/switch region; other site 455488004083 Smr domain; Region: Smr; pfam01713 455488004084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488004085 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488004086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 455488004087 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 455488004088 NodB motif; other site 455488004089 putative active site [active] 455488004090 putative catalytic site [active] 455488004091 putative Zn binding site [ion binding]; other site 455488004092 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 455488004093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 455488004094 DNA binding residues [nucleotide binding] 455488004095 Caspase domain; Region: Peptidase_C14; pfam00656 455488004096 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 455488004097 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 455488004098 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 455488004099 active site 455488004100 (T/H)XGH motif; other site 455488004101 Rossmann-like domain; Region: Rossmann-like; pfam10727 455488004102 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 455488004103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004104 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488004105 Walker A motif; other site 455488004106 ATP binding site [chemical binding]; other site 455488004107 Walker B motif; other site 455488004108 arginine finger; other site 455488004109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004110 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488004111 Walker A motif; other site 455488004112 ATP binding site [chemical binding]; other site 455488004113 Walker B motif; other site 455488004114 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 455488004115 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 455488004116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488004117 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488004118 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 455488004119 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 455488004120 iron-sulfur cluster [ion binding]; other site 455488004121 [2Fe-2S] cluster binding site [ion binding]; other site 455488004122 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 455488004123 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 455488004124 interchain domain interface [polypeptide binding]; other site 455488004125 intrachain domain interface; other site 455488004126 heme bL binding site [chemical binding]; other site 455488004127 heme bH binding site [chemical binding]; other site 455488004128 Qo binding site; other site 455488004129 intrachain domain interface; other site 455488004130 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 455488004131 Qo binding site; other site 455488004132 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 455488004133 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 455488004134 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 455488004135 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 455488004136 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 455488004137 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 455488004138 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488004139 Walker A/P-loop; other site 455488004140 ATP binding site [chemical binding]; other site 455488004141 Q-loop/lid; other site 455488004142 ABC transporter signature motif; other site 455488004143 Walker B; other site 455488004144 D-loop; other site 455488004145 H-loop/switch region; other site 455488004146 NosL; Region: NosL; cl01769 455488004147 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 455488004148 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 455488004149 active site 455488004150 nucleophile elbow; other site 455488004151 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488004152 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488004153 active site 455488004154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488004155 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488004156 TPR motif; other site 455488004157 binding surface 455488004158 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 455488004159 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 455488004160 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 455488004161 ring oligomerisation interface [polypeptide binding]; other site 455488004162 ATP/Mg binding site [chemical binding]; other site 455488004163 stacking interactions; other site 455488004164 hinge regions; other site 455488004165 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004167 active site 455488004168 phosphorylation site [posttranslational modification] 455488004169 intermolecular recognition site; other site 455488004170 dimerization interface [polypeptide binding]; other site 455488004171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488004172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488004173 metal binding site [ion binding]; metal-binding site 455488004174 active site 455488004175 I-site; other site 455488004176 CheW-like domain; Region: CheW; pfam01584 455488004177 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004179 active site 455488004180 phosphorylation site [posttranslational modification] 455488004181 intermolecular recognition site; other site 455488004182 dimerization interface [polypeptide binding]; other site 455488004183 valyl-tRNA synthetase; Provisional; Region: valS; PRK14900 455488004184 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 455488004185 HIGH motif; other site 455488004186 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 455488004187 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 455488004188 active site 455488004189 KMSKS motif; other site 455488004190 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 455488004191 tRNA binding surface [nucleotide binding]; other site 455488004192 anticodon binding site; other site 455488004193 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 455488004194 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 455488004195 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 455488004196 dimerization interface [polypeptide binding]; other site 455488004197 active site 455488004198 Biotin operon repressor [Transcription]; Region: BirA; COG1654 455488004199 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 455488004200 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 455488004201 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 455488004202 pantothenate kinase; Reviewed; Region: PRK13321 455488004203 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 455488004204 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 455488004205 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 455488004206 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 455488004207 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004209 active site 455488004210 phosphorylation site [posttranslational modification] 455488004211 intermolecular recognition site; other site 455488004212 dimerization interface [polypeptide binding]; other site 455488004213 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 455488004214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488004215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488004216 DNA binding residues [nucleotide binding] 455488004217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488004218 Radical SAM superfamily; Region: Radical_SAM; pfam04055 455488004219 FeS/SAM binding site; other site 455488004220 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 455488004221 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 455488004222 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 455488004223 putative RNA binding site [nucleotide binding]; other site 455488004224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488004225 CAAX protease self-immunity; Region: Abi; cl00558 455488004226 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 455488004227 Flavoprotein; Region: Flavoprotein; pfam02441 455488004228 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 455488004229 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 455488004230 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 455488004231 Fe-S cluster binding site [ion binding]; other site 455488004232 active site 455488004233 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 455488004234 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 455488004235 active site residues [active] 455488004236 dimer interface [polypeptide binding]; other site 455488004237 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 455488004238 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 455488004239 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 455488004240 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 455488004241 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 455488004242 catalytic nucleophile [active] 455488004243 putative acyltransferase; Provisional; Region: PRK05790 455488004244 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 455488004245 dimer interface [polypeptide binding]; other site 455488004246 active site 455488004247 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 455488004248 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 455488004249 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 455488004250 PilZ domain; Region: PilZ; cl01260 455488004251 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 455488004252 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 455488004253 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488004254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488004255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488004256 acyl-activating enzyme (AAE) consensus motif; other site 455488004257 acyl-activating enzyme (AAE) consensus motif; other site 455488004258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488004259 AMP binding site [chemical binding]; other site 455488004260 active site 455488004261 CoA binding site [chemical binding]; other site 455488004262 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 455488004263 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 455488004264 Cna protein B-type domain; Region: Cna_B_2; pfam13715 455488004265 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 455488004266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 455488004267 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 455488004268 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 455488004269 Peptidase family M48; Region: Peptidase_M48; pfam01435 455488004270 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 455488004271 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 455488004272 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 455488004273 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 455488004274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488004275 FeS/SAM binding site; other site 455488004276 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 455488004277 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 455488004278 trimer interface [polypeptide binding]; other site 455488004279 putative metal binding site [ion binding]; other site 455488004280 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 455488004281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488004282 ligand binding site [chemical binding]; other site 455488004283 flexible hinge region; other site 455488004284 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 455488004285 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 455488004286 PilZ domain; Region: PilZ; cl01260 455488004287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488004288 rod shape-determining protein MreB; Provisional; Region: PRK13930 455488004289 nucleotide binding site [chemical binding]; other site 455488004290 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 455488004291 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 455488004292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 455488004293 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 455488004294 active site 455488004295 GMP synthase; Reviewed; Region: guaA; PRK00074 455488004296 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 455488004297 AMP/PPi binding site [chemical binding]; other site 455488004298 candidate oxyanion hole; other site 455488004299 catalytic triad [active] 455488004300 potential glutamine specificity residues [chemical binding]; other site 455488004301 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 455488004302 ATP Binding subdomain [chemical binding]; other site 455488004303 Ligand Binding sites [chemical binding]; other site 455488004304 Dimerization subdomain; other site 455488004305 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 455488004306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 455488004307 TPR motif; other site 455488004308 binding surface 455488004309 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 455488004310 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 455488004311 acyl-activating enzyme (AAE) consensus motif; other site 455488004312 putative AMP binding site [chemical binding]; other site 455488004313 putative active site [active] 455488004314 putative CoA binding site [chemical binding]; other site 455488004315 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004317 active site 455488004318 phosphorylation site [posttranslational modification] 455488004319 intermolecular recognition site; other site 455488004320 dimerization interface [polypeptide binding]; other site 455488004321 SCP-2 sterol transfer family; Region: SCP2; pfam02036 455488004322 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 455488004323 CoA-transferase family III; Region: CoA_transf_3; pfam02515 455488004324 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 455488004325 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 455488004326 intersubunit interface [polypeptide binding]; other site 455488004327 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 455488004328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488004329 Walker A/P-loop; other site 455488004330 ATP binding site [chemical binding]; other site 455488004331 Q-loop/lid; other site 455488004332 ABC transporter signature motif; other site 455488004333 Walker B; other site 455488004334 D-loop; other site 455488004335 H-loop/switch region; other site 455488004336 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 455488004337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 455488004338 Protein of unknown function (DUF554); Region: DUF554; pfam04474 455488004339 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488004340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488004341 active site 455488004342 Methyltransferase domain; Region: Methyltransf_23; pfam13489 455488004343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488004344 S-adenosylmethionine binding site [chemical binding]; other site 455488004345 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 455488004346 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 455488004347 dimer interface [polypeptide binding]; other site 455488004348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488004349 catalytic residue [active] 455488004350 aspartate aminotransferase; Provisional; Region: PRK06836 455488004351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488004353 homodimer interface [polypeptide binding]; other site 455488004354 catalytic residue [active] 455488004355 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 455488004356 TPR repeat; Region: TPR_11; pfam13414 455488004357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488004358 binding surface 455488004359 TPR motif; other site 455488004360 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 455488004361 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 455488004362 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 455488004363 Moco binding site; other site 455488004364 metal coordination site [ion binding]; other site 455488004365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488004366 active site 455488004367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488004368 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 455488004369 lipoyl attachment site [posttranslational modification]; other site 455488004370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488004371 NAD(P) binding site [chemical binding]; other site 455488004372 active site 455488004373 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 455488004374 NAD(P) binding pocket [chemical binding]; other site 455488004375 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488004376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488004377 S-adenosylmethionine binding site [chemical binding]; other site 455488004378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004379 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 455488004380 molybdopterin cofactor binding site; other site 455488004381 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004382 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 455488004383 putative molybdopterin cofactor binding site; other site 455488004384 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 455488004385 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488004386 putative NAD(P) binding site [chemical binding]; other site 455488004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488004388 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 455488004389 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 455488004390 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 455488004391 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488004392 active site 455488004393 metal binding site [ion binding]; metal-binding site 455488004394 DNA binding site [nucleotide binding] 455488004395 Epoxide hydrolase N terminus; Region: EHN; pfam06441 455488004396 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 455488004397 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 455488004398 Beta-lactamase; Region: Beta-lactamase; pfam00144 455488004399 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 455488004400 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 455488004401 putative hydrophobic ligand binding site [chemical binding]; other site 455488004402 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 455488004403 elongation factor G; Reviewed; Region: PRK12740 455488004404 G1 box; other site 455488004405 putative GEF interaction site [polypeptide binding]; other site 455488004406 GTP/Mg2+ binding site [chemical binding]; other site 455488004407 Switch I region; other site 455488004408 G2 box; other site 455488004409 G3 box; other site 455488004410 Switch II region; other site 455488004411 G4 box; other site 455488004412 G5 box; other site 455488004413 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 455488004414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 455488004415 Elongation factor G C-terminus; Region: EFG_C; smart00838 455488004416 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488004417 Walker A motif; other site 455488004418 ATP binding site [chemical binding]; other site 455488004419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488004420 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 455488004421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488004422 Q-loop/lid; other site 455488004423 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 455488004424 SnoaL-like domain; Region: SnoaL_3; pfam13474 455488004425 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 455488004426 Moco binding site; other site 455488004427 metal coordination site [ion binding]; other site 455488004428 dimerization interface [polypeptide binding]; other site 455488004429 Cytochrome c; Region: Cytochrom_C; pfam00034 455488004430 Cytochrome c; Region: Cytochrom_C; cl11414 455488004431 Predicted secreted protein [Function unknown]; Region: COG5501 455488004432 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 455488004433 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 455488004434 DsrE/DsrF-like family; Region: DrsE; cl00672 455488004435 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 455488004436 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 455488004437 active site 455488004438 metal binding site [ion binding]; metal-binding site 455488004439 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 455488004440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488004441 Cytochrome c; Region: Cytochrom_C; pfam00034 455488004442 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 455488004443 Cu(I) binding site [ion binding]; other site 455488004444 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 455488004445 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 455488004446 Cytochrome c; Region: Cytochrom_C; pfam00034 455488004447 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 455488004448 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 455488004449 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 455488004450 Subunit I/III interface [polypeptide binding]; other site 455488004451 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 455488004452 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 455488004453 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 455488004454 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 455488004455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488004456 S-adenosylmethionine binding site [chemical binding]; other site 455488004457 Cupin; Region: Cupin_6; pfam12852 455488004458 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 455488004459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488004460 OsmC-like protein; Region: OsmC; pfam02566 455488004461 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 455488004462 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 455488004463 tetramer interface [polypeptide binding]; other site 455488004464 active site 455488004465 Mg2+/Mn2+ binding site [ion binding]; other site 455488004466 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 455488004467 nucleotide binding site [chemical binding]; other site 455488004468 putative NEF/HSP70 interaction site [polypeptide binding]; other site 455488004469 SBD interface [polypeptide binding]; other site 455488004470 4Fe-4S binding domain; Region: Fer4; pfam00037 455488004471 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 455488004472 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 455488004473 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 455488004474 Predicted integral membrane protein [Function unknown]; Region: COG0392 455488004475 Uncharacterized conserved protein [Function unknown]; Region: COG2898 455488004476 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 455488004477 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 455488004478 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488004479 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488004480 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 455488004481 TAP-like protein; Region: Abhydrolase_4; pfam08386 455488004482 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488004483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488004484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488004485 DNA binding residues [nucleotide binding] 455488004486 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 455488004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 455488004488 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 455488004489 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 455488004490 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 455488004491 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 455488004492 tetrameric interface [polypeptide binding]; other site 455488004493 NAD binding site [chemical binding]; other site 455488004494 catalytic residues [active] 455488004495 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 455488004496 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 455488004497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488004498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488004499 dimerization interface [polypeptide binding]; other site 455488004500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004501 dimer interface [polypeptide binding]; other site 455488004502 phosphorylation site [posttranslational modification] 455488004503 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 455488004504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004505 ATP binding site [chemical binding]; other site 455488004506 Mg2+ binding site [ion binding]; other site 455488004507 G-X-G motif; other site 455488004508 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488004509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004510 active site 455488004511 phosphorylation site [posttranslational modification] 455488004512 intermolecular recognition site; other site 455488004513 dimerization interface [polypeptide binding]; other site 455488004514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004515 Walker A motif; other site 455488004516 ATP binding site [chemical binding]; other site 455488004517 Walker B motif; other site 455488004518 arginine finger; other site 455488004519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488004520 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 455488004521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488004522 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488004523 multidrug efflux protein; Reviewed; Region: PRK09579 455488004524 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 455488004525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 455488004526 DNA-binding site [nucleotide binding]; DNA binding site 455488004527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488004528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488004529 homodimer interface [polypeptide binding]; other site 455488004530 catalytic residue [active] 455488004531 Transcriptional activator [Transcription]; Region: ChrR; COG3806 455488004532 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488004533 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 455488004534 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 455488004535 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488004536 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488004537 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488004538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488004539 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 455488004540 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 455488004541 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 455488004542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488004543 S-adenosylmethionine binding site [chemical binding]; other site 455488004544 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 455488004545 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 455488004546 malate dehydrogenase; Reviewed; Region: PRK06223 455488004547 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 455488004548 NAD(P) binding site [chemical binding]; other site 455488004549 dimer interface [polypeptide binding]; other site 455488004550 tetramer (dimer of dimers) interface [polypeptide binding]; other site 455488004551 substrate binding site [chemical binding]; other site 455488004552 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 455488004553 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 455488004554 tetramer interface [polypeptide binding]; other site 455488004555 active site 455488004556 Mg2+/Mn2+ binding site [ion binding]; other site 455488004557 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 455488004558 5'-3' exonuclease; Region: 53EXOc; smart00475 455488004559 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 455488004560 active site 455488004561 metal binding site 1 [ion binding]; metal-binding site 455488004562 putative 5' ssDNA interaction site; other site 455488004563 metal binding site 3; metal-binding site 455488004564 metal binding site 2 [ion binding]; metal-binding site 455488004565 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 455488004566 putative DNA binding site [nucleotide binding]; other site 455488004567 putative metal binding site [ion binding]; other site 455488004568 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 455488004569 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 455488004570 Nitrogen regulatory protein P-II; Region: P-II; smart00938 455488004571 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 455488004572 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 455488004573 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 455488004574 putative FMN binding site [chemical binding]; other site 455488004575 LysR family transcriptional regulator; Provisional; Region: PRK14997 455488004576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488004577 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 455488004578 putative effector binding pocket; other site 455488004579 dimerization interface [polypeptide binding]; other site 455488004580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488004581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488004582 putative substrate translocation pore; other site 455488004583 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 455488004584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488004585 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 455488004586 dimerization interface [polypeptide binding]; other site 455488004587 substrate binding pocket [chemical binding]; other site 455488004588 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 455488004589 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 455488004590 active site 1 [active] 455488004591 dimer interface [polypeptide binding]; other site 455488004592 hexamer interface [polypeptide binding]; other site 455488004593 active site 2 [active] 455488004594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488004595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488004596 dimerization interface [polypeptide binding]; other site 455488004597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004598 dimer interface [polypeptide binding]; other site 455488004599 phosphorylation site [posttranslational modification] 455488004600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004601 ATP binding site [chemical binding]; other site 455488004602 Mg2+ binding site [ion binding]; other site 455488004603 G-X-G motif; other site 455488004604 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004606 active site 455488004607 phosphorylation site [posttranslational modification] 455488004608 intermolecular recognition site; other site 455488004609 dimerization interface [polypeptide binding]; other site 455488004610 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 455488004611 putative glycosyltransferase, TIGR04348 family; Region: TIGR04348 455488004612 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488004613 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 455488004614 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 455488004615 mercuric reductase; Validated; Region: PRK06370 455488004616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488004617 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 455488004618 Pirin-related protein [General function prediction only]; Region: COG1741 455488004619 Pirin; Region: Pirin; pfam02678 455488004620 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 455488004621 EamA-like transporter family; Region: EamA; pfam00892 455488004622 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 455488004623 dimerization interface [polypeptide binding]; other site 455488004624 putative effector binding pocket; other site 455488004625 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488004626 catalytic residues [active] 455488004627 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488004628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488004629 putative active site [active] 455488004630 heme pocket [chemical binding]; other site 455488004631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004632 dimer interface [polypeptide binding]; other site 455488004633 phosphorylation site [posttranslational modification] 455488004634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004635 ATP binding site [chemical binding]; other site 455488004636 Mg2+ binding site [ion binding]; other site 455488004637 G-X-G motif; other site 455488004638 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004640 active site 455488004641 phosphorylation site [posttranslational modification] 455488004642 intermolecular recognition site; other site 455488004643 dimerization interface [polypeptide binding]; other site 455488004644 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 455488004645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488004646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488004647 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 455488004648 active site 455488004649 FOG: CBS domain [General function prediction only]; Region: COG0517 455488004650 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 455488004651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488004652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488004653 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 455488004654 putative dimerization interface [polypeptide binding]; other site 455488004655 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 455488004656 ATP binding site [chemical binding]; other site 455488004657 ResB-like family; Region: ResB; pfam05140 455488004658 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 455488004659 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 455488004660 Rubrerythrin [Energy production and conversion]; Region: COG1592 455488004661 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 455488004662 binuclear metal center [ion binding]; other site 455488004663 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 455488004664 iron binding site [ion binding]; other site 455488004665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488004666 PAS fold; Region: PAS_3; pfam08447 455488004667 putative active site [active] 455488004668 heme pocket [chemical binding]; other site 455488004669 PAS fold; Region: PAS_3; pfam08447 455488004670 GAF domain; Region: GAF_3; pfam13492 455488004671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488004672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004673 dimer interface [polypeptide binding]; other site 455488004674 phosphorylation site [posttranslational modification] 455488004675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004676 ATP binding site [chemical binding]; other site 455488004677 Mg2+ binding site [ion binding]; other site 455488004678 G-X-G motif; other site 455488004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004680 Response regulator receiver domain; Region: Response_reg; pfam00072 455488004681 active site 455488004682 phosphorylation site [posttranslational modification] 455488004683 intermolecular recognition site; other site 455488004684 dimerization interface [polypeptide binding]; other site 455488004685 SnoaL-like domain; Region: SnoaL_2; pfam12680 455488004686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488004687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488004688 DNA binding residues [nucleotide binding] 455488004689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 455488004690 active site 2 [active] 455488004691 active site 1 [active] 455488004692 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 455488004693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488004694 dimerization interface [polypeptide binding]; other site 455488004695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488004696 dimer interface [polypeptide binding]; other site 455488004697 putative CheW interface [polypeptide binding]; other site 455488004698 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 455488004699 Nitrogen fixation protein NifW; Region: NifW; cl03935 455488004700 hypothetical protein; Provisional; Region: PRK12378 455488004701 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 455488004702 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 455488004703 Walker A/P-loop; other site 455488004704 ATP binding site [chemical binding]; other site 455488004705 Q-loop/lid; other site 455488004706 ABC transporter signature motif; other site 455488004707 Walker B; other site 455488004708 D-loop; other site 455488004709 H-loop/switch region; other site 455488004710 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 455488004711 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 455488004712 TM-ABC transporter signature motif; other site 455488004713 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 455488004714 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 455488004715 Walker A/P-loop; other site 455488004716 ATP binding site [chemical binding]; other site 455488004717 Q-loop/lid; other site 455488004718 ABC transporter signature motif; other site 455488004719 Walker B; other site 455488004720 D-loop; other site 455488004721 H-loop/switch region; other site 455488004722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 455488004723 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 455488004724 TM-ABC transporter signature motif; other site 455488004725 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 455488004726 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 455488004727 putative ligand binding site [chemical binding]; other site 455488004728 PilZ domain; Region: PilZ; pfam07238 455488004729 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 455488004730 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 455488004731 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 455488004732 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 455488004733 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 455488004734 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 455488004735 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 455488004736 [4Fe-4S] binding site [ion binding]; other site 455488004737 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004738 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004739 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004740 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 455488004741 molybdopterin cofactor binding site; other site 455488004742 PAS domain S-box; Region: sensory_box; TIGR00229 455488004743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488004744 putative active site [active] 455488004745 heme pocket [chemical binding]; other site 455488004746 Hemerythrin-like domain; Region: Hr-like; cd12108 455488004747 Fe binding site [ion binding]; other site 455488004748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 455488004749 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488004750 putative acyl-acceptor binding pocket; other site 455488004751 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 455488004752 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 455488004753 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 455488004754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488004755 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488004756 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 455488004757 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 455488004758 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 455488004759 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 455488004760 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 455488004761 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 455488004762 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 455488004763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488004764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488004765 ABC transporter; Region: ABC_tran_2; pfam12848 455488004766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488004767 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 455488004768 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 455488004769 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 455488004770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488004771 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 455488004772 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488004773 tetrathionate reductase subunit A; Provisional; Region: PRK14991 455488004774 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004775 molybdopterin cofactor binding site; other site 455488004776 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488004777 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 455488004778 molybdopterin cofactor binding site; other site 455488004779 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 455488004780 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 455488004781 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004783 active site 455488004784 phosphorylation site [posttranslational modification] 455488004785 intermolecular recognition site; other site 455488004786 dimerization interface [polypeptide binding]; other site 455488004787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004788 Walker A motif; other site 455488004789 ATP binding site [chemical binding]; other site 455488004790 Walker B motif; other site 455488004791 arginine finger; other site 455488004792 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488004793 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 455488004794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 455488004795 substrate binding pocket [chemical binding]; other site 455488004796 membrane-bound complex binding site; other site 455488004797 hinge residues; other site 455488004798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004799 dimer interface [polypeptide binding]; other site 455488004800 phosphorylation site [posttranslational modification] 455488004801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004802 ATP binding site [chemical binding]; other site 455488004803 Mg2+ binding site [ion binding]; other site 455488004804 G-X-G motif; other site 455488004805 Transposase domain (DUF772); Region: DUF772; pfam05598 455488004806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488004807 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488004808 Transposase domain (DUF772); Region: DUF772; pfam05598 455488004809 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488004810 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488004811 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 455488004812 putative deacylase active site [active] 455488004813 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 455488004814 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 455488004815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488004816 catalytic residues [active] 455488004817 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 455488004818 Asparaginase; Region: Asparaginase; pfam00710 455488004819 active site 455488004820 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 455488004821 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 455488004822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488004823 NAD(P) binding site [chemical binding]; other site 455488004824 active site 455488004825 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 455488004826 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 455488004827 TM-ABC transporter signature motif; other site 455488004828 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 455488004829 TM-ABC transporter signature motif; other site 455488004830 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 455488004831 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 455488004832 putative ligand binding site [chemical binding]; other site 455488004833 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 455488004834 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 455488004835 Walker A/P-loop; other site 455488004836 ATP binding site [chemical binding]; other site 455488004837 Q-loop/lid; other site 455488004838 ABC transporter signature motif; other site 455488004839 Walker B; other site 455488004840 D-loop; other site 455488004841 H-loop/switch region; other site 455488004842 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 455488004843 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 455488004844 Walker A/P-loop; other site 455488004845 ATP binding site [chemical binding]; other site 455488004846 Q-loop/lid; other site 455488004847 ABC transporter signature motif; other site 455488004848 Walker B; other site 455488004849 D-loop; other site 455488004850 H-loop/switch region; other site 455488004851 Hemerythrin-like domain; Region: Hr-like; cd12108 455488004852 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 455488004853 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 455488004854 Hemerythrin-like domain; Region: Hr-like; cd12108 455488004855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004856 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488004857 Walker A motif; other site 455488004858 ATP binding site [chemical binding]; other site 455488004859 Walker B motif; other site 455488004860 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488004861 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 455488004862 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 455488004863 E3 interaction surface; other site 455488004864 lipoyl attachment site [posttranslational modification]; other site 455488004865 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 455488004866 E3 interaction surface; other site 455488004867 lipoyl attachment site [posttranslational modification]; other site 455488004868 e3 binding domain; Region: E3_binding; pfam02817 455488004869 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 455488004870 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 455488004871 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 455488004872 dimer interface [polypeptide binding]; other site 455488004873 TPP-binding site [chemical binding]; other site 455488004874 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 455488004875 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 455488004876 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 455488004877 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 455488004878 Kelch motif; Region: Kelch_6; pfam13964 455488004879 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488004880 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488004881 active site 455488004882 ATP binding site [chemical binding]; other site 455488004883 substrate binding site [chemical binding]; other site 455488004884 activation loop (A-loop); other site 455488004885 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 455488004886 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488004887 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 455488004888 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488004889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488004890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488004891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488004892 active site 455488004893 catalytic tetrad [active] 455488004894 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 455488004895 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 455488004896 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488004897 active site 455488004898 metal binding site [ion binding]; metal-binding site 455488004899 Putative exonuclease, RdgC; Region: RdgC; cl01122 455488004900 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 455488004901 G1 box; other site 455488004902 GTP/Mg2+ binding site [chemical binding]; other site 455488004903 G2 box; other site 455488004904 Switch I region; other site 455488004905 G3 box; other site 455488004906 Switch II region; other site 455488004907 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 455488004908 G4 box; other site 455488004909 G5 box; other site 455488004910 TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666 455488004911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488004912 Coenzyme A binding pocket [chemical binding]; other site 455488004913 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 455488004914 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 455488004915 G1 box; other site 455488004916 putative GEF interaction site [polypeptide binding]; other site 455488004917 GTP/Mg2+ binding site [chemical binding]; other site 455488004918 Switch I region; other site 455488004919 G2 box; other site 455488004920 G3 box; other site 455488004921 Switch II region; other site 455488004922 G4 box; other site 455488004923 G5 box; other site 455488004924 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 455488004925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488004926 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 455488004927 dimer interface [polypeptide binding]; other site 455488004928 active site 455488004929 metal binding site [ion binding]; metal-binding site 455488004930 glutathione binding site [chemical binding]; other site 455488004931 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 455488004932 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 455488004933 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 455488004934 hexamer interface [polypeptide binding]; other site 455488004935 ligand binding site [chemical binding]; other site 455488004936 putative active site [active] 455488004937 NAD(P) binding site [chemical binding]; other site 455488004938 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 455488004939 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 455488004940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488004941 S-adenosylmethionine binding site [chemical binding]; other site 455488004942 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 455488004943 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 455488004944 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 455488004945 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 455488004946 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 455488004947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 455488004948 substrate binding pocket [chemical binding]; other site 455488004949 membrane-bound complex binding site; other site 455488004950 hinge residues; other site 455488004951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488004952 ATP binding site [chemical binding]; other site 455488004953 Mg2+ binding site [ion binding]; other site 455488004954 G-X-G motif; other site 455488004955 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488004956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488004957 active site 455488004958 phosphorylation site [posttranslational modification] 455488004959 intermolecular recognition site; other site 455488004960 dimerization interface [polypeptide binding]; other site 455488004961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488004962 Walker A motif; other site 455488004963 ATP binding site [chemical binding]; other site 455488004964 Walker B motif; other site 455488004965 arginine finger; other site 455488004966 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488004967 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 455488004968 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 455488004969 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 455488004970 active site 455488004971 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 455488004972 L-aspartate oxidase; Provisional; Region: PRK06175 455488004973 Predicted oxidoreductase [General function prediction only]; Region: COG3573 455488004974 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 455488004975 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 455488004976 NAD(P) binding site [chemical binding]; other site 455488004977 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 455488004978 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 455488004979 substrate-cofactor binding pocket; other site 455488004980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488004981 catalytic residue [active] 455488004982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488004983 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 455488004984 ATP binding site [chemical binding]; other site 455488004985 putative Mg++ binding site [ion binding]; other site 455488004986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488004987 nucleotide binding region [chemical binding]; other site 455488004988 ATP-binding site [chemical binding]; other site 455488004989 DEAD/H associated; Region: DEAD_assoc; pfam08494 455488004990 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 455488004991 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 455488004992 DNA binding site [nucleotide binding] 455488004993 catalytic residue [active] 455488004994 H2TH interface [polypeptide binding]; other site 455488004995 putative catalytic residues [active] 455488004996 CHASE domain; Region: CHASE; pfam03924 455488004997 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488004998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488004999 dimer interface [polypeptide binding]; other site 455488005000 phosphorylation site [posttranslational modification] 455488005001 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 455488005002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005003 ATP binding site [chemical binding]; other site 455488005004 Mg2+ binding site [ion binding]; other site 455488005005 G-X-G motif; other site 455488005006 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 455488005007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488005008 molybdopterin cofactor binding site; other site 455488005009 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488005010 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488005011 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 455488005012 molybdopterin cofactor binding site; other site 455488005013 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 455488005014 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488005015 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488005016 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 455488005017 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 455488005018 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 455488005019 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 455488005020 active site 455488005021 ADP/pyrophosphate binding site [chemical binding]; other site 455488005022 dimerization interface [polypeptide binding]; other site 455488005023 allosteric effector site; other site 455488005024 fructose-1,6-bisphosphate binding site; other site 455488005025 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 455488005026 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488005027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488005028 catalytic residue [active] 455488005029 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 455488005030 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 455488005031 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 455488005032 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 455488005033 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 455488005034 metal binding site [ion binding]; metal-binding site 455488005035 dimer interface [polypeptide binding]; other site 455488005036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488005037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 455488005038 putative acyl-acceptor binding pocket; other site 455488005039 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 455488005040 RNA/DNA hybrid binding site [nucleotide binding]; other site 455488005041 active site 455488005042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488005043 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488005044 active site 455488005045 catalytic tetrad [active] 455488005046 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 455488005047 diiron binding motif [ion binding]; other site 455488005048 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 455488005049 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 455488005050 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 455488005051 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 455488005052 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 455488005053 active site 455488005054 catalytic residues [active] 455488005055 metal binding site [ion binding]; metal-binding site 455488005056 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 455488005057 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 455488005058 tartrate dehydrogenase; Region: TTC; TIGR02089 455488005059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 455488005060 fumarate hydratase; Provisional; Region: PRK15389 455488005061 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 455488005062 Fumarase C-terminus; Region: Fumerase_C; pfam05683 455488005063 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 455488005064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 455488005065 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 455488005066 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 455488005067 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 455488005068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488005069 Walker A/P-loop; other site 455488005070 ATP binding site [chemical binding]; other site 455488005071 Q-loop/lid; other site 455488005072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488005073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488005074 elongation factor G; Reviewed; Region: PRK12739 455488005075 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 455488005076 G1 box; other site 455488005077 GTP/Mg2+ binding site [chemical binding]; other site 455488005078 G2 box; other site 455488005079 Switch I region; other site 455488005080 G3 box; other site 455488005081 Switch II region; other site 455488005082 G4 box; other site 455488005083 G5 box; other site 455488005084 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 455488005085 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 455488005086 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 455488005087 DTW domain; Region: DTW; cl01221 455488005088 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 455488005089 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 455488005090 putative active site [active] 455488005091 catalytic site [active] 455488005092 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 455488005093 putative active site [active] 455488005094 catalytic site [active] 455488005095 oligoendopeptidase F; Region: pepF; TIGR00181 455488005096 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 455488005097 active site 455488005098 Zn binding site [ion binding]; other site 455488005099 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 455488005100 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 455488005101 ATP-grasp domain; Region: ATP-grasp; pfam02222 455488005102 HEAT repeats; Region: HEAT_2; pfam13646 455488005103 IPT/TIG domain; Region: TIG; pfam01833 455488005104 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488005105 active site 455488005106 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 455488005107 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 455488005108 metal ion-dependent adhesion site (MIDAS); other site 455488005109 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 455488005110 dimer interface [polypeptide binding]; other site 455488005111 substrate binding site [chemical binding]; other site 455488005112 ATP binding site [chemical binding]; other site 455488005113 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 455488005114 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 455488005115 active site 455488005116 catalytic site [active] 455488005117 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 455488005118 MarC family integral membrane protein; Region: MarC; cl00919 455488005119 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 455488005120 active site 455488005121 catalytic triad [active] 455488005122 oxyanion hole [active] 455488005123 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 455488005124 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488005125 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488005126 Walker A/P-loop; other site 455488005127 ATP binding site [chemical binding]; other site 455488005128 Q-loop/lid; other site 455488005129 ABC transporter signature motif; other site 455488005130 Walker B; other site 455488005131 D-loop; other site 455488005132 H-loop/switch region; other site 455488005133 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488005134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488005135 FtsX-like permease family; Region: FtsX; pfam02687 455488005136 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 455488005137 HDOD domain; Region: HDOD; pfam08668 455488005138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 455488005139 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 455488005140 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 455488005141 Bacterial Ig-like domain; Region: Big_5; pfam13205 455488005142 MG2 domain; Region: A2M_N; pfam01835 455488005143 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 455488005144 Alpha-2-macroglobulin family; Region: A2M; pfam00207 455488005145 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 455488005146 surface patch; other site 455488005147 thioester region; other site 455488005148 specificity defining residues; other site 455488005149 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 455488005150 Transglycosylase; Region: Transgly; pfam00912 455488005151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 455488005152 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 455488005153 Protein of unknown function (DUF3115); Region: DUF3115; pfam11312 455488005154 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 455488005155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488005156 S-adenosylmethionine binding site [chemical binding]; other site 455488005157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488005158 binding surface 455488005159 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488005160 TPR motif; other site 455488005161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488005162 TPR motif; other site 455488005163 binding surface 455488005164 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 455488005165 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 455488005166 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488005167 DXD motif; other site 455488005168 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 455488005169 phosphoglucomutase; Validated; Region: PRK07564 455488005170 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 455488005171 active site 455488005172 substrate binding site [chemical binding]; other site 455488005173 metal binding site [ion binding]; metal-binding site 455488005174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488005175 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488005176 active site 455488005177 catalytic tetrad [active] 455488005178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488005179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488005180 NAD(P) binding site [chemical binding]; other site 455488005181 active site 455488005182 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 455488005183 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 455488005184 active site 455488005185 Zn binding site [ion binding]; other site 455488005186 CsbD-like; Region: CsbD; pfam05532 455488005187 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 455488005188 Protein export membrane protein; Region: SecD_SecF; cl14618 455488005189 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488005190 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488005191 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488005192 Outer membrane efflux protein; Region: OEP; pfam02321 455488005193 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 455488005194 GSH binding site [chemical binding]; other site 455488005195 catalytic residues [active] 455488005196 Peptidase family M48; Region: Peptidase_M48; cl12018 455488005197 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 455488005198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488005199 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 455488005200 putative dimerization interface [polypeptide binding]; other site 455488005201 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 455488005202 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 455488005203 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 455488005204 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 455488005205 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 455488005206 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 455488005207 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 455488005208 putative active site [active] 455488005209 putative substrate binding site [chemical binding]; other site 455488005210 putative cosubstrate binding site; other site 455488005211 catalytic site [active] 455488005212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488005213 dimerization interface [polypeptide binding]; other site 455488005214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488005215 dimer interface [polypeptide binding]; other site 455488005216 phosphorylation site [posttranslational modification] 455488005217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005218 ATP binding site [chemical binding]; other site 455488005219 Mg2+ binding site [ion binding]; other site 455488005220 G-X-G motif; other site 455488005221 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 455488005222 active site 455488005223 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488005224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005225 active site 455488005226 phosphorylation site [posttranslational modification] 455488005227 intermolecular recognition site; other site 455488005228 dimerization interface [polypeptide binding]; other site 455488005229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488005230 Walker A motif; other site 455488005231 ATP binding site [chemical binding]; other site 455488005232 Walker B motif; other site 455488005233 arginine finger; other site 455488005234 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488005235 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 455488005236 4Fe-4S binding domain; Region: Fer4; pfam00037 455488005237 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488005238 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 455488005239 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 455488005240 lipoyl attachment site [posttranslational modification]; other site 455488005241 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 455488005242 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 455488005243 lipoyl attachment site [posttranslational modification]; other site 455488005244 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 455488005245 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488005246 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488005247 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488005248 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 455488005249 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 455488005250 Peptidase family M48; Region: Peptidase_M48; cl12018 455488005251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488005252 dimerization interface [polypeptide binding]; other site 455488005253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 455488005254 Histidine kinase; Region: HisKA_3; pfam07730 455488005255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005256 ATP binding site [chemical binding]; other site 455488005257 Mg2+ binding site [ion binding]; other site 455488005258 G-X-G motif; other site 455488005259 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488005260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005261 active site 455488005262 phosphorylation site [posttranslational modification] 455488005263 intermolecular recognition site; other site 455488005264 dimerization interface [polypeptide binding]; other site 455488005265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488005266 DNA binding residues [nucleotide binding] 455488005267 dimerization interface [polypeptide binding]; other site 455488005268 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 455488005269 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 455488005270 NAD(P) binding pocket [chemical binding]; other site 455488005271 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 455488005272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488005273 dimerization interface [polypeptide binding]; other site 455488005274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488005275 dimer interface [polypeptide binding]; other site 455488005276 phosphorylation site [posttranslational modification] 455488005277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005278 ATP binding site [chemical binding]; other site 455488005279 Mg2+ binding site [ion binding]; other site 455488005280 G-X-G motif; other site 455488005281 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 455488005282 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 455488005283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488005284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488005285 DNA binding residues [nucleotide binding] 455488005286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488005287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488005288 dimer interface [polypeptide binding]; other site 455488005289 phosphorylation site [posttranslational modification] 455488005290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005291 Response regulator receiver domain; Region: Response_reg; pfam00072 455488005292 active site 455488005293 phosphorylation site [posttranslational modification] 455488005294 intermolecular recognition site; other site 455488005295 dimerization interface [polypeptide binding]; other site 455488005296 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 455488005297 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 455488005298 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 455488005299 G1 box; other site 455488005300 putative GEF interaction site [polypeptide binding]; other site 455488005301 GTP/Mg2+ binding site [chemical binding]; other site 455488005302 Switch I region; other site 455488005303 G2 box; other site 455488005304 G3 box; other site 455488005305 Switch II region; other site 455488005306 G4 box; other site 455488005307 G5 box; other site 455488005308 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 455488005309 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 455488005310 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488005311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 455488005312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488005313 active site 455488005314 metal binding site [ion binding]; metal-binding site 455488005315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488005316 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 455488005317 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 455488005318 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 455488005319 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 455488005320 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 455488005321 active site 455488005322 dimer interface [polypeptide binding]; other site 455488005323 motif 1; other site 455488005324 motif 2; other site 455488005325 motif 3; other site 455488005326 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 455488005327 anticodon binding site; other site 455488005328 2-isopropylmalate synthase; Validated; Region: PRK00915 455488005329 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 455488005330 active site 455488005331 catalytic residues [active] 455488005332 metal binding site [ion binding]; metal-binding site 455488005333 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 455488005334 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 455488005335 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 455488005336 substrate binding site [chemical binding]; other site 455488005337 ligand binding site [chemical binding]; other site 455488005338 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 455488005339 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 455488005340 substrate binding site [chemical binding]; other site 455488005341 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 455488005342 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 455488005343 PYR/PP interface [polypeptide binding]; other site 455488005344 dimer interface [polypeptide binding]; other site 455488005345 TPP binding site [chemical binding]; other site 455488005346 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 455488005347 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 455488005348 TPP-binding site [chemical binding]; other site 455488005349 dimer interface [polypeptide binding]; other site 455488005350 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 455488005351 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 455488005352 putative valine binding site [chemical binding]; other site 455488005353 dimer interface [polypeptide binding]; other site 455488005354 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 455488005355 ketol-acid reductoisomerase; Provisional; Region: PRK05479 455488005356 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 455488005357 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 455488005358 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 455488005359 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 455488005360 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 455488005361 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 455488005362 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 455488005363 23S rRNA binding site [nucleotide binding]; other site 455488005364 L21 binding site [polypeptide binding]; other site 455488005365 L13 binding site [polypeptide binding]; other site 455488005366 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 455488005367 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 455488005368 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 455488005369 dimer interface [polypeptide binding]; other site 455488005370 motif 1; other site 455488005371 active site 455488005372 motif 2; other site 455488005373 motif 3; other site 455488005374 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 455488005375 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 455488005376 putative tRNA-binding site [nucleotide binding]; other site 455488005377 B3/4 domain; Region: B3_4; pfam03483 455488005378 tRNA synthetase B5 domain; Region: B5; smart00874 455488005379 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 455488005380 dimer interface [polypeptide binding]; other site 455488005381 motif 1; other site 455488005382 motif 3; other site 455488005383 motif 2; other site 455488005384 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 455488005385 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 455488005386 IHF dimer interface [polypeptide binding]; other site 455488005387 IHF - DNA interface [nucleotide binding]; other site 455488005388 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488005389 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 455488005390 iron-sulfur cluster [ion binding]; other site 455488005391 [2Fe-2S] cluster binding site [ion binding]; other site 455488005392 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 455488005393 active site 455488005394 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 455488005395 active site 455488005396 classical (c) SDRs; Region: SDR_c; cd05233 455488005397 NAD(P) binding site [chemical binding]; other site 455488005398 active site 455488005399 FAD binding domain; Region: FAD_binding_4; pfam01565 455488005400 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 455488005401 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 455488005402 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 455488005403 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 455488005404 dimer interface [polypeptide binding]; other site 455488005405 PYR/PP interface [polypeptide binding]; other site 455488005406 TPP binding site [chemical binding]; other site 455488005407 substrate binding site [chemical binding]; other site 455488005408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 455488005409 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 455488005410 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 455488005411 TPP-binding site [chemical binding]; other site 455488005412 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 455488005413 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 455488005414 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 455488005415 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 455488005416 dimer interface [polypeptide binding]; other site 455488005417 PYR/PP interface [polypeptide binding]; other site 455488005418 TPP binding site [chemical binding]; other site 455488005419 substrate binding site [chemical binding]; other site 455488005420 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 455488005421 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 455488005422 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 455488005423 TPP-binding site [chemical binding]; other site 455488005424 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 455488005425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 455488005426 binding surface 455488005427 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 455488005428 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 455488005429 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488005430 NAD binding site [chemical binding]; other site 455488005431 putative substrate binding site 2 [chemical binding]; other site 455488005432 putative substrate binding site 1 [chemical binding]; other site 455488005433 active site 455488005434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488005435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488005436 NAD(P) binding site [chemical binding]; other site 455488005437 active site 455488005438 Transglycosylase; Region: Transgly; pfam00912 455488005439 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 455488005440 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 455488005441 endonuclease III; Region: ENDO3c; smart00478 455488005442 minor groove reading motif; other site 455488005443 helix-hairpin-helix signature motif; other site 455488005444 substrate binding pocket [chemical binding]; other site 455488005445 active site 455488005446 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 455488005447 S17 interaction site [polypeptide binding]; other site 455488005448 S8 interaction site; other site 455488005449 16S rRNA interaction site [nucleotide binding]; other site 455488005450 streptomycin interaction site [chemical binding]; other site 455488005451 23S rRNA interaction site [nucleotide binding]; other site 455488005452 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 455488005453 30S ribosomal protein S7; Validated; Region: PRK05302 455488005454 elongation factor G; Reviewed; Region: PRK00007 455488005455 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 455488005456 G1 box; other site 455488005457 putative GEF interaction site [polypeptide binding]; other site 455488005458 GTP/Mg2+ binding site [chemical binding]; other site 455488005459 Switch I region; other site 455488005460 G2 box; other site 455488005461 G3 box; other site 455488005462 Switch II region; other site 455488005463 G4 box; other site 455488005464 G5 box; other site 455488005465 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 455488005466 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 455488005467 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 455488005468 elongation factor Tu; Reviewed; Region: PRK00049 455488005469 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 455488005470 G1 box; other site 455488005471 GEF interaction site [polypeptide binding]; other site 455488005472 GTP/Mg2+ binding site [chemical binding]; other site 455488005473 Switch I region; other site 455488005474 G2 box; other site 455488005475 G3 box; other site 455488005476 Switch II region; other site 455488005477 G4 box; other site 455488005478 G5 box; other site 455488005479 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 455488005480 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 455488005481 Antibiotic Binding Site [chemical binding]; other site 455488005482 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 455488005483 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 455488005484 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 455488005485 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 455488005486 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 455488005487 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 455488005488 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 455488005489 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 455488005490 protein-rRNA interface [nucleotide binding]; other site 455488005491 putative translocon binding site; other site 455488005492 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 455488005493 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 455488005494 G-X-X-G motif; other site 455488005495 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 455488005496 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 455488005497 23S rRNA interface [nucleotide binding]; other site 455488005498 5S rRNA interface [nucleotide binding]; other site 455488005499 putative antibiotic binding site [chemical binding]; other site 455488005500 L25 interface [polypeptide binding]; other site 455488005501 L27 interface [polypeptide binding]; other site 455488005502 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 455488005503 23S rRNA interface [nucleotide binding]; other site 455488005504 putative translocon interaction site; other site 455488005505 signal recognition particle (SRP54) interaction site; other site 455488005506 L23 interface [polypeptide binding]; other site 455488005507 trigger factor interaction site; other site 455488005508 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 455488005509 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 455488005510 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 455488005511 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 455488005512 RNA binding site [nucleotide binding]; other site 455488005513 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 455488005514 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 455488005515 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 455488005516 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 455488005517 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 455488005518 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 455488005519 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 455488005520 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 455488005521 5S rRNA interface [nucleotide binding]; other site 455488005522 L27 interface [polypeptide binding]; other site 455488005523 L5 interface [polypeptide binding]; other site 455488005524 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 455488005525 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 455488005526 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 455488005527 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 455488005528 23S rRNA binding site [nucleotide binding]; other site 455488005529 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 455488005530 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 455488005531 SecY translocase; Region: SecY; pfam00344 455488005532 adenylate kinase; Reviewed; Region: adk; PRK00279 455488005533 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 455488005534 AMP-binding site [chemical binding]; other site 455488005535 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 455488005536 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 455488005537 active site 455488005538 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 455488005539 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 455488005540 30S ribosomal protein S13; Region: bact_S13; TIGR03631 455488005541 30S ribosomal protein S11; Validated; Region: PRK05309 455488005542 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 455488005543 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 455488005544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488005545 RNA binding surface [nucleotide binding]; other site 455488005546 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 455488005547 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 455488005548 alphaNTD homodimer interface [polypeptide binding]; other site 455488005549 alphaNTD - beta interaction site [polypeptide binding]; other site 455488005550 alphaNTD - beta' interaction site [polypeptide binding]; other site 455488005551 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 455488005552 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 455488005553 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14525 455488005554 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 455488005555 KH domain; Region: KH_4; pfam13083 455488005556 G-X-X-G motif; other site 455488005557 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 455488005558 RimM N-terminal domain; Region: RimM; pfam01782 455488005559 PRC-barrel domain; Region: PRC; pfam05239 455488005560 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 455488005561 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 455488005562 hypothetical protein; Reviewed; Region: PRK12497 455488005563 Predicted methyltransferases [General function prediction only]; Region: COG0313 455488005564 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 455488005565 putative SAM binding site [chemical binding]; other site 455488005566 putative homodimer interface [polypeptide binding]; other site 455488005567 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488005568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005569 active site 455488005570 phosphorylation site [posttranslational modification] 455488005571 intermolecular recognition site; other site 455488005572 dimerization interface [polypeptide binding]; other site 455488005573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488005574 Walker A motif; other site 455488005575 ATP binding site [chemical binding]; other site 455488005576 Walker B motif; other site 455488005577 arginine finger; other site 455488005578 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488005579 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488005580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488005581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488005582 dimer interface [polypeptide binding]; other site 455488005583 phosphorylation site [posttranslational modification] 455488005584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005585 ATP binding site [chemical binding]; other site 455488005586 Mg2+ binding site [ion binding]; other site 455488005587 G-X-G motif; other site 455488005588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488005589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488005590 catalytic residue [active] 455488005591 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488005592 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488005593 active site 455488005594 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 455488005595 DnaJ domain; Region: DnaJ; pfam00226 455488005596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488005597 non-specific DNA binding site [nucleotide binding]; other site 455488005598 salt bridge; other site 455488005599 sequence-specific DNA binding site [nucleotide binding]; other site 455488005600 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488005601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488005602 RNA binding surface [nucleotide binding]; other site 455488005603 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488005604 active site 455488005605 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488005606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488005607 binding surface 455488005608 TPR motif; other site 455488005609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488005610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488005611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488005612 Walker A/P-loop; other site 455488005613 ATP binding site [chemical binding]; other site 455488005614 Q-loop/lid; other site 455488005615 ABC transporter signature motif; other site 455488005616 Walker B; other site 455488005617 D-loop; other site 455488005618 H-loop/switch region; other site 455488005619 arginine decarboxylase; Provisional; Region: PRK05354 455488005620 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 455488005621 active site 455488005622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 455488005623 catalytic residues [active] 455488005624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 455488005625 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 455488005626 Dodecin; Region: Dodecin; pfam07311 455488005627 methionine sulfoxide reductase A; Provisional; Region: PRK00058 455488005628 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 455488005629 heme-binding residues [chemical binding]; other site 455488005630 HYR domain; Region: HYR; pfam02494 455488005631 5' nucleotidase family; Region: 5_nucleotid; pfam05761 455488005632 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488005633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488005634 sequence-specific DNA binding site [nucleotide binding]; other site 455488005635 salt bridge; other site 455488005636 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488005637 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488005638 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488005639 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488005640 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488005641 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488005642 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488005643 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488005644 active site 455488005645 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 455488005646 Permease; Region: Permease; pfam02405 455488005647 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 455488005648 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 455488005649 Walker A/P-loop; other site 455488005650 ATP binding site [chemical binding]; other site 455488005651 Q-loop/lid; other site 455488005652 ABC transporter signature motif; other site 455488005653 Walker B; other site 455488005654 D-loop; other site 455488005655 H-loop/switch region; other site 455488005656 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 455488005657 mce related protein; Region: MCE; pfam02470 455488005658 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 455488005659 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488005660 catalytic residues [active] 455488005661 Domain of unknown function (DUF329); Region: DUF329; pfam03884 455488005662 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 455488005663 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 455488005664 dimerization interface [polypeptide binding]; other site 455488005665 ligand binding site [chemical binding]; other site 455488005666 NADP binding site [chemical binding]; other site 455488005667 catalytic site [active] 455488005668 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 455488005669 Beta propeller domain; Region: Beta_propel; pfam09826 455488005670 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 455488005671 active site 455488005672 oxyanion hole [active] 455488005673 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 455488005674 enoyl-CoA hydratase; Validated; Region: PRK08139 455488005675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488005676 substrate binding site [chemical binding]; other site 455488005677 oxyanion hole (OAH) forming residues; other site 455488005678 trimer interface [polypeptide binding]; other site 455488005679 GAF domain; Region: GAF; pfam01590 455488005680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488005681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488005682 dimer interface [polypeptide binding]; other site 455488005683 phosphorylation site [posttranslational modification] 455488005684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005685 ATP binding site [chemical binding]; other site 455488005686 Mg2+ binding site [ion binding]; other site 455488005687 G-X-G motif; other site 455488005688 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 455488005689 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 455488005690 B12 binding site [chemical binding]; other site 455488005691 cobalt ligand [ion binding]; other site 455488005692 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 455488005693 active site 455488005694 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 455488005695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488005696 FeS/SAM binding site; other site 455488005697 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 455488005698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005699 active site 455488005700 phosphorylation site [posttranslational modification] 455488005701 intermolecular recognition site; other site 455488005702 dimerization interface [polypeptide binding]; other site 455488005703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488005704 Zn2+ binding site [ion binding]; other site 455488005705 Mg2+ binding site [ion binding]; other site 455488005706 lipoyl synthase; Provisional; Region: PRK05481 455488005707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488005708 FeS/SAM binding site; other site 455488005709 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 455488005710 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 455488005711 TPP-binding site [chemical binding]; other site 455488005712 tetramer interface [polypeptide binding]; other site 455488005713 heterodimer interface [polypeptide binding]; other site 455488005714 phosphorylation loop region [posttranslational modification] 455488005715 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 455488005716 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 455488005717 alpha subunit interface [polypeptide binding]; other site 455488005718 TPP binding site [chemical binding]; other site 455488005719 heterodimer interface [polypeptide binding]; other site 455488005720 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 455488005721 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 455488005722 E3 interaction surface; other site 455488005723 lipoyl attachment site [posttranslational modification]; other site 455488005724 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 455488005725 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 455488005726 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 455488005727 active site 455488005728 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 455488005729 putative ATP binding site [chemical binding]; other site 455488005730 putative substrate interface [chemical binding]; other site 455488005731 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 455488005732 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 455488005733 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488005734 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 455488005735 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 455488005736 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 455488005737 nudix motif; other site 455488005738 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488005739 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488005740 active site 455488005741 ATP binding site [chemical binding]; other site 455488005742 substrate binding site [chemical binding]; other site 455488005743 activation loop (A-loop); other site 455488005744 OPT oligopeptide transporter protein; Region: OPT; cl14607 455488005745 OPT oligopeptide transporter protein; Region: OPT; cl14607 455488005746 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488005747 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488005748 phosphopeptide binding site; other site 455488005749 aspartate kinase; Validated; Region: PRK09181 455488005750 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 455488005751 nucleotide binding site [chemical binding]; other site 455488005752 substrate binding site [chemical binding]; other site 455488005753 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 455488005754 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 455488005755 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 455488005756 active sites [active] 455488005757 tetramer interface [polypeptide binding]; other site 455488005758 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 455488005759 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 455488005760 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 455488005761 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488005762 DXD motif; other site 455488005763 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 455488005764 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 455488005765 active site 455488005766 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 455488005767 Part of AAA domain; Region: AAA_19; pfam13245 455488005768 Family description; Region: UvrD_C_2; pfam13538 455488005769 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488005770 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 455488005771 nucleotide binding site [chemical binding]; other site 455488005772 SCP-2 sterol transfer family; Region: SCP2; cl01225 455488005773 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488005774 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 455488005775 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488005776 Helix-turn-helix domain; Region: HTH_17; pfam12728 455488005777 PAS fold; Region: PAS_4; pfam08448 455488005778 PAS domain; Region: PAS; smart00091 455488005779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488005780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488005781 dimer interface [polypeptide binding]; other site 455488005782 phosphorylation site [posttranslational modification] 455488005783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005784 ATP binding site [chemical binding]; other site 455488005785 Mg2+ binding site [ion binding]; other site 455488005786 G-X-G motif; other site 455488005787 pyrophosphatase PpaX; Provisional; Region: PRK13288 455488005788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488005789 active site 455488005790 motif I; other site 455488005791 motif II; other site 455488005792 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 455488005793 prephenate dehydratase; Provisional; Region: PRK11898 455488005794 Prephenate dehydratase; Region: PDT; pfam00800 455488005795 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 455488005796 putative L-Phe binding site [chemical binding]; other site 455488005797 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 455488005798 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 455488005799 active site 455488005800 nucleophile elbow; other site 455488005801 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 455488005802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488005803 Beta-Casp domain; Region: Beta-Casp; smart01027 455488005804 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 455488005805 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 455488005806 active site 455488005807 8-oxo-dGMP binding site [chemical binding]; other site 455488005808 nudix motif; other site 455488005809 metal binding site [ion binding]; metal-binding site 455488005810 FtsH Extracellular; Region: FtsH_ext; pfam06480 455488005811 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 455488005812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488005813 Walker A motif; other site 455488005814 ATP binding site [chemical binding]; other site 455488005815 Walker B motif; other site 455488005816 arginine finger; other site 455488005817 Peptidase family M41; Region: Peptidase_M41; pfam01434 455488005818 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 455488005819 GrpE; Region: GrpE; pfam01025 455488005820 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 455488005821 dimer interface [polypeptide binding]; other site 455488005822 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 455488005823 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 455488005824 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488005825 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488005826 protein binding site [polypeptide binding]; other site 455488005827 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 455488005828 protein binding site [polypeptide binding]; other site 455488005829 PilZ domain; Region: PilZ; cl01260 455488005830 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 455488005831 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 455488005832 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 455488005833 NAD(P) binding site [chemical binding]; other site 455488005834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 455488005835 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 455488005836 GIY-YIG motif/motif A; other site 455488005837 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 455488005838 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 455488005839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 455488005840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 455488005841 Histidine kinase; Region: HisKA_3; pfam07730 455488005842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005843 ATP binding site [chemical binding]; other site 455488005844 Mg2+ binding site [ion binding]; other site 455488005845 G-X-G motif; other site 455488005846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488005847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005848 active site 455488005849 phosphorylation site [posttranslational modification] 455488005850 intermolecular recognition site; other site 455488005851 dimerization interface [polypeptide binding]; other site 455488005852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488005853 DNA binding residues [nucleotide binding] 455488005854 dimerization interface [polypeptide binding]; other site 455488005855 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 455488005856 gating phenylalanine in ion channel; other site 455488005857 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 455488005858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 455488005859 substrate binding pocket [chemical binding]; other site 455488005860 membrane-bound complex binding site; other site 455488005861 hinge residues; other site 455488005862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488005863 ATP binding site [chemical binding]; other site 455488005864 Mg2+ binding site [ion binding]; other site 455488005865 G-X-G motif; other site 455488005866 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488005867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488005868 active site 455488005869 phosphorylation site [posttranslational modification] 455488005870 intermolecular recognition site; other site 455488005871 dimerization interface [polypeptide binding]; other site 455488005872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488005873 Walker A motif; other site 455488005874 ATP binding site [chemical binding]; other site 455488005875 Walker B motif; other site 455488005876 arginine finger; other site 455488005877 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488005878 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 455488005879 Aspartase; Region: Aspartase; cd01357 455488005880 active sites [active] 455488005881 tetramer interface [polypeptide binding]; other site 455488005882 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 455488005883 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 455488005884 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 455488005885 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 455488005886 trimer interface [polypeptide binding]; other site 455488005887 eyelet of channel; other site 455488005888 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 455488005889 heme-binding site [chemical binding]; other site 455488005890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488005891 Coenzyme A binding pocket [chemical binding]; other site 455488005892 RES domain; Region: RES; cl02411 455488005893 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 455488005894 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 455488005895 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 455488005896 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 455488005897 active site 455488005898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488005899 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488005900 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 455488005901 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488005902 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488005903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 455488005904 TAP-like protein; Region: Abhydrolase_4; pfam08386 455488005905 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 455488005906 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 455488005907 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 455488005908 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 455488005909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488005910 Walker A/P-loop; other site 455488005911 ATP binding site [chemical binding]; other site 455488005912 Q-loop/lid; other site 455488005913 ABC transporter signature motif; other site 455488005914 Walker B; other site 455488005915 D-loop; other site 455488005916 H-loop/switch region; other site 455488005917 TOBE-like domain; Region: TOBE_3; pfam12857 455488005918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488005919 dimer interface [polypeptide binding]; other site 455488005920 conserved gate region; other site 455488005921 putative PBP binding loops; other site 455488005922 ABC-ATPase subunit interface; other site 455488005923 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 455488005924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488005925 dimer interface [polypeptide binding]; other site 455488005926 conserved gate region; other site 455488005927 putative PBP binding loops; other site 455488005928 ABC-ATPase subunit interface; other site 455488005929 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 455488005930 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 455488005931 Active Sites [active] 455488005932 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 455488005933 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 455488005934 CysD dimerization site [polypeptide binding]; other site 455488005935 G1 box; other site 455488005936 putative GEF interaction site [polypeptide binding]; other site 455488005937 GTP/Mg2+ binding site [chemical binding]; other site 455488005938 Switch I region; other site 455488005939 G2 box; other site 455488005940 G3 box; other site 455488005941 Switch II region; other site 455488005942 G4 box; other site 455488005943 G5 box; other site 455488005944 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 455488005945 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 455488005946 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 455488005947 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 455488005948 Active Sites [active] 455488005949 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 455488005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488005951 S-adenosylmethionine binding site [chemical binding]; other site 455488005952 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 455488005953 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 455488005954 active site 455488005955 (T/H)XGH motif; other site 455488005956 aspartate aminotransferase; Provisional; Region: PRK05764 455488005957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488005958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488005959 homodimer interface [polypeptide binding]; other site 455488005960 catalytic residue [active] 455488005961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488005962 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 455488005963 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488005964 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 455488005965 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 455488005966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488005967 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488005968 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 455488005969 IMP binding site; other site 455488005970 dimer interface [polypeptide binding]; other site 455488005971 partial ornithine binding site; other site 455488005972 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 455488005973 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 455488005974 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 455488005975 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 455488005976 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 455488005977 ssDNA binding site; other site 455488005978 generic binding surface II; other site 455488005979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488005980 ATP binding site [chemical binding]; other site 455488005981 putative Mg++ binding site [ion binding]; other site 455488005982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488005983 nucleotide binding region [chemical binding]; other site 455488005984 ATP-binding site [chemical binding]; other site 455488005985 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135 455488005986 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 455488005987 aminotransferase; Validated; Region: PRK08175 455488005988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488005989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488005990 homodimer interface [polypeptide binding]; other site 455488005991 catalytic residue [active] 455488005992 threonine synthase; Region: PLN02569 455488005993 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 455488005994 homodimer interface [polypeptide binding]; other site 455488005995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488005996 catalytic residue [active] 455488005997 thymidylate kinase; Region: DTMP_kinase; TIGR00041 455488005998 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 455488005999 TMP-binding site; other site 455488006000 ATP-binding site [chemical binding]; other site 455488006001 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 455488006002 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 455488006003 putative MPT binding site; other site 455488006004 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 455488006005 Cytochrome c; Region: Cytochrom_C; pfam00034 455488006006 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 455488006007 Di-iron ligands [ion binding]; other site 455488006008 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488006009 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 455488006010 putative acyl-acceptor binding pocket; other site 455488006011 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 455488006012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006013 ATP binding site [chemical binding]; other site 455488006014 Mg2+ binding site [ion binding]; other site 455488006015 G-X-G motif; other site 455488006016 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 455488006017 ATP binding site [chemical binding]; other site 455488006018 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 455488006019 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 455488006020 phosphopeptide binding site; other site 455488006021 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 455488006022 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488006023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006024 Walker A motif; other site 455488006025 ATP binding site [chemical binding]; other site 455488006026 Walker B motif; other site 455488006027 arginine finger; other site 455488006028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488006029 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488006030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488006031 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488006032 active site 455488006033 ATP binding site [chemical binding]; other site 455488006034 substrate binding site [chemical binding]; other site 455488006035 activation loop (A-loop); other site 455488006036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488006037 active site 455488006038 Found in ATP-dependent protease La (LON); Region: LON; smart00464 455488006039 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 455488006040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006041 Walker A motif; other site 455488006042 ATP binding site [chemical binding]; other site 455488006043 Walker B motif; other site 455488006044 arginine finger; other site 455488006045 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 455488006046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488006047 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 455488006048 putative active site [active] 455488006049 putative metal binding site [ion binding]; other site 455488006050 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488006051 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 455488006052 LexA repressor; Validated; Region: PRK00215 455488006053 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 455488006054 Catalytic site [active] 455488006055 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 455488006056 ABC1 family; Region: ABC1; cl17513 455488006057 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 455488006058 active site 455488006059 ATP binding site [chemical binding]; other site 455488006060 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 455488006061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488006062 active site 455488006063 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 455488006064 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 455488006065 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 455488006066 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 455488006067 NodB motif; other site 455488006068 putative active site [active] 455488006069 putative catalytic site [active] 455488006070 putative Zn binding site [ion binding]; other site 455488006071 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 455488006072 MutS domain I; Region: MutS_I; pfam01624 455488006073 MutS domain II; Region: MutS_II; pfam05188 455488006074 MutS domain III; Region: MutS_III; pfam05192 455488006075 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 455488006076 Walker A/P-loop; other site 455488006077 ATP binding site [chemical binding]; other site 455488006078 Q-loop/lid; other site 455488006079 ABC transporter signature motif; other site 455488006080 Walker B; other site 455488006081 D-loop; other site 455488006082 H-loop/switch region; other site 455488006083 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 455488006084 heme-binding residues [chemical binding]; other site 455488006085 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 455488006086 heme-binding residues [chemical binding]; other site 455488006087 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 455488006088 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 455488006089 conserved cys residue [active] 455488006090 AMIN domain; Region: AMIN; pfam11741 455488006091 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 455488006092 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 455488006093 active site 455488006094 metal binding site [ion binding]; metal-binding site 455488006095 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 455488006096 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 455488006097 PII uridylyl-transferase; Provisional; Region: PRK05092 455488006098 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 455488006099 metal binding triad; other site 455488006100 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 455488006101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488006102 Zn2+ binding site [ion binding]; other site 455488006103 Mg2+ binding site [ion binding]; other site 455488006104 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 455488006105 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 455488006106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488006107 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 455488006108 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 455488006109 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488006110 active site 455488006111 DNA binding site [nucleotide binding] 455488006112 Int/Topo IB signature motif; other site 455488006113 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 455488006114 Peptidase family M50; Region: Peptidase_M50; pfam02163 455488006115 active site 455488006116 putative substrate binding region [chemical binding]; other site 455488006117 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 455488006118 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 455488006119 active site 455488006120 HIGH motif; other site 455488006121 dimer interface [polypeptide binding]; other site 455488006122 KMSKS motif; other site 455488006123 ScpA/B protein; Region: ScpA_ScpB; cl00598 455488006124 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 455488006125 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 455488006126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 455488006127 RNA binding surface [nucleotide binding]; other site 455488006128 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 455488006129 active site 455488006130 Secretin and TonB N terminus short domain; Region: STN; pfam07660 455488006131 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 455488006132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488006133 DNA binding residues [nucleotide binding] 455488006134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 455488006135 transmembrane helices; other site 455488006136 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 455488006137 RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399 455488006138 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 455488006139 putative active site [active] 455488006140 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 455488006141 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 455488006142 oligomer interface [polypeptide binding]; other site 455488006143 metal binding site [ion binding]; metal-binding site 455488006144 metal binding site [ion binding]; metal-binding site 455488006145 putative Cl binding site [ion binding]; other site 455488006146 aspartate ring; other site 455488006147 basic sphincter; other site 455488006148 hydrophobic gate; other site 455488006149 periplasmic entrance; other site 455488006150 Domain of unknown function DUF59; Region: DUF59; pfam01883 455488006151 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 455488006152 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 455488006153 Walker A motif; other site 455488006154 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 455488006155 active site 455488006156 catalytic residues [active] 455488006157 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 455488006158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488006159 PAS domain; Region: PAS_9; pfam13426 455488006160 putative active site [active] 455488006161 heme pocket [chemical binding]; other site 455488006162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488006163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488006164 dimer interface [polypeptide binding]; other site 455488006165 phosphorylation site [posttranslational modification] 455488006166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006167 ATP binding site [chemical binding]; other site 455488006168 Mg2+ binding site [ion binding]; other site 455488006169 G-X-G motif; other site 455488006170 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 455488006171 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 455488006172 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 455488006173 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 455488006174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488006175 substrate binding site [chemical binding]; other site 455488006176 oxyanion hole (OAH) forming residues; other site 455488006177 trimer interface [polypeptide binding]; other site 455488006178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488006179 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 455488006180 FAD binding site [chemical binding]; other site 455488006181 homotetramer interface [polypeptide binding]; other site 455488006182 substrate binding pocket [chemical binding]; other site 455488006183 catalytic base [active] 455488006184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488006185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488006186 active site 455488006187 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 455488006188 dimerization interface [polypeptide binding]; other site 455488006189 active site 455488006190 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 455488006191 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 455488006192 DNA binding residues [nucleotide binding] 455488006193 dimer interface [polypeptide binding]; other site 455488006194 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 455488006195 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 455488006196 active site 455488006197 8-oxo-dGMP binding site [chemical binding]; other site 455488006198 nudix motif; other site 455488006199 metal binding site [ion binding]; metal-binding site 455488006200 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 455488006201 PQQ-like domain; Region: PQQ_2; pfam13360 455488006202 Trp docking motif [polypeptide binding]; other site 455488006203 active site 455488006204 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 455488006205 GTP-binding protein Der; Reviewed; Region: PRK00093 455488006206 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 455488006207 G1 box; other site 455488006208 GTP/Mg2+ binding site [chemical binding]; other site 455488006209 Switch I region; other site 455488006210 G2 box; other site 455488006211 Switch II region; other site 455488006212 G3 box; other site 455488006213 G4 box; other site 455488006214 G5 box; other site 455488006215 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 455488006216 G1 box; other site 455488006217 GTP/Mg2+ binding site [chemical binding]; other site 455488006218 Switch I region; other site 455488006219 G2 box; other site 455488006220 G3 box; other site 455488006221 Switch II region; other site 455488006222 G4 box; other site 455488006223 G5 box; other site 455488006224 GTPase Era; Reviewed; Region: era; PRK00089 455488006225 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 455488006226 G1 box; other site 455488006227 GTP/Mg2+ binding site [chemical binding]; other site 455488006228 Switch I region; other site 455488006229 G2 box; other site 455488006230 Switch II region; other site 455488006231 G3 box; other site 455488006232 G4 box; other site 455488006233 G5 box; other site 455488006234 KH domain; Region: KH_2; pfam07650 455488006235 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 455488006236 active site 455488006237 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 455488006238 active site 455488006239 ribonuclease III; Reviewed; Region: rnc; PRK00102 455488006240 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 455488006241 dimerization interface [polypeptide binding]; other site 455488006242 active site 455488006243 metal binding site [ion binding]; metal-binding site 455488006244 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 455488006245 dsRNA binding site [nucleotide binding]; other site 455488006246 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 455488006247 Walker A; other site 455488006248 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 455488006249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488006250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488006251 active site 455488006252 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 455488006253 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 455488006254 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 455488006255 enoyl-CoA hydratase; Provisional; Region: PRK06688 455488006256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488006257 substrate binding site [chemical binding]; other site 455488006258 oxyanion hole (OAH) forming residues; other site 455488006259 trimer interface [polypeptide binding]; other site 455488006260 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 455488006261 active site 455488006262 catalytic residues [active] 455488006263 metal binding site [ion binding]; metal-binding site 455488006264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 455488006265 active site residue [active] 455488006266 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 455488006267 ThiC family; Region: ThiC; pfam01964 455488006268 enolase; Provisional; Region: eno; PRK00077 455488006269 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 455488006270 dimer interface [polypeptide binding]; other site 455488006271 metal binding site [ion binding]; metal-binding site 455488006272 substrate binding pocket [chemical binding]; other site 455488006273 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 455488006274 hydrophobic ligand binding site; other site 455488006275 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 455488006276 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 455488006277 putative active site [active] 455488006278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488006279 active site 455488006280 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 455488006281 homoserine dehydrogenase; Provisional; Region: PRK06349 455488006282 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 455488006283 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 455488006284 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 455488006285 HEAT repeats; Region: HEAT_2; pfam13646 455488006286 Restriction endonuclease; Region: Mrr_cat; pfam04471 455488006287 PQQ-like domain; Region: PQQ_2; pfam13360 455488006288 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 455488006289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488006290 active site 455488006291 metal binding site [ion binding]; metal-binding site 455488006292 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 455488006293 substrate binding site [chemical binding]; other site 455488006294 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 455488006295 ATP binding site [chemical binding]; other site 455488006296 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 455488006297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488006298 FeS/SAM binding site; other site 455488006299 Domain of unknown function DUF21; Region: DUF21; pfam01595 455488006300 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 455488006301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 455488006302 Transporter associated domain; Region: CorC_HlyC; smart01091 455488006303 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 455488006304 active site 455488006305 multimer interface [polypeptide binding]; other site 455488006306 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 455488006307 CoA binding domain; Region: CoA_binding; pfam02629 455488006308 CoA-ligase; Region: Ligase_CoA; pfam00549 455488006309 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 455488006310 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 455488006311 CoA-ligase; Region: Ligase_CoA; pfam00549 455488006312 malate dehydrogenase; Reviewed; Region: PRK06223 455488006313 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 455488006314 NAD(P) binding site [chemical binding]; other site 455488006315 dimer interface [polypeptide binding]; other site 455488006316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 455488006317 substrate binding site [chemical binding]; other site 455488006318 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 455488006319 isocitrate dehydrogenase; Validated; Region: PRK07362 455488006320 YdjC-like protein; Region: YdjC; pfam04794 455488006321 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488006322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488006323 putative active site [active] 455488006324 heme pocket [chemical binding]; other site 455488006325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488006326 phosphorylation site [posttranslational modification] 455488006327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006328 ATP binding site [chemical binding]; other site 455488006329 Mg2+ binding site [ion binding]; other site 455488006330 G-X-G motif; other site 455488006331 Bifunctional nuclease; Region: DNase-RNase; cl00553 455488006332 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 455488006333 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 455488006334 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 455488006335 catalytic site [active] 455488006336 subunit interface [polypeptide binding]; other site 455488006337 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488006338 dihydroorotase; Validated; Region: pyrC; PRK09357 455488006339 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 455488006340 active site 455488006341 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 455488006342 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 455488006343 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 455488006344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488006345 active site 455488006346 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 455488006347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 455488006348 Catalytic site [active] 455488006349 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 455488006350 GTP-binding protein LepA; Provisional; Region: PRK05433 455488006351 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 455488006352 G1 box; other site 455488006353 putative GEF interaction site [polypeptide binding]; other site 455488006354 GTP/Mg2+ binding site [chemical binding]; other site 455488006355 Switch I region; other site 455488006356 G2 box; other site 455488006357 G3 box; other site 455488006358 Switch II region; other site 455488006359 G4 box; other site 455488006360 G5 box; other site 455488006361 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 455488006362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 455488006363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 455488006364 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 455488006365 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 455488006366 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 455488006367 active site 455488006368 dimer interface [polypeptide binding]; other site 455488006369 effector binding site; other site 455488006370 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 455488006371 TSCPD domain; Region: TSCPD; pfam12637 455488006372 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 455488006373 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 455488006374 putative active site [active] 455488006375 putative PHP Thumb interface [polypeptide binding]; other site 455488006376 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 455488006377 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 455488006378 generic binding surface I; other site 455488006379 generic binding surface II; other site 455488006380 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 455488006381 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488006382 Walker A motif; other site 455488006383 ATP binding site [chemical binding]; other site 455488006384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488006385 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488006386 catalytic residues [active] 455488006387 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 455488006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006389 active site 455488006390 phosphorylation site [posttranslational modification] 455488006391 intermolecular recognition site; other site 455488006392 dimerization interface [polypeptide binding]; other site 455488006393 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488006394 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 455488006395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006396 ATP binding site [chemical binding]; other site 455488006397 Mg2+ binding site [ion binding]; other site 455488006398 G-X-G motif; other site 455488006399 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 455488006400 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 455488006401 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488006402 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488006403 catalytic residue [active] 455488006404 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 455488006405 catalytic site [active] 455488006406 putative active site [active] 455488006407 putative substrate binding site [chemical binding]; other site 455488006408 HRDC domain; Region: HRDC; pfam00570 455488006409 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 455488006410 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488006411 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 455488006412 putative acyl-acceptor binding pocket; other site 455488006413 Response regulator receiver domain; Region: Response_reg; pfam00072 455488006414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006415 active site 455488006416 phosphorylation site [posttranslational modification] 455488006417 intermolecular recognition site; other site 455488006418 dimerization interface [polypeptide binding]; other site 455488006419 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 455488006420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 455488006421 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488006422 Walker A motif; other site 455488006423 ATP binding site [chemical binding]; other site 455488006424 Walker B motif; other site 455488006425 flagellar assembly protein H; Validated; Region: fliH; PRK06669 455488006426 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 455488006427 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 455488006428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488006429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 455488006430 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 455488006431 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 455488006432 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 455488006433 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 455488006434 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 455488006435 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 455488006436 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 455488006437 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 455488006438 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 455488006439 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 455488006440 DNA binding site [nucleotide binding] 455488006441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 455488006442 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 455488006443 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 455488006444 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 455488006445 RPB11 interaction site [polypeptide binding]; other site 455488006446 RPB12 interaction site [polypeptide binding]; other site 455488006447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 455488006448 RPB3 interaction site [polypeptide binding]; other site 455488006449 RPB1 interaction site [polypeptide binding]; other site 455488006450 RPB11 interaction site [polypeptide binding]; other site 455488006451 RPB10 interaction site [polypeptide binding]; other site 455488006452 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 455488006453 core dimer interface [polypeptide binding]; other site 455488006454 peripheral dimer interface [polypeptide binding]; other site 455488006455 L10 interface [polypeptide binding]; other site 455488006456 L11 interface [polypeptide binding]; other site 455488006457 putative EF-Tu interaction site [polypeptide binding]; other site 455488006458 putative EF-G interaction site [polypeptide binding]; other site 455488006459 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 455488006460 23S rRNA interface [nucleotide binding]; other site 455488006461 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 455488006462 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 455488006463 mRNA/rRNA interface [nucleotide binding]; other site 455488006464 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 455488006465 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 455488006466 23S rRNA interface [nucleotide binding]; other site 455488006467 L7/L12 interface [polypeptide binding]; other site 455488006468 putative thiostrepton binding site; other site 455488006469 L25 interface [polypeptide binding]; other site 455488006470 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 455488006471 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 455488006472 putative homodimer interface [polypeptide binding]; other site 455488006473 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 455488006474 heterodimer interface [polypeptide binding]; other site 455488006475 homodimer interface [polypeptide binding]; other site 455488006476 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 455488006477 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 455488006478 elongation factor Tu; Reviewed; Region: PRK00049 455488006479 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 455488006480 G1 box; other site 455488006481 GEF interaction site [polypeptide binding]; other site 455488006482 GTP/Mg2+ binding site [chemical binding]; other site 455488006483 Switch I region; other site 455488006484 G2 box; other site 455488006485 G3 box; other site 455488006486 Switch II region; other site 455488006487 G4 box; other site 455488006488 G5 box; other site 455488006489 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 455488006490 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 455488006491 Antibiotic Binding Site [chemical binding]; other site 455488006492 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 455488006493 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 455488006494 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 455488006495 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 455488006496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488006497 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 455488006498 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 455488006499 nucleotide binding site [chemical binding]; other site 455488006500 NEF interaction site [polypeptide binding]; other site 455488006501 SBD interface [polypeptide binding]; other site 455488006502 Protein of unknown function (DUF493); Region: DUF493; pfam04359 455488006503 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 455488006504 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 455488006505 putative active site [active] 455488006506 PhoH-like protein; Region: PhoH; pfam02562 455488006507 GAF domain; Region: GAF; cl17456 455488006508 GAF domain; Region: GAF_2; pfam13185 455488006509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488006510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488006511 metal binding site [ion binding]; metal-binding site 455488006512 active site 455488006513 I-site; other site 455488006514 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 455488006515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488006516 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488006517 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 455488006518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488006519 putative substrate translocation pore; other site 455488006520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488006521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488006522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488006523 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 455488006524 ApbE family; Region: ApbE; pfam02424 455488006525 FMN-binding domain; Region: FMN_bind; pfam04205 455488006526 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 455488006527 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 455488006528 FeoA domain; Region: FeoA; pfam04023 455488006529 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 455488006530 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 455488006531 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 455488006532 G1 box; other site 455488006533 GTP/Mg2+ binding site [chemical binding]; other site 455488006534 Switch I region; other site 455488006535 G2 box; other site 455488006536 G3 box; other site 455488006537 Switch II region; other site 455488006538 G4 box; other site 455488006539 G5 box; other site 455488006540 Nucleoside recognition; Region: Gate; pfam07670 455488006541 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 455488006542 Nucleoside recognition; Region: Gate; pfam07670 455488006543 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 455488006544 metal binding site 2 [ion binding]; metal-binding site 455488006545 putative DNA binding helix; other site 455488006546 metal binding site 1 [ion binding]; metal-binding site 455488006547 dimer interface [polypeptide binding]; other site 455488006548 structural Zn2+ binding site [ion binding]; other site 455488006549 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 455488006550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488006551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006552 ATP binding site [chemical binding]; other site 455488006553 Mg2+ binding site [ion binding]; other site 455488006554 G-X-G motif; other site 455488006555 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 455488006556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488006557 binding surface 455488006558 TPR motif; other site 455488006559 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488006560 Response regulator receiver domain; Region: Response_reg; pfam00072 455488006561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006562 active site 455488006563 phosphorylation site [posttranslational modification] 455488006564 intermolecular recognition site; other site 455488006565 dimerization interface [polypeptide binding]; other site 455488006566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488006567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488006568 metal binding site [ion binding]; metal-binding site 455488006569 active site 455488006570 I-site; other site 455488006571 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488006572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006573 active site 455488006574 phosphorylation site [posttranslational modification] 455488006575 intermolecular recognition site; other site 455488006576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006577 Walker A motif; other site 455488006578 ATP binding site [chemical binding]; other site 455488006579 Walker B motif; other site 455488006580 arginine finger; other site 455488006581 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488006582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488006583 dimer interface [polypeptide binding]; other site 455488006584 phosphorylation site [posttranslational modification] 455488006585 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 455488006586 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 455488006587 putative active site [active] 455488006588 putative metal binding site [ion binding]; other site 455488006589 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 455488006590 catalytic motif [active] 455488006591 Zn binding site [ion binding]; other site 455488006592 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488006593 PrkA AAA domain; Region: AAA_PrkA; smart00763 455488006594 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 455488006595 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488006596 rod-share determining protein MreBH; Provisional; Region: PRK13929 455488006597 nucleotide binding site [chemical binding]; other site 455488006598 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 455488006599 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 455488006600 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 455488006601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006602 Walker A motif; other site 455488006603 ATP binding site [chemical binding]; other site 455488006604 Walker B motif; other site 455488006605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 455488006606 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 455488006607 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 455488006608 dimerization interface 3.5A [polypeptide binding]; other site 455488006609 active site 455488006610 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 455488006611 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 455488006612 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 455488006613 Ligand Binding Site [chemical binding]; other site 455488006614 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 455488006615 active site 455488006616 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 455488006617 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 455488006618 ATP binding site [chemical binding]; other site 455488006619 substrate interface [chemical binding]; other site 455488006620 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 455488006621 CPxP motif; other site 455488006622 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 455488006623 ATP binding site [chemical binding]; other site 455488006624 substrate interface [chemical binding]; other site 455488006625 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 455488006626 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 455488006627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488006628 putative chaperone; Provisional; Region: PRK11678 455488006629 nucleotide binding site [chemical binding]; other site 455488006630 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 455488006631 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 455488006632 Ferredoxin [Energy production and conversion]; Region: COG1146 455488006633 4Fe-4S binding domain; Region: Fer4; pfam00037 455488006634 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 455488006635 Preprotein translocase SecG subunit; Region: SecG; pfam03840 455488006636 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 455488006637 triosephosphate isomerase; Provisional; Region: PRK14565 455488006638 substrate binding site [chemical binding]; other site 455488006639 dimer interface [polypeptide binding]; other site 455488006640 catalytic triad [active] 455488006641 Phosphoglycerate kinase; Region: PGK; pfam00162 455488006642 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 455488006643 substrate binding site [chemical binding]; other site 455488006644 hinge regions; other site 455488006645 ADP binding site [chemical binding]; other site 455488006646 catalytic site [active] 455488006647 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 455488006648 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 455488006649 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 455488006650 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 455488006651 Cupin domain; Region: Cupin_2; cl17218 455488006652 Sporulation related domain; Region: SPOR; pfam05036 455488006653 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 455488006654 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 455488006655 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 455488006656 active site 455488006657 HIGH motif; other site 455488006658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488006659 KMSK motif region; other site 455488006660 tRNA binding surface [nucleotide binding]; other site 455488006661 DALR anticodon binding domain; Region: DALR_1; smart00836 455488006662 anticodon binding site; other site 455488006663 tetratricopeptide repeat protein; Provisional; Region: PRK11788 455488006664 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 455488006665 nucleotide binding site/active site [active] 455488006666 HIT family signature motif; other site 455488006667 catalytic residue [active] 455488006668 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 455488006669 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 455488006670 tandem repeat interface [polypeptide binding]; other site 455488006671 oligomer interface [polypeptide binding]; other site 455488006672 active site residues [active] 455488006673 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 455488006674 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 455488006675 RNA binding site [nucleotide binding]; other site 455488006676 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 455488006677 RNA binding site [nucleotide binding]; other site 455488006678 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 455488006679 RNA binding site [nucleotide binding]; other site 455488006680 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 455488006681 RNA binding site [nucleotide binding]; other site 455488006682 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 455488006683 RNA binding site [nucleotide binding]; other site 455488006684 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 455488006685 RNA binding site [nucleotide binding]; other site 455488006686 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 455488006687 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 455488006688 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 455488006689 cytidylate kinase; Provisional; Region: cmk; PRK00023 455488006690 AAA domain; Region: AAA_17; pfam13207 455488006691 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 455488006692 CMP-binding site; other site 455488006693 The sites determining sugar specificity; other site 455488006694 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 455488006695 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 455488006696 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 455488006697 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 455488006698 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 455488006699 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 455488006700 dimer interface [polypeptide binding]; other site 455488006701 motif 1; other site 455488006702 active site 455488006703 motif 2; other site 455488006704 motif 3; other site 455488006705 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 455488006706 anticodon binding site; other site 455488006707 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 455488006708 urocanate hydratase; Provisional; Region: PRK05414 455488006709 imidazolonepropionase; Validated; Region: PRK09356 455488006710 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488006711 active site 455488006712 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 455488006713 active site 455488006714 metal binding site [ion binding]; metal-binding site 455488006715 homotetramer interface [polypeptide binding]; other site 455488006716 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 455488006717 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 455488006718 putative active site [active] 455488006719 putative dimer interface [polypeptide binding]; other site 455488006720 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 455488006721 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 455488006722 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 455488006723 putative substrate binding site [chemical binding]; other site 455488006724 putative ATP binding site [chemical binding]; other site 455488006725 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 455488006726 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 455488006727 active site 455488006728 hydrophilic channel; other site 455488006729 dimerization interface [polypeptide binding]; other site 455488006730 catalytic residues [active] 455488006731 active site lid [active] 455488006732 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 455488006733 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 455488006734 active site 455488006735 substrate binding site [chemical binding]; other site 455488006736 metal binding site [ion binding]; metal-binding site 455488006737 TIGR00159 family protein; Region: TIGR00159 455488006738 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 455488006739 dihydropteroate synthase; Region: DHPS; TIGR01496 455488006740 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 455488006741 substrate binding pocket [chemical binding]; other site 455488006742 dimer interface [polypeptide binding]; other site 455488006743 inhibitor binding site; inhibition site 455488006744 FtsH Extracellular; Region: FtsH_ext; pfam06480 455488006745 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 455488006746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006747 Walker A motif; other site 455488006748 ATP binding site [chemical binding]; other site 455488006749 Walker B motif; other site 455488006750 arginine finger; other site 455488006751 Peptidase family M41; Region: Peptidase_M41; pfam01434 455488006752 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 455488006753 TilS substrate C-terminal domain; Region: TilS_C; smart00977 455488006754 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 455488006755 PilZ domain; Region: PilZ; pfam07238 455488006756 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 455488006757 IHF dimer interface [polypeptide binding]; other site 455488006758 IHF - DNA interface [nucleotide binding]; other site 455488006759 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 455488006760 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 455488006761 active site 2 [active] 455488006762 active site 1 [active] 455488006763 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 455488006764 B12 binding site [chemical binding]; other site 455488006765 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 455488006766 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 455488006767 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 455488006768 Ligand Binding Site [chemical binding]; other site 455488006769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006770 active site 455488006771 phosphorylation site [posttranslational modification] 455488006772 intermolecular recognition site; other site 455488006773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488006774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488006775 dimer interface [polypeptide binding]; other site 455488006776 phosphorylation site [posttranslational modification] 455488006777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006778 ATP binding site [chemical binding]; other site 455488006779 Mg2+ binding site [ion binding]; other site 455488006780 G-X-G motif; other site 455488006781 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 455488006782 active site 455488006783 NTP binding site [chemical binding]; other site 455488006784 metal binding triad [ion binding]; metal-binding site 455488006785 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 455488006786 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 455488006787 Phage Tail Collar Domain; Region: Collar; pfam07484 455488006788 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 455488006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006790 Walker A motif; other site 455488006791 ATP binding site [chemical binding]; other site 455488006792 Walker B motif; other site 455488006793 arginine finger; other site 455488006794 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488006795 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 455488006796 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 455488006797 Protein export membrane protein; Region: SecD_SecF; cl14618 455488006798 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488006799 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488006800 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488006801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488006802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488006803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 455488006804 PAS fold; Region: PAS_4; pfam08448 455488006805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488006806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 455488006807 dimer interface [polypeptide binding]; other site 455488006808 phosphorylation site [posttranslational modification] 455488006809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006810 ATP binding site [chemical binding]; other site 455488006811 Mg2+ binding site [ion binding]; other site 455488006812 G-X-G motif; other site 455488006813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488006814 PAS domain; Region: PAS_9; pfam13426 455488006815 putative active site [active] 455488006816 heme pocket [chemical binding]; other site 455488006817 PAS domain; Region: PAS_9; pfam13426 455488006818 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488006819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488006820 putative active site [active] 455488006821 heme pocket [chemical binding]; other site 455488006822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488006823 dimer interface [polypeptide binding]; other site 455488006824 phosphorylation site [posttranslational modification] 455488006825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006826 ATP binding site [chemical binding]; other site 455488006827 Mg2+ binding site [ion binding]; other site 455488006828 G-X-G motif; other site 455488006829 Response regulator receiver domain; Region: Response_reg; pfam00072 455488006830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006831 active site 455488006832 phosphorylation site [posttranslational modification] 455488006833 intermolecular recognition site; other site 455488006834 dimerization interface [polypeptide binding]; other site 455488006835 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 455488006836 active site 455488006837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488006838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488006839 YciI-like protein; Reviewed; Region: PRK12866 455488006840 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 455488006841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488006842 dimerization interface [polypeptide binding]; other site 455488006843 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488006844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488006845 S-adenosylmethionine binding site [chemical binding]; other site 455488006846 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 455488006847 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 455488006848 30S subunit binding site; other site 455488006849 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488006850 DNA-binding site [nucleotide binding]; DNA binding site 455488006851 RNA-binding motif; other site 455488006852 YceI-like domain; Region: YceI; smart00867 455488006853 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488006854 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 455488006855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488006856 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488006857 active site 455488006858 metal binding site [ion binding]; metal-binding site 455488006859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488006860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488006861 dimer interface [polypeptide binding]; other site 455488006862 phosphorylation site [posttranslational modification] 455488006863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488006864 ATP binding site [chemical binding]; other site 455488006865 G-X-G motif; other site 455488006866 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488006867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488006868 active site 455488006869 phosphorylation site [posttranslational modification] 455488006870 intermolecular recognition site; other site 455488006871 dimerization interface [polypeptide binding]; other site 455488006872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488006873 Walker A motif; other site 455488006874 ATP binding site [chemical binding]; other site 455488006875 Walker B motif; other site 455488006876 arginine finger; other site 455488006877 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488006878 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488006879 Ligand Binding Site [chemical binding]; other site 455488006880 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488006881 Ligand Binding Site [chemical binding]; other site 455488006882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488006883 Ligand Binding Site [chemical binding]; other site 455488006884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488006885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488006886 DNA binding residues [nucleotide binding] 455488006887 dimerization interface [polypeptide binding]; other site 455488006888 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 455488006889 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 455488006890 Cl- selectivity filter; other site 455488006891 Cl- binding residues [ion binding]; other site 455488006892 pore gating glutamate residue; other site 455488006893 dimer interface [polypeptide binding]; other site 455488006894 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 455488006895 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488006896 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 455488006897 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 455488006898 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 455488006899 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 455488006900 active site 455488006901 homotetramer interface [polypeptide binding]; other site 455488006902 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 455488006903 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 455488006904 putative active site [active] 455488006905 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 455488006906 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 455488006907 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 455488006908 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 455488006909 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 455488006910 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 455488006911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488006912 acyl-activating enzyme (AAE) consensus motif; other site 455488006913 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 455488006914 acyl-activating enzyme (AAE) consensus motif; other site 455488006915 putative AMP binding site [chemical binding]; other site 455488006916 putative active site [active] 455488006917 putative CoA binding site [chemical binding]; other site 455488006918 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 455488006919 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 455488006920 active site 455488006921 catalytic residues [active] 455488006922 metal binding site [ion binding]; metal-binding site 455488006923 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 455488006924 EamA-like transporter family; Region: EamA; pfam00892 455488006925 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 455488006926 active site 455488006927 nucleophile elbow; other site 455488006928 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 455488006929 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 455488006930 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 455488006931 D-cysteine desulfhydrase; Validated; Region: PRK03910 455488006932 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 455488006933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488006934 catalytic residue [active] 455488006935 FOG: WD40 repeat [General function prediction only]; Region: COG2319 455488006936 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488006937 DTW domain; Region: DTW; cl01221 455488006938 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 455488006939 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 455488006940 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 455488006941 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 455488006942 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 455488006943 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 455488006944 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 455488006945 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488006946 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 455488006947 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 455488006948 4Fe-4S binding domain; Region: Fer4; pfam00037 455488006949 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 455488006950 Cl- selectivity filter; other site 455488006951 Cl- binding residues [ion binding]; other site 455488006952 pore gating glutamate residue; other site 455488006953 dimer interface [polypeptide binding]; other site 455488006954 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488006955 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 455488006956 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 455488006957 Zn binding site [ion binding]; other site 455488006958 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 455488006959 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 455488006960 putative NAD(P) binding site [chemical binding]; other site 455488006961 putative substrate binding site [chemical binding]; other site 455488006962 catalytic Zn binding site [ion binding]; other site 455488006963 structural Zn binding site [ion binding]; other site 455488006964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488006965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488006966 active site 455488006967 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488006968 active site 455488006969 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 455488006970 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 455488006971 RHS protein; Region: RHS; pfam03527 455488006972 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 455488006973 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 455488006974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 455488006975 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 455488006976 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 455488006977 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 455488006978 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 455488006979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 455488006980 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 455488006981 DNA-binding interface [nucleotide binding]; DNA binding site 455488006982 putative transposase OrfB; Reviewed; Region: PHA02517 455488006983 HTH-like domain; Region: HTH_21; pfam13276 455488006984 Integrase core domain; Region: rve; pfam00665 455488006985 Integrase core domain; Region: rve_3; pfam13683 455488006986 CARDB; Region: CARDB; pfam07705 455488006987 CARDB; Region: CARDB; pfam07705 455488006988 CARDB; Region: CARDB; pfam07705 455488006989 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 455488006990 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 455488006991 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 455488006992 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 455488006993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488006994 Walker A/P-loop; other site 455488006995 ATP binding site [chemical binding]; other site 455488006996 Q-loop/lid; other site 455488006997 ABC transporter signature motif; other site 455488006998 Walker B; other site 455488006999 D-loop; other site 455488007000 H-loop/switch region; other site 455488007001 methionine aminopeptidase; Provisional; Region: PRK12318 455488007002 SEC-C motif; Region: SEC-C; pfam02810 455488007003 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 455488007004 active site 455488007005 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 455488007006 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 455488007007 Hemerythrin-like domain; Region: Hr-like; cd12108 455488007008 Fe binding site [ion binding]; other site 455488007009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488007010 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488007011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488007012 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488007013 Walker A motif; other site 455488007014 ATP binding site [chemical binding]; other site 455488007015 Walker B motif; other site 455488007016 arginine finger; other site 455488007017 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 455488007018 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 455488007019 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 455488007020 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 455488007021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488007022 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488007023 Walker A motif; other site 455488007024 ATP binding site [chemical binding]; other site 455488007025 Walker B motif; other site 455488007026 arginine finger; other site 455488007027 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488007028 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 455488007029 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 455488007030 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 455488007031 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 455488007032 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 455488007033 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 455488007034 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 455488007035 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 455488007036 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 455488007037 FliG C-terminal domain; Region: FliG_C; pfam01706 455488007038 Flagellar assembly protein FliH; Region: FliH; pfam02108 455488007039 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 455488007040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 455488007041 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488007042 Walker A motif; other site 455488007043 ATP binding site [chemical binding]; other site 455488007044 Walker B motif; other site 455488007045 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 455488007046 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 455488007047 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 455488007048 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 455488007049 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 455488007050 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 455488007051 Flagellar protein (FlbD); Region: FlbD; pfam06289 455488007052 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 455488007053 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 455488007054 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 455488007055 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 455488007056 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488007057 ligand binding site [chemical binding]; other site 455488007058 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 455488007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007060 active site 455488007061 phosphorylation site [posttranslational modification] 455488007062 intermolecular recognition site; other site 455488007063 dimerization interface [polypeptide binding]; other site 455488007064 CheB methylesterase; Region: CheB_methylest; pfam01339 455488007065 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 455488007066 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 455488007067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488007068 S-adenosylmethionine binding site [chemical binding]; other site 455488007069 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 455488007070 putative CheA interaction surface; other site 455488007071 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 455488007072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488007073 dimerization interface [polypeptide binding]; other site 455488007074 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488007075 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488007076 dimer interface [polypeptide binding]; other site 455488007077 putative CheW interface [polypeptide binding]; other site 455488007078 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488007079 putative binding surface; other site 455488007080 active site 455488007081 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 455488007082 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 455488007083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007084 ATP binding site [chemical binding]; other site 455488007085 Mg2+ binding site [ion binding]; other site 455488007086 G-X-G motif; other site 455488007087 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 455488007088 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007090 active site 455488007091 phosphorylation site [posttranslational modification] 455488007092 intermolecular recognition site; other site 455488007093 dimerization interface [polypeptide binding]; other site 455488007094 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 455488007095 putative CheA interaction surface; other site 455488007096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488007097 dimer interface [polypeptide binding]; other site 455488007098 putative CheW interface [polypeptide binding]; other site 455488007099 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 455488007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007101 phosphorylation site [posttranslational modification] 455488007102 intermolecular recognition site; other site 455488007103 CheB methylesterase; Region: CheB_methylest; pfam01339 455488007104 CheD chemotactic sensory transduction; Region: CheD; cl00810 455488007105 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 455488007106 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488007107 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488007108 putative binding surface; other site 455488007109 active site 455488007110 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 455488007111 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 455488007112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007113 ATP binding site [chemical binding]; other site 455488007114 Mg2+ binding site [ion binding]; other site 455488007115 G-X-G motif; other site 455488007116 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 455488007117 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 455488007118 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007120 active site 455488007121 phosphorylation site [posttranslational modification] 455488007122 intermolecular recognition site; other site 455488007123 dimerization interface [polypeptide binding]; other site 455488007124 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007126 active site 455488007127 phosphorylation site [posttranslational modification] 455488007128 intermolecular recognition site; other site 455488007129 dimerization interface [polypeptide binding]; other site 455488007130 HDOD domain; Region: HDOD; pfam08668 455488007131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488007132 Zn2+ binding site [ion binding]; other site 455488007133 Mg2+ binding site [ion binding]; other site 455488007134 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 455488007135 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 455488007136 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 455488007137 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 455488007138 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 455488007139 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 455488007140 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 455488007141 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 455488007142 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 455488007143 FHIPEP family; Region: FHIPEP; pfam00771 455488007144 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 455488007145 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 455488007146 FHIPEP family; Region: FHIPEP; pfam00771 455488007147 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 455488007148 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488007149 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 455488007150 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488007151 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 455488007152 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 455488007153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488007154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488007155 DNA binding residues [nucleotide binding] 455488007156 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 455488007157 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 455488007158 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 455488007159 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 455488007160 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 455488007161 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 455488007162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 455488007163 Flagellar L-ring protein; Region: FlgH; pfam02107 455488007164 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 455488007165 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 455488007166 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 455488007167 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488007168 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488007169 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 455488007170 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 455488007171 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 455488007172 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 455488007173 flagellin; Provisional; Region: PRK12802 455488007174 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 455488007175 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 455488007176 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 455488007177 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 455488007178 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 455488007179 flagellin; Provisional; Region: PRK12802 455488007180 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 455488007181 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 455488007182 Flagellar protein FliS; Region: FliS; cl00654 455488007183 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 455488007184 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 455488007185 putative metal binding site; other site 455488007186 PilZ domain; Region: PilZ; cl01260 455488007187 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 455488007188 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 455488007189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488007190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488007191 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 455488007192 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 455488007193 dimer interface [polypeptide binding]; other site 455488007194 putative functional site; other site 455488007195 putative MPT binding site; other site 455488007196 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 455488007197 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488007198 ligand binding site [chemical binding]; other site 455488007199 flexible hinge region; other site 455488007200 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 455488007201 DNA binding site [nucleotide binding] 455488007202 sequence specific DNA binding site [nucleotide binding]; other site 455488007203 putative cAMP binding site [chemical binding]; other site 455488007204 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 455488007205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488007206 Ligand Binding Site [chemical binding]; other site 455488007207 FOG: CBS domain [General function prediction only]; Region: COG0517 455488007208 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803 455488007209 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 455488007210 heme-binding site [chemical binding]; other site 455488007211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488007212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488007213 dimer interface [polypeptide binding]; other site 455488007214 phosphorylation site [posttranslational modification] 455488007215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007216 ATP binding site [chemical binding]; other site 455488007217 Mg2+ binding site [ion binding]; other site 455488007218 G-X-G motif; other site 455488007219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007220 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007221 active site 455488007222 phosphorylation site [posttranslational modification] 455488007223 intermolecular recognition site; other site 455488007224 dimerization interface [polypeptide binding]; other site 455488007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007226 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007227 active site 455488007228 phosphorylation site [posttranslational modification] 455488007229 intermolecular recognition site; other site 455488007230 dimerization interface [polypeptide binding]; other site 455488007231 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007233 active site 455488007234 phosphorylation site [posttranslational modification] 455488007235 intermolecular recognition site; other site 455488007236 dimerization interface [polypeptide binding]; other site 455488007237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488007238 dimer interface [polypeptide binding]; other site 455488007239 phosphorylation site [posttranslational modification] 455488007240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007241 ATP binding site [chemical binding]; other site 455488007242 Mg2+ binding site [ion binding]; other site 455488007243 G-X-G motif; other site 455488007244 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488007245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007246 active site 455488007247 phosphorylation site [posttranslational modification] 455488007248 intermolecular recognition site; other site 455488007249 dimerization interface [polypeptide binding]; other site 455488007250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488007251 Walker A motif; other site 455488007252 ATP binding site [chemical binding]; other site 455488007253 Walker B motif; other site 455488007254 arginine finger; other site 455488007255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488007256 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 455488007257 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 455488007258 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 455488007259 FOG: CBS domain [General function prediction only]; Region: COG0517 455488007260 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488007261 FOG: CBS domain [General function prediction only]; Region: COG0517 455488007262 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488007263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488007264 Ligand Binding Site [chemical binding]; other site 455488007265 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 455488007266 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 455488007267 NAD binding site [chemical binding]; other site 455488007268 catalytic Zn binding site [ion binding]; other site 455488007269 structural Zn binding site [ion binding]; other site 455488007270 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 455488007271 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 455488007272 Isochorismatase family; Region: Isochorismatase; pfam00857 455488007273 catalytic triad [active] 455488007274 metal binding site [ion binding]; metal-binding site 455488007275 conserved cis-peptide bond; other site 455488007276 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 455488007277 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 455488007278 generic binding surface I; other site 455488007279 generic binding surface II; other site 455488007280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488007281 Zn2+ binding site [ion binding]; other site 455488007282 Mg2+ binding site [ion binding]; other site 455488007283 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 455488007284 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 455488007285 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 455488007286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 455488007287 active site 455488007288 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 455488007289 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 455488007290 active site 455488007291 HIGH motif; other site 455488007292 KMSKS motif; other site 455488007293 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 455488007294 anticodon binding site; other site 455488007295 tRNA binding surface [nucleotide binding]; other site 455488007296 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 455488007297 dimer interface [polypeptide binding]; other site 455488007298 putative tRNA-binding site [nucleotide binding]; other site 455488007299 DNA polymerase III, delta subunit; Region: holA; TIGR01128 455488007300 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 455488007301 DNA polymerase III subunit delta'; Validated; Region: PRK08485 455488007302 DivIVA protein; Region: DivIVA; pfam05103 455488007303 DNA polymerase I; Provisional; Region: PRK05755 455488007304 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 455488007305 active site 455488007306 metal binding site 1 [ion binding]; metal-binding site 455488007307 putative 5' ssDNA interaction site; other site 455488007308 metal binding site 3; metal-binding site 455488007309 metal binding site 2 [ion binding]; metal-binding site 455488007310 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 455488007311 putative DNA binding site [nucleotide binding]; other site 455488007312 putative metal binding site [ion binding]; other site 455488007313 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 455488007314 active site 455488007315 substrate binding site [chemical binding]; other site 455488007316 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 455488007317 active site 455488007318 DNA binding site [nucleotide binding] 455488007319 catalytic site [active] 455488007320 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488007321 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488007322 phosphopeptide binding site; other site 455488007323 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 455488007324 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 455488007325 dimer interface [polypeptide binding]; other site 455488007326 motif 1; other site 455488007327 active site 455488007328 motif 2; other site 455488007329 motif 3; other site 455488007330 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 455488007331 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 455488007332 putative substrate binding site [chemical binding]; other site 455488007333 putative ATP binding site [chemical binding]; other site 455488007334 Recombination protein O N terminal; Region: RecO_N; pfam11967 455488007335 DNA repair protein RecO; Region: reco; TIGR00613 455488007336 Recombination protein O C terminal; Region: RecO_C; pfam02565 455488007337 Helix-turn-helix domain; Region: HTH_25; pfam13413 455488007338 non-specific DNA binding site [nucleotide binding]; other site 455488007339 salt bridge; other site 455488007340 sequence-specific DNA binding site [nucleotide binding]; other site 455488007341 TPR repeat; Region: TPR_11; pfam13414 455488007342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488007343 binding surface 455488007344 TPR motif; other site 455488007345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488007346 binding surface 455488007347 TPR motif; other site 455488007348 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 455488007349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488007350 FeS/SAM binding site; other site 455488007351 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 455488007352 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488007353 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488007354 catalytic residue [active] 455488007355 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 455488007356 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 455488007357 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 455488007358 quinone interaction residues [chemical binding]; other site 455488007359 active site 455488007360 catalytic residues [active] 455488007361 FMN binding site [chemical binding]; other site 455488007362 substrate binding site [chemical binding]; other site 455488007363 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 455488007364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488007365 Coenzyme A binding pocket [chemical binding]; other site 455488007366 chaperone protein DnaJ; Provisional; Region: PRK14299 455488007367 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488007368 HSP70 interaction site [polypeptide binding]; other site 455488007369 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 455488007370 substrate binding site [polypeptide binding]; other site 455488007371 dimer interface [polypeptide binding]; other site 455488007372 HEAT repeats; Region: HEAT_2; pfam13646 455488007373 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 455488007374 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 455488007375 putative acyl-acceptor binding pocket; other site 455488007376 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 455488007377 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 455488007378 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 455488007379 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 455488007380 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 455488007381 active site 455488007382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 455488007383 Coenzyme A binding pocket [chemical binding]; other site 455488007384 Ycf46; Provisional; Region: ycf46; CHL00195 455488007385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 455488007386 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488007387 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 455488007388 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488007389 Walker A motif; other site 455488007390 ATP binding site [chemical binding]; other site 455488007391 Walker B motif; other site 455488007392 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 455488007393 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 455488007394 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 455488007395 dimer interface [polypeptide binding]; other site 455488007396 substrate binding site [chemical binding]; other site 455488007397 metal binding sites [ion binding]; metal-binding site 455488007398 serine O-acetyltransferase; Region: cysE; TIGR01172 455488007399 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 455488007400 trimer interface [polypeptide binding]; other site 455488007401 active site 455488007402 substrate binding site [chemical binding]; other site 455488007403 CoA binding site [chemical binding]; other site 455488007404 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 455488007405 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 455488007406 dimer interface [polypeptide binding]; other site 455488007407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488007408 catalytic residue [active] 455488007409 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 455488007410 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 455488007411 GIY-YIG motif/motif A; other site 455488007412 active site 455488007413 catalytic site [active] 455488007414 putative DNA binding site [nucleotide binding]; other site 455488007415 metal binding site [ion binding]; metal-binding site 455488007416 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 455488007417 excinuclease ABC subunit B; Provisional; Region: PRK05298 455488007418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488007419 ATP binding site [chemical binding]; other site 455488007420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488007421 nucleotide binding region [chemical binding]; other site 455488007422 ATP-binding site [chemical binding]; other site 455488007423 Ultra-violet resistance protein B; Region: UvrB; pfam12344 455488007424 UvrB/uvrC motif; Region: UVR; pfam02151 455488007425 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 455488007426 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 455488007427 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488007428 DNA-binding site [nucleotide binding]; DNA binding site 455488007429 RNA-binding motif; other site 455488007430 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 455488007431 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 455488007432 active site 455488007433 HIGH motif; other site 455488007434 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 455488007435 KMSKS motif; other site 455488007436 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 455488007437 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 455488007438 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 455488007439 substrate binding site; other site 455488007440 dimer interface; other site 455488007441 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 455488007442 homotrimer interaction site [polypeptide binding]; other site 455488007443 zinc binding site [ion binding]; other site 455488007444 CDP-binding sites; other site 455488007445 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 455488007446 Competence protein; Region: Competence; cl00471 455488007447 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 455488007448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488007449 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488007450 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488007451 phosphopeptide binding site; other site 455488007452 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 455488007453 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 455488007454 GDP-binding site [chemical binding]; other site 455488007455 ACT binding site; other site 455488007456 IMP binding site; other site 455488007457 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 455488007458 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 455488007459 dimer interface [polypeptide binding]; other site 455488007460 motif 1; other site 455488007461 motif 2; other site 455488007462 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 455488007463 active site 455488007464 motif 3; other site 455488007465 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 455488007466 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 455488007467 ligand binding site [chemical binding]; other site 455488007468 NAD binding site [chemical binding]; other site 455488007469 dimerization interface [polypeptide binding]; other site 455488007470 catalytic site [active] 455488007471 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 455488007472 putative L-serine binding site [chemical binding]; other site 455488007473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488007474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488007475 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 455488007476 AMIN domain; Region: AMIN; pfam11741 455488007477 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 455488007478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 455488007479 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 455488007480 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 455488007481 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488007482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 455488007483 ligand binding site [chemical binding]; other site 455488007484 flexible hinge region; other site 455488007485 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 455488007486 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 455488007487 dimerization interface [polypeptide binding]; other site 455488007488 putative ATP binding site [chemical binding]; other site 455488007489 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 455488007490 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 455488007491 active site 455488007492 substrate binding site [chemical binding]; other site 455488007493 cosubstrate binding site; other site 455488007494 catalytic site [active] 455488007495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488007496 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 455488007497 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 455488007498 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 455488007499 putative active site [active] 455488007500 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 455488007501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 455488007502 active site 455488007503 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14182 455488007504 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 455488007505 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 455488007506 homodimer interface [polypeptide binding]; other site 455488007507 NADP binding site [chemical binding]; other site 455488007508 substrate binding site [chemical binding]; other site 455488007509 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488007510 active site 455488007511 metal binding site [ion binding]; metal-binding site 455488007512 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 455488007513 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 455488007514 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 455488007515 lipoyl attachment site [posttranslational modification]; other site 455488007516 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 455488007517 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 455488007518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488007519 catalytic residue [active] 455488007520 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 455488007521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488007522 catalytic residue [active] 455488007523 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 455488007524 active site 455488007525 dimer interfaces [polypeptide binding]; other site 455488007526 catalytic residues [active] 455488007527 TonB C terminal; Region: TonB_2; pfam13103 455488007528 Transglycosylase; Region: Transgly; pfam00912 455488007529 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 455488007530 rRNA binding site [nucleotide binding]; other site 455488007531 predicted 30S ribosome binding site; other site 455488007532 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488007533 DNA-binding site [nucleotide binding]; DNA binding site 455488007534 RNA-binding motif; other site 455488007535 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 455488007536 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 455488007537 YceG-like family; Region: YceG; pfam02618 455488007538 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 455488007539 dimerization interface [polypeptide binding]; other site 455488007540 PrkA AAA domain; Region: AAA_PrkA; smart00763 455488007541 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 455488007542 hypothetical protein; Provisional; Region: PRK05325 455488007543 SpoVR like protein; Region: SpoVR; pfam04293 455488007544 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 455488007545 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488007546 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488007547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488007548 PAS domain; Region: PAS_9; pfam13426 455488007549 putative active site [active] 455488007550 heme pocket [chemical binding]; other site 455488007551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488007552 helicase 45; Provisional; Region: PTZ00424 455488007553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 455488007554 ATP binding site [chemical binding]; other site 455488007555 Mg++ binding site [ion binding]; other site 455488007556 motif III; other site 455488007557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488007558 nucleotide binding region [chemical binding]; other site 455488007559 ATP-binding site [chemical binding]; other site 455488007560 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 455488007561 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 455488007562 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 455488007563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488007564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 455488007565 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 455488007566 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 455488007567 metal ion-dependent adhesion site (MIDAS); other site 455488007568 CARDB; Region: CARDB; pfam07705 455488007569 Protein of unknown function (DUF1355); Region: DUF1355; pfam07090 455488007570 MG2 domain; Region: A2M_N; pfam01835 455488007571 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 455488007572 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 455488007573 PEGA domain; Region: PEGA; pfam08308 455488007574 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 455488007575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488007576 motif II; other site 455488007577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 455488007578 classical (c) SDRs; Region: SDR_c; cd05233 455488007579 NAD(P) binding site [chemical binding]; other site 455488007580 active site 455488007581 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 455488007582 dimer interface [polypeptide binding]; other site 455488007583 [2Fe-2S] cluster binding site [ion binding]; other site 455488007584 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 455488007585 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 455488007586 Domain of unknown function (DU1801); Region: DUF1801; cl17490 455488007587 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 455488007588 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 455488007589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488007590 binding surface 455488007591 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488007592 TPR motif; other site 455488007593 Transposase domain (DUF772); Region: DUF772; pfam05598 455488007594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488007595 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488007596 Domain of unknown function (DU1801); Region: DUF1801; cl17490 455488007597 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 455488007598 putative hydrophobic ligand binding site [chemical binding]; other site 455488007599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488007600 dimerization interface [polypeptide binding]; other site 455488007601 putative DNA binding site [nucleotide binding]; other site 455488007602 putative Zn2+ binding site [ion binding]; other site 455488007603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488007604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488007605 TPR repeat; Region: TPR_11; pfam13414 455488007606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488007607 binding surface 455488007608 TPR motif; other site 455488007609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488007610 short chain dehydrogenase; Provisional; Region: PRK07454 455488007611 NAD(P) binding site [chemical binding]; other site 455488007612 active site 455488007613 PAS domain S-box; Region: sensory_box; TIGR00229 455488007614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488007615 putative active site [active] 455488007616 heme pocket [chemical binding]; other site 455488007617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007619 ATP binding site [chemical binding]; other site 455488007620 Mg2+ binding site [ion binding]; other site 455488007621 G-X-G motif; other site 455488007622 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 455488007623 V-type ATP synthase subunit B; Provisional; Region: PRK04196 455488007624 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 455488007625 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 455488007626 Walker A motif homologous position; other site 455488007627 Walker B motif; other site 455488007628 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 455488007629 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488007630 V-type ATP synthase subunit A; Provisional; Region: PRK04192 455488007631 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 455488007632 Walker A motif/ATP binding site; other site 455488007633 Walker B motif; other site 455488007634 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 455488007635 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 455488007636 V-type ATP synthase subunit I; Validated; Region: PRK05771 455488007637 V-type ATP synthase subunit I; Validated; Region: PRK05771 455488007638 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 455488007639 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 455488007640 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488007641 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 455488007642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488007643 dimerization interface [polypeptide binding]; other site 455488007644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488007645 dimer interface [polypeptide binding]; other site 455488007646 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 455488007647 putative CheW interface [polypeptide binding]; other site 455488007648 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 455488007649 putative binding surface; other site 455488007650 active site 455488007651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007652 ATP binding site [chemical binding]; other site 455488007653 Mg2+ binding site [ion binding]; other site 455488007654 G-X-G motif; other site 455488007655 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007657 active site 455488007658 phosphorylation site [posttranslational modification] 455488007659 intermolecular recognition site; other site 455488007660 dimerization interface [polypeptide binding]; other site 455488007661 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 455488007662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007663 active site 455488007664 phosphorylation site [posttranslational modification] 455488007665 intermolecular recognition site; other site 455488007666 CheB methylesterase; Region: CheB_methylest; pfam01339 455488007667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488007668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488007669 dimer interface [polypeptide binding]; other site 455488007670 phosphorylation site [posttranslational modification] 455488007671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007672 ATP binding site [chemical binding]; other site 455488007673 Mg2+ binding site [ion binding]; other site 455488007674 G-X-G motif; other site 455488007675 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 455488007676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488007677 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488007678 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488007679 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 455488007680 ABC-2 type transporter; Region: ABC2_membrane; cl17235 455488007681 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 455488007682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488007683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488007684 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488007685 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 455488007686 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 455488007687 nudix motif; other site 455488007688 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 455488007689 Fe-S cluster binding site [ion binding]; other site 455488007690 active site 455488007691 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 455488007692 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 455488007693 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 455488007694 catalytic site [active] 455488007695 G-X2-G-X-G-K; other site 455488007696 hypothetical protein; Provisional; Region: PRK11820 455488007697 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 455488007698 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 455488007699 Trm112p-like protein; Region: Trm112p; cl01066 455488007700 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488007701 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488007702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488007703 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 455488007704 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488007705 active site 455488007706 nucleotide binding site [chemical binding]; other site 455488007707 HIGH motif; other site 455488007708 KMSKS motif; other site 455488007709 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 455488007710 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 455488007711 putative ribose interaction site [chemical binding]; other site 455488007712 putative ADP binding site [chemical binding]; other site 455488007713 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 455488007714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 455488007715 putative acyl-acceptor binding pocket; other site 455488007716 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 455488007717 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 455488007718 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 455488007719 putative active site [active] 455488007720 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 455488007721 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 455488007722 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488007723 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 455488007724 active site 455488007725 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 455488007726 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 455488007727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 455488007728 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 455488007729 Walker A/P-loop; other site 455488007730 ATP binding site [chemical binding]; other site 455488007731 Q-loop/lid; other site 455488007732 ABC transporter signature motif; other site 455488007733 Walker B; other site 455488007734 D-loop; other site 455488007735 H-loop/switch region; other site 455488007736 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 455488007737 elongation factor G; Reviewed; Region: PRK12740 455488007738 G1 box; other site 455488007739 GTP/Mg2+ binding site [chemical binding]; other site 455488007740 G2 box; other site 455488007741 Switch I region; other site 455488007742 G3 box; other site 455488007743 Switch II region; other site 455488007744 G4 box; other site 455488007745 G5 box; other site 455488007746 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 455488007747 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 455488007748 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 455488007749 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 455488007750 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 455488007751 active site 455488007752 acyl-activating enzyme (AAE) consensus motif; other site 455488007753 putative CoA binding site [chemical binding]; other site 455488007754 AMP binding site [chemical binding]; other site 455488007755 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 455488007756 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 455488007757 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 455488007758 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 455488007759 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 455488007760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488007761 catalytic residue [active] 455488007762 MarC family integral membrane protein; Region: MarC; pfam01914 455488007763 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 455488007764 Ligand binding site; other site 455488007765 Putative Catalytic site; other site 455488007766 DXD motif; other site 455488007767 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 455488007768 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 455488007769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488007770 dimerization interface [polypeptide binding]; other site 455488007771 putative DNA binding site [nucleotide binding]; other site 455488007772 putative Zn2+ binding site [ion binding]; other site 455488007773 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 455488007774 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 455488007775 4Fe-4S binding domain; Region: Fer4; pfam00037 455488007776 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 455488007777 thiosulfate reductase PhsA; Provisional; Region: PRK15488 455488007778 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 455488007779 putative [Fe4-S4] binding site [ion binding]; other site 455488007780 putative molybdopterin cofactor binding site [chemical binding]; other site 455488007781 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 455488007782 putative molybdopterin cofactor binding site; other site 455488007783 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 455488007784 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488007785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488007786 putative active site [active] 455488007787 heme pocket [chemical binding]; other site 455488007788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488007789 dimer interface [polypeptide binding]; other site 455488007790 phosphorylation site [posttranslational modification] 455488007791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488007792 ATP binding site [chemical binding]; other site 455488007793 Mg2+ binding site [ion binding]; other site 455488007794 G-X-G motif; other site 455488007795 Response regulator receiver domain; Region: Response_reg; pfam00072 455488007796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007797 active site 455488007798 phosphorylation site [posttranslational modification] 455488007799 intermolecular recognition site; other site 455488007800 dimerization interface [polypeptide binding]; other site 455488007801 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 455488007802 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 455488007803 putative Iron-sulfur protein interface [polypeptide binding]; other site 455488007804 proximal heme binding site [chemical binding]; other site 455488007805 distal heme binding site [chemical binding]; other site 455488007806 putative dimer interface [polypeptide binding]; other site 455488007807 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 455488007808 L-aspartate oxidase; Provisional; Region: PRK06175 455488007809 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 455488007810 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 455488007811 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 455488007812 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 455488007813 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488007814 putative ADP-binding pocket [chemical binding]; other site 455488007815 O-Antigen ligase; Region: Wzy_C; cl04850 455488007816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 455488007817 putative homodimer interface [polypeptide binding]; other site 455488007818 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 455488007819 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 455488007820 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 455488007821 putative active site [active] 455488007822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 455488007823 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 455488007824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488007825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488007826 catalytic residue [active] 455488007827 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488007828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 455488007829 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 455488007830 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 455488007831 phosphate binding site [ion binding]; other site 455488007832 putative substrate binding pocket [chemical binding]; other site 455488007833 dimer interface [polypeptide binding]; other site 455488007834 Bacterial sugar transferase; Region: Bac_transf; pfam02397 455488007835 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 455488007836 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 455488007837 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 455488007838 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 455488007839 SLBB domain; Region: SLBB; pfam10531 455488007840 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488007841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488007842 active site 455488007843 phosphorylation site [posttranslational modification] 455488007844 intermolecular recognition site; other site 455488007845 dimerization interface [polypeptide binding]; other site 455488007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488007847 Walker A motif; other site 455488007848 ATP binding site [chemical binding]; other site 455488007849 Walker B motif; other site 455488007850 arginine finger; other site 455488007851 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 455488007852 active site residue [active] 455488007853 Stage II sporulation protein; Region: SpoIID; pfam08486 455488007854 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 455488007855 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 455488007856 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 455488007857 homodimer interface [polypeptide binding]; other site 455488007858 substrate-cofactor binding pocket; other site 455488007859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488007860 catalytic residue [active] 455488007861 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488007862 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488007863 Walker A/P-loop; other site 455488007864 ATP binding site [chemical binding]; other site 455488007865 Q-loop/lid; other site 455488007866 ABC transporter signature motif; other site 455488007867 Walker B; other site 455488007868 D-loop; other site 455488007869 H-loop/switch region; other site 455488007870 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488007871 FtsX-like permease family; Region: FtsX; pfam02687 455488007872 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488007873 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488007874 short chain dehydrogenase; Provisional; Region: PRK07109 455488007875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488007876 NAD(P) binding site [chemical binding]; other site 455488007877 active site 455488007878 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 455488007879 putative catalytic site [active] 455488007880 putative metal binding site [ion binding]; other site 455488007881 putative phosphate binding site [ion binding]; other site 455488007882 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 455488007883 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 455488007884 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 455488007885 4Fe-4S binding domain; Region: Fer4; pfam00037 455488007886 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 455488007887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 455488007888 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 455488007889 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 455488007890 dimer interface [polypeptide binding]; other site 455488007891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488007892 catalytic residue [active] 455488007893 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 455488007894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488007895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 455488007896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488007897 Low affinity iron permease; Region: Iron_permease; cl12096 455488007898 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 455488007899 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 455488007900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488007901 Ligand Binding Site [chemical binding]; other site 455488007902 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 455488007903 FAD binding site [chemical binding]; other site 455488007904 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 455488007905 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 455488007906 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 455488007907 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 455488007908 putative catalytic site [active] 455488007909 putative metal binding site [ion binding]; other site 455488007910 putative phosphate binding site [ion binding]; other site 455488007911 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 455488007912 G1 box; other site 455488007913 GTP/Mg2+ binding site [chemical binding]; other site 455488007914 Switch I region; other site 455488007915 G2 box; other site 455488007916 G3 box; other site 455488007917 Switch II region; other site 455488007918 G4 box; other site 455488007919 G5 box; other site 455488007920 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 455488007921 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 455488007922 dephospho-CoA kinase; Region: TIGR00152 455488007923 CoA-binding site [chemical binding]; other site 455488007924 ATP-binding [chemical binding]; other site 455488007925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488007926 NAD(P) binding site [chemical binding]; other site 455488007927 active site 455488007928 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 455488007929 active site 2 [active] 455488007930 active site 1 [active] 455488007931 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 455488007932 active site 455488007933 catalytic site [active] 455488007934 TPR repeat; Region: TPR_11; pfam13414 455488007935 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 455488007936 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 455488007937 nucleotide binding site [chemical binding]; other site 455488007938 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 455488007939 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488007940 HSP70 interaction site [polypeptide binding]; other site 455488007941 ornithine carbamoyltransferase; Provisional; Region: PRK00779 455488007942 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 455488007943 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 455488007944 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 455488007945 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 455488007946 inhibitor-cofactor binding pocket; inhibition site 455488007947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488007948 catalytic residue [active] 455488007949 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 455488007950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488007951 Walker A motif; other site 455488007952 ATP binding site [chemical binding]; other site 455488007953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 455488007954 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 455488007955 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 455488007956 active site 455488007957 HslU subunit interaction site [polypeptide binding]; other site 455488007958 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 455488007959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488007960 active site 455488007961 DNA binding site [nucleotide binding] 455488007962 Int/Topo IB signature motif; other site 455488007963 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 455488007964 Glucose inhibited division protein A; Region: GIDA; pfam01134 455488007965 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 455488007966 DNA topoisomerase I; Validated; Region: PRK06599 455488007967 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 455488007968 active site 455488007969 interdomain interaction site; other site 455488007970 putative metal-binding site [ion binding]; other site 455488007971 nucleotide binding site [chemical binding]; other site 455488007972 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 455488007973 domain I; other site 455488007974 DNA binding groove [nucleotide binding] 455488007975 phosphate binding site [ion binding]; other site 455488007976 domain II; other site 455488007977 domain III; other site 455488007978 nucleotide binding site [chemical binding]; other site 455488007979 catalytic site [active] 455488007980 domain IV; other site 455488007981 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 455488007982 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 455488007983 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 455488007984 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 455488007985 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 455488007986 DNA protecting protein DprA; Region: dprA; TIGR00732 455488007987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488007988 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 455488007989 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 455488007990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488007991 dimerization interface [polypeptide binding]; other site 455488007992 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488007993 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488007994 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488007995 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488007996 metal binding site [ion binding]; metal-binding site 455488007997 active site 455488007998 I-site; other site 455488007999 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008001 active site 455488008002 phosphorylation site [posttranslational modification] 455488008003 intermolecular recognition site; other site 455488008004 dimerization interface [polypeptide binding]; other site 455488008005 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 455488008006 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 455488008007 active site 455488008008 metal binding site [ion binding]; metal-binding site 455488008009 MoxR-like ATPases [General function prediction only]; Region: COG0714 455488008010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488008011 Walker A motif; other site 455488008012 ATP binding site [chemical binding]; other site 455488008013 Walker B motif; other site 455488008014 arginine finger; other site 455488008015 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 455488008016 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 455488008017 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488008018 putative ADP-binding pocket [chemical binding]; other site 455488008019 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488008020 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 455488008021 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 455488008022 catalytic residues [active] 455488008023 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 455488008024 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 455488008025 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 455488008026 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488008027 Walker A motif; other site 455488008028 ATP binding site [chemical binding]; other site 455488008029 Walker B motif; other site 455488008030 PilZ domain; Region: PilZ; cl01260 455488008031 This domain is found in peptide chain release factors; Region: PCRF; smart00937 455488008032 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 455488008033 RF-1 domain; Region: RF-1; pfam00472 455488008034 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 455488008035 putative active site [active] 455488008036 catalytic triad [active] 455488008037 putative dimer interface [polypeptide binding]; other site 455488008038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 455488008039 Zn2+ binding site [ion binding]; other site 455488008040 Mg2+ binding site [ion binding]; other site 455488008041 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 455488008042 PhoH-like protein; Region: PhoH; pfam02562 455488008043 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488008044 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488008045 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 455488008046 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 455488008047 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 455488008048 homodimer interface [polypeptide binding]; other site 455488008049 metal binding site [ion binding]; metal-binding site 455488008050 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 455488008051 homodimer interface [polypeptide binding]; other site 455488008052 active site 455488008053 putative chemical substrate binding site [chemical binding]; other site 455488008054 metal binding site [ion binding]; metal-binding site 455488008055 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 455488008056 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 455488008057 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 455488008058 HIGH motif; other site 455488008059 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 455488008060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 455488008061 active site 455488008062 KMSKS motif; other site 455488008063 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 455488008064 tRNA binding surface [nucleotide binding]; other site 455488008065 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 455488008066 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 455488008067 putative dimer interface [polypeptide binding]; other site 455488008068 putative anticodon binding site; other site 455488008069 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 455488008070 homodimer interface [polypeptide binding]; other site 455488008071 motif 1; other site 455488008072 motif 2; other site 455488008073 active site 455488008074 motif 3; other site 455488008075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008076 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008077 active site 455488008078 phosphorylation site [posttranslational modification] 455488008079 intermolecular recognition site; other site 455488008080 dimerization interface [polypeptide binding]; other site 455488008081 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 455488008082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008083 active site 455488008084 phosphorylation site [posttranslational modification] 455488008085 intermolecular recognition site; other site 455488008086 dimerization interface [polypeptide binding]; other site 455488008087 CheB methylesterase; Region: CheB_methylest; pfam01339 455488008088 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 455488008089 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488008090 HEAT repeats; Region: HEAT_2; pfam13646 455488008091 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 455488008092 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 455488008093 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 455488008094 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 455488008095 AAA domain; Region: AAA_30; pfam13604 455488008096 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488008097 putative binding surface; other site 455488008098 active site 455488008099 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 455488008100 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 455488008101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008102 ATP binding site [chemical binding]; other site 455488008103 Mg2+ binding site [ion binding]; other site 455488008104 G-X-G motif; other site 455488008105 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 455488008106 leucyl aminopeptidase; Provisional; Region: PRK00913 455488008107 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 455488008108 putative RNA binding site [nucleotide binding]; other site 455488008109 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 455488008110 homopentamer interface [polypeptide binding]; other site 455488008111 active site 455488008112 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 455488008113 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 455488008114 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 455488008115 dimerization interface [polypeptide binding]; other site 455488008116 active site 455488008117 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 455488008118 Lumazine binding domain; Region: Lum_binding; pfam00677 455488008119 Lumazine binding domain; Region: Lum_binding; pfam00677 455488008120 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 455488008121 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 455488008122 catalytic motif [active] 455488008123 Zn binding site [ion binding]; other site 455488008124 RibD C-terminal domain; Region: RibD_C; cl17279 455488008125 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 455488008126 ATP cone domain; Region: ATP-cone; pfam03477 455488008127 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 455488008128 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 455488008129 dimer interface [polypeptide binding]; other site 455488008130 active site 455488008131 glycine-pyridoxal phosphate binding site [chemical binding]; other site 455488008132 folate binding site [chemical binding]; other site 455488008133 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 455488008134 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 455488008135 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 455488008136 dimer interface [polypeptide binding]; other site 455488008137 active site 455488008138 acyl carrier protein; Provisional; Region: acpP; PRK00982 455488008139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 455488008140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008141 NAD(P) binding site [chemical binding]; other site 455488008142 active site 455488008143 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 455488008144 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 455488008145 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 455488008146 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 455488008147 dimer interface [polypeptide binding]; other site 455488008148 active site 455488008149 CoA binding pocket [chemical binding]; other site 455488008150 putative phosphate acyltransferase; Provisional; Region: PRK05331 455488008151 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 455488008152 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 455488008153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488008154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008155 active site 455488008156 phosphorylation site [posttranslational modification] 455488008157 intermolecular recognition site; other site 455488008158 dimerization interface [polypeptide binding]; other site 455488008159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488008160 DNA binding residues [nucleotide binding] 455488008161 dimerization interface [polypeptide binding]; other site 455488008162 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 455488008163 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 455488008164 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 455488008165 GIY-YIG motif/motif A; other site 455488008166 active site 455488008167 catalytic site [active] 455488008168 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 455488008169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008170 NAD(P) binding site [chemical binding]; other site 455488008171 active site 455488008172 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 455488008173 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 455488008174 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 455488008175 putative active site [active] 455488008176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 455488008177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 455488008178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 455488008179 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488008180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008181 NAD(P) binding site [chemical binding]; other site 455488008182 active site 455488008183 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 455488008184 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 455488008185 putative ADP-binding pocket [chemical binding]; other site 455488008186 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 455488008187 Bacterial sugar transferase; Region: Bac_transf; pfam02397 455488008188 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 455488008189 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 455488008190 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 455488008191 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 455488008192 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 455488008193 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 455488008194 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 455488008195 active site 455488008196 dimer interface [polypeptide binding]; other site 455488008197 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 455488008198 Ligand Binding Site [chemical binding]; other site 455488008199 Molecular Tunnel; other site 455488008200 NAD synthetase; Reviewed; Region: nadE; PRK00876 455488008201 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 455488008202 homodimer interface [polypeptide binding]; other site 455488008203 NAD binding pocket [chemical binding]; other site 455488008204 ATP binding pocket [chemical binding]; other site 455488008205 Mg binding site [ion binding]; other site 455488008206 active-site loop [active] 455488008207 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 455488008208 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488008209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488008210 acyl-activating enzyme (AAE) consensus motif; other site 455488008211 AMP binding site [chemical binding]; other site 455488008212 active site 455488008213 CoA binding site [chemical binding]; other site 455488008214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488008215 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488008216 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 455488008217 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 455488008218 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 455488008219 trimer interface [polypeptide binding]; other site 455488008220 active site 455488008221 substrate binding site [chemical binding]; other site 455488008222 CoA binding site [chemical binding]; other site 455488008223 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488008224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 455488008225 active site 455488008226 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 455488008227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488008228 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 455488008229 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 455488008230 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 455488008231 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 455488008232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 455488008233 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 455488008234 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 455488008235 Probable Catalytic site; other site 455488008236 metal-binding site 455488008237 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488008238 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 455488008239 Probable Catalytic site; other site 455488008240 metal-binding site 455488008241 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 455488008242 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 455488008243 Ligand Binding Site [chemical binding]; other site 455488008244 Molecular Tunnel; other site 455488008245 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488008246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488008247 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 455488008248 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 455488008249 inhibitor-cofactor binding pocket; inhibition site 455488008250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488008251 catalytic residue [active] 455488008252 PKD domain; Region: PKD; pfam00801 455488008253 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 455488008254 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 455488008255 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 455488008256 putative ADP-binding pocket [chemical binding]; other site 455488008257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488008258 putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775 455488008259 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 455488008260 FAD binding pocket [chemical binding]; other site 455488008261 FAD binding motif [chemical binding]; other site 455488008262 phosphate binding motif [ion binding]; other site 455488008263 beta-alpha-beta structure motif; other site 455488008264 NAD binding pocket [chemical binding]; other site 455488008265 Iron coordination center [ion binding]; other site 455488008266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 455488008267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488008268 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 455488008269 diiron binding motif [ion binding]; other site 455488008270 Rhomboid family; Region: Rhomboid; cl11446 455488008271 RNA polymerase sigma factor; Provisional; Region: PRK12518 455488008272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488008273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488008274 active site 455488008275 ATP binding site [chemical binding]; other site 455488008276 substrate binding site [chemical binding]; other site 455488008277 activation loop (A-loop); other site 455488008278 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 455488008279 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 455488008280 cofactor binding site; other site 455488008281 metal binding site [ion binding]; metal-binding site 455488008282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488008283 Walker A/P-loop; other site 455488008284 ATP binding site [chemical binding]; other site 455488008285 ABC transporter; Region: ABC_tran; pfam00005 455488008286 Q-loop/lid; other site 455488008287 ABC transporter signature motif; other site 455488008288 Walker B; other site 455488008289 D-loop; other site 455488008290 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 455488008291 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488008292 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008294 active site 455488008295 phosphorylation site [posttranslational modification] 455488008296 intermolecular recognition site; other site 455488008297 dimerization interface [polypeptide binding]; other site 455488008298 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 455488008299 Na binding site [ion binding]; other site 455488008300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008302 dimer interface [polypeptide binding]; other site 455488008303 phosphorylation site [posttranslational modification] 455488008304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008305 ATP binding site [chemical binding]; other site 455488008306 Mg2+ binding site [ion binding]; other site 455488008307 G-X-G motif; other site 455488008308 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 455488008309 Uncharacterized conserved protein [Function unknown]; Region: COG4198 455488008310 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 455488008311 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 455488008312 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 455488008313 Uncharacterized conserved protein [Function unknown]; Region: COG1432 455488008314 NYN domain; Region: NYN; pfam01936 455488008315 putative metal binding site [ion binding]; other site 455488008316 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 455488008317 short chain dehydrogenase; Provisional; Region: PRK06701 455488008318 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 455488008319 NAD binding site [chemical binding]; other site 455488008320 metal binding site [ion binding]; metal-binding site 455488008321 active site 455488008322 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 455488008323 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 455488008324 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 455488008325 TadE-like protein; Region: TadE; pfam07811 455488008326 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 455488008327 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 455488008328 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 455488008329 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 455488008330 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 455488008331 AAA domain; Region: AAA_31; pfam13614 455488008332 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 455488008333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488008334 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 455488008335 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 455488008336 ATP binding site [chemical binding]; other site 455488008337 Walker A motif; other site 455488008338 hexamer interface [polypeptide binding]; other site 455488008339 Walker B motif; other site 455488008340 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 455488008341 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488008342 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 455488008343 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 455488008344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488008345 binding surface 455488008346 TPR motif; other site 455488008347 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 455488008348 Phospholipid methyltransferase; Region: PEMT; cl17370 455488008349 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 455488008350 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 455488008351 active site 455488008352 catalytic site [active] 455488008353 substrate binding site [chemical binding]; other site 455488008354 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 455488008355 DNA topoisomerase VI subunit A; Provisional; Region: PRK04342 455488008356 Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406 455488008357 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 455488008358 active site 455488008359 metal binding site [ion binding]; metal-binding site 455488008360 interdomain interaction site; other site 455488008361 DNA topoisomerase VI subunit B; Validated; Region: PRK04184 455488008362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008363 ATP binding site [chemical binding]; other site 455488008364 Mg2+ binding site [ion binding]; other site 455488008365 G-X-G motif; other site 455488008366 TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823 455488008367 anchoring element; other site 455488008368 dimer interface [polypeptide binding]; other site 455488008369 ATP binding site [chemical binding]; other site 455488008370 Peptidase family M48; Region: Peptidase_M48; cl12018 455488008371 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 455488008372 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 455488008373 putative NAD(P) binding site [chemical binding]; other site 455488008374 structural Zn binding site [ion binding]; other site 455488008375 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 455488008376 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 455488008377 catalytic triad [active] 455488008378 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 455488008379 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 455488008380 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 455488008381 EamA-like transporter family; Region: EamA; pfam00892 455488008382 epoxyqueuosine reductase; Region: TIGR00276 455488008383 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 455488008384 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 455488008385 DNA methylase; Region: N6_N4_Mtase; cl17433 455488008386 DNA methylase; Region: N6_N4_Mtase; pfam01555 455488008387 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 455488008388 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 455488008389 active site 455488008390 Zn binding site [ion binding]; other site 455488008391 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 455488008392 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 455488008393 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 455488008394 nickel binding site [ion binding]; other site 455488008395 Flagellin N-methylase; Region: FliB; pfam03692 455488008396 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488008397 Cysteine-rich domain; Region: CCG; pfam02754 455488008398 Cysteine-rich domain; Region: CCG; pfam02754 455488008399 FAD binding domain; Region: FAD_binding_4; pfam01565 455488008400 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 455488008401 FAD binding domain; Region: FAD_binding_4; pfam01565 455488008402 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 455488008403 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 455488008404 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 455488008405 Methyltransferase domain; Region: Methyltransf_26; pfam13659 455488008406 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 455488008407 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 455488008408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 455488008409 dimerization interface [polypeptide binding]; other site 455488008410 DNA binding residues [nucleotide binding] 455488008411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 455488008412 Integrase core domain; Region: rve; pfam00665 455488008413 transposase/IS protein; Provisional; Region: PRK09183 455488008414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488008415 Walker A motif; other site 455488008416 ATP binding site [chemical binding]; other site 455488008417 Walker B motif; other site 455488008418 arginine finger; other site 455488008419 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 455488008420 Fic/DOC family; Region: Fic; cl00960 455488008421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008422 short chain dehydrogenase; Provisional; Region: PRK07041 455488008423 NAD(P) binding site [chemical binding]; other site 455488008424 active site 455488008425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488008426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488008427 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 455488008428 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 455488008429 putative NAD(P) binding site [chemical binding]; other site 455488008430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 455488008431 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 455488008432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488008433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488008434 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 455488008435 rRNA binding site [nucleotide binding]; other site 455488008436 predicted 30S ribosome binding site; other site 455488008437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488008438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 455488008439 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 455488008440 homotrimer interaction site [polypeptide binding]; other site 455488008441 putative active site [active] 455488008442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488008443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488008444 DNA binding site [nucleotide binding] 455488008445 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 455488008446 TAP-like protein; Region: Abhydrolase_4; pfam08386 455488008447 Methyltransferase domain; Region: Methyltransf_23; pfam13489 455488008448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488008449 S-adenosylmethionine binding site [chemical binding]; other site 455488008450 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 455488008451 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 455488008452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488008453 active site 455488008454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 455488008455 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 455488008456 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 455488008457 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 455488008458 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 455488008459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 455488008460 catalytic core [active] 455488008461 Cupin domain; Region: Cupin_2; cl17218 455488008462 phosphate acetyltransferase; Reviewed; Region: PRK05632 455488008463 DRTGG domain; Region: DRTGG; pfam07085 455488008464 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 455488008465 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 455488008466 propionate/acetate kinase; Provisional; Region: PRK12379 455488008467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008468 NAD(P) binding site [chemical binding]; other site 455488008469 active site 455488008470 Helix-turn-helix domain; Region: HTH_17; pfam12728 455488008471 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 455488008472 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 455488008473 Cupin domain; Region: Cupin_2; cl17218 455488008474 Cytochrome c552; Region: Cytochrom_C552; pfam02335 455488008475 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 455488008476 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 455488008477 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 455488008478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488008479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488008480 acyl-activating enzyme (AAE) consensus motif; other site 455488008481 AMP binding site [chemical binding]; other site 455488008482 active site 455488008483 CoA binding site [chemical binding]; other site 455488008484 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 455488008485 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 455488008486 active site 455488008487 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 455488008488 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 455488008489 active site 455488008490 catalytic site [active] 455488008491 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 455488008492 Transposase domain (DUF772); Region: DUF772; pfam05598 455488008493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488008494 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488008495 Protein of unknown function, DUF488; Region: DUF488; cl01246 455488008496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488008497 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 455488008498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 455488008499 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 455488008500 dimer interface [polypeptide binding]; other site 455488008501 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488008502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008503 active site 455488008504 phosphorylation site [posttranslational modification] 455488008505 intermolecular recognition site; other site 455488008506 dimerization interface [polypeptide binding]; other site 455488008507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488008508 DNA binding site [nucleotide binding] 455488008509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008510 HAMP domain; Region: HAMP; pfam00672 455488008511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008512 dimer interface [polypeptide binding]; other site 455488008513 phosphorylation site [posttranslational modification] 455488008514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008515 ATP binding site [chemical binding]; other site 455488008516 G-X-G motif; other site 455488008517 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 455488008518 Predicted dinucleotide-utilizing enzyme [General function prediction only]; Region: COG1712 455488008519 MarR family; Region: MarR_2; pfam12802 455488008520 Amidase; Region: Amidase; cl11426 455488008521 Amidase; Region: Amidase; cl11426 455488008522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488008523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488008524 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940 455488008525 N-glycosyltransferase; Provisional; Region: PRK11204 455488008526 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 455488008527 DXD motif; other site 455488008528 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 455488008529 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 455488008530 putative active site [active] 455488008531 putative metal binding site [ion binding]; other site 455488008532 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488008533 Peptidase family M48; Region: Peptidase_M48; cl12018 455488008534 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 455488008535 ATP binding site [chemical binding]; other site 455488008536 substrate interface [chemical binding]; other site 455488008537 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 455488008538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488008539 Walker A motif; other site 455488008540 ATP binding site [chemical binding]; other site 455488008541 Walker B motif; other site 455488008542 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 455488008543 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 455488008544 4Fe-4S binding domain; Region: Fer4; pfam00037 455488008545 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 455488008546 L-aspartate oxidase; Provisional; Region: PRK06175 455488008547 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 455488008548 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 455488008549 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 455488008550 putative Iron-sulfur protein interface [polypeptide binding]; other site 455488008551 proximal heme binding site [chemical binding]; other site 455488008552 distal heme binding site [chemical binding]; other site 455488008553 putative dimer interface [polypeptide binding]; other site 455488008554 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 455488008555 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 455488008556 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 455488008557 PA/protease or protease-like domain interface [polypeptide binding]; other site 455488008558 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 455488008559 Zn binding site [ion binding]; other site 455488008560 PEGA domain; Region: PEGA; pfam08308 455488008561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488008562 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488008563 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 455488008564 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488008565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008567 dimer interface [polypeptide binding]; other site 455488008568 phosphorylation site [posttranslational modification] 455488008569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008570 Mg2+ binding site [ion binding]; other site 455488008571 G-X-G motif; other site 455488008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008573 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008574 active site 455488008575 phosphorylation site [posttranslational modification] 455488008576 intermolecular recognition site; other site 455488008577 dimerization interface [polypeptide binding]; other site 455488008578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008580 dimer interface [polypeptide binding]; other site 455488008581 phosphorylation site [posttranslational modification] 455488008582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008583 ATP binding site [chemical binding]; other site 455488008584 Mg2+ binding site [ion binding]; other site 455488008585 G-X-G motif; other site 455488008586 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008588 active site 455488008589 phosphorylation site [posttranslational modification] 455488008590 intermolecular recognition site; other site 455488008591 dimerization interface [polypeptide binding]; other site 455488008592 circadian clock protein KaiC; Reviewed; Region: PRK09302 455488008593 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488008594 Walker A motif; other site 455488008595 ATP binding site [chemical binding]; other site 455488008596 Walker B motif; other site 455488008597 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488008598 Walker A motif; other site 455488008599 ATP binding site [chemical binding]; other site 455488008600 Walker B motif; other site 455488008601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008603 dimer interface [polypeptide binding]; other site 455488008604 phosphorylation site [posttranslational modification] 455488008605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008606 ATP binding site [chemical binding]; other site 455488008607 G-X-G motif; other site 455488008608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488008609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008610 active site 455488008611 phosphorylation site [posttranslational modification] 455488008612 intermolecular recognition site; other site 455488008613 dimerization interface [polypeptide binding]; other site 455488008614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488008615 DNA binding site [nucleotide binding] 455488008616 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 455488008617 putative hydrophobic ligand binding site [chemical binding]; other site 455488008618 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 455488008619 active site 455488008620 catalytic residues [active] 455488008621 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 455488008622 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 455488008623 active site 455488008624 DNA binding site [nucleotide binding] 455488008625 Int/Topo IB signature motif; other site 455488008626 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 455488008627 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 455488008628 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 455488008629 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 455488008630 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 455488008631 DEAD-like helicases superfamily; Region: DEXDc; smart00487 455488008632 ATP binding site [chemical binding]; other site 455488008633 Mg++ binding site [ion binding]; other site 455488008634 motif III; other site 455488008635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488008636 nucleotide binding region [chemical binding]; other site 455488008637 ATP-binding site [chemical binding]; other site 455488008638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488008639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488008640 dimer interface [polypeptide binding]; other site 455488008641 phosphorylation site [posttranslational modification] 455488008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488008643 ATP binding site [chemical binding]; other site 455488008644 Mg2+ binding site [ion binding]; other site 455488008645 G-X-G motif; other site 455488008646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488008647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008648 active site 455488008649 phosphorylation site [posttranslational modification] 455488008650 intermolecular recognition site; other site 455488008651 dimerization interface [polypeptide binding]; other site 455488008652 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 455488008653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488008654 putative substrate translocation pore; other site 455488008655 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 455488008656 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 455488008657 putative ligand binding site [chemical binding]; other site 455488008658 putative NAD binding site [chemical binding]; other site 455488008659 putative catalytic site [active] 455488008660 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 455488008661 L-serine binding site [chemical binding]; other site 455488008662 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 455488008663 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488008664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488008665 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 455488008666 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 455488008667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488008668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 455488008669 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488008670 carboxyltransferase (CT) interaction site; other site 455488008671 biotinylation site [posttranslational modification]; other site 455488008672 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 455488008673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 455488008674 Outer membrane efflux protein; Region: OEP; pfam02321 455488008675 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488008676 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488008677 FtsX-like permease family; Region: FtsX; pfam02687 455488008678 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488008679 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488008680 Walker A/P-loop; other site 455488008681 ATP binding site [chemical binding]; other site 455488008682 Q-loop/lid; other site 455488008683 ABC transporter signature motif; other site 455488008684 Walker B; other site 455488008685 D-loop; other site 455488008686 H-loop/switch region; other site 455488008687 macrolide transporter subunit MacA; Provisional; Region: PRK11578 455488008688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488008689 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488008690 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 455488008691 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 455488008692 Histidine kinase; Region: His_kinase; pfam06580 455488008693 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 455488008694 ATP binding site [chemical binding]; other site 455488008695 Mg2+ binding site [ion binding]; other site 455488008696 G-X-G motif; other site 455488008697 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 455488008698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008699 active site 455488008700 phosphorylation site [posttranslational modification] 455488008701 intermolecular recognition site; other site 455488008702 dimerization interface [polypeptide binding]; other site 455488008703 LytTr DNA-binding domain; Region: LytTR; smart00850 455488008704 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 455488008705 FAD binding domain; Region: FAD_binding_4; pfam01565 455488008706 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 455488008707 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488008708 L-lactate permease; Region: Lactate_perm; cl00701 455488008709 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 455488008710 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488008711 Cysteine-rich domain; Region: CCG; pfam02754 455488008712 Cysteine-rich domain; Region: CCG; pfam02754 455488008713 iron-sulfur cluster-binding protein; Region: TIGR00273 455488008714 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 455488008715 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 455488008716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488008717 S-adenosylmethionine binding site [chemical binding]; other site 455488008718 TPR repeat; Region: TPR_11; pfam13414 455488008719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488008720 binding surface 455488008721 TPR motif; other site 455488008722 Protein of unknown function, DUF399; Region: DUF399; pfam04187 455488008723 PilZ domain; Region: PilZ; pfam07238 455488008724 Predicted methyltransferase [General function prediction only]; Region: COG3897 455488008725 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 455488008726 ATP binding site [chemical binding]; other site 455488008727 Uncharacterized conserved protein [Function unknown]; Region: COG3268 455488008728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008729 NAD(P) binding site [chemical binding]; other site 455488008730 active site 455488008731 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 455488008732 UPF0126 domain; Region: UPF0126; pfam03458 455488008733 Predicted membrane protein [Function unknown]; Region: COG2860 455488008734 Predicted membrane protein [Function unknown]; Region: COG2246 455488008735 GtrA-like protein; Region: GtrA; pfam04138 455488008736 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 455488008737 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488008738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488008739 S-adenosylmethionine binding site [chemical binding]; other site 455488008740 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 455488008741 homodimer interface [polypeptide binding]; other site 455488008742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488008743 catalytic residue [active] 455488008744 Response regulator receiver domain; Region: Response_reg; pfam00072 455488008745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488008746 active site 455488008747 phosphorylation site [posttranslational modification] 455488008748 intermolecular recognition site; other site 455488008749 dimerization interface [polypeptide binding]; other site 455488008750 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 455488008751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488008752 non-specific DNA binding site [nucleotide binding]; other site 455488008753 salt bridge; other site 455488008754 sequence-specific DNA binding site [nucleotide binding]; other site 455488008755 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 455488008756 Domain of unknown function (DUF955); Region: DUF955; pfam06114 455488008757 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 455488008758 malate synthase A; Region: malate_syn_A; TIGR01344 455488008759 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 455488008760 active site 455488008761 isocitrate lyase; Provisional; Region: PRK15063 455488008762 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 455488008763 tetramer interface [polypeptide binding]; other site 455488008764 active site 455488008765 Mg2+/Mn2+ binding site [ion binding]; other site 455488008766 Hemerythrin-like domain; Region: Hr-like; cd12108 455488008767 4-alpha-glucanotransferase; Provisional; Region: PRK14508 455488008768 trehalose synthase; Region: treS_nterm; TIGR02456 455488008769 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 455488008770 active site 455488008771 catalytic site [active] 455488008772 FOG: CBS domain [General function prediction only]; Region: COG0517 455488008773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 455488008774 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 455488008775 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 455488008776 ligand binding site [chemical binding]; other site 455488008777 homodimer interface [polypeptide binding]; other site 455488008778 NAD(P) binding site [chemical binding]; other site 455488008779 trimer interface B [polypeptide binding]; other site 455488008780 trimer interface A [polypeptide binding]; other site 455488008781 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 455488008782 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 455488008783 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 455488008784 AMP-binding domain protein; Validated; Region: PRK08315 455488008785 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 455488008786 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 455488008787 acyl-activating enzyme (AAE) consensus motif; other site 455488008788 acyl-activating enzyme (AAE) consensus motif; other site 455488008789 putative AMP binding site [chemical binding]; other site 455488008790 putative active site [active] 455488008791 putative CoA binding site [chemical binding]; other site 455488008792 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 455488008793 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 455488008794 NADP binding site [chemical binding]; other site 455488008795 dimer interface [polypeptide binding]; other site 455488008796 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 455488008797 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 455488008798 TPP-binding site [chemical binding]; other site 455488008799 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 455488008800 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 455488008801 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 455488008802 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 455488008803 dimer interface [polypeptide binding]; other site 455488008804 PYR/PP interface [polypeptide binding]; other site 455488008805 TPP binding site [chemical binding]; other site 455488008806 substrate binding site [chemical binding]; other site 455488008807 pyruvate carboxylase; Reviewed; Region: PRK12999 455488008808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488008809 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488008810 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 455488008811 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 455488008812 active site 455488008813 catalytic residues [active] 455488008814 metal binding site [ion binding]; metal-binding site 455488008815 homodimer binding site [polypeptide binding]; other site 455488008816 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488008817 carboxyltransferase (CT) interaction site; other site 455488008818 biotinylation site [posttranslational modification]; other site 455488008819 Hemerythrin; Region: Hemerythrin; cd12107 455488008820 Fe binding site [ion binding]; other site 455488008821 Hemerythrin; Region: Hemerythrin; cd12107 455488008822 Fe binding site [ion binding]; other site 455488008823 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 455488008824 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 455488008825 FAD binding domain; Region: FAD_binding_4; pfam01565 455488008826 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 455488008827 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 455488008828 Cysteine-rich domain; Region: CCG; pfam02754 455488008829 glutamate dehydrogenase; Provisional; Region: PRK09414 455488008830 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 455488008831 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 455488008832 NAD(P) binding site [chemical binding]; other site 455488008833 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 455488008834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488008835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488008836 active site 455488008837 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 455488008838 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 455488008839 NAD(P) binding site [chemical binding]; other site 455488008840 catalytic residues [active] 455488008841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008842 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 455488008843 NAD(P) binding site [chemical binding]; other site 455488008844 active site 455488008845 photolyase PhrII; Region: phr2; TIGR00591 455488008846 DNA photolyase; Region: DNA_photolyase; pfam00875 455488008847 Protein of unknown function (DUF523); Region: DUF523; pfam04463 455488008848 Uncharacterized conserved protein [Function unknown]; Region: COG3272 455488008849 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 455488008850 Predicted membrane protein [Function unknown]; Region: COG3671 455488008851 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 455488008852 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 455488008853 nucleotide binding site [chemical binding]; other site 455488008854 putative NEF/HSP70 interaction site [polypeptide binding]; other site 455488008855 SBD interface [polypeptide binding]; other site 455488008856 DNA-K related protein; Region: DUF3731; pfam12531 455488008857 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 455488008858 nucleotide binding site [chemical binding]; other site 455488008859 putative NEF/HSP70 interaction site [polypeptide binding]; other site 455488008860 SBD interface [polypeptide binding]; other site 455488008861 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 455488008862 Protein of unknown function DUF72; Region: DUF72; pfam01904 455488008863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488008864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488008865 active site 455488008866 catalytic tetrad [active] 455488008867 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 455488008868 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 455488008869 active site 455488008870 catalytic residues [active] 455488008871 metal binding site [ion binding]; metal-binding site 455488008872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488008873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488008874 active site 455488008875 catalytic tetrad [active] 455488008876 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 455488008877 intracellular protease, PfpI family; Region: PfpI; TIGR01382 455488008878 proposed catalytic triad [active] 455488008879 conserved cys residue [active] 455488008880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488008881 S-adenosylmethionine binding site [chemical binding]; other site 455488008882 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 455488008883 helicase 45; Provisional; Region: PTZ00424 455488008884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 455488008885 ATP binding site [chemical binding]; other site 455488008886 putative Mg++ binding site [ion binding]; other site 455488008887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488008888 nucleotide binding region [chemical binding]; other site 455488008889 ATP-binding site [chemical binding]; other site 455488008890 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 455488008891 RNA binding site [nucleotide binding]; other site 455488008892 Hemerythrin family; Region: Hemerythrin-like; cl15774 455488008893 Fe binding site [ion binding]; other site 455488008894 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488008895 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488008896 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488008897 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 455488008898 putative deacylase active site [active] 455488008899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488008900 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 455488008901 metal-binding site 455488008902 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 455488008903 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 455488008904 Ligand binding site; other site 455488008905 Putative Catalytic site; other site 455488008906 DXD motif; other site 455488008907 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 455488008908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488008909 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 455488008910 metal-binding site 455488008911 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 455488008912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488008913 active site 455488008914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488008915 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 455488008916 putative ADP-binding pocket [chemical binding]; other site 455488008917 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 455488008918 ZU5 domain; Region: ZU5; cl02517 455488008919 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 455488008920 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 455488008921 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 455488008922 NHL repeat; Region: NHL; pfam01436 455488008923 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488008924 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008925 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008926 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488008927 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488008928 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008929 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008930 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008931 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488008932 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488008933 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008934 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008935 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008936 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 455488008937 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008938 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 455488008939 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008940 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008941 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008942 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008943 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008944 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488008945 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 455488008946 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 455488008947 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 455488008948 Uncharacterized conserved protein [Function unknown]; Region: COG3391 455488008949 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 455488008950 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 455488008951 chaperone protein DnaJ; Provisional; Region: PRK14276 455488008952 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 455488008953 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 455488008954 active site 455488008955 dimer interface [polypeptide binding]; other site 455488008956 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 455488008957 dimer interface [polypeptide binding]; other site 455488008958 active site 455488008959 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 455488008960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 455488008961 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 455488008962 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 455488008963 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 455488008964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488008965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488008966 homodimer interface [polypeptide binding]; other site 455488008967 catalytic residue [active] 455488008968 argininosuccinate synthase; Validated; Region: PRK05370 455488008969 argininosuccinate synthase; Provisional; Region: PRK13820 455488008970 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 455488008971 4Fe-4S binding domain; Region: Fer4; cl02805 455488008972 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 455488008973 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 455488008974 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 455488008975 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 455488008976 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 455488008977 PAS fold; Region: PAS; pfam00989 455488008978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488008979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488008980 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488008981 Walker A motif; other site 455488008982 ATP binding site [chemical binding]; other site 455488008983 Walker B motif; other site 455488008984 arginine finger; other site 455488008985 Rubrerythrin [Energy production and conversion]; Region: COG1592 455488008986 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 455488008987 binuclear metal center [ion binding]; other site 455488008988 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 455488008989 iron binding site [ion binding]; other site 455488008990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488008991 dimerization interface [polypeptide binding]; other site 455488008992 putative DNA binding site [nucleotide binding]; other site 455488008993 putative Zn2+ binding site [ion binding]; other site 455488008994 Predicted transcriptional regulators [Transcription]; Region: COG1733 455488008995 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 455488008996 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 455488008997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488008998 NAD(P) binding site [chemical binding]; other site 455488008999 active site 455488009000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488009001 active site 455488009002 catalytic tetrad [active] 455488009003 deoxyhypusine synthase; Region: dhys; TIGR00321 455488009004 Deoxyhypusine synthase; Region: DS; cl00826 455488009005 Deoxyhypusine synthase; Region: DS; cl00826 455488009006 Peptidase family M1; Region: Peptidase_M1; pfam01433 455488009007 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 455488009008 Zn binding site [ion binding]; other site 455488009009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488009010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488009011 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488009012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488009013 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 455488009014 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 455488009015 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 455488009016 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 455488009017 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 455488009018 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 455488009019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 455488009020 catalytic loop [active] 455488009021 iron binding site [ion binding]; other site 455488009022 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 455488009023 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 455488009024 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 455488009025 XdhC Rossmann domain; Region: XdhC_C; pfam13478 455488009026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488009027 active site 455488009028 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 455488009029 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 455488009030 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 455488009031 active site 455488009032 Zn binding site [ion binding]; other site 455488009033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488009034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009035 dimer interface [polypeptide binding]; other site 455488009036 phosphorylation site [posttranslational modification] 455488009037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009038 ATP binding site [chemical binding]; other site 455488009039 Mg2+ binding site [ion binding]; other site 455488009040 G-X-G motif; other site 455488009041 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 455488009042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488009043 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488009044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 455488009045 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488009046 Walker A/P-loop; other site 455488009047 ATP binding site [chemical binding]; other site 455488009048 Q-loop/lid; other site 455488009049 ABC transporter signature motif; other site 455488009050 Walker B; other site 455488009051 D-loop; other site 455488009052 H-loop/switch region; other site 455488009053 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 455488009054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488009055 Walker A/P-loop; other site 455488009056 ATP binding site [chemical binding]; other site 455488009057 Q-loop/lid; other site 455488009058 ABC transporter signature motif; other site 455488009059 Walker B; other site 455488009060 D-loop; other site 455488009061 H-loop/switch region; other site 455488009062 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 455488009063 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 455488009064 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 455488009065 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 455488009066 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 455488009067 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 455488009068 Acetokinase family; Region: Acetate_kinase; cl17229 455488009069 propionate/acetate kinase; Provisional; Region: PRK12379 455488009070 putative phosphoketolase; Provisional; Region: PRK05261 455488009071 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 455488009072 TPP-binding site; other site 455488009073 XFP C-terminal domain; Region: XFP_C; pfam09363 455488009074 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 455488009075 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 455488009076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 455488009077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 455488009078 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 455488009079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488009080 Walker A/P-loop; other site 455488009081 ATP binding site [chemical binding]; other site 455488009082 Q-loop/lid; other site 455488009083 ABC transporter signature motif; other site 455488009084 Walker B; other site 455488009085 D-loop; other site 455488009086 H-loop/switch region; other site 455488009087 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 455488009088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488009089 dimer interface [polypeptide binding]; other site 455488009090 conserved gate region; other site 455488009091 putative PBP binding loops; other site 455488009092 ABC-ATPase subunit interface; other site 455488009093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 455488009094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488009095 dimer interface [polypeptide binding]; other site 455488009096 conserved gate region; other site 455488009097 putative PBP binding loops; other site 455488009098 ABC-ATPase subunit interface; other site 455488009099 RNA polymerase factor sigma-70; Validated; Region: PRK08241 455488009100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488009101 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 455488009102 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 455488009103 YCII-related domain; Region: YCII; cl00999 455488009104 YCII-related domain; Region: YCII; cl00999 455488009105 DoxX-like family; Region: DoxX_2; pfam13564 455488009106 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 455488009107 Uncharacterized conserved protein [Function unknown]; Region: COG2128 455488009108 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 455488009109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488009110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488009111 DNA binding residues [nucleotide binding] 455488009112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488009113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488009114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488009115 dimerization interface [polypeptide binding]; other site 455488009116 short chain dehydrogenase; Provisional; Region: PRK07041 455488009117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488009118 NAD(P) binding site [chemical binding]; other site 455488009119 active site 455488009120 GTPase RsgA; Reviewed; Region: PRK01889 455488009121 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 455488009122 GTPase/Zn-binding domain interface [polypeptide binding]; other site 455488009123 GTP/Mg2+ binding site [chemical binding]; other site 455488009124 G4 box; other site 455488009125 G5 box; other site 455488009126 G1 box; other site 455488009127 Switch I region; other site 455488009128 G2 box; other site 455488009129 G3 box; other site 455488009130 Switch II region; other site 455488009131 PilZ domain; Region: PilZ; cl01260 455488009132 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488009133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009134 active site 455488009135 phosphorylation site [posttranslational modification] 455488009136 intermolecular recognition site; other site 455488009137 dimerization interface [polypeptide binding]; other site 455488009138 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 455488009139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 455488009140 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 455488009141 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 455488009142 active site 455488009143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488009144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488009145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 455488009146 classical (c) SDRs; Region: SDR_c; cd05233 455488009147 NAD(P) binding site [chemical binding]; other site 455488009148 active site 455488009149 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 455488009150 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 455488009151 homodimer interface [polypeptide binding]; other site 455488009152 substrate-cofactor binding pocket; other site 455488009153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488009154 catalytic residue [active] 455488009155 Heavy-metal-associated domain; Region: HMA; pfam00403 455488009156 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 455488009157 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488009158 active site 455488009159 CHRD domain; Region: CHRD; cl06473 455488009160 CHRD domain; Region: CHRD; pfam07452 455488009161 CHRD domain; Region: CHRD; pfam07452 455488009162 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 455488009163 iron-sulfur cluster [ion binding]; other site 455488009164 [2Fe-2S] cluster binding site [ion binding]; other site 455488009165 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 455488009166 iron-sulfur cluster [ion binding]; other site 455488009167 [2Fe-2S] cluster binding site [ion binding]; other site 455488009168 YceI-like domain; Region: YceI; pfam04264 455488009169 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488009170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 455488009171 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 455488009172 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 455488009173 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 455488009174 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 455488009175 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 455488009176 active site 455488009177 homodimer interface [polypeptide binding]; other site 455488009178 SAM binding site [chemical binding]; other site 455488009179 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 455488009180 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 455488009181 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 455488009182 Transposase domain (DUF772); Region: DUF772; pfam05598 455488009183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488009184 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488009185 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 455488009186 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 455488009187 Uncharacterized conserved protein [Function unknown]; Region: COG1656 455488009188 Protein of unknown function DUF82; Region: DUF82; pfam01927 455488009189 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 455488009190 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 455488009191 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 455488009192 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 455488009193 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 455488009194 putative NAD(P) binding site [chemical binding]; other site 455488009195 putative substrate binding site [chemical binding]; other site 455488009196 catalytic Zn binding site [ion binding]; other site 455488009197 structural Zn binding site [ion binding]; other site 455488009198 dimer interface [polypeptide binding]; other site 455488009199 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 455488009200 RibD C-terminal domain; Region: RibD_C; cl17279 455488009201 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 455488009202 ABC-2 type transporter; Region: ABC2_membrane; cl17235 455488009203 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 455488009204 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 455488009205 Walker A/P-loop; other site 455488009206 ATP binding site [chemical binding]; other site 455488009207 Q-loop/lid; other site 455488009208 ABC transporter signature motif; other site 455488009209 Walker B; other site 455488009210 D-loop; other site 455488009211 H-loop/switch region; other site 455488009212 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 455488009213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 455488009214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488009215 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 455488009216 putative effector binding pocket; other site 455488009217 putative dimerization interface [polypeptide binding]; other site 455488009218 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 455488009219 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 455488009220 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 455488009221 metal binding site [ion binding]; metal-binding site 455488009222 putative dimer interface [polypeptide binding]; other site 455488009223 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 455488009224 DNA-binding site [nucleotide binding]; DNA binding site 455488009225 RNA-binding motif; other site 455488009226 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 455488009227 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 455488009228 Multicopper oxidase; Region: Cu-oxidase; pfam00394 455488009229 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 455488009230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 455488009231 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 455488009232 dinuclear metal binding motif [ion binding]; other site 455488009233 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 455488009234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488009235 Walker A/P-loop; other site 455488009236 ATP binding site [chemical binding]; other site 455488009237 Q-loop/lid; other site 455488009238 ABC transporter signature motif; other site 455488009239 Walker B; other site 455488009240 D-loop; other site 455488009241 H-loop/switch region; other site 455488009242 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 455488009243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488009244 dimer interface [polypeptide binding]; other site 455488009245 conserved gate region; other site 455488009246 ABC-ATPase subunit interface; other site 455488009247 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 455488009248 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 455488009249 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 455488009250 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 455488009251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488009252 motif II; other site 455488009253 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 455488009254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488009255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009256 dimer interface [polypeptide binding]; other site 455488009257 phosphorylation site [posttranslational modification] 455488009258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009259 ATP binding site [chemical binding]; other site 455488009260 Mg2+ binding site [ion binding]; other site 455488009261 G-X-G motif; other site 455488009262 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 455488009263 CheB methylesterase; Region: CheB_methylest; pfam01339 455488009264 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 455488009265 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 455488009266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488009267 S-adenosylmethionine binding site [chemical binding]; other site 455488009268 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 455488009269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009270 dimer interface [polypeptide binding]; other site 455488009271 phosphorylation site [posttranslational modification] 455488009272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009273 ATP binding site [chemical binding]; other site 455488009274 Mg2+ binding site [ion binding]; other site 455488009275 G-X-G motif; other site 455488009276 Response regulator receiver domain; Region: Response_reg; pfam00072 455488009277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009278 active site 455488009279 phosphorylation site [posttranslational modification] 455488009280 intermolecular recognition site; other site 455488009281 dimerization interface [polypeptide binding]; other site 455488009282 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 455488009283 Putative glucoamylase; Region: Glycoamylase; pfam10091 455488009284 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 455488009285 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 455488009286 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 455488009287 Fatty acid desaturase; Region: FA_desaturase; pfam00487 455488009288 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 455488009289 putative di-iron ligands [ion binding]; other site 455488009290 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 455488009291 Predicted membrane protein [Function unknown]; Region: COG2323 455488009292 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 455488009293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488009294 NAD(P) binding site [chemical binding]; other site 455488009295 short chain dehydrogenase; Provisional; Region: PRK06523 455488009296 active site 455488009297 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 455488009298 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 455488009299 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 455488009300 Prostaglandin dehydrogenases; Region: PGDH; cd05288 455488009301 NAD(P) binding site [chemical binding]; other site 455488009302 substrate binding site [chemical binding]; other site 455488009303 dimer interface [polypeptide binding]; other site 455488009304 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 455488009305 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 455488009306 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 455488009307 FOG: CBS domain [General function prediction only]; Region: COG0517 455488009308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488009309 FOG: CBS domain [General function prediction only]; Region: COG0517 455488009310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 455488009311 FOG: CBS domain [General function prediction only]; Region: COG0517 455488009312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 455488009313 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 455488009314 dimer interface [polypeptide binding]; other site 455488009315 RibD C-terminal domain; Region: RibD_C; cl17279 455488009316 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 455488009317 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 455488009318 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 455488009319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488009320 S-adenosylmethionine binding site [chemical binding]; other site 455488009321 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 455488009322 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 455488009323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 455488009324 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 455488009325 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 455488009326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488009327 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 455488009328 NAD(P) binding site [chemical binding]; other site 455488009329 active site 455488009330 Uncharacterized conserved protein [Function unknown]; Region: COG4925 455488009331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009332 binding surface 455488009333 TPR motif; other site 455488009334 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 455488009335 DoxX-like family; Region: DoxX_2; pfam13564 455488009336 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 455488009337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488009338 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 455488009339 proline aminopeptidase P II; Provisional; Region: PRK10879 455488009340 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 455488009341 active site 455488009342 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 455488009343 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 455488009344 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 455488009345 Bacterial transcriptional activator domain; Region: BTAD; smart01043 455488009346 AAA ATPase domain; Region: AAA_16; pfam13191 455488009347 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 455488009348 FeoA domain; Region: FeoA; pfam04023 455488009349 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 455488009350 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 455488009351 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 455488009352 G1 box; other site 455488009353 GTP/Mg2+ binding site [chemical binding]; other site 455488009354 Switch I region; other site 455488009355 G2 box; other site 455488009356 G3 box; other site 455488009357 Switch II region; other site 455488009358 G4 box; other site 455488009359 G5 box; other site 455488009360 Nucleoside recognition; Region: Gate; pfam07670 455488009361 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 455488009362 Nucleoside recognition; Region: Gate; pfam07670 455488009363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 455488009364 NAD(P) binding site [chemical binding]; other site 455488009365 Helix-turn-helix domain; Region: HTH_17; pfam12728 455488009366 Transposase domain (DUF772); Region: DUF772; pfam05598 455488009367 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488009368 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488009369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488009370 non-specific DNA binding site [nucleotide binding]; other site 455488009371 salt bridge; other site 455488009372 sequence-specific DNA binding site [nucleotide binding]; other site 455488009373 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 455488009374 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 455488009375 active site 455488009376 Helix-turn-helix domain; Region: HTH_17; cl17695 455488009377 hypothetical protein; Region: PHA00661 455488009378 putative protease; Region: PHA00666 455488009379 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 455488009380 putative amphipathic alpha helix; other site 455488009381 ferredoxin-NADP+ reductase; Region: PLN02852 455488009382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 455488009383 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 455488009384 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 455488009385 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 455488009386 Multicopper oxidase; Region: Cu-oxidase; pfam00394 455488009387 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 455488009388 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 455488009389 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 455488009390 dimer interface [polypeptide binding]; other site 455488009391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488009392 catalytic residue [active] 455488009393 FOG: CBS domain [General function prediction only]; Region: COG0517 455488009394 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 455488009395 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 455488009396 Sel1-like repeats; Region: SEL1; smart00671 455488009397 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 455488009398 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 455488009399 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 455488009400 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 455488009401 Peptidase family M48; Region: Peptidase_M48; cl12018 455488009402 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 455488009403 signal recognition particle protein; Provisional; Region: PRK10867 455488009404 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 455488009405 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 455488009406 P loop; other site 455488009407 GTP binding site [chemical binding]; other site 455488009408 Signal peptide binding domain; Region: SRP_SPB; pfam02978 455488009409 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 455488009410 putative ligand binding pocket/active site [active] 455488009411 putative metal binding site [ion binding]; other site 455488009412 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 455488009413 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 455488009414 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 455488009415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009416 TPR motif; other site 455488009417 binding surface 455488009418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009419 binding surface 455488009420 TPR motif; other site 455488009421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 455488009422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009423 binding surface 455488009424 TPR motif; other site 455488009425 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 455488009426 TMP-binding site; other site 455488009427 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 455488009428 putative active site; other site 455488009429 putative metal binding residues [ion binding]; other site 455488009430 signature motif; other site 455488009431 putative triphosphate binding site [ion binding]; other site 455488009432 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488009433 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488009434 active site 455488009435 metal binding site [ion binding]; metal-binding site 455488009436 CotH protein; Region: CotH; pfam08757 455488009437 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488009438 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488009439 phosphopeptide binding site; other site 455488009440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009441 binding surface 455488009442 TPR motif; other site 455488009443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009444 binding surface 455488009445 TPR motif; other site 455488009446 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 455488009447 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 455488009448 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 455488009449 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488009450 SnoaL-like domain; Region: SnoaL_3; pfam13474 455488009451 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 455488009452 active site 455488009453 substrate binding site [chemical binding]; other site 455488009454 ATP binding site [chemical binding]; other site 455488009455 TPR repeat; Region: TPR_11; pfam13414 455488009456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009457 binding surface 455488009458 TPR motif; other site 455488009459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009460 binding surface 455488009461 TPR motif; other site 455488009462 TPR repeat; Region: TPR_11; pfam13414 455488009463 TPR repeat; Region: TPR_11; pfam13414 455488009464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009465 binding surface 455488009466 TPR motif; other site 455488009467 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488009468 phosphopeptide binding site; other site 455488009469 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488009470 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488009471 phosphopeptide binding site; other site 455488009472 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 455488009473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488009474 Walker A motif; other site 455488009475 ATP binding site [chemical binding]; other site 455488009476 Walker B motif; other site 455488009477 arginine finger; other site 455488009478 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488009479 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488009480 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 455488009481 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 455488009482 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488009483 ligand binding site [chemical binding]; other site 455488009484 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488009485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009486 active site 455488009487 phosphorylation site [posttranslational modification] 455488009488 intermolecular recognition site; other site 455488009489 dimerization interface [polypeptide binding]; other site 455488009490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488009491 Walker A motif; other site 455488009492 ATP binding site [chemical binding]; other site 455488009493 Walker B motif; other site 455488009494 arginine finger; other site 455488009495 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488009496 Transglycosylase; Region: Transgly; pfam00912 455488009497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 455488009498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 455488009499 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 455488009500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009501 dimer interface [polypeptide binding]; other site 455488009502 phosphorylation site [posttranslational modification] 455488009503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009504 ATP binding site [chemical binding]; other site 455488009505 Mg2+ binding site [ion binding]; other site 455488009506 G-X-G motif; other site 455488009507 Peptidase S46; Region: Peptidase_S46; pfam10459 455488009508 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 455488009509 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 455488009510 quinolinate synthetase; Provisional; Region: PRK09375 455488009511 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488009512 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488009513 active site 455488009514 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 455488009515 Found in ATP-dependent protease La (LON); Region: LON; smart00464 455488009516 Found in ATP-dependent protease La (LON); Region: LON; smart00464 455488009517 Mediator complex protein; Region: Med11; pfam10280 455488009518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488009519 Walker A motif; other site 455488009520 ATP binding site [chemical binding]; other site 455488009521 Walker B motif; other site 455488009522 arginine finger; other site 455488009523 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 455488009524 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 455488009525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488009526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488009527 catalytic residue [active] 455488009528 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 455488009529 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 455488009530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488009531 Walker A motif; other site 455488009532 ATP binding site [chemical binding]; other site 455488009533 Walker B motif; other site 455488009534 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 455488009535 Clp protease; Region: CLP_protease; pfam00574 455488009536 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 455488009537 oligomer interface [polypeptide binding]; other site 455488009538 active site residues [active] 455488009539 trigger factor; Region: tig; TIGR00115 455488009540 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 455488009541 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 455488009542 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 455488009543 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 455488009544 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 455488009545 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 455488009546 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 455488009547 Ligand binding site; other site 455488009548 Putative Catalytic site; other site 455488009549 DXD motif; other site 455488009550 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 455488009551 active site 455488009552 dimerization interface [polypeptide binding]; other site 455488009553 ribonuclease PH; Reviewed; Region: rph; PRK00173 455488009554 Ribonuclease PH; Region: RNase_PH_bact; cd11362 455488009555 hexamer interface [polypeptide binding]; other site 455488009556 active site 455488009557 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 455488009558 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 455488009559 active site 455488009560 metal binding site [ion binding]; metal-binding site 455488009561 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 455488009562 dimerization interface [polypeptide binding]; other site 455488009563 putative ATP binding site [chemical binding]; other site 455488009564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009565 binding surface 455488009566 TPR motif; other site 455488009567 TPR repeat; Region: TPR_11; pfam13414 455488009568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 455488009569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009570 binding surface 455488009571 TPR motif; other site 455488009572 Outer membrane lipoprotein; Region: YfiO; pfam13525 455488009573 RecX family; Region: RecX; cl00936 455488009574 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 455488009575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488009576 ATP binding site [chemical binding]; other site 455488009577 Walker B motif; other site 455488009578 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 455488009579 PLD-like domain; Region: PLDc_2; pfam13091 455488009580 putative active site [active] 455488009581 catalytic site [active] 455488009582 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 455488009583 PLD-like domain; Region: PLDc_2; pfam13091 455488009584 putative active site [active] 455488009585 catalytic site [active] 455488009586 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 455488009587 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 455488009588 23S rRNA interface [nucleotide binding]; other site 455488009589 L3 interface [polypeptide binding]; other site 455488009590 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 455488009591 Part of AAA domain; Region: AAA_19; pfam13245 455488009592 Family description; Region: UvrD_C_2; pfam13538 455488009593 DoxX; Region: DoxX; pfam07681 455488009594 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 455488009595 CGNR zinc finger; Region: zf-CGNR; pfam11706 455488009596 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 455488009597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488009598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488009599 putative substrate translocation pore; other site 455488009600 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488009601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488009602 active site 455488009603 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 455488009604 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 455488009605 putative C-terminal domain interface [polypeptide binding]; other site 455488009606 putative GSH binding site (G-site) [chemical binding]; other site 455488009607 putative dimer interface [polypeptide binding]; other site 455488009608 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 455488009609 N-terminal domain interface [polypeptide binding]; other site 455488009610 dimer interface [polypeptide binding]; other site 455488009611 substrate binding pocket (H-site) [chemical binding]; other site 455488009612 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488009613 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488009614 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488009615 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 455488009616 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 455488009617 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 455488009618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488009619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488009620 dimerization interface [polypeptide binding]; other site 455488009621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009622 dimer interface [polypeptide binding]; other site 455488009623 phosphorylation site [posttranslational modification] 455488009624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009625 ATP binding site [chemical binding]; other site 455488009626 Mg2+ binding site [ion binding]; other site 455488009627 G-X-G motif; other site 455488009628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488009629 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 455488009630 Walker A/P-loop; other site 455488009631 ATP binding site [chemical binding]; other site 455488009632 ABC transporter signature motif; other site 455488009633 Walker B; other site 455488009634 D-loop; other site 455488009635 H-loop/switch region; other site 455488009636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488009637 Walker A/P-loop; other site 455488009638 ATP binding site [chemical binding]; other site 455488009639 Q-loop/lid; other site 455488009640 ABC transporter signature motif; other site 455488009641 Walker B; other site 455488009642 D-loop; other site 455488009643 H-loop/switch region; other site 455488009644 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488009645 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488009646 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 455488009647 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 455488009648 active site 455488009649 dimerization interface [polypeptide binding]; other site 455488009650 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 455488009651 active site 455488009652 metal binding site [ion binding]; metal-binding site 455488009653 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 455488009654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488009655 catalytic residues [active] 455488009656 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 455488009657 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 455488009658 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 455488009659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 455488009660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 455488009661 Beta-lactamase; Region: Beta-lactamase; pfam00144 455488009662 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 455488009663 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 455488009664 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 455488009665 dimer interface [polypeptide binding]; other site 455488009666 catalytic triad [active] 455488009667 acetyl-CoA synthetase; Provisional; Region: PRK00174 455488009668 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 455488009669 active site 455488009670 CoA binding site [chemical binding]; other site 455488009671 acyl-activating enzyme (AAE) consensus motif; other site 455488009672 AMP binding site [chemical binding]; other site 455488009673 acetate binding site [chemical binding]; other site 455488009674 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 455488009675 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 455488009676 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 455488009677 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 455488009678 glutathione S-transferase; Provisional; Region: PRK15113 455488009679 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 455488009680 C-terminal domain interface [polypeptide binding]; other site 455488009681 GSH binding site (G-site) [chemical binding]; other site 455488009682 dimer interface [polypeptide binding]; other site 455488009683 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 455488009684 N-terminal domain interface [polypeptide binding]; other site 455488009685 putative dimer interface [polypeptide binding]; other site 455488009686 putative substrate binding pocket (H-site) [chemical binding]; other site 455488009687 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488009688 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488009689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488009690 dimer interface [polypeptide binding]; other site 455488009691 putative CheW interface [polypeptide binding]; other site 455488009692 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 455488009693 Protein of unknown function, DUF481; Region: DUF481; pfam04338 455488009694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488009695 ATP binding site [chemical binding]; other site 455488009696 putative Mg++ binding site [ion binding]; other site 455488009697 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488009698 nucleotide binding region [chemical binding]; other site 455488009699 ATP-binding site [chemical binding]; other site 455488009700 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 455488009701 Uncharacterized conserved protein [Function unknown]; Region: COG4095 455488009702 Protein of unknown function, DUF488; Region: DUF488; pfam04343 455488009703 RF-1 domain; Region: RF-1; pfam00472 455488009704 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488009705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488009706 Walker A/P-loop; other site 455488009707 ATP binding site [chemical binding]; other site 455488009708 Q-loop/lid; other site 455488009709 ABC transporter signature motif; other site 455488009710 Walker B; other site 455488009711 D-loop; other site 455488009712 H-loop/switch region; other site 455488009713 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 455488009714 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488009715 FtsX-like permease family; Region: FtsX; pfam02687 455488009716 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488009717 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 455488009718 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 455488009719 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 455488009720 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 455488009721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009722 TPR motif; other site 455488009723 binding surface 455488009724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009725 binding surface 455488009726 TPR motif; other site 455488009727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009728 binding surface 455488009729 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488009730 TPR motif; other site 455488009731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488009732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 455488009733 Protein of unknown function, DUF482; Region: DUF482; pfam04339 455488009734 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 455488009735 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 455488009736 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 455488009737 maleylacetoacetate isomerase; Region: maiA; TIGR01262 455488009738 C-terminal domain interface [polypeptide binding]; other site 455488009739 GSH binding site (G-site) [chemical binding]; other site 455488009740 putative dimer interface [polypeptide binding]; other site 455488009741 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 455488009742 dimer interface [polypeptide binding]; other site 455488009743 N-terminal domain interface [polypeptide binding]; other site 455488009744 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 455488009745 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 455488009746 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 455488009747 dimer interface [polypeptide binding]; other site 455488009748 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 455488009749 active site 455488009750 Fe binding site [ion binding]; other site 455488009751 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 455488009752 alanine racemase; Reviewed; Region: alr; PRK00053 455488009753 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 455488009754 active site 455488009755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 455488009756 dimer interface [polypeptide binding]; other site 455488009757 substrate binding site [chemical binding]; other site 455488009758 catalytic residues [active] 455488009759 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 455488009760 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 455488009761 homodimer interface [polypeptide binding]; other site 455488009762 substrate-cofactor binding pocket; other site 455488009763 catalytic residue [active] 455488009764 MarR family; Region: MarR_2; pfam12802 455488009765 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 455488009766 active site 2 [active] 455488009767 active site 1 [active] 455488009768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 455488009769 motif 1; other site 455488009770 dimer interface [polypeptide binding]; other site 455488009771 active site 455488009772 motif 2; other site 455488009773 motif 3; other site 455488009774 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 455488009775 Amidase; Region: Amidase; cl11426 455488009776 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 455488009777 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 455488009778 TrkA-C domain; Region: TrkA_C; pfam02080 455488009779 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 455488009780 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 455488009781 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 455488009782 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 455488009783 active site 455488009784 Zn binding site [ion binding]; other site 455488009785 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 455488009786 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 455488009787 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 455488009788 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 455488009789 active site 455488009790 PHP Thumb interface [polypeptide binding]; other site 455488009791 metal binding site [ion binding]; metal-binding site 455488009792 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 455488009793 generic binding surface II; other site 455488009794 generic binding surface I; other site 455488009795 Predicted permeases [General function prediction only]; Region: COG0730 455488009796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488009797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 455488009798 DNA binding residues [nucleotide binding] 455488009799 dimerization interface [polypeptide binding]; other site 455488009800 threonine dehydratase; Provisional; Region: PRK08198 455488009801 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 455488009802 tetramer interface [polypeptide binding]; other site 455488009803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488009804 catalytic residue [active] 455488009805 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 455488009806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488009807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488009808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488009809 active site 455488009810 ATP binding site [chemical binding]; other site 455488009811 substrate binding site [chemical binding]; other site 455488009812 activation loop (A-loop); other site 455488009813 FOG: WD40 repeat [General function prediction only]; Region: COG2319 455488009814 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 455488009815 structural tetrad; other site 455488009816 PQQ-like domain; Region: PQQ_2; pfam13360 455488009817 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 455488009818 structural tetrad; other site 455488009819 FOG: WD40 repeat [General function prediction only]; Region: COG2319 455488009820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 455488009821 structural tetrad; other site 455488009822 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 455488009823 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 455488009824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488009825 catalytic residue [active] 455488009826 biotin synthase; Region: bioB; TIGR00433 455488009827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488009828 FeS/SAM binding site; other site 455488009829 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 455488009830 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 455488009831 DNA repair protein RadA; Provisional; Region: PRK11823 455488009832 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 455488009833 Walker A motif; other site 455488009834 ATP binding site [chemical binding]; other site 455488009835 Walker B motif; other site 455488009836 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 455488009837 glycerol kinase; Provisional; Region: glpK; PRK00047 455488009838 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 455488009839 N- and C-terminal domain interface [polypeptide binding]; other site 455488009840 active site 455488009841 MgATP binding site [chemical binding]; other site 455488009842 catalytic site [active] 455488009843 metal binding site [ion binding]; metal-binding site 455488009844 glycerol binding site [chemical binding]; other site 455488009845 homotetramer interface [polypeptide binding]; other site 455488009846 homodimer interface [polypeptide binding]; other site 455488009847 FBP binding site [chemical binding]; other site 455488009848 protein IIAGlc interface [polypeptide binding]; other site 455488009849 Esterase/lipase [General function prediction only]; Region: COG1647 455488009850 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 455488009851 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 455488009852 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 455488009853 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 455488009854 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 455488009855 PQQ-like domain; Region: PQQ_2; pfam13360 455488009856 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 455488009857 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 455488009858 intersubunit interface [polypeptide binding]; other site 455488009859 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 455488009860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 455488009861 dimer interface [polypeptide binding]; other site 455488009862 putative PBP binding regions; other site 455488009863 ABC-ATPase subunit interface; other site 455488009864 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 455488009865 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 455488009866 Walker A/P-loop; other site 455488009867 ATP binding site [chemical binding]; other site 455488009868 Q-loop/lid; other site 455488009869 ABC transporter signature motif; other site 455488009870 Walker B; other site 455488009871 D-loop; other site 455488009872 H-loop/switch region; other site 455488009873 Domain of unknown function (DUF222); Region: DUF222; pfam02720 455488009874 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488009875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488009876 active site 455488009877 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 455488009878 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 455488009879 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 455488009880 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 455488009881 active site 455488009882 tetramer interface; other site 455488009883 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488009884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009885 active site 455488009886 phosphorylation site [posttranslational modification] 455488009887 intermolecular recognition site; other site 455488009888 dimerization interface [polypeptide binding]; other site 455488009889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488009890 Walker A motif; other site 455488009891 ATP binding site [chemical binding]; other site 455488009892 Walker B motif; other site 455488009893 arginine finger; other site 455488009894 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488009895 Response regulator receiver domain; Region: Response_reg; pfam00072 455488009896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009897 active site 455488009898 phosphorylation site [posttranslational modification] 455488009899 intermolecular recognition site; other site 455488009900 dimerization interface [polypeptide binding]; other site 455488009901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488009902 dimer interface [polypeptide binding]; other site 455488009903 phosphorylation site [posttranslational modification] 455488009904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488009905 ATP binding site [chemical binding]; other site 455488009906 G-X-G motif; other site 455488009907 Response regulator receiver domain; Region: Response_reg; pfam00072 455488009908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488009909 active site 455488009910 phosphorylation site [posttranslational modification] 455488009911 intermolecular recognition site; other site 455488009912 dimerization interface [polypeptide binding]; other site 455488009913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488009914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488009915 metal binding site [ion binding]; metal-binding site 455488009916 active site 455488009917 I-site; other site 455488009918 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 455488009919 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 455488009920 pteridine reductase; Provisional; Region: PRK09135 455488009921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488009922 NAD(P) binding site [chemical binding]; other site 455488009923 active site 455488009924 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 455488009925 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 455488009926 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 455488009927 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 455488009928 NAD binding site [chemical binding]; other site 455488009929 homotetramer interface [polypeptide binding]; other site 455488009930 homodimer interface [polypeptide binding]; other site 455488009931 substrate binding site [chemical binding]; other site 455488009932 active site 455488009933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488009934 TPR motif; other site 455488009935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 455488009936 binding surface 455488009937 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 455488009938 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 455488009939 GTP binding site; other site 455488009940 camphor resistance protein CrcB; Provisional; Region: PRK14208 455488009941 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 455488009942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488009943 S-adenosylmethionine binding site [chemical binding]; other site 455488009944 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 455488009945 Pirin-related protein [General function prediction only]; Region: COG1741 455488009946 Pirin; Region: Pirin; pfam02678 455488009947 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 455488009948 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 455488009949 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 455488009950 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 455488009951 Transposase domain (DUF772); Region: DUF772; pfam05598 455488009952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488009953 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488009954 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 455488009955 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 455488009956 MPN+ (JAMM) motif; other site 455488009957 Zinc-binding site [ion binding]; other site 455488009958 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 455488009959 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 455488009960 ATP binding site [chemical binding]; other site 455488009961 substrate interface [chemical binding]; other site 455488009962 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 455488009963 active site residue [active] 455488009964 ThiS family; Region: ThiS; pfam02597 455488009965 charged pocket; other site 455488009966 hydrophobic patch; other site 455488009967 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 455488009968 putative homodimer interface [polypeptide binding]; other site 455488009969 putative homotetramer interface [polypeptide binding]; other site 455488009970 putative allosteric switch controlling residues; other site 455488009971 putative metal binding site [ion binding]; other site 455488009972 putative homodimer-homodimer interface [polypeptide binding]; other site 455488009973 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 455488009974 putative homodimer interface [polypeptide binding]; other site 455488009975 putative homotetramer interface [polypeptide binding]; other site 455488009976 putative allosteric switch controlling residues; other site 455488009977 putative metal binding site [ion binding]; other site 455488009978 putative homodimer-homodimer interface [polypeptide binding]; other site 455488009979 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 455488009980 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 455488009981 metal-binding site [ion binding] 455488009982 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 455488009983 Soluble P-type ATPase [General function prediction only]; Region: COG4087 455488009984 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 455488009985 SnoaL-like domain; Region: SnoaL_3; pfam13474 455488009986 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 455488009987 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488009988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488009989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 455488009990 Phosphoesterase family; Region: Phosphoesterase; pfam04185 455488009991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488009992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 455488009993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488009994 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488009995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 455488009996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 455488009997 active site 455488009998 catalytic tetrad [active] 455488009999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 455488010000 LysR family transcriptional regulator; Provisional; Region: PRK14997 455488010001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 455488010002 dimerization interface [polypeptide binding]; other site 455488010003 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 455488010004 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488010005 catalytic residues [active] 455488010006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 455488010007 putative lipid kinase; Reviewed; Region: PRK13057 455488010008 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 455488010009 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 455488010010 Hemerythrin-like domain; Region: Hr-like; cd12108 455488010011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 455488010012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488010013 dimer interface [polypeptide binding]; other site 455488010014 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 455488010015 putative CheW interface [polypeptide binding]; other site 455488010016 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 455488010017 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488010018 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488010019 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 455488010020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 455488010021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488010022 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 455488010023 IMP binding site; other site 455488010024 dimer interface [polypeptide binding]; other site 455488010025 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 455488010026 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 455488010027 active site residue [active] 455488010028 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 455488010029 active site residue [active] 455488010030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010031 Response regulator receiver domain; Region: Response_reg; pfam00072 455488010032 active site 455488010033 phosphorylation site [posttranslational modification] 455488010034 intermolecular recognition site; other site 455488010035 dimerization interface [polypeptide binding]; other site 455488010036 HEAT repeats; Region: HEAT_2; pfam13646 455488010037 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 455488010038 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 455488010039 DXD motif; other site 455488010040 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 455488010041 HflK protein; Region: hflK; TIGR01933 455488010042 HflC protein; Region: hflC; TIGR01932 455488010043 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 455488010044 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 455488010045 Predicted oxidoreductase [General function prediction only]; Region: COG3573 455488010046 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 455488010047 Peptidase family M48; Region: Peptidase_M48; cl12018 455488010048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 455488010049 non-specific DNA binding site [nucleotide binding]; other site 455488010050 salt bridge; other site 455488010051 sequence-specific DNA binding site [nucleotide binding]; other site 455488010052 HicB family; Region: HicB; pfam05534 455488010053 transposase/IS protein; Provisional; Region: PRK09183 455488010054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488010055 Walker A motif; other site 455488010056 ATP binding site [chemical binding]; other site 455488010057 Walker B motif; other site 455488010058 arginine finger; other site 455488010059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 455488010060 dimerization interface [polypeptide binding]; other site 455488010061 DNA binding residues [nucleotide binding] 455488010062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 455488010063 Integrase core domain; Region: rve; pfam00665 455488010064 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 455488010065 NTP binding site [chemical binding]; other site 455488010066 AAA domain; Region: AAA_14; pfam13173 455488010067 Double zinc ribbon; Region: DZR; pfam12773 455488010068 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 455488010069 Helix-turn-helix domain; Region: HTH_17; cl17695 455488010070 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 455488010071 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 455488010072 active site 455488010073 DNA binding site [nucleotide binding] 455488010074 Int/Topo IB signature motif; other site 455488010075 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 455488010076 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 455488010077 putative active site [active] 455488010078 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 455488010079 TPR repeat; Region: TPR_11; pfam13414 455488010080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488010081 TPR motif; other site 455488010082 binding surface 455488010083 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488010084 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 455488010085 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 455488010086 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488010087 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488010088 catalytic residue [active] 455488010089 L-aspartate oxidase; Provisional; Region: PRK06175 455488010090 L-aspartate oxidase; Provisional; Region: PRK09077 455488010091 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 455488010092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488010093 active site 455488010094 ParB-like nuclease domain; Region: ParBc; cl02129 455488010095 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 455488010096 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 455488010097 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 455488010098 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488010099 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 455488010100 DNA binding residues [nucleotide binding] 455488010101 nitrilase; Region: PLN02798 455488010102 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 455488010103 putative active site [active] 455488010104 catalytic triad [active] 455488010105 dimer interface [polypeptide binding]; other site 455488010106 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 455488010107 Interdomain contacts; other site 455488010108 Cytokine receptor motif; other site 455488010109 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 455488010110 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 455488010111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488010112 TIGR01777 family protein; Region: yfcH 455488010113 NAD(P) binding site [chemical binding]; other site 455488010114 active site 455488010115 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 455488010116 Peptidase family M50; Region: Peptidase_M50; pfam02163 455488010117 active site 455488010118 putative substrate binding region [chemical binding]; other site 455488010119 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 455488010120 Glycoprotease family; Region: Peptidase_M22; pfam00814 455488010121 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 455488010122 active site 455488010123 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 455488010124 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 455488010125 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 455488010126 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 455488010127 putative substrate binding region [chemical binding]; other site 455488010128 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 455488010129 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 455488010130 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 455488010131 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 455488010132 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 455488010133 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 455488010134 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 455488010135 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 455488010136 catalytic residue [active] 455488010137 putative FPP diphosphate binding site; other site 455488010138 putative FPP binding hydrophobic cleft; other site 455488010139 dimer interface [polypeptide binding]; other site 455488010140 putative IPP diphosphate binding site; other site 455488010141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488010142 active site 455488010143 ATP binding site [chemical binding]; other site 455488010144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488010145 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 455488010146 substrate binding site [chemical binding]; other site 455488010147 activation loop (A-loop); other site 455488010148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488010149 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488010150 Walker A motif; other site 455488010151 ATP binding site [chemical binding]; other site 455488010152 Walker B motif; other site 455488010153 aspartate kinase; Reviewed; Region: PRK06635 455488010154 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 455488010155 putative nucleotide binding site [chemical binding]; other site 455488010156 putative catalytic residues [active] 455488010157 putative Mg ion binding site [ion binding]; other site 455488010158 putative aspartate binding site [chemical binding]; other site 455488010159 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 455488010160 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 455488010161 oligomerisation interface [polypeptide binding]; other site 455488010162 mobile loop; other site 455488010163 roof hairpin; other site 455488010164 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 455488010165 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 455488010166 ring oligomerisation interface [polypeptide binding]; other site 455488010167 ATP/Mg binding site [chemical binding]; other site 455488010168 stacking interactions; other site 455488010169 hinge regions; other site 455488010170 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488010171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488010172 TPR motif; other site 455488010173 binding surface 455488010174 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 455488010175 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 455488010176 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 455488010177 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 455488010178 Spore Coat Protein U domain; Region: SCPU; pfam05229 455488010179 Spore Coat Protein U domain; Region: SCPU; pfam05229 455488010180 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 455488010181 active site 455488010182 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 455488010183 amphipathic channel; other site 455488010184 Asn-Pro-Ala signature motifs; other site 455488010185 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 455488010186 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 455488010187 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488010188 active site 455488010189 Family description; Region: VCBS; pfam13517 455488010190 Family description; Region: VCBS; pfam13517 455488010191 Family description; Region: VCBS; pfam13517 455488010192 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 455488010193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 455488010194 minor groove reading motif; other site 455488010195 helix-hairpin-helix signature motif; other site 455488010196 substrate binding pocket [chemical binding]; other site 455488010197 active site 455488010198 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 455488010199 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 455488010200 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 455488010201 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 455488010202 tetramer interfaces [polypeptide binding]; other site 455488010203 binuclear metal-binding site [ion binding]; other site 455488010204 competence damage-inducible protein A; Provisional; Region: PRK00549 455488010205 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 455488010206 putative MPT binding site; other site 455488010207 Competence-damaged protein; Region: CinA; pfam02464 455488010208 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 455488010209 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488010210 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 455488010211 Surface antigen; Region: Bac_surface_Ag; pfam01103 455488010212 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 455488010213 hexamer interface [polypeptide binding]; other site 455488010214 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488010215 Walker A motif; other site 455488010216 ATP binding site [chemical binding]; other site 455488010217 Walker B motif; other site 455488010218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 455488010219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 455488010220 catalytic residues [active] 455488010221 catalytic nucleophile [active] 455488010222 Recombinase; Region: Recombinase; pfam07508 455488010223 Beta protein; Region: Beta_protein; pfam14350 455488010224 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488010225 active site 455488010226 DNA methylase; Region: N6_N4_Mtase; cl17433 455488010227 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 455488010228 DNA methylase; Region: N6_N4_Mtase; pfam01555 455488010229 Restriction endonuclease; Region: Mrr_cat; pfam04471 455488010230 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 455488010231 Fe-S cluster binding site [ion binding]; other site 455488010232 DNA binding site [nucleotide binding] 455488010233 active site 455488010234 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 455488010235 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 455488010236 G1 box; other site 455488010237 GTP/Mg2+ binding site [chemical binding]; other site 455488010238 G2 box; other site 455488010239 Switch I region; other site 455488010240 G3 box; other site 455488010241 Switch II region; other site 455488010242 G4 box; other site 455488010243 G5 box; other site 455488010244 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 455488010245 recombination protein RecR; Reviewed; Region: recR; PRK00076 455488010246 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 455488010247 RecR protein; Region: RecR; pfam02132 455488010248 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 455488010249 putative active site [active] 455488010250 putative metal-binding site [ion binding]; other site 455488010251 tetramer interface [polypeptide binding]; other site 455488010252 hypothetical protein; Provisional; Region: PRK14622 455488010253 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 455488010254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488010255 Walker A motif; other site 455488010256 ATP binding site [chemical binding]; other site 455488010257 Walker B motif; other site 455488010258 arginine finger; other site 455488010259 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 455488010260 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 455488010261 nucleoside/Zn binding site; other site 455488010262 dimer interface [polypeptide binding]; other site 455488010263 catalytic motif [active] 455488010264 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 455488010265 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 455488010266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488010267 FeS/SAM binding site; other site 455488010268 Thioredoxin; Region: Thioredoxin_4; pfam13462 455488010269 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488010270 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488010271 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 455488010272 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 455488010273 Permutation of conserved domain; other site 455488010274 active site 455488010275 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 455488010276 GAF domain; Region: GAF; cl17456 455488010277 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 455488010278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488010279 ligand binding site [chemical binding]; other site 455488010280 Predicted membrane protein [Function unknown]; Region: COG2261 455488010281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488010282 TPR repeat; Region: TPR_11; pfam13414 455488010283 binding surface 455488010284 TPR motif; other site 455488010285 PEGA domain; Region: PEGA; pfam08308 455488010286 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488010287 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488010288 active site 455488010289 ATP binding site [chemical binding]; other site 455488010290 substrate binding site [chemical binding]; other site 455488010291 activation loop (A-loop); other site 455488010292 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488010293 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488010294 phosphopeptide binding site; other site 455488010295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488010296 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 455488010297 Walker A motif; other site 455488010298 ATP binding site [chemical binding]; other site 455488010299 Walker B motif; other site 455488010300 arginine finger; other site 455488010301 Helix-turn-helix domain; Region: HTH_17; pfam12728 455488010302 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 455488010303 active site 455488010304 phosphorylation site [posttranslational modification] 455488010305 hydrogenase 4 subunit B; Validated; Region: PRK06521 455488010306 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488010307 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488010308 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 455488010309 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 455488010310 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 455488010311 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 455488010312 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 455488010313 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 455488010314 4Fe-4S binding domain; Region: Fer4; pfam00037 455488010315 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 455488010316 PspC domain; Region: PspC; pfam04024 455488010317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488010318 S-adenosylmethionine binding site [chemical binding]; other site 455488010319 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 455488010320 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 455488010321 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 455488010322 active site 455488010323 aconitate hydratase; Validated; Region: PRK09277 455488010324 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 455488010325 substrate binding site [chemical binding]; other site 455488010326 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 455488010327 ligand binding site [chemical binding]; other site 455488010328 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 455488010329 substrate binding site [chemical binding]; other site 455488010330 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 455488010331 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 455488010332 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 455488010333 type I citrate synthase; Reviewed; Region: PRK09569 455488010334 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 455488010335 oxalacetate binding site [chemical binding]; other site 455488010336 citrylCoA binding site [chemical binding]; other site 455488010337 coenzyme A binding site [chemical binding]; other site 455488010338 catalytic triad [active] 455488010339 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 455488010340 Peptidase family M23; Region: Peptidase_M23; pfam01551 455488010341 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 455488010342 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 455488010343 RNA binding site [nucleotide binding]; other site 455488010344 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 455488010345 RNA binding site [nucleotide binding]; other site 455488010346 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 455488010347 RNA binding site [nucleotide binding]; other site 455488010348 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 455488010349 RNA binding site [nucleotide binding]; other site 455488010350 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 455488010351 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 455488010352 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 455488010353 catalytic site [active] 455488010354 active site 455488010355 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 455488010356 active site 455488010357 substrate-binding site [chemical binding]; other site 455488010358 metal-binding site [ion binding] 455488010359 GTP binding site [chemical binding]; other site 455488010360 NRDE protein; Region: NRDE; cl01315 455488010361 Protein of unknown function (DUF971); Region: DUF971; pfam06155 455488010362 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 455488010363 SmpB-tmRNA interface; other site 455488010364 Pantoate-beta-alanine ligase; Region: PanC; cd00560 455488010365 pantoate--beta-alanine ligase; Region: panC; TIGR00018 455488010366 active site 455488010367 ATP-binding site [chemical binding]; other site 455488010368 pantoate-binding site; other site 455488010369 HXXH motif; other site 455488010370 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 455488010371 oligomerization interface [polypeptide binding]; other site 455488010372 active site 455488010373 metal binding site [ion binding]; metal-binding site 455488010374 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 455488010375 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 455488010376 Substrate-binding site [chemical binding]; other site 455488010377 Substrate specificity [chemical binding]; other site 455488010378 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 455488010379 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 455488010380 UGMP family protein; Validated; Region: PRK09604 455488010381 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 455488010382 Response regulator receiver domain; Region: Response_reg; pfam00072 455488010383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010384 active site 455488010385 phosphorylation site [posttranslational modification] 455488010386 intermolecular recognition site; other site 455488010387 dimerization interface [polypeptide binding]; other site 455488010388 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488010389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488010390 TPR repeat; Region: TPR_11; pfam13414 455488010391 TPR motif; other site 455488010392 binding surface 455488010393 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488010394 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488010395 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488010396 HSP70 interaction site [polypeptide binding]; other site 455488010397 Protein phosphatase 2C; Region: PP2C; pfam00481 455488010398 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 455488010399 active site 455488010400 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 455488010401 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 455488010402 Substrate binding site; other site 455488010403 metal-binding site 455488010404 MFS_1 like family; Region: MFS_1_like; pfam12832 455488010405 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 455488010406 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 455488010407 active site 455488010408 catalytic site [active] 455488010409 substrate binding site [chemical binding]; other site 455488010410 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 455488010411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488010412 ligand binding site [chemical binding]; other site 455488010413 flexible hinge region; other site 455488010414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 455488010415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 455488010416 metal binding triad; other site 455488010417 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 455488010418 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 455488010419 Na binding site [ion binding]; other site 455488010420 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 455488010421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488010422 putative substrate translocation pore; other site 455488010423 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488010424 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488010425 active site 455488010426 ATP binding site [chemical binding]; other site 455488010427 substrate binding site [chemical binding]; other site 455488010428 activation loop (A-loop); other site 455488010429 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 455488010430 Ligand Binding Site [chemical binding]; other site 455488010431 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 455488010432 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488010433 active site 455488010434 metal binding site [ion binding]; metal-binding site 455488010435 Protein of unknown function, DUF485; Region: DUF485; pfam04341 455488010436 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 455488010437 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 455488010438 Na binding site [ion binding]; other site 455488010439 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 455488010440 HAMP domain; Region: HAMP; pfam00672 455488010441 dimerization interface [polypeptide binding]; other site 455488010442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488010443 dimer interface [polypeptide binding]; other site 455488010444 putative CheW interface [polypeptide binding]; other site 455488010445 Phosphotransferase enzyme family; Region: APH; pfam01636 455488010446 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 455488010447 active site 455488010448 ATP binding site [chemical binding]; other site 455488010449 substrate binding site [chemical binding]; other site 455488010450 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 455488010451 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 455488010452 dimer interface [polypeptide binding]; other site 455488010453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488010454 catalytic residue [active] 455488010455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 455488010456 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 455488010457 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 455488010458 homodimer interface [polypeptide binding]; other site 455488010459 substrate-cofactor binding pocket; other site 455488010460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488010461 catalytic residue [active] 455488010462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488010463 putative substrate translocation pore; other site 455488010464 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 455488010465 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 455488010466 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 455488010467 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 455488010468 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 455488010469 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 455488010470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488010471 dimer interface [polypeptide binding]; other site 455488010472 putative CheW interface [polypeptide binding]; other site 455488010473 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 455488010474 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 455488010475 active site 455488010476 FMN binding site [chemical binding]; other site 455488010477 substrate binding site [chemical binding]; other site 455488010478 homotetramer interface [polypeptide binding]; other site 455488010479 catalytic residue [active] 455488010480 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 455488010481 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 455488010482 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 455488010483 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 455488010484 putative RNA binding site [nucleotide binding]; other site 455488010485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488010486 S-adenosylmethionine binding site [chemical binding]; other site 455488010487 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 455488010488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 455488010489 ligand binding site [chemical binding]; other site 455488010490 flexible hinge region; other site 455488010491 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 455488010492 active site 455488010493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488010494 PAS domain; Region: PAS_9; pfam13426 455488010495 putative active site [active] 455488010496 heme pocket [chemical binding]; other site 455488010497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 455488010498 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 455488010499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488010500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488010501 ATP binding site [chemical binding]; other site 455488010502 Mg2+ binding site [ion binding]; other site 455488010503 G-X-G motif; other site 455488010504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488010505 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 455488010506 Transposase domain (DUF772); Region: DUF772; pfam05598 455488010507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488010508 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488010509 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 455488010510 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 455488010511 motif 1; other site 455488010512 dimer interface [polypeptide binding]; other site 455488010513 active site 455488010514 motif 2; other site 455488010515 motif 3; other site 455488010516 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 455488010517 Zn binding site [ion binding]; other site 455488010518 PAS domain; Region: PAS_9; pfam13426 455488010519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488010520 putative active site [active] 455488010521 heme pocket [chemical binding]; other site 455488010522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488010523 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 455488010524 putative active site [active] 455488010525 heme pocket [chemical binding]; other site 455488010526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488010527 dimer interface [polypeptide binding]; other site 455488010528 phosphorylation site [posttranslational modification] 455488010529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488010530 ATP binding site [chemical binding]; other site 455488010531 Mg2+ binding site [ion binding]; other site 455488010532 G-X-G motif; other site 455488010533 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488010534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010535 active site 455488010536 phosphorylation site [posttranslational modification] 455488010537 intermolecular recognition site; other site 455488010538 dimerization interface [polypeptide binding]; other site 455488010539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488010540 Walker A motif; other site 455488010541 ATP binding site [chemical binding]; other site 455488010542 Walker B motif; other site 455488010543 arginine finger; other site 455488010544 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488010545 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 455488010546 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 455488010547 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 455488010548 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 455488010549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 455488010550 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 455488010551 TAP-like protein; Region: Abhydrolase_4; pfam08386 455488010552 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 455488010553 Methyltransferase domain; Region: Methyltransf_11; pfam08241 455488010554 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 455488010555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488010556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488010557 DNA binding residues [nucleotide binding] 455488010558 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 455488010559 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 455488010560 glycogen binding site [chemical binding]; other site 455488010561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488010562 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488010563 active site 455488010564 ATP binding site [chemical binding]; other site 455488010565 substrate binding site [chemical binding]; other site 455488010566 activation loop (A-loop); other site 455488010567 PEGA domain; Region: PEGA; pfam08308 455488010568 PEGA domain; Region: PEGA; pfam08308 455488010569 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 455488010570 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 455488010571 phosphopeptide binding site; other site 455488010572 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 455488010573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 455488010574 substrate binding site [chemical binding]; other site 455488010575 oxyanion hole (OAH) forming residues; other site 455488010576 trimer interface [polypeptide binding]; other site 455488010577 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 455488010578 carboxyltransferase (CT) interaction site; other site 455488010579 biotinylation site [posttranslational modification]; other site 455488010580 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 455488010581 CoenzymeA binding site [chemical binding]; other site 455488010582 subunit interaction site [polypeptide binding]; other site 455488010583 PHB binding site; other site 455488010584 PilZ domain; Region: PilZ; cl01260 455488010585 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488010586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010587 active site 455488010588 phosphorylation site [posttranslational modification] 455488010589 intermolecular recognition site; other site 455488010590 dimerization interface [polypeptide binding]; other site 455488010591 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 455488010592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488010593 NAD(P) binding site [chemical binding]; other site 455488010594 active site 455488010595 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 455488010596 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 455488010597 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488010598 ligand binding site [chemical binding]; other site 455488010599 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 455488010600 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 455488010601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488010602 catalytic residue [active] 455488010603 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 455488010604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 455488010605 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 455488010606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488010607 putative PBP binding loops; other site 455488010608 dimer interface [polypeptide binding]; other site 455488010609 ABC-ATPase subunit interface; other site 455488010610 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 455488010611 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 455488010612 Walker A/P-loop; other site 455488010613 ATP binding site [chemical binding]; other site 455488010614 Q-loop/lid; other site 455488010615 ABC transporter signature motif; other site 455488010616 Walker B; other site 455488010617 D-loop; other site 455488010618 H-loop/switch region; other site 455488010619 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 455488010620 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 455488010621 [4Fe-4S] binding site [ion binding]; other site 455488010622 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488010623 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 455488010624 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 455488010625 molybdopterin cofactor binding site; other site 455488010626 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 455488010627 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 455488010628 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 455488010629 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 455488010630 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 455488010631 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 455488010632 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 455488010633 short chain dehydrogenase; Provisional; Region: PRK08278 455488010634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488010635 NAD(P) binding site [chemical binding]; other site 455488010636 active site 455488010637 cell division protein MraZ; Reviewed; Region: PRK00326 455488010638 MraZ protein; Region: MraZ; pfam02381 455488010639 MraZ protein; Region: MraZ; pfam02381 455488010640 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 455488010641 MraW methylase family; Region: Methyltransf_5; cl17771 455488010642 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 455488010643 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 455488010644 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 455488010645 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 455488010646 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 455488010647 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 455488010648 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 455488010649 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 455488010650 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 455488010651 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 455488010652 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 455488010653 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 455488010654 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 455488010655 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 455488010656 Mg++ binding site [ion binding]; other site 455488010657 putative catalytic motif [active] 455488010658 putative substrate binding site [chemical binding]; other site 455488010659 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 455488010660 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 455488010661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 455488010662 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 455488010663 cell division protein FtsW; Region: ftsW; TIGR02614 455488010664 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 455488010665 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 455488010666 active site 455488010667 homodimer interface [polypeptide binding]; other site 455488010668 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 455488010669 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 455488010670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 455488010671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 455488010672 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 455488010673 FAD binding domain; Region: FAD_binding_4; pfam01565 455488010674 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 455488010675 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 455488010676 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 455488010677 ATP-grasp domain; Region: ATP-grasp_4; cl17255 455488010678 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488010679 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488010680 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488010681 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 455488010682 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 455488010683 Cell division protein FtsQ; Region: FtsQ; pfam03799 455488010684 cell division protein FtsA; Region: ftsA; TIGR01174 455488010685 Cell division protein FtsA; Region: FtsA; smart00842 455488010686 Cell division protein FtsA; Region: FtsA; pfam14450 455488010687 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 455488010688 cell division protein FtsZ; Validated; Region: PRK09330 455488010689 nucleotide binding site [chemical binding]; other site 455488010690 SulA interaction site; other site 455488010691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 455488010692 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 455488010693 putative hydrophobic ligand binding site [chemical binding]; other site 455488010694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488010695 dimerization interface [polypeptide binding]; other site 455488010696 putative DNA binding site [nucleotide binding]; other site 455488010697 putative Zn2+ binding site [ion binding]; other site 455488010698 Putative esterase; Region: Esterase; pfam00756 455488010699 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 455488010700 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 455488010701 motif 1; other site 455488010702 active site 455488010703 motif 2; other site 455488010704 motif 3; other site 455488010705 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 455488010706 DHHA1 domain; Region: DHHA1; pfam02272 455488010707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488010708 S-adenosylmethionine binding site [chemical binding]; other site 455488010709 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488010710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488010711 Walker A/P-loop; other site 455488010712 ATP binding site [chemical binding]; other site 455488010713 Q-loop/lid; other site 455488010714 ABC transporter signature motif; other site 455488010715 Walker B; other site 455488010716 D-loop; other site 455488010717 H-loop/switch region; other site 455488010718 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 455488010719 N-acetyl-D-glucosamine binding site [chemical binding]; other site 455488010720 catalytic residue [active] 455488010721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488010722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 455488010723 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 455488010724 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 455488010725 FMN binding site [chemical binding]; other site 455488010726 active site 455488010727 catalytic residues [active] 455488010728 substrate binding site [chemical binding]; other site 455488010729 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 455488010730 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 455488010731 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 455488010732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 455488010733 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 455488010734 DNA binding residues [nucleotide binding] 455488010735 dimerization interface [polypeptide binding]; other site 455488010736 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 455488010737 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 455488010738 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 455488010739 protein binding site [polypeptide binding]; other site 455488010740 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 455488010741 Catalytic dyad [active] 455488010742 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 455488010743 Ligand Binding Site [chemical binding]; other site 455488010744 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 455488010745 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 455488010746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488010747 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 455488010748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 455488010749 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 455488010750 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 455488010751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 455488010752 metal binding site 2 [ion binding]; metal-binding site 455488010753 putative DNA binding helix; other site 455488010754 metal binding site 1 [ion binding]; metal-binding site 455488010755 dimer interface [polypeptide binding]; other site 455488010756 structural Zn2+ binding site [ion binding]; other site 455488010757 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 455488010758 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 455488010759 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 455488010760 dimer interface [polypeptide binding]; other site 455488010761 ssDNA binding site [nucleotide binding]; other site 455488010762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 455488010763 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 455488010764 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 455488010765 GIY-YIG motif/motif A; other site 455488010766 putative active site [active] 455488010767 putative metal binding site [ion binding]; other site 455488010768 TPR repeat; Region: TPR_11; pfam13414 455488010769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488010770 binding surface 455488010771 TPR motif; other site 455488010772 Tetratricopeptide repeat; Region: TPR_16; pfam13432 455488010773 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 455488010774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 455488010775 motif II; other site 455488010776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 455488010777 putative DNA binding site [nucleotide binding]; other site 455488010778 putative Zn2+ binding site [ion binding]; other site 455488010779 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 455488010780 putative hydrophobic ligand binding site [chemical binding]; other site 455488010781 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 455488010782 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 455488010783 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 455488010784 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 455488010785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 455488010786 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 455488010787 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 455488010788 active site 455488010789 dimer interface [polypeptide binding]; other site 455488010790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 455488010791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 455488010792 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 455488010793 hypothetical protein; Reviewed; Region: PRK00024 455488010794 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 455488010795 MPN+ (JAMM) motif; other site 455488010796 Zinc-binding site [ion binding]; other site 455488010797 Peptidase family C69; Region: Peptidase_C69; cl17793 455488010798 Uncharacterized conserved protein [Function unknown]; Region: COG2353 455488010799 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 455488010800 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 455488010801 metal binding site [ion binding]; metal-binding site 455488010802 putative dimer interface [polypeptide binding]; other site 455488010803 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 455488010804 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 455488010805 trimer interface [polypeptide binding]; other site 455488010806 active site 455488010807 substrate binding site [chemical binding]; other site 455488010808 CoA binding site [chemical binding]; other site 455488010809 succinyldiaminopimelate transaminase; Region: DapC; TIGR03537 455488010810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488010811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488010812 homodimer interface [polypeptide binding]; other site 455488010813 catalytic residue [active] 455488010814 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 455488010815 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 455488010816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488010817 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 455488010818 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 455488010819 glutathione s-transferase; Provisional; Region: PTZ00057 455488010820 GSH binding site (G-site) [chemical binding]; other site 455488010821 C-terminal domain interface [polypeptide binding]; other site 455488010822 dimer interface [polypeptide binding]; other site 455488010823 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 455488010824 dimer interface [polypeptide binding]; other site 455488010825 N-terminal domain interface [polypeptide binding]; other site 455488010826 substrate binding pocket (H-site) [chemical binding]; other site 455488010827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 455488010828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 455488010829 P-loop; other site 455488010830 Magnesium ion binding site [ion binding]; other site 455488010831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 455488010832 Magnesium ion binding site [ion binding]; other site 455488010833 HEAT repeats; Region: HEAT_2; pfam13646 455488010834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488010835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488010836 putative substrate translocation pore; other site 455488010837 FOG: CBS domain [General function prediction only]; Region: COG0517 455488010838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 455488010839 Transporter associated domain; Region: CorC_HlyC; smart01091 455488010840 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 455488010841 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 455488010842 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 455488010843 putative active site [active] 455488010844 catalytic triad [active] 455488010845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 455488010846 Response regulator receiver domain; Region: Response_reg; pfam00072 455488010847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010848 active site 455488010849 phosphorylation site [posttranslational modification] 455488010850 intermolecular recognition site; other site 455488010851 dimerization interface [polypeptide binding]; other site 455488010852 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 455488010853 protease TldD; Provisional; Region: tldD; PRK10735 455488010854 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 455488010855 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 455488010856 classical (c) SDRs; Region: SDR_c; cd05233 455488010857 NAD(P) binding site [chemical binding]; other site 455488010858 active site 455488010859 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 455488010860 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 455488010861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488010862 seryl-tRNA synthetase; Provisional; Region: PRK05431 455488010863 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 455488010864 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 455488010865 dimer interface [polypeptide binding]; other site 455488010866 active site 455488010867 motif 1; other site 455488010868 motif 2; other site 455488010869 motif 3; other site 455488010870 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 455488010871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488010872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488010873 dimer interface [polypeptide binding]; other site 455488010874 phosphorylation site [posttranslational modification] 455488010875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488010876 ATP binding site [chemical binding]; other site 455488010877 Mg2+ binding site [ion binding]; other site 455488010878 G-X-G motif; other site 455488010879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488010880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010881 active site 455488010882 phosphorylation site [posttranslational modification] 455488010883 intermolecular recognition site; other site 455488010884 dimerization interface [polypeptide binding]; other site 455488010885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488010886 DNA binding site [nucleotide binding] 455488010887 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 455488010888 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488010889 Outer membrane efflux protein; Region: OEP; pfam02321 455488010890 DNA methylase; Region: N6_N4_Mtase; pfam01555 455488010891 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 455488010892 DNA methylase; Region: N6_N4_Mtase; pfam01555 455488010893 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 455488010894 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 455488010895 putative transposase OrfB; Reviewed; Region: PHA02517 455488010896 HTH-like domain; Region: HTH_21; pfam13276 455488010897 Integrase core domain; Region: rve; pfam00665 455488010898 Integrase core domain; Region: rve_3; pfam13683 455488010899 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 455488010900 DNA-binding interface [nucleotide binding]; DNA binding site 455488010901 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 455488010902 DGQHR domain; Region: DGQHR; TIGR03187 455488010903 HNH endonuclease; Region: HNH_2; pfam13391 455488010904 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 455488010905 PLD-like domain; Region: PLDc_2; pfam13091 455488010906 putative homodimer interface [polypeptide binding]; other site 455488010907 putative active site [active] 455488010908 catalytic site [active] 455488010909 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 455488010910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488010911 ATP binding site [chemical binding]; other site 455488010912 putative Mg++ binding site [ion binding]; other site 455488010913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488010914 nucleotide binding region [chemical binding]; other site 455488010915 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 455488010916 Predicted transcriptional regulator [Transcription]; Region: COG4189 455488010917 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 455488010918 SnoaL-like domain; Region: SnoaL_2; pfam12680 455488010919 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 455488010920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488010921 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 455488010922 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 455488010923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488010924 ATP binding site [chemical binding]; other site 455488010925 putative Mg++ binding site [ion binding]; other site 455488010926 helicase superfamily c-terminal domain; Region: HELICc; smart00490 455488010927 nucleotide binding region [chemical binding]; other site 455488010928 ATP-binding site [chemical binding]; other site 455488010929 DEAD/H associated; Region: DEAD_assoc; pfam08494 455488010930 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 455488010931 Family description; Region: UvrD_C_2; pfam13538 455488010932 SEC-C motif; Region: SEC-C; pfam02810 455488010933 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 455488010934 HD domain; Region: HD_4; pfam13328 455488010935 OsmC-like protein; Region: OsmC; pfam02566 455488010936 B12 binding domain; Region: B12-binding; pfam02310 455488010937 B12 binding site [chemical binding]; other site 455488010938 Radical SAM superfamily; Region: Radical_SAM; pfam04055 455488010939 hypothetical protein; Provisional; Region: PRK07546 455488010940 substrate-cofactor binding pocket; other site 455488010941 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 455488010942 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 455488010943 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 455488010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488010945 phosphorylation site [posttranslational modification] 455488010946 intermolecular recognition site; other site 455488010947 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 455488010948 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 455488010949 active site 455488010950 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 455488010951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488010952 dimerization interface [polypeptide binding]; other site 455488010953 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488010954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488010955 dimer interface [polypeptide binding]; other site 455488010956 putative CheW interface [polypeptide binding]; other site 455488010957 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 455488010958 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 455488010959 active site 455488010960 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 455488010961 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 455488010962 active site 455488010963 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 455488010964 putative NADP binding site [chemical binding]; other site 455488010965 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 455488010966 active site 455488010967 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 455488010968 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 455488010969 active site 455488010970 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 455488010971 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 455488010972 active site 455488010973 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 455488010974 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 455488010975 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 455488010976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488010977 HTH domain; Region: HTH_11; pfam08279 455488010978 WYL domain; Region: WYL; pfam13280 455488010979 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 455488010980 active site 455488010981 Methyltransferase domain; Region: Methyltransf_31; pfam13847 455488010982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488010983 S-adenosylmethionine binding site [chemical binding]; other site 455488010984 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 455488010985 putative catalytic residues [active] 455488010986 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 455488010987 propionate/acetate kinase; Provisional; Region: PRK12379 455488010988 Uncharacterized conserved protein [Function unknown]; Region: COG3791 455488010989 RibD C-terminal domain; Region: RibD_C; cl17279 455488010990 RibD C-terminal domain; Region: RibD_C; cl17279 455488010991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488010992 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 455488010993 Walker A/P-loop; other site 455488010994 ATP binding site [chemical binding]; other site 455488010995 Q-loop/lid; other site 455488010996 ABC transporter signature motif; other site 455488010997 Walker B; other site 455488010998 D-loop; other site 455488010999 H-loop/switch region; other site 455488011000 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 455488011001 ABC-2 type transporter; Region: ABC2_membrane; cl17235 455488011002 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 455488011003 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 455488011004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488011005 Walker A/P-loop; other site 455488011006 ATP binding site [chemical binding]; other site 455488011007 Q-loop/lid; other site 455488011008 ABC transporter signature motif; other site 455488011009 Walker B; other site 455488011010 D-loop; other site 455488011011 H-loop/switch region; other site 455488011012 ABC transporter; Region: ABC_tran_2; pfam12848 455488011013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488011014 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 455488011015 putative dimer interface [polypeptide binding]; other site 455488011016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488011017 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 455488011018 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 455488011019 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 455488011020 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 455488011021 benzoate transport; Region: 2A0115; TIGR00895 455488011022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011023 putative substrate translocation pore; other site 455488011024 RmuC family; Region: RmuC; pfam02646 455488011025 Predicted transcriptional regulator [Transcription]; Region: COG2378 455488011026 WYL domain; Region: WYL; pfam13280 455488011027 WYL domain; Region: WYL; pfam13280 455488011028 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488011029 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 455488011030 putative acyl-acceptor binding pocket; other site 455488011031 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 455488011032 Amidase; Region: Amidase; cl11426 455488011033 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 455488011034 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 455488011035 putative DNA binding site [nucleotide binding]; other site 455488011036 catalytic residue [active] 455488011037 putative H2TH interface [polypeptide binding]; other site 455488011038 putative catalytic residues [active] 455488011039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 455488011040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 455488011041 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 455488011042 Malic enzyme, N-terminal domain; Region: malic; pfam00390 455488011043 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 455488011044 putative NAD(P) binding site [chemical binding]; other site 455488011045 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 455488011046 homoserine dehydrogenase; Provisional; Region: PRK06270 455488011047 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 455488011048 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 455488011049 Domain of unknown function DUF302; Region: DUF302; pfam03625 455488011050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488011051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 455488011052 Domain of unknown function (DUF222); Region: DUF222; pfam02720 455488011053 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488011054 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011055 active site 455488011056 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 455488011057 FtsX-like permease family; Region: FtsX; pfam02687 455488011058 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 455488011059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488011060 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488011061 Walker A/P-loop; other site 455488011062 ATP binding site [chemical binding]; other site 455488011063 Q-loop/lid; other site 455488011064 ABC transporter signature motif; other site 455488011065 Walker B; other site 455488011066 D-loop; other site 455488011067 H-loop/switch region; other site 455488011068 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 455488011069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 455488011070 Smr domain; Region: Smr; pfam01713 455488011071 Outer membrane efflux protein; Region: OEP; pfam02321 455488011072 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488011073 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488011074 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 455488011075 Protein export membrane protein; Region: SecD_SecF; cl14618 455488011076 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 455488011077 MgtE intracellular N domain; Region: MgtE_N; smart00924 455488011078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 455488011079 Divalent cation transporter; Region: MgtE; pfam01769 455488011080 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 455488011081 active site 455488011082 dimer interface [polypeptide binding]; other site 455488011083 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488011084 prolyl-tRNA synthetase; Provisional; Region: PRK09194 455488011085 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 455488011086 dimer interface [polypeptide binding]; other site 455488011087 motif 1; other site 455488011088 active site 455488011089 motif 2; other site 455488011090 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 455488011091 putative deacylase active site [active] 455488011092 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 455488011093 active site 455488011094 motif 3; other site 455488011095 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 455488011096 anticodon binding site; other site 455488011097 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 455488011098 GcpE protein; Region: GcpE; pfam04551 455488011099 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 455488011100 Thioredoxin; Region: Thioredoxin_4; pfam13462 455488011101 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488011102 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 455488011103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 455488011104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 455488011105 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 455488011106 trimer interface [polypeptide binding]; other site 455488011107 dimer interface [polypeptide binding]; other site 455488011108 putative active site [active] 455488011109 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 455488011110 CheW-like domain; Region: CheW; pfam01584 455488011111 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 455488011112 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 455488011113 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 455488011114 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 455488011115 Substrate binding site; other site 455488011116 Mg++ binding site; other site 455488011117 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 455488011118 active site 455488011119 substrate binding site [chemical binding]; other site 455488011120 CoA binding site [chemical binding]; other site 455488011121 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 455488011122 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 455488011123 glutaminase active site [active] 455488011124 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 455488011125 dimer interface [polypeptide binding]; other site 455488011126 active site 455488011127 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 455488011128 dimer interface [polypeptide binding]; other site 455488011129 active site 455488011130 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 455488011131 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 455488011132 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 455488011133 recombinase A; Provisional; Region: recA; PRK09354 455488011134 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 455488011135 hexamer interface [polypeptide binding]; other site 455488011136 Walker A motif; other site 455488011137 ATP binding site [chemical binding]; other site 455488011138 Walker B motif; other site 455488011139 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 455488011140 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 455488011141 MOFRL family; Region: MOFRL; pfam05161 455488011142 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 455488011143 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 455488011144 putative active site [active] 455488011145 substrate binding site [chemical binding]; other site 455488011146 putative cosubstrate binding site; other site 455488011147 catalytic site [active] 455488011148 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 455488011149 substrate binding site [chemical binding]; other site 455488011150 16S rRNA methyltransferase B; Provisional; Region: PRK14902 455488011151 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 455488011152 putative RNA binding site [nucleotide binding]; other site 455488011153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488011154 S-adenosylmethionine binding site [chemical binding]; other site 455488011155 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 455488011156 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 455488011157 substrate binding site [chemical binding]; other site 455488011158 hexamer interface [polypeptide binding]; other site 455488011159 metal binding site [ion binding]; metal-binding site 455488011160 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 455488011161 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 455488011162 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 455488011163 ligand binding site [chemical binding]; other site 455488011164 active site 455488011165 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 455488011166 TMAO/DMSO reductase; Reviewed; Region: PRK05363 455488011167 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 455488011168 Moco binding site; other site 455488011169 metal coordination site [ion binding]; other site 455488011170 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 455488011171 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 455488011172 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 455488011173 DctM-like transporters; Region: DctM; pfam06808 455488011174 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 455488011175 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 455488011176 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 455488011177 Methyltransferase domain; Region: Methyltransf_32; pfam13679 455488011178 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 455488011179 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 455488011180 putative active site [active] 455488011181 catalytic site [active] 455488011182 putative metal binding site [ion binding]; other site 455488011183 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488011184 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011185 active site 455488011186 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 455488011187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488011188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 455488011189 Walker A/P-loop; other site 455488011190 ATP binding site [chemical binding]; other site 455488011191 Q-loop/lid; other site 455488011192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488011193 ABC transporter signature motif; other site 455488011194 Walker B; other site 455488011195 D-loop; other site 455488011196 ABC transporter; Region: ABC_tran_2; pfam12848 455488011197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 455488011198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488011200 putative substrate translocation pore; other site 455488011201 Transposase IS200 like; Region: Y1_Tnp; cl00848 455488011202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 455488011203 active site 455488011204 PEGA domain; Region: PEGA; pfam08308 455488011205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488011206 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 455488011207 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 455488011208 Walker A/P-loop; other site 455488011209 ATP binding site [chemical binding]; other site 455488011210 Q-loop/lid; other site 455488011211 ABC transporter signature motif; other site 455488011212 Walker B; other site 455488011213 D-loop; other site 455488011214 H-loop/switch region; other site 455488011215 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 455488011216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488011217 dimer interface [polypeptide binding]; other site 455488011218 conserved gate region; other site 455488011219 ABC-ATPase subunit interface; other site 455488011220 NMT1-like family; Region: NMT1_2; pfam13379 455488011221 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 455488011222 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 455488011223 NlpC/P60 family; Region: NLPC_P60; cl17555 455488011224 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 455488011225 active site 455488011226 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 455488011227 PhoU domain; Region: PhoU; pfam01895 455488011228 PhoU domain; Region: PhoU; pfam01895 455488011229 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 455488011230 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 455488011231 Walker A/P-loop; other site 455488011232 ATP binding site [chemical binding]; other site 455488011233 Q-loop/lid; other site 455488011234 ABC transporter signature motif; other site 455488011235 Walker B; other site 455488011236 D-loop; other site 455488011237 H-loop/switch region; other site 455488011238 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 455488011239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488011240 dimer interface [polypeptide binding]; other site 455488011241 conserved gate region; other site 455488011242 putative PBP binding loops; other site 455488011243 ABC-ATPase subunit interface; other site 455488011244 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 455488011245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488011246 dimer interface [polypeptide binding]; other site 455488011247 conserved gate region; other site 455488011248 putative PBP binding loops; other site 455488011249 ABC-ATPase subunit interface; other site 455488011250 PBP superfamily domain; Region: PBP_like_2; cl17296 455488011251 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 455488011252 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 455488011253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011254 dimer interface [polypeptide binding]; other site 455488011255 phosphorylation site [posttranslational modification] 455488011256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011257 ATP binding site [chemical binding]; other site 455488011258 Mg2+ binding site [ion binding]; other site 455488011259 G-X-G motif; other site 455488011260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 455488011261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011262 active site 455488011263 phosphorylation site [posttranslational modification] 455488011264 intermolecular recognition site; other site 455488011265 dimerization interface [polypeptide binding]; other site 455488011266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 455488011267 DNA binding site [nucleotide binding] 455488011268 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488011269 ligand binding site [chemical binding]; other site 455488011270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 455488011271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 455488011272 metal binding site [ion binding]; metal-binding site 455488011273 active site 455488011274 I-site; other site 455488011275 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 455488011276 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 455488011277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 455488011278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488011279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011280 putative substrate translocation pore; other site 455488011281 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488011282 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011283 active site 455488011284 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 455488011285 CoenzymeA binding site [chemical binding]; other site 455488011286 subunit interaction site [polypeptide binding]; other site 455488011287 PHB binding site; other site 455488011288 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 455488011289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011290 POT family; Region: PTR2; cl17359 455488011291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488011292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011293 putative substrate translocation pore; other site 455488011294 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 455488011295 active site residue [active] 455488011296 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 455488011297 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 455488011298 aromatic arch; other site 455488011299 DCoH dimer interaction site [polypeptide binding]; other site 455488011300 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 455488011301 DCoH tetramer interaction site [polypeptide binding]; other site 455488011302 substrate binding site [chemical binding]; other site 455488011303 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 455488011304 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 455488011305 putative active site [active] 455488011306 putative metal binding site [ion binding]; other site 455488011307 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488011308 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 455488011309 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 455488011310 NAD-dependent deacetylase; Provisional; Region: PRK00481 455488011311 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 455488011312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 455488011313 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 455488011314 intersubunit interface [polypeptide binding]; other site 455488011315 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 455488011316 Transposase domain (DUF772); Region: DUF772; pfam05598 455488011317 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 455488011318 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 455488011319 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 455488011320 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 455488011321 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 455488011322 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 455488011323 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 455488011324 active site 455488011325 catalytic site [active] 455488011326 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 455488011327 active site 455488011328 catalytic site [active] 455488011329 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 455488011330 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 455488011331 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 455488011332 catalytic residues [active] 455488011333 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488011334 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488011335 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011336 active site 455488011337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 455488011338 pyruvate phosphate dikinase; Provisional; Region: PRK09279 455488011339 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 455488011340 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 455488011341 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 455488011342 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 455488011343 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 455488011344 Ligand Binding Site [chemical binding]; other site 455488011345 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 455488011346 CPxP motif; other site 455488011347 Thioredoxin; Region: Thioredoxin_4; pfam13462 455488011348 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488011349 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488011350 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488011351 Thioredoxin; Region: Thioredoxin_4; pfam13462 455488011352 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 455488011353 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 455488011354 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 455488011355 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 455488011356 tetramerization interface [polypeptide binding]; other site 455488011357 active site 455488011358 anthranilate synthase component I; Provisional; Region: PRK13565 455488011359 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 455488011360 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 455488011361 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 455488011362 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 455488011363 glutamine binding [chemical binding]; other site 455488011364 catalytic triad [active] 455488011365 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 455488011366 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 455488011367 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 455488011368 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 455488011369 active site 455488011370 ribulose/triose binding site [chemical binding]; other site 455488011371 phosphate binding site [ion binding]; other site 455488011372 substrate (anthranilate) binding pocket [chemical binding]; other site 455488011373 product (indole) binding pocket [chemical binding]; other site 455488011374 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 455488011375 active site 455488011376 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 455488011377 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 455488011378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488011379 catalytic residue [active] 455488011380 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 455488011381 substrate binding site [chemical binding]; other site 455488011382 active site 455488011383 catalytic residues [active] 455488011384 heterodimer interface [polypeptide binding]; other site 455488011385 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 455488011386 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 455488011387 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 455488011388 PGAP1-like protein; Region: PGAP1; pfam07819 455488011389 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 455488011390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 455488011391 MarR family; Region: MarR_2; cl17246 455488011392 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 455488011393 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 455488011394 active site 455488011395 intersubunit interactions; other site 455488011396 catalytic residue [active] 455488011397 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 455488011398 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 455488011399 putative active site [active] 455488011400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 455488011401 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 455488011402 intersubunit interface [polypeptide binding]; other site 455488011403 active site 455488011404 Zn2+ binding site [ion binding]; other site 455488011405 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 455488011406 catalytic center binding site [active] 455488011407 ATP binding site [chemical binding]; other site 455488011408 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 455488011409 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 455488011410 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 455488011411 dihydrodipicolinate reductase; Provisional; Region: PRK00048 455488011412 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 455488011413 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 455488011414 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 455488011415 dihydrodipicolinate synthase; Region: dapA; TIGR00674 455488011416 dimer interface [polypeptide binding]; other site 455488011417 active site 455488011418 catalytic residue [active] 455488011419 diaminopimelate decarboxylase; Region: lysA; TIGR01048 455488011420 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 455488011421 active site 455488011422 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 455488011423 substrate binding site [chemical binding]; other site 455488011424 catalytic residues [active] 455488011425 dimer interface [polypeptide binding]; other site 455488011426 argininosuccinate lyase; Provisional; Region: PRK00855 455488011427 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 455488011428 active sites [active] 455488011429 tetramer interface [polypeptide binding]; other site 455488011430 OsmC-like protein; Region: OsmC; pfam02566 455488011431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 455488011432 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 455488011433 dimer interface [polypeptide binding]; other site 455488011434 substrate binding site [chemical binding]; other site 455488011435 metal binding site [ion binding]; metal-binding site 455488011436 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 455488011437 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 455488011438 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 455488011439 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 455488011440 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 455488011441 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488011442 active site 455488011443 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488011444 active site 455488011445 DNA methylase; Region: N6_N4_Mtase; cl17433 455488011446 Protein of unknown function (DUF938); Region: DUF938; pfam06080 455488011447 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488011448 HSP70 interaction site [polypeptide binding]; other site 455488011449 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 455488011450 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 455488011451 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 455488011452 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 455488011453 NAD(P) binding site [chemical binding]; other site 455488011454 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 455488011455 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488011456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488011457 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 455488011458 active site 455488011459 OPT oligopeptide transporter protein; Region: OPT; cl14607 455488011460 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 455488011461 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 455488011462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488011463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488011464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 455488011465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 455488011466 active site 455488011467 ATP binding site [chemical binding]; other site 455488011468 substrate binding site [chemical binding]; other site 455488011469 activation loop (A-loop); other site 455488011470 multifunctional aminopeptidase A; Provisional; Region: PRK00913 455488011471 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 455488011472 interface (dimer of trimers) [polypeptide binding]; other site 455488011473 Substrate-binding/catalytic site; other site 455488011474 Zn-binding sites [ion binding]; other site 455488011475 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 455488011476 dimer interface [polypeptide binding]; other site 455488011477 substrate binding site [chemical binding]; other site 455488011478 metal binding sites [ion binding]; metal-binding site 455488011479 Hemerythrin; Region: Hemerythrin; cd12107 455488011480 Fe binding site [ion binding]; other site 455488011481 Arginase family; Region: Arginase; pfam00491 455488011482 active site 455488011483 metal binding site [ion binding]; metal-binding site 455488011484 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 455488011485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 455488011486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488011487 homodimer interface [polypeptide binding]; other site 455488011488 catalytic residue [active] 455488011489 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 455488011490 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 455488011491 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488011492 Outer membrane efflux protein; Region: OEP; pfam02321 455488011493 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 455488011494 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 455488011495 MarR family; Region: MarR; pfam01047 455488011496 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 455488011497 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 455488011498 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011499 active site 455488011500 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 455488011501 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 455488011502 putative active site [active] 455488011503 putative CoA binding site [chemical binding]; other site 455488011504 nudix motif; other site 455488011505 metal binding site [ion binding]; metal-binding site 455488011506 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488011507 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 455488011508 active site 455488011509 active site 455488011510 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 455488011511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011512 active site 455488011513 phosphorylation site [posttranslational modification] 455488011514 intermolecular recognition site; other site 455488011515 dimerization interface [polypeptide binding]; other site 455488011516 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 455488011517 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 455488011518 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 455488011519 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 455488011520 active site 455488011521 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 455488011522 lipoyl attachment site [posttranslational modification]; other site 455488011523 Response regulator receiver domain; Region: Response_reg; pfam00072 455488011524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011525 active site 455488011526 phosphorylation site [posttranslational modification] 455488011527 intermolecular recognition site; other site 455488011528 dimerization interface [polypeptide binding]; other site 455488011529 PAS fold; Region: PAS; pfam00989 455488011530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 455488011531 putative active site [active] 455488011532 heme pocket [chemical binding]; other site 455488011533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488011534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011535 dimer interface [polypeptide binding]; other site 455488011536 phosphorylation site [posttranslational modification] 455488011537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011538 ATP binding site [chemical binding]; other site 455488011539 Mg2+ binding site [ion binding]; other site 455488011540 G-X-G motif; other site 455488011541 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 455488011542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011543 dimerization interface [polypeptide binding]; other site 455488011544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011545 dimerization interface [polypeptide binding]; other site 455488011546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011547 dimerization interface [polypeptide binding]; other site 455488011548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011549 dimerization interface [polypeptide binding]; other site 455488011550 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 455488011551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011552 dimerization interface [polypeptide binding]; other site 455488011553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011554 dimerization interface [polypeptide binding]; other site 455488011555 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 455488011556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011557 dimerization interface [polypeptide binding]; other site 455488011558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011559 dimerization interface [polypeptide binding]; other site 455488011560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011561 dimerization interface [polypeptide binding]; other site 455488011562 HAMP domain; Region: HAMP; pfam00672 455488011563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011564 dimerization interface [polypeptide binding]; other site 455488011565 GAF domain; Region: GAF_2; pfam13185 455488011566 GAF domain; Region: GAF_3; pfam13492 455488011567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488011568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011569 dimer interface [polypeptide binding]; other site 455488011570 phosphorylation site [posttranslational modification] 455488011571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011572 ATP binding site [chemical binding]; other site 455488011573 Mg2+ binding site [ion binding]; other site 455488011574 G-X-G motif; other site 455488011575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488011576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011577 active site 455488011578 phosphorylation site [posttranslational modification] 455488011579 intermolecular recognition site; other site 455488011580 dimerization interface [polypeptide binding]; other site 455488011581 trehalose synthase; Region: treS_nterm; TIGR02456 455488011582 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 455488011583 Ca binding site [ion binding]; other site 455488011584 active site 455488011585 catalytic site [active] 455488011586 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 455488011587 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488011588 active site 455488011589 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 455488011590 carbohydrate binding site [chemical binding]; other site 455488011591 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 455488011592 trimer interface; other site 455488011593 sugar binding site [chemical binding]; other site 455488011594 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 455488011595 putative ligand binding site [chemical binding]; other site 455488011596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 455488011597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488011598 dimer interface [polypeptide binding]; other site 455488011599 conserved gate region; other site 455488011600 putative PBP binding loops; other site 455488011601 ABC-ATPase subunit interface; other site 455488011602 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 455488011603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 455488011604 dimer interface [polypeptide binding]; other site 455488011605 conserved gate region; other site 455488011606 putative PBP binding loops; other site 455488011607 ABC-ATPase subunit interface; other site 455488011608 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 455488011609 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 455488011610 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 455488011611 Walker A/P-loop; other site 455488011612 ATP binding site [chemical binding]; other site 455488011613 Q-loop/lid; other site 455488011614 ABC transporter signature motif; other site 455488011615 Walker B; other site 455488011616 D-loop; other site 455488011617 H-loop/switch region; other site 455488011618 TOBE domain; Region: TOBE_2; pfam08402 455488011619 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 455488011620 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 455488011621 active site 455488011622 catalytic site [active] 455488011623 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 455488011624 Uncharacterized conserved protein [Function unknown]; Region: COG3461 455488011625 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 455488011626 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 455488011627 Response regulator receiver domain; Region: Response_reg; pfam00072 455488011628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011629 active site 455488011630 phosphorylation site [posttranslational modification] 455488011631 intermolecular recognition site; other site 455488011632 dimerization interface [polypeptide binding]; other site 455488011633 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 455488011634 Predicted exporter [General function prediction only]; Region: COG4258 455488011635 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 455488011636 active site 455488011637 metal binding site [ion binding]; metal-binding site 455488011638 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 455488011639 putative acyl-acceptor binding pocket; other site 455488011640 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 455488011641 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 455488011642 putative acyl-acceptor binding pocket; other site 455488011643 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 455488011644 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 455488011645 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 455488011646 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 455488011647 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 455488011648 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 455488011649 DoxX; Region: DoxX; pfam07681 455488011650 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 455488011651 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 455488011652 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 455488011653 HlyD family secretion protein; Region: HlyD_3; pfam13437 455488011654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 455488011655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 455488011656 Walker A/P-loop; other site 455488011657 ATP binding site [chemical binding]; other site 455488011658 Q-loop/lid; other site 455488011659 ABC transporter signature motif; other site 455488011660 Walker B; other site 455488011661 D-loop; other site 455488011662 H-loop/switch region; other site 455488011663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488011664 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488011665 FtsX-like permease family; Region: FtsX; pfam02687 455488011666 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 455488011667 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 455488011668 FtsX-like permease family; Region: FtsX; pfam02687 455488011669 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 455488011670 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 455488011671 Catalytic site [active] 455488011672 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 455488011673 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 455488011674 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 455488011675 active site 455488011676 DNA binding site [nucleotide binding] 455488011677 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 455488011678 DNA binding site [nucleotide binding] 455488011679 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 455488011680 nickel binding site [ion binding]; other site 455488011681 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 455488011682 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 455488011683 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 455488011684 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 455488011685 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 455488011686 4Fe-4S binding domain; Region: Fer4_6; pfam12837 455488011687 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 455488011688 CPxP motif; other site 455488011689 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 455488011690 active site 455488011691 phosphorylation site [posttranslational modification] 455488011692 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 455488011693 30S subunit binding site; other site 455488011694 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 455488011695 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 455488011696 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 455488011697 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 455488011698 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 455488011699 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 455488011700 Walker A/P-loop; other site 455488011701 ATP binding site [chemical binding]; other site 455488011702 Q-loop/lid; other site 455488011703 ABC transporter signature motif; other site 455488011704 Walker B; other site 455488011705 D-loop; other site 455488011706 H-loop/switch region; other site 455488011707 OstA-like protein; Region: OstA; cl00844 455488011708 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 455488011709 putative acyl-acceptor binding pocket; other site 455488011710 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 455488011711 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 455488011712 CTP synthetase; Validated; Region: pyrG; PRK05380 455488011713 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 455488011714 Catalytic site [active] 455488011715 active site 455488011716 UTP binding site [chemical binding]; other site 455488011717 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 455488011718 active site 455488011719 putative oxyanion hole; other site 455488011720 catalytic triad [active] 455488011721 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 455488011722 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 455488011723 Ligand binding site; other site 455488011724 oligomer interface; other site 455488011725 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 455488011726 active site 455488011727 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 455488011728 homodimer interface [polypeptide binding]; other site 455488011729 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 455488011730 S4 RNA-binding domain; Region: S4; smart00363 455488011731 RNA binding surface [nucleotide binding]; other site 455488011732 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 455488011733 active site 455488011734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 455488011735 GTPase CgtA; Reviewed; Region: obgE; PRK12299 455488011736 GTP1/OBG; Region: GTP1_OBG; pfam01018 455488011737 Obg GTPase; Region: Obg; cd01898 455488011738 G1 box; other site 455488011739 GTP/Mg2+ binding site [chemical binding]; other site 455488011740 Switch I region; other site 455488011741 G2 box; other site 455488011742 G3 box; other site 455488011743 Switch II region; other site 455488011744 G4 box; other site 455488011745 G5 box; other site 455488011746 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 455488011747 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 455488011748 Uncharacterized conserved protein [Function unknown]; Region: COG3339 455488011749 Inward rectifier potassium channel; Region: IRK; pfam01007 455488011750 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 455488011751 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 455488011752 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 455488011753 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 455488011754 GatB domain; Region: GatB_Yqey; smart00845 455488011755 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 455488011756 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 455488011757 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 455488011758 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 455488011759 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 455488011760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488011761 TPR motif; other site 455488011762 TPR repeat; Region: TPR_11; pfam13414 455488011763 binding surface 455488011764 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 455488011765 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 455488011766 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 455488011767 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 455488011768 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 455488011769 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 455488011770 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 455488011771 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 455488011772 ligand binding site [chemical binding]; other site 455488011773 membrane protein; Provisional; Region: PRK14400 455488011774 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 455488011775 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 455488011776 Yip1 domain; Region: Yip1; pfam04893 455488011777 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 455488011778 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 455488011779 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 455488011780 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 455488011781 SLBB domain; Region: SLBB; pfam10531 455488011782 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 455488011783 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 455488011784 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 455488011785 putative dimer interface [polypeptide binding]; other site 455488011786 [2Fe-2S] cluster binding site [ion binding]; other site 455488011787 PilZ domain; Region: PilZ; cl01260 455488011788 Response regulator receiver domain; Region: Response_reg; pfam00072 455488011789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011790 active site 455488011791 phosphorylation site [posttranslational modification] 455488011792 intermolecular recognition site; other site 455488011793 dimerization interface [polypeptide binding]; other site 455488011794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 455488011795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 455488011796 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 455488011797 IHF - DNA interface [nucleotide binding]; other site 455488011798 IHF dimer interface [polypeptide binding]; other site 455488011799 PilZ domain; Region: PilZ; pfam07238 455488011800 amidophosphoribosyltransferase; Provisional; Region: PRK09123 455488011801 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 455488011802 active site 455488011803 tetramer interface [polypeptide binding]; other site 455488011804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 455488011805 active site 455488011806 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 455488011807 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 455488011808 active site 455488011809 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 455488011810 PilZ domain; Region: PilZ; cl01260 455488011811 PilZ domain; Region: PilZ; cl01260 455488011812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011813 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488011814 active site 455488011815 phosphorylation site [posttranslational modification] 455488011816 intermolecular recognition site; other site 455488011817 dimerization interface [polypeptide binding]; other site 455488011818 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 455488011819 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 455488011820 dimerization interface [polypeptide binding]; other site 455488011821 ATP binding site [chemical binding]; other site 455488011822 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 455488011823 dimerization interface [polypeptide binding]; other site 455488011824 ATP binding site [chemical binding]; other site 455488011825 RNase_H superfamily; Region: RNase_H_2; pfam13482 455488011826 Part of AAA domain; Region: AAA_19; pfam13245 455488011827 AAA domain; Region: AAA_12; pfam13087 455488011828 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 455488011829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011830 dimer interface [polypeptide binding]; other site 455488011831 phosphorylation site [posttranslational modification] 455488011832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011833 ATP binding site [chemical binding]; other site 455488011834 Mg2+ binding site [ion binding]; other site 455488011835 G-X-G motif; other site 455488011836 Response regulator receiver domain; Region: Response_reg; pfam00072 455488011837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011838 active site 455488011839 phosphorylation site [posttranslational modification] 455488011840 intermolecular recognition site; other site 455488011841 dimerization interface [polypeptide binding]; other site 455488011842 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 455488011843 active site 455488011844 Smr domain; Region: Smr; pfam01713 455488011845 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 455488011846 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 455488011847 30S subunit binding site; other site 455488011848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011849 active site 455488011850 phosphorylation site [posttranslational modification] 455488011851 intermolecular recognition site; other site 455488011852 dimerization interface [polypeptide binding]; other site 455488011853 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 455488011854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011855 dimer interface [polypeptide binding]; other site 455488011856 phosphorylation site [posttranslational modification] 455488011857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011858 ATP binding site [chemical binding]; other site 455488011859 G-X-G motif; other site 455488011860 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 455488011861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011862 active site 455488011863 phosphorylation site [posttranslational modification] 455488011864 intermolecular recognition site; other site 455488011865 dimerization interface [polypeptide binding]; other site 455488011866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488011867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011868 ATP binding site [chemical binding]; other site 455488011869 Mg2+ binding site [ion binding]; other site 455488011870 G-X-G motif; other site 455488011871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011872 dimerization interface [polypeptide binding]; other site 455488011873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011874 phosphorylation site [posttranslational modification] 455488011875 dimer interface [polypeptide binding]; other site 455488011876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011877 ATP binding site [chemical binding]; other site 455488011878 Mg2+ binding site [ion binding]; other site 455488011879 G-X-G motif; other site 455488011880 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 455488011881 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 455488011882 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 455488011883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 455488011884 FeS/SAM binding site; other site 455488011885 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 455488011886 active site 455488011887 DNA binding site [nucleotide binding] 455488011888 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 455488011889 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 455488011890 domain interfaces; other site 455488011891 active site 455488011892 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 455488011893 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 455488011894 active site 455488011895 NUDIX domain; Region: NUDIX; pfam00293 455488011896 nudix motif; other site 455488011897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 455488011898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 455488011899 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488011900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011901 active site 455488011902 phosphorylation site [posttranslational modification] 455488011903 intermolecular recognition site; other site 455488011904 dimerization interface [polypeptide binding]; other site 455488011905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488011906 Walker A motif; other site 455488011907 ATP binding site [chemical binding]; other site 455488011908 Walker B motif; other site 455488011909 arginine finger; other site 455488011910 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488011911 FtsH Extracellular; Region: FtsH_ext; pfam06480 455488011912 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 455488011913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488011914 Walker A motif; other site 455488011915 ATP binding site [chemical binding]; other site 455488011916 Walker B motif; other site 455488011917 arginine finger; other site 455488011918 Peptidase family M41; Region: Peptidase_M41; pfam01434 455488011919 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 455488011920 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 455488011921 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 455488011922 putative active site [active] 455488011923 catalytic site [active] 455488011924 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 455488011925 putative active site [active] 455488011926 catalytic site [active] 455488011927 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 455488011928 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 455488011929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 455488011930 dimerization interface [polypeptide binding]; other site 455488011931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011932 dimer interface [polypeptide binding]; other site 455488011933 phosphorylation site [posttranslational modification] 455488011934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011935 ATP binding site [chemical binding]; other site 455488011936 Mg2+ binding site [ion binding]; other site 455488011937 G-X-G motif; other site 455488011938 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 455488011939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 455488011940 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 455488011941 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 455488011942 Nitrogen regulatory protein P-II; Region: P-II; smart00938 455488011943 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 455488011944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488011945 dimer interface [polypeptide binding]; other site 455488011946 phosphorylation site [posttranslational modification] 455488011947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488011948 ATP binding site [chemical binding]; other site 455488011949 Mg2+ binding site [ion binding]; other site 455488011950 G-X-G motif; other site 455488011951 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 455488011952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011953 active site 455488011954 phosphorylation site [posttranslational modification] 455488011955 intermolecular recognition site; other site 455488011956 dimerization interface [polypeptide binding]; other site 455488011957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488011958 Walker A motif; other site 455488011959 ATP binding site [chemical binding]; other site 455488011960 Walker B motif; other site 455488011961 arginine finger; other site 455488011962 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 455488011963 glutamine synthetase, type I; Region: GlnA; TIGR00653 455488011964 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 455488011965 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 455488011966 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 455488011967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 455488011968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 455488011969 putative substrate translocation pore; other site 455488011970 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 455488011971 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 455488011972 Walker A/P-loop; other site 455488011973 ATP binding site [chemical binding]; other site 455488011974 Q-loop/lid; other site 455488011975 ABC transporter signature motif; other site 455488011976 Walker B; other site 455488011977 D-loop; other site 455488011978 H-loop/switch region; other site 455488011979 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 455488011980 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 455488011981 Walker A/P-loop; other site 455488011982 ATP binding site [chemical binding]; other site 455488011983 Q-loop/lid; other site 455488011984 ABC transporter signature motif; other site 455488011985 Walker B; other site 455488011986 D-loop; other site 455488011987 H-loop/switch region; other site 455488011988 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 455488011989 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 455488011990 TM-ABC transporter signature motif; other site 455488011991 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 455488011992 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 455488011993 TM-ABC transporter signature motif; other site 455488011994 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 455488011995 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 455488011996 putative ligand binding site [chemical binding]; other site 455488011997 Response regulator receiver domain; Region: Response_reg; pfam00072 455488011998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488011999 active site 455488012000 phosphorylation site [posttranslational modification] 455488012001 intermolecular recognition site; other site 455488012002 dimerization interface [polypeptide binding]; other site 455488012003 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 455488012004 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 455488012005 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 455488012006 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 455488012007 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 455488012008 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 455488012009 Protein of unknown function DUF58; Region: DUF58; pfam01882 455488012010 MoxR-like ATPases [General function prediction only]; Region: COG0714 455488012011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 455488012012 Walker A motif; other site 455488012013 ATP binding site [chemical binding]; other site 455488012014 Walker B motif; other site 455488012015 arginine finger; other site 455488012016 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 455488012017 Zn binding site [ion binding]; other site 455488012018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488012019 TPR motif; other site 455488012020 binding surface 455488012021 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 455488012022 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 455488012023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 455488012024 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 455488012025 DNA binding residues [nucleotide binding] 455488012026 tyrosine kinase; Provisional; Region: PRK11519 455488012027 Chain length determinant protein; Region: Wzz; pfam02706 455488012028 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 455488012029 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488012030 polysaccharide export protein Wza; Provisional; Region: PRK15078 455488012031 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 455488012032 Low molecular weight phosphatase family; Region: LMWPc; cd00115 455488012033 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 455488012034 active site 455488012035 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 455488012036 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 455488012037 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 455488012038 NAD(P) binding site [chemical binding]; other site 455488012039 homodimer interface [polypeptide binding]; other site 455488012040 substrate binding site [chemical binding]; other site 455488012041 active site 455488012042 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 455488012043 putative trimer interface [polypeptide binding]; other site 455488012044 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 455488012045 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 455488012046 Mg++ binding site [ion binding]; other site 455488012047 putative catalytic motif [active] 455488012048 putative substrate binding site [chemical binding]; other site 455488012049 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488012050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488012051 NAD(P) binding site [chemical binding]; other site 455488012052 active site 455488012053 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 455488012054 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 455488012055 putative NAD(P) binding site [chemical binding]; other site 455488012056 active site 455488012057 putative substrate binding site [chemical binding]; other site 455488012058 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 455488012059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488012060 putative ADP-binding pocket [chemical binding]; other site 455488012061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488012062 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 455488012063 putative ADP-binding pocket [chemical binding]; other site 455488012064 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 455488012065 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 455488012066 putative ADP-binding pocket [chemical binding]; other site 455488012067 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 455488012068 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 455488012069 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 455488012070 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 455488012071 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 455488012072 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 455488012073 NAD binding site [chemical binding]; other site 455488012074 substrate binding site [chemical binding]; other site 455488012075 homodimer interface [polypeptide binding]; other site 455488012076 active site 455488012077 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 455488012078 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 455488012079 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 455488012080 substrate binding site; other site 455488012081 tetramer interface; other site 455488012082 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 455488012083 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 455488012084 NADP binding site [chemical binding]; other site 455488012085 active site 455488012086 putative substrate binding site [chemical binding]; other site 455488012087 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 455488012088 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 455488012089 NADP binding site [chemical binding]; other site 455488012090 active site 455488012091 putative substrate binding site [chemical binding]; other site 455488012092 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 455488012093 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 455488012094 NADP-binding site; other site 455488012095 homotetramer interface [polypeptide binding]; other site 455488012096 substrate binding site [chemical binding]; other site 455488012097 homodimer interface [polypeptide binding]; other site 455488012098 active site 455488012099 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 455488012100 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 455488012101 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 455488012102 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 455488012103 Domain of unknown function (DUF222); Region: DUF222; pfam02720 455488012104 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 455488012105 active site 455488012106 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 455488012107 Ligand binding site; other site 455488012108 Putative Catalytic site; other site 455488012109 DXD motif; other site 455488012110 Methyltransferase domain; Region: Methyltransf_23; pfam13489 455488012111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488012112 S-adenosylmethionine binding site [chemical binding]; other site 455488012113 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 455488012114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 455488012115 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 455488012116 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 455488012117 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 455488012118 active site 455488012119 homodimer interface [polypeptide binding]; other site 455488012120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 455488012121 TIGR01777 family protein; Region: yfcH 455488012122 NAD(P) binding site [chemical binding]; other site 455488012123 active site 455488012124 peptide chain release factor 1; Provisional; Region: PRK04011 455488012125 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 455488012126 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 455488012127 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 455488012128 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 455488012129 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 455488012130 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 455488012131 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 455488012132 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 455488012133 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 455488012134 PAS domain; Region: PAS_9; pfam13426 455488012135 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 455488012136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488012137 dimer interface [polypeptide binding]; other site 455488012138 phosphorylation site [posttranslational modification] 455488012139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488012140 ATP binding site [chemical binding]; other site 455488012141 Mg2+ binding site [ion binding]; other site 455488012142 G-X-G motif; other site 455488012143 Protein of unknown function DUF111; Region: DUF111; pfam01969 455488012144 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 455488012145 AIR carboxylase; Region: AIRC; smart01001 455488012146 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 455488012147 Chemotaxis phosphatase CheX; Region: CheX; cl15816 455488012148 CheC-like family; Region: CheC; pfam04509 455488012149 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 455488012150 putative binding surface; other site 455488012151 active site 455488012152 P2 response regulator binding domain; Region: P2; pfam07194 455488012153 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 455488012154 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 455488012155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488012156 ATP binding site [chemical binding]; other site 455488012157 Mg2+ binding site [ion binding]; other site 455488012158 G-X-G motif; other site 455488012159 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 455488012160 Response regulator receiver domain; Region: Response_reg; pfam00072 455488012161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 455488012162 active site 455488012163 phosphorylation site [posttranslational modification] 455488012164 intermolecular recognition site; other site 455488012165 dimerization interface [polypeptide binding]; other site 455488012166 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 455488012167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 455488012168 dimerization interface [polypeptide binding]; other site 455488012169 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 455488012170 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 455488012171 dimer interface [polypeptide binding]; other site 455488012172 putative CheW interface [polypeptide binding]; other site 455488012173 thiamine monophosphate kinase; Provisional; Region: PRK05731 455488012174 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 455488012175 ATP binding site [chemical binding]; other site 455488012176 dimerization interface [polypeptide binding]; other site 455488012177 Sensory domain found in PocR; Region: PocR; pfam10114 455488012178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 455488012179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 455488012180 dimer interface [polypeptide binding]; other site 455488012181 phosphorylation site [posttranslational modification] 455488012182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 455488012183 ATP binding site [chemical binding]; other site 455488012184 Mg2+ binding site [ion binding]; other site 455488012185 G-X-G motif; other site 455488012186 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 455488012187 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 455488012188 G1 box; other site 455488012189 GTP/Mg2+ binding site [chemical binding]; other site 455488012190 G2 box; other site 455488012191 Switch I region; other site 455488012192 G3 box; other site 455488012193 Switch II region; other site 455488012194 G4 box; other site 455488012195 G5 box; other site 455488012196 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 455488012197 DEAD/DEAH box helicase; Region: DEAD; pfam00270 455488012198 DEAD_2; Region: DEAD_2; pfam06733 455488012199 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 455488012200 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 455488012201 Peptidase family M50; Region: Peptidase_M50; pfam02163 455488012202 active site 455488012203 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 455488012204 putative substrate binding region [chemical binding]; other site 455488012205 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 455488012206 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 455488012207 putative ligand binding site [chemical binding]; other site 455488012208 chaperone protein DnaJ; Provisional; Region: PRK10767 455488012209 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 455488012210 HSP70 interaction site [polypeptide binding]; other site 455488012211 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 455488012212 Zn binding sites [ion binding]; other site 455488012213 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 455488012214 dimer interface [polypeptide binding]; other site 455488012215 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 455488012216 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 455488012217 nucleotide binding site [chemical binding]; other site 455488012218 NEF interaction site [polypeptide binding]; other site 455488012219 SBD interface [polypeptide binding]; other site 455488012220 GrpE; Region: GrpE; pfam01025 455488012221 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 455488012222 dimer interface [polypeptide binding]; other site 455488012223 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 455488012224 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 455488012225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 455488012226 binding surface 455488012227 TPR motif; other site 455488012228 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 455488012229 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 455488012230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 455488012231 ATP binding site [chemical binding]; other site 455488012232 putative Mg++ binding site [ion binding]; other site 455488012233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 455488012234 nucleotide binding region [chemical binding]; other site 455488012235 ATP-binding site [chemical binding]; other site 455488012236 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 455488012237 SurA N-terminal domain; Region: SurA_N_3; cl07813 455488012238 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 455488012239 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 455488012240 SurA N-terminal domain; Region: SurA_N; pfam09312 455488012241 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 455488012242 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 455488012243 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 455488012244 GTP-binding protein YchF; Reviewed; Region: PRK09601 455488012245 YchF GTPase; Region: YchF; cd01900 455488012246 G1 box; other site 455488012247 GTP/Mg2+ binding site [chemical binding]; other site 455488012248 Switch I region; other site 455488012249 G2 box; other site 455488012250 Switch II region; other site 455488012251 G3 box; other site 455488012252 G4 box; other site 455488012253 G5 box; other site 455488012254 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 455488012255 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 455488012256 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 455488012257 ATP synthase subunit C; Region: ATP-synt_C; cl00466 455488012258 F0F1 ATP synthase subunit A; Provisional; Region: PRK13419 455488012259 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 455488012260 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 455488012261 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 455488012262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 455488012263 catalytic residue [active] 455488012264 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 455488012265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 455488012266 inhibitor-cofactor binding pocket; inhibition site 455488012267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 455488012268 catalytic residue [active] 455488012269 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 455488012270 DNA gyrase subunit A; Validated; Region: PRK05560 455488012271 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 455488012272 CAP-like domain; other site 455488012273 active site 455488012274 primary dimer interface [polypeptide binding]; other site 455488012275 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 455488012276 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 455488012277 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 455488012278 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 455488012279 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 455488012280 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 455488012281 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 455488012282 gamma subunit interface [polypeptide binding]; other site 455488012283 epsilon subunit interface [polypeptide binding]; other site 455488012284 LBP interface [polypeptide binding]; other site 455488012285 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 455488012286 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 455488012287 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 455488012288 alpha subunit interaction interface [polypeptide binding]; other site 455488012289 Walker A motif; other site 455488012290 ATP binding site [chemical binding]; other site 455488012291 Walker B motif; other site 455488012292 inhibitor binding site; inhibition site 455488012293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 455488012294 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 455488012295 core domain interface [polypeptide binding]; other site 455488012296 delta subunit interface [polypeptide binding]; other site 455488012297 epsilon subunit interface [polypeptide binding]; other site 455488012298 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 455488012299 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 455488012300 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 455488012301 beta subunit interaction interface [polypeptide binding]; other site 455488012302 Walker A motif; other site 455488012303 ATP binding site [chemical binding]; other site 455488012304 Walker B motif; other site 455488012305 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 455488012306 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 455488012307 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 455488012308 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 455488012309 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 455488012310 putative dimer interface [polypeptide binding]; other site 455488012311 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 455488012312 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 455488012313 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 455488012314 ParB-like nuclease domain; Region: ParB; smart00470 455488012315 KorB domain; Region: KorB; pfam08535 455488012316 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 455488012317 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 455488012318 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 455488012319 Magnesium ion binding site [ion binding]; other site 455488012320 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 455488012321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 455488012322 S-adenosylmethionine binding site [chemical binding]; other site 455488012323 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 455488012324 G-X-X-G motif; other site 455488012325 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 455488012326 RxxxH motif; other site 455488012327 membrane protein insertase; Provisional; Region: PRK01318 455488012328 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 455488012329 Haemolytic domain; Region: Haemolytic; pfam01809 455488012330 Ribonuclease P; Region: Ribonuclease_P; pfam00825 455488012331 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399